Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.056 0.281 -9999.0 0.0 -0.896 30.0 30.0 IHH -0.053 0.187 -9999.0 0.0 -0.547 49.0 49.0 SHH Np/Cholesterol/GAS1 -0.042 0.139 -9999.0 0.0 -0.541 15.0 15.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.042 0.138 0.537 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 -0.031 0.195 -9999.0 0.0 -0.705 17.0 17.0 SMO -0.04 0.208 -9999.0 0.0 -0.706 21.0 21.0 AKT1 0.004 0.088 -9999.0 0.0 -0.365 1.0 1.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.039 0.151 -9999.0 0.0 -0.475 44.0 44.0 ADRBK1 0.01 0.042 -9999.0 0.0 -0.852 1.0 1.0 heart looping -0.039 0.202 -9999.0 0.0 -0.687 21.0 21.0 STIL -0.103 0.254 -9999.0 0.0 -0.689 38.0 38.0 DHH N/PTCH2 -0.078 0.228 -9999.0 0.0 -0.653 53.0 53.0 DHH N/PTCH1 -0.03 0.178 -9999.0 0.0 -0.65 16.0 16.0 PIK3CA 0.01 0.042 -9999.0 0.0 -0.852 1.0 1.0 DHH -0.0 0.077 -9999.0 0.0 -0.466 11.0 11.0 PTHLH -0.075 0.316 -9999.0 0.0 -1.011 32.0 32.0 determination of left/right symmetry -0.039 0.202 -9999.0 0.0 -0.687 21.0 21.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.073 0.31 -9999.0 0.0 -0.991 32.0 32.0 IHH N/Hhip -0.11 0.212 -9999.0 0.0 -0.437 109.0 109.0 DHH N/Hhip -0.075 0.161 -9999.0 0.0 -0.34 108.0 108.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.039 0.202 -9999.0 0.0 -0.687 21.0 21.0 pancreas development -0.106 0.208 -9999.0 0.0 -0.469 102.0 102.0 HHAT 0.006 0.057 -9999.0 0.0 -0.466 6.0 6.0 PI3K 0.017 0.033 -9999.0 0.0 -0.659 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.053 0.174 -9999.0 0.0 -0.494 54.0 54.0 somite specification -0.039 0.202 -9999.0 0.0 -0.687 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.038 0.18 -9999.0 0.0 -0.63 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.077 0.2 -9999.0 0.0 -0.537 59.0 59.0 SHH Np/Cholesterol/Megalin -0.085 0.204 -9999.0 0.0 -0.541 62.0 62.0 SHH -0.016 0.123 -9999.0 0.0 -0.383 38.0 38.0 catabolic process -0.033 0.188 -9999.0 0.0 -0.683 16.0 16.0 SMO/Vitamin D3 -0.04 0.196 -9999.0 0.0 -0.709 16.0 16.0 SHH Np/Cholesterol/Hhip -0.07 0.16 -9999.0 0.0 -0.52 26.0 26.0 LRP2 -0.107 0.294 -9999.0 0.0 -0.852 56.0 56.0 receptor-mediated endocytosis -0.075 0.209 -9999.0 0.0 -0.627 27.0 27.0 SHH Np/Cholesterol/BOC -0.034 0.128 -9999.0 0.0 -0.525 12.0 12.0 SHH Np/Cholesterol/CDO -0.015 0.113 -9999.0 0.0 -0.518 12.0 12.0 mesenchymal cell differentiation 0.07 0.159 0.515 26.0 -9999.0 0.0 26.0 mol:Vitamin D3 -0.036 0.183 -9999.0 0.0 -0.635 18.0 18.0 IHH N/PTCH2 -0.114 0.259 -9999.0 0.0 -0.654 68.0 68.0 CDON -0.003 0.101 -9999.0 0.0 -0.62 10.0 10.0 IHH N/PTCH1 -0.033 0.192 -9999.0 0.0 -0.696 16.0 16.0 Megalin/LRPAP1 -0.075 0.231 -9999.0 0.0 -0.659 56.0 56.0 PTCH2 -0.099 0.288 -9999.0 0.0 -0.831 55.0 55.0 SHH Np/Cholesterol -0.027 0.092 -9999.0 0.0 -0.524 7.0 7.0 PTCH1 -0.033 0.19 -9999.0 0.0 -0.688 16.0 16.0 HHIP -0.106 0.208 -9999.0 0.0 -0.47 102.0 102.0