E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.026 0.076 -9999.0 0.0 -0.393 12.0 12.0 KLHL20 -0.009 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.003 0.071 -9999.0 0.0 -0.521 7.0 7.0 Rac1/GDP 0.048 0.052 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.025 0.079 -9999.0 0.0 -0.398 13.0 13.0 AP1M1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.006 0.073 -9999.0 0.0 -0.852 3.0 3.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.01 0.042 -9999.0 0.0 -0.852 1.0 1.0 CDC42/GTP -0.007 0.039 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.007 0.026 -9999.0 0.0 -0.226 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.023 0.053 -9999.0 0.0 -0.524 1.0 1.0 RAPGEF1 0.038 0.067 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.013 0.071 -9999.0 0.0 -0.407 13.0 13.0 CRK 0.032 0.072 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin -0.028 0.114 -9999.0 0.0 -0.573 15.0 15.0 alphaE/beta7 Integrin 0.018 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.01 0.042 -9999.0 0.0 -0.852 1.0 1.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.02 0.047 -9999.0 0.0 -0.53 3.0 3.0 DLG1 0.026 0.076 -9999.0 0.0 -0.393 12.0 12.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.006 0.028 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.014 0.068 -9999.0 0.0 -0.53 5.0 5.0 PI3K -0.007 0.036 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.016 0.137 -9999.0 0.0 -0.51 27.0 27.0 TIAM1 -0.003 0.101 -9999.0 0.0 -0.62 10.0 10.0 E-cadherin(dimer)/Ca2+ 0.02 0.049 -9999.0 0.0 -0.498 1.0 1.0 AKT1 -0.004 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.001 0.08 -9999.0 0.0 -0.466 12.0 12.0 RhoA/GDP 0.047 0.052 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.034 0.037 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GDP 0.047 0.052 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.006 0.07 -9999.0 0.0 -0.287 15.0 15.0 ITGB7 0.011 0.023 -9999.0 0.0 -0.466 1.0 1.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.023 0.052 -9999.0 0.0 -0.523 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.014 0.049 -9999.0 0.0 -0.504 1.0 1.0 mol:GDP 0.044 0.059 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 -0.001 0.028 -9999.0 0.0 -0.58 1.0 1.0 JUP -0.019 0.161 -9999.0 0.0 -0.852 15.0 15.0 p120 catenin/RhoA/GDP -0.008 0.041 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 -0.001 0.029 -9999.0 0.0 -0.58 1.0 1.0 PIP5K1C/AP1M1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.026 0.036 -9999.0 0.0 -0.262 4.0 4.0 NME1 0.01 0.042 -9999.0 0.0 -0.852 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.026 0.076 -9999.0 0.0 -0.393 12.0 12.0 regulation of cell-cell adhesion -0.006 0.034 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.004 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.008 0.044 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.024 0.097 -9999.0 0.0 -0.491 15.0 15.0 CCND1 0.03 0.044 -9999.0 0.0 -0.332 4.0 4.0 VAV2 0.033 0.078 -9999.0 0.0 -9999.0 0.0 0.0 RAP1/GDP 0.042 0.056 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.026 0.073 -9999.0 0.0 -0.382 12.0 12.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.016 0.105 -9999.0 0.0 -0.465 16.0 16.0 E-cadherin/beta catenin -0.009 0.055 -9999.0 0.0 -0.322 12.0 12.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.026 0.076 -9999.0 0.0 -0.393 12.0 12.0 PIK3CA 0.01 0.042 -9999.0 0.0 -0.852 1.0 1.0 Rac1/GTP -0.014 0.054 -9999.0 0.0 -0.387 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.009 0.052 -9999.0 0.0 -0.573 1.0 1.0 ITGAE 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.014 0.073 -9999.0 0.0 -0.415 13.0 13.0