Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.099 0.283 -9999.0 0.0 -0.648 101.0 101.0 IHH -0.1 0.225 -9999.0 0.0 -0.535 122.0 122.0 SHH Np/Cholesterol/GAS1 -0.046 0.132 -9999.0 0.0 -0.511 19.0 19.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.045 0.131 0.507 19.0 -9999.0 0.0 19.0 SMO/beta Arrestin2 -0.08 0.228 -9999.0 0.0 -0.563 79.0 79.0 SMO -0.09 0.24 -9999.0 0.0 -0.573 90.0 90.0 AKT1 -0.019 0.107 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.037 0.144 -9999.0 0.0 -0.456 63.0 63.0 ADRBK1 0.01 0.047 -9999.0 0.0 -0.799 2.0 2.0 heart looping -0.089 0.236 -9999.0 0.0 -0.563 90.0 90.0 STIL -0.111 0.234 -9999.0 0.0 -0.526 103.0 103.0 DHH N/PTCH2 -0.045 0.177 -9999.0 0.0 -0.493 74.0 74.0 DHH N/PTCH1 -0.068 0.196 -9999.0 0.0 -0.485 76.0 76.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.008 0.094 -9999.0 0.0 -0.451 26.0 26.0 PTHLH -0.16 0.393 -9999.0 0.0 -0.956 102.0 102.0 determination of left/right symmetry -0.089 0.236 -9999.0 0.0 -0.563 90.0 90.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.157 0.387 -9999.0 0.0 -0.941 102.0 102.0 IHH N/Hhip -0.153 0.22 -9999.0 0.0 -0.414 223.0 223.0 DHH N/Hhip -0.095 0.167 -9999.0 0.0 -0.33 195.0 195.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.089 0.236 -9999.0 0.0 -0.563 90.0 90.0 pancreas development -0.129 0.212 -9999.0 0.0 -0.45 182.0 182.0 HHAT 0.005 0.059 -9999.0 0.0 -0.451 10.0 10.0 PI3K 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.04 0.16 -9999.0 0.0 -0.502 61.0 61.0 somite specification -0.089 0.236 -9999.0 0.0 -0.563 90.0 90.0 SHH Np/Cholesterol/PTCH1 -0.078 0.208 -9999.0 0.0 -0.498 89.0 89.0 SHH Np/Cholesterol/PTCH2 -0.056 0.161 -9999.0 0.0 -0.502 50.0 50.0 SHH Np/Cholesterol/Megalin -0.074 0.174 -9999.0 0.0 -0.496 68.0 68.0 SHH -0.031 0.126 -9999.0 0.0 -0.327 89.0 89.0 catabolic process -0.072 0.205 -9999.0 0.0 -0.499 77.0 77.0 SMO/Vitamin D3 -0.087 0.231 -9999.0 0.0 -0.541 96.0 96.0 SHH Np/Cholesterol/Hhip -0.092 0.16 -9999.0 0.0 -0.468 51.0 51.0 LRP2 -0.075 0.248 -9999.0 0.0 -0.799 63.0 63.0 receptor-mediated endocytosis -0.137 0.211 -9999.0 0.0 -0.581 76.0 76.0 SHH Np/Cholesterol/BOC -0.043 0.125 -9999.0 0.0 -0.522 12.0 12.0 SHH Np/Cholesterol/CDO -0.024 0.11 -9999.0 0.0 -0.472 12.0 12.0 mesenchymal cell differentiation 0.092 0.159 0.464 51.0 -9999.0 0.0 51.0 mol:Vitamin D3 -0.076 0.21 -9999.0 0.0 -0.501 89.0 89.0 IHH N/PTCH2 -0.101 0.215 -9999.0 0.0 -0.475 118.0 118.0 CDON -0.001 0.09 -9999.0 0.0 -0.543 15.0 15.0 IHH N/PTCH1 -0.072 0.207 -9999.0 0.0 -0.505 77.0 77.0 Megalin/LRPAP1 -0.049 0.193 -9999.0 0.0 -0.611 63.0 63.0 PTCH2 -0.051 0.215 -9999.0 0.0 -0.763 49.0 49.0 SHH Np/Cholesterol -0.037 0.091 -9999.0 0.0 -0.475 5.0 5.0 PTCH1 -0.072 0.206 -9999.0 0.0 -0.501 77.0 77.0 HHIP -0.129 0.213 -9999.0 0.0 -0.451 182.0 182.0