Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.038 -9999.0 0.0 -0.215 9.0 9.0 epithelial cell differentiation 0.047 0.041 -9999.0 0.0 -0.189 9.0 9.0 CYFIP2 0.02 0.053 -9999.0 0.0 -0.381 7.0 7.0 ENAH -0.007 0.053 0.233 5.0 -0.242 1.0 6.0 EGFR 0.017 0.057 -9999.0 0.0 -0.385 8.0 8.0 EPHA2 0.021 0.047 -9999.0 0.0 -0.359 6.0 6.0 MYO6 -0.006 0.043 0.178 13.0 -9999.0 0.0 13.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.04 -9999.0 0.0 -0.223 7.0 7.0 AQP5 -0.101 0.181 -9999.0 0.0 -0.423 89.0 89.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.007 0.042 0.176 12.0 -9999.0 0.0 12.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.046 0.176 12.0 -0.338 1.0 13.0 EGF -0.016 0.118 -9999.0 0.0 -0.356 44.0 44.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.008 0.088 -9999.0 0.0 -0.418 13.0 13.0 cortical microtubule organization 0.047 0.041 -9999.0 0.0 -0.189 9.0 9.0 GO:0000145 -0.008 0.039 0.165 11.0 -9999.0 0.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.052 0.043 -9999.0 0.0 -0.191 9.0 9.0 MLLT4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.031 -9999.0 0.0 -0.326 1.0 1.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.039 -9999.0 0.0 -0.193 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.04 0.176 9.0 -0.327 1.0 10.0 PVRL2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.043 0.178 13.0 -9999.0 0.0 13.0 ARF6/GTP 0.064 0.042 -9999.0 0.0 -0.196 1.0 1.0 CDH1 0.018 0.06 -9999.0 0.0 -0.385 9.0 9.0 EGFR/EGFR/EGF/EGF 0.012 0.078 -9999.0 0.0 -0.343 2.0 2.0 RhoA/GDP 0.048 0.041 -9999.0 0.0 -0.186 6.0 6.0 actin cytoskeleton organization -0.007 0.04 0.165 13.0 -9999.0 0.0 13.0 IGF-1R heterotetramer 0.025 0.028 -9999.0 0.0 -0.369 2.0 2.0 GIT1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.028 -9999.0 0.0 -0.369 2.0 2.0 IGF1 -0.022 0.131 -9999.0 0.0 -0.371 51.0 51.0 DIAPH1 0.013 0.152 -9999.0 0.0 -0.53 19.0 19.0 Wnt receptor signaling pathway -0.047 0.041 0.189 9.0 -9999.0 0.0 9.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.03 -9999.0 0.0 -0.309 1.0 1.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.007 0.041 0.166 13.0 -9999.0 0.0 13.0 EFNA1 0.026 0.019 -9999.0 0.0 -0.353 1.0 1.0 LPP -0.011 0.047 0.173 9.0 -0.397 2.0 11.0 Ephrin A1/EPHA2 0.037 0.048 -9999.0 0.0 -0.351 1.0 1.0 SEC6/SEC8 -0.016 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.009 0.047 0.177 12.0 -0.343 1.0 13.0 HGF/MET 0.023 0.07 -9999.0 0.0 -0.335 2.0 2.0 HGF 0.014 0.07 -9999.0 0.0 -0.371 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.038 -9999.0 0.0 -0.217 9.0 9.0 actin cable formation 0.019 0.081 0.265 19.0 -0.345 1.0 20.0 KIAA1543 -0.007 0.041 0.166 13.0 -9999.0 0.0 13.0 KIFC3 -0.009 0.039 0.177 9.0 -9999.0 0.0 9.0 NCK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.008 0.046 0.178 12.0 -0.343 1.0 13.0 NCK1/GIT1 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.047 0.041 -9999.0 0.0 -0.189 9.0 9.0 EXOC4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.008 0.041 0.178 11.0 -9999.0 0.0 11.0 PIP5K1C -0.008 0.042 0.177 12.0 -9999.0 0.0 12.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.0 0.069 0.286 9.0 -0.278 1.0 10.0 adherens junction assembly -0.012 0.099 0.272 3.0 -0.66 6.0 9.0 IGF-1R heterotetramer/IGF1 0.014 0.082 -9999.0 0.0 -0.334 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.005 0.088 -9999.0 0.0 -0.355 23.0 23.0 PLEKHA7 -0.007 0.043 0.178 13.0 -9999.0 0.0 13.0 mol:GTP 0.057 0.038 -9999.0 0.0 -0.192 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.013 0.083 0.322 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.017 0.038 -9999.0 0.0 -0.215 9.0 9.0 regulation of cell-cell adhesion -0.007 0.04 0.165 13.0 -9999.0 0.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.038 -9999.0 0.0 -0.217 9.0 9.0