Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.022 0.042 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.007 0.043 -9999.0 0.0 -0.492 1.0 1.0 CYFIP2 0.003 0.071 -9999.0 0.0 -0.521 7.0 7.0 ENAH 0.047 0.064 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.022 0.158 -9999.0 0.0 -0.698 20.0 20.0 EPHA2 -0.001 0.106 -9999.0 0.0 -0.797 7.0 7.0 MYO6 0.028 0.046 -9999.0 0.0 -0.468 1.0 1.0 CTNNB1 0.01 0.042 -9999.0 0.0 -0.852 1.0 1.0 ABI1/Sra1/Nap1 -0.005 0.042 -9999.0 0.0 -0.573 1.0 1.0 AQP5 -0.143 0.19 -9999.0 0.0 -0.614 8.0 8.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.028 0.046 -9999.0 0.0 -0.459 1.0 1.0 regulation of calcium-dependent cell-cell adhesion 0.023 0.064 -9999.0 0.0 -0.533 3.0 3.0 EGF -0.078 0.257 -9999.0 0.0 -0.817 44.0 44.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.03 0.097 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization -0.007 0.043 -9999.0 0.0 -0.492 1.0 1.0 GO:0000145 0.026 0.044 -9999.0 0.0 -0.438 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.007 0.044 -9999.0 0.0 -0.498 1.0 1.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.014 0.066 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.02 0.082 -9999.0 0.0 -0.524 9.0 9.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.036 0.056 -9999.0 0.0 -0.486 2.0 2.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.028 0.046 -9999.0 0.0 -0.468 1.0 1.0 ARF6/GTP -0.011 0.071 -9999.0 0.0 -0.483 9.0 9.0 CDH1 -0.001 0.08 -9999.0 0.0 -0.466 12.0 12.0 EGFR/EGFR/EGF/EGF -0.069 0.165 -9999.0 0.0 -0.486 50.0 50.0 RhoA/GDP -0.007 0.04 -9999.0 0.0 -0.462 1.0 1.0 actin cytoskeleton organization 0.033 0.045 -9999.0 0.0 -0.43 1.0 1.0 IGF-1R heterotetramer 0.005 0.077 -9999.0 0.0 -0.754 4.0 4.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.005 0.077 -9999.0 0.0 -0.756 4.0 4.0 IGF1 -0.071 0.229 -9999.0 0.0 -0.641 53.0 53.0 DIAPH1 -0.009 0.065 -9999.0 0.0 -0.526 6.0 6.0 Wnt receptor signaling pathway 0.007 0.043 0.492 1.0 -9999.0 0.0 1.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.014 0.066 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.033 0.046 -9999.0 0.0 -0.441 1.0 1.0 EFNA1 0.006 0.073 -9999.0 0.0 -0.852 3.0 3.0 LPP 0.028 0.087 -9999.0 0.0 -0.719 4.0 4.0 Ephrin A1/EPHA2 -0.017 0.077 -9999.0 0.0 -0.453 10.0 10.0 SEC6/SEC8 -0.006 0.034 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.024 0.065 -9999.0 0.0 -0.545 3.0 3.0 HGF/MET -0.052 0.139 -9999.0 0.0 -0.465 39.0 39.0 HGF -0.008 0.119 -9999.0 0.0 -0.644 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.022 0.043 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.062 0.058 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.031 0.057 -9999.0 0.0 -0.448 2.0 2.0 KIFC3 0.028 0.046 -9999.0 0.0 -0.468 1.0 1.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.067 -9999.0 0.0 -0.527 4.0 4.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.007 0.043 -9999.0 0.0 -0.492 1.0 1.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.028 0.046 -9999.0 0.0 -0.468 1.0 1.0 PIP5K1C 0.028 0.046 -9999.0 0.0 -0.468 1.0 1.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.043 0.07 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.045 0.055 -9999.0 0.0 -0.451 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.05 0.131 -9999.0 0.0 -0.484 28.0 28.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.055 0.232 -9999.0 0.0 -0.84 33.0 33.0 PLEKHA7 0.027 0.048 -9999.0 0.0 -0.468 1.0 1.0 mol:GTP -0.012 0.076 -9999.0 0.0 -0.52 9.0 9.0 establishment of epithelial cell apical/basal polarity 0.051 0.041 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.022 0.042 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.033 0.045 -9999.0 0.0 -0.43 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.022 0.043 -9999.0 0.0 -9999.0 0.0 0.0