rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(40), AKT1(7), ATM(71), BAX(3), CDKN1A(7), CPB2(11), CSNK1A1(7), CSNK1D(5), FHL2(2), HIC1(11), HIF1A(10), HSPA1A(4), IGFBP3(7), MAPK8(7), MDM2(10), NFKBIB(8), NQO1(4), TP53(374) 17893088 588 409 375 41 145 76 53 118 187 9 <1.00e-15 <1.00e-15 <9.40e-14 2 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(11), ATM(71), BAX(3), BCL2(4), CCND1(3), CCNE1(7), CDK2(5), CDK4(2), CDKN1A(7), E2F1(6), MDM2(10), PCNA(2), RB1(22), TIMP3(12), TP53(374) 15654398 539 398 327 33 128 60 53 104 184 10 <1.00e-15 <1.00e-15 <9.40e-14 3 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(8), HSPA1A(4), IFNG(3), IFNGR1(11), IFNGR2(2), IKBKB(12), JAK2(14), LIN7A(11), NFKB1(10), NFKBIA(1), RB1(22), RELA(7), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TP53(374), USH1C(8), WT1(9) 15735204 509 387 306 53 131 55 46 98 173 6 <1.00e-15 <1.00e-15 <9.40e-14 4 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(59), DAXX(14), HRAS(2), PAX3(14), PML(20), RARA(4), RB1(22), SIRT1(13), SP100(26), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TP53(374) 16317424 561 385 354 46 151 57 61 100 187 5 <1.00e-15 <1.00e-15 <9.40e-14 5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(6), CCND1(3), CDK2(5), CDK4(2), CDKN1A(7), CDKN1B(1), CDKN2A(36), CFL1(2), E2F1(6), E2F2(7), MDM2(10), NXT1(4), PRB1(5), TP53(374) 7199165 468 372 259 22 121 54 40 82 164 7 <1.00e-15 <1.00e-15 <9.40e-14 6 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(10), DNAJC3(4), EIF2S1(3), EIF2S2(3), NFKB1(10), NFKBIA(1), RELA(7), TP53(374) 8514474 412 355 211 14 106 41 37 79 144 5 <1.00e-15 <1.00e-15 <9.40e-14 7 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(7), APAF1(11), ATM(71), BAD(4), BAX(3), BCL2(4), BCL2L1(2), BID(3), CASP3(2), CASP6(2), CASP7(5), CASP9(4), EIF2S1(3), PRKCA(9), PTK2(12), PXN(9), STAT1(14), TLN1(35), TP53(374) 23579568 574 403 366 41 158 68 53 108 179 8 <1.00e-15 1.11e-15 9.40e-14 8 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(10), MAX(4), MYC(6), SP1(6), SP3(7), TP53(374), WT1(9) 6045387 416 360 214 17 112 44 37 76 142 5 <1.00e-15 1.22e-15 9.40e-14 9 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(12), ATM(71), BRCA1(22), CDKN1A(7), CHEK1(7), CHEK2(13), JUN(6), MAPK8(7), MDM2(10), MRE11A(9), NFKB1(10), NFKBIA(1), RAD50(15), RAD51(4), RBBP8(8), RELA(7), TP53(374), TP73(9) 25517326 592 409 375 48 134 64 55 125 205 9 <1.00e-15 1.44e-15 9.88e-14 10 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(71), ATR(33), BRCA1(22), CCNB1(4), CDC25A(8), CDC25B(8), CDC25C(11), CDC34(2), CDKN1A(7), CDKN2D(5), CHEK1(7), CHEK2(13), EP300(39), MDM2(10), MYT1(26), PRKDC(70), RPS6KA1(10), TP53(374), WEE1(7), YWHAH(3), YWHAQ(5) 36402256 735 425 517 86 177 81 82 157 228 10 <1.00e-15 2.55e-15 1.56e-13 11 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(12), ATM(71), ATR(33), CCNA1(13), CCND1(3), CCNE1(7), CDC25A(8), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN1B(1), CDKN2A(36), CDKN2B(1), E2F1(6), GSK3B(9), HDAC1(10), RB1(22), SKP2(6), TFDP1(6), TGFB1(3), TGFB2(10), TGFB3(11), TP53(374) 25970061 662 417 445 76 148 74 66 131 234 9 <1.00e-15 3.11e-15 1.56e-13 12 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(71), CDC25A(8), CDC25B(8), CDC25C(11), CDK2(5), CDK4(2), CHEK1(7), MYT1(26), RB1(22), TP53(374), WEE1(7), YWHAH(3) 15170230 544 398 335 31 129 60 50 111 185 9 <1.00e-15 3.11e-15 1.56e-13 13 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(12), CDKN2A(36), E2F1(6), MDM2(10), MYC(6), PIK3CA(101), PIK3R1(17), POLR1A(23), POLR1B(11), POLR1C(9), POLR1D(4), RAC1(2), RB1(22), TBX2(12), TP53(374), TWIST1(5) 17421002 650 430 379 54 149 90 81 115 207 8 <1.00e-15 3.55e-15 1.56e-13 14 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(71), ATR(33), CDC25C(11), CHEK1(7), CHEK2(13), TP53(374), YWHAH(3) 13735609 512 388 303 26 124 49 49 103 178 9 <1.00e-15 3.55e-15 1.56e-13 15 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(11), BAK1(5), BAX(3), BCL2(4), BCL2L1(2), BID(3), BIRC2(8), BIRC3(12), CASP2(5), CASP3(2), CASP6(2), CASP7(5), CASP8(24), CASP9(4), FADD(4), FAS(3), FASLG(6), GZMB(2), JUN(6), MAP2K4(12), MAP3K1(24), MAPK10(7), MCL1(3), MDM2(10), MYC(6), NFKB1(10), NFKBIA(1), PARP1(15), PRF1(17), RELA(7), RIPK1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TNFSF10(10), TP53(374), TRADD(2), TRAF1(6), TRAF2(5) 32101837 638 414 421 74 160 72 60 123 215 8 <1.00e-15 3.89e-15 1.58e-13 16 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(71), ATR(33), BRCA1(22), BRCA2(48), CHEK1(7), CHEK2(13), FANCA(17), FANCC(8), FANCD2(18), FANCE(6), FANCF(2), FANCG(5), HUS1(2), MRE11A(9), RAD1(2), RAD17(10), RAD50(15), RAD51(4), RAD9A(5), TP53(374), TREX1(5) 37788271 676 414 458 57 144 72 68 143 236 13 <1.00e-15 4.11e-15 1.58e-13 17 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(7), BCL2(4), EGFR(24), IGF1R(24), MYC(6), POLR2A(27), PPP2CA(5), PRKCA(9), RB1(22), TEP1(39), TERF1(10), TERT(11), TNKS(23), TP53(374), XRCC5(14) 24253573 599 394 390 92 157 71 71 105 190 5 2.55e-15 5.88e-15 2.13e-13 18 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(7), ATF2(4), CDC42(3), DLD(14), DUSP10(11), DUSP4(3), DUSP8(2), GAB1(5), GCK(10), IL1R1(5), JUN(6), MAP2K4(12), MAP2K5(3), MAP2K7(38), MAP3K1(24), MAP3K10(17), MAP3K11(12), MAP3K12(17), MAP3K13(14), MAP3K2(9), MAP3K3(10), MAP3K4(32), MAP3K5(18), MAP3K7(14), MAP3K9(7), MAPK10(7), MAPK7(9), MAPK8(7), MAPK9(7), MYEF2(10), NFATC3(7), NR2C2(10), PAPPA(35), SHC1(7), TP53(374), TRAF6(7), ZAK(12) 43221375 789 421 572 106 218 94 76 156 237 8 <1.00e-15 1.98e-07 6.78e-06 19 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(11), ATM(71), ATR(33), BAI1(26), BAX(3), BID(3), CASP3(2), CASP8(24), CASP9(4), CCNB1(4), CCNB2(1), CCNB3(24), CCND1(3), CCND2(2), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CD82(3), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN2A(36), CHEK1(7), CHEK2(13), DDB2(3), EI24(2), FAS(3), GADD45B(3), GTSE1(7), IGF1(3), IGFBP3(7), MDM2(10), MDM4(5), PERP(5), PMAIP1(1), PPM1D(11), PTEN(43), RCHY1(4), RFWD2(9), RPRM(6), RRM2(3), RRM2B(5), SERPINB5(5), SERPINE1(3), SESN1(2), SESN2(5), SESN3(6), SFN(1), SIAH1(3), STEAP3(13), THBS1(19), TNFRSF10B(3), TP53(374), TP53I3(1), TP73(9), TSC2(21), ZMAT3(4) 56370297 901 459 664 126 222 104 87 182 292 14 <1.00e-15 4.25e-07 1.38e-05 20 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(11), BAD(4), BAK1(5), BAX(3), BCL2(4), BCL2L1(2), BCL2L11(7), BID(3), BIRC2(8), BIRC3(12), BIRC5(3), BNIP3L(1), CASP1(8), CASP10(8), CASP2(5), CASP3(2), CASP4(7), CASP6(2), CASP7(5), CASP8(24), CASP9(4), CHUK(10), DFFA(5), DFFB(5), FADD(4), FAS(3), FASLG(6), GZMB(2), HELLS(9), IKBKB(12), IRF1(6), IRF2(24), IRF3(3), IRF4(12), IRF5(7), IRF6(9), IRF7(4), JUN(6), LTA(4), MAP2K4(12), MAP3K1(24), MAPK10(7), MDM2(10), MYC(6), NFKB1(10), NFKBIA(1), NFKBIB(8), NFKBIE(1), PLEKHG5(13), PRF1(17), RELA(7), RIPK1(5), TNF(3), TNFRSF10B(3), TNFRSF1A(6), TNFRSF1B(4), TNFRSF21(6), TNFRSF25(9), TNFSF10(10), TP53(374), TP73(9), TRADD(2), TRAF1(6), TRAF2(5), TRAF3(8) 49308665 825 439 601 117 211 93 86 167 260 8 <1.00e-15 1.19e-05 0.000366 21 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(15) 619862 15 15 13 1 6 1 2 1 5 0 0.0554 0.000522 0.0153 22 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(7), PIK3CA(101), PIK3R1(17), PLCB1(24), PLCG1(27), PRKCA(9), VAV1(21) 11100491 206 138 141 20 43 49 41 38 34 1 1.30e-11 0.00137 0.0383 23 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(2), CD3E(3), CD80(6), CD86(8), CTLA4(4), GRB2(4), HLA-DRA(7), HLA-DRB1(2), ICOS(4), ITK(12), LCK(5), PIK3CA(101), PIK3R1(17), PTPN11(10) 11011477 185 134 121 21 33 42 40 43 26 1 1.81e-08 0.0265 0.709 24 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(16), FMOD(14), KERA(7), LUM(11) 3111171 50 43 49 4 16 4 5 20 5 0 0.000950 0.0517 1.000 25 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(4), AKT1(7), AKT2(11), AKT3(10), APAF1(11), ATM(71), BAD(4), BAX(3), BCL2(4), BCL2L1(2), BID(3), BIRC2(8), BIRC3(12), CAPN1(8), CAPN2(11), CASP10(8), CASP3(2), CASP6(2), CASP7(5), CASP8(24), CASP9(4), CFLAR(3), CHUK(10), CSF2RB(18), DFFA(5), DFFB(5), ENDOG(2), FADD(4), FAS(3), FASLG(6), IKBKB(12), IL1A(2), IL1B(7), IL1R1(5), IL1RAP(8), IL3(3), IL3RA(6), IRAK1(9), IRAK2(11), IRAK3(10), IRAK4(4), MYD88(4), NFKB1(10), NFKB2(11), NFKBIA(1), NTRK1(14), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKACA(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RELA(7), RIPK1(5), TNF(3), TNFRSF10A(3), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(10), TP53(374), TRADD(2), TRAF2(5) 72131837 1120 468 825 160 275 160 127 225 321 12 <1.00e-15 0.107 1.000 26 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(7), BCAR1(16), CDKN1B(1), GRB2(4), ILK(11), ITGB1(12), MAPK1(4), MAPK3(3), PDK2(2), PDPK1(1), PIK3CA(101), PIK3R1(17), PTEN(43), PTK2(12), SHC1(7), SOS1(12) 16642798 253 164 178 29 42 52 45 52 57 5 6.49e-10 0.153 1.000 27 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(12), ERBB4(76), NRG2(11), NRG3(32), PRKCA(9), PSEN1(7) 7805995 147 109 134 24 32 15 27 44 29 0 0.00127 0.178 1.000 28 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(27), HLA-A(23), IL18(1), ITGB1(12), KLRC1(4), KLRC2(2), KLRC3(10), KLRC4(1), KLRD1(5), LAT(3), MAP2K1(9), MAPK3(3), PAK1(7), PIK3CA(101), PIK3R1(17), PTK2B(20), PTPN6(6), RAC1(2), SYK(11), VAV1(21) 16150791 285 164 203 32 43 58 46 60 71 7 1.16e-10 0.281 1.000 29 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(7), CDC34(2), CDK2(5), CUL1(28), E2F1(6), FBXW7(46), RB1(22), TFDP1(6) 7204416 122 90 105 14 31 12 16 18 45 0 1.10e-05 0.302 1.000 30 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(7), GRB2(4), HRAS(2), KLK2(2), NTRK1(14), PIK3CA(101), PIK3R1(17), PLCG1(27), PRKCA(9), SHC1(7), SOS1(12) 13440759 202 139 139 25 46 48 41 39 27 1 2.31e-09 0.372 1.000 31 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(7), GRIA2(34), JUND(2), PPP1R1B(3) 3217314 49 41 49 7 8 10 7 17 7 0 0.0105 0.416 1.000 32 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(7), BAD(4), CASP9(4), CHUK(10), GH1(3), GHR(11), NFKB1(10), NFKBIA(1), PDPK1(1), PIK3CA(101), PIK3R1(17), PPP2CA(5), RELA(7), YWHAH(3) 12143126 184 129 123 27 27 50 45 35 26 1 2.89e-07 0.518 1.000 33 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(9), GSTZ1(2), HGD(8) 1923828 19 19 17 3 5 1 3 4 6 0 0.251 0.556 1.000 34 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(5), LIPT1(5) 1307022 10 10 9 1 2 3 1 0 3 1 0.182 0.583 1.000 35 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(14), AOC3(18), CES1(21), ESD(1) 5206909 54 48 51 6 16 4 4 13 17 0 0.0182 0.794 1.000 36 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(8), TPI1(3) 1411081 11 11 11 2 5 2 1 2 1 0 0.253 0.835 1.000 37 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(71), CCNA1(13), CCNB1(4), CCND1(3), CCND2(2), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(8), CDK2(5), CDK4(2), CDKN1A(7), CDKN1B(1), CDKN2A(36), CDKN2B(1), CDKN2C(2), CDKN2D(5), CREB3L1(7), CREB3L3(6), CREB3L4(4), E2F1(6), E2F2(7), E2F3(4), E2F4(2), E2F5(5), E2F6(1), GBA2(7), MCM2(15), MCM3(8), MCM4(17), MCM5(11), MCM6(13), MCM7(8), MDM2(10), MNAT1(4), MYC(6), MYT1(26), NACA(26), PCNA(2), POLA2(6), POLE(42), POLE2(6), PRIM1(6), RB1(22), RBL1(14), RPA1(6), RPA2(4), RPA3(1), TFDP1(6), TFDP2(8), TNXB(82), TP53(374), WEE1(7) 66461413 954 445 727 153 256 114 94 195 285 10 <1.00e-15 0.851 1.000 38 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), PAK1(7), PDGFRA(17), PIK3CA(101), PIK3R1(17), RAC1(2), WASL(7) 11574855 170 122 110 27 21 44 41 33 30 1 1.54e-05 0.878 1.000 39 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(4), CASP3(2), CASP8(24), CFL1(2), CFLAR(3), PDE6D(1) 3284168 36 30 33 6 3 6 5 8 14 0 0.219 0.892 1.000 40 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(3), TGDS(7), UGDH(11), UXS1(9) 3359335 32 29 31 4 9 3 6 8 6 0 0.0352 0.905 1.000 41 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(9), AKT1(7), ANXA1(6), CALM1(2), CALM2(3), CALM3(2), GNAS(54), GNB1(2), GNGT1(4), NFKB1(10), NOS3(20), NPPA(2), NR3C1(10), PIK3CA(101), PIK3R1(17), RELA(7), SYT1(8) 15501955 264 173 190 35 71 53 42 54 43 1 4.23e-09 0.935 1.000 42 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(4), SEC61A2(5), SRP19(3), SRP54(11), SRP68(8), SRP72(16), SRP9(2), SRPR(18) 6486893 67 55 64 6 16 9 12 11 19 0 0.000999 0.940 1.000 43 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(9), CCL2(1), CSF1(6), IL6(1), LDLR(15), LPL(11) 4576270 43 39 39 7 11 5 4 6 17 0 0.0268 0.953 1.000 44 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(3) 978854 3 3 3 1 0 0 2 1 0 0 0.686 0.972 1.000 45 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(3), TGDS(7), UGDH(11), UGP2(9), UXS1(9) 4259646 41 34 39 5 11 3 6 10 11 0 0.0289 0.979 1.000 46 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3E(3), IFNG(3), IL2RA(3), IL4(4), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TGFBR2(32), TGFBR3(12), TOB1(3), TOB2(7) 9050386 103 89 95 20 18 10 19 26 30 0 0.0583 0.983 1.000 47 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(5), FDPS(14), IDI1(3), SQLE(10) 2790299 32 25 31 5 7 4 4 8 9 0 0.0756 0.983 1.000 48 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(8), ALDOA(1), ALDOB(11), ALDOC(11), TPI1(3) 3349434 34 33 34 6 8 8 4 10 4 0 0.0612 0.987 1.000 49 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(4), CCR3(14), HLA-DRA(7), HLA-DRB1(2), IL3(3) 2621576 31 25 29 7 11 4 3 7 6 0 0.150 0.990 1.000 50 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(7), BAD(4), BCL2L1(2), CASP9(4), CDC42(3), CHUK(10), ELK1(6), H2AFX(1), HRAS(2), MAP2K1(9), MAPK3(3), NFKB1(10), PIK3CA(101), PIK3R1(17), RAC1(2), RAF1(11), RALA(1), RALBP1(12), RALGDS(14), RELA(7), RHOA(23) 16630578 249 158 178 38 48 58 52 52 38 1 8.82e-09 0.990 1.000 51 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(8), ACADM(7), ACADS(6), ACAT1(9), ECHS1(3), HADHA(7) 4687363 40 34 37 5 8 7 5 8 12 0 0.0272 0.991 1.000 52 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(7), CDK2(5), CDKN1B(1), CKS1B(2), CUL1(28), E2F1(6), NEDD8(2), RB1(22), RBX1(1), SKP2(6), TFDP1(6), UBE2M(2) 7430168 88 68 87 14 10 12 16 16 34 0 0.00567 0.994 1.000 53 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), JUN(6), KLK2(2), MAP2K1(9), MAPK3(3), MAPK8(7), NGFR(9), PIK3CA(101), PIK3R1(17), PLCG1(27), RAF1(11), SHC1(7), SOS1(12) 16478213 231 147 166 32 52 51 44 50 33 1 2.71e-09 0.995 1.000 54 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(8), CHRNA1(11), SNAP25(3), STX1A(6), VAMP2(1) 2793694 29 27 28 6 12 1 3 8 5 0 0.216 0.995 1.000 55 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(5), FDPS(14), GGPS1(4), IDI1(3), IDI2(4), SQLE(10) 3720062 40 29 39 6 9 5 4 10 12 0 0.0527 0.997 1.000 56 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(11), ARHGAP5(34), ARHGDIB(1), CASP1(8), CASP10(8), CASP3(2), CASP8(24), CASP9(4), GZMB(2), JUN(6), PRF1(17) 11063332 117 85 109 14 21 15 15 28 35 3 0.00119 0.997 1.000 57 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(6), BCKDK(8), CBS(9), CTH(3), MUT(10) 4197717 36 34 35 6 7 4 4 5 16 0 0.119 0.998 1.000 58 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(14), CD4(11), HLA-DRA(7), HLA-DRB1(2), IL1B(7), IL4(4), IL5RA(12), IL6(1) 4590639 59 48 52 14 12 7 7 13 20 0 0.191 0.999 1.000 59 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(9), ACAT2(6), OXCT1(10) 2928835 25 24 23 7 3 8 2 3 9 0 0.691 0.999 1.000 60 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(8), IFNG(3), IL12A(3), IL12B(3), IL18(1) 2565850 18 17 18 5 2 3 2 9 2 0 0.608 0.999 1.000 61 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(40), ABCB11(17), ABCB4(33), ABCC1(17), ABCC3(16), GSTP1(2) 12426372 125 95 116 16 26 16 15 28 40 0 9.51e-05 0.999 1.000 62 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(9), SUCLA2(3) 1846978 12 12 12 3 6 1 1 1 3 0 0.437 0.999 1.000 63 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(68), CDH1(34), CREBBP(59), EP300(39), MAP2K1(9), MAP3K7(14), MAPK3(3), SKIL(9), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TGFBR2(32) 21852978 301 192 272 54 55 33 42 70 97 4 0.000263 0.999 1.000 64 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(5), LPL(11), NR3C1(10), PPARG(6), RETN(2), RXRA(13), TNF(3) 4959007 50 46 46 12 14 4 6 12 14 0 0.235 1.000 1.000 65 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(5), HLCS(9), SPCS1(2), SPCS3(3) 2612688 19 17 19 6 4 1 1 11 2 0 0.605 1.000 1.000 66 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(13), CCNE1(7), CDC34(2), CDK2(5), CUL1(28), E2F1(6), RB1(22), SKP2(6), TFDP1(6) 7443450 95 77 94 21 13 13 18 19 32 0 0.0371 1.000 1.000 67 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), INSR(26), IRS1(33), JUN(6), MAP2K1(9), MAPK3(3), MAPK8(7), PIK3CA(101), PIK3R1(17), PTPN11(10), RAF1(11), RASA1(28), SHC1(7), SLC2A4(5), SOS1(12), SRF(5) 21915483 300 175 228 43 58 63 51 59 65 4 4.08e-10 1.000 1.000 68 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(7), EIF4A1(4), EIF4A2(8), EIF4E(2), EIF4EBP1(5), EIF4G1(31), EIF4G2(1), EIF4G3(26), GHR(11), IRS1(33), MAPK1(4), MAPK14(3), MAPK3(3), MKNK1(6), PABPC1(12), PDK2(2), PDPK1(1), PIK3CA(101), PIK3R1(17), PRKCA(9), PTEN(43), RPS6KB1(6) 24259206 335 189 254 45 51 67 58 60 92 7 3.37e-09 1.000 1.000 69 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(7), APC(68), AXIN1(17), CCND1(3), CD14(2), CTNNB1(36), DVL1(8), FZD1(15), GJA1(14), GNAI1(4), GSK3B(9), IRAK1(9), LBP(3), LEF1(5), LY96(5), MYD88(4), NFKB1(10), PDPK1(1), PIK3CA(101), PIK3R1(17), PPP2CA(5), RELA(7), TIRAP(1), TLR4(33), TOLLIP(7), WNT1(11) 26237351 402 226 315 72 62 71 67 95 100 7 8.12e-08 1.000 1.000 70 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(8), SLPI(2) 1462374 10 9 10 5 6 1 0 1 2 0 0.740 1.000 1.000 71 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(9), ACAT2(6), ACYP1(2), ACYP2(3), ECHS1(3), EHHADH(5), GCDH(8), HADHA(7), SDHB(4), SDS(5) 6753528 52 40 47 9 8 12 8 7 17 0 0.0519 1.000 1.000 72 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(3), BAK1(5), BAX(3), BFAR(5), BTK(5), CAD(31), CASP10(8), CASP3(2), CASP8(24), CD7(6), CDK2AP1(1), CSNK1A1(7), DAXX(14), DEDD(4), DEDD2(4), DFFA(5), DIABLO(1), EGFR(24), EPHB2(19), FADD(4), FAF1(13), FAIM2(2), HSPB1(2), IL1A(2), MAP2K4(12), MAP2K7(38), MAP3K1(24), MAP3K5(18), MAPK1(4), MAPK10(7), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), MET(14), NFAT5(17), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR0B2(4), PFN1(1), PFN2(1), PTPN13(41), RALBP1(12), RIPK1(5), ROCK1(22), SMPD1(8), TP53(374), TPX2(10), TRAF2(5) 62806880 890 432 668 155 243 103 93 168 271 12 6.00e-15 1.000 1.000 73 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(71), CDC25A(8), CDC25B(8), CDC25C(11), CHEK1(7), MYT1(26), WEE1(7), YWHAH(3) 11857508 141 96 133 26 29 20 12 39 37 4 0.0166 1.000 1.000 74 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(4), FOS(2), JUN(6), KEAP1(17), MAFF(1), MAPK1(4), MAPK14(3), MAPK8(7), NFE2L2(20), PRKCA(9) 7777710 73 62 68 14 15 16 11 18 13 0 0.00939 1.000 1.000 75 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(2), GGT1(9), SHMT1(4), SHMT2(13) 3626302 28 25 25 9 8 3 3 3 11 0 0.451 1.000 1.000 76 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(3), ASL(8), CPS1(35), GLS(13), GLUD1(5), GOT1(3) 6717965 67 55 65 13 17 7 9 25 9 0 0.0444 1.000 1.000 77 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(7), AKT2(11), AKT3(10), BPNT1(6), GRB2(4), ILK(11), MAPK1(4), MAPK3(3), PDK1(3), PIK3CA(101), PIK3CD(20), PTEN(43), PTK2B(20), RBL2(11), SHC1(7), SOS1(12) 17483441 273 165 199 45 56 59 41 58 55 4 4.35e-06 1.000 1.000 78 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(6), IL1B(7), MST1R(20), TNF(3) 5616470 37 30 36 5 4 8 0 10 15 0 0.0425 1.000 1.000 79 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(4), CDC25A(8), CDC25B(8), CDC25C(11), CSK(10), GRB2(4), PRKCA(9), PTPRA(19), SRC(5) 7968717 78 59 74 14 23 8 9 16 21 1 0.0170 1.000 1.000 80 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(5), CALM1(2), CALM2(3), CALM3(2), ELK1(6), FCER1A(5), FOS(2), GRB2(4), HRAS(2), JUN(6), LYN(9), MAP2K1(9), MAP2K4(12), MAP2K7(38), MAP3K1(24), MAPK1(4), MAPK3(3), MAPK8(7), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), PAK2(13), PIK3CA(101), PIK3R1(17), PLA2G4A(8), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), RAF1(11), SHC1(7), SOS1(12), SYK(11), SYT1(8), VAV1(21) 36917400 489 228 411 70 138 85 69 92 100 5 <1.00e-15 1.000 1.000 81 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(5), BIRC3(12), CASP8(24), FADD(4), RIPK1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF2(5) 7185557 70 57 66 16 12 9 8 12 28 1 0.229 1.000 1.000 82 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(27), CD3E(3), GZMB(2), HLA-A(23), ICAM1(5), ITGAL(28), ITGB2(12), PRF1(17) 7484393 117 78 100 29 22 11 10 22 46 6 0.235 1.000 1.000 83 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(8), CYP2C9(5) 1748393 13 11 13 5 5 1 1 5 1 0 0.830 1.000 1.000 84 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(4), CREBBP(59), EP300(39), FYN(10), IL2RG(12), IL7(2), IL7R(18), JAK1(22), JAK3(18), LCK(5), NMI(2), PIK3CA(101), PIK3R1(17), PTK2B(20), STAT5A(13), STAT5B(15) 24030791 357 188 279 54 69 65 57 78 85 3 4.94e-09 1.000 1.000 85 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), MIOX(8), UGDH(11) 7276367 87 61 75 19 19 9 11 20 28 0 0.122 1.000 1.000 86 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(47), GNA12(2), PRKACB(6), PRKACG(9), PRKAG1(6), PRKAR2A(3), PRKAR2B(12) 8621689 85 68 80 16 14 15 11 19 24 2 0.0499 1.000 1.000 87 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(7), FOS(2), FYN(10), JUN(6), MAPK14(3), THBS1(19) 6330837 49 42 46 10 10 7 10 12 10 0 0.104 1.000 1.000 88 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(6), GBA(14), GGT1(9), SHMT1(4), SHMT2(13) 4796538 46 39 43 10 14 4 7 7 14 0 0.100 1.000 1.000 89 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(6), ECHS1(3), EHHADH(5), HADHA(7), SDS(5) 4186499 26 23 25 7 6 4 3 7 6 0 0.268 1.000 1.000 90 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2), TAT(7) 2258060 12 12 12 9 4 2 1 3 2 0 0.955 1.000 1.000 91 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAA2(13), ACAT1(9), ACAT2(6), ECHS1(3), EHHADH(5), HADHA(7), HADHB(6), SDS(5) 7227484 57 42 54 10 7 13 11 7 19 0 0.0285 1.000 1.000 92 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(8), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT5(5), FUT8(11), ST3GAL1(7), ST3GAL2(11), ST3GAL3(3), ST3GAL4(8) 6751311 72 66 71 16 25 11 8 18 10 0 0.0849 1.000 1.000 93 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(9), AASDHPPT(1), AASS(13), KARS(9) 4067313 32 26 31 9 7 7 5 8 5 0 0.405 1.000 1.000 94 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(43), C5(15), C6(19), C7(11), C8A(13), C9(10) 10855957 111 79 105 26 26 18 14 32 21 0 0.0580 1.000 1.000 95 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(11), BAK1(5), BAX(3), BCL2(4), BCL2L1(2), BID(3), BIK(1), BIRC2(8), BIRC3(12), CASP3(2), CASP6(2), CASP7(5), CASP8(24), CASP9(4), DFFA(5), DFFB(5), DIABLO(1), ENDOG(2) 11705120 99 71 94 16 19 15 14 22 29 0 0.0105 1.000 1.000 96 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(7), EIF4A1(4), EIF4A2(8), EIF4B(5), EIF4E(2), EIF4EBP1(5), EIF4G1(31), EIF4G2(1), EIF4G3(26), FKBP1A(2), MKNK1(6), PDK2(2), PDPK1(1), PIK3CA(101), PIK3R1(17), PPP2CA(5), PTEN(43), RPS6(1), RPS6KB1(6), TSC1(20), TSC2(21) 23877138 314 182 238 47 54 57 59 62 76 6 5.53e-08 1.000 1.000 97 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(7), CREB1(4), GRB2(4), HRAS(2), MAPK1(4), MAPK3(3), MAPK7(9), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), NTRK1(14), PIK3CA(101), PIK3R1(17), PLCG1(27), RPS6KA1(10), SHC1(7) 16485447 236 148 173 40 55 57 46 40 37 1 8.71e-08 1.000 1.000 98 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(7), EIF2B5(11), EIF2S1(3), EIF2S2(3), EIF2S3(3), EIF4E(2), EIF4EBP1(5), GSK3B(9), IGF1(3), IGF1R(24), INPPL1(29), PDK2(2), PDPK1(1), PIK3CA(101), PIK3R1(17), PPP2CA(5), PTEN(43), RPS6(1), RPS6KB1(6) 17021562 275 159 195 48 48 52 52 49 68 6 1.45e-05 1.000 1.000 99 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(11), BAD(4), BAK1(5), BAX(3), BCL10(3), BCL2(4), BCL2L1(2), BCL2L11(7), BID(3), CASP9(4), CES1(21) 9460139 67 51 66 12 22 14 6 15 10 0 0.0138 1.000 1.000 100 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(4), CCNH(3), CDC25A(8), CDC25B(8), CDC25C(11), MNAT1(4), SHH(6), XPO1(17) 7450212 61 45 55 14 14 12 4 15 15 1 0.199 1.000 1.000 101 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(11), F13A1(20), F2(15), F2R(10), FGA(16), FGB(9), FGG(6), PLAT(8), PLG(21), SERPINB2(11), SERPINE1(3) 11547958 130 93 124 29 37 12 16 36 29 0 0.0352 1.000 1.000 102 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(6), COASY(5), DPYD(25), DPYS(12), ENPP1(12), ENPP3(16), PANK1(14), PANK2(10), PANK3(6), PANK4(9), PPCS(2), UPB1(6) 12031110 123 90 118 23 20 18 18 37 30 0 0.00352 1.000 1.000 103 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7) 6802335 85 60 74 23 21 8 8 18 30 0 0.343 1.000 1.000 104 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7) 6802335 85 60 74 23 21 8 8 18 30 0 0.343 1.000 1.000 105 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(8), F13B(20), HSD17B1(5), HSD17B2(3), HSD17B3(2), HSD17B4(11), HSD17B7(5), HSD3B1(6), HSD3B2(5) 6941058 65 49 64 17 9 12 11 21 12 0 0.187 1.000 1.000 106 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(7), CCND1(3), CCNE1(7), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN1B(1), E2F1(6), HRAS(2), MAPK1(4), MAPK3(3), NFKB1(10), NFKBIA(1), PAK1(7), PIK3CA(101), PIK3R1(17), RAC1(2), RAF1(11), RB1(22), RELA(7), TFDP1(6) 17475413 237 154 174 40 35 58 49 42 52 1 4.95e-07 1.000 1.000 107 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(6), FOS(2), GRB2(4), HRAS(2), JAK2(14), JUN(6), MAP2K1(9), MAPK3(3), MPL(7), PIK3CA(101), PIK3R1(17), PLCG1(27), PRKCA(9), RAF1(11), RASA1(28), SHC1(7), SOS1(12), STAT1(14), STAT3(9), STAT5A(13), STAT5B(15), THPO(8) 25838881 324 177 255 46 71 65 51 70 64 3 4.98e-10 1.000 1.000 108 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(16), CRK(2), CXCR4(1), GNAI1(4), GNAQ(4), GNB1(2), GNGT1(4), HRAS(2), MAP2K1(9), MAPK1(4), MAPK3(3), NFKB1(10), PIK3C2G(18), PIK3CA(101), PIK3R1(17), PLCG1(27), PRKCA(9), PTK2(12), PTK2B(20), PXN(9), RAF1(11), RELA(7) 23959532 292 178 225 45 70 60 49 54 58 1 1.32e-09 1.000 1.000 109 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(5), RANBP1(1), RANBP2(42), RANGAP1(15) 7305308 63 48 62 17 8 12 14 15 12 2 0.214 1.000 1.000 110 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(7), CAT(6), GH1(3), GHR(11), HRAS(2), IGF1(3), IGF1R(24), PIK3CA(101), PIK3R1(17), SHC1(7), SOD2(2) 11310996 183 126 123 38 29 50 46 33 24 1 0.000121 1.000 1.000 111 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), JAK1(22), JUN(6), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK3(3), MAPK8(7), PDGFA(4), PDGFRA(17), PIK3CA(101), PIK3R1(17), PLCG1(27), PRKCA(9), RAF1(11), RASA1(28), SHC1(7), SOS1(12), SRF(5), STAT1(14), STAT3(9), STAT5A(13) 30113400 377 197 301 58 78 71 60 75 88 5 3.28e-10 1.000 1.000 112 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(11), CD80(6), HLA-DRA(7), HLA-DRB1(2), IL10(4), IL4(4) 3410663 36 35 30 11 11 2 3 9 11 0 0.659 1.000 1.000 113 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(26), GNAS(54), GNB1(2), GNGT1(4), PRKACA(9), PRKAR1A(4) 5712533 99 76 91 26 45 7 3 24 19 1 0.286 1.000 1.000 114 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(5), CREBBP(59), DFFA(5), DFFB(5), GZMA(5), GZMB(2), HMGB2(4), PRF1(17), SET(10) 9089412 113 84 107 29 30 12 14 30 27 0 0.111 1.000 1.000 115 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(13), GLS2(8), GLUD1(5), GLUD2(17) 3894596 43 33 42 11 9 4 6 15 9 0 0.328 1.000 1.000 116 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(6), DAB1(17), FYN(10), LRP8(8), RELN(69), VLDLR(7) 12019659 120 86 116 25 26 24 17 35 18 0 0.00439 1.000 1.000 117 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(68), AXIN1(17), CREBBP(59), CTNNB1(36), DVL1(8), EP300(39), FZD1(15), GSK3B(9), HDAC1(10), LDB1(5), LEF1(5), PITX2(6), TRRAP(77), WNT1(11) 28265283 365 196 333 66 98 37 41 77 106 6 2.24e-06 1.000 1.000 118 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(8), GNAS(54), GNB1(2), GNGT1(4), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9) 8337604 121 92 110 27 55 11 4 22 28 1 0.0607 1.000 1.000 119 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(13), CCNA2(2), CCND1(3), CCNE1(7), CCNE2(3), CDK2(5), CDK4(2), CDKN1B(1), CDKN2A(36), E2F1(6), E2F2(7), E2F4(2), PRB1(5) 7717494 92 83 87 27 15 18 10 20 28 1 0.244 1.000 1.000 120 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(9), ST3GAL1(7), ST3GAL2(11), ST3GAL4(8), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(3), ST8SIA1(12) 4791164 54 48 52 17 22 2 9 14 7 0 0.379 1.000 1.000 121 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(13), ECHS1(3), HADH(3), HADHA(7), HADHB(6), HSD17B4(11), MECR(4), PPT1(6), PPT2(4) 7321608 57 40 56 10 10 11 12 8 16 0 0.00997 1.000 1.000 122 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(6), CDO1(3), CSAD(9), GAD1(11), GAD2(17), GGT1(9) 4980506 55 45 53 18 17 8 5 10 15 0 0.344 1.000 1.000 123 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(18), GBA(14), LPO(14), MPO(12), PRDX6(5), TPO(35) 7217196 98 83 95 25 31 13 9 28 16 1 0.113 1.000 1.000 124 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(28), GABRA2(18), GABRA3(12), GABRA4(12), GABRA5(12), GABRA6(18), PRKCE(16) 6817756 116 84 113 32 24 9 24 45 14 0 0.156 1.000 1.000 125 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(7), BAD(4), CHRNB1(10), CHRNG(11), MUSK(18), PIK3CA(101), PIK3R1(17), PTK2(12), PTK2B(20), RAPSN(5), SRC(5), TERT(11), YWHAH(3) 14181646 224 140 162 44 52 50 44 42 35 1 5.85e-06 1.000 1.000 126 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(19), APOBEC1(8), APOBEC2(5), APOBEC3B(5), APOBEC3C(1), APOBEC3F(3), APOBEC3G(5), APOBEC4(4) 6312982 50 38 49 10 14 9 6 14 7 0 0.0880 1.000 1.000 127 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(27), PRKCA(9), PTK2B(20) 5754319 61 50 57 14 28 7 3 8 15 0 0.0594 1.000 1.000 128 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(8), HLA-DRA(7), HLA-DRB1(2), IFNG(3), IFNGR1(11), IFNGR2(2), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL18(1), IL18R1(7), IL2RA(3), IL4(4), IL4R(10) 10892142 90 65 90 23 18 11 13 26 22 0 0.176 1.000 1.000 129 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(9), ACO2(12), FH(4), IDH1(5), IDH2(8), MDH1(5), MDH2(2), SDHB(4), SUCLA2(3) 7679196 52 41 51 11 16 11 4 9 12 0 0.105 1.000 1.000 130 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(7), AKT2(11), AKT3(10), CDKN1A(7), ELK1(6), GRB2(4), HRAS(2), MAP2K1(9), MAP2K2(6), NGFR(9), NTRK1(14), PIK3CA(101), PIK3CD(20), SHC1(7), SOS1(12) 14084278 225 151 160 47 56 55 40 56 18 0 1.71e-05 1.000 1.000 131 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B1(25), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), SHMT1(4) 12986990 136 89 119 27 29 17 18 29 42 1 0.0354 1.000 1.000 132 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B1(25), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), SHMT1(4) 12986990 136 89 119 27 29 17 18 29 42 1 0.0354 1.000 1.000 133 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B1(25), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), SHMT1(4) 12986990 136 89 119 27 29 17 18 29 42 1 0.0354 1.000 1.000 134 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(12), ATM(71), BUB1(15), BUB1B(16), BUB3(4), CCNA1(13), CCNA2(2), CCNB1(4), CCNB2(1), CCNB3(24), CCND2(2), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDAN1(17), CDC14A(21), CDC14B(8), CDC20(10), CDC25A(8), CDC25B(8), CDC25C(11), CDC6(13), CDC7(8), CDH1(34), CDK2(5), CDK4(2), CDKN1A(7), CDKN2A(36), CHEK1(7), CHEK2(13), DTX4(14), E2F1(6), E2F2(7), E2F3(4), E2F4(2), E2F5(5), E2F6(1), EP300(39), ESPL1(29), GSK3B(9), HDAC1(10), HDAC2(6), HDAC3(10), HDAC4(41), HDAC5(15), HDAC6(12), HDAC8(3), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(15), MCM3(8), MCM4(17), MCM5(11), MCM6(13), MCM7(8), MDM2(10), MPEG1(12), MPL(7), PCNA(2), PLK1(18), PRKDC(70), PTPRA(19), PTTG1(2), RB1(22), RBL1(14), SKP2(6), SMAD4(45), TBC1D8(16), TFDP1(6), TGFB1(3), TP53(374), WEE1(7) 94967661 1318 495 1048 220 323 158 151 288 385 13 <1.00e-15 1.000 1.000 135 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(4), IFNG(3), IFNGR1(11), JAK1(22), JAK2(14), PLA2G2A(2), PTPRU(33), REG1A(5), STAT1(14) 9878865 108 79 104 26 30 17 10 17 31 3 0.0916 1.000 1.000 136 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(8), ASPH(10), COPS5(6), CREB1(4), EDN1(4), EP300(39), EPO(3), HIF1A(10), JUN(6), LDHA(7), NOS3(20), P4HB(5), VHL(2) 14641881 124 89 116 23 25 21 17 28 33 0 0.00836 1.000 1.000 137 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(13), ACO1(9), ACO2(12), ACSS1(18), ACSS2(20), FH(4), IDH1(5), IDH2(8), MDH1(5), MDH2(2), SUCLA2(3) 11447763 99 68 97 19 23 25 7 21 23 0 0.00846 1.000 1.000 138 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(14), CD44(8), CSF1(6), FCGR3A(6), IL1B(7), IL6R(4), SELL(7), SPN(5), TGFB1(3), TGFB2(10), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TNFRSF8(12), TNFSF8(4) 11518027 99 73 95 28 25 10 9 26 28 1 0.189 1.000 1.000 139 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(36), CPT1A(16), LEP(3), LEPR(18), PRKAA1(9), PRKAA2(11), PRKAB1(13), PRKAB2(6), PRKAG1(6), PRKAG2(8) 12465450 126 87 121 28 33 17 13 32 30 1 0.0880 1.000 1.000 140 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), IGF1(3), IGF1R(24), IRS1(33), JUN(6), MAP2K1(9), MAPK3(3), MAPK8(7), PIK3CA(101), PIK3R1(17), PTPN11(10), RAF1(11), RASA1(28), SHC1(7), SOS1(12), SRF(5) 21363258 296 166 224 55 57 60 52 61 63 3 2.49e-06 1.000 1.000 141 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(15), PARK2(16), SNCA(1), SNCAIP(20), UBE2E2(1), UBE2F(4), UBE2G2(3), UBE2L3(1), UBE2L6(2) 5472712 63 53 61 22 18 10 8 16 11 0 0.384 1.000 1.000 142 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11) 4856023 34 29 33 12 6 2 6 13 7 0 0.619 1.000 1.000 143 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B1(25), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), FDXR(12), SHMT1(4) 13789904 148 93 131 29 34 19 21 30 43 1 0.0169 1.000 1.000 144 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(5), CD34(6), CD3E(3), CD4(11), CD58(8), CD8A(4), CSF3(3), IL3(3), IL6(1), KITLG(6) 5353744 50 42 44 17 6 7 8 10 19 0 0.668 1.000 1.000 145 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(8), GAD1(11), HDC(13), PNMT(11), TH(10), TPH1(6) 5185045 59 50 58 20 20 8 4 13 14 0 0.480 1.000 1.000 146 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(18), PDXK(4), PDXP(5), PNPO(4), PSAT1(10) 4151450 41 35 41 15 5 7 6 14 7 2 0.606 1.000 1.000 147 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(9), CYSLTR2(1), GPR161(18), GPR171(2), GPR18(4), GPR34(1), GPR39(11), GPR45(18), GPR65(1), GPR68(5), GPR75(6) 8330801 76 60 68 22 31 5 12 12 16 0 0.229 1.000 1.000 148 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(7), BCL2(4), BCR(18), CRKL(2), FOS(2), GRB2(4), HRAS(2), JAK2(14), JUN(6), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK3(3), MAPK8(7), MYC(6), PIK3CA(101), PIK3R1(17), RAF1(11), SOS1(12), STAT1(14), STAT5A(13), STAT5B(15) 24200315 303 174 233 56 59 64 49 61 67 3 4.40e-07 1.000 1.000 149 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(6), ANKRD1(6), ATF3(2), CYR61(2), DUSP14(3), EIF4E(2), EIF4EBP1(5), HBEGF(2), IFNG(3), IFRD1(10), IL18(1), IL1A(2), IL1R1(5), JUND(2), MYOG(4), NR4A3(8), WDR1(5) 9210517 68 50 62 16 23 6 5 12 22 0 0.123 1.000 1.000 150 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(9), IFNB1(4), JAK1(22), PTPRU(33), REG1A(5), STAT1(14), STAT2(10), TYK2(15) 10790986 112 80 108 25 37 12 10 18 33 2 0.0458 1.000 1.000 151 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(5), ALAS2(16), CPOX(5), FECH(8), HMBS(4), PPOX(10), UROD(3), UROS(6) 6465947 62 54 61 14 15 13 4 16 14 0 0.151 1.000 1.000 152 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(3), CALM3(2), CCL2(1), CCR5(5), CXCR4(1), FOS(2), GNAQ(4), JUN(6), MAPK14(3), MAPK8(7), PLCG1(27), PRKCA(9), PTK2B(20), SYT1(8) 11859953 100 80 95 23 35 13 10 19 23 0 0.0225 1.000 1.000 153 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(10), GABRA1(28), GABRA2(18), GABRA3(12), GABRA4(12), GABRA5(12), GABRA6(18), GPHN(16), NSF(2), SRC(5), UBQLN1(7) 10363622 140 97 136 35 29 13 30 50 18 0 0.0680 1.000 1.000 154 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(3), GORASP1(5), MAP2K4(12), MAP2K7(38), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), MAPKAPK5(6), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PIK3CA(101), PIK3CD(20), PIK3R1(17), SYT1(8), TRAF2(5), TRAF3(8), TRAF5(7), TRAF6(7) 29100027 340 192 275 58 95 63 48 61 67 6 1.47e-09 1.000 1.000 155 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(3), IFNGR1(11), IFNGR2(2), JAK1(22), JAK2(14), STAT1(14) 7075360 66 50 63 20 11 11 8 13 20 3 0.661 1.000 1.000 156 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(6), CYP2A13(15), CYP2A6(8), CYP2A7(9), NAT1(2), NAT2(6), XDH(32) 6915994 78 68 76 23 16 13 12 27 10 0 0.264 1.000 1.000 157 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(10), CHPT1(4), HEMK1(2), LCMT1(2), LCMT2(11), METTL2B(1), METTL6(5), PCYT1A(11), PCYT1B(9), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), WBSCR22(5) 12080911 107 71 101 21 23 19 14 23 27 1 0.0114 1.000 1.000 158 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(8), ACADM(7), ACADS(6), ACADVL(5), ACSL1(6), ACSL3(10), ACSL4(7), CPT1A(16), CPT2(8), EHHADH(5), HADHA(7), PECR(1), SCP2(6), SLC25A20(4) 14452312 96 70 93 18 22 10 13 22 29 0 0.0120 1.000 1.000 159 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(2), CASP7(5), DFFA(5), DFFB(5), ENDOG(2), GZMB(2), HMGB1(4), HMGB2(4), TOP2A(22), TOP2B(19) 8217118 70 55 60 16 10 11 8 24 17 0 0.427 1.000 1.000 160 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(9), ACP2(6), ACP5(4), ACPP(8), ACPT(6), ENPP1(12), ENPP3(16), FLAD1(6), RFK(3), TYR(18) 8387985 88 69 80 21 12 15 15 24 22 0 0.167 1.000 1.000 161 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF3(3), EPO(3), FLT3(21), IGF1(3), IL11(3), IL1A(2), IL3(3), IL6(1), KITLG(6), TGFB1(3), TGFB2(10), TGFB3(11) 7186976 70 56 67 22 17 10 8 17 18 0 0.419 1.000 1.000 162 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(6), EGF(15), EGFR(24), ELK1(6), FOS(2), GRB2(4), HRAS(2), JAK1(22), JUN(6), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK3(3), MAPK8(7), PIK3CA(101), PIK3R1(17), PLCG1(27), PRKCA(9), RAF1(11), RASA1(28), SHC1(7), SOS1(12), SRF(5), STAT1(14), STAT3(9), STAT5A(13) 32295914 395 201 318 68 84 77 58 80 91 5 1.12e-08 1.000 1.000 163 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(9), IFNAR2(4), IFNB1(4), JAK1(22), STAT1(14), STAT2(10), TYK2(15) 9381526 79 58 76 19 20 8 11 16 22 2 0.213 1.000 1.000 164 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(8), ARG1(3), GLS(13), GLUD1(5), OAT(6), PRODH(1) 4849047 36 30 35 12 7 4 5 12 8 0 0.507 1.000 1.000 165 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(7), CREB1(4), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K6(1), MAP3K1(24), MAPK1(4), MAPK14(3), MAPK3(3), NFKB1(10), PIK3CA(101), PIK3R1(17), RB1(22), RELA(7), SP1(6) 16795463 235 155 168 45 37 53 51 39 54 1 3.29e-05 1.000 1.000 166 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(7), BLVRB(1), HMOX1(8), IL10(4), IL10RA(8), IL10RB(3), IL1A(2), IL6(1), JAK1(22), STAT1(14), STAT3(9), STAT5A(13), TNF(3) 10508719 95 71 90 25 18 10 9 28 28 2 0.294 1.000 1.000 167 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(68), AXIN1(17), BTRC(12), CCND1(3), CREBBP(59), CSNK1A1(7), CSNK1D(5), CSNK2A1(6), CTBP1(5), CTNNB1(36), DVL1(8), FZD1(15), GSK3B(9), HDAC1(10), MAP3K7(14), MYC(6), NLK(19), PPARD(8), PPP2CA(5), TLE1(15), WIF1(5), WNT1(11) 25200816 343 182 301 74 82 42 33 59 121 6 0.00240 1.000 1.000 168 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(4), MTMR1(8), MTMR2(10), MTMR6(14), NFS1(1), PHPT1(2), THTPA(3), TPK1(5) 5500822 47 38 45 14 8 7 8 7 17 0 0.419 1.000 1.000 169 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(5), LDLR(15), NR0B2(4), NR1H3(5), NR1H4(8), RXRA(13) 4684048 50 39 49 17 22 4 4 8 12 0 0.344 1.000 1.000 170 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(12), APC(68), AXIN1(17), BTRC(12), CTNNB1(36), DLL1(17), DVL1(8), FZD1(15), GSK3B(9), NOTCH1(51), PSEN1(7), WNT1(11) 18454369 263 170 237 66 57 25 24 53 96 8 0.0690 1.000 1.000 171 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(26), ARHGEF1(15), F2(15), F2R(10), F2RL3(6), GNA12(2), GNA13(10), GNAI1(4), GNAQ(4), GNB1(2), GNGT1(4), MAP3K7(14), PIK3CA(101), PIK3R1(17), PLCB1(24), PPP1R12B(17), PRKCA(9), PTK2B(20), ROCK1(22) 22274356 322 186 256 61 72 61 56 68 61 4 1.42e-06 1.000 1.000 172 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), ECHS1(3), EHHADH(5), HADHA(7), SDS(5) 10410673 105 67 93 29 25 12 10 23 35 0 0.255 1.000 1.000 173 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(5), ALAS1(5), ALAS2(16), CPO(8), FECH(8), GATA1(4), HBA2(1), HBB(4), HMBS(4), UROD(3), UROS(6) 6809095 64 55 63 18 15 14 8 14 13 0 0.243 1.000 1.000 174 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(8), GNAQ(4), GNB1(2), GNGT1(4), HTR2C(11), PLCB1(24), TUB(10) 6145324 63 50 61 18 16 8 7 17 15 0 0.382 1.000 1.000 175 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(15), MBTPS1(16), MBTPS2(12), SCAP(18), SREBF1(18), SREBF2(17) 10175612 98 68 95 25 29 8 11 23 27 0 0.110 1.000 1.000 176 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(59), EP300(39), LPL(11), NCOA1(27), NCOA2(33), PPARG(6), RXRA(13) 15810987 188 113 178 39 50 26 23 46 43 0 0.00225 1.000 1.000 177 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(2), BET1L(1), BNIP1(8), GOSR1(3), GOSR2(4), SNAP25(3), SNAP29(2), STX10(5), STX11(8), STX12(4), STX16(13), STX17(4), STX18(3), STX19(6), STX2(7), STX3(2), STX4(4), STX5(2), STX6(8), STX7(4), STX8(4), TSNARE1(8), USE1(5), VAMP1(1), VAMP2(1), VAMP4(3), VAMP5(2), VAMP7(2), VAMP8(1), VTI1A(6), VTI1B(3), YKT6(5) 14474448 134 92 130 26 39 22 16 28 29 0 0.00576 1.000 1.000 178 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(5), BRAF(22), CAMP(3), CREB1(4), CREB5(9), MAPK1(4), RAF1(11), SNX13(13), SRC(5), TERF2IP(6) 9749378 86 66 79 21 19 14 9 22 22 0 0.196 1.000 1.000 179 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(6), ECHS1(3), EHHADH(5), HADH(3), HADHA(7), HSD17B4(11), NTAN1(7), SIRT1(13), SIRT2(4), SIRT5(5), SIRT7(6), VNN2(4) 10221351 74 51 69 18 17 13 9 14 21 0 0.113 1.000 1.000 180 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), ESCO1(13), ESCO2(11), NAT6(4), PNPLA3(4), SH3GLB1(5) 14014545 60 49 58 9 14 4 6 11 25 0 0.0736 1.000 1.000 181 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(17), ACVR1C(7), AKT1(7), AKT2(11), AKT3(10), ARRB1(8), ARRB2(3), ATF2(4), ATF4(4), BDNF(12), BRAF(22), CACNA1A(47), CACNA1B(38), CACNA1C(58), CACNA1D(50), CACNA1E(68), CACNA1F(21), CACNA1G(34), CACNA1H(50), CACNA1I(34), CACNA1S(31), CACNA2D1(24), CACNA2D2(9), CACNA2D3(30), CACNA2D4(18), CACNB1(6), CACNB2(20), CACNB3(4), CACNB4(7), CACNG1(5), CACNG2(4), CACNG3(7), CACNG4(4), CACNG5(13), CACNG6(5), CACNG7(11), CACNG8(6), CASP3(2), CD14(2), CDC25B(8), CDC42(3), CHUK(10), CRK(2), CRKL(2), DAXX(14), DDIT3(5), DUSP1(3), DUSP10(11), DUSP14(3), DUSP16(12), DUSP2(1), DUSP3(1), DUSP4(3), DUSP5(10), DUSP6(5), DUSP7(3), DUSP8(2), DUSP9(10), ECSIT(8), EGF(15), EGFR(24), ELK1(6), ELK4(2), FAS(3), FASLG(6), FGF1(5), FGF10(5), FGF11(1), FGF12(9), FGF13(19), FGF14(12), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(7), FGF3(3), FGF4(1), FGF5(8), FGF6(8), FGF7(7), FGF8(2), FGF9(11), FGFR1(19), FGFR2(14), FGFR3(10), FGFR4(22), FLNA(31), FLNB(37), FLNC(48), FOS(2), GADD45B(3), GNA12(2), GNG12(12), GRB2(4), HRAS(2), IKBKB(12), IL1A(2), IL1B(7), IL1R1(5), IL1R2(13), JUN(6), JUND(2), KRAS(40), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K5(3), MAP2K6(1), MAP2K7(38), MAP3K1(24), MAP3K10(17), MAP3K12(17), MAP3K13(14), MAP3K2(9), MAP3K3(10), MAP3K4(32), MAP3K5(18), MAP3K6(14), MAP3K7(14), MAP3K8(2), MAP4K1(4), MAP4K2(14), MAP4K3(8), MAP4K4(16), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK7(9), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), MAPKAPK2(4), MAPKAPK3(5), MAPKAPK5(6), MAPT(12), MAX(4), MEF2C(7), MKNK1(6), MKNK2(10), MOS(11), MRAS(5), MYC(6), NF1(40), NFATC2(32), NFATC4(20), NFKB1(10), NFKB2(11), NLK(19), NR4A1(6), NRAS(5), NTF3(5), NTRK1(14), NTRK2(22), PAK1(7), PAK2(13), PDGFA(4), PDGFB(8), PDGFRA(17), PDGFRB(16), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PPM1A(5), PPM1B(14), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PPP5C(11), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), PTPN5(9), PTPN7(8), PTPRR(16), RAC1(2), RAC2(2), RAC3(4), RAF1(11), RAP1A(4), RAP1B(6), RAPGEF2(20), RASA1(28), RASA2(12), RASGRF1(24), RASGRF2(20), RASGRP1(11), RASGRP2(9), RASGRP3(8), RASGRP4(8), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA4(13), RPS6KA5(9), RPS6KA6(24), RRAS(1), RRAS2(3), SOS1(12), SOS2(19), SRF(5), STK3(5), STK4(5), STMN1(3), TAOK1(14), TAOK2(23), TAOK3(14), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TGFBR2(32), TNF(3), TNFRSF1A(6), TP53(374), TRAF2(5), TRAF6(7), ZAK(12) 248438407 3026 528 2653 747 925 382 328 625 742 24 <1.00e-15 1.000 1.000 182 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(10), ACTG1(2), ACTN1(8), ACTN2(34), ACTN4(20), AKT1(7), AKT2(11), AKT3(10), ARHGAP5(34), BAD(4), BCAR1(16), BCL2(4), BIRC2(8), BIRC3(12), BRAF(22), CAPN2(11), CAV1(6), CAV2(1), CAV3(2), CCND1(3), CCND2(2), CCND3(1), CDC42(3), CHAD(7), COL11A1(67), COL11A2(26), COL1A1(21), COL1A2(39), COL2A1(26), COL3A1(23), COL4A1(35), COL4A2(24), COL4A4(25), COL4A6(15), COL5A1(39), COL5A2(25), COL5A3(22), COL6A1(19), COL6A2(33), COL6A3(67), COL6A6(53), COMP(8), CRK(2), CRKL(2), CTNNB1(36), DIAPH1(16), DOCK1(29), EGF(15), EGFR(24), ELK1(6), ERBB2(35), FARP2(9), FIGF(5), FLNA(31), FLNB(37), FLNC(48), FLT1(26), FN1(40), FYN(10), GRB2(4), GSK3B(9), HGF(22), HRAS(2), IBSP(9), IGF1(3), IGF1R(24), ILK(11), ITGA1(10), ITGA10(19), ITGA11(18), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGAV(23), ITGB1(12), ITGB3(8), ITGB4(29), ITGB5(10), ITGB6(9), ITGB7(7), ITGB8(18), JUN(6), KDR(22), LAMA1(85), LAMA2(51), LAMA3(37), LAMA4(33), LAMA5(58), LAMB1(22), LAMB2(30), LAMB3(22), LAMB4(33), LAMC1(29), LAMC2(14), LAMC3(25), MAP2K1(9), MAPK1(4), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(7), MET(14), MYL2(9), MYL7(5), MYL9(3), MYLK(31), MYLK2(9), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PARVA(4), PARVB(6), PARVG(6), PDGFA(4), PDGFB(8), PDGFC(11), PDGFD(11), PDGFRA(17), PDGFRB(16), PDPK1(1), PGF(4), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PIP5K1C(15), PPP1CA(3), PPP1CB(1), PPP1CC(4), PPP1R12A(4), PRKCA(9), PRKCG(19), PTEN(43), PTK2(12), PXN(9), RAC1(2), RAC2(2), RAC3(4), RAF1(11), RAP1A(4), RAP1B(6), RAPGEF1(15), RELN(69), RHOA(23), ROCK1(22), ROCK2(20), SHC1(7), SHC2(3), SHC3(12), SHC4(11), SOS1(12), SOS2(19), SPP1(4), SRC(5), THBS1(19), THBS2(24), THBS3(13), THBS4(18), TLN1(35), TLN2(43), TNC(35), TNN(38), TNR(36), TNXB(82), VASP(2), VAV1(21), VAV2(14), VAV3(16), VCL(19), VEGFB(2), VEGFC(17), VTN(10), VWF(47), ZYX(8) 320894828 3395 509 3185 1033 994 497 376 813 686 29 1.40e-06 1.000 1.000 183 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(68), APC2(19), AXIN1(17), AXIN2(22), BTRC(12), CACYBP(4), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CCND1(3), CCND2(2), CCND3(1), CER1(4), CHD8(36), CREBBP(59), CSNK1A1(7), CSNK1A1L(8), CSNK1E(10), CSNK2A1(6), CSNK2A2(9), CTBP1(5), CTBP2(10), CTNNB1(36), CTNNBIP1(3), CUL1(28), CXXC4(5), DAAM1(21), DAAM2(22), DKK1(12), DKK2(11), DKK4(7), DVL1(8), DVL2(11), DVL3(17), EP300(39), FBXW11(9), FOSL1(3), FZD1(15), FZD10(22), FZD2(17), FZD3(13), FZD4(9), FZD5(6), FZD6(13), FZD7(15), FZD8(14), FZD9(5), GSK3B(9), JUN(6), LEF1(5), LRP5(35), LRP6(16), MAP3K7(14), MAPK10(7), MAPK8(7), MAPK9(7), MMP7(2), MYC(6), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NKD1(8), NKD2(7), NLK(19), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PORCN(6), PPARD(8), PPP2CA(5), PPP2CB(4), PPP2R1A(18), PPP2R1B(10), PPP2R2A(10), PPP2R2B(9), PPP2R2C(7), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRICKLE1(24), PRICKLE2(22), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), PSEN1(7), RAC1(2), RAC2(2), RAC3(4), RBX1(1), RHOA(23), ROCK1(22), ROCK2(20), RUVBL1(9), SENP2(10), SFRP1(9), SFRP2(7), SFRP4(8), SFRP5(1), SIAH1(3), SMAD2(11), SMAD3(9), SMAD4(45), SOX17(16), TBL1X(10), TBL1XR1(11), TBL1Y(2), TCF7(9), TCF7L1(10), TCF7L2(12), TP53(374), VANGL1(8), VANGL2(14), WIF1(5), WNT1(11), WNT10A(6), WNT10B(3), WNT11(3), WNT16(16), WNT2(6), WNT2B(14), WNT3(6), WNT3A(9), WNT4(2), WNT5A(8), WNT5B(6), WNT6(4), WNT7A(6), WNT7B(10), WNT8A(2), WNT8B(2), WNT9A(9), WNT9B(6) 138546613 2018 505 1705 409 613 249 203 407 528 18 <1.00e-15 1.000 1.000 184 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(12), ANAPC1(22), ANAPC10(2), ANAPC11(1), ANAPC2(9), ANAPC4(4), ANAPC5(8), ANAPC7(7), ATM(71), ATR(33), BUB1(15), BUB1B(16), BUB3(4), CCNA1(13), CCNA2(2), CCNB1(4), CCNB2(1), CCNB3(24), CCND1(3), CCND2(2), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDC14A(21), CDC14B(8), CDC16(7), CDC20(10), CDC23(7), CDC25A(8), CDC25B(8), CDC25C(11), CDC26(3), CDC27(12), CDC6(13), CDC7(8), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN1B(1), CDKN2A(36), CDKN2B(1), CDKN2C(2), CDKN2D(5), CHEK1(7), CHEK2(13), CREBBP(59), CUL1(28), DBF4(10), E2F1(6), E2F2(7), E2F3(4), EP300(39), ESPL1(29), FZR1(12), GADD45B(3), GSK3B(9), HDAC1(10), HDAC2(6), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(15), MCM3(8), MCM4(17), MCM5(11), MCM6(13), MCM7(8), MDM2(10), PCNA(2), PKMYT1(8), PLK1(18), PRKDC(70), PTTG1(2), RB1(22), RBL1(14), RBL2(11), RBX1(1), SFN(1), SKP2(6), SMAD2(11), SMAD3(9), SMAD4(45), SMC1A(7), SMC1B(13), TFDP1(6), TGFB1(3), TGFB2(10), TGFB3(11), TP53(374), WEE1(7), YWHAB(3), YWHAE(5), YWHAG(4), YWHAH(3), YWHAQ(5), YWHAZ(4) 117223906 1461 491 1191 261 344 169 167 326 442 13 <1.00e-15 1.000 1.000 185 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY7(23), ADCY8(48), ADCY9(23), ADORA2A(7), ADORA2B(4), ADRA1A(26), ADRA1B(6), ADRA1D(9), ADRB1(10), ADRB2(9), ADRB3(6), AGTR1(1), ATP2A1(16), ATP2A2(9), ATP2A3(14), ATP2B1(21), ATP2B2(27), ATP2B3(26), ATP2B4(23), AVPR1A(20), AVPR1B(3), BDKRB1(4), BDKRB2(3), BST1(4), CACNA1A(47), CACNA1B(38), CACNA1C(58), CACNA1D(50), CACNA1E(68), CACNA1F(21), CACNA1G(34), CACNA1H(50), CACNA1I(34), CACNA1S(31), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), CCKAR(8), CCKBR(19), CD38(7), CHRM1(8), CHRM2(27), CHRM3(17), CHRM5(5), CHRNA7(7), CYSLTR1(9), CYSLTR2(1), DRD1(7), EDNRA(5), EDNRB(36), EGFR(24), ERBB2(35), ERBB3(49), ERBB4(76), F2R(10), GNA11(6), GNA14(6), GNA15(6), GNAL(5), GNAQ(4), GNAS(54), GRIN1(11), GRIN2A(23), GRIN2C(13), GRIN2D(12), GRM1(52), GRM5(42), GRPR(7), HRH1(7), HRH2(9), HTR2A(12), HTR2B(5), HTR2C(11), HTR4(5), HTR5A(14), HTR6(7), HTR7(17), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), LHCGR(24), LTB4R2(6), MYLK(31), MYLK2(9), NOS1(45), NOS3(20), NTSR1(11), OXTR(9), P2RX1(5), P2RX2(8), P2RX3(7), P2RX4(9), P2RX5(7), P2RX7(4), PDE1A(10), PDE1B(8), PDE1C(17), PDGFRA(17), PDGFRB(16), PHKA1(15), PHKA2(18), PHKB(11), PHKG1(4), PHKG2(13), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCD3(11), PLCD4(8), PLCE1(27), PLCG1(27), PLCG2(22), PLCZ1(14), PPID(6), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), PTAFR(4), PTGER3(9), PTGFR(6), PTK2B(20), RYR1(81), RYR2(141), RYR3(109), SLC25A4(5), SLC25A5(5), SLC25A6(5), SLC8A1(26), SLC8A2(22), SLC8A3(13), SPHK1(10), SPHK2(11), TACR1(4), TACR2(2), TACR3(18), TBXA2R(11), TNNC1(3), TNNC2(1), TRHR(7), TRPC1(16), VDAC1(5), VDAC2(3), VDAC3(7) 233909003 2888 485 2730 883 971 352 339 713 502 11 2.27e-07 1.000 1.000 186 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(10), ADORA1(7), ADORA2A(7), ADORA2B(4), ADORA3(9), ADRA1A(26), ADRA1B(6), ADRA2A(12), ADRA2B(11), ADRA2C(6), ADRB1(10), ADRB2(9), ADRB3(6), AGTR1(1), AGTR2(6), AVPR1A(20), AVPR1B(3), AVPR2(12), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(13), C5AR1(7), CALCR(6), CALCRL(11), CCKAR(8), CCKBR(19), CGA(1), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), CNR1(16), CNR2(4), CRHR1(14), CRHR2(4), CTSG(4), CYSLTR1(9), CYSLTR2(1), DRD1(7), DRD2(14), DRD3(9), DRD4(6), DRD5(13), EDNRA(5), EDNRB(36), F2(15), F2R(10), F2RL1(2), F2RL2(5), F2RL3(6), FPR1(9), FSHB(1), FSHR(30), GABBR1(20), GABBR2(18), GABRA1(28), GABRA2(18), GABRA3(12), GABRA4(12), GABRA5(12), GABRA6(18), GABRB1(17), GABRB2(7), GABRB3(17), GABRD(8), GABRE(10), GABRG1(16), GABRG2(20), GABRG3(11), GABRP(7), GABRQ(12), GABRR1(7), GABRR2(8), GALR1(8), GALR2(14), GALR3(5), GH1(3), GH2(4), GHR(11), GHRHR(6), GHSR(10), GIPR(7), GLP1R(2), GLP2R(12), GLRA1(8), GLRA2(6), GLRA3(8), GLRB(16), GNRHR(5), GPR156(12), GPR35(5), GPR50(12), GPR63(6), GPR83(9), GRIA1(31), GRIA2(34), GRIA3(16), GRIA4(23), GRID1(30), GRID2(30), GRIK1(16), GRIK2(21), GRIK3(26), GRIK4(24), GRIK5(20), GRIN1(11), GRIN2A(23), GRIN2B(31), GRIN2C(13), GRIN2D(12), GRIN3A(24), GRIN3B(10), GRM1(52), GRM2(30), GRM3(31), GRM4(22), GRM5(42), GRM6(21), GRM7(30), GRM8(38), GRPR(7), GZMA(5), HCRTR1(6), HCRTR2(14), HRH1(7), HRH2(9), HRH3(8), HRH4(10), HTR1A(18), HTR1B(11), HTR1D(9), HTR1E(18), HTR1F(10), HTR2A(12), HTR2B(5), HTR2C(11), HTR4(5), HTR5A(14), HTR6(7), HTR7(17), LEP(3), LEPR(18), LHB(3), LHCGR(24), LTB4R(2), LTB4R2(6), MAS1(4), MC1R(8), MC2R(4), MC3R(12), MC4R(11), MC5R(6), MCHR1(10), MCHR2(9), MLNR(5), MTNR1A(5), MTNR1B(10), NMBR(3), NMUR1(7), NMUR2(7), NPBWR1(25), NPBWR2(14), NPFFR1(3), NPFFR2(14), NPY1R(6), NPY2R(8), NPY5R(5), NR3C1(10), NTSR1(11), NTSR2(7), OPRD1(5), OPRK1(19), OPRL1(11), OPRM1(9), OXTR(9), P2RX1(5), P2RX2(8), P2RX3(7), P2RX4(9), P2RX5(7), P2RX7(4), P2RY1(5), P2RY10(14), P2RY11(5), P2RY13(7), P2RY14(6), P2RY2(5), P2RY4(14), P2RY6(12), P2RY8(9), PARD3(24), PRL(3), PRLHR(10), PRLR(8), PRSS1(6), PRSS3(4), PTAFR(4), PTGDR(8), PTGER2(8), PTGER3(9), PTGER4(15), PTGFR(6), PTGIR(2), PTH2R(13), RXFP1(14), RXFP2(18), SCTR(5), SSTR1(12), SSTR2(4), SSTR3(11), SSTR4(18), SSTR5(4), TAAR1(6), TAAR2(5), TAAR5(7), TAAR6(9), TAAR8(1), TACR1(4), TACR2(2), TACR3(18), TBXA2R(11), THRA(13), THRB(5), TRHR(7), TRPV1(11), TSHB(5), TSHR(15), TSPO(2), UTS2R(4), VIPR1(3), VIPR2(5) 189810269 2604 485 2492 854 853 315 323 729 380 4 4.12e-05 1.000 1.000 187 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(10), ACTN1(8), ACTN2(34), ACTN4(20), APC(68), APC2(19), ARAF(16), ARHGEF1(15), ARHGEF12(18), ARHGEF4(15), ARHGEF6(13), ARHGEF7(13), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), ARPC5(1), ARPC5L(3), BAIAP2(7), BCAR1(16), BDKRB1(4), BDKRB2(3), BRAF(22), CD14(2), CDC42(3), CFL1(2), CFL2(1), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), CRK(2), CRKL(2), CSK(10), CYFIP1(19), CYFIP2(29), DIAPH1(16), DIAPH2(18), DIAPH3(24), DOCK1(29), EGF(15), EGFR(24), EZR(6), F2(15), F2R(10), FGD1(16), FGD3(19), FGF1(5), FGF10(5), FGF11(1), FGF12(9), FGF13(19), FGF14(12), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(7), FGF3(3), FGF4(1), FGF5(8), FGF6(8), FGF7(7), FGF8(2), FGF9(11), FGFR1(19), FGFR2(14), FGFR3(10), FGFR4(22), FN1(40), GIT1(4), GNA12(2), GNA13(10), GNG12(12), GSN(15), HRAS(2), IQGAP1(22), IQGAP2(15), IQGAP3(24), ITGA1(10), ITGA10(19), ITGA11(18), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGAD(23), ITGAE(19), ITGAL(28), ITGAM(13), ITGAV(23), ITGAX(15), ITGB1(12), ITGB2(12), ITGB3(8), ITGB4(29), ITGB5(10), ITGB6(9), ITGB7(7), ITGB8(18), KRAS(40), LIMK1(7), LIMK2(6), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MOS(11), MRAS(5), MSN(18), MYH10(45), MYH14(34), MYH9(44), MYL2(9), MYL7(5), MYL9(3), MYLK(31), MYLK2(9), NCKAP1(17), NCKAP1L(17), NRAS(5), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PDGFA(4), PDGFB(8), PDGFRA(17), PDGFRB(16), PFN1(1), PFN2(1), PFN3(3), PFN4(2), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PIP4K2A(9), PIP4K2B(9), PIP4K2C(2), PIP5K1A(4), PIP5K1B(2), PIP5K1C(15), PPP1CA(3), PPP1CB(1), PPP1CC(4), PPP1R12A(4), PPP1R12B(17), PTK2(12), PXN(9), RAC1(2), RAC2(2), RAC3(4), RAF1(11), RDX(13), RHOA(23), ROCK1(22), ROCK2(20), RRAS(1), RRAS2(3), SCIN(14), SLC9A1(14), SOS1(12), SOS2(19), SSH1(14), SSH2(29), SSH3(12), TIAM1(44), TIAM2(29), VAV1(21), VAV2(14), VAV3(16), VCL(19), WAS(4), WASF1(11), WASF2(10), WASL(7) 238947895 2549 474 2340 706 759 370 316 556 533 15 4.83e-09 1.000 1.000 188 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(10), ACTG1(2), CHAD(7), COL11A1(67), COL11A2(26), COL17A1(16), COL1A1(21), COL1A2(39), COL2A1(26), COL3A1(23), COL4A1(35), COL4A2(24), COL4A4(25), COL4A6(15), COL5A1(39), COL5A2(25), COL5A3(22), COL6A1(19), COL6A2(33), COL6A3(67), COL6A6(53), COMP(8), DES(3), DSC1(3), DSC2(14), DSC3(8), DSG1(12), DSG2(12), DSG3(19), DSG4(10), FN1(40), GJA1(14), GJA10(6), GJA3(4), GJA4(8), GJA5(10), GJA8(10), GJA9(2), GJB1(2), GJB3(4), GJB4(5), GJB5(3), GJB6(7), GJB7(4), GJC1(6), GJC2(4), GJC3(1), GJD2(9), GJD4(4), IBSP(9), INA(7), ITGA6(17), ITGB4(29), KRT1(12), KRT10(9), KRT12(10), KRT13(11), KRT14(4), KRT15(6), KRT16(11), KRT17(8), KRT18(5), KRT19(6), KRT2(13), KRT20(6), KRT23(17), KRT24(10), KRT25(11), KRT27(14), KRT28(12), KRT3(11), KRT31(8), KRT32(6), KRT33A(12), KRT33B(10), KRT34(10), KRT35(8), KRT36(7), KRT37(4), KRT38(5), KRT39(9), KRT4(7), KRT40(3), KRT5(7), KRT6A(17), KRT6B(11), KRT6C(13), KRT7(5), KRT71(3), KRT72(17), KRT73(19), KRT74(8), KRT75(40), KRT76(6), KRT77(4), KRT78(5), KRT79(10), KRT8(10), KRT81(7), KRT82(6), KRT83(4), KRT84(9), KRT85(7), KRT86(4), KRT9(6), LAMA1(85), LAMA2(51), LAMA3(37), LAMA4(33), LAMA5(58), LAMB1(22), LAMB2(30), LAMB3(22), LAMB4(33), LAMC1(29), LAMC2(14), LAMC3(25), LMNA(13), LMNB1(5), LMNB2(11), NES(25), PRPH(7), RELN(69), SPP1(4), THBS1(19), THBS2(24), THBS3(13), THBS4(18), TNC(35), TNN(38), TNR(36), TNXB(82), VIM(12), VTN(10), VWF(47) 215449998 2278 463 2188 812 697 317 216 618 413 17 0.414 1.000 1.000 189 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(27), CD36(7), CD44(8), CD47(1), CHAD(7), COL11A1(67), COL11A2(26), COL1A1(21), COL1A2(39), COL2A1(26), COL3A1(23), COL4A1(35), COL4A2(24), COL4A4(25), COL4A6(15), COL5A1(39), COL5A2(25), COL5A3(22), COL6A1(19), COL6A2(33), COL6A3(67), COL6A6(53), DAG1(14), FN1(40), FNDC1(34), FNDC3A(14), FNDC4(6), FNDC5(3), GP5(15), GP6(5), GP9(3), HMMR(13), HSPG2(87), IBSP(9), ITGA1(10), ITGA10(19), ITGA11(18), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGAV(23), ITGB1(12), ITGB3(8), ITGB4(29), ITGB5(10), ITGB6(9), ITGB7(7), ITGB8(18), LAMA1(85), LAMA2(51), LAMA3(37), LAMA4(33), LAMA5(58), LAMB1(22), LAMB2(30), LAMB3(22), LAMB4(33), LAMC1(29), LAMC2(14), LAMC3(25), RELN(69), SDC1(2), SDC2(3), SDC3(5), SDC4(6), SPP1(4), SV2A(20), SV2B(7), SV2C(15), THBS1(19), THBS2(24), THBS3(13), THBS4(18), TNC(35), TNN(38), TNR(36), TNXB(82), VTN(10), VWF(47) 193883797 2057 443 1952 658 612 272 189 545 423 16 0.0138 1.000 1.000 190 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(12), ABLIM1(15), ABLIM2(14), ABLIM3(8), ARHGEF12(18), CDC42(3), CDK5(3), CFL1(2), CFL2(1), CXCR4(1), DCC(52), DPYSL2(5), DPYSL5(14), EFNA1(3), EFNA2(2), EFNA4(6), EFNA5(5), EFNB1(5), EFNB2(7), EFNB3(15), EPHA1(15), EPHA2(34), EPHA3(40), EPHA4(21), EPHA5(40), EPHA6(38), EPHA7(20), EPHA8(23), EPHB1(41), EPHB2(19), EPHB3(14), EPHB4(20), EPHB6(27), FES(14), FYN(10), GNAI1(4), GNAI2(5), GNAI3(9), GSK3B(9), HRAS(2), ITGB1(12), KRAS(40), L1CAM(22), LIMK1(7), LIMK2(6), LRRC4C(12), MAPK1(4), MAPK3(3), MET(14), NCK1(7), NCK2(10), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NGEF(8), NRAS(5), NRP1(17), NTN1(8), NTN4(6), NTNG1(25), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PLXNA1(45), PLXNA2(36), PLXNA3(26), PLXNB1(38), PLXNB2(35), PLXNB3(18), PLXNC1(21), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PTK2(12), RAC1(2), RAC2(2), RAC3(4), RASA1(28), RGS3(21), RHOA(23), RHOD(3), RND1(2), ROBO1(45), ROBO2(45), ROBO3(20), ROCK1(22), ROCK2(20), SEMA3A(22), SEMA3C(8), SEMA3D(22), SEMA3E(22), SEMA3F(14), SEMA3G(9), SEMA4A(12), SEMA4B(3), SEMA4C(14), SEMA4D(16), SEMA4F(12), SEMA4G(7), SEMA5A(37), SEMA5B(31), SEMA6A(21), SEMA6B(10), SEMA6C(13), SEMA6D(35), SEMA7A(9), SLIT1(15), SLIT2(49), SLIT3(31), SRGAP1(16), SRGAP3(16), UNC5A(16), UNC5B(14), UNC5C(27), UNC5D(34) 169261986 2004 439 1890 582 558 273 237 526 400 10 3.37e-05 1.000 1.000 191 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ADRA1A(26), ADRA1B(6), ADRA1D(9), ADRB1(10), ADRB2(9), ADRB3(6), ANXA6(4), ARRB1(8), ARRB2(3), ATP1A4(24), ATP1B1(8), ATP1B2(4), ATP1B3(4), ATP2A2(9), ATP2A3(14), ATP2B1(21), ATP2B2(27), ATP2B3(26), CACNA1A(47), CACNA1B(38), CACNA1C(58), CACNA1D(50), CACNA1E(68), CACNA1S(31), CACNB1(6), CACNB3(4), CALM1(2), CALM2(3), CALM3(2), CALR(4), CAMK1(4), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), CASQ1(9), CASQ2(4), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), GJA1(14), GJA4(8), GJA5(10), GJB1(2), GJB3(4), GJB4(5), GJB5(3), GJB6(7), GNA11(6), GNAI2(5), GNAI3(9), GNAO1(2), GNAQ(4), GNAZ(19), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(4), GNG12(12), GNG13(3), GNG2(2), GNG7(4), GNGT1(4), GRK4(13), GRK5(4), GRK6(5), ITPR1(40), ITPR2(41), ITPR3(46), KCNB1(17), KCNJ3(18), KCNJ5(8), MIB1(5), NME7(4), PEA15(1), PKIA(3), PKIG(1), PLCB3(21), PRKACA(9), PRKACB(6), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCQ(18), PRKCZ(4), PRKD1(30), RGS1(4), RGS10(5), RGS11(7), RGS14(5), RGS16(3), RGS17(5), RGS18(10), RGS19(5), RGS2(7), RGS20(9), RGS3(21), RGS4(8), RGS5(2), RGS6(17), RGS7(7), RGS9(13), RYR1(81), RYR2(141), RYR3(109), SFN(1), SLC8A1(26), SLC8A3(13), USP5(11), YWHAB(3), YWHAH(3), YWHAQ(5) 163134061 1918 427 1835 638 635 222 232 447 371 11 0.0143 1.000 1.000 192 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(10), ACTG1(2), ACTN1(8), ACTN2(34), ACTN4(20), AKT1(7), AKT2(11), AKT3(10), AMOTL1(14), ASH1L(45), CASK(10), CDC42(3), CDK4(2), CGN(19), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(7), CLDN17(8), CLDN18(4), CLDN19(7), CLDN2(2), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(10), CLDN7(1), CLDN8(3), CLDN9(9), CRB3(2), CSNK2A1(6), CSNK2A2(9), CTNNA1(24), CTNNA2(32), CTNNA3(29), CTNNB1(36), CTTN(13), EPB41(16), EPB41L1(14), EPB41L2(16), EPB41L3(49), EXOC3(6), EXOC4(16), F11R(2), GNAI1(4), GNAI2(5), GNAI3(9), HCLS1(4), HRAS(2), IGSF5(5), INADL(24), JAM2(2), JAM3(7), KRAS(40), LLGL1(14), LLGL2(12), MAGI1(30), MAGI2(36), MAGI3(14), MLLT4(32), MPDZ(35), MPP5(9), MRAS(5), MYH1(33), MYH10(45), MYH11(36), MYH13(39), MYH14(34), MYH15(21), MYH2(49), MYH3(41), MYH4(32), MYH6(34), MYH7(47), MYH7B(27), MYH8(23), MYH9(44), MYL2(9), MYL7(5), MYL9(3), NRAS(5), OCLN(10), PARD3(24), PARD6A(1), PARD6B(5), PARD6G(2), PPM1J(4), PPP2CA(5), PPP2CB(4), PPP2R1A(18), PPP2R1B(10), PPP2R2A(10), PPP2R2B(9), PPP2R2C(7), PPP2R3A(15), PPP2R3B(17), PPP2R4(5), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCI(8), PRKCQ(18), PRKCZ(4), PTEN(43), RAB13(3), RAB3B(5), RHOA(23), RRAS(1), RRAS2(3), SPTAN1(30), SRC(5), SYMPK(14), TJAP1(5), TJP1(32), TJP2(19), TJP3(13), VAPA(4), YES1(9), ZAK(12) 167894818 1829 427 1716 519 538 251 210 475 346 9 7.71e-05 1.000 1.000 193 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(14), CADM1(23), CADM3(14), CD2(5), CD22(10), CD226(3), CD274(4), CD276(8), CD28(2), CD34(6), CD4(11), CD40(3), CD40LG(6), CD58(8), CD6(13), CD80(6), CD86(8), CD8A(4), CD8B(2), CD99(1), CDH1(34), CDH15(11), CDH2(27), CDH3(14), CDH4(31), CDH5(15), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(7), CLDN17(8), CLDN18(4), CLDN19(7), CLDN2(2), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(10), CLDN7(1), CLDN8(3), CLDN9(9), CNTN1(34), CNTN2(15), CNTNAP1(23), CNTNAP2(47), CTLA4(4), ESAM(6), F11R(2), GLG1(21), HLA-A(23), HLA-B(36), HLA-C(11), HLA-DMA(1), HLA-DMB(7), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(3), HLA-DPB1(5), HLA-DQA2(7), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(2), HLA-DRB5(3), HLA-E(7), HLA-F(8), HLA-G(7), ICAM1(5), ICAM2(4), ICAM3(7), ICOS(4), ICOSLG(2), ITGA4(21), ITGA6(17), ITGA8(22), ITGA9(11), ITGAL(28), ITGAM(13), ITGAV(23), ITGB1(12), ITGB2(12), ITGB7(7), ITGB8(18), JAM2(2), JAM3(7), L1CAM(22), MADCAM1(4), MAG(24), MPZ(2), MPZL1(5), NCAM1(13), NCAM2(39), NEGR1(14), NEO1(22), NFASC(42), NLGN1(31), NLGN2(11), NLGN3(15), NRCAM(16), NRXN1(51), NRXN2(37), NRXN3(45), OCLN(10), PDCD1(6), PDCD1LG2(4), PTPRC(30), PTPRF(24), PTPRM(43), PVR(5), PVRL1(9), PVRL2(9), PVRL3(12), SDC1(2), SDC2(3), SDC3(5), SDC4(6), SELE(9), SELL(7), SELP(14), SELPLG(10), SIGLEC1(31), SPN(5), VCAM1(13), VCAN(59) 126887571 1577 411 1481 456 424 214 187 408 336 8 7.10e-06 1.000 1.000 194 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(6), ACVR1B(17), ACVR2A(11), ACVR2B(6), AMHR2(11), BMP2(8), BMP7(9), BMPR1A(13), BMPR1B(13), BMPR2(24), CCL1(3), CCL11(1), CCL13(1), CCL14(2), CCL15(2), CCL16(3), CCL18(4), CCL19(2), CCL2(1), CCL20(5), CCL22(3), CCL23(1), CCL24(2), CCL25(1), CCL27(2), CCL28(2), CCL3(1), CCL5(4), CCL7(2), CCL8(3), CCR1(8), CCR2(6), CCR3(14), CCR4(3), CCR5(5), CCR6(2), CCR7(5), CCR8(4), CCR9(8), CD27(2), CD40(3), CD40LG(6), CD70(3), CLCF1(4), CNTF(4), CNTFR(6), CRLF2(3), CSF1(6), CSF1R(26), CSF2RA(12), CSF2RB(18), CSF3(3), CSF3R(18), CX3CL1(10), CX3CR1(7), CXCL1(1), CXCL10(1), CXCL14(1), CXCL2(2), CXCL3(1), CXCL5(1), CXCL6(1), CXCL9(2), CXCR3(3), CXCR4(1), CXCR6(2), EDA(5), EDA2R(5), EDAR(9), EGF(15), EGFR(24), EPO(3), EPOR(5), FAS(3), FASLG(6), FLT1(26), FLT3(21), FLT3LG(2), FLT4(36), GDF5(15), GH1(3), GH2(4), GHR(11), HGF(22), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNAR1(9), IFNAR2(4), IFNB1(4), IFNG(3), IFNGR1(11), IFNGR2(2), IFNK(1), IFNW1(4), IL10(4), IL10RA(8), IL10RB(3), IL11(3), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL13(4), IL13RA1(6), IL15(2), IL15RA(6), IL17B(4), IL17RA(11), IL17RB(7), IL18(1), IL18R1(7), IL18RAP(4), IL19(2), IL1A(2), IL1B(7), IL1R1(5), IL1R2(13), IL1RAP(8), IL20(3), IL20RA(5), IL21(5), IL21R(10), IL22(2), IL22RA1(4), IL22RA2(2), IL23A(3), IL23R(8), IL25(4), IL26(5), IL2RA(3), IL2RB(3), IL2RG(12), IL3(3), IL3RA(6), IL4(4), IL4R(10), IL5RA(12), IL6(1), IL6R(4), IL6ST(11), IL7(2), IL7R(18), IL9R(5), INHBA(19), INHBB(13), INHBC(8), INHBE(6), KDR(22), KIT(20), KITLG(6), LEP(3), LEPR(18), LIF(4), LIFR(18), LTA(4), LTBR(2), MET(14), MPL(7), NGFR(9), OSM(4), OSMR(13), PDGFB(8), PDGFC(11), PDGFRA(17), PDGFRB(16), PF4(2), PF4V1(3), PLEKHO2(3), PRL(3), PRLR(8), RELT(9), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TGFBR2(32), TNF(3), TNFRSF10A(3), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(3), TNFRSF11A(5), TNFRSF11B(6), TNFRSF12A(2), TNFRSF13B(7), TNFRSF13C(4), TNFRSF14(2), TNFRSF17(1), TNFRSF18(1), TNFRSF19(10), TNFRSF1A(6), TNFRSF1B(4), TNFRSF21(6), TNFRSF25(9), TNFRSF4(6), TNFRSF8(12), TNFRSF9(12), TNFSF10(10), TNFSF11(5), TNFSF12(2), TNFSF13(6), TNFSF13B(5), TNFSF14(4), TNFSF15(5), TNFSF18(2), TNFSF4(2), TNFSF8(4), TNFSF9(2), TPO(35), TSLP(2), VEGFB(2), VEGFC(17), XCL1(1), XCL2(1), XCR1(7) 152819552 1494 402 1420 487 364 204 182 384 354 6 0.115 1.000 1.000 195 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(5), ACTA2(12), ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ADM(2), ARRB1(8), ARRB2(3), ATF2(4), ATF3(2), ATF4(4), ATF5(5), ATP2A2(9), ATP2A3(14), CACNB3(4), CALCA(2), CALM1(2), CALM2(3), CALM3(2), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CNN1(4), CNN2(2), CORIN(15), CRHR1(14), DGKZ(12), ETS2(4), FOS(2), GABPA(5), GABPB2(4), GBA2(7), GJA1(14), GNAQ(4), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(4), GNG12(12), GNG13(3), GNG2(2), GNG7(4), GNGT1(4), GRK4(13), GRK5(4), GRK6(5), GSTO1(2), GUCA2A(1), GUCA2B(6), GUCY1A3(20), IGFBP1(11), IGFBP2(5), IGFBP3(7), IGFBP4(2), IGFBP6(1), IL1B(7), IL6(1), ITPR1(40), ITPR2(41), ITPR3(46), JUN(6), MAFF(1), MIB1(5), MYL2(9), MYL4(2), MYLK2(9), NFKB1(10), NOS1(45), NOS3(20), OXT(1), OXTR(9), PDE4B(9), PDE4D(11), PKIA(3), PKIG(1), PLCB3(21), PLCD1(7), PLCG1(27), PLCG2(22), PRKACA(9), PRKACB(6), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PRKCD(12), PRKCE(16), PRKCH(9), PRKCQ(18), PRKCZ(4), PRKD1(30), RAMP1(1), RAMP2(2), RAMP3(3), RGS1(4), RGS10(5), RGS11(7), RGS14(5), RGS16(3), RGS17(5), RGS18(10), RGS19(5), RGS2(7), RGS20(9), RGS3(21), RGS4(8), RGS5(2), RGS6(17), RGS7(7), RGS9(13), RLN1(5), RYR1(81), RYR2(141), RYR3(109), SFN(1), SLC8A1(26), SP1(6), TNXB(82), USP5(11), YWHAB(3), YWHAH(3), YWHAQ(5) 150279305 1636 402 1561 528 529 188 178 400 333 8 0.0159 1.000 1.000 196 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(5), ACTA2(12), ACTN2(34), ACTN4(20), DES(3), DMD(87), MYBPC1(13), MYBPC2(18), MYBPC3(18), MYH3(41), MYH6(34), MYH7(47), MYH8(23), MYL1(3), MYL2(9), MYL3(6), MYL4(2), MYL9(3), MYOM1(22), NEB(90), TCAP(4), TMOD1(4), TNNC2(1), TNNI1(1), TNNI2(6), TNNI3(1), TNNT1(6), TNNT2(6), TNNT3(7), TPM1(5), TPM2(3), TPM3(4), TPM4(5), TTN(728), VIM(12) 118443417 1283 391 1238 388 318 155 194 468 128 20 0.0580 1.000 1.000 197 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(36), ACACB(49), AKT1(7), AKT2(11), AKT3(10), ARAF(16), BAD(4), BRAF(22), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CBL(11), CBLB(6), CBLC(10), CRK(2), CRKL(2), EIF4EBP1(5), ELK1(6), EXOC7(15), FASN(34), FBP1(4), FBP2(8), FLOT2(14), FOXO1(7), G6PC2(1), GCK(10), GRB2(4), GSK3B(9), GYS1(10), GYS2(11), HRAS(2), IKBKB(12), INPP5D(12), INSR(26), IRS1(33), IRS2(13), IRS4(28), KRAS(40), LIPE(9), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(7), MKNK1(6), MKNK2(10), NRAS(5), PCK1(14), PCK2(12), PDE3A(26), PDE3B(26), PDPK1(1), PFKL(9), PFKM(6), PFKP(23), PHKA1(15), PHKA2(18), PHKB(11), PHKG1(4), PHKG2(13), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PKLR(12), PPARGC1A(16), PPP1CA(3), PPP1CB(1), PPP1CC(4), PPP1R3A(39), PPP1R3B(7), PPP1R3C(4), PPP1R3D(5), PRKAA1(9), PRKAA2(11), PRKAB1(13), PRKAB2(6), PRKACA(9), PRKACB(6), PRKACG(9), PRKAG1(6), PRKAG2(8), PRKAG3(8), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCI(8), PRKCZ(4), PRKX(6), PTPN1(8), PTPRF(24), PYGB(17), PYGL(14), PYGM(18), RAF1(11), RAPGEF1(15), RHEB(3), RHOQ(5), RPS6(1), RPS6KB1(6), RPS6KB2(9), SH2B2(5), SHC1(7), SHC2(3), SHC3(12), SHC4(11), SLC2A4(5), SOCS1(1), SOCS2(2), SOCS3(4), SOCS4(8), SORBS1(19), SOS1(12), SOS2(19), SREBF1(18), TRIP10(18), TSC1(20), TSC2(21) 138180102 1509 390 1357 405 435 250 169 311 336 8 1.44e-07 1.000 1.000 198 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(9), ACTB(10), ACTG1(2), ACTN1(8), ACTN2(34), ACTN4(20), ACVR1B(17), ACVR1C(7), BAIAP2(7), CDC42(3), CDH1(34), CREBBP(59), CSNK2A1(6), CSNK2A2(9), CTNNA1(24), CTNNA2(32), CTNNA3(29), CTNNB1(36), CTNND1(35), EGFR(24), EP300(39), ERBB2(35), FARP2(9), FER(16), FGFR1(19), FYN(10), IGF1R(24), INSR(26), IQGAP1(22), LEF1(5), LMO7(28), MAP3K7(14), MAPK1(4), MAPK3(3), MET(14), MLLT4(32), NLK(19), PARD3(24), PTPN1(8), PTPN6(6), PTPRB(28), PTPRF(24), PTPRJ(36), PTPRM(43), PVRL1(9), PVRL2(9), PVRL3(12), PVRL4(12), RAC1(2), RAC2(2), RAC3(4), RHOA(23), SMAD2(11), SMAD3(9), SMAD4(45), SNAI1(3), SNAI2(18), SORBS1(19), SRC(5), SSX2IP(12), TCF7(9), TCF7L1(10), TCF7L2(12), TGFBR1(10), TGFBR2(32), TJP1(32), VCL(19), WAS(4), WASF1(11), WASF2(10), WASF3(23), WASL(7), YES1(9) 103418455 1276 386 1178 311 333 182 144 294 313 10 7.38e-08 1.000 1.000 199 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA1(7), ADORA2A(7), ADORA2B(4), ADORA3(9), ADRA1A(26), ADRA1B(6), ADRA1D(9), ADRA2A(12), ADRA2C(6), ADRB1(10), ADRB2(9), ADRB3(6), AGTR1(1), AGTR2(6), AVPR1A(20), AVPR1B(3), AVPR2(12), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(13), CCKAR(8), CCKBR(19), CCR1(8), CCR10(4), CCR2(6), CCR3(14), CCR4(3), CCR5(5), CCR6(2), CCR7(5), CCR8(4), CCR9(8), CCRL2(1), CHML(13), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), CMKLR1(11), CNR1(16), CNR2(4), CX3CR1(7), CXCR3(3), CXCR4(1), DRD1(7), DRD2(14), DRD3(9), DRD4(6), DRD5(13), EDNRA(5), EDNRB(36), F2R(10), F2RL1(2), F2RL2(5), F2RL3(6), FPR1(9), FSHR(30), GALR1(8), GALR2(14), GALR3(5), GALT(3), GHSR(10), GNB2L1(5), GPR17(7), GPR173(8), GPR174(5), GPR27(8), GPR3(4), GPR35(5), GPR37(15), GPR37L1(10), GPR4(6), GPR50(12), GPR6(11), GPR63(6), GPR83(9), GPR85(6), GPR87(8), GRPR(7), HCRTR1(6), HCRTR2(14), HRH1(7), HRH2(9), HRH3(8), HTR1A(18), HTR1B(11), HTR1D(9), HTR1E(18), HTR1F(10), HTR2A(12), HTR2B(5), HTR2C(11), HTR4(5), HTR5A(14), HTR6(7), HTR7(17), LHCGR(24), LTB4R(2), MAS1(4), MC1R(8), MC3R(12), MC4R(11), MC5R(6), MLNR(5), MTNR1A(5), MTNR1B(10), NMBR(3), NMUR1(7), NMUR2(7), NPY1R(6), NPY2R(8), NPY5R(5), NTSR1(11), NTSR2(7), OPN1SW(2), OPN3(6), OPRD1(5), OPRK1(19), OPRL1(11), OPRM1(9), OR10A5(7), OR11A1(7), OR12D3(6), OR1C1(7), OR1F1(5), OR1Q1(8), OR2H1(3), OR5V1(9), OR7A5(3), OR7C1(8), OR8B8(7), OXTR(9), P2RY1(5), P2RY10(14), P2RY11(5), P2RY12(10), P2RY13(7), P2RY14(6), P2RY2(5), P2RY6(12), PTAFR(4), PTGDR(8), PTGER2(8), PTGER4(15), PTGFR(6), PTGIR(2), RGR(4), RHO(10), RRH(5), SSTR1(12), SSTR2(4), SSTR3(11), SSTR4(18), SUCNR1(6), TBXA2R(11), TRHR(7) 103542526 1354 382 1283 486 464 156 178 355 201 0 0.0256 1.000 1.000 200 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ADRB1(10), CSNK1D(5), DRD1(7), DRD2(14), EGF(15), EGFR(24), GJA1(14), GJD2(9), GNA11(6), GNAI1(4), GNAI2(5), GNAI3(9), GNAQ(4), GNAS(54), GRB2(4), GRM1(52), GRM5(42), GUCY1A2(17), GUCY1A3(20), GUCY1B3(10), GUCY2C(19), GUCY2D(19), GUCY2F(15), HRAS(2), HTR2A(12), HTR2B(5), HTR2C(11), ITPR1(40), ITPR2(41), ITPR3(46), KRAS(40), MAP2K1(9), MAP2K2(6), MAP2K5(3), MAP3K2(9), MAPK1(4), MAPK3(3), MAPK7(9), NPR1(17), NPR2(14), NRAS(5), PDGFA(4), PDGFB(8), PDGFC(11), PDGFD(11), PDGFRA(17), PDGFRB(16), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKG1(15), PRKG2(20), PRKX(6), RAF1(11), SOS1(12), SOS2(19), SRC(5), TJP1(32), TUBA1A(5), TUBA1B(3), TUBA1C(4), TUBA3C(17), TUBA3D(12), TUBA3E(11), TUBA4A(3), TUBA8(11), TUBAL3(8), TUBB(1), TUBB1(9), TUBB2A(7), TUBB2B(5), TUBB3(12), TUBB6(9), TUBB8(10) 114224183 1316 378 1232 419 405 207 148 340 210 6 0.00710 1.000 1.000 201 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(7), AKT2(11), AKT3(10), BCL2L1(2), CBL(11), CBLB(6), CBLC(10), CCND1(3), CCND2(2), CCND3(1), CISH(4), CLCF1(4), CNTF(4), CNTFR(6), CREBBP(59), CRLF2(3), CSF2RA(12), CSF2RB(18), CSF3(3), CSF3R(18), EP300(39), EPO(3), EPOR(5), GH1(3), GH2(4), GHR(11), GRB2(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNAR1(9), IFNAR2(4), IFNB1(4), IFNG(3), IFNGR1(11), IFNGR2(2), IFNK(1), IFNW1(4), IL10(4), IL10RA(8), IL10RB(3), IL11(3), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL13(4), IL13RA1(6), IL13RA2(10), IL15(2), IL15RA(6), IL19(2), IL20(3), IL20RA(5), IL21(5), IL21R(10), IL22(2), IL22RA1(4), IL22RA2(2), IL23A(3), IL23R(8), IL26(5), IL2RA(3), IL2RB(3), IL2RG(12), IL3(3), IL3RA(6), IL4(4), IL4R(10), IL5RA(12), IL6(1), IL6R(4), IL6ST(11), IL7(2), IL7R(18), IL9R(5), IRF9(7), JAK1(22), JAK2(14), JAK3(18), LEP(3), LEPR(18), LIF(4), LIFR(18), MPL(7), MYC(6), OSM(4), OSMR(13), PIAS1(17), PIAS2(14), PIAS3(11), PIAS4(9), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PIM1(2), PRL(3), PRLR(8), PTPN11(10), PTPN6(6), SOCS1(1), SOCS2(2), SOCS3(4), SOCS4(8), SOCS5(9), SOCS7(5), SOS1(12), SOS2(19), SPRED1(15), SPRED2(10), SPRY1(2), SPRY3(8), SPRY4(8), STAM(11), STAM2(9), STAT1(14), STAT2(10), STAT3(9), STAT4(14), STAT5A(13), STAT5B(15), STAT6(10), TPO(35), TSLP(2), TYK2(15) 125289057 1252 370 1132 353 283 188 175 317 284 5 0.00305 1.000 1.000 202 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(7), ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ADK(4), ADSL(8), ADSS(6), ADSSL1(10), AK1(1), AK5(8), AK7(7), ALLC(10), AMPD1(15), AMPD2(19), AMPD3(19), APRT(3), ATIC(7), CANT1(5), DCK(5), DGUOK(5), ENPP1(12), ENPP3(16), ENTPD1(6), ENTPD2(7), ENTPD3(6), ENTPD4(14), ENTPD5(5), ENTPD6(7), ENTPD8(7), FHIT(4), GART(12), GDA(8), GMPR(3), GMPR2(2), GMPS(10), GUCY1A2(17), GUCY1A3(20), GUCY1B3(10), GUCY2C(19), GUCY2D(19), GUCY2F(15), GUK1(4), IMPDH1(7), ITPA(1), NME2(3), NME4(2), NME6(4), NME7(4), NPR1(17), NPR2(14), NT5C1A(9), NT5C1B(14), NT5C2(9), NT5E(5), NT5M(7), NUDT2(5), NUDT5(1), NUDT9(2), PAPSS1(6), PAPSS2(9), PDE10A(24), PDE11A(16), PDE1A(10), PDE1C(17), PDE2A(19), PDE3B(26), PDE4A(13), PDE4B(9), PDE4C(10), PDE4D(11), PDE5A(11), PDE6D(1), PDE6G(1), PDE6H(3), PDE7A(8), PDE7B(5), PDE8A(16), PDE8B(11), PDE9A(10), PFAS(16), PKLR(12), PNPT1(6), POLA1(8), POLA2(6), POLD1(18), POLD2(8), POLD3(7), POLE(42), POLE2(6), POLE3(4), POLE4(1), POLR1A(23), POLR1B(11), POLR1C(9), POLR1D(4), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLR3A(31), POLR3B(16), POLR3G(3), POLR3H(2), POLR3K(2), PPAT(7), PRIM1(6), PRIM2(10), PRPS1(4), PRPS2(5), PRUNE(5), RFC5(3), RRM1(5), RRM2(3), RRM2B(5), XDH(32), ZNRD1(2) 140866896 1303 368 1264 420 366 169 185 331 249 3 0.121 1.000 1.000 203 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(8), ACTN2(34), ACTN4(20), ARHGAP5(34), BCAR1(16), CD99(1), CDC42(3), CDH5(15), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(7), CLDN17(8), CLDN18(4), CLDN19(7), CLDN2(2), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(10), CLDN7(1), CLDN8(3), CLDN9(9), CTNNA1(24), CTNNA2(32), CTNNA3(29), CTNNB1(36), CTNND1(35), CXCR4(1), CYBA(2), CYBB(10), ESAM(6), EZR(6), F11R(2), GNAI1(4), GNAI2(5), GNAI3(9), ICAM1(5), ITGA4(21), ITGAL(28), ITGAM(13), ITGB1(12), ITGB2(12), ITK(12), JAM2(2), JAM3(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MLLT4(32), MMP2(13), MMP9(23), MSN(18), MYL2(9), MYL7(5), MYL9(3), NCF1(4), NCF2(3), NCF4(5), NOX1(8), NOX3(12), OCLN(10), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG1(27), PLCG2(22), PRKCA(9), PRKCG(19), PTK2(12), PTK2B(20), PTPN11(10), PXN(9), RAC1(2), RAC2(2), RAP1A(4), RAP1B(6), RAPGEF3(5), RAPGEF4(22), RASSF5(6), RHOA(23), RHOH(1), ROCK1(22), ROCK2(20), SIPA1(12), THY1(1), TXK(3), VASP(2), VAV1(21), VAV2(14), VAV3(16), VCAM1(13), VCL(19) 107228020 1248 368 1121 338 348 187 156 284 262 11 4.45e-06 1.000 1.000 204 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(12), ACTN1(8), ACTR2(2), ACTR3(3), AKT1(7), AKT2(11), AKT3(10), ANGPTL2(9), ARHGEF6(13), ARHGEF7(13), BCAR1(16), BRAF(22), CAV1(6), CDC42(3), CDKN2A(36), CRK(2), CSE1L(11), DOCK1(29), EPHB2(19), FYN(10), GRB2(4), GRB7(9), ILK(11), ITGA1(10), ITGA10(19), ITGA11(18), ITGA2(18), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGB3BP(1), MAP2K4(12), MAP2K7(38), MAP3K11(12), MAPK1(4), MAPK10(7), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), MRAS(5), MYLK(31), MYLK2(9), P4HB(5), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PIK3CA(101), PIK3CB(17), PKLR(12), PLCG1(27), PLCG2(22), PTEN(43), PTK2(12), RAF1(11), RALA(1), RHO(10), ROCK1(22), ROCK2(20), SHC1(7), SOS1(12), SOS2(19), SRC(5), TERF2IP(6), TLN1(35), TLN2(43), VASP(2), WAS(4), ZYX(8) 105450424 1123 366 1021 282 319 182 122 232 255 13 6.03e-07 1.000 1.000 205 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(16), BRAF(22), CACNA1A(47), CRHR1(14), GNA11(6), GNA12(2), GNA13(10), GNAI1(4), GNAI2(5), GNAI3(9), GNAO1(2), GNAQ(4), GNAS(54), GNAZ(19), GRIA1(31), GRIA2(34), GRIA3(16), GRID2(30), GRM1(52), GRM5(42), GUCY1A2(17), GUCY1A3(20), GUCY1B3(10), GUCY2C(19), GUCY2D(19), GUCY2F(15), HRAS(2), IGF1(3), IGF1R(24), ITPR1(40), ITPR2(41), ITPR3(46), KRAS(40), LYN(9), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), NOS1(45), NOS3(20), NPR1(17), NPR2(14), NRAS(5), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PPP2CA(5), PPP2CB(4), PPP2R1A(18), PPP2R1B(10), PPP2R2A(10), PPP2R2B(9), PPP2R2C(7), PRKCA(9), PRKCG(19), PRKG1(15), PRKG2(20), RAF1(11), RYR1(81) 95479553 1197 363 1099 319 377 179 135 308 191 7 1.48e-06 1.000 1.000 206 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(12), ABL2(17), AKT1(7), AKT2(11), AKT3(10), ARAF(16), AREG(2), BAD(4), BRAF(22), BTC(2), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CBL(11), CBLB(6), CBLC(10), CDKN1A(7), CDKN1B(1), CRK(2), CRKL(2), EGF(15), EGFR(24), EIF4EBP1(5), ELK1(6), ERBB2(35), ERBB3(49), ERBB4(76), EREG(3), GAB1(5), GRB2(4), GSK3B(9), HBEGF(2), HRAS(2), JUN(6), KRAS(40), MAP2K1(9), MAP2K2(6), MAP2K4(12), MAP2K7(38), MAPK1(4), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(7), MYC(6), NCK1(7), NCK2(10), NRAS(5), NRG1(24), NRG2(11), NRG3(32), NRG4(2), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG1(27), PLCG2(22), PRKCA(9), PRKCG(19), PTK2(12), RAF1(11), RPS6KB1(6), RPS6KB2(9), SHC1(7), SHC2(3), SHC3(12), SHC4(11), SOS1(12), SOS2(19), SRC(5), STAT5A(13), STAT5B(15), TGFA(4) 88827162 1146 362 986 243 311 210 143 257 219 6 1.50e-14 1.000 1.000 207 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ATF4(4), CACNA1C(58), CACNA1D(50), CACNA1F(21), CACNA1S(31), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CDC42(3), CGA(1), EGFR(24), ELK1(6), FSHB(1), GNA11(6), GNAQ(4), GNAS(54), GNRH1(3), GNRH2(2), GNRHR(5), GRB2(4), HBEGF(2), HRAS(2), ITPR1(40), ITPR2(41), ITPR3(46), JUN(6), KRAS(40), LHB(3), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP2K7(38), MAP3K1(24), MAP3K2(9), MAP3K3(10), MAP3K4(32), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK7(9), MAPK8(7), MAPK9(7), MMP14(11), MMP2(13), NRAS(5), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLD1(26), PLD2(22), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCD(12), PRKX(6), PTK2B(20), RAF1(11), SOS1(12), SOS2(19), SRC(5) 110400671 1238 350 1152 372 390 183 135 285 234 11 0.000992 1.000 1.000 208 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), AKAP1(6), AKAP10(5), AKAP11(21), AKAP12(24), AKAP2(23), AKAP3(16), AKAP4(14), AKAP5(2), AKAP6(41), AKAP7(2), AKAP8(12), AKAP9(55), ARHGEF1(15), CALM1(2), CALM2(3), CALM3(2), CHMP1B(2), GNA11(6), GNA12(2), GNA13(10), GNA14(6), GNA15(6), GNAI2(5), GNAI3(9), GNAL(5), GNAO1(2), GNAQ(4), GNAZ(19), GNB1(2), GNB2(5), GNB3(2), GNB5(4), GNG10(1), GNG12(12), GNG13(3), GNG7(4), GNGT1(4), GNGT2(3), HRAS(2), IL18BP(3), ITPR1(40), KCNJ3(18), KRAS(40), NRAS(5), PALM2(11), PDE1A(10), PDE1B(8), PDE1C(17), PDE4A(13), PDE4B(9), PDE4C(10), PDE4D(11), PDE7A(8), PDE7B(5), PDE8A(16), PDE8B(11), PLCB3(21), PPP3CA(14), PPP3CC(9), PRKACA(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCI(8), PRKCQ(18), PRKCZ(4), PRKD1(30), PRKD3(7), RHOA(23), RRAS(1), SLC9A1(14), USP5(11) 100497411 1094 346 1001 325 291 162 147 274 217 3 0.00236 1.000 1.000 209 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM2(3), CALM3(2), CALML3(1), CDIPT(1), CDS1(6), CDS2(4), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKI(27), DGKQ(5), DGKZ(12), FN3K(6), IMPA1(8), IMPA2(2), INPP1(4), INPP4A(12), INPP4B(15), INPP5A(11), INPP5B(12), INPP5D(12), INPP5E(11), INPPL1(29), ITPK1(7), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), OCRL(10), PI4KA(29), PI4KB(11), PIK3C2A(20), PIK3C2B(25), PIK3C2G(18), PIK3C3(17), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PIP4K2A(9), PIP4K2B(9), PIP4K2C(2), PIP5K1A(4), PIP5K1B(2), PIP5K1C(15), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCD3(11), PLCD4(8), PLCE1(27), PLCG1(27), PLCG2(22), PLCZ1(14), PRKCA(9), PRKCG(19), PTEN(43), PTPMT1(2), SYNJ1(18), SYNJ2(24) 107853601 1109 344 991 262 309 164 137 240 245 14 2.26e-08 1.000 1.000 210 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(16), BID(3), BRAF(22), CASP3(2), CD244(5), CD247(4), CD48(1), FAS(3), FASLG(6), FCGR3A(6), FYN(10), GRB2(4), GZMB(2), HCST(1), HLA-A(23), HLA-B(36), HLA-C(11), HLA-E(7), HLA-G(7), HRAS(2), ICAM1(5), ICAM2(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNAR1(9), IFNAR2(4), IFNB1(4), IFNG(3), IFNGR1(11), IFNGR2(2), ITGAL(28), ITGB2(12), KIR2DL3(9), KIR3DL1(13), KIR3DL2(5), KLRC1(4), KLRC2(2), KLRC3(10), KLRD1(5), KLRK1(8), KRAS(40), LAT(3), LCK(5), LCP2(14), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MICA(4), MICB(6), NCR1(5), NCR2(5), NCR3(1), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NRAS(5), PAK1(7), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG1(27), PLCG2(22), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRF1(17), PRKCA(9), PRKCG(19), PTK2B(20), PTPN11(10), PTPN6(6), RAC1(2), RAC2(2), RAC3(4), RAF1(11), SH2D1A(1), SH2D1B(3), SH3BP2(7), SHC1(7), SHC2(3), SHC3(12), SHC4(11), SOS1(12), SOS2(19), SYK(11), TNF(3), TNFRSF10A(3), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(3), TNFSF10(10), TYROBP(4), ULBP1(6), ULBP2(1), ULBP3(1), VAV1(21), VAV2(14), VAV3(16), ZAP70(16) 97860050 1151 338 996 260 270 199 139 269 268 6 1.56e-11 1.000 1.000 211 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(7), AKT2(11), AKT3(10), BCL10(3), CARD11(32), CBL(11), CBLB(6), CBLC(10), CD247(4), CD28(2), CD3E(3), CD4(11), CD40LG(6), CD8A(4), CD8B(2), CDC42(3), CDK4(2), CHUK(10), CTLA4(4), FOS(2), FYN(10), GRAP2(9), GRB2(4), HRAS(2), ICOS(4), IFNG(3), IKBKB(12), IL10(4), IL4(4), ITK(12), JUN(6), KRAS(40), LAT(3), LCK(5), LCP2(14), MALT1(4), MAP3K8(2), NCK1(7), NCK2(10), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(5), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PDCD1(6), PDK1(3), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKCQ(18), PTPN6(6), PTPRC(30), RASGRP1(11), RHOA(23), SOS1(12), SOS2(19), TEC(5), TNF(3), VAV1(21), VAV2(14), VAV3(16), ZAP70(16) 87427190 984 336 842 235 248 179 129 235 190 3 3.30e-08 1.000 1.000 212 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(26), ADCY8(48), ARAF(16), ATF4(4), BRAF(22), CACNA1C(58), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), CREBBP(59), EP300(39), GNAQ(4), GRIA1(31), GRIA2(34), GRIN1(11), GRIN2A(23), GRIN2B(31), GRIN2C(13), GRIN2D(12), GRM1(52), GRM5(42), HRAS(2), ITPR1(40), ITPR2(41), ITPR3(46), KRAS(40), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), NRAS(5), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PPP1CA(3), PPP1CB(1), PPP1CC(4), PPP1R12A(4), PPP1R1A(3), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), RAF1(11), RAP1A(4), RAP1B(6), RAPGEF3(5), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA6(24) 86332483 1028 334 954 293 288 161 122 254 196 7 0.000130 1.000 1.000 213 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ASIP(2), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CREB1(4), CREB3L1(7), CREB3L2(5), CREB3L3(6), CREB3L4(4), CREBBP(59), CTNNB1(36), DCT(20), DVL1(8), DVL2(11), DVL3(17), EDN1(4), EDNRB(36), EP300(39), FZD1(15), FZD10(22), FZD2(17), FZD3(13), FZD4(9), FZD5(6), FZD6(13), FZD7(15), FZD8(14), FZD9(5), GNAI1(4), GNAI2(5), GNAI3(9), GNAO1(2), GNAQ(4), GNAS(54), GSK3B(9), HRAS(2), KIT(20), KITLG(6), KRAS(40), LEF1(5), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MC1R(8), MITF(11), NRAS(5), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), POMC(11), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), RAF1(11), TCF7(9), TCF7L1(10), TCF7L2(12), TYR(18), TYRP1(10), WNT1(11), WNT10A(6), WNT10B(3), WNT11(3), WNT16(16), WNT2(6), WNT2B(14), WNT3(6), WNT3A(9), WNT4(2), WNT5A(8), WNT5B(6), WNT6(4), WNT7A(6), WNT7B(10), WNT8A(2), WNT8B(2), WNT9A(9), WNT9B(6) 93786570 1192 331 1078 358 398 165 140 257 228 4 0.000164 1.000 1.000 214 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(6), ACVR1B(17), ACVRL1(10), AKT1(7), AURKB(6), BMPR1A(13), BMPR2(24), BUB1(15), CDIPT(1), CDKL2(6), CDS1(6), CDS2(4), CLK1(6), CLK2(15), CLK4(8), COL4A3BP(6), CSNK2A1(6), CSNK2A2(9), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKQ(5), DGKZ(12), IMPA1(8), INPP1(4), INPP4A(12), INPP4B(15), INPP5A(11), INPPL1(29), ITPKA(2), ITPKB(20), MAP3K10(17), MOS(11), NEK1(9), NEK3(5), OCRL(10), PAK4(11), PIK3C2A(20), PIK3C2B(25), PIK3C2G(18), PIK3CA(101), PIK3CB(17), PIK3CG(25), PIM2(3), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCG1(27), PLCG2(22), PLK3(10), PRKACA(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCQ(18), PRKCZ(4), PRKD1(30), PRKG1(15), RAF1(11), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA4(13), RPS6KB1(6), STK11(11), TGFBR1(10), VRK1(3) 97927091 1034 331 924 227 270 151 139 224 243 7 8.86e-09 1.000 1.000 215 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(6), ACVR1B(17), ACVR1C(7), ACVR2A(11), ACVR2B(6), ACVRL1(10), AMHR2(11), BMP2(8), BMP4(6), BMP5(12), BMP6(14), BMP7(9), BMP8A(1), BMP8B(5), BMPR1A(13), BMPR1B(13), BMPR2(24), CDKN2B(1), CHRD(15), COMP(8), CREBBP(59), CUL1(28), DCN(16), E2F4(2), E2F5(5), EP300(39), FST(6), GDF5(15), GDF6(20), GDF7(5), ID1(2), ID2(1), ID3(2), ID4(1), IFNG(3), INHBA(19), INHBB(13), INHBC(8), INHBE(6), LEFTY1(3), LEFTY2(4), LTBP1(32), MAPK1(4), MAPK3(3), MYC(6), NODAL(2), NOG(3), PITX2(6), PPP2CA(5), PPP2CB(4), PPP2R1A(18), PPP2R1B(10), PPP2R2A(10), PPP2R2B(9), PPP2R2C(7), RBL1(14), RBL2(11), RBX1(1), RHOA(23), ROCK1(22), ROCK2(20), RPS6KB1(6), RPS6KB2(9), SMAD1(4), SMAD2(11), SMAD3(9), SMAD4(45), SMAD5(2), SMAD6(8), SMAD7(7), SMAD9(15), SMURF1(9), SMURF2(7), SP1(6), TFDP1(6), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TGFBR2(32), THBS1(19), THBS2(24), THBS3(13), THBS4(18), TNF(3), ZFYVE16(17), ZFYVE9(14) 84934505 982 330 919 264 265 122 125 211 253 6 0.000589 1.000 1.000 216 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(7), AKT3(10), BCAR1(16), CAPN1(8), CAPN10(10), CAPN11(10), CAPN2(11), CAPN3(11), CAPN5(14), CAPN6(13), CAPN7(7), CAPN9(7), CAPNS1(6), CAV1(6), CAV2(1), CAV3(2), CDC42(3), CRK(2), CSK(10), DOCK1(29), FYN(10), GIT2(7), GRB2(4), ILK(11), ITGA10(19), ITGA11(18), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGAD(23), ITGAE(19), ITGAL(28), ITGAM(13), ITGAV(23), ITGAX(15), ITGB1(12), ITGB2(12), ITGB3(8), ITGB4(29), ITGB5(10), ITGB6(9), ITGB7(7), ITGB8(18), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K6(1), MAPK10(7), MAPK12(1), MAPK4(10), MAPK6(6), MAPK7(9), MYLK2(9), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PDPK1(1), PIK3R2(16), PTK2(12), PXN(9), RAC1(2), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(15), RHO(10), ROCK1(22), ROCK2(20), SDCCAG8(9), SHC1(7), SHC3(12), SORBS1(19), SOS1(12), SRC(5), TLN1(35), TNS1(46), VASP(2), VAV2(14), VAV3(16), VCL(19), ZYX(8) 115902980 1074 329 1035 313 318 151 128 226 245 6 0.00135 1.000 1.000 217 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(7), ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADK(4), ADSL(8), ADSS(6), AK1(1), AK5(8), ALLC(10), AMPD1(15), AMPD2(19), AMPD3(19), APRT(3), ATIC(7), ATP1B1(8), ATP5A1(5), ATP5B(10), ATP5C1(7), ATP5F1(5), ATP5G2(2), ATP5G3(2), ATP5H(1), ATP5J(3), ATP5J2(1), CANT1(5), DCK(5), DGUOK(5), ENPP1(12), ENPP3(16), ENTPD1(6), ENTPD2(7), FHIT(4), GART(12), GDA(8), GMPS(10), GUCY1A2(17), GUCY1A3(20), GUCY1B3(10), GUCY2C(19), GUCY2D(19), GUCY2F(15), GUK1(4), IMPDH1(7), ITPA(1), NME2(3), NPR1(17), NPR2(14), NT5E(5), NT5M(7), NUDT2(5), PAPSS1(6), PAPSS2(9), PDE1A(10), PDE4A(13), PDE4B(9), PDE4C(10), PDE4D(11), PDE5A(11), PDE6B(15), PDE6C(8), PDE6G(1), PDE7B(5), PDE8A(16), PDE9A(10), PFAS(16), PKLR(12), POLB(8), POLD1(18), POLD2(8), POLE(42), POLG(10), POLL(4), POLQ(46), POLR1B(11), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLRMT(17), PPAT(7), PRPS1(4), PRPS2(5), PRUNE(5), RRM1(5), RRM2(3) 110487457 1015 325 986 349 272 145 145 251 199 3 0.523 1.000 1.000 218 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(7), AKT2(11), AKT3(10), BAD(4), BCL2L1(2), CDC42(3), CDK2(5), CDKN1B(1), CDKN2A(36), CREB1(4), CREB5(9), EBP(2), ERBB4(76), F2RL2(5), GAB1(5), GRB2(4), GSK3A(6), GSK3B(9), IFI27(3), IGF1(3), IGFBP1(11), INPPL1(29), IRS1(33), IRS2(13), IRS4(28), MET(14), MYC(6), NOLC1(16), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PARD3(24), PARD6A(1), PDK1(3), PIK3CA(101), PIK3CD(20), PPP1R13B(19), PREX1(26), PTEN(43), PTK2(12), PTPN1(8), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SLC2A4(5), SOS1(12), SOS2(19), TSC1(20), TSC2(21), YWHAB(3), YWHAE(5), YWHAG(4), YWHAH(3), YWHAQ(5), YWHAZ(4) 66421705 825 315 714 170 199 127 107 175 209 8 1.14e-09 1.000 1.000 219 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(18), AMY2A(9), AMY2B(23), ASCC3(41), ATP13A2(20), DDX18(17), DDX19A(8), DDX23(15), DDX4(12), DDX41(11), DDX47(2), DDX50(14), DDX51(11), DDX52(8), DDX54(18), DDX55(7), DDX56(11), DHX58(12), ENPP1(12), ENPP3(16), ENTPD7(11), EP400(55), ERCC2(11), ERCC3(9), G6PC2(1), GAA(11), GANC(10), GBA(14), GBE1(10), GCK(10), GPI(6), GUSB(12), GYS1(10), GYS2(11), HK1(18), HK2(15), HK3(13), IFIH1(13), LYZL1(4), MGAM(28), MOV10L1(13), NUDT5(1), NUDT8(2), PGM1(4), PGM3(13), PYGB(17), PYGL(14), PYGM(18), RAD54B(5), RAD54L(5), RUVBL2(10), SETX(31), SI(49), SKIV2L2(18), SMARCA2(39), SMARCA5(12), TREH(3), UGDH(11), UGP2(9), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7), UXS1(9) 106848765 952 311 912 274 223 112 131 259 224 3 0.0955 1.000 1.000 220 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(32), ABCA10(29), ABCA12(58), ABCA13(82), ABCA2(34), ABCA3(25), ABCA4(26), ABCA5(26), ABCA6(27), ABCA7(27), ABCA8(17), ABCA9(22), ABCB1(40), ABCB10(16), ABCB11(17), ABCB4(33), ABCB5(24), ABCB6(18), ABCB7(6), ABCB8(14), ABCB9(6), ABCC1(17), ABCC10(15), ABCC11(28), ABCC12(23), ABCC2(23), ABCC3(16), ABCC4(26), ABCC5(18), ABCC6(17), ABCC8(29), ABCC9(57), ABCD1(10), ABCD2(8), ABCD3(6), ABCD4(9), ABCG1(15), ABCG2(11), ABCG4(5), ABCG5(4), ABCG8(9), CFTR(23), TAP1(5), TAP2(11) 102163366 964 308 917 245 247 140 119 229 222 7 1.32e-06 1.000 1.000 221 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(7), AKT2(11), AKT3(10), CASP8(24), CCL3(1), CCL5(4), CD14(2), CD40(3), CD80(6), CD86(8), CHUK(10), CXCL10(1), CXCL9(2), FADD(4), FOS(2), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNAR1(9), IFNAR2(4), IFNB1(4), IKBKB(12), IKBKE(14), IL12A(3), IL12B(3), IL1B(7), IL6(1), IRAK1(9), IRAK4(4), IRF3(3), IRF5(7), IRF7(4), JUN(6), LBP(3), LY96(5), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP2K7(38), MAP3K7(14), MAP3K8(2), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(7), MYD88(4), NFKB1(10), NFKB2(11), NFKBIA(1), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), RAC1(2), RELA(7), RIPK1(5), SPP1(4), STAT1(14), TBK1(8), TICAM1(9), TIRAP(1), TLR1(10), TLR2(9), TLR3(7), TLR4(33), TLR5(11), TLR6(6), TLR7(7), TLR8(15), TLR9(15), TNF(3), TOLLIP(7), TRAF3(8), TRAF6(7) 76755778 793 300 703 193 190 120 120 186 172 5 2.40e-06 1.000 1.000 222 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(3), ALG1(9), ALG10(17), ALG10B(11), ALG11(9), ALG12(13), ALG13(9), ALG14(3), ALG2(3), ALG3(4), ALG6(6), ALG8(3), ALG9(3), B3GNT1(8), B3GNT2(6), B3GNT6(6), B3GNT7(7), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT4(7), B4GALT5(5), B4GALT7(9), C1GALT1(4), C1GALT1C1(6), CHPF(8), CHST1(21), CHST11(4), CHST12(7), CHST13(6), CHST14(3), CHST2(15), CHST3(10), CHST4(7), CHST6(13), CHST7(8), CHSY1(12), DDOST(1), DPAGT1(6), EXT1(26), EXT2(8), EXTL1(8), EXTL2(2), EXTL3(15), FUT11(4), FUT8(11), GALNT1(4), GALNT10(10), GALNT11(7), GALNT12(6), GALNT13(14), GALNT14(15), GALNT2(9), GALNT3(6), GALNT4(6), GALNT5(14), GALNT6(7), GALNT7(4), GALNT8(12), GALNT9(6), GALNTL5(5), GANAB(21), GCNT1(4), GCNT3(5), GCNT4(8), HS2ST1(4), HS3ST1(10), HS3ST2(12), HS3ST3A1(5), HS3ST3B1(5), HS3ST5(10), HS6ST1(9), HS6ST2(11), HS6ST3(9), MAN1A1(6), MAN1A2(7), MAN1B1(8), MAN1C1(11), MAN2A1(10), MGAT1(6), MGAT2(4), MGAT3(13), MGAT4A(6), MGAT4B(6), MGAT5(14), MGAT5B(15), NDST1(18), NDST2(18), NDST3(23), NDST4(23), OGT(10), RPN1(7), RPN2(9), ST3GAL1(7), ST3GAL2(11), ST3GAL3(3), ST3GAL4(8), ST6GAL1(1), ST6GALNAC1(7), STT3B(10), UST(10), WBSCR17(37), XYLT1(14), XYLT2(46) 94851042 971 298 893 332 294 111 108 234 220 4 0.809 1.000 1.000 223 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(7), AKT2(11), AKT3(10), BTK(5), FCER1A(5), FYN(10), GAB2(14), GRB2(4), HRAS(2), IL13(4), IL3(3), IL4(4), INPP5D(12), KRAS(40), LAT(3), LCP2(14), LYN(9), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP2K7(38), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(7), MS4A2(3), NRAS(5), PDK1(3), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCG1(27), PLCG2(22), PRKCA(9), PRKCD(12), PRKCE(16), RAC1(2), RAC2(2), RAC3(4), RAF1(11), SOS1(12), SOS2(19), SYK(11), TNF(3), VAV1(21), VAV2(14), VAV3(16) 62199845 761 297 634 158 201 146 101 179 130 4 1.54e-11 1.000 1.000 224 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(28), BDKRB1(4), BDKRB2(3), C1QA(5), C1QB(3), C1QC(5), C1R(1), C1S(11), C2(4), C3(43), C3AR1(13), C4BPA(6), C4BPB(4), C5(15), C5AR1(7), C6(19), C7(11), C8A(13), C8B(14), C9(10), CD46(8), CD55(4), CD59(1), CFB(8), CFH(37), CFI(15), CPB2(11), CR1(35), CR2(29), F10(10), F11(9), F12(5), F13A1(20), F13B(20), F2(15), F2R(10), F3(2), F5(26), F7(12), F8(36), F9(10), FGA(16), FGB(9), FGG(6), KLKB1(7), KNG1(13), MASP1(7), MASP2(6), MBL2(8), PLAT(8), PLAUR(6), PLG(21), PROC(5), PROS1(16), SERPINA1(9), SERPINA5(9), SERPINC1(5), SERPIND1(5), SERPINE1(3), SERPINF2(10), SERPING1(10), TFPI(7), THBD(5), VWF(47) 77928104 780 289 742 196 188 100 101 205 185 1 0.000369 1.000 1.000 225 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(11), CD14(2), CD19(5), CD1A(18), CD1B(10), CD1C(14), CD1D(15), CD1E(17), CD2(5), CD22(10), CD33(11), CD34(6), CD36(7), CD37(2), CD38(7), CD3E(3), CD4(11), CD44(8), CD5(6), CD55(4), CD59(1), CD7(6), CD8A(4), CD8B(2), CD9(2), CR1(35), CR2(29), CSF1(6), CSF1R(26), CSF2RA(12), CSF3(3), CSF3R(18), DNTT(6), EPO(3), EPOR(5), FCER2(5), FCGR1A(4), FLT3(21), FLT3LG(2), GP5(15), GP9(3), HLA-DRA(7), HLA-DRB1(2), HLA-DRB5(3), IL11(3), IL11RA(3), IL1A(2), IL1B(7), IL1R1(5), IL1R2(13), IL2RA(3), IL3(3), IL3RA(6), IL4(4), IL4R(10), IL5RA(12), IL6(1), IL6R(4), IL7(2), IL7R(18), IL9R(5), ITGA1(10), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGAM(13), ITGB3(8), KIT(20), KITLG(6), MME(14), MS4A1(2), TFRC(4), THPO(8), TNF(3), TPO(35) 70511442 712 289 665 183 156 90 88 199 176 3 0.000929 1.000 1.000 226 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(9), ALG6(6), CCKBR(19), CCR2(6), CCR3(14), CCR5(5), CELSR1(51), CELSR2(51), CELSR3(65), CHRM2(27), CHRM3(17), CIDEB(2), CXCR3(3), DRD4(6), EDNRA(5), EMR2(12), EMR3(7), F2R(10), FSHR(30), GHRHR(6), GNRHR(5), GPR116(19), GPR132(6), GPR133(19), GPR135(11), GPR143(4), GPR17(7), GPR18(4), GPR55(10), GPR56(13), GPR61(9), GPR84(6), GPR88(1), GRM1(52), GRPR(7), HRH4(10), LGR6(20), LPHN2(32), LPHN3(32), LTB4R2(6), NTSR1(11), OR2M4(10), P2RY11(5), P2RY13(7), PTGFR(6), SMO(19), SSTR2(4), TAAR5(7), TSHR(15), VN1R1(7) 56994189 715 283 683 192 216 91 90 205 111 2 2.84e-05 1.000 1.000 227 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(7), AKT2(11), AKT3(10), BAD(4), CASP9(4), CDC42(3), HRAS(2), KDR(22), KRAS(40), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPKAPK2(4), MAPKAPK3(5), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NOS3(20), NRAS(5), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCG1(27), PLCG2(22), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKCA(9), PRKCG(19), PTGS2(7), PTK2(12), PXN(9), RAC1(2), RAC2(2), RAC3(4), RAF1(11), SH2D2A(8), SHC2(3), SPHK1(10), SPHK2(11), SRC(5) 62181862 737 283 609 146 209 152 93 157 125 1 2.28e-14 1.000 1.000 228 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(10), BAD(4), BCL2(4), CABIN1(28), CALM1(2), CALM2(3), CALM3(2), CAMK2B(9), CAMK4(10), CD3E(3), CD69(4), CDKN1A(7), CNR1(16), CREBBP(59), CSNK2A1(6), CTLA4(4), EGR2(9), EGR3(9), EP300(39), FCER1A(5), FCGR3A(6), FOS(2), FOSL1(3), GATA3(23), GATA4(4), GSK3A(6), GSK3B(9), HRAS(2), ICOS(4), IFNA1(1), IFNB1(4), IFNG(3), IL10(4), IL13(4), IL1B(7), IL2RA(3), IL3(3), IL4(4), IL6(1), ITK(12), JUNB(5), KPNA5(9), MAP2K7(38), MAPK14(3), MAPK8(7), MAPK9(7), MEF2A(3), MEF2B(6), MEF2D(11), MYF5(6), NCK2(10), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB2(11), NFKBIB(8), NFKBIE(1), NPPB(3), NUP214(31), OPRD1(5), P2RX7(4), PAK1(7), PIN1(2), PPP3CB(8), PPP3CC(9), PPP3R1(3), PTPRC(30), RELA(7), RPL13A(5), SFN(1), SLA(9), SP1(6), SP3(7), TGFB1(3), TNF(3), TRAF2(5), TRPV6(12), VAV1(21), VAV2(14), VAV3(16), XPO5(6) 78558389 776 279 741 218 220 106 91 185 170 4 0.00123 1.000 1.000 229 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(7), AKT2(11), AKT3(10), BCL10(3), BLNK(8), BTK(5), CARD11(32), CD19(5), CD22(10), CD72(1), CD79A(10), CD79B(3), CD81(7), CHUK(10), CR2(29), FCGR2B(4), FOS(2), GSK3B(9), HRAS(2), IFITM1(5), IKBKB(12), INPP5D(12), JUN(6), KRAS(40), LILRB3(7), LYN(9), MALT1(4), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(5), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG2(22), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PTPN6(6), RAC1(2), RAC2(2), RAC3(4), RASGRP3(8), SYK(11), VAV1(21), VAV2(14), VAV3(16) 64080459 756 279 624 172 195 151 102 156 149 3 3.72e-09 1.000 1.000 230 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(3), AKT1(7), AKT2(11), AKT3(10), ANGPTL2(9), ARHGAP1(8), ARHGAP4(4), ARHGEF11(26), BTK(5), CDC42(3), CFL1(2), CFL2(1), GDI1(6), GDI2(7), INPPL1(29), ITPR1(40), ITPR2(41), ITPR3(46), LIMK1(7), MYLK(31), MYLK2(9), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PDK1(3), PIK3CA(101), PIK3CD(20), PIK3CG(25), PIK3R1(17), PITX2(6), PPP1R13B(19), PTEN(43), RACGAP1(9), RHO(10), ROCK1(22), ROCK2(20), RPS4X(2), SAG(5), WASF1(11), WASL(7) 60463520 696 274 597 159 177 107 102 141 156 13 1.94e-06 1.000 1.000 231 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(7), AKT2(11), AKT3(10), BAD(4), BCL2(4), BCR(18), BLNK(8), BTK(5), CD19(5), CD22(10), CD81(7), CR2(29), CSK(10), DAG1(14), FLOT2(14), GRB2(4), GSK3A(6), GSK3B(9), INPP5D(12), ITPR1(40), ITPR2(41), ITPR3(46), LYN(9), MAP4K1(4), MAPK1(4), MAPK3(3), NFATC1(20), NFATC2(32), NR0B2(4), PDK1(3), PIK3CA(101), PIK3CD(20), PIK3R1(17), PLCG2(22), PPP1R13B(19), PPP3CA(14), PPP3CB(8), PPP3CC(9), PTPRC(30), RAF1(11), SHC1(7), SOS1(12), SOS2(19), SYK(11), VAV1(21) 63624604 714 272 621 180 200 109 87 168 145 5 1.49e-05 1.000 1.000 232 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(6), IMPA1(8), IMPA2(2), INPP1(4), INPP4A(12), INPP4B(15), INPP5A(11), INPP5B(12), INPP5E(11), INPPL1(29), IPMK(2), ISYNA1(5), ITPK1(7), ITPKA(2), ITPKB(20), MINPP1(6), MIOX(8), OCRL(10), PI4KA(29), PI4KB(11), PIK3C3(17), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIP4K2A(9), PIP4K2B(9), PIP4K2C(2), PIP5K1A(4), PIP5K1B(2), PIP5K1C(15), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCD3(11), PLCD4(8), PLCE1(27), PLCG1(27), PLCG2(22), PLCZ1(14), PTEN(43), PTPMT1(2), SYNJ1(18), SYNJ2(24) 64134149 710 268 612 156 193 121 89 154 145 8 3.74e-08 1.000 1.000 233 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(7), AKT2(11), AKT3(10), BRD4(23), CAP1(2), CBL(11), CDC42(3), CDKN2A(36), F2RL2(5), FLOT2(14), GRB2(4), GSK3A(6), GSK3B(9), IGFBP1(11), INPPL1(29), IRS1(33), IRS2(13), IRS4(28), LNPEP(15), MAPK1(4), MAPK3(3), PARD3(24), PARD6A(1), PDK1(3), PIK3CA(101), PIK3CD(20), PIK3R1(17), PTEN(43), PTPN1(8), RAF1(11), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), SERPINB6(5), SFN(1), SHC1(7), SLC2A4(5), SORBS1(19), SOS1(12), SOS2(19), YWHAB(3), YWHAE(5), YWHAG(4), YWHAH(3), YWHAQ(5), YWHAZ(4) 50940554 632 264 535 141 161 109 72 116 166 8 4.87e-06 1.000 1.000 234 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(7), AKT2(11), AKT3(10), BCR(18), BTK(5), CD19(5), CDKN2A(36), DAPP1(2), FLOT2(14), GAB1(5), ITPR1(40), ITPR2(41), ITPR3(46), LYN(9), NR0B2(4), PDK1(3), PHF11(5), PIK3CA(101), PITX2(6), PLCG2(22), PPP1R13B(19), PREX1(26), PTEN(43), PTPRC(30), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), SAG(5), SYK(11), TEC(5), VAV1(21) 47774251 585 264 496 141 150 96 71 135 125 8 3.15e-05 1.000 1.000 235 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(45), ASH2L(5), CARM1(10), CTCFL(16), DOT1L(23), EED(9), EHMT1(24), EHMT2(23), EZH1(10), EZH2(6), FBXO11(16), HCFC1(23), HSF4(10), JMJD4(4), JMJD6(5), KDM6A(22), MEN1(11), NSD1(41), OGT(10), PAXIP1(17), PPP1CA(3), PPP1CB(1), PPP1CC(4), PRDM2(40), PRDM7(4), PRDM9(33), PRMT1(5), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), RBBP5(7), SATB1(20), SETD1A(29), SETD1B(3), SETD2(27), SETD7(3), SETD8(3), SETDB1(20), SETDB2(17), SETMAR(4), SMYD3(3), STK38(8), SUV39H1(6), SUV39H2(2), SUV420H1(23), SUV420H2(9), SUZ12(4), WHSC1(30), WHSC1L1(23) 103841678 688 263 661 170 176 82 84 166 171 9 0.00503 1.000 1.000 236 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(4), BRAF(22), CEBPA(2), CHUK(10), CREB1(4), DAXX(14), ELK1(6), FOS(2), GRB2(4), HRAS(2), IKBKB(12), JUN(6), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K5(3), MAP2K6(1), MAP2K7(38), MAP3K1(24), MAP3K10(17), MAP3K11(12), MAP3K12(17), MAP3K13(14), MAP3K2(9), MAP3K3(10), MAP3K4(32), MAP3K5(18), MAP3K6(14), MAP3K7(14), MAP3K8(2), MAP3K9(7), MAP4K1(4), MAP4K2(14), MAP4K3(8), MAP4K4(16), MAP4K5(10), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK4(10), MAPK6(6), MAPK7(9), MAPK8(7), MAPK9(7), MAPKAPK2(4), MAPKAPK3(5), MAPKAPK5(6), MAX(4), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), MKNK1(6), MKNK2(10), MYC(6), NFKB1(10), NFKBIA(1), PAK1(7), PAK2(13), RAC1(2), RAF1(11), RELA(7), RIPK1(5), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA4(13), RPS6KA5(9), RPS6KB1(6), RPS6KB2(9), SHC1(7), SP1(6), STAT1(14), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TRADD(2), TRAF2(5) 82786422 731 263 699 194 206 93 77 156 193 6 0.00396 1.000 1.000 237 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(68), AXIN1(17), CCND1(3), CCND2(2), CCND3(1), CSNK1E(10), CTNNB1(36), DVL1(8), DVL2(11), DVL3(17), FBXW2(4), FOSL1(3), FZD1(15), FZD10(22), FZD2(17), FZD3(13), FZD5(6), FZD6(13), FZD7(15), FZD8(14), FZD9(5), GSK3B(9), JUN(6), LDLR(15), MAPK10(7), MAPK9(7), MYC(6), PAFAH1B1(16), PPP2R5C(10), PPP2R5E(5), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCI(8), PRKCQ(18), PRKCZ(4), PRKD1(30), RAC1(2), RHOA(23), SFRP4(8), TCF7(9), WNT1(11), WNT10A(6), WNT10B(3), WNT11(3), WNT16(16), WNT2(6), WNT2B(14), WNT3(6), WNT4(2), WNT5A(8), WNT5B(6), WNT6(4), WNT7A(6), WNT7B(10) 51434876 649 262 590 188 194 66 67 146 168 8 0.0158 1.000 1.000 238 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(22), CPEB1(7), EGFR(24), ERBB2(35), ERBB4(76), ETS1(9), ETS2(4), ETV6(9), ETV7(6), FMN2(64), GRB2(4), KRAS(40), MAP2K1(9), MAPK1(4), MAPK3(3), NOTCH1(51), NOTCH2(39), NOTCH3(39), NOTCH4(29), PIWIL1(10), PIWIL2(13), PIWIL3(7), PIWIL4(9), RAF1(11), SOS1(12), SOS2(19), SPIRE1(11), SPIRE2(9) 45332697 575 261 498 147 133 107 58 163 111 3 0.00129 1.000 1.000 239 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(7), APOA1(9), CD36(7), CITED2(6), CPT1B(13), CREBBP(59), DUSP1(3), DUT(3), EHHADH(5), EP300(39), HSD17B4(11), HSPA1A(4), JUN(6), LPL(11), MAPK1(4), MAPK3(3), ME1(2), MRPL11(1), MYC(6), NCOA1(27), NCOR1(34), NCOR2(52), NFKBIA(1), NR0B2(4), NR1H3(5), NR2F1(11), NRIP1(21), PDGFA(4), PIK3CA(101), PIK3R1(17), PPARA(8), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PTGS2(7), RB1(22), RELA(7), RXRA(13), SP1(6), STAT5A(13), STAT5B(15), TNF(3) 54412287 623 258 544 152 143 103 86 130 156 5 6.70e-05 1.000 1.000 240 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(8), BMP4(6), BMP5(12), BMP6(14), BMP7(9), BMP8A(1), BMP8B(5), BTRC(12), CSNK1A1(7), CSNK1A1L(8), CSNK1D(5), CSNK1E(10), CSNK1G1(7), CSNK1G2(8), CSNK1G3(10), DHH(2), FBXW11(9), GAS1(6), GLI1(28), GLI2(23), GLI3(69), GSK3B(9), HHIP(24), IHH(9), LRP2(81), PRKACA(9), PRKACB(6), PRKACG(9), PRKX(6), PTCH1(42), PTCH2(17), RAB23(2), SHH(6), SMO(19), STK36(12), SUFU(8), WNT1(11), WNT10A(6), WNT10B(3), WNT11(3), WNT16(16), WNT2(6), WNT2B(14), WNT3(6), WNT3A(9), WNT4(2), WNT5A(8), WNT5B(6), WNT6(4), WNT7A(6), WNT7B(10), WNT8A(2), WNT8B(2), WNT9A(9), WNT9B(6), ZIC2(10) 52064147 657 246 607 187 216 84 66 136 149 6 0.00893 1.000 1.000 241 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(49), ACSL1(6), ACSL3(10), ACSL4(7), ACSL5(8), ACSL6(10), ADIPOQ(5), ADIPOR1(7), ADIPOR2(6), AGRP(2), AKT1(7), AKT2(11), AKT3(10), CAMKK1(5), CAMKK2(6), CD36(7), CHUK(10), CPT1A(16), CPT1B(13), CPT1C(12), CPT2(8), G6PC2(1), IKBKB(12), IRS1(33), IRS2(13), IRS4(28), JAK1(22), JAK2(14), JAK3(18), LEP(3), LEPR(18), MAPK10(7), MAPK8(7), MAPK9(7), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NPY(2), PCK1(14), PCK2(12), POMC(11), PPARA(8), PPARGC1A(16), PRKAA1(9), PRKAA2(11), PRKAB1(13), PRKAB2(6), PRKAG1(6), PRKAG2(8), PRKAG3(8), PRKCQ(18), PTPN11(10), RELA(7), RXRA(13), RXRB(5), RXRG(7), SLC2A1(9), SLC2A4(5), SOCS3(4), STAT3(9), STK11(11), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF2(5), TYK2(15) 71403572 686 245 659 203 201 90 69 152 166 8 0.0426 1.000 1.000 242 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(5), AGT(5), AKT1(7), CALM1(2), CALM2(3), CALM3(2), CALR(4), CAMK1(4), CAMK1G(10), CAMK4(10), CREBBP(59), CSNK1A1(7), EDN1(4), ELSPBP1(3), F2(15), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(9), HAND1(5), HAND2(7), HRAS(2), IGF1(3), LIF(4), MAP2K1(9), MAPK1(4), MAPK14(3), MAPK3(3), MAPK8(7), MEF2C(7), MYH2(49), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NKX2-5(10), NPPA(2), PIK3CA(101), PIK3R1(17), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RAF1(11), RPS6KB1(6), SYT1(8) 43476896 569 245 485 136 160 92 82 110 124 1 1.49e-06 1.000 1.000 243 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(7), APC(68), AR(29), ASAH1(4), BRAF(22), CAMP(3), CCL13(1), CCL15(2), CCL16(3), DAG1(14), EGFR(24), GNA11(6), GNA15(6), GNAI1(4), GNAQ(4), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), KCNJ3(18), KCNJ5(8), KCNJ9(5), MAPK1(4), MAPK10(7), MAPK14(3), PHKA2(18), PIK3CA(101), PIK3CD(20), PIK3R1(17), PITX2(6), PTX3(4), RAF1(11), SRC(5) 45799957 573 244 490 157 142 87 95 130 111 8 0.00203 1.000 1.000 244 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(7), ASAH1(4), BRAF(22), CAMP(3), CREB1(4), CREB5(9), CREBBP(59), CRKL(2), DAG1(14), EGR1(14), EGR2(9), EGR3(9), EGR4(8), ELK1(6), FRS2(6), GNAQ(4), JUN(6), MAP1B(38), MAP2K4(12), MAP2K7(38), MAPK1(4), MAPK10(7), MAPK3(3), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), NTRK1(14), OPN1LW(10), PIK3C2G(18), PIK3CA(101), PIK3CD(20), PIK3R1(17), PTPN11(10), RPS6KA3(6), SHC1(7), SRC(5), TERF2IP(6), TH(10) 44178065 555 242 475 138 151 91 78 111 120 4 1.91e-05 1.000 1.000 245 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(7), AKT2(11), AKT3(10), BRAF(22), CAB39(2), EIF4B(5), EIF4EBP1(5), FIGF(5), HIF1A(10), IGF1(3), MAPK1(4), MAPK3(3), PDPK1(1), PGF(4), PIK3CA(101), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PRKAA1(9), PRKAA2(11), RHEB(3), RICTOR(31), RPS6(1), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA6(24), RPS6KB1(6), RPS6KB2(9), STK11(11), TSC1(20), TSC2(21), ULK1(23), ULK2(13), ULK3(5), VEGFB(2), VEGFC(17) 45853801 548 241 463 125 143 87 92 108 113 5 2.11e-05 1.000 1.000 246 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(5), AKT1(7), BDKRB2(3), CALM1(2), CALM2(3), CALM3(2), CAV1(6), CHRM1(8), CHRNA1(11), FLT1(26), FLT4(36), KDR(22), NOS3(20), PDE2A(19), PDE3A(26), PDE3B(26), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKG1(15), PRKG2(20), RYR2(141), SLC7A1(11), SYT1(8), TNNI1(1) 35135897 462 241 433 147 125 58 55 124 99 1 0.165 1.000 1.000 247 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(5), CDC40(12), CLK2(15), CLK3(14), CLK4(8), COL2A1(26), CPSF1(33), CPSF2(10), CPSF3(4), CPSF4(2), CSTF1(11), CSTF2(7), CSTF2T(14), CSTF3(10), DDIT3(5), DDX1(15), DDX20(4), DHX15(15), DHX16(10), DHX38(17), DHX8(24), DHX9(20), DICER1(16), DNAJC8(5), FUS(5), GIPC1(11), LSM7(1), METTL3(4), NCBP1(8), NCBP2(3), NONO(6), NUDT21(3), NXF1(5), PABPN1(5), PAPOLA(9), PHF5A(1), POLR2A(27), PPM1G(4), PRPF18(3), PRPF3(10), PRPF4(10), PRPF4B(15), PRPF8(23), PSKH1(8), PTBP1(13), PTBP2(4), RBM17(2), RBM5(11), RNGTT(5), RNMT(11), RNPS1(2), SF3A1(10), SF3A2(3), SF3A3(3), SF3B1(15), SF3B2(20), SF3B4(10), SNRPA(7), SNRPA1(5), SNRPB(2), SNRPB2(2), SNRPD1(2), SNRPD2(6), SNRPD3(4), SNRPE(2), SNRPF(1), SNRPG(1), SNRPN(14), SNURF(1), SPOP(6), SRPK1(11), SRPK2(10), SRRM1(17), SUPT5H(19), TXNL4A(1), U2AF1(5), U2AF2(16), XRN2(16) 91211851 720 236 689 165 207 97 98 132 184 2 0.000668 1.000 1.000 248 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(6), ATP8A1(18), AVPR1A(20), AVPR1B(3), AVPR2(12), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(13), CCKAR(8), CCKBR(19), CCR1(8), CCR10(4), CCR2(6), CCR3(14), CCR4(3), CCR5(5), CCR6(2), CCR7(5), CCR8(4), CX3CR1(7), CXCR3(3), CXCR4(1), CXCR6(2), EDNRA(5), EDNRB(36), FPR1(9), FSHR(30), GALR1(8), GALR2(14), GALR3(5), GALT(3), GHSR(10), GNB2L1(5), GNRHR(5), GRPR(7), LHCGR(24), MC1R(8), MC2R(4), MC3R(12), MC4R(11), MC5R(6), NMBR(3), NPY1R(6), NPY2R(8), NPY5R(5), NTSR1(11), NTSR2(7), OPRD1(5), OPRK1(19), OPRL1(11), OPRM1(9), OXTR(9), SSTR1(12), SSTR2(4), SSTR3(11), SSTR4(18), TAC4(4), TACR1(4), TACR2(2), TACR3(18), TRHR(7), TSHR(15) 44489794 564 236 531 208 187 62 85 135 94 1 0.270 1.000 1.000 249 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(12), APH1A(2), CREBBP(59), CTBP1(5), CTBP2(10), DLL1(17), DLL3(9), DLL4(5), DTX1(21), DTX2(9), DTX3(7), DTX3L(4), DTX4(14), DVL1(8), DVL2(11), DVL3(17), EP300(39), HDAC1(10), HDAC2(6), HES1(2), JAG1(18), JAG2(21), LFNG(4), MAML1(8), MAML2(18), MAML3(13), MFNG(1), NCOR2(52), NCSTN(13), NOTCH1(51), NOTCH2(39), NOTCH3(39), NOTCH4(29), NUMB(8), NUMBL(8), PSEN1(7), PSEN2(4), PSENEN(2), PTCRA(2), RBPJ(8), RBPJL(15), RFNG(3), SNW1(8) 60244758 638 235 612 220 192 78 72 129 162 5 0.319 1.000 1.000 250 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(13), ADCY6(19), ADCY8(48), CACNA1A(47), CACNA1B(38), GNAS(54), GNAT3(5), GNB1(2), GNB3(2), GNG13(3), GRM4(22), ITPR3(46), KCNB1(17), PDE1A(10), PLCB2(9), PRKACA(9), PRKACB(6), PRKACG(9), PRKX(6), SCNN1A(6), SCNN1B(10), SCNN1G(11), TAS1R1(11), TAS1R2(18), TAS1R3(14), TAS2R1(4), TAS2R10(5), TAS2R13(6), TAS2R14(7), TAS2R16(8), TAS2R3(4), TAS2R38(6), TAS2R39(4), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(6), TAS2R43(3), TAS2R46(5), TAS2R5(2), TAS2R50(3), TAS2R60(6), TAS2R7(5), TAS2R8(5), TAS2R9(3), TRPM5(9) 49354363 536 235 509 187 183 63 60 132 97 1 0.408 1.000 1.000 251 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(12), ACTB(10), ACTG1(2), ARHGEF2(18), ARPC5(1), ARPC5L(3), CD14(2), CDC42(3), CDH1(34), CLDN1(4), CTNNB1(36), CTTN(13), EZR(6), FYN(10), HCLS1(4), ITGB1(12), KRT18(5), LY96(5), NCK1(7), NCK2(10), NCL(12), OCLN(10), PRKCA(9), RHOA(23), ROCK1(22), ROCK2(20), TLR4(33), TLR5(11), TUBA1A(5), TUBA1B(3), TUBA1C(4), TUBA3C(17), TUBA3D(12), TUBA3E(11), TUBA4A(3), TUBA8(11), TUBAL3(8), TUBB(1), TUBB1(9), TUBB2A(7), TUBB2B(5), TUBB3(12), TUBB6(9), TUBB8(10), WAS(4), WASL(7), YWHAQ(5), YWHAZ(4) 45323664 484 233 447 124 110 76 61 142 93 2 0.000712 1.000 1.000 252 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(12), ACTB(10), ACTG1(2), ARHGEF2(18), ARPC5(1), ARPC5L(3), CD14(2), CDC42(3), CDH1(34), CLDN1(4), CTNNB1(36), CTTN(13), EZR(6), FYN(10), HCLS1(4), ITGB1(12), KRT18(5), LY96(5), NCK1(7), NCK2(10), NCL(12), OCLN(10), PRKCA(9), RHOA(23), ROCK1(22), ROCK2(20), TLR4(33), TLR5(11), TUBA1A(5), TUBA1B(3), TUBA1C(4), TUBA3C(17), TUBA3D(12), TUBA3E(11), TUBA4A(3), TUBA8(11), TUBAL3(8), TUBB(1), TUBB1(9), TUBB2A(7), TUBB2B(5), TUBB3(12), TUBB6(9), TUBB8(10), WAS(4), WASL(7), YWHAQ(5), YWHAZ(4) 45323664 484 233 447 124 110 76 61 142 93 2 0.000712 1.000 1.000 253 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(7), AKT2(11), AKT3(10), BAD(4), BCR(18), BLNK(8), BTK(5), CD19(5), CSK(10), DAG1(14), EPHB2(19), GRB2(4), ITPKA(2), ITPKB(20), LYN(9), MAP2K1(9), MAP2K2(6), MAPK1(4), NFAT5(17), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PI3(2), PIK3CA(101), PIK3CD(20), PIK3R1(17), PLCG2(22), PPP1R13B(19), RAF1(11), SERPINA4(9), SHC1(7), SOS1(12), SOS2(19), SYK(11), VAV1(21) 45582906 489 232 409 122 130 83 63 115 96 2 0.000274 1.000 1.000 254 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(18), AMY2A(9), AMY2B(23), ENPP1(12), ENPP3(16), GAA(11), GANAB(21), GBE1(10), GCK(10), GPI(6), GUSB(12), GYS1(10), GYS2(11), HK1(18), HK2(15), HK3(13), MGAM(28), PGM1(4), PGM3(13), PYGB(17), PYGL(14), PYGM(18), RNPC3(5), SI(49), UCHL1(3), UCHL3(4), UGDH(11), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2B15(6), UGT2B4(6), UXS1(9) 49275365 453 230 426 138 100 57 58 138 99 1 0.262 1.000 1.000 255 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(3), AKT1(7), ANGPTL2(9), DAG1(14), DGKA(12), ETFA(3), GCA(3), ITGA9(11), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), MAP2K1(9), MAPK1(4), MAPK3(3), NR1I3(3), PAK1(7), PDE3A(26), PDE3B(26), PI3(2), PIK3C2G(18), PIK3CA(101), PIK3CD(20), PIK3R1(17), PSME1(4), RIPK3(5), RPS4X(2), SGCB(6), VASP(2) 41927616 468 229 395 124 112 83 78 105 86 4 0.000451 1.000 1.000 256 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(5), CRK(2), CRKL(2), DOCK1(29), ELK1(6), FOS(2), GAB1(5), GRB2(4), HGF(22), HRAS(2), ITGA1(10), ITGB1(12), JUN(6), MAP2K1(9), MAP2K2(6), MAP4K1(4), MAPK1(4), MAPK3(3), MAPK8(7), MET(14), PAK1(7), PIK3CA(101), PIK3R1(17), PTEN(43), PTK2(12), PTK2B(20), PTPN11(10), PXN(9), RAF1(11), RAP1A(4), RAP1B(6), RASA1(28), SOS1(12), SRC(5), STAT3(9) 38405585 448 227 361 94 84 80 67 107 104 6 9.14e-06 1.000 1.000 257 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(11), CD28(2), CSK(10), CTLA4(4), DAG1(14), DTYMK(2), EPHB2(19), FBXW7(46), GRAP2(9), GRB2(4), ITK(12), ITPKA(2), ITPKB(20), LAT(3), LCK(5), LCP2(14), MAPK1(4), NCK1(7), NFAT5(17), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PLCG1(27), PTPRC(30), RAF1(11), RASGRP1(11), RASGRP2(9), RASGRP3(8), RASGRP4(8), SOS1(12), SOS2(19), VAV1(21), ZAP70(16) 48438632 482 227 449 132 146 49 45 129 111 2 0.0477 1.000 1.000 258 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM2(3), CALM3(2), CD3E(3), ELK1(6), FOS(2), FYN(10), GRB2(4), HRAS(2), JUN(6), LAT(3), LCK(5), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK3(3), MAPK8(7), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB1(10), NFKBIA(1), PIK3CA(101), PIK3R1(17), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKCA(9), PTPN7(8), RAC1(2), RAF1(11), RASA1(28), RELA(7), SHC1(7), SOS1(12), SYT1(8), VAV1(21), ZAP70(16) 41110116 498 226 417 89 131 86 64 101 113 3 1.52e-10 1.000 1.000 259 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(7), AK3(7), CAD(31), CANT1(5), CTPS2(3), DCK(5), DCTD(2), DHODH(7), DPYD(25), DPYS(12), DTYMK(2), DUT(3), ENTPD1(6), ENTPD3(6), ENTPD4(14), ENTPD5(5), ENTPD6(7), ENTPD8(7), ITPA(1), NME2(3), NME4(2), NME6(4), NME7(4), NT5C1A(9), NT5C1B(14), NT5C2(9), NT5E(5), NT5M(7), NUDT2(5), PNPT1(6), POLA1(8), POLA2(6), POLD1(18), POLD2(8), POLD3(7), POLE(42), POLE2(6), POLE3(4), POLE4(1), POLR1A(23), POLR1B(11), POLR1C(9), POLR1D(4), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLR3A(31), POLR3B(16), POLR3G(3), POLR3H(2), POLR3K(2), PRIM1(6), PRIM2(10), RFC5(3), RRM1(5), RRM2(3), RRM2B(5), TK1(1), TK2(4), TXNRD1(13), TXNRD2(6), TYMS(3), UCK1(7), UCK2(2), UMPS(6), UPB1(6), UPP1(4), UPP2(8), UPRT(6), ZNRD1(2) 70044240 583 225 563 169 171 68 77 134 133 0 0.0357 1.000 1.000 260 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(6), ADAM17(12), ATP6AP1(6), ATP6V0A1(9), ATP6V0A2(11), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V0D2(6), ATP6V0E1(1), ATP6V1A(7), ATP6V1B1(25), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), CASP3(2), CCL5(4), CDC42(3), CHUK(10), CSK(10), CXCL1(1), EGFR(24), F11R(2), GIT1(4), HBEGF(2), IGSF5(5), IKBKB(12), JAM2(2), JAM3(7), JUN(6), LYN(9), MAP2K4(12), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK8(7), MAPK9(7), MET(14), NFKB1(10), NFKB2(11), NFKBIA(1), NOD1(17), PAK1(7), PLCG1(27), PLCG2(22), PTPN11(10), PTPRZ1(40), RAC1(2), RELA(7), SRC(5), TCIRG1(7), TJP1(32) 60500437 526 225 502 148 120 77 56 136 134 3 0.0661 1.000 1.000 261 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(4), AKT1(7), AKT2(11), AKT3(10), BAD(4), BTK(5), CDKN2A(36), DAPP1(2), GRB2(4), GSK3A(6), GSK3B(9), IARS(15), IGFBP1(11), INPP5D(12), PDK1(3), PIK3CA(101), PPP1R13B(19), PTEN(43), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SOS1(12), SOS2(19), TEC(5), YWHAB(3), YWHAE(5), YWHAG(4), YWHAH(3), YWHAQ(5), YWHAZ(4) 30950494 405 225 323 84 77 79 57 86 101 5 5.36e-05 1.000 1.000 262 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(11), ARHGDIB(1), BAG4(5), BCL2(4), BID(3), BIRC2(8), BIRC3(12), CASP2(5), CASP3(2), CASP6(2), CASP7(5), CASP8(24), CASP9(4), CFLAR(3), CHUK(10), CRADD(7), DAXX(14), DFFA(5), DFFB(5), FADD(4), GSN(15), LMNA(13), LMNB1(5), LMNB2(11), MAP2K7(38), MAP3K1(24), MAP3K5(18), MAPK8(7), MDM2(10), NFKB1(10), NFKBIA(1), NUMA1(31), PAK2(13), PRKCD(12), PRKDC(70), PSEN1(7), PSEN2(4), PTK2(12), RASA1(28), RB1(22), RELA(7), RIPK1(5), SPTAN1(30), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF1(6), TRAF2(5) 59701217 555 222 530 148 145 68 78 103 155 6 0.0288 1.000 1.000 263 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(8), INPP1(4), INPP4A(12), INPP4B(15), INPP5A(11), INPPL1(29), ITPKA(2), ITPKB(20), MIOX(8), OCRL(10), PIK3C2A(20), PIK3C2B(25), PIK3C2G(18), PIK3CA(101), PIK3CB(17), PIK3CG(25), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCG1(27), PLCG2(22) 38728991 457 217 376 89 115 88 74 95 83 2 1.75e-07 1.000 1.000 264 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(7), AKT2(11), AKT3(10), ANKRD6(11), APC(68), AXIN1(17), AXIN2(22), CER1(4), CSNK1A1(7), CTNNB1(36), DACT1(12), DKK1(12), DKK2(11), DKK3(5), DKK4(7), DVL1(8), FSTL1(6), GSK3A(6), GSK3B(9), LRP1(62), MVP(14), NKD1(8), NKD2(7), PIN1(2), PSEN1(7), PTPRA(19), SENP2(10), SFRP1(9), TSHB(5), WIF1(5) 34783117 417 217 384 112 111 50 50 91 106 9 0.0424 1.000 1.000 265 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(6), APC(68), ATF2(4), AXIN1(17), BMP10(7), BMP2(8), BMP4(6), BMP5(12), BMP7(9), BMPR1A(13), BMPR2(24), CHRD(15), CTNNB1(36), DVL1(8), FZD1(15), GATA4(4), GSK3B(9), MAP3K7(14), MEF2C(7), MYL2(9), NKX2-5(10), NOG(3), NPPA(2), NPPB(3), RFC1(19), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TGFBR2(32), TGFBR3(12), WNT1(11) 31117397 417 216 380 104 88 42 49 90 140 8 0.0521 1.000 1.000 266 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), AOC2(14), AOC3(18), AOX1(18), CARM1(10), COMT(5), DBH(8), DCT(20), DDC(14), ECH1(5), ESCO1(13), ESCO2(11), FAH(9), GOT1(3), GOT2(2), GSTZ1(2), HEMK1(2), HGD(8), HPD(4), LCMT1(2), LCMT2(11), MAOA(6), MAOB(6), METTL2B(1), METTL6(5), MIF(2), NAT6(4), PNMT(11), PNPLA3(4), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), SH3GLB1(5), TAT(7), TH(10), TPO(35), TYR(18), TYRP1(10), WBSCR22(5) 51096131 432 206 402 113 107 46 40 107 128 4 0.0500 1.000 1.000 267 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(7), ALPL(10), ALPP(16), ALPPL2(6), ASCC3(41), ATP13A2(20), DDX18(17), DDX19A(8), DDX23(15), DDX4(12), DDX41(11), DDX47(2), DDX50(14), DDX51(11), DDX52(8), DDX54(18), DDX55(7), DDX56(11), DHX58(12), ENTPD7(11), EP400(55), ERCC2(11), ERCC3(9), FPGS(8), GCH1(1), GGH(2), IFIH1(13), MOV10L1(13), NUDT5(1), NUDT8(2), QDPR(6), RAD54B(5), RAD54L(5), RUVBL2(10), SETX(31), SKIV2L2(18), SMARCA2(39), SMARCA5(12), SPR(3) 54223988 501 204 484 156 145 56 59 122 117 2 0.319 1.000 1.000 268 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(7), AVP(5), CABIN1(28), CALM1(2), CALM2(3), CALM3(2), CAMK1(4), CAMK1G(10), HDAC5(15), IGF1(3), IGF1R(24), INSR(26), MAP2K6(1), MAPK14(3), MAPK7(9), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), MYOD1(8), NFATC1(20), NFATC2(32), PIK3CA(101), PIK3R1(17), PPP3CA(14), PPP3CB(8), PPP3CC(9), SYT1(8), YWHAH(3) 29900546 389 199 319 104 105 69 67 72 74 2 0.000249 1.000 1.000 269 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACADL(8), ACADM(7), ACOX1(7), ACOX2(10), ACOX3(14), ACSL1(6), ACSL3(10), ACSL4(7), ACSL5(8), ACSL6(10), ADIPOQ(5), ANGPTL4(5), APOA1(9), APOA5(9), APOC3(3), AQP7(9), CD36(7), CPT1A(16), CPT1B(13), CPT1C(12), CPT2(8), CYP27A1(8), CYP4A11(4), CYP4A22(7), CYP7A1(7), CYP8B1(7), DBI(1), EHHADH(5), FABP2(1), FABP3(1), FABP4(2), FABP5(2), FABP6(5), FABP7(1), FADS2(6), GK(5), GK2(13), HMGCS2(6), ILK(11), LPL(11), ME1(2), MMP1(4), NR1H3(5), OLR1(4), PCK1(14), PCK2(12), PDPK1(1), PLTP(8), PPARA(8), PPARD(8), PPARG(6), RXRA(13), RXRB(5), RXRG(7), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(10), SLC27A4(11), SLC27A5(6), SLC27A6(17), SORBS1(19), UBC(9), UCP1(5) 56233780 477 199 461 149 151 62 55 110 99 0 0.144 1.000 1.000 270 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(7), AKT2(11), AKT3(10), ASAH1(4), BRAF(22), DAG1(14), DRD2(14), EGFR(24), EPHB2(19), GRB2(4), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), KCNJ3(18), KCNJ5(8), KCNJ9(5), MAPK1(4), PI3(2), PIK3CB(17), PITX2(6), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), RAF1(11), RGS20(9), SHC1(7), SOS1(12), SOS2(19), SRC(5), STAT3(9), TERF2IP(6) 50405232 492 199 470 163 153 73 54 111 97 4 0.305 1.000 1.000 271 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), AGK(6), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AGPAT6(7), AKR1A1(6), AKR1B1(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), CEL(20), DAK(8), DGAT1(10), DGAT2(2), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKI(27), DGKQ(5), DGKZ(12), GK(5), GK2(13), GLA(3), GLB1(9), GPAM(12), LCT(32), LIPA(3), LIPC(5), LIPF(10), LIPG(5), LPL(11), MGLL(3), PNLIP(6), PNLIPRP1(5), PNPLA3(4), PPAP2A(5), PPAP2B(5), PPAP2C(6) 50605726 447 198 421 138 121 50 56 106 112 2 0.212 1.000 1.000 272 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(18), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AGPAT6(7), CDIPT(1), CDS1(6), CDS2(4), CHAT(14), CHKA(2), CHKB(4), CHPT1(4), CRLS1(1), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKI(27), DGKQ(5), DGKZ(12), ESCO1(13), ESCO2(11), ETNK1(5), ETNK2(4), GNPAT(5), GPAM(12), GPD1(8), GPD1L(4), GPD2(10), LCAT(5), LYPLA1(2), LYPLA2(2), NAT6(4), PCYT1A(11), PCYT1B(9), PEMT(1), PHOSPHO1(1), PISD(6), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLD1(26), PLD2(22), PNPLA3(4), PPAP2A(5), PPAP2B(5), PPAP2C(6), PTDSS1(8), PTDSS2(3), SH3GLB1(5) 56478178 448 198 427 121 136 45 55 104 106 2 0.0160 1.000 1.000 273 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(34), DIAPH1(16), FYN(10), GSN(15), HRAS(2), ITGA1(10), ITGB1(12), MAP2K1(9), MAPK1(4), MAPK3(3), MYL2(9), MYLK(31), PFN1(1), PIK3CA(101), PIK3R1(17), PTK2(12), PXN(9), RAF1(11), ROCK1(22), SHC1(7), SRC(5), TLN1(35) 32193926 375 197 302 68 88 73 65 78 64 7 3.80e-08 1.000 1.000 274 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(5), CDK5(3), CDK5R1(6), CFL1(2), CHN1(5), LIMK1(7), MAP3K1(24), MYL2(9), MYLK(31), NCF2(3), PAK1(7), PDGFRA(17), PIK3CA(101), PIK3R1(17), PLD1(26), PPP1R12B(17), RAC1(2), RALBP1(12), RPS6KB1(6), TRIO(51), VAV1(21), WASF1(11) 30045861 383 196 310 80 85 71 60 86 78 3 1.45e-05 1.000 1.000 275 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(65), B3GALT4(9), CDR1(7), DGKI(27), IL6ST(11), MRPL19(3), PIGK(5), RPL10(6), RPL11(3), RPL12(3), RPL13(1), RPL13A(5), RPL14(2), RPL15(1), RPL17(1), RPL18(1), RPL18A(2), RPL19(1), RPL22(9), RPL23(2), RPL24(2), RPL26(2), RPL27(1), RPL28(2), RPL29(2), RPL3(5), RPL30(1), RPL31(3), RPL32(1), RPL34(2), RPL35(1), RPL35A(1), RPL36(2), RPL37(1), RPL38(2), RPL3L(4), RPL4(3), RPL5(3), RPL6(4), RPL7A(8), RPL8(5), RPL9(4), RPLP0(5), RPLP1(2), RPLP2(2), RPS10(2), RPS11(3), RPS13(4), RPS14(3), RPS15(2), RPS16(1), RPS18(1), RPS19(3), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(2), RPS26(3), RPS27(1), RPS27A(4), RPS3(2), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(5), RPS6(1), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA6(24), RPS6KB1(6), RPS6KB2(9), RPS7(1), RPS9(3), RPSA(5), SLC36A2(7), TBC1D10C(10), TSPAN9(4), UBA52(2), UBB(2), UBC(9) 45328202 392 196 375 122 97 44 49 103 97 2 0.792 1.000 1.000 276 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(7), AKT2(11), AKT3(10), BAD(4), BCL2(4), GRB2(4), GSK3A(6), GSK3B(9), IL4R(10), IRS1(33), IRS2(13), JAK1(22), JAK3(18), MAP4K1(4), MAPK1(4), MAPK3(3), PDK1(3), PIK3CA(101), PIK3CD(20), PIK3R1(17), PPP1R13B(19), RAF1(11), SHC1(7), SOCS1(1), SOS1(12), SOS2(19), STAT6(10) 31472056 382 194 303 73 89 72 56 72 89 4 2.36e-06 1.000 1.000 277 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(12), ACTR2(2), ACTR3(3), AKT1(7), ANGPTL2(9), CDC42(3), CFL1(2), CFL2(1), FLNA(31), FLNC(48), FSCN1(7), FSCN2(2), FSCN3(15), GDI1(6), GDI2(7), LIMK1(7), MYH2(49), MYLK(31), MYLK2(9), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PFN1(1), PFN2(1), RHO(10), ROCK1(22), ROCK2(20), RPS4X(2), VASP(2), WASF1(11), WASL(7) 41319111 398 194 391 134 129 45 55 85 80 4 0.209 1.000 1.000 278 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(25), AR(29), ESR1(14), ESR2(10), ESRRA(4), HNF4A(10), NPM1(3), NR0B1(6), NR1D1(11), NR1D2(11), NR1H2(7), NR1H3(5), NR1I2(11), NR1I3(3), NR2C2(10), NR2E1(4), NR2F1(11), NR2F2(6), NR2F6(6), NR3C1(10), NR4A1(6), NR4A2(18), NR5A1(9), NR5A2(10), PGR(23), PPARA(8), PPARD(8), PPARG(6), RARA(4), RARB(11), RARG(3), ROR1(13), RORA(9), RORC(7), RXRA(13), RXRB(5), RXRG(7), THRA(13), THRB(5), VDR(6) 36010843 380 193 369 134 128 51 41 99 59 2 0.380 1.000 1.000 279 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(7), AKT2(11), AKT3(10), CISH(4), GRB2(4), IARS(15), IL13RA1(6), IL2RG(12), IL4(4), IL4R(10), INPP5D(12), JAK1(22), JAK2(14), JAK3(18), NR0B2(4), PI3(2), PIK3CA(101), PPP1R13B(19), RPS6KB1(6), SERPINA4(9), SHC1(7), SOS1(12), SOS2(19), SRC(5), STAT6(10), TYK2(15) 31836130 358 193 283 64 71 70 56 80 78 3 2.73e-06 1.000 1.000 280 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(18), ACSS2(20), ACYP1(2), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), AKR1A1(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH7A1(2), ALDH9A1(7), ALDOA(1), ALDOB(11), ALDOC(11), BPGM(5), DLAT(9), DLD(14), ENO1(4), ENO2(6), ENO3(4), FBP1(4), FBP2(8), G6PC2(1), GALM(4), GAPDH(5), GAPDHS(5), GCK(10), GPI(6), HK1(18), HK2(15), HK3(13), LDHA(7), LDHAL6A(4), LDHAL6B(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(16), PDHB(4), PFKL(9), PFKM(6), PFKP(23), PGAM1(1), PGAM2(5), PGAM4(2), PGK1(5), PGK2(4), PGM1(4), PGM3(13), PKLR(12), TPI1(3) 50158638 454 192 431 149 115 85 48 111 95 0 0.170 1.000 1.000 281 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(8), EIF1(2), EIF2B1(8), EIF2B2(5), EIF2B3(9), EIF2B4(12), EIF2B5(11), EIF2S1(3), EIF2S2(3), EIF2S3(3), ELAVL1(12), FLT1(26), FLT4(36), HIF1A(10), HRAS(2), KDR(22), NOS3(20), PIK3CA(101), PIK3R1(17), PLCG1(27), PRKCA(9), PTK2(12), PXN(9), SHC1(7), VHL(2) 29371404 376 192 303 64 89 70 65 83 68 1 2.59e-09 1.000 1.000 282 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(9), AASDHPPT(1), AASS(13), ACAT1(9), ACAT2(6), AKR1B10(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), BBOX1(6), DLST(6), DOT1L(23), ECHS1(3), EHHADH(5), EHMT1(24), EHMT2(23), GCDH(8), HADH(3), HADHA(7), HSD17B4(11), HSD3B7(9), NSD1(41), OGDH(13), OGDHL(25), PIPOX(4), PLOD1(12), PLOD2(18), PLOD3(21), RDH11(1), RDH12(3), RDH13(8), SETD1A(29), SETD7(3), SETDB1(20), SHMT1(4), SHMT2(13), SPCS1(2), SPCS3(3), SUV39H1(6), SUV39H2(2), TMLHE(6) 49781362 474 191 439 135 135 59 55 103 120 2 0.0598 1.000 1.000 283 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(36), ACACB(49), ACAT1(9), ACAT2(6), ACOT12(9), ACSS1(18), ACSS2(20), ACYP1(2), ACYP2(3), AKR1B1(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), DLAT(9), DLD(14), GLO1(3), GRHPR(4), HAGH(6), HAGHL(2), LDHA(7), LDHAL6A(4), LDHAL6B(7), LDHB(5), LDHC(1), LDHD(2), MDH1(5), MDH2(2), ME1(2), ME2(10), ME3(8), PC(19), PCK1(14), PCK2(12), PDHA1(1), PDHA2(16), PDHB(4), PKLR(12) 40085121 395 191 373 117 102 70 41 88 93 1 0.104 1.000 1.000 284 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(26), AKT1(7), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CREB1(4), GNAS(54), GRB2(4), HRAS(2), MAPK1(4), MAPK14(3), MAPK3(3), PIK3CA(101), PIK3R1(17), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), RAC1(2), RPS6KA1(10), RPS6KA5(9), SOS1(12) 25144429 338 190 266 70 95 65 50 67 58 3 2.24e-05 1.000 1.000 285 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(10), AKT1(7), APC(68), ASAH1(4), CAMP(3), CAV3(2), DAG1(14), DLG4(8), EPHB2(19), GNAI1(4), GNAQ(4), ITPR1(40), ITPR2(41), ITPR3(46), KCNJ3(18), KCNJ5(8), KCNJ9(5), MAPK1(4), PITX2(6), PTX3(4), RAC1(2), RHO(10), RYR1(81) 39451534 408 190 394 131 133 47 48 88 85 7 0.106 1.000 1.000 286 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(3), GHR(11), GRB2(4), HRAS(2), INSR(26), IRS1(33), JAK2(14), MAP2K1(9), MAPK1(4), MAPK3(3), PIK3CA(101), PIK3R1(17), PLCG1(27), PRKCA(9), PTPN6(6), RAF1(11), RPS6KA1(10), SHC1(7), SLC2A4(5), SOCS1(1), SOS1(12), SRF(5), STAT5A(13), STAT5B(15) 28496177 348 189 278 70 82 76 58 62 66 4 8.98e-07 1.000 1.000 287 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(9), AANAT(2), ACAT1(9), ACAT2(6), ACMSD(6), AFMID(5), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), AOC2(14), AOC3(18), AOX1(18), ASMT(9), CARM1(10), CAT(6), CYP1A1(10), CYP1A2(6), CYP1B1(4), DDC(14), ECHS1(3), EHHADH(5), GCDH(8), HAAO(1), HADH(3), HADHA(7), HEMK1(2), HSD17B4(11), INMT(4), KMO(7), KYNU(15), LCMT1(2), LCMT2(11), LNX1(7), MAOA(6), MAOB(6), METTL2B(1), METTL6(5), NFX1(8), OGDH(13), OGDHL(25), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), TDO2(10), TPH1(6), TPH2(12), WARS(5), WARS2(14), WBSCR22(5) 52132677 463 189 425 121 106 66 48 100 140 3 0.0276 1.000 1.000 288 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(71), BMPR1B(13), CCND2(2), CDK4(2), CDKN1B(1), DMC1(10), EGR1(14), ESR2(10), FSHR(30), GJA4(8), INHA(7), LHCGR(24), MLH1(10), MSH5(6), NCOR1(34), NR5A1(9), NRIP1(21), PGR(23), PRLR(8), PTGER2(8), SMPD1(8), VDR(6), ZP2(13) 29980066 338 189 321 69 73 49 41 88 82 5 0.000157 1.000 1.000 289 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(7), CAD(31), CANT1(5), CTPS2(3), DCK(5), DCTD(2), DHODH(7), DPYD(25), DPYS(12), DTYMK(2), DUT(3), ENTPD1(6), ITPA(1), NME2(3), NT5E(5), NT5M(7), NUDT2(5), POLB(8), POLD1(18), POLD2(8), POLE(42), POLG(10), POLL(4), POLQ(46), POLR1B(11), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLRMT(17), RRM1(5), RRM2(3), TK1(1), TK2(4), TXNRD1(13), TYMS(3), UCK1(7), UCK2(2), UMPS(6), UNG(2), UPB1(6), UPP1(4) 49474757 408 189 394 137 105 58 55 93 97 0 0.472 1.000 1.000 290 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ACAT1(9), ACAT2(6), ACMSD(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), AOC2(14), AOC3(18), AOX1(18), ASMT(9), CAT(6), CYP19A1(13), CYP1A1(10), CYP1A2(6), CYP2A13(15), CYP2A6(8), CYP2A7(9), CYP2B6(9), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2D6(15), CYP2E1(8), CYP2F1(13), CYP2J2(5), CYP3A4(3), CYP3A5(3), CYP3A7(5), CYP4B1(12), CYP51A1(13), DDC(14), ECHS1(3), EHHADH(5), GCDH(8), HAAO(1), HADHA(7), KMO(7), KYNU(15), MAOA(6), MAOB(6), SDS(5), TDO2(10), TPH1(6), WARS(5), WARS2(14) 47532073 455 188 421 112 118 57 40 108 130 2 0.00972 1.000 1.000 291 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(22), GABBR1(20), GPRC5A(3), GPRC5B(17), GPRC5C(12), GPRC5D(2), GRM1(52), GRM2(30), GRM3(31), GRM4(22), GRM5(42), GRM7(30), GRM8(38) 17920118 321 187 309 99 119 35 39 82 46 0 0.0313 1.000 1.000 292 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(27), CALR(4), CANX(4), CD4(11), CD74(5), CD8A(4), CD8B(2), CIITA(23), CREB1(4), CTSB(3), CTSS(5), HLA-A(23), HLA-B(36), HLA-C(11), HLA-DMA(1), HLA-DMB(7), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(3), HLA-DPB1(5), HLA-DQA2(7), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(2), HLA-DRB5(3), HLA-E(7), HLA-F(8), HLA-G(7), HSP90AA1(15), HSP90AB1(13), HSPA5(4), IFI30(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), KIR2DL3(9), KIR3DL1(13), KIR3DL2(5), KLRC1(4), KLRC2(2), KLRC3(10), KLRC4(1), KLRD1(5), LGMN(7), LTA(4), NFYA(1), NFYB(3), NFYC(4), PDIA3(7), PSME1(4), PSME2(5), RFX5(17), RFXANK(7), RFXAP(4), TAP1(5), TAP2(11), TAPBP(8) 40143341 430 187 399 85 68 51 70 103 127 11 0.000171 1.000 1.000 293 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(18), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AGPS(10), CDIPT(1), CDS1(6), CDS2(4), CHAT(14), CHKA(2), CHKB(4), CLC(2), CPT1B(13), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKQ(5), DGKZ(12), ETNK1(5), GNPAT(5), GPD1(8), GPD2(10), LCAT(5), LYPLA1(2), LYPLA2(2), PAFAH1B1(16), PAFAH2(5), PCYT1A(11), PCYT1B(9), PEMT(1), PISD(6), PLA2G1B(8), PLA2G2A(2), PLA2G2E(4), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCB2(9), PLCG1(27), PLCG2(22), PPAP2A(5), PPAP2B(5), PPAP2C(6) 43177639 386 186 363 108 125 39 52 89 79 2 0.0280 1.000 1.000 294 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(17), ATP4A(24), ATP4B(5), ATP5A1(5), ATP5B(10), ATP5C1(7), ATP5F1(5), ATP5G2(2), ATP5G3(2), ATP5H(1), ATP5J(3), ATP5J2(1), ATP5L(1), ATP6AP1(6), ATP6V0A1(9), ATP6V0A2(11), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V0D2(6), ATP6V0E1(1), ATP6V1A(7), ATP6V1B1(25), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), COX10(2), COX15(5), COX4I1(4), COX4I2(3), COX5A(1), COX5B(1), COX6B1(2), COX6B2(1), COX6C(1), COX7A1(2), COX7B(3), COX7C(1), COX8A(1), COX8C(5), CYC1(5), LHPP(4), NDUFA1(2), NDUFA10(4), NDUFA12(2), NDUFA13(3), NDUFA3(1), NDUFA4(1), NDUFA7(1), NDUFA8(6), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(2), NDUFB11(2), NDUFB2(1), NDUFB3(3), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFB8(4), NDUFB9(2), NDUFC2(3), NDUFS1(8), NDUFS2(8), NDUFS3(4), NDUFS4(3), NDUFS5(3), NDUFS6(4), NDUFS7(4), NDUFS8(3), NDUFV1(6), NDUFV2(2), NDUFV3(2), PPA1(5), PPA2(4), SDHA(15), SDHB(4), SDHC(2), SDHD(3), TCIRG1(7), UQCRB(2), UQCRC1(3), UQCRC2(9), UQCRFS1(4), UQCRQ(2) 48177794 432 186 411 123 118 66 50 93 104 1 0.0343 1.000 1.000 295 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(5), ACTN1(8), ACTN2(34), BCAR1(16), BCR(18), CAPN1(8), CAPNS1(6), CAPNS2(3), CAV1(6), CRKL(2), CSK(10), FYN(10), GRB2(4), HRAS(2), ITGA1(10), ITGB1(12), JUN(6), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MAPK8(7), PPP1R12B(17), PTK2(12), PXN(9), RAF1(11), RAP1A(4), ROCK1(22), SHC1(7), SOS1(12), SRC(5), TLN1(35), VCL(19), ZYX(8) 40801788 350 186 334 105 129 41 34 87 57 2 0.0393 1.000 1.000 296 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(22), CARM1(10), CCND1(3), CREBBP(59), EP300(39), ERCC3(9), ESR1(14), GRIP1(24), GTF2A1(3), GTF2E1(7), GTF2F1(11), HDAC1(10), HDAC2(6), HDAC3(10), HDAC4(41), HDAC5(15), HDAC6(12), MEF2C(7), NCOR2(52), NR0B1(6), NRIP1(21), PELP1(11), POLR2A(27), TBP(8) 39703292 427 185 404 105 125 56 45 96 101 4 0.000841 1.000 1.000 297 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(6), B3GALNT1(5), B3GALT1(3), B3GALT2(10), B3GALT4(9), B3GALT5(2), B3GNT1(8), B3GNT2(6), B3GNT3(3), B3GNT4(9), B3GNT5(12), B4GALNT1(7), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT4(7), B4GALT6(9), FUT1(6), FUT2(2), FUT3(6), FUT4(3), FUT5(4), FUT6(8), FUT7(4), FUT9(11), GBGT1(4), GCNT2(1), PIGA(3), PIGB(11), PIGC(6), PIGG(16), PIGK(5), PIGL(5), PIGM(4), PIGN(12), PIGO(13), PIGP(1), PIGQ(14), PIGS(8), PIGT(15), PIGV(7), PIGX(3), PIGZ(11), ST3GAL1(7), ST3GAL2(11), ST3GAL3(3), ST3GAL4(8), ST3GAL5(3), ST3GAL6(7), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(11), ST6GALNAC6(5), ST8SIA1(12), ST8SIA5(8), UGCG(4) 41755154 387 185 363 129 114 40 42 98 92 1 0.623 1.000 1.000 298 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(35), COL4A2(24), COL4A3(19), COL4A4(25), COL4A5(26), COL4A6(15), F10(10), F11(9), F12(5), F2(15), F2R(10), F5(26), F8(36), F9(10), FGA(16), FGB(9), FGG(6), KLKB1(7), PROC(5), PROS1(16), SERPINC1(5), SERPING1(10) 38254445 339 185 332 92 74 56 39 100 68 2 0.0253 1.000 1.000 299 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(7), AKT2(11), AKT3(10), ARHGEF11(26), BCL2(4), CDC42(3), DLG4(8), GNA13(10), LPA(31), MAP2K4(12), MAP3K1(24), MAP3K5(18), MAPK8(7), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(18), PI3(2), PIK3CB(17), PLD1(26), PLD2(22), PLD3(9), PTK2(12), RDX(13), ROCK1(22), ROCK2(20), SERPINA4(9), SRF(5), TBXA2R(11) 42447796 396 183 375 95 101 58 48 70 114 5 0.00467 1.000 1.000 300 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(7), BAD(4), BCL2(4), BCL2L1(2), CBL(11), CFLAR(3), CRKL(2), E2F1(6), FOS(2), GRB2(4), HRAS(2), IL2RA(3), IL2RB(3), IL2RG(12), IRS1(33), JAK1(22), JAK3(18), MAPK1(4), MAPK3(3), MYC(6), NMI(2), PIK3CA(101), PIK3R1(17), PTPN6(6), RAF1(11), RPS6KB1(6), SHC1(7), SOCS1(1), SOCS3(4), SOS1(12), STAT5A(13), STAT5B(15), SYK(11) 31270580 357 182 282 76 68 73 60 75 77 4 6.09e-05 1.000 1.000 301 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 BCL2(4), CEBPA(2), CHUK(10), DAXX(14), EGF(15), EGFR(24), ETS1(9), ETS2(4), FOS(2), HOXA7(4), HRAS(2), IKBKB(12), JUN(6), MAP2K1(9), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP2K7(38), MAP3K1(24), MAP3K5(18), MAPK1(4), MAPK13(4), MAPK14(3), MAPK3(3), MAPK8(7), NFKB1(10), NFKBIA(1), PPP2CA(5), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCQ(18), RAF1(11), RELA(7), RIPK1(5), SP1(6), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRAF2(5) 42301444 388 181 372 115 126 54 44 77 83 4 0.0137 1.000 1.000 302 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(26), ADRA1B(6), ADRA1D(9), ADRA2A(12), ADRA2C(6), ADRB1(10), ADRB2(9), ADRB3(6), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), DRD1(7), DRD2(14), DRD3(9), DRD4(6), DRD5(13), HRH1(7), HRH2(9), HTR1A(18), HTR1B(11), HTR1D(9), HTR1E(18), HTR1F(10), HTR2A(12), HTR2B(5), HTR2C(11), HTR4(5), HTR5A(14), HTR6(7), HTR7(17) 21986477 350 180 330 117 127 41 47 94 41 0 0.0250 1.000 1.000 303 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(19), EEF1A2(8), EEF1B2(4), EEF1D(3), EEF1G(5), EEF2(22), EEF2K(15), EIF1AX(2), EIF1AY(2), EIF2AK1(7), EIF2AK2(6), EIF2AK3(22), EIF2B1(8), EIF2B2(5), EIF2B3(9), EIF2B4(12), EIF2B5(11), EIF2S1(3), EIF2S2(3), EIF2S3(3), EIF4A1(4), EIF4A2(8), EIF4E(2), EIF4EBP1(5), EIF4EBP2(7), EIF4G1(31), EIF4G3(26), EIF5(6), EIF5A(5), EIF5B(34), ETF1(7), GSPT2(9), PABPC1(12), PABPC3(20), PAIP1(4), SLC35A4(9) 37835112 358 179 337 74 80 47 52 88 88 3 0.000298 1.000 1.000 304 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(5), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH4A1(8), ALDH9A1(7), AMD1(8), AOC2(14), AOC3(18), ARG1(3), ARG2(4), ASL(8), CKB(7), CKM(2), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(35), DAO(15), GAMT(2), GATM(5), GLUD1(5), GOT1(3), GOT2(2), MAOA(6), MAOB(6), NOS1(45), NOS3(20), OAT(6), ODC1(4), OTC(5), P4HA1(6), P4HA2(11), P4HA3(7), P4HB(5), PYCR1(3), RARS(9), SMS(6) 38087168 380 178 355 99 103 40 48 93 96 0 0.0297 1.000 1.000 305 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(8), CASP3(2), CASP6(2), CASP7(5), CASP8(24), CFLAR(3), DAXX(14), DFFA(5), DFFB(5), FADD(4), FAF1(13), JUN(6), LMNA(13), LMNB1(5), LMNB2(11), MAP2K4(12), MAP3K1(24), MAP3K7(14), MAPK8(7), PAK1(7), PAK2(13), PRKDC(70), PTPN13(41), RB1(22), RIPK2(3), SPTAN1(30) 35540615 364 178 347 96 68 39 56 76 123 2 0.201 1.000 1.000 306 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(2), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), AKR1A1(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH9A1(7), ALDOA(1), ALDOB(11), ALDOC(11), BPGM(5), DLAT(9), DLD(14), ENO1(4), ENO2(6), ENO3(4), FBP1(4), FBP2(8), GAPDH(5), GCK(10), GPI(6), HK1(18), HK2(15), HK3(13), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(16), PDHB(4), PFKM(6), PFKP(23), PGAM1(1), PGK1(5), PGM1(4), PGM3(13), PKLR(12), TPI1(3) 42083253 388 178 367 125 97 62 42 100 87 0 0.243 1.000 1.000 307 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(2), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), AKR1A1(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH9A1(7), ALDOA(1), ALDOB(11), ALDOC(11), BPGM(5), DLAT(9), DLD(14), ENO1(4), ENO2(6), ENO3(4), FBP1(4), FBP2(8), GAPDH(5), GCK(10), GPI(6), HK1(18), HK2(15), HK3(13), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(16), PDHB(4), PFKM(6), PFKP(23), PGAM1(1), PGK1(5), PGM1(4), PGM3(13), PKLR(12), TPI1(3) 42083253 388 178 367 125 97 62 42 100 87 0 0.243 1.000 1.000 308 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AKR1A1(6), AKR1B1(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), CEL(20), DGAT1(10), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKQ(5), DGKZ(12), GK(5), GLA(3), GLB1(9), LCT(32), LIPC(5), LIPF(10), LIPG(5), LPL(11), PNLIP(6), PNLIPRP1(5), PPAP2A(5), PPAP2B(5), PPAP2C(6) 41603781 375 177 352 120 103 38 48 87 97 2 0.370 1.000 1.000 309 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(26), CALM1(2), CALM2(3), CALM3(2), CREB1(4), ELK1(6), FOS(2), GNAI1(4), GNAQ(4), GNAS(54), GNB1(2), GNGT1(4), HRAS(2), JUN(6), MAP2K1(9), MAPK3(3), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), RAF1(11), RPS6KA3(6), SYT1(8) 30034645 348 177 326 86 131 46 29 66 75 1 0.000770 1.000 1.000 310 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(5), AGXT2(13), AKR1B10(6), ALAS1(5), ALAS2(16), AMT(5), AOC2(14), AOC3(18), BHMT(8), CBS(9), CHDH(7), CHKA(2), CHKB(4), CTH(3), DAO(15), DLD(14), DMGDH(8), GAMT(2), GARS(6), GATM(5), GCAT(5), GLDC(11), GNMT(4), HSD3B7(9), MAOA(6), MAOB(6), PEMT(1), PHGDH(6), PIPOX(4), PISD(6), PSAT1(10), PSPH(4), RDH11(1), RDH12(3), RDH13(8), SARDH(14), SARS(11), SARS2(10), SDS(5), SHMT1(4), SHMT2(13), TARS(17), TARS2(15) 37006284 338 174 327 99 97 44 43 79 74 1 0.0824 1.000 1.000 311 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(5), CASP2(5), CASP3(2), CASP8(24), CRADD(7), DFFA(5), DFFB(5), FADD(4), JUN(6), LMNA(13), LMNB1(5), LMNB2(11), MADD(25), MAP2K4(12), MAP3K1(24), MAP3K7(14), MAPK8(7), PAK1(7), PAK2(13), PRKDC(70), RB1(22), RIPK1(5), SPTAN1(30), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(5) 33643994 338 174 326 93 75 35 51 68 106 3 0.235 1.000 1.000 312 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), AOC2(14), AOC3(18), AOX1(18), COMT(5), DBH(8), DCT(20), DDC(14), FAH(9), GOT1(3), GOT2(2), GSTZ1(2), HGD(8), HPD(4), MAOA(6), MAOB(6), PNMT(11), TAT(7), TH(10), TPO(35), TYR(18) 27369648 291 174 268 84 79 28 26 76 79 3 0.164 1.000 1.000 313 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(11), BAD(4), BAX(3), BCL2(4), BCL2A1(1), BCL2L1(2), BCL2L2(5), BOK(2), CASP1(8), CASP10(8), CASP2(5), CASP3(2), CASP4(7), CASP6(2), CASP7(5), CASP8(24), CASP9(4), CD40(3), CD40LG(6), CRADD(7), DAXX(14), DFFA(5), DFFB(5), FADD(4), FAS(3), FASLG(6), IKBKE(14), LTA(4), MCL1(3), NFKB1(10), NFKBIA(1), NGFR(9), NR3C1(10), NTRK1(14), PTPN13(41), RIPK1(5), TFG(2), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF1(6), TRAF2(5), TRAF3(8), TRAF6(7) 37452525 304 173 293 90 77 38 37 77 74 1 0.130 1.000 1.000 314 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(10), AARS2(21), CARS(11), CARS2(9), DARS(2), DARS2(6), EARS2(4), EPRS(21), FARS2(9), FARSA(8), FARSB(4), GARS(6), HARS(10), HARS2(5), IARS(15), IARS2(13), KARS(9), LARS(13), LARS2(12), MARS(10), MARS2(6), MTFMT(3), NARS(5), NARS2(4), QARS(10), RARS(9), RARS2(7), SARS(11), SARS2(10), TARS(17), TARS2(15), VARS(25), VARS2(16), WARS(5), WARS2(14), YARS(9), YARS2(4) 46619115 368 172 357 99 99 43 55 95 75 1 0.0876 1.000 1.000 315 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(12), ADCY3(21), ADCY9(23), AK1(1), ARF1(6), ARF4(2), ARF5(1), ARF6(2), ARL4D(1), ATP6V0A1(9), ATP6V0A2(11), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V0D2(6), ATP6V0E1(1), ATP6V1A(7), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), ERO1L(2), GNAS(54), PDIA4(9), PLCG1(27), PLCG2(22), PRKCA(9), SEC61A1(7), SEC61A2(5), SEC61B(1), SEC61G(1), TRIM23(11) 31895157 334 172 313 81 124 39 35 76 60 0 0.00128 1.000 1.000 316 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(5), AGXT2(13), ALAS1(5), ALAS2(16), AMT(5), AOC2(14), AOC3(18), ATP6V0C(2), BHMT(8), CBS(9), CHDH(7), CHKA(2), CHKB(4), CPT1B(13), CTH(3), DAO(15), DLD(14), DMGDH(8), GAMT(2), GARS(6), GATM(5), GCAT(5), GLDC(11), MAOA(6), MAOB(6), PEMT(1), PISD(6), PLCB2(9), PLCG1(27), PLCG2(22), PSPH(4), SARDH(14), SARS(11), SHMT1(4), SHMT2(13), TARS(17) 36301077 330 171 318 95 96 41 38 79 76 0 0.0711 1.000 1.000 317 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(26), AKT1(7), BAD(4), BAX(3), BCL2(4), BCL2L1(2), CSF2RB(18), IGF1(3), IGF1R(24), IL3(3), IL3RA(6), KIT(20), KITLG(6), PIK3CA(101), PIK3R1(17), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), YWHAH(3) 18902104 291 170 228 80 61 65 58 56 49 2 0.00294 1.000 1.000 318 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(8), BTK(5), CALM1(2), CALM2(3), CALM3(2), CD79A(10), CD79B(3), ELK1(6), FOS(2), GRB2(4), HRAS(2), JUN(6), LYN(9), MAP2K1(9), MAP3K1(24), MAPK14(3), MAPK3(3), MAPK8(7), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKCA(9), RAC1(2), RAF1(11), SHC1(7), SOS1(12), SYK(11), SYT1(8), VAV1(21) 32820852 326 170 304 73 109 45 30 68 74 0 0.000169 1.000 1.000 319 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(3), ACAA2(13), ACADM(7), ACADS(6), ACAT1(9), ACAT2(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH6A1(8), ALDH7A1(2), ALDH9A1(7), AOX1(18), AUH(7), BCAT1(6), BCAT2(11), BCKDHA(14), BCKDHB(6), DBT(6), DLD(14), ECHS1(3), EHHADH(5), HADH(3), HADHA(7), HADHB(6), HIBADH(3), HIBCH(6), HMGCS1(2), HMGCS2(6), HSD17B4(11), IVD(5), MCCC1(5), MCCC2(10), MCEE(6), MUT(10), OXCT1(10), OXCT2(7), PCCA(15), PCCB(6) 37084522 332 170 306 82 69 54 35 72 101 1 0.0268 1.000 1.000 320 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(10), AARS2(21), ABAT(4), ACY3(3), ADSL(8), ADSS(6), ADSSL1(10), AGXT(5), AGXT2(13), ASL(8), ASNS(10), ASPA(4), ASRGL1(6), ASS1(11), CAD(31), CRAT(14), DARS(2), DARS2(6), DDO(7), DLAT(9), DLD(14), GAD1(11), GAD2(17), GOT1(3), GOT2(2), GPT(8), GPT2(4), NARS(5), NARS2(4), PC(19), PDHA1(1), PDHA2(16), PDHB(4) 32655189 296 169 281 89 89 40 35 66 65 1 0.165 1.000 1.000 321 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), AKR1C1(3), AKR1C2(2), AKR1C3(3), AKR1C4(7), ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), CYP1A1(10), CYP1A2(6), CYP1B1(4), CYP2B6(9), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2E1(8), CYP2F1(13), CYP2S1(9), CYP3A4(3), CYP3A43(6), CYP3A5(3), CYP3A7(5), DHDH(5), EPHX1(13), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(3), GSTK1(3), GSTM2(1), GSTM3(3), GSTM4(3), GSTM5(3), GSTO2(4), GSTP1(2), GSTZ1(2), MGST1(3), MGST2(3), MGST3(5), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7) 49316669 365 169 346 97 81 43 47 99 95 0 0.0715 1.000 1.000 322 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(7), GTF2E2(4), GTF2F1(11), GTF2F2(3), GTF2H1(6), GTF2H3(4), GTF2H4(9), GTF2I(6), GTF2IRD1(19), STON1(10), TAF1(32), TAF10(2), TAF13(1), TAF1L(45), TAF2(15), TAF4(16), TAF4B(10), TAF5(4), TAF5L(12), TAF6(15), TAF6L(9), TAF7(8), TAF7L(10), TAF9B(5), TBPL1(4), TBPL2(7) 30995493 286 168 276 70 63 39 38 75 71 0 0.0407 1.000 1.000 323 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(3), CALM3(2), CAMK1(4), CAMK1G(10), ELK1(6), FPR1(9), GNA15(6), GNB1(2), GNGT1(4), HRAS(2), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K6(1), MAP3K1(24), MAPK1(4), MAPK14(3), MAPK3(3), NCF1(4), NCF2(3), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB1(10), NFKBIA(1), PAK1(7), PIK3C2G(18), PLCB1(24), PPP3CA(14), PPP3CB(8), PPP3CC(9), RAC1(2), RAF1(11), RELA(7), SYT1(8) 33066035 316 167 300 95 93 44 36 65 78 0 0.0960 1.000 1.000 324 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(26), AKT1(7), ASAH1(4), GNAI1(4), GNB1(2), GNGT1(4), ITGAV(23), ITGB3(8), MAPK1(4), MAPK3(3), PDGFA(4), PDGFRA(17), PIK3CA(101), PIK3R1(17), PLCB1(24), PRKCA(9), PTK2(12), RAC1(2), SMPD1(8), SMPD2(3), SPHK1(10), SRC(5) 23576846 297 165 229 64 65 62 58 50 60 2 3.74e-05 1.000 1.000 325 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(5), AGTR2(6), CALM1(2), CALM2(3), CALM3(2), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CDK5(3), F2(15), FYN(10), GNA11(6), GNAI1(4), GNB1(2), GNGT1(4), GRB2(4), HRAS(2), JAK2(14), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK14(3), MAPK3(3), MAPK8(7), MAPT(12), MYLK(31), PLCG1(27), PRKCA(9), PTK2B(20), RAF1(11), SHC1(7), SOS1(12), STAT1(14), STAT3(9), STAT5A(13), SYT1(8) 36054148 314 164 304 94 98 42 32 82 58 2 0.0857 1.000 1.000 326 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(10), F11(9), F12(5), F13B(20), F2(15), F5(26), F7(12), F8(36), F9(10), FGA(16), FGB(9), FGG(6), LPA(31), PLAT(8), PLG(21), SERPINB2(11), SERPINE1(3), SERPINF2(10), VWF(47) 30271253 305 164 296 78 75 35 40 86 68 1 0.0336 1.000 1.000 327 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(11), ALOX15(12), ALOX5(15), CBR1(1), CBR3(4), CYP4F2(17), CYP4F3(14), EPX(18), GGT1(9), LPO(14), LTA4H(5), MPO(12), PLA2G1B(8), PLA2G2A(2), PLA2G2E(4), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PRDX1(3), PRDX2(3), PRDX6(5), PTGDS(3), PTGES2(6), PTGIS(10), PTGS1(15), PTGS2(7), TBXAS1(9), TPO(35) 24254995 277 164 262 73 98 29 22 80 45 3 0.0104 1.000 1.000 328 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACAA2(13), ACADL(8), ACADM(7), ACADS(6), ACADSB(9), ACADVL(5), ACAT1(9), ACAT2(6), ACOX1(7), ACOX3(14), ACSL1(6), ACSL3(10), ACSL4(7), ACSL5(8), ACSL6(10), ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), CPT1A(16), CPT1B(13), CPT1C(12), CPT2(8), CYP4A11(4), CYP4A22(7), ECHS1(3), EHHADH(5), GCDH(8), HADH(3), HADHA(7), HADHB(6), HSD17B4(11) 42069034 337 163 315 80 78 58 41 65 95 0 0.00179 1.000 1.000 329 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ALDH4A1(8), ALDH5A1(6), CAD(31), CPS1(35), EARS2(4), EPRS(21), GAD1(11), GAD2(17), GCLC(4), GCLM(4), GFPT1(9), GFPT2(9), GLS(13), GLS2(8), GLUD1(5), GLUD2(17), GLUL(7), GMPS(10), GNPNAT1(6), GOT1(3), GOT2(2), GPT(8), GPT2(4), GSR(8), GSS(2), NADSYN1(13), NAGK(2), PPAT(7), QARS(10) 34020030 288 163 279 86 68 38 39 81 62 0 0.186 1.000 1.000 330 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(24), ELK1(6), GNAS(54), GNB1(2), GNGT1(4), GRB2(4), HRAS(2), IGF1R(24), ITGB1(12), KLK2(2), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MKNK1(6), MKNK2(10), MYC(6), NGFR(9), PDGFRA(17), PPP2CA(5), PTPRR(16), RAF1(11), RPS6KA1(10), RPS6KA5(9), SHC1(7), SOS1(12), SRC(5), STAT3(9) 28722458 288 162 269 110 104 40 27 75 41 1 0.705 1.000 1.000 331 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(9), ALG10(17), ALG10B(11), ALG11(9), ALG12(13), ALG13(9), ALG14(3), ALG2(3), ALG3(4), ALG5(6), ALG6(6), ALG8(3), ALG9(3), B4GALT1(6), B4GALT2(9), B4GALT3(4), DDOST(1), DHDDS(2), DOLPP1(3), DPAGT1(6), DPM1(2), FUT8(11), GANAB(21), MAN1A1(6), MAN1A2(7), MAN1B1(8), MAN1C1(11), MAN2A1(10), MGAT1(6), MGAT2(4), MGAT3(13), MGAT4A(6), MGAT4B(6), MGAT5(14), MGAT5B(15), RFT1(5), RPN1(7), RPN2(9), ST6GAL1(1), STT3B(10) 36507006 299 162 280 88 58 33 31 80 95 2 0.544 1.000 1.000 332 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(15), AADAC(6), ABAT(4), ACADS(6), ACAT1(9), ACAT2(6), ACSM1(8), AKR1B10(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH5A1(6), ALDH7A1(2), ALDH9A1(7), BDH1(8), BDH2(4), DDHD1(17), ECHS1(3), EHHADH(5), GAD1(11), GAD2(17), HADH(3), HADHA(7), HMGCS1(2), HMGCS2(6), HSD17B4(11), HSD3B7(9), ILVBL(9), L2HGDH(5), OXCT1(10), OXCT2(7), PDHA1(1), PDHA2(16), PDHB(4), PLA1A(4), PPME1(2), PRDX6(5), RDH11(1), RDH12(3), RDH13(8) 34935927 312 162 291 97 81 48 30 72 81 0 0.201 1.000 1.000 333 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(3), ARHGAP1(8), ARHGAP4(4), ARHGAP5(34), ARHGAP6(14), ARHGEF1(15), ARHGEF11(26), ARHGEF5(8), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), BAIAP2(7), CFL1(2), DIAPH1(16), GSN(15), LIMK1(7), MYL2(9), MYLK(31), OPHN1(11), PFN1(1), PIP5K1A(4), PIP5K1B(2), PPP1R12B(17), ROCK1(22), SRC(5), TLN1(35), VCL(19) 39159206 328 162 313 91 98 45 42 63 74 6 0.0595 1.000 1.000 334 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(9), AASDH(15), AASDHPPT(1), AASS(13), ACAT1(9), ACAT2(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), ATP6V0C(2), BBOX1(6), DLST(6), DOT1L(23), ECHS1(3), EHHADH(5), EHMT1(24), EHMT2(23), GCDH(8), HADHA(7), PLOD1(12), PLOD2(18), PLOD3(21), SDS(5), SHMT1(4), SHMT2(13), TMLHE(6) 31776433 324 160 294 87 78 46 40 66 93 1 0.0306 1.000 1.000 335 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(36), ACACB(49), ACADM(7), ACAT1(9), ACAT2(6), ACSS1(18), ACSS2(20), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH6A1(8), ALDH7A1(2), ALDH9A1(7), ECHS1(3), EHHADH(5), HADHA(7), HIBCH(6), LDHA(7), LDHAL6A(4), LDHAL6B(7), LDHB(5), LDHC(1), MCEE(6), MLYCD(8), MUT(10), PCCA(15), PCCB(6), SUCLA2(3), SUCLG1(4), SUCLG2(9) 34102097 331 158 305 71 77 56 34 77 86 1 0.00127 1.000 1.000 336 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(13), CDC7(8), CDK2(5), CDT1(6), DIAPH2(18), GMNN(2), MCM10(15), MCM2(15), MCM3(8), MCM4(17), MCM5(11), MCM6(13), MCM7(8), NACA(26), PCNA(2), POLA2(6), POLD1(18), POLD2(8), POLD3(7), POLE(42), POLE2(6), PRIM1(6), RFC1(19), RFC2(3), RFC3(7), RFC4(2), RFC5(3), RPA1(6), RPA2(4), RPA3(1), RPA4(9), RPS27A(4), UBA52(2), UBB(2), UBC(9) 43588202 331 157 320 83 92 39 36 78 86 0 0.0378 1.000 1.000 337 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(7), AKR1D1(4), ARSD(6), ARSE(6), CARM1(10), CYP11B1(19), CYP11B2(12), CYP19A1(13), HEMK1(2), HSD11B1(5), HSD11B2(5), HSD17B1(5), HSD17B12(4), HSD17B2(3), HSD17B3(2), HSD17B7(5), HSD3B1(6), HSD3B2(5), LCMT1(2), LCMT2(11), METTL2B(1), METTL6(5), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), SULT2B1(2), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7), WBSCR22(5) 43003668 321 157 307 106 63 57 42 80 78 1 0.426 1.000 1.000 338 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(8), ARG1(3), ARG2(4), ASL(8), ASS1(11), CKB(7), CKM(2), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(35), DAO(15), EPRS(21), GAMT(2), GATM(5), GLUD1(5), GLUD2(17), GOT1(3), GOT2(2), LAP3(5), NOS1(45), NOS3(20), OAT(6), OTC(5), P4HA1(6), P4HA2(11), P4HA3(7), PRODH(1), PYCR1(3), PYCR2(5), PYCRL(3), RARS(9), RARS2(7) 31095388 293 157 278 91 80 37 39 77 60 0 0.284 1.000 1.000 339 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(22), ANAPC10(2), ANAPC11(1), ANAPC2(9), ANAPC4(4), ANAPC5(8), ANAPC7(7), BTRC(12), CDC16(7), CDC20(10), CDC23(7), CDC26(3), CDC27(12), CUL1(28), CUL2(10), CUL3(11), FBXW11(9), FBXW7(46), FZR1(12), ITCH(7), RBX1(1), SKP2(6), SMURF1(9), SMURF2(7), TCEB1(1), UBA1(8), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2D3(3), UBE2E1(4), UBE2E2(1), UBE2E3(3), VHL(2), WWP1(19), WWP2(18) 34701828 313 156 284 59 84 42 32 62 91 2 7.88e-05 1.000 1.000 340 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(14), AKT1(7), AKT2(11), AKT3(10), DAG1(14), GNAQ(4), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(18), PIK3CB(17), PITX2(6), PLD1(26), PLD2(22), PLD3(9), VN1R1(7) 38792129 353 156 340 106 110 43 46 78 72 4 0.121 1.000 1.000 341 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(68), ASAH1(4), CAMP(3), CASP3(2), CERK(11), CREB1(4), CREB5(9), CXCL2(2), DAG1(14), EPHB2(19), FOS(2), GNAQ(4), ITPKA(2), ITPKB(20), JUN(6), MAP2K4(12), MAP2K7(38), MAPK1(4), MAPK10(7), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7) 24269595 274 156 263 71 79 29 30 49 80 7 0.0208 1.000 1.000 342 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(11), ALOX12B(16), ALOX15(12), ALOX15B(6), ALOX5(15), CBR1(1), CBR3(4), CYP2B6(9), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2E1(8), CYP2J2(5), CYP2U1(11), CYP4A11(4), CYP4A22(7), CYP4F2(17), CYP4F3(14), DHRS4(6), EPHX2(5), GGT1(9), GPX5(2), GPX7(4), LTA4H(5), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PTGDS(3), PTGES(1), PTGES2(6), PTGIS(10), PTGS1(15), PTGS2(7), TBXAS1(9) 33925494 304 155 292 79 107 32 28 83 52 2 0.00447 1.000 1.000 343 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(36), ACAT1(9), ACAT2(6), ACYP1(2), ACYP2(3), ADH5(4), AKR1B1(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), DLAT(9), DLD(14), GLO1(3), GRHPR(4), HAGH(6), HAGHL(2), LDHA(7), LDHB(5), LDHC(1), LDHD(2), MDH1(5), MDH2(2), ME1(2), ME2(10), ME3(8), PC(19), PCK1(14), PDHA1(1), PDHA2(16), PDHB(4), PKLR(12) 31702004 297 155 278 96 77 48 34 63 75 0 0.432 1.000 1.000 344 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(26), CD3E(3), CD4(11), CREBBP(59), CSK(10), GNAS(54), GNB1(2), GNGT1(4), HLA-DRA(7), HLA-DRB1(2), LCK(5), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PTPRC(30), ZAP70(16) 19792964 273 154 251 90 93 25 25 62 67 1 0.541 1.000 1.000 345 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(26), CD3E(3), CD4(11), CREBBP(59), CSK(10), GNAS(54), GNB1(2), GNGT1(4), HLA-DRA(7), HLA-DRB1(2), LCK(5), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PTPRC(30), ZAP70(16) 19792964 273 154 251 90 93 25 25 62 67 1 0.541 1.000 1.000 346 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(11), ALDOC(11), DLAT(9), DLD(14), ENO1(4), ENO2(6), ENO3(4), FBP1(4), FBP2(8), GAPDH(5), GAPDHS(5), GCK(10), GOT1(3), GOT2(2), GPI(6), HK1(18), HK2(15), HK3(13), LDHA(7), LDHAL6B(7), LDHB(5), LDHC(1), MDH1(5), MDH2(2), PC(19), PCK1(14), PDHA1(1), PDHA2(16), PDHB(4), PDHX(6), PFKL(9), PFKM(6), PFKP(23), PGAM1(1), PGAM2(5), PGK1(5), PGK2(4), PKLR(12), TNFAIP1(6), TPI1(3) 36571696 310 152 300 121 97 62 27 66 58 0 0.626 1.000 1.000 347 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(5), AGTR1(1), ATF2(4), CALM1(2), CALM2(3), CALM3(2), EGFR(24), ELK1(6), GNAQ(4), GRB2(4), HRAS(2), JUN(6), MAP2K1(9), MAP2K2(6), MAP2K4(12), MAP3K1(24), MAPK1(4), MAPK3(3), MAPK8(7), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), PAK1(7), PRKCA(9), PTK2(12), PTK2B(20), RAC1(2), RAF1(11), SHC1(7), SOS1(12), SRC(5), SYT1(8) 29127629 248 151 235 75 66 27 27 57 70 1 0.201 1.000 1.000 348 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(10), ELK1(6), FOS(2), IKBKB(12), IRAK1(9), JUN(6), LY96(5), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K1(24), MAP3K7(14), MAPK14(3), MAPK8(7), MYD88(4), NFKB1(10), NFKBIA(1), PPARA(8), RELA(7), TIRAP(1), TLR10(12), TLR2(9), TLR3(7), TLR4(33), TLR6(6), TLR7(7), TLR9(15), TOLLIP(7), TRAF6(7) 31204763 258 151 246 69 51 35 32 69 70 1 0.0457 1.000 1.000 349 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(8), ARSB(4), FUCA1(2), FUCA2(5), GALNS(4), GBA(14), GLB1(9), GNS(10), GUSB(12), HEXA(2), HEXB(3), HGSNAT(8), HPSE(11), HPSE2(13), HYAL1(7), HYAL2(10), IDS(4), IDUA(5), LCT(32), MAN2B1(23), MAN2B2(25), MAN2C1(15), MANBA(11), NAGLU(11), NEU1(4), NEU2(9), NEU3(5), NEU4(7), SPAM1(11) 29738914 284 150 279 75 79 47 42 58 58 0 0.0116 1.000 1.000 350 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(21), ADRBK2(8), ARRB2(3), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CLCA1(10), CLCA2(12), CLCA4(20), CNGA3(13), CNGA4(20), CNGB1(21), GNAL(5), GUCA1A(3), GUCA1B(3), GUCA1C(5), PDC(3), PDE1C(17), PRKACA(9), PRKACB(6), PRKACG(9), PRKG1(15), PRKG2(20), PRKX(6) 26308908 264 150 249 73 71 25 34 69 65 0 0.0793 1.000 1.000 351 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(7), BAD(4), GRB2(4), HRAS(2), IGF1R(24), IRS1(33), MAP2K1(9), MAPK1(4), MAPK3(3), PIK3CA(101), PIK3R1(17), RAF1(11), SHC1(7), SOS1(12), YWHAH(3) 16325379 241 149 174 51 50 55 49 43 42 2 0.000142 1.000 1.000 352 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(10), CALCR(6), CALCRL(11), CD97(11), CRHR1(14), CRHR2(4), ELTD1(26), EMR1(18), EMR2(12), GHRHR(6), GIPR(7), GLP1R(2), GLP2R(12), GPR64(15), LPHN1(23), LPHN2(32), LPHN3(32), SCTR(5), VIPR1(3), VIPR2(5) 23066777 254 148 244 59 57 37 27 88 45 0 0.00141 1.000 1.000 353 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(5), ALAS1(5), ALAS2(16), BLVRA(7), BLVRB(1), COX10(2), COX15(5), CP(13), CPOX(5), EARS2(4), EPRS(21), FECH(8), FTH1(5), FTMT(10), GUSB(12), HCCS(6), HMBS(4), HMOX1(8), HMOX2(1), MMAB(3), PPOX(10), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7), UROD(3), UROS(6) 36042792 272 148 262 81 54 40 36 76 66 0 0.299 1.000 1.000 354 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(10), CREBBP(59), DUSP1(3), EP300(39), IKBKB(12), IL1B(7), MAP2K3(11), MAP2K6(1), MAP3K7(14), MAPK11(2), MAPK14(3), MYD88(4), NFKB1(10), NFKBIA(1), NR3C1(10), RELA(7), TGFBR1(10), TGFBR2(32), TLR2(9), TNF(3) 25360186 247 148 233 59 51 29 35 56 76 0 0.0279 1.000 1.000 355 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACAA2(13), ACADL(8), ACADM(7), ACADS(6), ACADSB(9), ACAT1(9), ACAT2(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH6A1(8), ALDH9A1(7), AOX1(18), BCAT1(6), BCKDHA(14), BCKDHB(6), ECHS1(3), EHHADH(5), HADHA(7), HADHB(6), HIBADH(3), IVD(5), MCCC1(5), MCCC2(10), MCEE(6), MUT(10), OXCT1(10), PCCA(15), PCCB(6), SDS(5) 30982747 294 147 270 72 55 51 35 60 92 1 0.0357 1.000 1.000 356 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(8), ALDH5A1(6), CAD(31), CPS1(35), EPRS(21), GAD1(11), GAD2(17), GCLC(4), GCLM(4), GFPT1(9), GLS(13), GLS2(8), GLUD1(5), GLUL(7), GMPS(10), GOT1(3), GOT2(2), GPT(8), GPT2(4), GSS(2), NADSYN1(13), PPAT(7), QARS(10) 28590427 242 146 235 71 57 34 34 64 53 0 0.204 1.000 1.000 357 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(3), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH7A1(2), ALDH9A1(7), AMDHD1(4), AOC2(14), AOC3(18), ASPA(4), CARM1(10), CNDP1(5), DDC(14), FTCD(9), HAL(5), HARS(10), HARS2(5), HDC(13), HEMK1(2), HNMT(3), LCMT1(2), LCMT2(11), MAOA(6), MAOB(6), METTL2B(1), METTL6(5), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), PRPS1(4), PRPS2(5), UROC1(15), WBSCR22(5) 34140304 307 146 283 76 71 35 36 72 91 2 0.0447 1.000 1.000 358 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(16), CALM1(2), CALM2(3), CALM3(2), CRKL(2), GNAQ(4), GRB2(4), HRAS(2), JUN(6), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP3K1(24), MAPK1(4), MAPK14(3), MAPK3(3), MAPK8(7), PAK1(7), PLCG1(27), PRKCA(9), PTK2B(20), RAC1(2), RAF1(11), SHC1(7), SOS1(12), SRC(5), SYT1(8) 24564229 228 145 216 58 71 25 23 51 57 1 0.0267 1.000 1.000 359 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(21), BAIAP2(7), CASP1(8), CASP3(2), CASP7(5), CASP8(24), GAPDH(5), INSR(26), ITCH(7), MAGI1(30), MAGI2(36), RERE(37), WWP1(19), WWP2(18) 20431028 245 144 235 54 52 27 30 62 72 2 0.0192 1.000 1.000 360 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(4), CDC42(3), CREB1(4), DAXX(14), DDIT3(5), ELK1(6), GRB2(4), HMGN1(2), HRAS(2), HSPB1(2), HSPB2(2), MAP2K4(12), MAP2K6(1), MAP3K1(24), MAP3K5(18), MAP3K7(14), MAP3K9(7), MAPK14(3), MAPKAPK2(4), MAPKAPK5(6), MAX(4), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), MKNK1(6), MYC(6), PLA2G4A(8), RAC1(2), RIPK1(5), RPS6KA5(9), SHC1(7), STAT1(14), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TRADD(2), TRAF2(5) 31796384 266 144 255 72 66 38 32 54 73 3 0.0607 1.000 1.000 361 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(6), B4GALT5(5), C1GALT1(4), C1GALT1C1(6), GALNT1(4), GALNT10(10), GALNT11(7), GALNT12(6), GALNT13(14), GALNT14(15), GALNT2(9), GALNT3(6), GALNT4(6), GALNT5(14), GALNT6(7), GALNT7(4), GALNT8(12), GALNT9(6), GALNTL5(5), GCNT1(4), GCNT3(5), GCNT4(8), OGT(10), ST3GAL1(7), ST3GAL2(11), ST6GALNAC1(7), WBSCR17(37) 27814492 235 143 227 81 75 27 26 61 45 1 0.751 1.000 1.000 362 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(6), ARSD(6), ARSE(6), ASAH1(4), B4GALT6(9), CERK(11), DEGS1(2), DEGS2(3), ENPP7(5), GAL3ST1(14), GALC(5), GBA(14), GLA(3), GLB1(9), LCT(32), NEU1(4), NEU2(9), NEU3(5), NEU4(7), PPAP2A(5), PPAP2B(5), PPAP2C(6), SGMS1(5), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(8), SMPD2(3), SMPD3(11), SMPD4(13), SPHK1(10), SPHK2(11), SPTLC1(6), SPTLC2(8), UGCG(4), UGT8(7) 30746838 265 142 257 94 81 36 35 56 57 0 0.449 1.000 1.000 363 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(4), BCR(18), BLNK(8), ELK1(6), FOS(2), GRB2(4), HRAS(2), JUN(6), LYN(9), MAP2K1(9), MAP3K1(24), MAPK1(4), MAPK3(3), MAPK8IP3(16), PAPPA(35), RAC1(2), RPS6KA1(10), RPS6KA3(6), SHC1(7), SOS1(12), SYK(11), VAV1(21), VAV2(14), VAV3(16) 27692989 249 142 238 84 68 33 29 63 56 0 0.379 1.000 1.000 364 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), DAG1(14), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), NFAT5(17), PDE6A(11), PDE6B(15), PDE6C(8), PDE6D(1), PDE6G(1), PDE6H(3), SLC6A13(13), TF(19) 30796430 278 142 270 101 92 35 36 64 48 3 0.405 1.000 1.000 365 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(3), CALM3(2), CHUK(10), EGR2(9), EGR3(9), GNAQ(4), MAP3K1(24), MYC(6), NFATC1(20), NFATC2(32), NFKB1(10), NFKBIA(1), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RELA(7), SYT1(8), VIP(9), VIPR2(5) 23855646 263 142 246 76 84 35 20 52 72 0 0.0818 1.000 1.000 366 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ACADL(8), ACADM(7), ACADSB(9), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), AOC2(14), AOC3(18), CNDP1(5), DPYD(25), DPYS(12), ECHS1(3), EHHADH(5), GAD1(11), GAD2(17), HADHA(7), MLYCD(8), SDS(5), SMS(6), UPB1(6) 24939311 255 141 238 58 58 33 30 63 71 0 0.00433 1.000 1.000 367 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(8), ACTN2(34), BCAR1(16), CSK(10), CTNNA1(24), CTNNA2(32), CTNNB1(36), PTK2(12), PXN(9), SRC(5), VCL(19) 16621017 205 141 189 60 68 18 24 55 37 3 0.141 1.000 1.000 368 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(8), POLA2(6), POLB(8), POLD1(18), POLD2(8), POLD3(7), POLE(42), POLE2(6), POLE3(4), POLE4(1), POLG(10), POLG2(5), POLH(9), POLI(4), POLK(10), POLL(4), POLM(14), POLQ(46), PRIM1(6), PRIM2(10), REV1(13), REV3L(61), RFC5(3) 35097861 303 141 293 91 67 49 33 63 87 4 0.563 1.000 1.000 369 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(14), CFL1(2), GNAQ(4), GNAS(54), GNB1(2), GNGT1(4), HRAS(2), LIMK1(7), MAP2K1(9), MAPK1(4), MAPK3(3), MYL2(9), NOX1(8), PIK3C2G(18), PLCB1(24), PPP1R12B(17), PRKCA(9), PTK2(12), RAF1(11), ROCK2(20) 21804196 234 140 218 41 80 28 21 54 51 0 0.000262 1.000 1.000 370 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(11), AZIN1(4), BTG1(1), CBX3(5), CLDN5(4), CLOCK(8), CRY1(4), CRY2(9), DAZAP2(7), DNAJA1(13), EIF4G2(1), ETV6(9), G0S2(3), GFRA1(13), GSTM3(3), GSTP1(2), HERPUD1(3), HSPA8(5), IDI1(3), KLF9(3), MYF6(5), NCKAP1(17), NCOA4(9), NR1D2(11), PER1(11), PER2(20), PPP1R3C(4), PPP2CB(4), PSMA4(4), PURA(3), SF3A3(3), SUMO3(8), TOB1(3), TUBB3(12), UCP3(6), UGP2(9), VAPA(4), ZFR(18) 31466894 262 140 252 82 63 30 33 57 78 1 0.582 1.000 1.000 371 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), AOC2(14), AOC3(18), DDC(14), EPX(18), ESCO1(13), ESCO2(11), GOT1(3), GOT2(2), HPD(4), LPO(14), MAOA(6), MAOB(6), MIF(2), MPO(12), NAT6(4), PNPLA3(4), PRDX6(5), SH3GLB1(5), TAT(7), TPO(35) 29319735 236 140 219 53 61 21 17 62 73 2 0.0499 1.000 1.000 372 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(17), ATP4B(5), ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B1(25), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), ATP7A(16), ATP7B(19), COX10(2), COX4I1(4), COX5A(1), COX5B(1), COX6B1(2), COX6C(1), COX7A1(2), COX7B(3), COX7C(1), COX8A(1), NDUFA1(2), NDUFA10(4), NDUFA4(1), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(8), NDUFS2(8), NDUFV1(6), NDUFV2(2), PPA2(4), SDHA(15), SDHB(4), SHMT1(4), UQCRB(2), UQCRC1(3), UQCRFS1(4) 32871689 287 140 269 81 79 40 40 57 69 2 0.0798 1.000 1.000 373 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), FPGT(12), FUK(12), GMDS(2), GMPPA(8), GMPPB(6), HK1(18), HK2(15), HK3(13), HSD3B7(9), KHK(2), LHPP(4), MPI(3), MTMR1(8), MTMR2(10), MTMR6(14), PFKFB1(8), PFKFB2(6), PFKFB3(10), PFKFB4(6), PFKL(9), PFKM(6), PFKP(23), PGM2(1), PHPT1(2), PMM1(4), PMM2(3), RDH11(1), RDH12(3), RDH13(8), SORD(3), TPI1(3), TSTA3(11) 32223833 290 139 282 95 95 48 32 52 63 0 0.110 1.000 1.000 374 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(6), B4GALT1(6), B4GALT2(9), FBP2(8), GAA(11), GALE(2), GALK1(4), GALK2(3), GALT(3), GANAB(21), GCK(10), GLA(3), GLB1(9), HK1(18), HK2(15), HK3(13), LALBA(1), LCT(32), MGAM(28), PFKM(6), PFKP(23), PGM1(4), PGM3(13) 28031353 248 138 230 93 81 33 23 61 50 0 0.757 1.000 1.000 375 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(5), CAPN1(8), CAPN2(11), CAPNS1(6), CAPNS2(3), CXCR3(3), EGF(15), EGFR(24), HRAS(2), ITGA1(10), ITGB1(12), MAPK1(4), MAPK3(3), MYL2(9), MYLK(31), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PTK2(12), PXN(9), TLN1(35) 28243838 246 138 236 91 82 39 23 51 50 1 0.499 1.000 1.000 376 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(6), AKR1B10(6), B4GALT1(6), B4GALT2(9), G6PC2(1), GAA(11), GALE(2), GALK1(4), GALK2(3), GALT(3), GANC(10), GCK(10), GLA(3), GLB1(9), HK1(18), HK2(15), HK3(13), HSD3B7(9), LALBA(1), LCT(32), MGAM(28), PFKL(9), PFKM(6), PFKP(23), PGM1(4), PGM3(13), RDH11(1), RDH12(3), RDH13(8), UGP2(9) 33295060 275 136 261 108 96 37 28 60 54 0 0.849 1.000 1.000 377 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(5), DLG4(8), EPHB2(19), F2(15), F2RL1(2), F2RL2(5), F2RL3(6), JUN(6), MAP2K5(3), MAPK1(4), MAPK7(9), MAPK8(7), MYEF2(10), PLD1(26), PLD2(22), PLD3(9), PTK2(12), RAF1(11), RASAL1(11), SRC(5), TEC(5), VAV1(21) 23632299 221 136 216 57 65 28 23 50 55 0 0.0493 1.000 1.000 378 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(11), BCL2(4), BID(3), BIRC2(8), BIRC3(12), CASP10(8), CASP3(2), CASP6(2), CASP7(5), CASP8(24), CASP9(4), CFLAR(3), CHUK(10), DFFA(5), DFFB(5), FADD(4), GAS2(4), LMNA(13), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), SPTAN1(30), TNFRSF10A(3), TNFRSF10B(3), TNFRSF25(9), TNFSF10(10), TNFSF12(2), TRADD(2), TRAF2(5) 28780195 214 135 204 58 48 33 18 56 58 1 0.247 1.000 1.000 379 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(9), ACP2(6), ACP5(4), ACPP(8), ACPT(6), ALPI(7), ALPL(10), ALPP(16), ALPPL2(6), CYP19A1(13), CYP1A1(10), CYP1A2(6), CYP2A13(15), CYP2A6(8), CYP2A7(9), CYP2B6(9), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2D6(15), CYP2E1(8), CYP2F1(13), CYP2J2(5), CYP3A4(3), CYP3A5(3), CYP3A7(5), CYP4B1(12), CYP51A1(13), PON1(4) 25398139 246 134 235 78 88 27 22 56 53 0 0.173 1.000 1.000 380 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(26), EXT2(8), EXTL1(8), EXTL2(2), EXTL3(15), GLCE(9), HS2ST1(4), HS3ST1(10), HS3ST2(12), HS3ST3A1(5), HS3ST3B1(5), HS3ST5(10), HS6ST1(9), HS6ST2(11), HS6ST3(9), NDST1(18), NDST2(18), NDST3(23), NDST4(23) 17839649 225 134 213 76 68 34 27 66 29 1 0.437 1.000 1.000 381 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(28), CALM1(2), CALM2(3), CALM3(2), CAPN2(11), CAPNS1(6), CAPNS2(3), EP300(39), HDAC1(10), HDAC2(6), MEF2D(11), NFATC1(20), NFATC2(32), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKCA(9), SYT1(8) 20858772 221 132 208 55 70 26 22 49 54 0 0.00534 1.000 1.000 382 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(36), ACADL(8), ACADM(7), ACADSB(9), ACAT1(9), ACAT2(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH6A1(8), ALDH9A1(7), ECHS1(3), EHHADH(5), HADHA(7), LDHA(7), LDHB(5), LDHC(1), MCEE(6), MLYCD(8), MUT(10), PCCA(15), PCCB(6), SDS(5), SUCLA2(3), SUCLG1(4), SUCLG2(9) 28474853 266 132 243 61 60 43 32 57 74 0 0.0223 1.000 1.000 383 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(9), GTF2A1(3), GTF2B(3), GTF2E1(7), GTF2F1(11), HDAC3(10), NCOA1(27), NCOA2(33), NCOA3(18), NCOR2(52), POLR2A(27), RARA(4), RXRA(13), TBP(8) 21527996 225 132 222 82 63 41 25 50 43 3 0.590 1.000 1.000 384 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(5), ACTN1(8), ACTN2(34), CAPN1(8), CAPNS1(6), CAPNS2(3), ITGA1(10), ITGB1(12), ITGB3(8), PTK2(12), PXN(9), RAC1(2), SPTAN1(30), SRC(5), TLN1(35) 24615049 187 132 179 70 79 21 13 47 27 0 0.623 1.000 1.000 385 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(4), BRAF(22), CREB1(4), CREB5(9), DUSP4(3), DUSP6(5), DUSP9(10), EEF2K(15), EIF4E(2), GRB2(4), MAP2K1(9), MAP2K2(6), MAP3K8(2), MAPK1(4), MAPK3(3), MKNK1(6), MKNK2(10), MOS(11), NFKB1(10), RAP1A(4), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), SHC1(7), SOS1(12), SOS2(19), TRAF3(8) 25452530 218 131 202 81 59 32 14 57 56 0 0.847 1.000 1.000 386 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ACADM(7), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), AOC2(14), AOC3(18), CNDP1(5), DPYD(25), DPYS(12), ECHS1(3), EHHADH(5), GAD1(11), GAD2(17), HADHA(7), HIBCH(6), MLYCD(8), SMS(6), SRM(4), UPB1(6) 23163802 226 130 209 49 52 28 26 56 64 0 0.00353 1.000 1.000 387 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(5), ADCY1(26), CAP1(2), CCNB1(4), CDC25C(11), GNAI1(4), GNAS(54), GNB1(2), GNGT1(4), HRAS(2), MAPK1(4), MAPK3(3), MYT1(26), PIN1(2), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RPS6KA1(10), SRC(5) 17707353 208 130 194 72 77 26 13 48 42 2 0.542 1.000 1.000 388 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(20), DYRK1B(19), GLI2(23), GLI3(69), GSK3B(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), SHH(6), SMO(19), SUFU(8) 14244054 217 130 207 79 70 29 18 51 47 2 0.362 1.000 1.000 389 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(7), CDC42(3), CREB1(4), CREB5(9), DUSP1(3), DUSP10(11), EEF2K(15), EIF4E(2), ELK1(6), HSPB1(2), IL1R1(5), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K10(17), MAP3K4(32), MAP3K5(18), MAP3K7(14), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPKAPK2(4), MAPKAPK5(6), MKNK1(6), MKNK2(10), MYEF2(10), NFKB1(10), NR2C2(10), SRF(5), TRAF6(7) 28881519 254 130 243 70 60 49 29 55 60 1 0.0243 1.000 1.000 390 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(6), AGMAT(5), ALDH18A1(12), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), AMD1(8), AOC2(14), AOC3(18), ARG1(3), ARG2(4), ASL(8), ASS1(11), CPS1(35), GATM(5), MAOA(6), MAOB(6), NAGS(2), ODC1(4), OTC(5), SAT1(3), SMS(6), SRM(4) 25312769 233 129 219 46 55 25 30 59 64 0 0.00200 1.000 1.000 391 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), AOC2(14), AOC3(18), DDC(14), EPX(18), GOT1(3), GOT2(2), HPD(4), LPO(14), MAOA(6), MAOB(6), MPO(12), PRDX1(3), PRDX2(3), PRDX6(5), TAT(7), TPO(35) 18976283 203 129 187 52 55 20 17 55 54 2 0.0962 1.000 1.000 392 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(3), CALM3(2), DLG4(8), GRIN1(11), GRIN2A(23), GRIN2B(31), GRIN2C(13), GRIN2D(12), NOS1(45), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), SYT1(8) 21939046 242 128 231 86 77 34 25 53 53 0 0.362 1.000 1.000 393 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(15), ABAT(4), ACADS(6), ACAT1(9), ACAT2(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH5A1(6), ALDH9A1(7), ECHS1(3), EHHADH(5), GAD1(11), GAD2(17), HADHA(7), L2HGDH(5), OXCT1(10), PDHA1(1), PDHA2(16), PDHB(4), SDHB(4), SDS(5) 22138651 219 126 203 68 51 31 21 54 62 0 0.303 1.000 1.000 394 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(26), GNAS(54), GNB1(2), GNGT1(4), PPP2CA(5), PRKAA1(9), PRKAA2(11), PRKAB1(13), PRKAB2(6), PRKACB(6), PRKACG(9), PRKAG1(6), PRKAG2(8), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12) 13235468 188 125 174 48 68 20 14 36 48 2 0.155 1.000 1.000 395 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(13), ACO1(9), ACO2(12), CLYBL(4), CS(1), DLD(14), DLST(6), FH(4), IDH1(5), IDH2(8), IDH3A(3), IDH3B(3), IDH3G(7), MDH1(5), MDH2(2), OGDH(13), OGDHL(25), PC(19), PCK1(14), PCK2(12), SDHA(15), SDHB(4), SDHC(2), SDHD(3), SUCLA2(3), SUCLG1(4), SUCLG2(9) 25715662 219 125 209 58 67 35 24 39 54 0 0.0319 1.000 1.000 396 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(12), CS(1), DLAT(9), DLD(14), DLST(6), FH(4), IDH2(8), IDH3A(3), IDH3B(3), IDH3G(7), MDH1(5), MDH2(2), OGDH(13), PC(19), PDHA1(1), PDHA2(16), PDHB(4), PDHX(6), PDK1(3), PDK2(2), PDK3(8), PDK4(6), PDP2(5), SDHA(15), SDHB(4), SDHC(2), SDHD(3), SUCLA2(3), SUCLG1(4), SUCLG2(9) 24468445 197 125 187 62 49 33 24 40 51 0 0.365 1.000 1.000 397 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(6), ANXA2(4), ANXA3(1), ANXA4(8), ANXA5(7), ANXA6(4), CYP11A1(8), EDN1(4), EDNRA(5), EDNRB(36), HPGD(3), HSD11B1(5), HSD11B2(5), PLA2G4A(8), PRL(3), PTGDR(8), PTGDS(3), PTGER2(8), PTGER4(15), PTGFR(6), PTGIR(2), PTGIS(10), PTGS1(15), PTGS2(7), S100A6(1), SCGB1A1(3), TBXAS1(9) 17727559 194 125 182 59 46 15 27 59 46 1 0.422 1.000 1.000 398 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAA2(13), ACAD8(6), ACAD9(9), ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), AKR1B10(6), AKR1C4(7), AKR1D1(4), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), BAAT(6), CEL(20), CYP27A1(8), CYP7A1(7), HADHB(6), HSD3B7(9), LIPA(3), RDH11(1), RDH12(3), RDH13(8), SLC27A5(6), SOAT1(12), SOAT2(4), SRD5A1(2) 27335024 249 124 231 73 56 37 43 52 61 0 0.163 1.000 1.000 399 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(43), C5(15), C6(19), C7(11), ICAM1(5), IL1A(2), IL6(1), ITGA4(21), ITGAL(28), ITGB1(12), ITGB2(12), SELP(14), SELPLG(10), TNF(3), VCAM1(13) 21350161 209 124 198 61 54 27 22 62 44 0 0.0709 1.000 1.000 400 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(11), EGF(15), EGFR(24), GRB2(4), HRAS(2), MAP2K1(9), MAPK1(4), MAPK3(3), PTPRB(28), RAF1(11), RASA1(28), SHC1(7), SOS1(12), SPRY1(2), SPRY3(8), SPRY4(8), SRC(5) 21531432 181 123 173 55 43 29 17 53 38 1 0.378 1.000 1.000 401 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(35), COL4A2(24), COL4A3(19), COL4A4(25), COL4A5(26), COL4A6(15), P4HB(5), SLC23A1(8), SLC23A2(14), SLC2A1(9), SLC2A3(11) 21774056 191 123 185 66 51 33 21 47 37 2 0.228 1.000 1.000 402 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(14), AGT(5), AGTR1(1), AGTR2(6), CMA1(3), COL4A1(35), COL4A2(24), COL4A3(19), COL4A4(25), COL4A5(26), COL4A6(15), REN(9) 21858405 182 122 179 59 42 36 18 47 37 2 0.256 1.000 1.000 403 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(10), CARS(11), DARS(2), EPRS(21), FARS2(9), GARS(6), HARS(10), IARS(15), KARS(9), LARS(13), LARS2(12), MARS(10), MARS2(6), NARS(5), QARS(10), RARS(9), SARS(11), TARS(17), WARS(5), WARS2(14), YARS(9) 27469235 214 122 207 56 55 26 33 57 43 0 0.0932 1.000 1.000 404 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(10), IFNA1(1), IFNB1(4), IKBKB(12), IL1A(2), IL1B(7), IL1R1(5), IL1RAP(8), IL1RN(2), IL6(1), IRAK1(9), IRAK2(11), IRAK3(10), JUN(6), MAP2K3(11), MAP2K6(1), MAP3K1(24), MAP3K7(14), MAPK14(3), MAPK8(7), MYD88(4), NFKB1(10), NFKBIA(1), RELA(7), TGFB1(3), TGFB2(10), TGFB3(11), TNF(3), TOLLIP(7), TRAF6(7) 25597541 211 122 200 60 45 31 20 48 66 1 0.229 1.000 1.000 405 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(3), ERCC3(9), GTF2A2(1), GTF2B(3), GTF2E1(7), GTF2E2(4), GTF2F2(3), GTF2H1(6), GTF2H4(9), ILK(11), MNAT1(4), POLR1A(23), POLR1B(11), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLR3B(16), POLR3D(7), POLR3E(6), POLR3H(2), POLR3K(2), TAF13(1), TAF5(4), TAF6(15), TAF7(8), TBP(8) 30042255 222 122 217 81 62 23 32 44 61 0 0.809 1.000 1.000 406 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AGPAT6(7), AGPS(10), CHPT1(4), ENPP2(11), ENPP6(10), PAFAH1B1(16), PAFAH1B2(1), PAFAH1B3(3), PAFAH2(5), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLD1(26), PLD2(22), PPAP2A(5), PPAP2B(5), PPAP2C(6) 20105123 208 121 192 48 53 27 35 53 40 0 0.0103 1.000 1.000 407 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(34), ARHGEF1(15), GNA12(2), GNA13(10), GNAQ(4), GNB1(2), GNGT1(4), MYL2(9), MYLK(31), PLCB1(24), PPP1R12B(17), PRKCA(9), ROCK1(22) 17867773 183 121 174 45 43 23 26 42 43 6 0.0747 1.000 1.000 408 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(6), CSNK1D(5), DRD1(7), DRD2(14), GRM1(52), PLCB1(24), PPP1CA(3), PPP1R1B(3), PPP2CA(5), PPP3CA(14), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12) 13681358 180 120 172 50 50 28 19 43 40 0 0.0626 1.000 1.000 409 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(5), CHIA(7), CHIT1(5), CMAS(7), CTBS(4), CYB5R1(4), CYB5R3(4), GFPT1(9), GFPT2(9), GNE(12), GNPDA1(4), GNPDA2(7), GNPNAT1(6), HEXA(2), HEXB(3), HK1(18), HK2(15), HK3(13), LHPP(4), MTMR1(8), MTMR2(10), MTMR6(14), NAGK(2), NANS(9), NPL(5), PGM3(13), PHPT1(2), RENBP(5), UAP1(6) 24748721 212 120 203 58 53 36 26 53 44 0 0.0356 1.000 1.000 410 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(13), CCNB1(4), CCND1(3), CCND2(2), CCND3(1), CCNE1(7), CCNH(3), CDC25A(8), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN1B(1), CDKN2A(36), CDKN2B(1), CDKN2C(2), CDKN2D(5), E2F1(6), RB1(22), RBL1(14), TFDP1(6) 13847898 154 119 146 41 24 28 17 33 51 1 0.129 1.000 1.000 411 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(10), FADD(4), IKBKB(12), IL1A(2), IL1R1(5), IRAK1(9), MAP3K1(24), MAP3K7(14), MYD88(4), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), TLR4(33), TNF(3), TNFAIP3(16), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF6(7) 20818050 178 119 167 44 38 21 19 53 47 0 0.0862 1.000 1.000 412 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(18), CHAT(14), COMT(5), DBH(8), DDC(14), GAD1(11), GAD2(17), HDC(13), MAOA(6), PAH(10), PNMT(11), SLC18A3(17), TH(10), TPH1(6) 12429423 162 118 156 60 56 19 12 38 36 1 0.491 1.000 1.000 413 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(10), ABAT(4), ADSL(8), ADSS(6), AGXT(5), AGXT2(13), ASL(8), ASNS(10), ASPA(4), CAD(31), CRAT(14), DARS(2), DDO(7), GAD1(11), GAD2(17), GOT1(3), GOT2(2), GPT(8), GPT2(4), NARS(5), PC(19) 22500131 191 117 181 63 65 24 23 40 39 0 0.313 1.000 1.000 414 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CALM2(3), CALM3(2), CDKN1A(7), GNAQ(4), MARCKS(2), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKCA(9), SP1(6), SP3(7), SYT1(8) 17829857 187 116 178 43 67 33 15 33 39 0 0.000831 1.000 1.000 415 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(5), BIRC2(8), BIRC3(12), CASP3(2), CASP8(24), CFLAR(3), FADD(4), JUN(6), MAP2K4(12), MAP3K3(10), MAP3K7(14), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR2C2(10), RALBP1(12), RIPK1(5), TNF(3), TNFAIP3(16), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF2(5) 23586080 199 116 192 41 45 25 21 46 59 3 0.0133 1.000 1.000 416 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(55), MAP2(51), PPP1CA(3), PPP2CA(5), PRKACB(6), PRKACG(9), PRKAG1(6), PRKAR2A(3), PRKAR2B(12), PRKCE(16) 15448690 166 115 159 49 26 19 25 58 36 2 0.549 1.000 1.000 417 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(15), F2R(10), F2RL3(6), GNAI1(4), GNB1(2), GNGT1(4), HRAS(2), ITGA1(10), ITGB1(12), MAP2K1(9), MAPK1(4), MAPK3(3), PLA2G4A(8), PLCB1(24), PRKCA(9), PTGS1(15), PTK2(12), RAF1(11), SRC(5), SYK(11), TBXAS1(9) 20968990 185 115 177 49 60 19 20 51 34 1 0.0490 1.000 1.000 418 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(6), ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), FPGT(12), GCK(10), GMDS(2), GMPPA(8), GMPPB(6), HK1(18), HK2(15), HK3(13), KHK(2), MPI(3), PFKFB1(8), PFKFB3(10), PFKFB4(6), PFKM(6), PFKP(23), PMM1(4), PMM2(3), SORD(3), TPI1(3) 20635905 196 114 191 60 73 30 19 35 39 0 0.0661 1.000 1.000 419 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(15), AGT(5), AGTR2(6), EDN1(4), EDNRA(5), EDNRB(36), EGF(15), EGFR(24), FOS(2), HRAS(2), JUN(6), MYC(6), NFKB1(10), PLCG1(27), PRKCA(9), RELA(7) 17647573 179 113 166 47 46 27 17 47 42 0 0.0528 1.000 1.000 420 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(26), ADRB2(9), GNAS(54), PLCE1(27), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RAP2B(1) 12733333 161 112 151 55 61 21 13 34 31 1 0.550 1.000 1.000 421 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(18), BST1(4), CD38(7), ENPP1(12), ENPP3(16), NADK(13), NADSYN1(13), NMNAT1(6), NMNAT2(3), NMNAT3(3), NNMT(5), NNT(12), NT5C1A(9), NT5C1B(14), NT5C2(9), NT5E(5), NT5M(7), NUDT12(7) 18537128 163 111 153 53 34 25 20 35 48 1 0.461 1.000 1.000 422 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(5), ASNS(10), ASRGL1(6), CA1(4), CA12(1), CA13(4), CA14(7), CA2(7), CA3(5), CA4(8), CA5A(4), CA5B(1), CA6(4), CA7(4), CA8(4), CA9(7), CPS1(35), CTH(3), GLS(13), GLS2(8), GLUD1(5), GLUD2(17), GLUL(7), HAL(5) 18255218 174 111 167 52 33 25 30 48 38 0 0.306 1.000 1.000 423 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(22), AP2A1(15), AP2M1(8), BIN1(8), CALM1(2), CALM2(3), CALM3(2), DNM1(10), EPN1(12), EPS15(5), NME2(3), PICALM(6), PPP3CA(14), PPP3CB(8), PPP3CC(9), SYNJ1(18), SYNJ2(24), SYT1(8) 19000706 177 111 165 31 46 23 16 39 52 1 0.000154 1.000 1.000 424 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(3), CALM3(2), CAMK1(4), CAMK1G(10), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), ESRRA(4), HDAC5(15), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), PPARA(8), PPP3CA(14), PPP3CB(8), PPP3CC(9), SLC2A4(5), SYT1(8), YWHAH(3) 17568698 159 111 153 37 41 18 17 40 43 0 0.0125 1.000 1.000 425 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(11), CSF1R(26), EGF(15), EGFR(24), GRB2(4), MET(14), PDGFRA(17), PRKCA(9), SH3GLB1(5), SH3GLB2(10), SH3KBP1(22), SRC(5) 16718842 162 110 152 62 36 27 11 45 43 0 0.840 1.000 1.000 426 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(26), ADRB2(9), CFTR(23), GNAS(54), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), SLC9A3R1(4) 11269526 160 110 150 42 56 15 11 39 38 1 0.238 1.000 1.000 427 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(6), CSF1R(26), DDX20(4), E2F1(6), E2F4(2), ETS1(9), ETS2(4), ETV3(4), FOS(2), HDAC2(6), HDAC5(15), HRAS(2), JUN(6), NCOR2(52), RBL1(14), RBL2(11), SIN3A(20), SIN3B(18) 22638857 207 110 204 50 55 21 25 51 52 3 0.0649 1.000 1.000 428 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH9A1(7), AOC2(14), AOC3(18), ASPA(4), CNDP1(5), DDC(14), HAL(5), HARS(10), HDC(13), HNMT(3), MAOA(6), MAOB(6), PRPS1(4), PRPS2(5) 20995725 205 110 187 51 52 17 21 49 65 1 0.158 1.000 1.000 429 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(17), ABCC2(23), ABCG2(11), BCHE(28), CES1(21), CES2(10), CYP3A4(3), CYP3A5(3), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5) 19674377 167 110 159 36 33 25 18 41 50 0 0.0200 1.000 1.000 430 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(10), CREBBP(59), EP300(39), FADD(4), HDAC3(10), IKBKB(12), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF6(7) 19097195 179 110 172 47 46 25 19 38 51 0 0.0787 1.000 1.000 431 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(7), BLVRB(1), CP(13), CPOX(5), EPRS(21), FECH(8), GUSB(12), HCCS(6), HMBS(4), HMOX1(8), HMOX2(1), PPOX(10), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2B15(6), UGT2B4(6), UROD(3), UROS(6) 23481006 173 109 168 50 37 25 20 47 44 0 0.247 1.000 1.000 432 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(7), AP2A1(15), AP2M1(8), ARF1(6), BAD(4), BTK(5), EEA1(17), GRASP(3), GSK3A(6), GSK3B(9), LYN(9), PDPK1(1), PFKL(9), PFKM(6), PFKP(23), PLCG1(27), PRKCE(16), PRKCZ(4), RAB5A(4), RAC1(2), RPS6KB1(6), VAV2(14) 21686436 201 109 195 60 66 32 24 34 44 1 0.134 1.000 1.000 433 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ACAA2(13), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), AKR1C4(7), AKR1D1(4), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), BAAT(6), CEL(20), CYP27A1(8), CYP7A1(7), HADHB(6), SOAT2(4), SRD5A1(2) 19967849 199 108 184 57 43 24 31 44 57 0 0.206 1.000 1.000 434 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(4), BAX(3), BCL2(4), CASP8(24), FADD(4), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK1(4), MAPK3(3), MAPK8(7), NFKB1(10), NSMAF(14), RAF1(11), RELA(7), RIPK1(5), SMPD1(8), TNFRSF1A(6), TRADD(2), TRAF2(5) 17555493 166 108 154 42 45 24 15 28 51 3 0.0582 1.000 1.000 435 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), IL6(1), IL6R(4), IL6ST(11), JAK1(22), JAK2(14), JAK3(18), JUN(6), MAP2K1(9), MAPK3(3), PTPN11(10), RAF1(11), SHC1(7), SOS1(12), SRF(5), STAT3(9) 20643189 162 108 153 48 33 24 18 52 32 3 0.328 1.000 1.000 436 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(6), ARSB(4), ARSD(6), ARSE(6), ASAH1(4), GAL3ST1(14), GALC(5), GBA(14), GLA(3), GLB1(9), LCT(32), NEU1(4), NEU2(9), NEU3(5), NEU4(7), PPAP2A(5), PPAP2B(5), PPAP2C(6), SMPD1(8), SMPD2(3), SPTLC1(6), SPTLC2(8), UGCG(4) 20752315 173 107 169 67 52 23 29 33 36 0 0.734 1.000 1.000 437 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(8), GPLD1(15), PGAP1(12), PIGA(3), PIGB(11), PIGC(6), PIGG(16), PIGK(5), PIGL(5), PIGM(4), PIGN(12), PIGO(13), PIGP(1), PIGQ(14), PIGS(8), PIGT(15), PIGV(7), PIGW(6), PIGX(3), PIGZ(11) 20669751 175 107 161 52 37 18 21 50 48 1 0.425 1.000 1.000 438 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(6), BCAT2(11), COASY(5), DPYD(25), DPYS(12), ENPP1(12), ENPP3(16), ILVBL(9), PANK1(14), PANK2(10), PANK3(6), PANK4(9), PPCDC(2), PPCS(2), UPB1(6), VNN1(8) 14984422 153 107 148 31 32 20 21 48 32 0 0.00330 1.000 1.000 439 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(10), CREB1(4), CREBBP(59), EP300(39), NCOA3(18), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RARA(4), RXRA(13) 17701360 191 106 182 56 51 25 23 35 57 0 0.190 1.000 1.000 440 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(11), ARHGDIB(1), BIRC2(8), BIRC3(12), CASP1(8), CASP10(8), CASP2(5), CASP3(2), CASP4(7), CASP6(2), CASP7(5), CASP8(24), CASP9(4), DFFA(5), DFFB(5), GZMB(2), LMNA(13), LMNB1(5), LMNB2(11), PRF1(17) 16579462 155 106 149 36 34 18 22 36 45 0 0.104 1.000 1.000 441 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(5), EPHA4(21), EPHB1(41), FYN(10), ITGA1(10), ITGB1(12), L1CAM(22), LYN(9), RAP1B(6), SELP(14) 13532143 150 106 144 53 51 19 17 46 16 1 0.332 1.000 1.000 442 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(6), ALOX15(12), ALOX5(15), CYP1A2(6), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2E1(8), CYP2J2(5), CYP3A4(3), CYP3A43(6), CYP3A5(3), CYP3A7(5), HSD3B7(9), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), RDH11(1), RDH12(3), RDH13(8) 20812789 169 106 160 52 55 18 25 47 23 1 0.246 1.000 1.000 443 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(3), ATG3(1), ATG5(6), ATG7(13), BECN1(9), GABARAPL1(6), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNG(3), PIK3C3(17), PIK3R4(10), PRKAA1(9), PRKAA2(11), ULK1(23), ULK2(13), ULK3(5) 18212932 163 106 154 44 28 22 23 52 37 1 0.258 1.000 1.000 444 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(32), APOA1(9), APOA4(9), APOC2(3), APOC3(3), APOE(3), CETP(7), CYP7A1(7), DGAT1(10), HMGCR(8), LCAT(5), LDLR(15), LIPC(5), LPL(11), LRP1(62), SCARB1(7), SOAT1(12) 23560633 208 106 199 63 72 23 28 41 42 2 0.150 1.000 1.000 445 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(5), CHUK(10), CRADD(7), IKBKB(12), JUN(6), LTA(4), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K1(24), MAP4K2(14), MAPK14(3), MAPK8(7), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), TANK(6), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(5) 20727757 161 106 156 47 35 20 20 32 52 2 0.288 1.000 1.000 446 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(6), CR1(35), CR2(29), FCGR2B(4), HLA-DRA(7), HLA-DRB1(2), ICAM1(5), ITGAL(28), ITGB2(12), PTPRC(30) 13106191 158 105 139 43 36 19 18 39 46 0 0.156 1.000 1.000 447 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(11), CD2(5), CD33(11), CD5(6), CD7(6), IFNA1(1), IFNB1(4), IFNG(3), IL10(4), IL12A(3), IL12B(3), IL13(4), IL3(3), IL4(4), ITGAX(15), TLR2(9), TLR4(33), TLR7(7), TLR9(15) 15845915 147 105 140 50 35 16 18 56 22 0 0.423 1.000 1.000 448 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(8), FUCA1(2), FUCA2(5), GLB1(9), HEXA(2), HEXB(3), LCT(32), MAN2B1(23), MAN2B2(25), MAN2C1(15), MANBA(11), NEU1(4), NEU2(9), NEU3(5), NEU4(7) 17466524 160 105 156 42 48 26 19 33 34 0 0.0480 1.000 1.000 449 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(13), B3GAT2(9), B3GAT3(4), B4GALT7(9), CHPF(8), CHST11(4), CHST12(7), CHST13(6), CHST14(3), CHST3(10), CHST7(8), CHSY1(12), DSE(11), UST(10), XYLT1(14), XYLT2(46) 12039935 174 105 139 59 72 14 19 24 44 1 0.700 1.000 1.000 450 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), IL2RA(3), IL2RB(3), IL2RG(12), JAK1(22), JAK3(18), JUN(6), LCK(5), MAP2K1(9), MAPK3(3), MAPK8(7), RAF1(11), SHC1(7), SOS1(12), STAT5A(13), STAT5B(15), SYK(11) 20237673 177 105 166 40 39 26 17 50 43 2 0.0319 1.000 1.000 451 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(11), BIRC2(8), BIRC3(12), CASP10(8), CASP3(2), CASP7(5), CASP8(24), CASP9(4), DFFA(5), DFFB(5), GZMB(2), PRF1(17), SCAP(18), SREBF1(18), SREBF2(17) 15597880 156 105 148 30 41 17 18 39 41 0 0.0118 1.000 1.000 452 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(7), AKR1D1(4), ARSB(4), ARSD(6), ARSE(6), CYP11B1(19), CYP11B2(12), HSD11B1(5), HSD11B2(5), HSD17B2(3), HSD17B3(2), HSD3B1(6), HSD3B2(5), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2B15(6), UGT2B4(6) 23382587 164 104 158 63 41 31 19 42 31 0 0.658 1.000 1.000 453 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(7), CARM1(10), CBS(9), CTH(3), GGT1(9), HEMK1(2), LCMT1(2), LCMT2(11), MARS(10), MARS2(6), MAT1A(8), MAT2B(5), METTL2B(1), METTL6(5), PAPSS1(6), PAPSS2(9), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), SCLY(6), SEPHS1(7), SEPHS2(5), WBSCR22(5) 21528119 173 104 165 52 41 26 26 33 46 1 0.154 1.000 1.000 454 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(14), ACE2(14), AGT(5), AGTR1(1), AGTR2(6), ANPEP(11), CMA1(3), CPA3(6), CTSA(5), CTSG(4), ENPEP(19), LNPEP(15), MAS1(4), MME(14), NLN(10), REN(9), THOP1(7) 18109382 147 103 144 55 36 19 19 38 35 0 0.764 1.000 1.000 455 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(26), CREM(6), FHL5(7), FSHB(1), FSHR(30), GNAS(54), XPO1(17) 8265301 141 102 125 33 52 19 10 43 16 1 0.127 1.000 1.000 456 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(23), POLR1B(11), POLR1C(9), POLR1D(4), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLR3A(31), POLR3B(16), POLR3G(3), POLR3H(2), POLR3K(2), ZNRD1(2) 20104287 162 102 157 46 47 18 26 36 35 0 0.152 1.000 1.000 457 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(5), C1QB(3), C1R(1), C1S(11), C2(4), C3(43), C5(15), C6(19), C7(11), C8A(13), C9(10), MASP1(7), MASP2(6), MBL2(8) 18428398 156 101 149 40 41 21 14 44 36 0 0.0899 1.000 1.000 458 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(4), GALNS(4), GLB1(9), GNS(10), GUSB(12), HEXA(2), HEXB(3), HGSNAT(8), HPSE(11), HPSE2(13), HYAL1(7), HYAL2(10), IDS(4), IDUA(5), LCT(32), NAGLU(11), SPAM1(11) 17729557 156 101 154 50 43 28 22 33 30 0 0.317 1.000 1.000 459 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(8), CCR2(6), CCR3(14), CCR4(3), CCR5(5), CCR7(5), CD28(2), CD4(11), CXCR3(3), CXCR4(1), IFNG(3), IFNGR1(11), IFNGR2(2), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL18R1(7), IL4(4), IL4R(10), TGFB1(3), TGFB2(10), TGFB3(11) 17211185 150 101 140 52 35 12 20 45 38 0 0.734 1.000 1.000 460 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(3), MRPS7(1), RPL10A(7), RPL10L(19), RPL11(3), RPL12(3), RPL13(1), RPL13A(5), RPL14(2), RPL18(1), RPL18A(2), RPL19(1), RPL22L1(1), RPL23A(3), RPL24(2), RPL26(2), RPL27(1), RPL28(2), RPL29(2), RPL3(5), RPL30(1), RPL31(3), RPL32(1), RPL34(2), RPL35(1), RPL35A(1), RPL36A(3), RPL36AL(1), RPL37(1), RPL37A(1), RPL38(2), RPL3L(4), RPL6(4), RPL8(5), RPL9(4), RPS10(2), RPS11(3), RPS13(4), RPS16(1), RPS18(1), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(2), RPS26(3), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(5), RPS6(1), RPS7(1), RPS9(3), RPSA(5) 19719644 144 100 139 49 31 19 19 41 34 0 0.890 1.000 1.000 461 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(15), EGFR(24), MAP2K1(9), MAP3K1(24), MAPK14(3), NCOR2(52), RARA(4), RXRA(13), THRA(13), THRB(5) 14919433 162 99 153 50 58 21 15 33 32 3 0.259 1.000 1.000 462 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(6), ELK1(6), EPO(3), EPOR(5), FOS(2), GRB2(4), HRAS(2), JAK2(14), JUN(6), MAP2K1(9), MAPK3(3), MAPK8(7), PLCG1(27), PTPN6(6), RAF1(11), SHC1(7), SOS1(12), STAT5A(13), STAT5B(15) 18695160 158 99 153 41 46 25 17 36 33 1 0.0553 1.000 1.000 463 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(5), C1QB(3), C1R(1), C1S(11), C2(4), C3(43), C5(15), C6(19), C7(11), C8A(13), C8B(14), C9(10), MASP1(7) 17965300 156 98 149 37 43 19 16 45 33 0 0.0503 1.000 1.000 464 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(23), IL13(4), IL4(4), JUNB(5), MAF(5), MAP2K3(11), MAPK14(3), NFATC1(20), NFATC2(32), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12) 10366845 151 98 142 49 52 22 13 21 43 0 0.140 1.000 1.000 465 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(6), DCXR(1), GUSB(12), RPE(6), UGDH(11), UGP2(9), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7), XYLB(7) 23264279 164 98 155 35 24 17 29 45 49 0 0.0422 1.000 1.000 466 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(6), BCAT2(11), IARS(15), IARS2(13), ILVBL(9), LARS(13), LARS2(12), PDHA1(1), PDHA2(16), PDHB(4), VARS(25), VARS2(16) 15945959 141 98 139 47 40 18 19 38 26 0 0.505 1.000 1.000 467 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(8), B3GNT2(6), B3GNT7(7), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT4(7), CHST1(21), CHST2(15), CHST4(7), CHST6(13), FUT8(11), ST3GAL1(7), ST3GAL2(11), ST3GAL3(3), ST3GAL4(8) 10625277 143 98 138 50 63 13 17 29 21 0 0.457 1.000 1.000 468 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(18), AMT(5), ATIC(7), FTCD(9), GART(12), MTFMT(3), MTHFD1(9), MTHFD1L(12), MTHFD2(3), MTHFR(12), MTHFS(3), MTR(26), SHMT1(4), SHMT2(13), TYMS(3) 16302903 139 98 133 39 31 19 22 33 33 1 0.0989 1.000 1.000 469 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(6), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT5(5), DDOST(1), DPAGT1(6), DPM1(2), FUT8(11), MAN1A1(6), MAN1B1(8), MGAT1(6), MGAT2(4), MGAT3(13), MGAT4A(6), MGAT4B(6), MGAT5(14), RPN1(7), RPN2(9), ST6GAL1(1) 17049742 134 98 131 46 38 17 14 35 30 0 0.523 1.000 1.000 470 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(59), EP300(39), ESR1(14), MAPK1(4), MAPK3(3), PELP1(11), SRC(5) 12564375 135 98 129 30 41 13 19 29 33 0 0.0181 1.000 1.000 471 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(11), ALDOC(11), DERA(2), FBP1(4), FBP2(8), G6PD(6), GPI(6), H6PD(8), PFKL(9), PFKM(6), PFKP(23), PGD(9), PGLS(3), PGM1(4), PGM3(13), PRPS1(4), PRPS2(5), RBKS(4), RPE(6), RPIA(3), TALDO1(6), TKT(6), TKTL1(12), TKTL2(12) 20891283 182 97 174 54 44 35 20 48 35 0 0.0724 1.000 1.000 472 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(4), CAT(6), EPX(18), LPO(14), MPO(12), MTHFR(12), PRDX6(5), SHMT1(4), SHMT2(13), TPO(35) 9966185 123 97 118 33 37 16 9 30 30 1 0.133 1.000 1.000 473 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(4), ATP6V0C(2), CAT(6), EPX(18), LPO(14), MPO(12), PRDX1(3), PRDX2(3), PRDX6(5), SHMT1(4), SHMT2(13), TPO(35) 10172507 119 97 114 34 32 16 10 32 28 1 0.196 1.000 1.000 474 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(9), ACO2(12), CS(1), DLD(14), DLST(6), FH(4), IDH1(5), IDH2(8), IDH3A(3), IDH3B(3), IDH3G(7), MDH1(5), MDH2(2), PC(19), PCK1(14), SDHA(15), SDHB(4), SUCLA2(3), SUCLG1(4), SUCLG2(9) 17756425 147 96 140 38 48 26 13 23 37 0 0.0404 1.000 1.000 475 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(5), ASNS(10), CA1(4), CA12(1), CA14(7), CA2(7), CA3(5), CA4(8), CA5A(4), CA5B(1), CA6(4), CA7(4), CA8(4), CA9(7), CPS1(35), CTH(3), GLS(13), GLS2(8), GLUD1(5), GLUL(7), HAL(5) 16350697 147 96 140 46 25 21 27 39 35 0 0.481 1.000 1.000 476 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(10), F2(15), F2R(10), F3(2), F5(26), F7(12), FGA(16), FGB(9), FGG(6), PROC(5), PROS1(16), SERPINC1(5), TFPI(7) 14126379 139 95 137 35 35 19 18 43 24 0 0.0912 1.000 1.000 477 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), CYP2C19(8), CYP2C9(5), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), ECHS1(3), EHHADH(5), ESCO1(13), ESCO2(11), HADHA(7), NAT6(4), PNPLA3(4), SH3GLB1(5), YOD1(2) 26357634 164 95 150 44 39 15 18 36 56 0 0.350 1.000 1.000 478 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(10), DUSP1(3), IKBKAP(20), IKBKB(12), LTA(4), MAP3K1(24), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), TANK(6), TNFAIP3(16), TNFRSF1B(4), TRAF1(6), TRAF2(5), TRAF3(8) 19228579 141 95 135 43 38 17 13 30 42 1 0.428 1.000 1.000 479 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(8), IL22(2), IL22RA1(4), IL22RA2(2), JAK1(22), JAK2(14), JAK3(18), SOCS3(4), STAT1(14), STAT3(9), STAT5A(13), STAT5B(15), TYK2(15) 15971100 140 94 134 44 35 17 15 32 38 3 0.561 1.000 1.000 480 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(7), AMD1(8), BHMT(8), CBS(9), CTH(3), DNMT1(21), DNMT3A(11), DNMT3B(16), MARS(10), MARS2(6), MAT1A(8), MAT2B(5), MTAP(4), MTFMT(3), MTR(26), SRM(4), TAT(7) 17870881 156 93 154 64 44 21 27 36 28 0 0.809 1.000 1.000 481 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(8), B3GNT2(6), B3GNT3(3), B3GNT4(9), B3GNT5(12), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT4(7), FUT1(6), FUT2(2), FUT3(6), FUT4(3), FUT5(4), FUT6(8), FUT7(4), FUT9(11), GCNT2(1), ST3GAL6(7), ST8SIA1(12) 13797759 128 93 121 42 36 16 15 34 27 0 0.509 1.000 1.000 482 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(10), GALNT2(9), GALNT3(6), GALNT4(6), GALNT6(7), GALNT7(4), GALNT8(12), GALNT9(6), GCNT1(4), ST3GAL1(7), ST3GAL2(11), ST3GAL4(8), WBSCR17(37) 12516894 131 93 126 48 47 9 17 37 20 1 0.843 1.000 1.000 483 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(9), B4GALNT1(7), GLB1(9), HEXA(2), HEXB(3), LCT(32), SLC33A1(7), ST3GAL1(7), ST3GAL2(11), ST3GAL5(3), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(11), ST6GALNAC6(5), ST8SIA1(12), ST8SIA5(8) 14048670 136 92 133 54 50 15 19 29 23 0 0.770 1.000 1.000 484 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), GOT1(3), GOT2(2), GPT(8), GPT2(4), MDH1(5), MDH2(2), ME1(2), ME3(8), PGK1(5), PGK2(4), PKLR(12), RPE(6), RPIA(3), TKT(6), TKTL1(12), TKTL2(12), TPI1(3) 17245746 132 92 131 66 37 27 13 31 24 0 0.963 1.000 1.000 485 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(9), ACP2(6), ACP5(4), ACP6(3), ACPP(8), ACPT(6), ENPP1(12), ENPP3(16), FLAD1(6), LHPP(4), MTMR1(8), MTMR2(10), MTMR6(14), PHPT1(2), RFK(3), TYR(18) 12977092 129 92 119 32 20 21 21 31 36 0 0.107 1.000 1.000 486 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(18), AMT(5), ATIC(7), ATP6V0C(2), GART(12), MTHFD1(9), MTHFD1L(12), MTHFD2(3), MTHFR(12), MTHFS(3), MTR(26), SHMT1(4), SHMT2(13), TYMS(3) 15409200 129 92 124 32 28 19 22 30 29 1 0.0218 1.000 1.000 487 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(8), ICAM1(5), ITGA4(21), ITGAL(28), ITGAM(13), ITGB1(12), ITGB2(12), SELE(9), SELL(7), SELP(14) 13820302 129 91 123 48 38 11 14 36 30 0 0.510 1.000 1.000 488 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), GOT1(3), GOT2(2), GPT(8), GPT2(4), MDH1(5), MDH2(2), ME1(2), ME2(10), ME3(8), PGK1(5), PKLR(12), RPE(6), RPIA(3), TKT(6), TPI1(3) 15441181 114 90 114 53 30 23 11 26 24 0 0.896 1.000 1.000 489 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(5), C1QB(3), C1R(1), C1S(11), C2(4), C3(43), C5(15), C6(19), C7(11), C8A(13), C9(10) 15129497 135 90 128 34 37 19 14 37 28 0 0.0978 1.000 1.000 490 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(6), AOC2(14), AOC3(18), CES1(21), DDHD1(17), ESCO1(13), ESCO2(11), LIPA(3), NAT6(4), PLA1A(4), PNPLA3(4), PPME1(2), PRDX6(5), SH3GLB1(5) 21663035 127 90 120 16 29 12 10 28 48 0 0.00200 1.000 1.000 491 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(18), LPO(14), MPO(12), PRDX1(3), PRDX2(3), PRDX6(5), TPO(35), TYR(18) 8317554 108 90 103 34 29 15 9 37 17 1 0.409 1.000 1.000 492 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(8), POLD1(18), POLD2(8), POLE(42), POLG(10), POLL(4), POLQ(46) 14379250 136 89 133 53 35 22 11 27 41 0 0.903 1.000 1.000 493 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), G6PD(6), GPI(6), H6PD(8), PFKM(6), PFKP(23), PGD(9), PGLS(3), PGM1(4), PGM3(13), PRPS1(4), PRPS2(5), RBKS(4), RPE(6), RPIA(3), TAL1(5), TALDO1(6), TKT(6) 17500422 152 89 145 43 36 29 16 41 30 0 0.0565 1.000 1.000 494 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(4), JAK1(22), JAK2(14), JAK3(18), PIAS1(17), PIAS3(11), PTPRU(33), REG1A(5), SOAT1(12) 11886031 136 89 120 34 35 17 12 27 42 3 0.228 1.000 1.000 495 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(4), CHUK(10), IFNG(3), IKBKB(12), IL4(4), JUN(6), MAP3K1(24), MAP3K5(18), MAP4K5(10), MAPK14(3), MAPK8(7), NFKB1(10), NFKBIA(1), RELA(7), TNFRSF9(12), TNFSF9(2), TRAF2(5) 16755679 138 88 128 31 31 15 12 31 48 1 0.118 1.000 1.000 496 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(6), ARFGAP1(5), ARFGAP3(6), ARFGEF2(37), CLTA(2), CLTB(2), COPA(21), GBF1(27), GPLD1(15), KDELR1(3), KDELR2(5), KDELR3(2) 13983485 131 88 129 36 38 20 20 31 22 0 0.0965 1.000 1.000 497 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(36), ACACB(49), FASN(34), MCAT(3), OLAH(1), OXSM(7) 13713503 130 87 125 36 37 18 17 32 25 1 0.0917 1.000 1.000 498 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(11), G6PD(6), GCLC(4), GCLM(4), GGT1(9), GPX5(2), GPX7(4), GSR(8), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(3), GSTK1(3), GSTM2(1), GSTM3(3), GSTM4(3), GSTM5(3), GSTO2(4), GSTP1(2), GSTZ1(2), IDH1(5), IDH2(8), MGST1(3), MGST2(3), MGST3(5), OPLAH(28), TXNDC12(3) 18995215 138 87 129 44 37 23 12 31 34 1 0.489 1.000 1.000 499 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(7), CYB5R3(4), GCK(10), GFPT1(9), GNE(12), GNPDA1(4), GNPDA2(7), HEXA(2), HEXB(3), HK1(18), HK2(15), HK3(13), PGM3(13), RENBP(5), UAP1(6) 14622238 128 86 124 32 43 21 17 30 17 0 0.0231 1.000 1.000 500 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(9), ACP2(6), ACP5(4), ACP6(3), ACPP(8), ACPT(6), ALPI(7), ALPL(10), ALPP(16), ALPPL2(6), CYP3A4(3), CYP3A43(6), CYP3A5(3), CYP3A7(5), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), PON1(4), PON2(5), PON3(9) 15530098 133 86 125 51 41 14 14 30 34 0 0.715 1.000 1.000 501 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(4), IL6(1), IL6R(4), JAK1(22), JAK2(14), JAK3(18), PIAS3(11), PTPRU(33), REG1A(5), SRC(5), STAT3(9) 13163867 126 86 118 35 35 17 11 26 34 3 0.244 1.000 1.000 502 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(15), EGFR(24), ERBB3(49), NRG1(24), UBE2D1(1) 8853169 113 85 102 34 35 21 14 33 10 0 0.172 1.000 1.000 503 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(5), CD3E(3), CXCR3(3), ETV5(9), IFNG(3), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL18(1), IL18R1(7), JAK2(14), JUN(6), MAP2K6(1), MAPK14(3), MAPK8(7), STAT4(14), TYK2(15) 16100621 121 85 121 38 22 17 20 32 29 1 0.428 1.000 1.000 504 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(18), CD38(7), ENPP1(12), ENPP3(16), NADSYN1(13), NMNAT1(6), NMNAT2(3), NNMT(5), NNT(12), NT5E(5), NT5M(7) 12500456 104 85 98 38 9 16 14 29 35 1 0.831 1.000 1.000 505 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(11), ALOX15(12), ALOX15B(6), ALOX5(15), ALOX5AP(3), DPEP1(4), GGT1(9), LTA4H(5), PLA2G2A(2), PLA2G6(11), PTGDS(3), PTGES(1), PTGIS(10), PTGS1(15), PTGS2(7), TBXAS1(9) 13183933 123 84 121 32 49 11 11 26 24 2 0.0294 1.000 1.000 506 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(6), ALDH18A1(12), ARG1(3), ARG2(4), ASL(8), CKB(7), CKM(2), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(35), GAMT(2), GATM(5), GLUD1(5), NAGS(2), OAT(6), ODC1(4), OTC(5), PYCR1(3), SMS(6) 15181671 127 84 126 36 33 13 18 39 24 0 0.164 1.000 1.000 507 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(5), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), NCK1(7), NCKAP1(17), NTRK1(14), PIR(3), PSMA7(4), RAC1(2), WASF1(11), WASF2(10), WASF3(23), WASL(7) 13210589 119 83 108 43 36 10 10 26 34 3 0.824 1.000 1.000 508 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(11), CYP51A1(13), DHCR24(4), DHCR7(10), EBP(2), FDFT1(5), FDPS(14), GGCX(6), GGPS1(4), HMGCR(8), HSD17B7(5), IDI1(3), IDI2(4), LSS(16), MVD(2), MVK(16), NQO1(4), NSDHL(4), PMVK(1), SQLE(10), TM7SF2(4), VKORC1(2) 16565355 148 83 132 37 34 16 14 36 48 0 0.258 1.000 1.000 509 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(11), CLOCK(8), CRY1(4), CRY2(9), CSNK1D(5), CSNK1E(10), NPAS2(18), NR1D1(11), PER1(11), PER2(20), PER3(18) 14593285 125 83 122 34 41 20 12 24 28 0 0.0741 1.000 1.000 510 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(8), FUCA1(2), FUCA2(5), GLB1(9), HEXA(2), HEXB(3), LCT(32), MAN2C1(15), MANBA(11), NEU1(4), NEU2(9), NEU3(5), NEU4(7) 14179693 112 83 111 39 29 21 12 25 25 0 0.592 1.000 1.000 511 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(18), FOS(2), GRB2(4), HRAS(2), IL3(3), IL3RA(6), JAK2(14), MAP2K1(9), MAPK3(3), PTPN6(6), RAF1(11), SHC1(7), SOS1(12), STAT5A(13), STAT5B(15) 15327294 125 81 120 43 35 19 14 32 24 1 0.511 1.000 1.000 512 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(7), GRB2(4), IL2RG(12), IL4(4), IL4R(10), IRS1(33), JAK1(22), JAK3(18), RPS6KB1(6), SHC1(7), STAT6(10) 12735176 133 81 120 30 26 15 16 24 49 3 0.312 1.000 1.000 513 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(16), CNR2(4), DNMT1(21), MTNR1A(5), MTNR1B(10), PTAFR(4), PTGDR(8), PTGER2(8), PTGER4(15), PTGFR(6), PTGIR(2), TBXA2R(11) 9535405 110 81 106 53 43 15 16 23 13 0 0.781 1.000 1.000 514 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(7), BHMT(8), CBS(9), CTH(3), DNMT1(21), DNMT3A(11), DNMT3B(16), MARS(10), MARS2(6), MAT1A(8), MAT2B(5), MTR(26) 15024210 130 80 128 55 41 17 23 27 22 0 0.796 1.000 1.000 515 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(10), DUSP1(3), IKBKAP(20), IKBKB(12), MAP3K1(24), NFKB1(10), NFKBIA(1), RELA(7), TNFAIP3(16), TRAF3(8), TRAF6(7) 15586811 118 79 112 31 28 13 11 26 40 0 0.323 1.000 1.000 516 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(4), CREM(6), FOS(2), JUN(6), MAPK3(3), OPRK1(19), POLR2A(27), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12) 11036855 111 79 106 32 27 19 16 19 30 0 0.169 1.000 1.000 517 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(11), CSF1(6), CSF3(3), HLA-DRA(7), HLA-DRB1(2), IFNA1(1), IFNB1(4), IFNG(3), IL10(4), IL11(3), IL12A(3), IL12B(3), IL13(4), IL15(2), IL1A(2), IL3(3), IL4(4), IL6(1), IL7(2), LTA(4), PDGFA(4), TGFB1(3), TGFB2(10), TGFB3(11), TNF(3) 11522223 103 79 95 34 26 12 12 26 27 0 0.631 1.000 1.000 518 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(9), ACAT2(6), ACOT11(6), ACYP1(2), ACYP2(3), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), ECHS1(3), EHHADH(5), ESCO1(13), ESCO2(11), FN3K(6), GCDH(8), HADHA(7), NAT6(4), PNPLA3(4), SH3GLB1(5), YOD1(2) 22179819 117 78 110 24 22 17 16 19 43 0 0.0666 1.000 1.000 519 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(5), CD2(5), CD3E(3), CD4(11), CXCR3(3), IFNG(3), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), JAK2(14), STAT4(14), TYK2(15) 12678267 103 78 98 40 18 14 17 26 27 1 0.874 1.000 1.000 520 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA3(6), PSMA4(4), PSMA5(1), PSMA6(9), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(2), PSMB6(5), PSMB7(1), PSMC2(5), PSMC3(10), PSMD1(15), PSMD11(5), PSMD12(7), PSMD13(2), PSMD2(19), PSMD6(6) 13803137 117 77 116 28 27 15 21 31 23 0 0.112 1.000 1.000 521 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(4), FOS(2), HRAS(2), JUN(6), MAP2K1(9), MAPK1(4), MAPK3(3), MYC(6), NFKB1(10), NFKBIA(1), PLCB1(24), PRKCA(9), RAF1(11), RELA(7), TNF(3) 13346305 101 76 95 25 25 15 10 26 25 0 0.0743 1.000 1.000 522 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(12), DLL1(17), FURIN(8), NOTCH1(51), PSEN1(7) 8182446 95 76 92 33 25 9 10 20 29 2 0.439 1.000 1.000 523 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(11), ESR1(14), GREB1(35), HSPB1(2), HSPB2(2), MTA1(13), MTA3(5), PDZK1(3), TUBA8(11) 9513617 97 75 93 33 32 15 13 18 19 0 0.258 1.000 1.000 524 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(18), KHK(2), LCT(32), MPI(3), PGM1(4), PYGL(14), PYGM(18), TPI1(3), TREH(3) 11661286 97 74 95 33 37 18 8 17 17 0 0.294 1.000 1.000 525 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(14), ESR2(10), ITPKA(2), PDE1A(10), PDE1B(8), PLCB1(24), PLCB2(9), PRL(3), TRH(5), VIP(9) 9528258 94 74 91 37 30 11 15 25 13 0 0.711 1.000 1.000 526 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(6), ACAD9(9), ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), ESCO1(13), ESCO2(11), NAT6(4), PNPLA3(4), SH3GLB1(5) 21268505 113 73 110 25 25 10 18 26 34 0 0.0820 1.000 1.000 527 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(10), HK1(18), HK2(15), HK3(13), IMPA1(8), IMPA2(2), ISYNA1(5), PGM1(4), PGM3(13), TGDS(7) 10076157 95 72 91 28 31 17 13 25 9 0 0.0844 1.000 1.000 528 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(5), CD28(2), CD3E(3), CD4(11), ICAM1(5), ITGAL(28), ITGB2(12), PTPRC(30), THY1(1) 9656065 97 72 88 43 20 9 11 31 26 0 0.934 1.000 1.000 529 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7) 11370599 106 71 94 30 24 10 14 27 31 0 0.317 1.000 1.000 530 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(7), ACOX3(14), ELOVL2(9), ELOVL5(4), ELOVL6(3), FADS1(3), FADS2(6), FASN(34), HADHA(7), HSD17B12(4), PECR(1), SCD(4) 12482580 99 71 90 39 33 11 12 16 27 0 0.731 1.000 1.000 531 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(6), FUT1(6), FUT2(2), FUT9(11), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(7), ST3GAL2(11), ST3GAL4(8), ST8SIA1(12) 8641063 83 70 80 30 34 7 7 27 8 0 0.487 1.000 1.000 532 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(4), GALNS(4), GLB1(9), GNS(10), GUSB(12), HEXA(2), HEXB(3), IDS(4), IDUA(5), LCT(32), NAGLU(11) 12420516 96 70 95 38 27 16 12 21 20 0 0.726 1.000 1.000 533 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(8), ICAM1(5), ITGA4(21), ITGAL(28), ITGB1(12), ITGB2(12), SELE(9), SELL(7) 10494981 102 70 96 37 28 8 13 28 25 0 0.459 1.000 1.000 534 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(5), CD28(2), CD3E(3), CD8A(4), ICAM1(5), ITGAL(28), ITGB2(12), PTPRC(30), THY1(1) 9188886 90 70 86 37 20 9 12 29 20 0 0.735 1.000 1.000 535 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), B4GALT7(9), HS3ST1(10), HS3ST2(12), HS3ST3A1(5), HS3ST3B1(5), XYLT1(14), XYLT2(46) 5623911 105 69 73 35 37 6 13 13 35 1 0.838 1.000 1.000 536 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), B4GALT7(9), HS3ST1(10), HS3ST2(12), HS3ST3A1(5), HS3ST3B1(5), XYLT1(14), XYLT2(46) 5623911 105 69 73 35 37 6 13 13 35 1 0.838 1.000 1.000 537 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(10), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), HEMK1(2), LCMT1(2), LCMT2(11), METTL2B(1), METTL6(5), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), WBSCR22(5) 12853614 106 69 100 24 23 16 14 21 31 1 0.0481 1.000 1.000 538 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(6), B3GALNT1(5), B3GALT5(2), FUT1(6), FUT2(2), FUT9(11), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(7), ST3GAL2(11), ST8SIA1(12) 9155760 82 68 78 36 32 7 7 26 10 0 0.830 1.000 1.000 539 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(6), DCXR(1), GUSB(12), RPE(6), UCHL1(3), UCHL3(4), UGDH(11), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2B15(6), UGT2B4(6) 15035227 106 68 100 25 23 11 20 25 27 0 0.0638 1.000 1.000 540 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(17), EGF(15), EGFR(24), HGS(6), RAB5A(4), TF(19), TFRC(4) 11038842 89 67 87 37 22 18 8 24 16 1 0.773 1.000 1.000 541 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(11), G6PD(6), GCLC(4), GCLM(4), GGT1(9), GPX5(2), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTM2(1), GSTM3(3), GSTM4(3), GSTM5(3), GSTO2(4), GSTP1(2), GSTZ1(2), IDH1(5), IDH2(8), MGST1(3), MGST2(3), MGST3(5), PGD(9) 15562251 98 67 94 31 25 20 9 23 21 0 0.392 1.000 1.000 542 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(10), HK1(18), HK2(15), HK3(13), IMPA1(8), PGM1(4), PGM3(13), TGDS(7) 8855295 88 67 85 26 27 17 13 22 9 0 0.114 1.000 1.000 543 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(10), MAPK14(3), MAPK8(7), NFKB1(10), RELA(7), TNFRSF13B(7), TNFRSF13C(4), TNFRSF17(1), TNFSF13(6), TNFSF13B(5), TRAF2(5), TRAF3(8), TRAF5(7), TRAF6(7) 12568537 87 67 85 19 15 18 6 22 25 1 0.111 1.000 1.000 544 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(18), CHAT(14), CHKA(2), PCYT1A(11), PDHA1(1), PDHA2(16), PEMT(1), SLC18A3(17) 5967727 80 66 79 42 31 8 8 25 8 0 0.932 1.000 1.000 545 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(13), DHCR7(10), FDFT1(5), FDPS(14), HMGCR(8), HMGCS1(2), IDI1(3), LSS(16), MVD(2), MVK(16), NSDHL(4), PMVK(1), SQLE(10) 11359976 104 65 91 27 23 9 7 28 37 0 0.400 1.000 1.000 546 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(14), FADS2(6), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11) 8876660 83 65 74 25 32 6 9 26 10 0 0.309 1.000 1.000 547 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(22), JAK2(14), JAK3(18), MAPK1(4), MAPK3(3), STAT3(9), TYK2(15) 10170467 85 65 81 30 16 12 13 20 21 3 0.811 1.000 1.000 548 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(3), CD4(11), FYN(10), HLA-DRA(7), HLA-DRB1(2), LCK(5), PTPRC(30), ZAP70(16) 7819509 84 64 77 36 22 9 11 28 14 0 0.905 1.000 1.000 549 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(4), CAMK1G(10), HDAC9(23), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), MYOD1(8), YWHAH(3) 6863568 75 63 73 30 18 7 9 18 23 0 0.737 1.000 1.000 550 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(11), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLRMT(17) 11604728 87 63 84 31 28 12 16 15 16 0 0.443 1.000 1.000 551 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(7), AKR1D1(4), CYP11A1(8), CYP11B1(19), CYP11B2(12), CYP17A1(8), CYP21A2(7), HSD11B1(5), HSD11B2(5), HSD3B1(6), HSD3B2(5) 8171657 86 62 84 31 28 13 7 27 11 0 0.595 1.000 1.000 552 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(3), CALM3(2), CAMK1(4), CAMK1G(10), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), CAMKK1(5), CAMKK2(6), CREB1(4), SYT1(8) 9973508 81 62 79 25 22 9 15 16 19 0 0.274 1.000 1.000 553 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(7), AKR1D1(4), CYP11A1(8), CYP11B1(19), CYP11B2(12), CYP17A1(8), CYP21A2(7), HSD11B1(5), HSD11B2(5), HSD3B1(6), HSD3B2(5) 8171657 86 62 84 31 28 13 7 27 11 0 0.595 1.000 1.000 554 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(8), ICAM1(5), ITGAL(28), ITGAM(13), ITGB2(12), SELE(9), SELL(7) 9029442 82 62 79 36 27 6 8 21 20 0 0.782 1.000 1.000 555 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(7), CBS(9), CTH(3), GGT1(9), MARS(10), MARS2(6), MAT1A(8), MAT2B(5), PAPSS1(6), PAPSS2(9), SCLY(6), SEPHS1(7) 10690313 85 62 82 30 25 11 15 14 20 0 0.404 1.000 1.000 556 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA3(6), PSMA4(4), PSMA5(1), PSMA6(9), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(2), PSMB6(5), PSMB7(1), PSMC3(10), PSMD14(2), RPN1(7), RPN2(9), UBE2A(1), UBE3A(8) 11226728 85 61 84 22 18 8 20 22 17 0 0.152 1.000 1.000 557 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(4), IL13RA1(6), IL13RA2(10), IL4R(10), JAK1(22), JAK2(14), TYK2(15) 9045319 81 61 78 24 16 12 13 16 21 3 0.506 1.000 1.000 558 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(4), IL13RA1(6), IL13RA2(10), IL4R(10), JAK1(22), JAK2(14), TYK2(15) 9045319 81 61 78 24 16 12 13 16 21 3 0.506 1.000 1.000 559 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(14), AGT(5), AGTR1(1), AGTR2(6), BDKRB2(3), KNG1(13), NOS3(20), REN(9) 8458258 71 60 67 24 16 9 9 13 24 0 0.545 1.000 1.000 560 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(9), ACO2(12), AFMID(5), CS(1), GRHPR(4), HAO1(6), HAO2(9), HYI(2), MDH1(5), MDH2(2), MTHFD1(9), MTHFD1L(12), MTHFD2(3) 11526494 79 60 78 24 21 18 9 17 14 0 0.212 1.000 1.000 561 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL1(3), FOSL2(11), IFNAR1(9), IFNAR2(4), IFNB1(4), MAPK8(7), NFKB1(10), RELA(7), TNFRSF11A(5), TNFSF11(5), TRAF6(7) 9530903 74 60 73 23 16 12 9 18 19 0 0.380 1.000 1.000 562 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(12), CAPN1(8), CAPNS1(6), CAPNS2(3), CDK5(3), CDK5R1(6), CSNK1A1(7), CSNK1D(5), GSK3B(9), MAPT(12), PPP2CA(5) 8035816 76 59 74 24 20 17 9 16 14 0 0.212 1.000 1.000 563 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(2), MMP14(11), MMP2(13), MMP9(23), RECK(10), TIMP1(1), TIMP2(1), TIMP3(12), TIMP4(3) 6539438 76 59 73 33 26 15 3 17 13 2 0.721 1.000 1.000 564 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(10), FDFT1(5), FDPS(14), HMGCR(8), IDI1(3), LSS(16), MVD(2), MVK(16), NQO1(4), NQO2(4), PMVK(1), SQLE(10), VKORC1(2) 9523954 95 58 83 24 22 11 8 25 29 0 0.233 1.000 1.000 565 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(11), CARS2(9), CDO1(3), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHAL6A(4), LDHAL6B(7), LDHB(5), LDHC(1), MPST(3), SDS(5), SULT1B1(6), SULT1C2(4), SULT1C4(4), SULT4A1(1) 10856421 78 57 78 26 23 17 7 17 14 0 0.381 1.000 1.000 566 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(22), EIF2AK4(14), EIF2B5(11), EIF2S1(3), EIF2S2(3), EIF2S3(3), EIF5(6), GSK3B(9), PPP1CA(3) 9914591 74 56 73 17 15 5 14 23 16 1 0.139 1.000 1.000 567 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(8), CDKN1A(7), EPO(3), EPOR(5), GRIN1(11), HIF1A(10), JAK2(14), NFKB1(10), NFKBIA(1), RELA(7), SOD2(2) 10945448 78 56 76 23 16 21 7 12 21 1 0.237 1.000 1.000 568 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(9), ACO2(12), CS(1), GRHPR(4), HAO1(6), HAO2(9), HYI(2), MDH1(5), MDH2(2), MTHFD1(9), MTHFD1L(12), MTHFD2(3) 10994877 74 56 73 24 19 17 9 17 12 0 0.321 1.000 1.000 569 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(6), EGR1(14), HRAS(2), KLK2(2), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), NGFR(9), RAF1(11) 7112670 69 55 63 25 24 10 8 16 11 0 0.393 1.000 1.000 570 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(8), GSS(2), NFKB1(10), NOX1(8), RELA(7), TNF(3), XDH(32) 8571745 70 55 69 20 12 15 8 21 14 0 0.268 1.000 1.000 571 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(6), CHST11(4), CHST12(7), CHST13(6), PAPSS1(6), PAPSS2(9), SULT1A1(10), SULT1A2(8), SULT1E1(3), SULT2A1(4), SULT2B1(2), SUOX(8) 7959828 73 54 72 29 29 12 7 14 11 0 0.569 1.000 1.000 572 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(6), IARS(15), LARS(13), LARS2(12), PDHA1(1), PDHA2(16), PDHB(4) 8570534 67 54 66 26 9 9 12 23 14 0 0.831 1.000 1.000 573 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(11), ENO1(4), GPI(6), HK1(18), PFKL(9), PGAM1(1), PGK1(5), PKLR(12), TPI1(3) 7996159 69 53 69 29 21 17 6 16 9 0 0.529 1.000 1.000 574 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(6), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), HSD3B7(9), PON1(4), PON2(5), PON3(9), RDH11(1), RDH12(3), RDH13(8) 7706181 68 53 66 24 20 9 8 20 11 0 0.570 1.000 1.000 575 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(8), ADSS(6), IMPDH1(7), MTHFD2(3), NME2(3), OAZ1(3), POLB(8), POLD1(18), POLG(10), PRPS2(5), RRM1(5), SRM(4) 10903143 80 52 79 25 25 17 7 14 17 0 0.319 1.000 1.000 576 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(12), BMPR1A(13), BMPR1B(13), BMPR2(24) 5342297 62 51 60 16 8 4 11 12 25 2 0.508 1.000 1.000 577 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(12), CS(1), FH(4), IDH2(8), MDH1(5), OGDH(13), SDHA(15), SUCLA2(3) 8134665 61 50 57 19 20 11 4 8 18 0 0.348 1.000 1.000 578 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(4), IFNG(3), IL10(4), IL12A(3), IL12B(3), IL13(4), IL15(2), IL16(21), IL18(1), IL1A(2), IL3(3), IL4(4), IL6(1), LTA(4), TNF(3) 8513653 63 49 63 23 13 9 8 20 13 0 0.573 1.000 1.000 579 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(5), APAF1(11), BCL2(4), CASP3(2), CASP9(4), DAXX(14), FAS(3), FASLG(6), HSPB1(2), HSPB2(2), IL1A(2), MAPKAPK2(4), MAPKAPK3(5), TNF(3) 9716105 67 49 66 28 20 8 6 17 16 0 0.752 1.000 1.000 580 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(9), FARSA(8), FARSB(4), GOT1(3), GOT2(2), PAH(10), TAT(7), YARS(9), YARS2(4) 7507130 56 48 56 21 15 8 6 16 11 0 0.709 1.000 1.000 581 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(7), ALPL(10), ALPP(16), ALPPL2(6), FPGS(8), GCH1(1), GGH(2), SPR(3) 5695103 53 46 52 31 26 6 1 10 10 0 0.853 1.000 1.000 582 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(11), CKM(2), EIF4E(2), FBL(8), GPT(8), LDHA(7), LDHB(5), LDHC(1), MAPK14(3), NCL(12) 7771460 59 46 58 22 14 13 2 16 14 0 0.770 1.000 1.000 583 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(9), TAX1BP3(1), UBE2A(1), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2D3(3), UBE2E1(4), UBE2E3(3), UBE2G2(3), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(5), UBE2L3(1), UBE2L6(2), UBE2M(2), UBE2N(3), UBE2S(3), UBE3A(8) 9104453 58 46 58 18 19 10 4 14 11 0 0.235 1.000 1.000 584 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(4), GRB2(4), HRAS(2), PTK2B(20), SHC1(7), SOS1(12), SRC(5) 7565577 54 45 53 15 16 6 4 17 11 0 0.368 1.000 1.000 585 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(7), ADORA2A(7), ADORA2B(4), ADORA3(9), LTB4R(2), P2RY1(5), P2RY2(5), P2RY6(12) 5013676 51 45 50 26 26 2 2 14 7 0 0.817 1.000 1.000 586 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(6), CYP11A1(8), CYP11B2(12), CYP17A1(8), HSD11B1(5), HSD11B2(5), HSD3B1(6), HSD3B2(5) 5952663 55 44 54 25 15 4 6 20 10 0 0.927 1.000 1.000 587 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(3), B3GALT2(10), B3GALT5(2), B3GNT5(12), FUT1(6), FUT2(2), FUT3(6), ST3GAL3(3), ST3GAL4(8) 6180637 52 44 49 19 20 5 2 12 13 0 0.770 1.000 1.000 588 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(4), NFKB1(10), NFKBIA(1), PLCB1(24), PRKCA(9), RELA(7) 7090946 55 44 53 16 13 9 4 14 15 0 0.337 1.000 1.000 589 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(9), ACAT2(6), BDH1(8), BDH2(4), HMGCS1(2), HMGCS2(6), OXCT1(10), OXCT2(7) 6191880 52 43 49 17 12 10 4 11 15 0 0.621 1.000 1.000 590 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(4), ENO2(6), ENO3(4), FARS2(9), GOT1(3), GOT2(2), PAH(10), TAT(7), YARS(9) 7128611 54 42 54 20 15 11 6 13 9 0 0.479 1.000 1.000 591 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(11), CLOCK(8), CRY1(4), CRY2(9), CSNK1E(10), PER1(11) 7273230 53 41 51 19 19 9 4 6 15 0 0.713 1.000 1.000 592 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(9), AASDH(15), AASDHPPT(1), AASS(13), KARS(9) 5976290 47 41 46 15 8 12 8 9 10 0 0.500 1.000 1.000 593 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(8), CDKN1A(7), CHEK1(7), NEK1(9), WEE1(7) 6147789 46 40 46 13 9 9 4 12 12 0 0.531 1.000 1.000 594 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(14), GOT1(3), GOT2(2), TAT(7), TYR(18) 4029877 44 39 37 15 9 5 4 14 11 1 0.789 1.000 1.000 595 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA3(6), PSMA4(4), PSMA5(1), PSMA6(9), PSMA7(4), PSMB1(2), PSMB10(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(2), PSMB6(5), PSMB7(1), PSMB8(5), PSMB9(2) 7526974 57 39 57 20 16 6 11 13 11 0 0.568 1.000 1.000 596 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(5), GPD2(10), NDUFA1(2), SDHA(15), SDHB(4), SDHC(2), SDHD(3), UQCRC1(3) 5652740 44 38 44 16 11 5 7 11 10 0 0.511 1.000 1.000 597 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(8), FUT1(6), FUT2(2), FUT9(11), GCNT2(1), ST8SIA1(12) 5272905 40 37 38 16 14 3 3 16 4 0 0.638 1.000 1.000 598 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(13), CS(1), MDH1(5), ME1(2), PC(19), PDHA1(1), SLC25A1(4), SLC25A11(2) 7989494 47 37 46 21 17 6 7 11 6 0 0.811 1.000 1.000 599 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(3), NFYC(4), RB1(22), SP1(6), SP3(7) 5711323 43 37 42 11 6 5 6 9 17 0 0.445 1.000 1.000 600 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(3), DAG1(14), GNAQ(4), ITPKA(2), ITPKB(20) 5094914 47 36 46 19 16 2 7 11 11 0 0.776 1.000 1.000 601 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(6), PAPSS1(6), PAPSS2(9), SULT1A2(8), SULT1E1(3), SULT2A1(4), SUOX(8) 5215240 44 36 44 12 12 10 5 10 7 0 0.278 1.000 1.000 602 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(11), CD8A(4), CSF1(6), CSF3(3), EPO(3), IL11(3), IL3(3), IL4(4), IL6(1), IL7(2) 5280223 40 35 34 16 11 4 4 7 14 0 0.870 1.000 1.000 603 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(4), NDUFA4(1), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(8), NDUFS2(8), NDUFV1(6), NDUFV2(2) 6029551 44 34 43 11 9 8 6 10 11 0 0.341 1.000 1.000 604 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(5), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), RAC1(2), WASF1(11), WASL(7) 7034842 44 33 43 24 10 5 4 11 14 0 0.989 1.000 1.000 605 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(6), CYP2E1(8), NR1I3(3), PTGS1(15), PTGS2(7) 4603634 39 30 39 13 14 4 4 9 7 1 0.450 1.000 1.000 606 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(6), PLCD1(7), PRKCA(9), TGM2(12) 4290963 34 29 33 14 17 4 0 8 5 0 0.585 1.000 1.000 607 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(11), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHB(5), LDHC(1), MPST(3) 5886360 35 28 35 15 12 9 5 4 5 0 0.726 1.000 1.000 608 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(6), EPHX2(5), HSD3B7(9), RDH11(1), RDH12(3), RDH13(8) 4145738 32 28 31 14 10 6 3 7 6 0 0.743 1.000 1.000 609 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(6), FUT2(2), FUT3(6), FUT5(4), FUT6(8), ST3GAL3(3) 4388646 29 26 29 17 14 4 2 6 3 0 0.908 1.000 1.000 610 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(7), COQ5(3), COQ6(4), COQ7(4), NDUFA12(2), NDUFA13(3), NDUFB11(2) 3517511 25 23 25 10 7 2 4 5 7 0 0.800 1.000 1.000 611 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(11), HLA-DRA(7), HLA-DRB1(2) 2034391 22 22 17 10 5 2 2 4 9 0 0.956 1.000 1.000 612 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(10), ALDH1A2(9), RDH5(3) 3335957 22 22 22 10 6 2 1 7 6 0 0.876 1.000 1.000 613 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(5), CD28(2), CD3E(3), CD4(11) 2753965 21 21 16 10 3 1 4 5 8 0 0.968 1.000 1.000 614 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(5), RAB11A(3), RAB1A(1), RAB27A(6), RAB3A(1), RAB4A(2), RAB5A(4) 3654573 22 18 20 19 8 2 4 4 4 0 0.990 1.000 1.000 615 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(7), PGLYRP2(8) 1536652 15 14 15 7 8 2 3 2 0 0 0.726 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 438523 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000