Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.039 0.166 -9999.0 0.0 -0.543 27.0 27.0 IHH -0.028 0.152 -9999.0 0.0 -0.431 48.0 48.0 SHH Np/Cholesterol/GAS1 -0.017 0.095 -9999.0 0.0 -0.219 71.0 71.0 LRPAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.017 0.094 0.218 71.0 -9999.0 0.0 71.0 SMO/beta Arrestin2 -0.027 0.165 -9999.0 0.0 -0.496 26.0 26.0 SMO -0.042 0.162 -9999.0 0.0 -0.513 27.0 27.0 AKT1 -0.025 0.146 -9999.0 0.0 -0.526 21.0 21.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.014 0.123 -9999.0 0.0 -0.384 41.0 41.0 ADRBK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.039 0.16 -9999.0 0.0 -0.504 27.0 27.0 STIL -0.056 0.137 -9999.0 0.0 -0.376 40.0 40.0 DHH N/PTCH2 -0.005 0.106 -9999.0 0.0 -0.252 64.0 64.0 DHH N/PTCH1 -0.016 0.134 -9999.0 0.0 -0.377 31.0 31.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.016 0.067 -9999.0 0.0 -0.385 11.0 11.0 PTHLH -0.062 0.229 -9999.0 0.0 -0.757 32.0 32.0 determination of left/right symmetry -0.039 0.16 -9999.0 0.0 -0.504 27.0 27.0 PIK3R1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.061 0.226 -9999.0 0.0 -0.748 32.0 32.0 IHH N/Hhip -0.067 0.174 -9999.0 0.0 -0.335 113.0 113.0 DHH N/Hhip -0.039 0.139 -9999.0 0.0 -0.282 99.0 99.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.039 0.16 -9999.0 0.0 -0.504 27.0 27.0 pancreas development -0.067 0.172 -9999.0 0.0 -0.384 94.0 94.0 HHAT 0.021 0.05 -9999.0 0.0 -0.385 6.0 6.0 PI3K 0.036 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.021 0.131 -9999.0 0.0 -0.382 48.0 48.0 somite specification -0.039 0.16 -9999.0 0.0 -0.504 27.0 27.0 SHH Np/Cholesterol/PTCH1 -0.031 0.125 -9999.0 0.0 -0.399 23.0 23.0 SHH Np/Cholesterol/PTCH2 -0.022 0.094 -9999.0 0.0 -0.202 85.0 85.0 SHH Np/Cholesterol/Megalin -0.019 0.092 -9999.0 0.0 -0.203 79.0 79.0 SHH -0.012 0.082 -9999.0 0.0 -0.281 34.0 34.0 catabolic process -0.026 0.135 -9999.0 0.0 -0.411 27.0 27.0 SMO/Vitamin D3 -0.038 0.147 -9999.0 0.0 -0.463 25.0 25.0 SHH Np/Cholesterol/Hhip -0.043 0.122 -9999.0 0.0 -0.241 105.0 105.0 LRP2 -0.025 0.129 -9999.0 0.0 -0.353 55.0 55.0 receptor-mediated endocytosis -0.052 0.142 -9999.0 0.0 -0.437 28.0 28.0 SHH Np/Cholesterol/BOC -0.013 0.093 -9999.0 0.0 -0.22 65.0 65.0 SHH Np/Cholesterol/CDO 0.001 0.072 -9999.0 0.0 -0.21 41.0 41.0 mesenchymal cell differentiation 0.043 0.121 0.239 105.0 -9999.0 0.0 105.0 mol:Vitamin D3 -0.029 0.128 -9999.0 0.0 -0.401 23.0 23.0 IHH N/PTCH2 -0.037 0.136 -9999.0 0.0 -0.27 99.0 99.0 CDON 0.018 0.058 -9999.0 0.0 -0.371 9.0 9.0 IHH N/PTCH1 -0.019 0.139 -9999.0 0.0 -0.415 27.0 27.0 Megalin/LRPAP1 -0.0 0.096 -9999.0 0.0 -0.246 54.0 54.0 PTCH2 -0.022 0.129 -9999.0 0.0 -0.355 54.0 54.0 SHH Np/Cholesterol -0.003 0.064 -9999.0 0.0 -0.212 34.0 34.0 PTCH1 -0.026 0.135 -9999.0 0.0 -0.413 27.0 27.0 HHIP -0.067 0.172 -9999.0 0.0 -0.385 94.0 94.0