Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.309 0.381 -9999.0 0.0 -0.819 37.0 37.0 IHH -0.26 0.357 -9999.0 0.0 -0.677 55.0 55.0 SHH Np/Cholesterol/GAS1 -0.118 0.213 -9999.0 0.0 -0.542 29.0 29.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.117 0.212 0.538 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.202 0.239 -9999.0 0.0 -0.838 9.0 9.0 SMO -0.205 0.266 -9999.0 0.0 -0.643 28.0 28.0 AKT1 -0.076 0.121 -9999.0 0.0 -0.394 5.0 5.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.094 0.232 -9999.0 0.0 -0.515 30.0 30.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.202 0.261 -9999.0 0.0 -0.63 28.0 28.0 STIL -0.235 0.259 -9999.0 0.0 -0.754 16.0 16.0 DHH N/PTCH2 -0.063 0.178 -9999.0 0.0 -0.758 7.0 7.0 DHH N/PTCH1 -0.242 0.257 -9999.0 0.0 -0.633 34.0 34.0 PIK3CA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.061 0.202 -9999.0 0.0 -0.531 20.0 20.0 PTHLH -0.394 0.514 -9999.0 0.0 -1.192 37.0 37.0 determination of left/right symmetry -0.202 0.261 -9999.0 0.0 -0.63 28.0 28.0 PIK3R1 0.005 0.072 -9999.0 0.0 -0.875 1.0 1.0 skeletal system development -0.386 0.502 -9999.0 0.0 -1.165 37.0 37.0 IHH N/Hhip -0.345 0.379 -9999.0 0.0 -0.747 61.0 61.0 DHH N/Hhip -0.229 0.297 -9999.0 0.0 -0.71 36.0 36.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.202 0.261 -9999.0 0.0 -0.63 28.0 28.0 pancreas development -0.232 0.355 -9999.0 0.0 -0.665 54.0 54.0 HHAT 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.005 0.055 -9999.0 0.0 -0.68 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.019 0.13 -9999.0 0.0 -0.493 9.0 9.0 somite specification -0.202 0.261 -9999.0 0.0 -0.63 28.0 28.0 SHH Np/Cholesterol/PTCH1 -0.268 0.26 -9999.0 0.0 -0.64 33.0 33.0 SHH Np/Cholesterol/PTCH2 -0.112 0.213 -9999.0 0.0 -0.548 28.0 28.0 SHH Np/Cholesterol/Megalin -0.259 0.282 -9999.0 0.0 -0.596 54.0 54.0 SHH -0.112 0.267 -9999.0 0.0 -0.681 26.0 26.0 catabolic process -0.214 0.265 -9999.0 0.0 -0.608 34.0 34.0 SMO/Vitamin D3 -0.247 0.285 -9999.0 0.0 -0.82 16.0 16.0 SHH Np/Cholesterol/Hhip -0.242 0.313 -9999.0 0.0 -0.637 51.0 51.0 LRP2 -0.267 0.35 -9999.0 0.0 -0.611 67.0 67.0 receptor-mediated endocytosis -0.341 0.29 -9999.0 0.0 -0.81 30.0 30.0 SHH Np/Cholesterol/BOC -0.158 0.245 -9999.0 0.0 -0.579 34.0 34.0 SHH Np/Cholesterol/CDO -0.107 0.21 -9999.0 0.0 -0.548 27.0 27.0 mesenchymal cell differentiation 0.24 0.309 0.63 51.0 -9999.0 0.0 51.0 mol:Vitamin D3 -0.256 0.277 -9999.0 0.0 -0.641 33.0 33.0 IHH N/PTCH2 -0.177 0.253 -9999.0 0.0 -0.647 30.0 30.0 CDON 0.003 0.079 -9999.0 0.0 -0.629 2.0 2.0 IHH N/PTCH1 -0.218 0.269 -9999.0 0.0 -0.618 34.0 34.0 Megalin/LRPAP1 -0.202 0.265 -9999.0 0.0 -0.68 31.0 31.0 PTCH2 -0.006 0.111 -9999.0 0.0 -0.629 4.0 4.0 SHH Np/Cholesterol -0.104 0.21 -9999.0 0.0 -0.556 26.0 26.0 PTCH1 -0.215 0.267 -9999.0 0.0 -0.61 34.0 34.0 HHIP -0.233 0.356 -9999.0 0.0 -0.666 54.0 54.0