E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.027 0.074 -9999.0 0.0 -0.394 17.0 17.0 KLHL20 -0.013 0.04 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 -0.011 0.104 -9999.0 0.0 -0.462 30.0 30.0 Rac1/GDP 0.051 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.028 0.069 -9999.0 0.0 -0.391 15.0 15.0 AP1M1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.008 0.057 -9999.0 0.0 -0.799 3.0 3.0 RAP1A 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.011 0.033 -9999.0 0.0 -0.799 1.0 1.0 CDC42/GTP -0.005 0.031 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.012 0.032 -9999.0 0.0 -0.197 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.025 0.045 -9999.0 0.0 -0.48 1.0 1.0 RAPGEF1 0.041 0.059 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.063 -9999.0 0.0 -0.408 14.0 14.0 CRK 0.035 0.063 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin -0.034 0.123 -9999.0 0.0 -0.528 32.0 32.0 alphaE/beta7 Integrin 0.018 0.013 -9999.0 0.0 -0.311 1.0 1.0 IQGAP1 0.011 0.033 -9999.0 0.0 -0.799 1.0 1.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.021 0.036 -9999.0 0.0 -0.487 3.0 3.0 DLG1 0.029 0.067 -9999.0 0.0 -0.39 14.0 14.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.004 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.001 0.103 -9999.0 0.0 -0.497 22.0 22.0 PI3K -0.005 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.023 0.148 -9999.0 0.0 -0.611 32.0 32.0 TIAM1 -0.023 0.155 -9999.0 0.0 -0.664 31.0 31.0 E-cadherin(dimer)/Ca2+ -0.006 0.036 -9999.0 0.0 -0.455 1.0 1.0 AKT1 -0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.002 0.07 -9999.0 0.0 -0.451 14.0 14.0 RhoA/GDP 0.051 0.046 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.031 0.043 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GDP 0.051 0.046 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.003 0.073 -9999.0 0.0 -0.263 32.0 32.0 ITGB7 0.012 0.019 -9999.0 0.0 -0.451 1.0 1.0 RAC1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.025 0.044 -9999.0 0.0 -0.48 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.006 0.037 -9999.0 0.0 -0.462 1.0 1.0 mol:GDP 0.048 0.051 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 -0.001 0.022 -9999.0 0.0 -0.535 1.0 1.0 JUP -0.031 0.182 -9999.0 0.0 -0.799 32.0 32.0 p120 catenin/RhoA/GDP -0.006 0.035 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 -0.001 0.022 -9999.0 0.0 -0.535 1.0 1.0 PIP5K1C/AP1M1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.023 0.044 -9999.0 0.0 -0.253 10.0 10.0 NME1 0.008 0.057 -9999.0 0.0 -0.799 3.0 3.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.029 0.067 -9999.0 0.0 -0.39 14.0 14.0 regulation of cell-cell adhesion -0.005 0.027 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.006 0.017 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.006 0.036 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.029 0.104 -9999.0 0.0 -0.449 32.0 32.0 CCND1 0.026 0.054 -9999.0 0.0 -0.32 10.0 10.0 VAV2 0.038 0.065 -9999.0 0.0 -9999.0 0.0 0.0 RAP1/GDP 0.043 0.047 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.029 0.065 -9999.0 0.0 -0.378 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.011 0.111 -9999.0 0.0 -0.424 33.0 33.0 E-cadherin/beta catenin -0.007 0.048 -9999.0 0.0 -0.317 14.0 14.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.029 0.067 -9999.0 0.0 -0.39 14.0 14.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.02 0.063 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin -0.007 0.044 -9999.0 0.0 -0.528 1.0 1.0 ITGAE 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.011 0.064 -9999.0 0.0 -0.416 14.0 14.0