Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.024 0.037 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.006 0.036 -9999.0 0.0 -0.45 1.0 1.0 CYFIP2 -0.011 0.104 -9999.0 0.0 -0.462 30.0 30.0 ENAH 0.053 0.045 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.025 0.164 -9999.0 0.0 -0.709 31.0 31.0 EPHA2 0.006 0.074 -9999.0 0.0 -0.799 5.0 5.0 MYO6 0.03 0.039 -9999.0 0.0 -0.427 1.0 1.0 CTNNB1 0.011 0.033 -9999.0 0.0 -0.799 1.0 1.0 ABI1/Sra1/Nap1 -0.013 0.058 -9999.0 0.0 -0.528 1.0 1.0 AQP5 -0.146 0.173 -9999.0 0.0 -0.577 4.0 4.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.03 0.038 -9999.0 0.0 -0.42 1.0 1.0 regulation of calcium-dependent cell-cell adhesion 0.019 0.066 -9999.0 0.0 -0.492 3.0 3.0 EGF -0.115 0.291 -9999.0 0.0 -0.788 94.0 94.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.034 0.099 -9999.0 0.0 -0.577 1.0 1.0 cortical microtubule organization -0.006 0.036 -9999.0 0.0 -0.45 1.0 1.0 GO:0000145 0.028 0.037 -9999.0 0.0 -0.401 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.006 0.036 -9999.0 0.0 -0.456 1.0 1.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.008 0.044 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.051 -9999.0 0.0 -0.48 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.039 0.041 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.03 0.039 -9999.0 0.0 -0.427 1.0 1.0 ARF6/GTP -0.004 0.044 -9999.0 0.0 -0.442 6.0 6.0 CDH1 0.002 0.07 -9999.0 0.0 -0.451 14.0 14.0 EGFR/EGFR/EGF/EGF -0.087 0.175 -9999.0 0.0 -0.72 9.0 9.0 RhoA/GDP -0.005 0.033 -9999.0 0.0 -0.422 1.0 1.0 actin cytoskeleton organization 0.035 0.038 -9999.0 0.0 -0.392 1.0 1.0 IGF-1R heterotetramer 0.007 0.063 -9999.0 0.0 -0.658 5.0 5.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.063 -9999.0 0.0 -0.66 5.0 5.0 IGF1 -0.06 0.199 -9999.0 0.0 -0.561 76.0 76.0 DIAPH1 -0.026 0.114 -9999.0 0.0 -0.529 29.0 29.0 Wnt receptor signaling pathway 0.006 0.036 0.45 1.0 -9999.0 0.0 1.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.008 0.044 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.035 0.039 -9999.0 0.0 -0.402 1.0 1.0 EFNA1 0.011 0.033 -9999.0 0.0 -0.799 1.0 1.0 LPP 0.033 0.055 -9999.0 0.0 -0.833 1.0 1.0 Ephrin A1/EPHA2 -0.009 0.051 -9999.0 0.0 -0.414 6.0 6.0 SEC6/SEC8 -0.004 0.028 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.019 0.067 -9999.0 0.0 -0.501 3.0 3.0 HGF/MET -0.031 0.103 -9999.0 0.0 -0.433 31.0 31.0 HGF -0.011 0.117 -9999.0 0.0 -0.548 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.024 0.037 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.065 0.045 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.031 0.054 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.03 0.039 -9999.0 0.0 -0.427 1.0 1.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.028 0.047 -9999.0 0.0 -0.432 3.0 3.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.006 0.036 -9999.0 0.0 -0.45 1.0 1.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.03 0.039 -9999.0 0.0 -0.427 1.0 1.0 PIP5K1C 0.03 0.039 -9999.0 0.0 -0.427 1.0 1.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.05 0.048 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.045 0.055 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.04 0.106 -9999.0 0.0 -0.618 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.019 0.157 -9999.0 0.0 -0.784 24.0 24.0 PLEKHA7 0.028 0.045 -9999.0 0.0 -0.427 1.0 1.0 mol:GTP -0.005 0.047 -9999.0 0.0 -0.476 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.053 0.035 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.024 0.037 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.035 0.038 -9999.0 0.0 -0.392 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.024 0.037 -9999.0 0.0 -9999.0 0.0 0.0