E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.002 0.091 -9999.0 0.0 -0.358 18.0 18.0 KLHL20 0.026 0.064 0.18 12.0 -0.204 3.0 15.0 CYFIP2 0.02 0.053 -9999.0 0.0 -0.381 7.0 7.0 Rac1/GDP 0.034 0.084 0.249 14.0 -0.28 2.0 16.0 ENAH 0.004 0.089 -9999.0 0.0 -0.369 16.0 16.0 AP1M1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.016 0.038 -9999.0 0.0 -0.219 1.0 1.0 ABI1/Sra1/Nap1 -0.01 0.029 -9999.0 0.0 -0.155 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.054 0.049 -9999.0 0.0 -0.202 10.0 10.0 RAPGEF1 0.017 0.096 0.232 7.0 -0.329 15.0 22.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.008 0.098 -9999.0 0.0 -0.364 20.0 20.0 CRK 0.016 0.092 -9999.0 0.0 -0.351 15.0 15.0 E-cadherin/gamma catenin/alpha catenin 0.042 0.045 -9999.0 0.0 -0.227 9.0 9.0 alphaE/beta7 Integrin 0.037 0.02 -9999.0 0.0 -0.271 1.0 1.0 IQGAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.018 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.003 0.091 -9999.0 0.0 -0.362 18.0 18.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.001 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.043 0.042 -9999.0 0.0 -0.198 10.0 10.0 PI3K 0.004 0.031 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.03 0.047 -9999.0 0.0 -0.271 9.0 9.0 TIAM1 0.017 0.062 -9999.0 0.0 -0.372 10.0 10.0 E-cadherin(dimer)/Ca2+ 0.052 0.043 -9999.0 0.0 -0.191 9.0 9.0 AKT1 0.005 0.038 0.131 4.0 -9999.0 0.0 4.0 PIK3R1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.018 0.06 -9999.0 0.0 -0.385 9.0 9.0 RhoA/GDP 0.041 0.087 0.244 19.0 -0.272 2.0 21.0 actin cytoskeleton organization 0.024 0.053 0.157 18.0 -0.153 1.0 19.0 CDC42/GDP 0.04 0.087 0.251 17.0 -0.268 3.0 20.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.013 0.035 -9999.0 0.0 -0.208 9.0 9.0 ITGB7 0.026 0.021 -9999.0 0.0 -0.385 1.0 1.0 RAC1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.056 0.047 -9999.0 0.0 -0.204 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.038 -9999.0 0.0 -0.188 9.0 9.0 mol:GDP 0.028 0.095 0.259 16.0 -0.28 9.0 25.0 CDC42/GTP/IQGAP1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.049 0.088 0.24 22.0 -0.266 2.0 24.0 RAC1/GTP/IQGAP1 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.02 0.039 0.131 14.0 -0.142 1.0 15.0 NME1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.003 0.091 -9999.0 0.0 -0.36 19.0 19.0 regulation of cell-cell adhesion 0.01 0.031 -9999.0 0.0 -0.194 1.0 1.0 WASF2 0.012 0.025 0.089 1.0 -9999.0 0.0 1.0 Rap1/GTP 0.036 0.064 0.277 3.0 -0.242 1.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.053 -9999.0 0.0 -0.198 7.0 7.0 CCND1 0.022 0.046 0.156 12.0 -0.173 1.0 13.0 VAV2 0.02 0.134 -9999.0 0.0 -0.532 10.0 10.0 RAP1/GDP 0.046 0.078 0.25 14.0 -0.254 1.0 15.0 adherens junction assembly 0.004 0.089 -9999.0 0.0 -0.35 19.0 19.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.052 0.054 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.004 0.048 -9999.0 0.0 -0.277 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.001 0.089 -9999.0 0.0 -0.362 18.0 18.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.004 0.066 -9999.0 0.0 -0.305 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.044 0.044 -9999.0 0.0 -0.224 9.0 9.0 ITGAE 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.008 0.1 -9999.0 0.0 -0.372 20.0 20.0