rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 AKT1(5), AKT2(1), AKT3(1), ARRB1(1), ARRB2(1), BRAF(291), CACNA1A(2), CACNA1B(3), CACNA1C(2), CACNA1D(4), CACNA1E(5), CACNA1G(3), CACNA1H(1), CACNA1S(1), CACNA2D1(5), CACNA2D3(1), CACNA2D4(2), CACNB3(1), CACNG7(1), CDC42(1), DUSP5(1), DUSP7(1), ECSIT(2), FGF20(1), FGF5(1), FGF7(1), FGFR2(1), FLNA(1), FLNC(4), HRAS(17), IL1R1(2), JUN(1), KRAS(5), MAP2K1(1), MAP2K6(1), MAP3K1(3), MAP3K3(3), MAP3K6(1), MAP3K8(1), MAP4K4(1), MAPK10(1), MAPK8IP2(1), MAPKAPK3(1), MYC(1), NF1(2), NFATC4(3), NRAS(40), PDGFRB(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PTPRR(2), RAP1A(1), RASA1(2), RASGRF2(2), RASGRP1(1), RPS6KA1(1), RPS6KA4(1), SOS1(2), SOS2(2), TAOK2(2), TAOK3(1), TGFBR1(1), TGFBR2(1), TNFRSF1A(1), TP53(4) 210566400 459 378 114 39 20 26 60 330 23 0 <1.00e-15 <1.00e-15 <6.84e-14 2 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(291), CACNA1A(2), CRH(1), CRHR1(1), GNAS(3), GRIA1(1), GRIA2(2), GRID2(1), GRM1(3), GUCY1A3(1), HRAS(17), IGF1R(3), ITPR1(2), ITPR2(6), KRAS(5), LYN(1), MAP2K1(1), NOS1(1), NPR1(2), NRAS(40), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PPP2R1A(3), PPP2R1B(1), PPP2R2B(1), PRKG1(1), RYR1(8) 81240079 406 368 61 13 15 8 52 323 8 0 <1.00e-15 <1.00e-15 <6.84e-14 3 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY8(1), BRAF(291), CACNA1C(2), CALML6(1), CAMK2A(1), CAMK2B(1), CREBBP(1), GRIA1(1), GRIA2(2), GRIN2A(2), GRIN2B(4), GRIN2D(3), GRM1(3), HRAS(17), ITPR1(2), ITPR2(6), KRAS(5), MAP2K1(1), NRAS(40), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), RAP1A(1), RPS6KA1(1) 73321784 390 363 47 14 12 7 51 312 8 0 <1.00e-15 <1.00e-15 <6.84e-14 4 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTG1(1), AKT1(5), AKT2(1), AKT3(1), BAD(1), BRAF(291), CDC42(1), COL11A1(1), COL11A2(2), COL1A1(1), COL2A1(1), COL3A1(2), COL4A1(3), COL4A2(2), COL4A4(2), COL4A6(1), COL5A1(4), COL5A3(8), COL6A2(3), COL6A3(2), COL6A6(3), CTNNB1(2), ERBB2(1), FARP2(1), FIGF(1), FLNA(1), FLNC(4), FN1(3), FYN(1), HRAS(17), IGF1R(3), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), ITGAV(1), ITGB1(2), ITGB3(1), ITGB8(1), JUN(1), KDR(2), LAMA2(1), LAMA3(3), LAMA4(4), LAMA5(2), LAMB1(1), LAMB2(1), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), MAP2K1(1), MAPK10(1), MET(2), MYLK(4), PAK3(2), PAK7(2), PDGFRB(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PTEN(2), RAP1A(1), RAPGEF1(2), RELN(2), SHC1(1), SOS1(2), SOS2(2), SRC(2), THBS1(1), THBS2(2), THBS3(1), THBS4(1), TLN1(1), TLN2(3), TNC(1), TNN(1), TNR(3), TNXB(3), VAV2(1), VCL(2), VEGFA(1), VTN(1), VWF(1), ZYX(1) 273450375 471 354 166 55 29 34 29 351 27 1 4.12e-11 <1.00e-15 <6.84e-14 5 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(291), ERBB2(1), ERBB4(3), ETS1(2), KRAS(5), MAP2K1(1), NOTCH2(1), NOTCH3(1), NOTCH4(4), PIWIL1(1), PIWIL2(2), SOS1(2), SOS2(2) 38572470 316 301 26 11 2 4 7 300 3 0 2.66e-15 <1.00e-15 <6.84e-14 6 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(5), APC(3), BRAF(291), CAMP(1), ITPR1(2), ITPR2(6), KCNJ9(1), MAPK10(1), PHKA2(3), PIK3CA(3), PIK3CD(2), PIK3R1(2), PITX2(2), SRC(2) 39418229 324 301 34 8 7 5 2 302 8 0 <1.00e-15 <1.00e-15 <6.84e-14 7 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(5), AKT2(1), AKT3(1), BRAF(291), ITPR1(2), ITPR2(6), KCNJ9(1), PIK3CB(1), PITX2(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), SHC1(1), SOS1(2), SOS2(2), SRC(2) 43042654 321 299 31 6 8 7 3 300 3 0 <1.00e-15 <1.00e-15 <6.84e-14 8 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(5), AKT2(1), AKT3(1), BRAF(291), DDIT4(1), FIGF(1), HIF1A(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), RICTOR(1), RPS6KA1(1), RPS6KB2(1), ULK3(1), VEGFA(1) 39206098 320 296 30 10 4 6 5 297 8 0 <1.00e-15 <1.00e-15 <6.84e-14 9 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(5), HRAS(17), PIK3CA(3), PIK3R1(2), PLCG1(1), SHC1(1), SOS1(2) 11466569 31 31 14 1 2 4 14 9 2 0 0.000739 <1.00e-15 <6.84e-14 10 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(2), BRAF(291), CAMP(1), SNX13(1), SRC(2) 8121202 297 291 9 4 3 0 2 289 3 0 <1.00e-15 1.22e-15 7.52e-14 11 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ABI2(1), APC(3), APC2(1), ARHGEF4(1), ARHGEF6(1), ARHGEF7(2), ARPC1B(1), BRAF(291), CDC42(1), CHRM4(1), CHRM5(1), CYFIP1(1), EZR(1), FGD1(2), FGD3(1), FGF20(1), FGF5(1), FGF7(1), FGFR2(1), FN1(3), GSN(1), HRAS(17), IQGAP1(1), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), ITGAD(2), ITGAL(4), ITGAM(2), ITGAV(1), ITGAX(1), ITGB1(2), ITGB2(1), ITGB3(1), ITGB8(1), KRAS(5), MAP2K1(1), MYH10(4), MYH14(1), MYLK(4), NCKAP1L(1), NRAS(40), PAK3(2), PAK7(2), PDGFRB(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PIP4K2C(1), PIP5K1A(1), PPP1R12B(1), SOS1(2), SOS2(2), SSH3(1), TIAM2(4), VAV2(1), VCL(2), WASL(1) 203882723 450 376 106 36 14 25 56 337 18 0 <1.00e-15 1.67e-15 9.33e-14 12 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(291), EEF2K(1), MAP2K1(1), MAP3K8(1), RAP1A(1), RPS6KA1(1), SHC1(1), SOS1(2), SOS2(2) 21770082 302 294 14 5 2 3 2 291 4 0 <1.00e-15 1.89e-15 9.47e-14 13 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(5), BRAF(291), CAMP(1), CREBBP(1), JUN(1), MAP1B(3), MAPK10(1), MAPK8IP2(1), PIK3C2G(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), SHC1(1), SRC(2) 37909515 315 293 25 6 6 6 2 296 5 0 <1.00e-15 2.00e-15 9.47e-14 14 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(1), ACACB(1), AKT1(5), AKT2(1), AKT3(1), BAD(1), BRAF(291), CALML6(1), CBL(1), EXOC7(1), FASN(1), FLOT2(1), GYS2(1), HRAS(17), INPP5D(1), INSR(1), IRS1(3), IRS2(2), KRAS(5), LIPE(1), MAP2K1(1), MAPK10(1), NRAS(40), PCK2(1), PDE3A(1), PFKP(2), PHKA2(3), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PKLR(1), PPARGC1A(3), PPP1R3B(1), PRKAG2(1), PRKAR2A(1), PYGB(1), RAPGEF1(2), RHOQ(2), RPS6KB2(1), SHC1(1), SOS1(2), SOS2(2), SREBF1(1), TRIP10(1) 118308612 420 368 75 30 13 13 54 328 12 0 1.33e-15 2.33e-15 9.57e-14 15 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(5), ABL2(1), AKT1(5), AKT2(1), AKT3(1), BAD(1), BRAF(291), CAMK2A(1), CAMK2B(1), CBL(1), CDKN1A(1), ERBB2(1), ERBB3(3), ERBB4(3), HRAS(17), JUN(1), KRAS(5), MAP2K1(1), MAPK10(1), MYC(1), NCK1(2), NRAS(40), NRG2(1), PAK3(2), PAK7(2), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLCG1(1), RPS6KB2(1), SHC1(1), SOS1(2), SOS2(2), SRC(2), STAT5B(1) 76094436 413 363 65 17 10 12 53 322 15 1 <1.00e-15 2.33e-15 9.57e-14 16 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(5), AKT1(5), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF6(1), ARHGEF7(2), BRAF(291), CDC42(1), CDKN2A(1), FYN(1), GRB7(1), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), MAPK10(1), MAPK8IP2(1), MYLK(4), P4HB(1), PAK3(2), PAK7(2), PIK3CA(3), PIK3CB(1), PKLR(1), PLCG1(1), PTEN(2), SHC1(1), SOS1(2), SOS2(2), SRC(2), TLN1(1), TLN2(3), ZYX(1) 90144192 351 309 58 16 16 11 3 309 11 1 <1.00e-15 3.11e-15 1.20e-13 17 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(291), HRAS(17), JUN(1), MAP2K1(1), MAP2K6(1), MAP3K1(3), MAP3K3(3), MAP3K6(1), MAP3K8(1), MAP3K9(1), MAP4K4(1), MAPK10(1), MAPK4(1), MAPKAPK3(1), MEF2B(1), MYC(1), RPS6KA1(1), RPS6KA4(1), RPS6KB2(1), SHC1(1), SP1(1), STAT1(1), TGFBR1(1), TRADD(1) 70035174 334 318 31 10 6 3 19 298 8 0 <1.00e-15 4.22e-15 1.53e-13 18 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(291), FYN(1), HCST(1), HLA-E(1), HRAS(17), IFNAR2(1), IFNGR1(1), ITGAL(4), ITGB2(1), KIR2DL3(1), KIR3DL1(1), KIR3DL2(1), KRAS(5), LCK(1), MAP2K1(1), NCR1(1), NFAT5(3), NFATC1(1), NFATC4(3), NRAS(40), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLCG1(1), PTK2B(2), SHC1(1), SOS1(2), SOS2(2), SYK(1), ULBP1(1), VAV2(1) 83770111 401 363 58 23 10 10 52 317 12 0 1.22e-15 5.55e-15 1.90e-13 19 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(5), GHR(1), HRAS(17), IGF1R(3), PIK3CA(3), PIK3R1(2), SHC1(1) 9830543 32 31 15 1 3 3 14 9 3 0 0.000764 7.66e-15 2.48e-13 20 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(17), PTK2B(2), SHC1(1), SOS1(2), SRC(2) 6497744 24 23 9 0 2 3 14 5 0 0 0.000373 5.66e-14 1.72e-12 21 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(5), AKT2(1), AKT3(1), CDKN1A(1), HRAS(17), MAP2K1(1), PIK3CA(3), PIK3CD(2), SHC1(1), SOS1(2) 11989474 34 34 17 3 3 5 14 8 4 0 0.00560 5.87e-14 1.72e-12 22 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(5), AKT2(1), AKT3(1), BAD(1), CDC42(1), HRAS(17), KDR(2), KRAS(5), MAP2K1(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC4(3), NRAS(40), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCG1(1), SH2D2A(2), SPHK2(1), SRC(2), VEGFA(1) 53111671 107 100 50 13 9 7 51 33 7 0 6.99e-05 6.22e-14 1.74e-12 23 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(5), AKT2(1), AKT3(1), FYN(1), HRAS(17), INPP5D(1), KRAS(5), LYN(1), MAP2K1(1), MAP2K6(1), MAPK10(1), MS4A2(1), NRAS(40), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCG1(1), SOS1(2), SOS2(2), SYK(1), VAV2(1) 53154671 101 98 44 12 5 7 49 31 9 0 0.000200 1.43e-13 3.83e-12 24 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(17), MMP2(1), RECK(1) 5573695 19 19 4 1 0 0 14 5 0 0 0.0355 1.00e-11 2.58e-10 25 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(5), HRAS(17), MEF2B(1), PIK3CA(3), PIK3R1(2), PLCG1(1), RPS6KA1(1), SHC1(1) 13952446 31 31 14 2 3 3 14 8 3 0 0.00527 3.84e-11 9.47e-10 26 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(5), AKT2(1), AKT3(1), FCGR2B(1), HRAS(17), INPP5D(1), JUN(1), KRAS(5), LILRB3(1), LYN(1), NFAT5(3), NFATC1(1), NFATC4(3), NRAS(40), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), SYK(1), VAV2(1) 54916983 97 96 40 13 6 7 49 28 7 0 0.000214 2.15e-10 5.10e-09 27 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(5), AKT2(1), AKT3(1), CBL(1), CD28(1), CD3D(1), CD4(1), CD40LG(1), CDC42(1), FYN(1), HRAS(17), JUN(1), KRAS(5), LCK(1), MAP3K8(1), NCK1(2), NFAT5(3), NFATC1(1), NFATC4(3), NRAS(40), PAK3(2), PAK7(2), PDCD1(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLCG1(1), RASGRP1(1), SOS1(2), SOS2(2), VAV2(1) 74789235 114 112 57 14 12 11 50 33 8 0 1.85e-05 1.54e-09 3.52e-08 28 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), HRAS(17), JUN(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), PLCG1(1), SHC1(1), SOS1(2) 14157293 29 29 14 3 3 1 14 7 4 0 0.0175 1.88e-08 4.14e-07 29 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(5), CDKN1A(1), HRAS(17), PIK3CA(3), PIK3R1(2), RB1(2) 14882567 30 30 13 3 1 4 14 9 2 0 0.0114 4.87e-08 1.03e-06 30 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(5), BAD(1), CDC42(1), H2AFX(1), HRAS(17), MAP2K1(1), PIK3CA(3), PIK3R1(2) 14140208 31 31 14 4 0 3 14 10 4 0 0.0437 5.44e-08 1.12e-06 31 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 HRAS(17), JUN(1), MAP2K1(1), MAP3K1(3), PLCG1(1), PTK2B(2), SHC1(1), SOS1(2), SRC(2), SYT1(1) 20995527 31 30 16 2 4 4 14 6 3 0 0.00298 1.51e-07 3.01e-06 32 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), CACNA1C(2), CACNA1D(4), CACNA1S(1), CALML6(1), CAMK2A(1), CAMK2B(1), CDC42(1), GNAS(3), HRAS(17), ITPR1(2), ITPR2(6), JUN(1), KRAS(5), MAP2K1(1), MAP2K6(1), MAP3K1(3), MAP3K3(3), MAPK10(1), MMP2(1), NRAS(40), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLD2(1), PTK2B(2), SOS1(2), SOS2(2), SRC(2) 93919280 118 105 63 12 14 10 49 37 8 0 8.77e-06 1.77e-07 3.42e-06 33 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(1), HRAS(17), PML(1), RARA(1), RB1(2), TNFRSF1A(1), TNFRSF1B(1), TP53(4) 13987761 28 27 13 3 2 1 14 5 6 0 0.0226 2.66e-07 4.96e-06 34 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), HRAS(17), IL2RA(1), IL2RG(1), JAK1(1), JUN(1), LCK(1), MAP2K1(1), SHC1(1), SOS1(2), STAT5B(1), SYK(1) 17276664 29 29 14 3 3 3 15 4 4 0 0.0124 4.21e-07 7.62e-06 35 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(5), BAD(1), HRAS(17), IGF1R(3), IRS1(3), MAP2K1(1), PIK3CA(3), PIK3R1(2), SHC1(1), SOS1(2) 13994223 38 36 21 6 2 4 14 13 5 0 0.0726 4.61e-07 8.12e-06 36 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 AKT1(5), CAMK2A(1), CAMK2B(1), GNAS(3), HRAS(17), PIK3CA(3), PIK3R1(2), PRKAR2A(1), RPS6KA1(1), SOS1(2) 21444773 36 35 19 4 2 4 15 11 4 0 0.0231 6.90e-07 1.18e-05 37 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), HRAS(17), JUN(1), MYC(1), PLCG1(1) 15143827 23 22 7 0 3 2 15 3 0 0 0.000508 7.54e-07 1.26e-05 38 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), GNAS(3), GNGT1(1), HRAS(17), MYT1(1), PRKAR2A(1), RPS6KA1(1), SRC(2) 15126686 27 27 12 3 2 0 15 9 1 0 0.0701 1.90e-06 3.08e-05 39 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 HRAS(17), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), RPS6KA1(1), SHC1(1), SOS1(2), SYK(1), VAV2(1) 23702364 29 29 14 1 2 1 15 5 6 0 0.00284 2.14e-06 3.38e-05 40 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(5), CDKN2A(1), MYC(1), PIK3CA(3), PIK3R1(2), POLR1A(1), POLR1B(2), RB1(2), TBX2(1), TP53(4), TWIST1(1) 14969711 23 23 20 1 3 2 1 4 13 0 0.0239 2.32e-06 3.58e-05 41 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), HRAS(17), MAP2K1(1) 6044013 19 19 4 4 0 0 14 3 2 0 0.394 3.05e-06 4.58e-05 42 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 GNGT1(1), HRAS(17), MAP2K1(1), PIK3C2G(1), PIK3CA(3), PIK3R1(2), PLCG1(1), PTK2B(2) 20268163 28 27 13 2 1 3 14 7 3 0 0.00808 3.77e-06 5.53e-05 43 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 ETS1(2), HDAC5(1), HRAS(17), JUN(1), NCOR2(1), RBL1(1), RBL2(1), SIN3B(1) 19110262 25 25 10 1 2 2 14 7 0 0 0.00333 4.61e-06 6.60e-05 44 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(7), ATR(3), CHEK1(1), CHEK2(4), TP53(4) 11753511 19 19 19 1 0 2 3 6 8 0 0.0527 6.23e-06 8.73e-05 45 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 GNGT1(1), HRAS(17), ITGB1(2), MAP2K1(1), PLCB1(1), SRC(2), SYK(1) 17931698 25 25 10 2 1 1 14 7 2 0 0.0177 1.15e-05 0.000157 46 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 HRAS(17), JUN(1), MAP2K1(1), MYC(1), PLCB1(1) 11460452 21 21 6 3 1 0 15 4 1 0 0.0931 1.76e-05 0.000236 47 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(5), HRAS(17), JAK2(1), JUN(1), MAP2K1(1), MAP3K1(3), MYC(1), PIK3CA(3), PIK3R1(2), SOS1(2), STAT1(1), STAT5B(1) 20708568 38 38 21 6 2 4 15 11 6 0 0.0414 2.22e-05 0.000291 48 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 HRAS(17), JUN(1), MAP2K1(1), MAP3K1(3), MEF2B(1), PTK2B(2), SHC1(1), SOS1(2), SRC(2), SYT1(1) 24720281 31 30 16 3 4 4 14 6 3 0 0.00887 2.31e-05 0.000296 49 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(5), ATM(7), BRCA1(1), CDKN1A(1), CHEK1(1), CHEK2(4), JUN(1), RAD51(1), TP53(4), TP73(3) 21947034 28 26 25 2 1 7 4 6 10 0 0.0280 2.79e-05 0.000350 50 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), HRAS(17), JAK1(1), JUN(1), MAP2K1(1), MAP3K1(3), PIK3CA(3), PIK3R1(2), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), STAT1(1) 27713391 36 36 21 4 3 2 15 10 6 0 0.0135 2.89e-05 0.000356 51 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), HRAS(17), MAP2K1(1), PTPRB(2), RASA1(2), SHC1(1), SOS1(2), SRC(2) 18355089 28 26 13 3 2 1 15 6 4 0 0.0275 6.01e-05 0.000726 52 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), FYN(1), HRAS(17), JUN(1), LCK(1), MAP2K1(1), MAP3K1(3), NFATC1(1), NFATC4(3), PIK3CA(3), PIK3R1(2), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), SYT1(1) 35358039 41 41 26 4 6 3 16 10 6 0 0.00385 7.67e-05 0.000908 53 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(4), ATM(7), CDKN1A(1), RB1(2), TP53(4) 13321231 18 18 18 0 1 4 3 4 6 0 0.00951 8.01e-05 0.000931 54 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 FYN(1), GSN(1), HRAS(17), ITGB1(2), MAP2K1(1), MYLK(4), PIK3CA(3), PIK3R1(2), SHC1(1), SRC(2), TLN1(1) 27481313 35 33 20 4 6 1 14 8 6 0 0.0156 0.000115 0.00132 55 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 HRAS(17), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), NFATC1(1), NFATC4(3), PIK3CA(3), PIK3R1(2), PLCG1(1), SHC1(1), SOS1(2), SYK(1), SYT1(1) 31834326 38 38 23 4 5 3 15 9 6 0 0.00562 0.000134 0.00150 56 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(5), AKT2(1), AKT3(1), PIK3CA(3), PIK3CD(2), PTEN(2), PTK2B(2), RBL2(1), SHC1(1), SOS1(2) 15040750 20 20 18 2 3 7 0 6 3 1 0.0459 0.000148 0.00163 57 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), HRAS(17), IGF1R(3), IRS1(3), JUN(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), RASA1(2), SHC1(1), SOS1(2) 18370968 36 34 21 6 3 1 15 12 5 0 0.0816 0.000217 0.00235 58 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(5), MAP2K1(1), MAP2K6(1), MAP3K1(3), PIK3CA(3), PIK3R1(2), RB1(2), SP1(1) 14305335 18 18 16 1 1 4 1 7 5 0 0.0575 0.000257 0.00273 59 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 GNAS(3), GNGT1(1), HRAS(17), MAP2K1(1), PIK3C2G(1), PLCB1(1), PPP1R12B(1) 18409872 25 25 10 3 1 2 14 7 1 0 0.0510 0.000271 0.00283 60 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(5), AKT2(1), AKT3(1), BAD(1), CDKN2A(1), IARS(3), IGFBP1(1), INPP5D(1), PIK3CA(3), PPP1R13B(1), PTEN(2), RPS6KA1(1), SHC1(1), SOS1(2), SOS2(2), YWHAE(1), YWHAG(1) 26591031 28 28 26 2 2 8 1 9 7 1 0.0156 0.000283 0.00291 61 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 FPR1(1), GNGT1(1), HRAS(17), MAP2K1(1), MAP2K6(1), MAP3K1(3), NFATC1(1), NFATC4(3), PIK3C2G(1), PLCB1(1), SYT1(1) 28206723 31 31 16 3 2 3 14 9 3 0 0.0116 0.000306 0.00309 62 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 GNAS(3), GNGT1(1), HRAS(17), IGF1R(3), ITGB1(2), MAP2K1(1), MYC(1), PTPRR(2), RPS6KA1(1), SHC1(1), SOS1(2), SRC(2) 24440978 36 36 21 5 5 3 15 10 3 0 0.0419 0.000330 0.00327 63 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 HRAS(17), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), NFATC1(1), NFATC4(3), PLCG1(1), SHC1(1), SOS1(2), SYK(1), SYT1(1) 28295735 33 33 18 4 5 3 15 6 4 0 0.0119 0.000390 0.00382 64 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(7), ATR(3), BRCA1(1), BRCA2(3), CHEK1(1), CHEK2(4), FANCC(1), FANCD2(3), FANCF(1), FANCG(2), RAD17(2), RAD51(1), TP53(4), TREX1(1) 32415292 34 32 33 3 0 6 7 10 11 0 0.0182 0.000424 0.00408 65 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 AKT1(5), ATM(7), CDKN1A(1), FHL2(1), HIF1A(1), TP53(4) 15314505 19 18 17 1 0 5 3 6 5 0 0.0317 0.000445 0.00422 66 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), HRAS(17), MAP2K6(1), MAP3K1(3), MAP3K9(1), MEF2B(1), MYC(1), SHC1(1), STAT1(1), TGFBR1(1), TRADD(1) 27054992 29 29 14 3 2 0 16 8 3 0 0.0261 0.000662 0.00618 67 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(3), HRAS(17), JAK2(1), MAP2K1(1), SHC1(1), SOS1(2), STAT5B(1) 13019436 26 26 11 5 2 2 14 5 3 0 0.144 0.000760 0.00699 68 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), HRAS(17), JAK1(1), JUN(1), MAP2K1(1), MAP3K1(3), PIK3CA(3), PIK3R1(2), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), STAT1(1) 25829435 36 36 21 5 3 2 15 10 6 0 0.0291 0.000898 0.00814 69 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), HRAS(17), INSR(1), IRS1(3), JUN(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), RASA1(2), SHC1(1), SOS1(2) 18883770 34 33 19 6 2 1 15 11 5 0 0.0891 0.00108 0.00963 70 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(7), CHEK1(1), MYT1(1), RB1(2), TP53(4), WEE1(1) 12935159 16 15 16 1 1 3 2 4 6 0 0.0948 0.00114 0.0100 71 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), HRAS(17), JAK1(1), JAK2(1), JUN(1), MAP2K1(1), SHC1(1), SOS1(2) 17650345 25 25 10 4 3 2 14 4 2 0 0.0579 0.00125 0.0108 72 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), HRAS(17), JAK2(1), JUN(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), STAT1(1), STAT5B(1), THPO(2) 22088924 36 36 21 6 4 1 15 11 5 0 0.0698 0.00132 0.0113 73 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B4(1), EIF2S2(1), FLT4(1), HIF1A(1), HRAS(17), KDR(2), PIK3CA(3), PIK3R1(2), PLCG1(1), SHC1(1) 25018382 30 30 15 4 3 1 16 8 2 0 0.0297 0.00142 0.0119 74 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 GNAS(3), GNGT1(1), HRAS(17), JUN(1), MAP2K1(1), NFATC1(1), NFATC4(3), PLCG1(1), PRKAR2A(1), SYT1(1) 25842827 30 30 15 4 5 2 15 7 1 0 0.0290 0.00150 0.0125 75 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(5), ITGB1(2), PIK3CA(3), PIK3R1(2), PTEN(2), SHC1(1), SOS1(2) 14200971 17 16 15 1 1 5 0 8 2 1 0.0519 0.00161 0.0132 76 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(2), SULT1E1(1), SULT2A1(1), SUOX(3) 4511431 7 7 7 0 1 1 0 1 4 0 0.176 0.00167 0.0136 77 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), HRAS(17), ITGB1(2), JUN(1), MAP2K1(1), MET(2), PIK3CA(3), PIK3R1(2), PTEN(2), PTK2B(2), RAP1A(1), RASA1(2), SOS1(2), SRC(2) 32562202 40 36 25 5 2 5 16 13 3 1 0.0125 0.00181 0.0145 78 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(5), PIK3CA(3), PIK3R1(2), PLCB1(1), PLCG1(1) 9454026 12 12 10 1 1 3 0 6 2 0 0.149 0.00261 0.0206 79 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(5), BAD(1), CBL(1), HRAS(17), IL2RA(1), IL2RG(1), IRS1(3), JAK1(1), MYC(1), PIK3CA(3), PIK3R1(2), SHC1(1), SOS1(2), STAT5B(1), SYK(1) 26642492 41 39 24 7 2 6 15 12 6 0 0.0537 0.00322 0.0251 80 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(5), BAD(1), MUSK(1), PIK3CA(3), PIK3R1(2), PTK2B(2), SRC(2), TERT(2) 12021428 18 16 16 2 3 5 0 7 3 0 0.0708 0.00349 0.0269 81 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPNS2(1), HRAS(17), ITGB1(2), MYLK(4), PRKAR2A(1), TLN1(1) 24135664 27 27 12 4 4 1 16 5 1 0 0.0470 0.00373 0.0284 82 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(1), ACTG1(1), AKT1(5), AKT2(1), AKT3(1), AMOTL1(1), ASH1L(4), CDC42(1), CGN(3), CLDN14(1), CLDN6(1), CSNK2A1(1), CTNNA3(1), CTNNB1(2), EPB41L1(1), EPB41L3(1), HCLS1(1), HRAS(17), INADL(1), JAM2(1), KRAS(5), LLGL1(1), MAGI1(1), MAGI2(1), MAGI3(1), MLLT4(1), MPDZ(2), MYH1(3), MYH10(4), MYH13(3), MYH14(1), MYH15(1), MYH2(2), MYH3(2), MYH4(1), MYH6(3), MYH7(3), MYH7B(2), MYH8(1), NRAS(40), OCLN(1), PARD3(1), PARD6B(1), PPM1J(2), PPP2R1A(3), PPP2R1B(1), PPP2R2B(1), PTEN(2), SPTAN1(1), SRC(2), TJP1(2), TJP3(1), VAPA(1), YES1(1) 143037920 144 132 84 19 13 23 53 39 15 1 4.16e-06 0.00626 0.0470 83 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(5), IGF1R(3), MYC(1), POLR2A(1), RB1(2), TEP1(3), TERT(2), TNKS(1), TP53(4), XRCC5(2) 20785610 24 23 22 3 5 6 2 5 6 0 0.0466 0.00894 0.0658 84 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(2), TAT(1) 1942591 4 4 4 0 1 0 0 2 1 0 0.493 0.00897 0.0658 85 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MYC(1), SP1(1), TP53(4), WT1(1) 5218338 7 7 7 0 0 0 2 2 3 0 0.137 0.0109 0.0787 86 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(5), AKT2(1), AKT3(1), IARS(3), IL2RG(1), INPP5D(1), JAK1(1), JAK2(1), PIK3CA(3), PPP1R13B(1), SHC1(1), SOS1(2), SOS2(2), SRC(2), STAT6(1), TYK2(1) 27211969 27 26 25 3 4 9 1 10 3 0 0.0214 0.0111 0.0793 87 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), AKAP11(2), AKAP12(2), AKAP2(2), AKAP8(2), AKAP9(2), GNAL(2), GNB3(1), GNG5(1), GNGT1(1), HRAS(17), ITPR1(2), KRAS(5), NRAS(40), PALM2(1), PDE1A(1), PDE4B(1), PDE4D(1), PDE7B(1), PLCB3(1), PRKAR2A(1), PRKD1(3), PRKD3(1), USP5(1) 86186798 97 86 42 14 8 3 54 26 6 0 0.000646 0.0115 0.0816 88 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 AKT1(5), BAD(1), CSF2RB(3), IGF1R(3), KIT(4), PIK3CA(3), PIK3R1(2), PRKAR2A(1) 16173302 22 19 20 3 2 4 1 10 5 0 0.145 0.0124 0.0867 89 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(1), ALOX12B(2), ALOX5(1), CBR1(1), CBR3(2), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2U1(1), CYP4A11(2), DHRS4(1), EPHX2(1), GGT1(2), GPX2(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PTGES(1), PTGES2(1) 28697880 27 25 26 2 5 5 3 10 4 0 0.00835 0.0130 0.0897 90 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(7), CHEK1(1), MYT1(1), WEE1(1) 10129121 10 10 10 1 0 2 2 3 3 0 0.343 0.0131 0.0899 91 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), HRAS(17), JAK2(1), JUN(1), MAP2K1(1), PLCG1(1), SHC1(1), SOS1(2), STAT5B(1) 15906351 26 26 11 5 4 1 14 4 3 0 0.117 0.0149 0.101 92 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADRB1(1), GJA1(1), GJD2(1), GNAS(3), GRM1(3), GUCY1A3(1), HRAS(17), HTR2B(1), ITPR1(2), ITPR2(6), KRAS(5), MAP2K1(1), NPR1(2), NRAS(40), PDGFRB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PRKG1(1), SOS1(2), SOS2(2), SRC(2), TJP1(2), TUBA3C(1), TUBB2B(1) 97389424 106 100 51 16 14 5 49 34 4 0 0.000753 0.0157 0.105 93 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(1), GOT2(2), TAT(1) 3473607 5 5 5 1 2 0 0 2 1 0 0.703 0.0179 0.118 94 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGEF2(4), GBF1(5), GPLD1(1) 11957541 11 11 11 1 1 3 0 2 5 0 0.111 0.0179 0.118 95 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(5), ATM(7), ATR(3), CDKN1A(1), CDKN2A(1), RB1(2), TP53(4) 22283236 23 23 20 3 1 3 2 5 12 0 0.199 0.0220 0.143 96 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(5), BAD(1), GHR(1), PIK3CA(3), PIK3R1(2) 10379578 12 12 10 2 1 3 0 5 3 0 0.363 0.0272 0.175 97 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(1), DNMT1(2), DNMT3A(5), MARS(1), MARS2(1), MAT1A(1), MTR(1), TAT(1) 15298627 13 13 13 0 4 1 0 2 6 0 0.0269 0.0314 0.200 98 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), CS(1), ME1(1), PC(3) 6837957 7 7 7 1 2 3 1 1 0 0 0.207 0.0318 0.200 99 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(1) 1493047 2 2 2 0 1 0 1 0 0 0 0.549 0.0329 0.205 100 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(1), HLA-DRA(1), LCK(1), PIK3CA(3), PIK3R1(2) 9437544 9 9 9 0 2 0 2 3 2 0 0.0975 0.0353 0.217 101 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(2), CNR2(2), DNMT1(2), MTNR1B(1), PTGER4(1) 8237855 9 9 9 1 4 0 0 4 1 0 0.232 0.0380 0.232 102 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 DNMT1(2), DNMT3A(5), MARS(1), MARS2(1), MAT1A(1), MTR(1) 12823101 11 11 11 0 4 1 0 1 5 0 0.0315 0.0385 0.232 103 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(1), HLA-DRA(1) 1746622 3 3 3 0 2 0 1 0 0 0 0.359 0.0405 0.242 104 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1), CD3D(1), CD4(1) 2367971 3 3 3 0 2 0 1 0 0 0 0.348 0.0411 0.243 105 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(5), ANGPTL2(1), DGKA(1), ITGA9(1), ITPR1(2), ITPR2(6), MAP2K1(1), PDE3A(1), PIK3C2G(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), RPS4X(1) 35803142 27 27 25 2 5 5 1 10 6 0 0.0121 0.0450 0.264 106 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(1), FYN(1), IL2RG(1), IL7R(3), JAK1(1), LCK(1), PIK3CA(3), PIK3R1(2), PTK2B(2), STAT5B(1) 20638010 16 16 16 1 0 4 2 4 6 0 0.0592 0.0455 0.264 107 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(5), APAF1(4), ATM(7), BAD(1), CASP6(1), STAT1(1), TLN1(1), TP53(4) 20182417 24 23 22 4 1 6 3 7 7 0 0.221 0.0477 0.275 108 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 GGT1(2), LCMT1(2), MARS(1), MARS2(1), MAT1A(1), METTL2B(1), PAPSS1(2), PRMT3(1), PRMT8(3) 18389027 14 14 13 1 4 2 2 4 2 0 0.0480 0.0518 0.293 109 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(5), APC(3), CAMP(1), ITPR1(2), ITPR2(6), KCNJ9(1), PITX2(2), RYR1(8) 33788580 29 28 26 3 7 7 0 12 3 0 0.00777 0.0519 0.293 110 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(7), ATR(3), BRCA1(1), CDKN1A(1), CHEK1(1), CHEK2(4), MYT1(1), PRKDC(5), RPS6KA1(1), TP53(4), WEE1(1) 30552636 29 26 29 3 0 4 4 9 12 0 0.0776 0.0560 0.313 111 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH4(1), ADH7(2) 4156497 4 4 4 1 1 0 0 3 0 0 0.641 0.0618 0.343 112 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), KERA(1) 2681829 3 3 3 0 2 0 0 0 1 0 0.399 0.0684 0.376 113 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(1), ALOX5(1), CBR1(1), CBR3(2), EPX(1), GGT1(2), MPO(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PRDX1(1), PRDX6(1), PTGES2(1), TPO(1) 20556232 19 18 19 2 3 1 2 9 4 0 0.124 0.0703 0.383 114 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(1), GOT2(2), LDHA(2) 5052282 5 5 5 1 1 0 1 3 0 0 0.552 0.0739 0.399 115 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 ITGB1(2), MAP2K1(1), PIK3CA(3), PIK3R1(2), PTK2B(2), SYK(1) 13712747 11 11 11 0 0 3 0 4 4 0 0.0541 0.0747 0.400 116 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 840008 1 1 1 0 1 0 0 0 0 0 0.717 0.0799 0.425 117 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), CAPNS2(1), FYN(1), HRAS(17), ITGB1(2), JUN(1), MAP2K1(1), PPP1R12B(1), RAP1A(1), SHC1(1), SOS1(2), SRC(2), TLN1(1), VCL(2), ZYX(1) 34654492 35 34 20 6 4 4 16 8 3 0 0.0769 0.0839 0.442 118 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(1), HRAS(17), INSR(1), IRS1(3), JAK2(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), PLCG1(1), RPS6KA1(1), SHC1(1), SOS1(2), STAT5B(1) 24391447 35 34 20 8 4 1 14 10 6 0 0.248 0.0899 0.469 119 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(1), CD38(2), ENPP1(2), NADSYN1(1), NNT(1), NT5E(1), QPRT(1) 10726268 9 8 9 1 3 2 2 1 1 0 0.164 0.0937 0.485 120 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(1), CD38(2), ENPP1(2), NADK(1), NADSYN1(1), NNT(1), NT5C1B(1), NT5E(1), NUDT12(1), QPRT(1) 15864773 12 11 12 1 4 2 3 2 1 0 0.0801 0.101 0.518 121 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDKN1A(1), CDKN2A(1), TP53(4) 6265903 6 6 6 0 0 0 0 2 4 0 0.182 0.102 0.518 122 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 GGT1(2), MARS(1), MARS2(1), MAT1A(1), PAPSS1(2) 9123170 7 7 7 0 3 0 0 3 1 0 0.167 0.103 0.518 123 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 LCMT1(2), METTL2B(1), PCYT1A(1), PRMT3(1), PRMT8(3) 10402099 8 8 7 1 1 2 2 1 2 0 0.211 0.107 0.529 124 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(5), GNAS(3), GNGT1(1), PIK3CA(3), PIK3R1(2), SYT1(1) 13168390 15 15 13 3 1 4 0 8 2 0 0.394 0.108 0.529 125 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(1), CPOX(1), FECH(1), PPOX(1) 5660836 5 5 5 1 0 2 0 3 0 0 0.471 0.108 0.529 126 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), CALML6(1), CAMK2A(1), CAMK2B(1), CREB3L3(3), CREBBP(1), CTNNB1(2), DCT(1), DVL2(2), DVL3(1), FZD10(1), FZD3(1), FZD8(2), GNAS(3), HRAS(17), KIT(4), KRAS(5), LEF1(1), MAP2K1(1), MITF(1), NRAS(40), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), TCF7L1(4), TCF7L2(1), TYRP1(1), WNT11(1), WNT4(1), WNT5B(1) 80369718 108 95 53 21 15 3 51 32 7 0 0.0240 0.108 0.529 127 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(1), HLA-DRA(1) 2923731 3 3 3 0 2 0 1 0 0 0 0.360 0.121 0.589 128 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(4), BAD(1), CES1(1) 7955601 6 6 6 0 0 2 1 1 2 0 0.250 0.131 0.631 129 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 AOC3(1), DDC(1), EPX(1), GOT1(1), GOT2(2), HPD(1), MPO(1), PRDX1(1), PRDX6(1), TAT(1), TPO(1) 16232990 12 11 12 1 3 2 2 3 2 0 0.148 0.134 0.641 130 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 PAPSS1(2), SULT1E1(1), SULT2A1(1), SUOX(3) 6783466 7 7 7 2 1 1 0 1 4 0 0.633 0.136 0.642 131 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), GRIA2(2) 2744070 3 3 3 1 0 0 0 2 1 0 0.862 0.140 0.658 132 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(2), ATP6V0C(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), MTR(1) 13185808 9 9 9 1 0 1 2 3 3 0 0.318 0.156 0.730 133 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(3), GNGT1(1), PRKAR2A(1) 7049568 6 6 6 0 2 0 1 3 0 0 0.229 0.159 0.739 134 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), CKM(2), GPT(1), LDHA(2), NCL(1) 6589030 8 7 8 2 2 3 2 1 0 0 0.334 0.168 0.771 135 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 SDHA(1), SDHD(1), UQCRC1(2) 4882406 4 4 4 1 0 1 1 2 0 0 0.662 0.174 0.793 136 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT1(5), AKT2(1), AKT3(1), ITPR1(2), ITPR2(6), PHKA2(3), PIK3CB(1), PITX2(2), PLD2(1), VN1R1(2) 33036037 24 23 22 3 6 7 0 8 3 0 0.0254 0.181 0.819 137 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(1), CYP1A2(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), HSD3B7(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), RDH14(1) 17621949 12 11 12 1 3 1 2 6 0 0 0.120 0.183 0.825 138 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(2), XDH(1) 5888246 4 4 4 1 0 0 1 3 0 0 0.670 0.192 0.858 139 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB27A(2) 3099067 3 3 3 1 1 0 0 1 1 0 0.727 0.196 0.861 140 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GNT5(1), FUT1(1), FUT3(2) 5313460 4 4 4 0 0 0 2 0 2 0 0.268 0.197 0.861 141 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(2) 3043027 3 3 3 1 1 0 0 2 0 0 0.731 0.198 0.861 142 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), GOT1(1), GOT2(2), TAT(1) 6420769 5 5 5 0 1 1 0 2 1 0 0.300 0.198 0.861 143 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(1), HLA-DRA(1), LCK(1) 6622369 5 5 5 0 3 0 1 0 1 0 0.224 0.202 0.868 144 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AKT1(5), CREBBP(1), HRAS(17), MAP2K1(1), MYH2(2), NFATC1(1), NFATC4(3), PIK3CA(3), PIK3R1(2), PRKAR2A(1), SYT1(1) 37468579 38 38 21 8 2 5 15 12 4 0 0.144 0.204 0.873 145 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(1), MPO(1), MTHFR(2), PRDX6(1), TPO(1) 8558328 6 6 6 1 1 1 0 2 2 0 0.584 0.206 0.874 146 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(5), EIF2S2(1), IGF1R(3), PIK3CA(3), PIK3R1(2), PTEN(2) 14478643 16 14 14 3 1 3 0 8 3 1 0.352 0.208 0.879 147 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(2), FBXW7(1), RB1(2) 6054181 5 4 5 0 1 1 0 1 2 0 0.204 0.214 0.895 148 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(5), APC(3), AXIN1(1), CTNNB1(2), GJA1(1), LBP(1), LEF1(1), PIK3CA(3), PIK3R1(2), TLR4(1) 22735579 20 20 18 4 1 5 2 8 4 0 0.252 0.215 0.895 149 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP68(1), SRP72(1), SRPR(2) 5561101 4 4 4 1 0 2 0 1 1 0 0.668 0.219 0.899 150 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1B(1), CDC42(1), PIK3CA(3), PIK3R1(2), WASL(1) 9866583 8 7 8 1 0 1 0 5 2 0 0.437 0.220 0.899 151 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), CPOX(1), EPRS(2), FECH(1), HCCS(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A3(2), UGT1A4(1) 20189398 12 12 12 1 1 1 3 6 1 0 0.162 0.220 0.899 152 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA2(2), GABRA3(1), GABRA6(1), SRC(2) 8792131 6 6 6 1 1 1 1 2 1 0 0.464 0.231 0.937 153 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1), HSD3B7(1), RDH14(1) 3539654 3 3 3 0 1 0 0 2 0 0 0.460 0.235 0.946 154 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA2(2), GABRA3(1), GABRA6(1) 5798483 4 4 4 0 0 1 1 1 1 0 0.376 0.237 0.948 155 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(2), GGT1(2), GPX2(1), GSTA2(1), GSTM3(1), GSTO2(2) 13318599 9 9 9 1 2 3 2 1 1 0 0.186 0.239 0.950 156 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), MPO(1), PRDX6(1), TPO(1) 6158606 4 4 4 0 1 1 0 1 1 0 0.335 0.243 0.955 157 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDKN1A(1), CHEK1(1), WEE1(1) 5029107 3 3 3 0 0 1 0 1 1 0 0.578 0.243 0.955 158 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 GNAS(3), GNGT1(1) 4847285 4 4 4 1 1 0 0 3 0 0 0.731 0.253 0.986 159 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 GOT1(1), GOT2(2), TAT(1) 6131167 4 4 4 0 1 0 0 2 1 0 0.486 0.254 0.986 160 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 FHL5(1), FSHR(1), GNAS(3) 7026784 5 5 5 1 1 1 0 3 0 0 0.603 0.260 1.000 161 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 LCMT1(2), METTL2B(1), PRMT3(1), PRMT8(3) 11083682 7 7 6 1 1 2 2 1 1 0 0.204 0.263 1.000 162 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(2), SP1(1) 4900478 3 3 3 0 1 1 1 0 0 0 0.333 0.269 1.000 163 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), CS(1), FH(1), IDH3B(1), OGDH(1), OGDHL(2), PC(3), PCK2(1), SDHA(1), SDHD(1) 22047713 14 13 14 0 3 4 2 5 0 0 0.00905 0.274 1.000 164 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(1), ANPEP(2), CMA1(1), ENPEP(3), LNPEP(2) 15594550 9 9 9 1 2 3 3 1 0 0 0.112 0.275 1.000 165 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT3(2) 3746845 3 3 3 0 0 0 2 0 1 0 0.543 0.276 1.000 166 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F7(1), FGA(1), PROC(1), PROS1(2) 12071186 7 7 7 1 3 0 1 3 0 0 0.349 0.282 1.000 167 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(1), CPT1A(3), LEPR(1), PRKAG2(1) 10666232 6 6 6 1 2 1 1 1 1 0 0.331 0.293 1.000 168 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(1), CPS1(1), GOT1(1) 5742596 3 3 3 1 2 0 0 0 0 1 0.657 0.295 1.000 169 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(3), NRG2(1) 6640624 4 4 4 0 0 0 0 3 1 0 0.384 0.299 1.000 170 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(2), MTHFD1(2), MTHFD1L(1), MTHFR(2), MTR(1) 13952447 8 8 8 1 0 1 2 2 3 0 0.365 0.302 1.000 171 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX5(1), GGT1(2), PLA2G2A(1), PLA2G6(1), PTGES(1) 11089549 7 7 7 1 2 1 1 2 1 0 0.286 0.313 1.000 172 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(1), PSAT1(1) 3576251 2 2 2 1 0 0 1 1 0 0 0.893 0.314 1.000 173 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(1), ADCY9(3), ATP6V0C(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ERO1L(1), GNAS(3), PLCG1(1), TRIM23(1) 27192948 17 16 17 2 2 1 2 10 2 0 0.227 0.316 1.000 174 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(1), PTK2B(2) 4964549 3 3 3 1 1 2 0 0 0 0 0.516 0.321 1.000 175 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD2(1), GGT1(2) 4228482 3 3 3 0 1 1 0 1 0 0 0.337 0.321 1.000 176 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(3), CDK5(1), CHN1(1), MAP3K1(3), MYLK(4), PIK3CA(3), PIK3R1(2), PPP1R12B(1), TRIO(3) 25714819 21 21 21 4 5 3 2 5 6 0 0.178 0.325 1.000 177 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GGT1(2) 4019907 3 3 3 1 1 0 1 1 0 0 0.702 0.327 1.000 178 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN2A(2), GRIN2B(4), GRIN2D(3), NOS1(1), PRKAR2A(1), SYT1(1) 18841445 12 12 12 0 2 5 1 3 1 0 0.0134 0.329 1.000 179 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(1), IL2RA(1), TGFBR1(1), TGFBR2(1), TGFBR3(1) 7800552 6 6 6 2 2 1 3 0 0 0 0.577 0.329 1.000 180 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 JUN(1), KEAP1(2), MAFK(1) 6523615 4 4 4 0 1 1 1 0 1 0 0.288 0.329 1.000 181 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2) 2820667 2 2 2 1 0 2 0 0 0 0 0.736 0.341 1.000 182 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), JAK1(1), STAT1(1), STAT2(1), TYK2(1) 8002296 5 5 5 0 0 2 0 3 0 0 0.215 0.341 1.000 183 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(5), AVP(1), CABIN1(1), HDAC5(1), IGF1R(3), INSR(1), MAP2K6(1), MEF2B(1), NFATC1(1), PIK3CA(3), PIK3R1(2), SYT1(1) 25641133 21 20 19 4 4 5 0 8 4 0 0.163 0.348 1.000 184 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(5), BAD(1), EEA1(1), LYN(1), PFKP(2), PLCG1(1), VAV2(1) 18421026 12 12 10 2 2 4 2 2 2 0 0.217 0.350 1.000 185 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD3D(1), CD4(1), CREBBP(1), GNAS(3), GNGT1(1), HLA-DRA(1), LCK(1), PRKAR2A(1) 16869262 10 10 10 1 4 0 2 3 1 0 0.192 0.357 1.000 186 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD3D(1), CD4(1), CREBBP(1), GNAS(3), GNGT1(1), HLA-DRA(1), LCK(1), PRKAR2A(1) 16869262 10 10 10 1 4 0 2 3 1 0 0.192 0.357 1.000 187 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 AFMID(1), CS(1), MTHFD1(2), MTHFD1L(1) 9881229 5 5 5 0 0 2 2 0 1 0 0.161 0.361 1.000 188 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB11(4), ABCB4(1), ABCC3(1) 10522726 6 6 6 0 1 0 2 2 1 0 0.145 0.362 1.000 189 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 1123657 1 1 1 0 0 0 0 1 0 0 0.848 0.368 1.000 190 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GFPT1(1), HEXA(1), HEXB(1), HK2(3), HK3(1), RENBP(1) 12506808 8 7 8 1 1 2 1 2 2 0 0.200 0.371 1.000 191 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(1), FPGT(1), GMDS(1), HK2(3), HK3(1), PFKFB3(1), PFKFB4(1), PFKP(2), PMM2(1) 17661676 12 12 12 2 2 3 3 1 3 0 0.159 0.372 1.000 192 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC2(2), BCHE(2), CES1(1), UGT1A1(1), UGT1A3(2), UGT1A4(1) 16859167 9 9 9 0 0 1 3 5 0 0 0.0887 0.373 1.000 193 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 HADHA(1), SDS(1) 3574081 2 2 2 1 1 0 0 1 0 0 0.870 0.374 1.000 194 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACSS1(1), ACSS2(1), FH(1) 9803965 5 5 5 0 1 1 0 2 1 0 0.179 0.381 1.000 195 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(4), ATM(7), ATR(3), BAI1(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(4), PPM1D(6), PTEN(2), SESN3(1), STEAP3(1), THBS1(1), TP53(4), TP73(3) 48180599 40 37 40 7 2 9 5 8 15 1 0.100 0.386 1.000 196 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(4), JUN(1) 9505475 5 5 5 1 1 2 1 0 1 0 0.456 0.389 1.000 197 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ARPC1B(1), CDC42(1), WASL(1) 5976804 4 4 4 1 0 1 0 3 0 0 0.670 0.391 1.000 198 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC3(1), CES1(1) 4456113 2 2 2 0 0 0 1 1 0 0 0.606 0.393 1.000 199 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), CD4(1), ITGAL(4), ITGB2(1) 8287592 8 8 8 3 3 2 2 0 1 0 0.503 0.393 1.000 200 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 MAP2K1(1), MAP3K1(3), NCOR2(1), RARA(1), THRA(1) 12709523 7 7 7 1 1 0 0 2 4 0 0.583 0.395 1.000 201 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 MBTPS1(2), SCAP(1), SREBF1(1), SREBF2(1) 8813345 5 5 5 0 1 1 0 2 1 0 0.221 0.396 1.000 202 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(1), SPR(1) 4820892 3 3 3 1 0 2 0 1 0 0 0.542 0.397 1.000 203 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 CAMK2A(1), CAMK2B(1), CDK5(1), FYN(1), GNGT1(1), HRAS(17), JAK2(1), MAP2K1(1), MYLK(4), PLCG1(1), PTK2B(2), SHC1(1), SOS1(2), STAT1(1), SYT1(1) 30636304 36 35 21 9 7 4 14 6 5 0 0.210 0.400 1.000 204 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(5), CDC42(1), IL1R1(2), JUN(1), MAP3K1(3), MAP3K3(3), MAP3K9(1), MAPK10(1), SHC1(1), TP53(4) 37131023 22 21 20 2 2 7 0 8 5 0 0.0387 0.401 1.000 205 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(1), JUN(1), THBS1(1) 5465209 3 3 3 1 1 1 0 0 1 0 0.700 0.406 1.000 206 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 LTB4R(2) 4407081 2 2 2 1 0 0 1 0 1 0 0.931 0.419 1.000 207 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), GRM1(3), PLCB1(1), PRKAR2A(1) 11782476 6 6 6 1 1 0 2 2 1 0 0.513 0.422 1.000 208 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(1), FH(1), OGDH(1), SDHA(1) 6934007 4 4 4 0 1 1 0 2 0 0 0.284 0.423 1.000 209 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), MET(2), SH3GLB2(1), SH3KBP1(1), SRC(2) 14310947 7 7 7 1 2 0 2 2 1 0 0.367 0.425 1.000 210 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(1), FECH(1) 5902797 3 3 3 1 0 2 0 1 0 0 0.597 0.427 1.000 211 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 JUN(1), PLCG1(1), PTK2B(2), SYT1(1) 10171065 5 5 5 0 2 3 0 0 0 0 0.0904 0.428 1.000 212 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 IFRD1(1), IL1R1(2), NR4A3(1) 7877316 4 4 4 0 0 3 0 0 1 0 0.254 0.428 1.000 213 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA4(1), PSMA6(1), PSMB7(1), PSMD14(1), RPN1(1) 9467624 5 5 5 1 1 1 0 2 1 0 0.602 0.433 1.000 214 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(1), DLAT(1), FH(1), IDH3B(1), OGDH(1), PC(3), PDHA2(1), PDHX(1), PDK3(2), SDHA(1), SDHD(1) 20955023 14 13 14 2 5 4 1 3 1 0 0.122 0.433 1.000 215 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CUL1(2), RB1(2) 6272937 4 3 4 0 1 1 0 1 1 0 0.224 0.435 1.000 216 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2) 3596413 2 2 2 1 0 2 0 0 0 0 0.743 0.445 1.000 217 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CUL1(2), RB1(2) 6302039 4 3 4 0 1 1 0 1 1 0 0.223 0.449 1.000 218 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD4(1) 4544233 2 2 2 0 2 0 0 0 0 0 0.426 0.449 1.000 219 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 DARS(1), EPRS(2), GARS(1), IARS(3), KARS(1), LARS(1), MARS(1), MARS2(1), TARS(1), WARS(1) 23630817 13 13 13 2 2 1 3 5 2 0 0.272 0.462 1.000 220 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CDKN1A(1), CDKN2A(1), CDKN2C(1), RB1(2), RBL1(1) 11865627 6 6 6 0 1 3 0 1 1 0 0.104 0.468 1.000 221 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(1), PTPRU(1), STAT1(1), STAT2(1), TYK2(1) 9233365 5 5 5 0 0 2 0 2 1 0 0.198 0.468 1.000 222 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(1) 1644950 1 1 1 0 0 0 0 1 0 0 0.836 0.474 1.000 223 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CDKN1A(1), NFATC1(1), NFATC4(3), PLCG1(1), SP1(1), SYT1(1) 15480236 8 8 8 1 3 2 1 2 0 0 0.189 0.476 1.000 224 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 AOC3(1), DDC(1), EPX(1), ESCO2(2), GOT1(1), GOT2(2), HPD(1), MPO(1), PRDX6(1), TAT(1), TPO(1) 25250378 13 12 13 0 3 2 2 3 3 0 0.0354 0.479 1.000 225 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 ETS1(2), HRAS(17), JUN(1), MAP2K1(1), MAP2K6(1), MAP3K1(3), SP1(1), TNFRSF1A(1), TNFRSF1B(1) 36201891 28 28 13 5 3 0 15 7 3 0 0.121 0.481 1.000 226 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CD4(1), HLA-DRA(1) 3936264 2 2 2 0 2 0 0 0 0 0 0.441 0.486 1.000 227 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ARPC1B(1), NCK1(2), PIR(1), WASL(1) 11215707 6 6 6 1 1 2 1 2 0 0 0.367 0.489 1.000 228 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ATP6V0C(1), EPX(1), MPO(1), PRDX1(1), PRDX6(1), TPO(1) 8698494 6 6 6 2 1 1 1 2 1 0 0.738 0.489 1.000 229 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(5), IL2RG(1), IRS1(3), JAK1(1), SHC1(1), STAT6(1) 10919487 12 12 10 4 1 5 0 6 0 0 0.532 0.500 1.000 230 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADH(1), HADHA(1), PPT2(1) 6277559 3 3 3 1 1 0 0 2 0 0 0.802 0.505 1.000 231 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1B(1), ADH4(1), ADH7(2), AOC3(1), AOX1(1), DCT(1), DDC(1), GOT1(1), GOT2(2), HGD(1), HPD(1), TAT(1), TPO(1) 23409626 15 14 15 3 4 2 2 6 1 0 0.327 0.506 1.000 232 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(2), GGT1(2), GPX2(1), GSTA2(1), GSTM3(1), GSTO2(2), OPLAH(1) 16153349 10 10 10 2 2 3 2 1 2 0 0.270 0.509 1.000 233 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), MPO(1), PRDX1(1), PRDX6(1), TPO(1) 7106918 5 5 5 2 1 1 1 1 1 0 0.835 0.509 1.000 234 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(1) 3944908 2 2 2 1 0 0 0 2 0 0 0.853 0.510 1.000 235 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(2) 5301407 2 2 2 0 1 0 0 1 0 0 0.572 0.512 1.000 236 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 CS(1), MTHFD1(2), MTHFD1L(1) 9436114 4 4 4 0 0 2 1 0 1 0 0.232 0.512 1.000 237 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA4(1), PSMA6(1), PSMB7(1) 6434195 3 3 3 0 1 1 0 1 0 0 0.378 0.517 1.000 238 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(1), KARS(1) 5121422 2 2 2 1 1 0 0 1 0 0 0.826 0.533 1.000 239 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), IL11(1) 4464837 2 2 2 0 1 0 0 0 1 0 0.651 0.537 1.000 240 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(1), XYLT2(1) 4860934 2 2 2 1 0 0 0 1 1 0 0.756 0.540 1.000 241 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(1), XYLT2(1) 4860934 2 2 2 1 0 0 0 1 1 0 0.756 0.540 1.000 242 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(5), AKT2(1), AKT3(1), ANGPTL2(1), ARHGAP4(3), ARHGEF11(1), CDC42(1), GDI1(1), GDI2(1), ITPR1(2), ITPR2(6), MYLK(4), PAK3(2), PAK7(2), PIK3CA(3), PIK3CD(2), PIK3CG(1), PIK3R1(2), PITX2(2), PPP1R13B(1), PTEN(2), RPS4X(1), WASL(1) 51748712 46 43 44 8 10 7 2 19 7 1 0.0270 0.541 1.000 243 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(1) 2892339 1 1 1 0 0 1 0 0 0 0 0.624 0.544 1.000 244 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(5), ABLIM2(1), CDC42(1), CDK5(1), DCC(2), DPYSL5(2), EPHA4(1), EPHA6(2), EPHB1(2), EPHB6(1), FYN(1), HRAS(17), ITGB1(2), KRAS(5), LRRC4C(2), MET(2), NCK1(2), NFAT5(3), NFATC1(1), NFATC4(3), NGEF(3), NRAS(40), NRP1(2), NTN4(1), PAK3(2), PAK7(2), PLXNA2(1), PLXNA3(1), PLXNB1(3), PLXNB2(1), PLXNB3(2), PLXNC1(2), RASA1(2), ROBO2(2), SEMA3A(1), SEMA4B(1), SEMA5B(1), SEMA6A(1), SEMA6B(1), SEMA6C(1), SEMA7A(3), SLIT1(1), SLIT2(2), SLIT3(1), SRGAP1(1), UNC5A(2), UNC5B(1), UNC5C(1), UNC5D(1) 145788731 139 126 81 25 13 16 57 43 10 0 0.000846 0.546 1.000 245 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1) 3621752 1 1 1 0 0 0 0 0 1 0 0.826 0.549 1.000 246 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 GOT1(1), GOT2(2), LDHA(2), SDS(1) 9242361 6 6 6 2 2 0 1 3 0 0 0.632 0.552 1.000 247 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), ITGAL(4), ITGB2(1) 7903520 7 7 7 3 2 2 2 0 1 0 0.595 0.554 1.000 248 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 KARS(1) 3474696 1 1 1 1 1 0 0 0 0 0 0.904 0.555 1.000 249 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(1), POLE(1), POLL(1), POLQ(2) 12337124 6 6 6 1 1 2 0 2 1 0 0.293 0.559 1.000 250 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(5), EIF4G1(1), EIF4G2(1), EIF4G3(1), PIK3CA(3), PIK3R1(2), PTEN(2) 20352875 15 14 13 3 0 4 2 6 2 1 0.296 0.560 1.000 251 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1) 2244019 1 1 1 0 1 0 0 0 0 0 0.686 0.575 1.000 252 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 TNFRSF1A(1), TNFRSF1B(1), TRADD(1) 6161617 3 3 3 1 1 0 0 1 1 0 0.787 0.585 1.000 253 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR24(1), MVD(1), SQLE(1), TM7SF2(2) 14174312 6 6 6 1 2 0 1 1 2 0 0.442 0.587 1.000 254 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(1), JAK1(1), JAK2(1), PLA2G2A(1), PTPRU(1), STAT1(1) 8440008 6 6 6 2 1 1 1 2 1 0 0.647 0.589 1.000 255 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 JUN(1), MAP3K1(3), TNFRSF9(1), TNFSF9(1) 14213994 6 6 6 1 2 0 0 1 3 0 0.561 0.592 1.000 256 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(4), CASP6(1), JUN(1), MAP3K1(3), MAPK10(1), MYC(1), TNFRSF1A(1), TNFRSF1B(1), TP53(4), TRADD(1), TRAF1(1) 27557223 19 19 19 4 2 2 2 6 7 0 0.391 0.593 1.000 257 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(1), PCYT1A(1), PDHA2(1) 5153896 3 3 3 2 1 0 0 0 2 0 0.913 0.619 1.000 258 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 2297706 1 1 1 0 0 0 0 0 1 0 0.627 0.620 1.000 259 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1B(1), ADH4(1), ADH7(2), AKR1C3(2), CYP1A2(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), GSTA2(1), GSTM3(1), GSTO2(2), UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2) 42215502 23 22 23 3 2 5 5 10 1 0 0.0632 0.621 1.000 260 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 ERBB3(3) 7592833 3 3 3 0 0 2 1 0 0 0 0.294 0.626 1.000 261 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 LPL(1) 3931077 1 1 1 0 0 1 0 0 0 0 0.618 0.630 1.000 262 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ASL(1), CKM(2), CPS1(1) 12932520 5 5 5 1 2 2 0 0 0 1 0.330 0.631 1.000 263 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF1A2(1), EEF2K(1), EIF1AX(8), EIF2AK2(1), EIF2B4(1), EIF2S2(1), EIF4G1(1), EIF4G3(1), ETF1(2), PABPC1(1), PABPC3(1) 32195218 19 18 18 3 1 6 2 7 2 1 0.138 0.632 1.000 264 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1) 2267484 1 1 1 1 0 0 0 1 0 0 0.952 0.637 1.000 265 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 HADHA(1), SDS(1) 5760037 2 2 2 1 1 0 0 1 0 0 0.871 0.640 1.000 266 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 PTPRA(1), SRC(2) 6789138 3 3 3 0 2 0 0 1 0 0 0.388 0.642 1.000 267 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYS(2), ENPP1(2), PPCS(1) 10263288 6 6 5 3 1 1 0 0 4 0 0.923 0.644 1.000 268 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 HADHA(1), SDS(1) 6170592 2 2 2 1 1 0 0 1 0 0 0.869 0.649 1.000 269 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOB(1), FPGT(1), FUK(1), GMDS(1), HK2(3), HK3(1), HSD3B7(1), PFKFB3(1), PFKFB4(1), PFKP(2), PGM2(1), PMM2(1), RDH14(1) 27430811 16 16 16 3 3 3 5 2 3 0 0.151 0.650 1.000 270 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 PLA2G2A(1), PLA2G5(2), PLA2G6(1) 7468364 4 3 4 0 1 0 1 2 0 0 0.356 0.651 1.000 271 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1B(1), ADH4(1), ADH7(2), AOC3(1), AOX1(1), DCT(1), DDC(1), ESCO2(2), GOT1(1), GOT2(2), HGD(1), HPD(1), LCMT1(2), METTL2B(1), PRMT3(1), PRMT8(3), TAT(1), TPO(1), TYRP1(1) 43862759 25 24 24 4 6 4 5 7 3 0 0.0892 0.653 1.000 272 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3D(1), ITGAL(4), ITGB2(1) 6460718 6 6 6 3 2 2 1 0 1 0 0.651 0.655 1.000 273 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1) 2975128 1 1 1 0 0 1 0 0 0 0 0.668 0.656 1.000 274 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ARRB2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CLCA4(1), CNGA4(1), CNGB1(4), GNAL(2), GUCA1A(1), PRKG1(1) 22494515 15 15 15 4 2 4 2 3 4 0 0.383 0.658 1.000 275 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK2(3), HK3(1), ISYNA1(2) 8605392 6 6 6 3 1 1 0 1 3 0 0.838 0.658 1.000 276 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 EIF2S2(1), TP53(4) 7185335 5 5 5 2 0 0 0 2 3 0 0.778 0.659 1.000 277 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(1), CREBBP(1) 7807571 3 3 3 0 0 1 0 0 2 0 0.516 0.663 1.000 278 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(1), ITGAL(4), ITGAM(2), ITGB1(2), ITGB2(1) 11705271 10 10 10 4 3 4 1 1 1 0 0.539 0.665 1.000 279 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(5), AKT2(1), AKT3(1), CDKN2A(1), FLOT2(1), ITPR1(2), ITPR2(6), LYN(1), PIK3CA(3), PITX2(2), PPP1R13B(1), PTEN(2), RPS6KA1(1), SYK(1) 40646088 28 28 26 5 5 5 2 7 8 1 0.0907 0.669 1.000 280 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(1), CYP11B1(2), HSD11B2(1), HSD17B3(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A3(2), UGT1A4(1) 20184524 12 12 12 3 1 2 5 2 2 0 0.276 0.671 1.000 281 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2), XYLB(1) 20050121 9 8 9 1 0 2 3 3 1 0 0.179 0.674 1.000 282 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT2(1), AGPS(1), CDS2(1), CHAT(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), GNPAT(4), LGALS13(1), PCYT1A(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCB2(1), PLCG1(1), PPAP2C(1) 36747616 27 26 27 5 6 4 4 5 8 0 0.168 0.675 1.000 283 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH5A1(1), CAD(1), CPS1(1), EPRS(2), GAD2(1), GFPT1(1), GMPS(1), GOT1(1), GOT2(2), GPT(1), NADSYN1(1), PPAT(1) 24427778 15 14 15 3 3 6 1 3 1 1 0.193 0.675 1.000 284 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 HIF1A(1), JUN(1), LDHA(2), P4HB(1) 12472960 5 5 5 0 1 0 2 2 0 0 0.222 0.677 1.000 285 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1R(2) 4845221 2 2 2 1 0 0 0 1 1 0 0.742 0.677 1.000 286 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(5), AKT2(1), AKT3(1), BAD(1), IRS1(3), IRS2(2), JAK1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(1), SOS1(2), SOS2(2), STAT6(1) 26960729 28 28 26 7 3 8 1 12 4 0 0.308 0.681 1.000 287 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), CHSY1(1), DSE(1), XYLT2(1) 10369141 4 4 4 1 1 1 0 1 1 0 0.489 0.687 1.000 288 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 HMGB1(2) 6386501 2 2 2 3 0 0 0 0 2 0 1.000 0.690 1.000 289 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(1), C2(2), C3(1), C5(1), C6(1), C7(2) 12823924 9 9 9 3 2 0 0 4 3 0 0.782 0.690 1.000 290 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRB1(1), CHRM4(1), CHRM5(1), DRD4(2), DRD5(3), HRH1(1), HRH2(1), HTR2B(1), HTR5A(1) 18962620 13 12 13 3 2 3 1 7 0 0 0.269 0.692 1.000 291 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 CS(1), FH(1), IDH3B(1), PC(3), SDHA(1) 15209999 7 6 7 0 2 2 1 2 0 0 0.0848 0.702 1.000 292 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), MAP2K1(1), MAP3K1(3), NSMAF(1), TNFRSF1A(1), TRADD(1) 15123714 8 8 8 2 1 0 0 2 5 0 0.791 0.702 1.000 293 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNGT1(1), PLCB1(1) 5271817 2 2 2 0 0 0 0 2 0 0 0.699 0.702 1.000 294 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), TF(2) 9417302 3 3 3 1 1 1 1 0 0 0 0.579 0.709 1.000 295 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 GNGT1(1), PIK3CA(3), PIK3R1(2), PLCB1(1), PPP1R12B(1), PTK2B(2) 19034228 10 10 10 2 0 3 0 5 2 0 0.405 0.710 1.000 296 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CLOCK(1), CRY1(1), EIF4G2(1), GSTM3(1), HSPA8(1), NCOA4(1), PSMA4(1), PURA(1), SF3A3(1), SUMO3(3), VAPA(1) 26906139 13 13 11 2 1 3 1 4 4 0 0.353 0.710 1.000 297 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH1B(1), ADH4(1), ADH7(2), ESCO2(2) 18403396 7 7 7 1 1 0 1 4 1 0 0.490 0.711 1.000 298 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(3), LARS(1), PDHA2(1) 7381590 6 6 6 3 1 1 1 1 2 0 0.859 0.712 1.000 299 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 CFTR(2), GNAS(3), PRKAR2A(1) 9588826 6 6 6 2 1 0 2 3 0 0 0.756 0.717 1.000 300 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 HADH(1), HADHA(1), SIRT2(1), VNN2(2) 8767621 5 5 5 2 1 1 1 1 1 0 0.796 0.718 1.000 301 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 CTNNB1(2), SRC(2), VCL(2) 14111919 6 6 6 0 1 0 2 3 0 0 0.214 0.720 1.000 302 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(1), POLR2B(1) 9941645 4 4 4 0 0 1 0 1 2 0 0.349 0.723 1.000 303 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 SQLE(1) 3094535 1 1 1 1 0 0 0 0 1 0 0.885 0.727 1.000 304 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IL1R1(2), MAP3K1(3), TLR4(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(1) 17960744 9 9 9 2 1 2 1 2 3 0 0.470 0.730 1.000 305 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ENPP1(2) 7153214 2 2 2 1 0 1 0 0 1 0 0.877 0.731 1.000 306 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), PKLR(1) 6858781 2 2 2 1 1 1 0 0 0 0 0.659 0.731 1.000 307 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 CMA1(1), COL4A1(3), COL4A2(2), COL4A3(2), COL4A4(2), COL4A5(2), COL4A6(1) 18640996 13 13 13 4 2 2 2 4 3 0 0.464 0.735 1.000 308 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ITGAL(4), ITGAM(2), ITGB2(1) 7611878 8 8 8 4 3 3 1 0 1 0 0.651 0.737 1.000 309 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1) 4634726 1 1 1 0 0 0 0 0 1 0 0.838 0.740 1.000 310 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 HADHA(1) 3983338 1 1 1 1 0 0 0 1 0 0 0.972 0.740 1.000 311 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C5(1), C6(1), C7(2) 9210095 5 5 5 2 1 0 0 2 2 0 0.791 0.745 1.000 312 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(1), ESR1(1), SRC(2) 10867105 4 4 4 1 1 0 0 1 2 0 0.570 0.753 1.000 313 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH4(1), ADH7(2), ALDH2(1) 9765565 5 5 5 2 1 0 0 4 0 0 0.767 0.758 1.000 314 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11A1(2), CYP11B1(2), HSD11B2(1) 6813188 6 6 6 3 1 3 0 2 0 0 0.649 0.760 1.000 315 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11A1(2), CYP11B1(2), HSD11B2(1) 6813188 6 6 6 3 1 3 0 2 0 0 0.649 0.760 1.000 316 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(1), IFNGR1(1), IL12RB2(1), IL2RA(1) 9320561 5 5 5 2 3 0 1 1 0 0 0.590 0.761 1.000 317 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ALPI(1), ALPP(1), CYP19A1(1), CYP1A2(1), CYP2A13(2), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1) 21632956 10 10 10 2 1 2 2 5 0 0 0.299 0.762 1.000 318 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC2(1), APOBEC3G(1) 5395790 3 3 3 2 0 1 0 1 1 0 0.921 0.763 1.000 319 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(1), JAK1(1), JAK2(1), STAT1(1) 6033137 4 4 4 2 1 1 0 2 0 0 0.800 0.765 1.000 320 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 HSD3B7(1), RDH14(1) 6635917 2 2 2 0 1 0 0 1 0 0 0.555 0.767 1.000 321 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(1), CPOX(1), EPRS(2), FECH(1), FTH1(1), HCCS(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2) 31136109 18 17 18 3 1 4 3 8 2 0 0.208 0.767 1.000 322 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT6(2), AGPS(1), ENPP2(3), ENPP6(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLD2(1), PPAP2C(1) 17085302 14 12 14 4 5 1 2 5 1 0 0.449 0.775 1.000 323 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 FGA(1), PLG(1), SERPINB2(1) 9888099 3 3 3 0 0 0 1 1 1 0 0.401 0.778 1.000 324 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 UGT1A1(1), UGT1A3(2), UGT1A4(1) 12930046 4 4 4 0 0 0 3 1 0 0 0.286 0.781 1.000 325 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ASL(1), CKM(2), CPS1(1), EPRS(2), GOT1(1), GOT2(2), NOS1(1) 26490068 10 10 10 1 3 1 0 4 1 1 0.202 0.787 1.000 326 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(1) 4483684 1 1 1 0 1 0 0 0 0 0 0.664 0.788 1.000 327 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 GNAS(3), GNGT1(1), PRKAG2(1), PRKAR2A(1) 11271996 6 6 6 2 1 1 1 3 0 0 0.658 0.790 1.000 328 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(2), HSD11B2(1) 5099606 3 3 3 2 0 2 0 1 0 0 0.782 0.794 1.000 329 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), CRY1(1) 6275462 2 2 2 1 0 1 0 0 1 0 0.901 0.796 1.000 330 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 HEXA(1), HEXB(1), LCT(1) 10635132 3 3 3 1 1 0 1 0 1 0 0.612 0.800 1.000 331 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1) 3647302 1 1 1 0 0 0 0 1 0 0 0.836 0.800 1.000 332 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 MVD(1), SQLE(1) 8103444 2 2 2 0 1 0 0 0 1 0 0.412 0.804 1.000 333 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 GNGT1(1), MYLK(4), PLCB1(1), PPP1R12B(1) 15210788 7 7 7 2 3 1 0 2 1 0 0.482 0.804 1.000 334 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR1B(2), POLR2A(1), POLR2B(1), POLR3B(1) 17301507 6 6 6 0 1 1 0 2 2 0 0.215 0.804 1.000 335 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), DPYS(2), ENPP1(2), PPCS(1) 12748040 6 6 5 3 1 1 0 0 4 0 0.920 0.806 1.000 336 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFS1(1), NDUFV2(1) 5114727 2 2 2 2 0 0 1 0 1 0 0.894 0.808 1.000 337 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 UBE2F(1) 4743330 1 1 1 0 0 1 0 0 0 0 0.643 0.809 1.000 338 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(1), ITGAL(4), ITGB1(2), ITGB2(1) 8896378 8 8 8 4 1 4 1 1 1 0 0.718 0.809 1.000 339 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(1), CYP11B1(2), CYP19A1(1), HSD11B2(1), HSD17B1(1), HSD17B3(1), LCMT1(2), METTL2B(1), PRMT3(1), PRMT8(3), STS(1), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2) 37027617 25 23 24 5 2 6 7 7 3 0 0.0774 0.815 1.000 340 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(1), C2(2), C3(1), C5(1), C6(1), C7(2) 15254383 9 9 9 3 2 0 0 4 3 0 0.779 0.820 1.000 341 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 CPT1A(3), HADHA(1) 12415194 4 4 4 1 1 0 0 2 1 0 0.599 0.821 1.000 342 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 JUN(1), POLR2A(1), PRKAR2A(1) 9508864 3 3 3 0 1 1 1 0 0 0 0.294 0.823 1.000 343 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH2(1), AMDHD1(2), AOC3(1), DDC(1), LCMT1(2), METTL2B(1), PRMT3(1), PRMT8(3), PRPS1(2), UROC1(1) 29238477 15 15 14 3 4 3 3 3 2 0 0.170 0.824 1.000 344 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 JUN(1), MAP2K6(1), MAP3K1(3), PPARA(1), TLR2(1), TLR3(1), TLR4(1), TLR7(1) 27036376 10 10 10 1 1 0 2 4 3 0 0.316 0.825 1.000 345 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(2), MAP2(1), PRKAR2A(1) 13336180 4 4 4 0 0 0 3 0 1 0 0.240 0.825 1.000 346 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC3(1), CES1(1), ESCO2(2), PLA1A(1), PRDX6(1) 18657078 6 6 6 0 0 1 2 2 1 0 0.210 0.829 1.000 347 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(1), C2(2), C3(1), C5(1), C6(1), C7(2) 15628880 9 9 9 3 2 0 0 4 3 0 0.774 0.837 1.000 348 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(1), ST8SIA1(1) 4509747 3 3 3 2 0 0 3 0 0 0 0.899 0.842 1.000 349 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), FYN(1), RELN(2), VLDLR(1) 10331411 5 5 5 2 0 1 1 1 2 0 0.889 0.844 1.000 350 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 IL11(1) 6093709 1 1 1 1 0 0 0 0 1 0 1.000 0.845 1.000 351 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CTBS(1), GFPT1(1), HEXA(1), HEXB(1), HK2(3), HK3(1), NANS(1), RENBP(1) 21176778 10 9 10 2 1 2 2 3 2 0 0.286 0.847 1.000 352 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK2A(1), CAMK2B(1), CAMKK2(1), SYT1(1) 8517816 4 4 4 3 1 1 0 0 2 0 0.945 0.849 1.000 353 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), PDE1A(1), PLCB1(1), PLCB2(1) 8197779 4 4 4 2 1 0 0 2 1 0 0.742 0.852 1.000 354 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), GOT1(1), GOT2(2), GPT(1), ME1(1), PKLR(1), RPIA(1) 13299464 8 8 8 3 3 1 1 3 0 0 0.593 0.854 1.000 355 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH5A1(1), CAD(1), CPS1(1), EPRS(2), GAD2(1), GFPT1(1), GMPS(1), GOT1(1), GOT2(2), GPT(1), NADSYN1(1), PPAT(1) 29092993 15 14 15 3 3 6 1 3 1 1 0.179 0.856 1.000 356 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA4(1), PSMA6(1), PSMB7(1) 11786941 3 3 3 0 1 1 0 1 0 0 0.393 0.864 1.000 357 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(5), CDC42(1), EEF2K(1), IL1R1(2), MAP2K6(1) 24662537 10 10 8 2 0 5 0 5 0 0 0.345 0.870 1.000 358 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(5), EIF4G1(1), EIF4G2(1), EIF4G3(1), GHR(1), IRS1(3), PABPC1(1), PIK3CA(3), PIK3R1(2), PTEN(2) 20756642 20 19 18 5 1 4 3 9 2 1 0.449 0.870 1.000 359 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 MVD(1), SQLE(1) 9664755 2 2 2 0 1 0 0 0 1 0 0.431 0.870 1.000 360 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 XDH(1) 7324689 1 1 1 1 0 0 0 1 0 0 0.933 0.874 1.000 361 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(1), CRHR1(1), ELTD1(1), EMR2(1), GLP2R(2), LPHN2(1), LPHN3(2) 19600742 10 10 10 3 4 1 2 2 1 0 0.450 0.883 1.000 362 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(1), DDC(1), GAD2(1) 10633084 3 3 3 0 1 1 0 0 1 0 0.316 0.886 1.000 363 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 AKT1(5), GNGT1(1), ITGAV(1), ITGB3(1), PIK3CA(3), PIK3R1(2), PLCB1(1), SMPD2(1), SRC(2) 20217647 17 15 15 5 1 4 0 10 2 0 0.514 0.886 1.000 364 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), AKT1(5), ANGPTL2(1), CDC42(1), FLNA(1), FLNC(4), FSCN1(1), GDI1(1), GDI2(1), MYH2(2), MYLK(4), PAK3(2), PAK7(2), RPS4X(1), WASL(1) 35316442 28 28 26 7 5 6 2 13 2 0 0.199 0.886 1.000 365 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNGR1(1), JAK2(1), RB1(2), TNFRSF1A(1), TNFRSF1B(1), TP53(4), WT1(1) 13363330 11 10 11 4 3 1 0 4 3 0 0.604 0.888 1.000 366 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 DARS(1), EPRS(2), FARSA(1), GARS(1), IARS(3), KARS(1), LARS(1), MARS(1), MARS2(1), TARS(1), VARS(1), VARS2(1), WARS(1) 40022460 16 16 16 2 3 2 3 5 3 0 0.163 0.889 1.000 367 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 MAP3K1(3), TNFRSF1B(1), TRAF1(1) 16548975 5 5 5 1 0 0 0 3 2 0 0.694 0.890 1.000 368 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 HEXA(1), HEXB(1), LCT(1), SPAM1(1) 15126918 4 4 4 1 1 0 1 1 1 0 0.569 0.890 1.000 369 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT3(1), B3GNT5(1), FUT1(1), FUT3(2), ST8SIA1(1) 11918832 7 7 7 3 0 0 4 1 2 0 0.743 0.890 1.000 370 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(1), NCOA3(1), PRKAR2A(1), RARA(1) 15231604 4 4 4 1 0 0 2 0 2 0 0.688 0.891 1.000 371 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(1), ITPR1(2), ITPR2(6), NFAT5(3), TF(2) 26337316 15 14 15 4 6 2 0 3 4 0 0.315 0.896 1.000 372 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1) 5806248 1 1 1 1 0 0 1 0 0 0 0.929 0.896 1.000 373 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), FCGR2B(1), HLA-DRA(1), ITGAL(4), ITGB2(1) 11139018 8 8 8 4 2 2 2 1 1 0 0.738 0.907 1.000 374 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 PRKAR2A(1) 7432882 1 1 1 1 0 0 1 0 0 0 0.888 0.907 1.000 375 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(2), COL4A3(2), COL4A4(2), COL4A5(2), COL4A6(1), P4HB(1), SLC23A2(1) 18515689 14 14 14 5 2 2 1 6 3 0 0.614 0.910 1.000 376 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 JUN(1), MAP2K6(1), MAP3K1(3), TNFRSF1A(1), TRADD(1) 17742937 7 7 7 2 2 0 0 2 3 0 0.693 0.910 1.000 377 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 OAZ1(1), POLB(1), POLD1(1), RRM1(1) 9237868 4 4 4 2 2 0 0 1 1 0 0.845 0.910 1.000 378 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(1), ACACB(1), FASN(1) 11636943 3 3 3 1 2 0 0 1 0 0 0.743 0.913 1.000 379 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPNS2(1), CDK5(1) 6771346 2 2 2 3 0 0 1 0 1 0 0.998 0.915 1.000 380 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 JUNB(1), NFATC1(1), PRKAR2A(1) 8964782 3 3 3 2 1 0 1 0 1 0 0.872 0.915 1.000 381 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK2(3), HK3(1) 7542916 4 4 4 3 1 1 0 1 1 0 0.846 0.917 1.000 382 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 FH(1) 6566149 1 1 1 0 0 0 0 1 0 0 0.833 0.917 1.000 383 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAD9(1), ADH1B(1), ADH4(1), ADH7(2), AKR1D1(1), ALDH2(1), CEL(1), HSD3B7(1), RDH14(1), SOAT1(1) 23309720 11 11 11 3 2 2 0 7 0 0 0.487 0.917 1.000 384 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 PLCB1(1) 6062656 1 1 1 0 0 0 0 1 0 0 0.843 0.918 1.000 385 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(3), CREBBP(1), MAP2K1(1), TGFBR1(1), TGFBR2(1) 18937222 7 7 7 2 0 0 2 2 3 0 0.746 0.922 1.000 386 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(3), LARS(1), PDHA2(1), VARS(1), VARS2(1) 13713780 8 8 8 3 2 1 1 1 3 0 0.782 0.923 1.000 387 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(1), ALDH2(1), AMD1(1), AOC3(1), ASL(1), CPS1(1) 21777206 6 6 6 1 1 1 1 2 0 1 0.343 0.925 1.000 388 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAPK10(1), MAPK8IP2(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), SYT1(1) 24754643 10 10 10 2 2 1 0 4 3 0 0.425 0.926 1.000 389 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(1) 7269083 1 1 1 0 0 1 0 0 0 0 0.569 0.929 1.000 390 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(4), SCAP(1), SREBF1(1), SREBF2(1) 13444273 7 7 7 3 1 3 1 1 1 0 0.756 0.929 1.000 391 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK4(1), EIF2S2(1) 8490835 2 2 2 2 0 0 0 1 1 0 0.955 0.933 1.000 392 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), HEXA(1), HEXB(1), ST8SIA1(1) 7467968 4 4 4 4 0 0 3 0 1 0 0.977 0.935 1.000 393 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(2), COL4A3(2), COL4A4(2), COL4A5(2), COL4A6(1), F10(2), F8(3), F9(1), FGA(1), PROC(1), PROS1(2) 32809566 22 22 22 6 5 2 2 8 5 0 0.356 0.935 1.000 394 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLB(1), POLD1(1), POLD3(1), POLE(1), POLE2(1), POLL(1), POLQ(2), REV1(1), REV3L(1) 29820048 10 9 10 1 1 3 0 3 3 0 0.237 0.937 1.000 395 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 MAP3K1(3) 13359934 3 3 3 1 0 0 0 1 2 0 0.826 0.940 1.000 396 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(3), ARHGAP6(1), ARHGEF11(1), ARPC1B(1), GSN(1), MYLK(4), PIP5K1A(1), PPP1R12B(1), SRC(2), TLN1(1), VCL(2) 33635020 18 18 18 4 5 3 1 4 5 0 0.181 0.943 1.000 397 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(1) 8046768 1 1 1 2 0 0 0 0 1 0 0.921 0.943 1.000 398 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CDKN2A(1) 6655295 1 1 1 0 0 0 0 0 1 0 0.676 0.945 1.000 399 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT1(1), HEXA(1), HEXB(1), ST8SIA1(1) 7926469 4 4 4 4 0 0 3 0 1 0 0.975 0.945 1.000 400 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 HEXA(1), HEXB(1), LCT(1), MAN2B1(2), MAN2C1(1), MANBA(1) 15035748 7 7 7 3 2 1 1 0 3 0 0.779 0.946 1.000 401 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH2(1) 6288109 1 1 1 1 0 0 0 1 0 0 0.940 0.949 1.000 402 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), BECN1(1), ULK3(1) 15557025 3 3 3 1 1 0 0 1 1 0 0.753 0.952 1.000 403 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), HIF1A(1), JAK2(1) 9319039 3 3 3 2 1 0 1 1 0 0 0.850 0.952 1.000 404 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(4), MAPKAPK3(1) 8360146 6 6 6 4 1 2 1 1 1 0 0.856 0.955 1.000 405 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(2), FYN(1), ITGB1(2), LYN(1) 11662640 8 8 8 4 0 3 1 3 1 0 0.802 0.957 1.000 406 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1B(1), GLI2(3), GLI3(1), PRKAR2A(1), SUFU(1) 12264258 7 7 7 5 3 1 1 0 2 0 0.769 0.959 1.000 407 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK1(1), JAK2(1), PIAS3(1), PTPRU(1), SRC(2) 11229393 6 6 6 3 2 1 1 1 1 0 0.799 0.959 1.000 408 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(3), AXIN1(1), CREBBP(1), CTNNB1(2), LEF1(1), PITX2(2), TRRAP(3) 24482489 13 13 13 4 1 1 2 6 3 0 0.632 0.960 1.000 409 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), GOT1(1), GOT2(2), GPT(1), ME1(1), PKLR(1), RPIA(1), TKTL2(1) 14874982 9 9 9 4 3 1 1 4 0 0 0.693 0.960 1.000 410 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 GPRC5B(2), GPRC5D(1), GRM1(3), GRM2(1), GRM4(2) 15493175 9 8 9 4 1 3 1 3 1 0 0.694 0.962 1.000 411 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), HLA-DRA(1), IL11(1) 9789059 3 3 3 5 2 0 0 0 1 0 0.993 0.962 1.000 412 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 GNAS(3), PRKAR2A(1) 10857093 4 4 4 2 1 0 1 2 0 0 0.832 0.963 1.000 413 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IL1R1(2), IRAK2(1), IRAK3(1), JUN(1), MAP2K6(1), MAP3K1(3) 21918869 9 9 9 3 2 2 1 2 2 0 0.617 0.964 1.000 414 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 JUN(1), MAP3K3(3), TNFRSF1A(1), TNFRSF1B(1), TRADD(1) 20044085 7 7 7 2 2 2 0 2 1 0 0.523 0.966 1.000 415 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD5(2), ITGAX(1), TLR2(1), TLR4(1), TLR7(1) 13732064 8 8 8 4 1 2 2 2 1 0 0.711 0.967 1.000 416 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(5), AKT2(1), AKT3(1), ARHGEF11(1), CDC42(1), MAP3K1(3), PHKA2(3), PIK3CB(1), PLD2(1) 36114268 17 17 15 4 2 5 0 6 4 0 0.359 0.967 1.000 417 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AFMID(1), ALDH2(1), AOC3(1), AOX1(1), ASMT(1), CYP1A2(1), DDC(1), HAAO(1), HADH(1), HADHA(1), LCMT1(2), LNX1(1), METTL2B(1), NFX1(1), OGDH(1), OGDHL(2), PRMT3(1), PRMT8(3), TDO2(2), TPH2(1), WARS(1) 44695625 26 26 25 6 4 2 7 11 2 0 0.251 0.968 1.000 418 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(4), BAD(1), CASP6(1), HELLS(1), IRF1(1), IRF3(1), IRF4(1), IRF5(2), JUN(1), MAP3K1(3), MAPK10(1), MYC(1), TNFRSF1A(1), TNFRSF1B(1), TP53(4), TP73(3), TRADD(1), TRAF1(1) 42333345 29 28 29 7 2 6 4 8 9 0 0.294 0.968 1.000 419 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(1), PIGO(1), PIGS(1), PIGZ(2) 17475844 5 5 5 2 0 3 1 0 1 0 0.638 0.969 1.000 420 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1) 6858288 1 1 1 1 1 0 0 0 0 0 0.849 0.969 1.000 421 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ALDH2(1), AOC3(1), DPYS(2), GAD2(1), HADHA(1), MLYCD(1) 19923352 8 8 7 3 0 2 1 3 2 0 0.799 0.971 1.000 422 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 ESCO2(2) 12214026 2 2 2 0 0 0 1 0 1 0 0.680 0.971 1.000 423 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(5), AKT2(1), AKT3(1), BAD(1), LYN(1), MAP2K1(1), NFAT5(3), PIK3CA(3), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(1), SOS1(2), SOS2(2), SYK(1) 38858048 27 26 25 7 3 6 2 9 7 0 0.304 0.972 1.000 424 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ALDH2(1), ALDH5A1(1), BDH1(2), GAD2(1), HADH(1), HADHA(1), HSD3B7(1), PDHA2(1), PLA1A(1), PRDX6(1), RDH14(1) 29929030 14 14 14 4 4 4 0 6 0 0 0.411 0.972 1.000 425 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(1), TYK2(1) 8640570 3 3 3 2 1 1 0 1 0 0 0.830 0.973 1.000 426 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ALAS1(1), AOC3(1), DMGDH(1), GARS(1), GCAT(1), HSD3B7(1), PHGDH(1), PSAT1(1), RDH14(1), SARDH(1), SDS(1), TARS(1) 31552874 12 11 12 3 2 2 2 5 1 0 0.445 0.973 1.000 427 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(4), CASP6(1) 9907959 5 5 5 3 0 2 1 1 1 0 0.925 0.975 1.000 428 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 JUN(1), MAP3K1(3), PRKDC(5), RB1(2), SPTAN1(1), TNFRSF1A(1), TRADD(1) 28279730 14 13 14 4 3 2 1 2 6 0 0.485 0.975 1.000 429 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1) 11084440 5 5 5 3 0 1 1 2 1 0 0.895 0.976 1.000 430 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1) 11084440 5 5 5 3 0 1 1 2 1 0 0.895 0.976 1.000 431 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1) 11084440 5 5 5 3 0 1 1 2 1 0 0.895 0.976 1.000 432 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(1), PIAS3(1), PTPRU(1), SOAT1(1) 10076489 5 5 5 3 1 2 1 0 1 0 0.819 0.976 1.000 433 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(3), CAMP(1), JUN(1), MAPK10(1), MAPK8IP2(1) 21076279 7 7 7 2 3 0 0 3 1 0 0.503 0.977 1.000 434 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(1), JAK1(1), JAK2(1), STAT1(1), STAT5B(1), TYK2(1) 13551184 6 6 6 3 2 1 0 2 1 0 0.759 0.977 1.000 435 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C5(1), C6(1), C7(2), ITGAL(4), ITGB1(2), ITGB2(1), VCAM1(2) 18227339 14 14 14 7 2 3 1 5 3 0 0.832 0.977 1.000 436 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR2(1) 8169135 1 1 1 0 0 0 0 1 0 0 0.836 0.978 1.000 437 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ALPI(1), ALPP(1) 13296879 2 2 2 1 0 1 0 1 0 0 0.767 0.978 1.000 438 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10A(1), RPL12(1), RPL13A(1), RPL18A(1), RPL22L1(1), RPL36AL(1), RPL9(2), RPS2(1) 16516526 9 8 9 3 1 4 0 4 0 0 0.635 0.979 1.000 439 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR2A(1), ACVR2B(1), AMHR2(1), BMP6(2), CREBBP(1), CUL1(2), GDF6(1), ID2(1), ID4(1), INHBA(2), INHBC(1), INHBE(1), LEFTY1(1), LTBP1(4), MYC(1), NODAL(1), PITX2(2), PPP2R1A(3), PPP2R1B(1), PPP2R2B(1), RBL1(1), RBL2(1), RPS6KB2(1), SMURF2(1), SP1(1), TGFBR1(1), TGFBR2(1), THBS1(1), THBS2(2), THBS3(1), THBS4(1), ZFYVE16(1) 72886573 42 38 41 7 5 11 8 6 12 0 0.0281 0.980 1.000 440 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(1), GALNT2(1), GALNT7(1), GALNT8(1) 10649611 4 4 4 3 2 0 0 1 1 0 0.950 0.980 1.000 441 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(5), FLT4(1), KDR(2), PDE2A(1), PDE3A(1), PRKAR2A(1), PRKG1(1), RYR2(4), SYT1(1) 29656106 18 17 16 5 1 7 2 6 2 0 0.305 0.981 1.000 442 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ENPP1(2) 11077671 2 2 2 2 0 1 0 0 1 0 0.959 0.981 1.000 443 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASRGL1(1), CA13(2), CPS1(1) 15656226 4 4 4 2 0 1 1 1 0 1 0.741 0.982 1.000 444 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1) 11796147 5 5 5 3 0 1 1 2 1 0 0.895 0.982 1.000 445 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 MAP3K1(3), MYC(1), NFATC1(1), PLCG1(1), PRKAR2A(1), SYT1(1) 20619531 8 8 8 3 2 1 2 1 2 0 0.611 0.983 1.000 446 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH2(1), AMD1(1), AOC3(1), ASL(1), CKM(2), CPS1(1), GOT1(1), GOT2(2), NOS1(1), P4HB(1) 32642616 12 12 12 3 3 1 1 6 0 1 0.399 0.984 1.000 447 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 OCRL(2), PIK3C2A(1), PIK3C2G(1), PIK3CA(3), PIK3CB(1), PIK3CG(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1) 32871640 15 14 15 4 2 1 2 7 3 0 0.511 0.986 1.000 448 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(5), AKT2(1), AKT3(1), BAD(1), CDC42(1), CDKN2A(1), ERBB4(3), F2RL2(1), IGFBP1(1), IRS1(3), IRS2(2), MET(2), MYC(1), PAK3(2), PAK7(2), PARD3(1), PIK3CA(3), PIK3CD(2), PPP1R13B(1), PTEN(2), RPS6KA1(1), SHC1(1), SOS1(2), SOS2(2), YWHAE(1), YWHAG(1) 57102125 44 43 42 10 4 9 3 20 7 1 0.203 0.986 1.000 449 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(3), AXIN1(1), CREBBP(1), CSNK2A1(1), CTBP1(1), CTNNB1(2), MYC(1) 21629345 10 10 10 4 0 2 2 3 3 0 0.673 0.986 1.000 450 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(1), ACTG1(1), CDC42(1), CREBBP(1), CSNK2A1(1), CTNNA3(1), CTNNB1(2), CTNND1(1), ERBB2(1), FARP2(1), FYN(1), IGF1R(3), INSR(1), IQGAP1(1), LEF1(1), LMO7(1), MET(2), MLLT4(1), PARD3(1), PTPRB(2), PTPRJ(1), PVRL1(3), PVRL4(1), SNAI2(1), SRC(2), TCF7L1(4), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(2), VCL(2), WASL(1), YES1(1) 88331140 46 40 46 5 3 4 9 17 13 0 0.0234 0.986 1.000 451 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH2(1), CYP2C19(1), CYP2C9(1), ESCO2(2), HADHA(1) 22800209 6 6 6 2 1 0 2 2 1 0 0.759 0.987 1.000 452 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLAT(1), GOT1(1), GOT2(2), HK2(3), HK3(1), LDHA(2), PC(3), PDHA2(1), PDHX(1), PFKP(2), PKLR(1) 31342763 19 19 19 5 7 4 2 5 1 0 0.206 0.987 1.000 453 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP4A(1), ATP6V0C(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), COX7B(1), CYC1(1), NDUFA6(1), NDUFA7(2), NDUFA9(2), NDUFS1(1), NDUFS5(1), NDUFS8(1), NDUFV2(1), NDUFV3(1), SDHA(1), SDHD(1), UQCRC1(2), UQCRC2(1) 41104362 26 26 26 7 4 5 5 7 5 0 0.328 0.990 1.000 454 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F7(1), F8(3), F9(1), FGA(1), PLG(1), SERPINB2(1), VWF(1) 26053724 11 11 11 4 4 0 1 3 3 0 0.568 0.990 1.000 455 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), PFKP(2), PRPS1(2), RPIA(1), TKTL2(1) 17953879 7 7 7 3 2 2 0 3 0 0 0.672 0.990 1.000 456 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 HEXA(1), HEXB(1), LCT(1), MAN2C1(1), MANBA(1) 12194257 5 5 5 3 2 1 1 0 1 0 0.787 0.991 1.000 457 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CPS1(1) 14011107 1 1 1 2 0 0 0 0 0 1 0.967 0.991 1.000 458 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 HEXA(1), HEXB(1), LCT(1), SLC33A1(1), ST6GALNAC6(1), ST8SIA1(1) 12158921 6 6 6 4 1 1 3 0 1 0 0.835 0.991 1.000 459 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 AGPAT2(1), AGPAT6(2), CDS2(1), CHAT(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), ESCO2(2), GNPAT(4), PCYT1A(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLD2(1), PPAP2C(1), PTDSS2(1) 48077698 29 27 29 7 6 5 5 5 8 0 0.304 0.992 1.000 460 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ESCO2(2), HADHA(1) 19154606 3 3 3 1 0 0 1 1 1 0 0.887 0.993 1.000 461 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), PFKP(2), PRPS1(2), RPIA(1) 15126447 6 6 6 3 2 2 0 2 0 0 0.716 0.993 1.000 462 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(1), LPL(1) 13588924 2 2 2 2 0 1 0 0 1 0 0.923 0.993 1.000 463 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(1), MAP2K6(1), TGFBR1(1), TGFBR2(1), TLR2(1) 21857495 5 5 5 2 0 0 2 1 2 0 0.810 0.994 1.000 464 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ALDH2(1), AOC3(1), DPYS(2), GAD2(1), HADHA(1), MLYCD(1), SDS(1) 21439603 9 9 8 4 1 2 1 3 2 0 0.830 0.995 1.000 465 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD28(1), CD3D(1), DTYMK(1), FBXW7(1), LCK(1), NCK1(2), NFAT5(3), PAK3(2), PAK7(2), PLCG1(1), RASGRP1(1), SOS1(2), SOS2(2) 41021700 21 21 21 5 3 4 3 8 3 0 0.283 0.995 1.000 466 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 HEXA(1), HEXB(1), LCT(1), MAN2B1(2), MAN2C1(1), MANBA(1), SPAM1(1) 25442347 8 8 8 3 2 1 1 1 3 0 0.738 0.995 1.000 467 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(1) 16474772 4 4 4 2 1 0 0 1 2 0 0.889 0.995 1.000 468 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), INSR(1), ITCH(1), MAGI1(1), MAGI2(1), RERE(2) 17695704 8 8 8 4 1 2 3 0 2 0 0.796 0.996 1.000 469 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(4), CASP6(1) 14231875 5 5 5 4 0 2 1 1 1 0 0.960 0.996 1.000 470 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), GOSR2(1), STX4(1), VAMP3(1), VTI1A(1) 12285759 5 5 5 4 1 0 1 2 1 0 0.933 0.996 1.000 471 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK2A(1), CAMK2B(1), HDAC5(1), MEF2B(1), PPARA(1), SYT1(1) 14875428 6 6 6 6 2 1 1 1 1 0 0.987 0.996 1.000 472 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 CYP11A1(2), HSD11B2(1), PTGER4(1), S100A6(1) 15207613 5 5 5 3 1 2 0 2 0 0 0.836 0.996 1.000 473 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP6(1), JUN(1), MAP3K1(3), PRKDC(5), PTPN13(2), RB1(2), SPTAN1(1) 29639709 15 14 15 6 3 2 1 4 5 0 0.779 0.996 1.000 474 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(3), AXIN1(1), CTNNB1(2), DVL2(2), DVL3(1), FZD10(1), FZD3(1), FZD8(2), JUN(1), MAPK10(1), MYC(1), PPP2R5C(1), PRKD1(3), WNT11(1), WNT4(1), WNT5B(1) 44375304 23 23 23 6 7 2 6 6 2 0 0.247 0.997 1.000 475 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), CANT1(1), CTPS2(1), DPYS(2), DTYMK(1), ITPA(1), NT5E(1), POLB(1), POLD1(1), POLE(1), POLL(1), POLQ(2), POLR1B(2), POLR2A(1), POLR2B(1), RRM1(1), TK1(2), TXNRD1(1) 42282024 22 22 21 5 2 4 3 7 6 0 0.340 0.997 1.000 476 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(1), APOA4(1), LPL(1), LRP1(5), SOAT1(1) 20209877 9 9 8 4 2 3 0 3 1 0 0.625 0.997 1.000 477 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), CRY1(1), NPAS2(1) 12582294 3 3 3 5 0 2 0 0 1 0 0.993 0.997 1.000 478 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), MGAT2(1), MGAT3(1), RPN1(1) 14683852 5 5 5 3 1 2 0 2 0 0 0.823 0.997 1.000 479 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(5), AKT2(1), AKT3(1), BAD(1), FLOT2(1), INPP5D(1), ITPR1(2), ITPR2(6), LYN(1), NFATC1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(1), SOS1(2), SOS2(2), SYK(1) 54501461 34 33 32 9 8 7 2 9 8 0 0.219 0.998 1.000 480 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ATP6V0C(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), CDC42(1), JAM2(1), JUN(1), LYN(1), MAPK10(1), MET(2), PLCG1(1), PTPRZ1(7), SRC(2), TJP1(2) 51738118 26 24 26 6 4 2 5 12 3 0 0.349 0.998 1.000 481 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ADH1B(1), ADH4(1), ADH7(2), ALDH2(1), CPT1A(3), CPT1C(1), CYP4A11(2), HADH(1), HADHA(1) 36157238 13 12 12 4 4 2 0 6 1 0 0.500 0.998 1.000 482 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(5), AKT2(1), AKT3(1), APC(3), AXIN1(1), CTNNB1(2), DKK4(1), LRP1(5), NKD1(1), NKD2(1), PTPRA(1), SENP2(1) 29766622 23 23 20 8 4 6 1 8 4 0 0.571 0.998 1.000 483 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(3), AXIN1(1), CTNNB1(2), DLL1(1) 15837047 7 7 7 5 1 1 1 3 1 0 0.904 0.998 1.000 484 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ALAS1(1), AOC3(1), ATP6V0C(1), DMGDH(1), GARS(1), GCAT(1), PLCB2(1), PLCG1(1), SARDH(1), TARS(1) 31050110 10 8 10 3 2 2 2 3 1 0 0.539 0.998 1.000 485 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1B(1), ADH4(1), ADH7(2), AKR1D1(1), ALDH2(1), CEL(1) 17105790 7 7 7 4 1 1 0 5 0 0 0.862 0.998 1.000 486 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(5), ACTB(1), ACTG1(1), ARHGEF2(2), CDC42(1), CTNNB1(2), EZR(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCK1(2), NCL(1), OCLN(1), TLR4(1), TUBA3C(1), TUBB2B(1), WASL(1) 38766570 26 23 23 9 2 7 4 7 6 0 0.607 0.998 1.000 487 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(5), ACTB(1), ACTG1(1), ARHGEF2(2), CDC42(1), CTNNB1(2), EZR(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCK1(2), NCL(1), OCLN(1), TLR4(1), TUBA3C(1), TUBB2B(1), WASL(1) 38766570 26 23 23 9 2 7 4 7 6 0 0.607 0.998 1.000 488 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), CAPNS2(1), ITGB1(2), ITGB3(1), SPTAN1(1), SRC(2), TLN1(1) 20984933 9 9 9 4 2 2 1 3 1 0 0.724 0.998 1.000 489 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AKT1(5), AKT2(1), AKT3(1), APAF1(4), ATM(7), BAD(1), CASP6(1), CSF2RB(3), IL1R1(2), IRAK2(1), IRAK3(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PRKAR2A(1), TNFRSF1A(1), TP53(4), TRADD(1) 61570439 48 45 46 11 5 11 6 13 13 0 0.193 0.999 1.000 490 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(2), HS3ST2(1), NDST2(1), NDST3(1), NDST4(1) 15338941 7 7 7 6 1 1 1 3 1 0 0.953 0.999 1.000 491 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(4), CASP6(1), SPTAN1(1), TRADD(1) 24609412 7 7 7 5 0 2 1 1 3 0 0.960 0.999 1.000 492 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), NCOA3(1), NCOR2(1), POLR2A(1), RARA(1) 18344482 5 5 5 5 0 1 1 2 1 0 0.969 0.999 1.000 493 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(5), ATM(7), CDC6(1), CDC7(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(4), E2F3(1), ESPL1(2), HDAC5(1), HDAC8(1), MCM4(1), PRKDC(5), PTPRA(1), RB1(2), RBL1(1), TP53(4), WEE1(1) 80880193 41 37 38 8 3 7 4 13 14 0 0.194 0.999 1.000 494 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH2(1), AOC3(1), DDC(1), PRPS1(2) 18047993 5 5 5 3 2 0 1 2 0 0 0.836 0.999 1.000 495 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), BAD(1), CABIN1(1), CAMK2B(1), CDKN1A(1), CNR1(2), CREBBP(1), CSNK2A1(1), HRAS(17), IL2RA(1), JUNB(1), MEF2B(1), NFAT5(3), NFATC1(1), NFATC4(3), NUP214(3), RPL13A(1), SLA(4), SP1(1), VAV2(1) 67075344 46 43 31 11 7 3 17 10 9 0 0.188 0.999 1.000 496 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP7A(1), ATP7B(1), COX7B(1), NDUFS1(1), NDUFV2(1), SDHA(1), UQCRC1(2) 28130302 14 14 14 5 1 1 4 5 3 0 0.689 1.000 1.000 497 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(1), ALDH2(1), HADHA(1), LDHA(2), MLYCD(1), PCCA(1), SDS(1) 24418388 9 9 9 4 2 1 1 5 0 0 0.829 1.000 1.000 498 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 ALDH2(1), DOT1L(1), EHMT2(1), HADH(1), HADHA(1), HSD3B7(1), NSD1(4), OGDH(1), OGDHL(2), RDH14(1), SETD1A(3), SETDB1(1), TMLHE(1) 42870787 19 19 19 5 4 2 3 8 2 0 0.463 1.000 1.000 499 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC2(1), ANAPC5(2), CDC23(1), CDC27(1), CUL1(2), CUL2(1), CUL3(1), FBXW7(1), FZR1(1), ITCH(1), SMURF2(1) 29579833 14 13 14 5 2 5 3 1 3 0 0.461 1.000 1.000 500 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(1), ADH4(1), ADH7(2), AGPAT2(1), ALDH2(1), CEL(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), LCT(1), LPL(1), PPAP2C(1) 35473130 20 20 20 8 4 3 2 6 5 0 0.757 1.000 1.000 501 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(4), CASP6(1), GSN(1), MAP3K1(3), NUMA1(1), PRKDC(5), RASA1(2), RB1(2), SPTAN1(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(1), TRAF1(1) 50652047 25 23 25 9 2 4 4 6 9 0 0.733 1.000 1.000 502 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ALDH2(1), AOC3(1), AOX1(1), ASMT(1), CYP19A1(1), CYP1A2(1), CYP2A13(2), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), DDC(1), HAAO(1), HADHA(1), SDS(1), TDO2(2), WARS(1) 40618072 19 19 19 6 3 1 5 10 0 0 0.620 1.000 1.000 503 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(1), GTF2F2(1), POLR1A(1), POLR1B(2), POLR2A(1), POLR2B(1), POLR3B(1), POLR3D(1) 25845613 9 9 9 4 1 3 0 3 2 0 0.728 1.000 1.000 504 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(7), FSHR(1), MSH5(1), VDR(1) 25802320 10 10 10 9 1 2 2 3 2 0 0.995 1.000 1.000 505 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ABAT(1), ASL(1), CAD(1), DARS(1), GAD2(1), GOT1(1), GOT2(2), GPT(1), PC(3) 19172091 12 12 12 5 3 4 3 2 0 0 0.536 1.000 1.000 506 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(5), AKT2(1), AKT3(1), CBL(1), CDC42(1), CDKN2A(1), F2RL2(1), FLOT2(1), IGFBP1(1), IRS1(3), IRS2(2), LNPEP(2), PARD3(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PTEN(2), RPS6KA1(1), SHC1(1), SOS1(2), SOS2(2), YWHAE(1), YWHAG(1) 44005250 38 37 36 11 3 9 1 16 8 1 0.464 1.000 1.000 507 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 ABAT(1), ADSSL1(2), ASL(1), ASRGL1(1), CAD(1), DARS(1), DLAT(1), GAD2(1), GOT1(1), GOT2(2), GPT(1), PC(3), PDHA2(1) 27846490 17 17 17 8 5 4 4 2 2 0 0.755 1.000 1.000 508 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT10(1), GALNT12(1), GALNT14(1), GALNT2(1), GALNT7(1), GALNT8(1), GALNTL5(1) 23847328 8 8 8 5 2 0 1 4 1 0 0.944 1.000 1.000 509 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 GALT(2), GANAB(2), HK2(3), HK3(1), LCT(1), MGAM(1), PFKP(2) 23935646 12 12 12 6 4 4 2 1 1 0 0.636 1.000 1.000 510 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CANX(1), CD4(1), CD74(2), CTSS(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(2), HLA-DRA(1), HLA-E(1), HSP90AA1(3), HSPA5(1), KIR2DL3(1), KIR3DL1(1), KIR3DL2(1), RFX5(1), RFXAP(1) 34186983 20 20 20 8 6 5 2 4 3 0 0.620 1.000 1.000 511 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(4), BAD(1), CASP6(1), CD40LG(1), PTPN13(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(1), TRAF1(1) 31939949 13 13 13 7 3 2 1 4 3 0 0.927 1.000 1.000 512 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(1), ACACB(1), ACOT12(1), ACSS1(1), ACSS2(1), ALDH2(1), DLAT(1), HAGHL(1), LDHA(2), ME1(1), PC(3), PCK2(1), PDHA2(1), PKLR(1) 34518958 17 17 17 6 9 1 3 2 2 0 0.479 1.000 1.000 513 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), COL2A1(1), CPSF3(1), DHX16(1), DHX38(1), DHX8(3), DICER1(5), DNAJC8(1), GIPC1(1), NCBP1(1), PABPN1(1), POLR2A(1), PRPF3(1), PRPF4B(1), PRPF8(3), PTBP2(1), RBM17(1), RNMT(1), SF3A1(1), SF3A3(1), SF3B1(2), SPOP(1), SRRM1(1), U2AF1(1), U2AF2(1), XRN2(1) 78019857 35 32 35 7 3 9 6 11 6 0 0.181 1.000 1.000 514 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ALDH2(1), AOX1(1), BCAT1(1), HADHA(1), PCCA(1), SDS(1) 26531711 6 6 6 6 1 0 1 3 1 0 0.996 1.000 1.000 515 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IPMK(1), ISYNA1(2), OCRL(2), PI4KB(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIP4K2C(1), PIP5K1A(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1), PTEN(2) 54694509 23 22 23 8 4 0 4 7 7 1 0.767 1.000 1.000 516 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(1), ALDH2(1), DLAT(1), HAGHL(1), LDHA(2), ME1(1), PC(3), PDHA2(1), PKLR(1) 27260428 12 12 12 5 6 1 2 2 1 0 0.646 1.000 1.000 517 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(1), ADH4(1), ADH7(2), AGPAT2(1), AGPAT6(2), ALDH2(1), CEL(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), GK2(1), LCT(1), LPL(1), PPAP2C(1) 43191156 23 23 23 9 6 3 2 7 5 0 0.709 1.000 1.000 518 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY8(1), CACNA1A(2), CACNA1B(3), GNAS(3), GNB3(1), GRM4(2), PDE1A(1), PLCB2(1), TAS1R2(1), TAS1R3(1), TAS2R46(1), TAS2R7(1), TRPM5(1) 41830748 19 18 19 6 5 6 2 3 3 0 0.324 1.000 1.000 519 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(3), AXIN1(1), CTNNB1(2), TGFBR1(1), TGFBR2(1), TGFBR3(1) 26863620 9 9 9 8 0 2 3 3 1 0 0.985 1.000 1.000 520 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), ESR1(1), HNF4A(2), NR4A2(1), PPARA(1), RARA(1), THRA(1), VDR(1) 31126938 9 9 9 7 2 2 1 2 2 0 0.907 1.000 1.000 521 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(5), AKT2(1), AKT3(1), IFNAR2(1), IRF3(1), IRF5(2), JUN(1), LBP(1), MAP2K1(1), MAP2K6(1), MAP3K8(1), MAPK10(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), STAT1(1), TBK1(1), TLR2(1), TLR3(1), TLR4(1), TLR7(1), TLR8(1) 66231810 38 38 36 10 6 6 2 17 7 0 0.307 1.000 1.000 522 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(1), ACACB(1), ACSS1(1), ACSS2(1), ALDH2(1), HADHA(1), LDHA(2), MLYCD(1), PCCA(1) 29273847 11 11 11 5 3 1 1 5 1 0 0.820 1.000 1.000 523 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 GALT(2), HK2(3), HK3(1), HSD3B7(1), LCT(1), MGAM(1), PFKP(2), RDH14(1) 28406958 12 12 12 6 4 4 1 2 1 0 0.647 1.000 1.000 524 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(1), CANT1(1), CTPS2(1), DPYS(2), DTYMK(1), ITPA(1), NT5C1B(1), NT5E(1), POLD1(1), POLD3(1), POLE(1), POLE2(1), POLR1A(1), POLR1B(2), POLR2A(1), POLR2B(1), POLR3B(1), RRM1(1), TK1(2), TXNRD1(1) 59658423 23 23 22 6 2 2 4 8 7 0 0.592 1.000 1.000 525 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BFAR(2), CAD(1), FAIM2(1), MAP3K1(3), MAPK10(1), MAPK8IP2(1), MET(2), NFAT5(3), PTPN13(2), TP53(4) 53439405 20 20 20 6 3 1 2 7 7 0 0.507 1.000 1.000 526 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 CCR6(1), FPR1(1), FSHR(1), GALT(2), NTSR2(1), OPRL1(1), SSTR2(1), TACR3(3), TSHR(2) 38735763 13 13 13 5 0 6 3 4 0 0 0.493 1.000 1.000 527 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CREBBP(1), ERCC3(1), ESR1(1), HDAC5(1), NCOR2(1), POLR2A(1) 34204714 7 7 7 8 0 2 0 3 2 0 0.987 1.000 1.000 528 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ALDH2(1), AOX1(1), BCAT1(1), DBT(1), HADH(1), HADHA(1), PCCA(1) 31732300 8 8 8 5 1 1 2 3 1 0 0.961 1.000 1.000 529 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GNT1(1), B3GNT3(1), B3GNT5(1), FUT1(1), FUT3(2), PIGO(1), PIGS(1), PIGZ(2), ST6GALNAC6(1), ST8SIA1(1) 35723166 12 12 12 7 0 4 5 1 2 0 0.820 1.000 1.000 530 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), AMY2A(1), ENPP1(2), GANAB(2), GBE1(1), GYS2(1), HK2(3), HK3(1), MGAM(1), PYGB(1), UGT1A1(1), UGT1A3(2), UGT1A4(1) 41786643 19 19 19 8 3 4 5 4 3 0 0.615 1.000 1.000 531 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(1), ALG12(1), ALG13(2), ALG3(2), GANAB(2), MAN1C1(1), MGAT2(1), MGAT3(1), MGAT5B(2), RPN1(1), STT3B(1) 31272321 15 15 15 6 3 5 2 5 0 0 0.587 1.000 1.000 532 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CREBBP(1), JUN(1), LPL(1), ME1(1), MYC(1), NCOR2(1), PIK3CA(3), PIK3R1(2), PPARA(1), PRKAR2A(1), RB1(2), SP1(1), STAT5B(1) 46610489 17 17 17 9 3 2 4 4 4 0 0.868 1.000 1.000 533 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 CDC42(1), CLDN14(1), CLDN6(1), CTNNA3(1), CTNNB1(2), CTNND1(1), CYBA(1), EZR(1), ITGAL(4), ITGAM(2), ITGB1(2), ITGB2(1), JAM2(1), MLLT4(1), MMP2(1), OCLN(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLCG1(1), PTK2B(2), RAP1A(1), VAV2(1), VCAM1(2), VCL(2) 91625477 45 42 45 10 8 9 4 15 9 0 0.153 1.000 1.000 534 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(5), ANAPC1(1), ANAPC2(1), ANAPC5(2), ATM(7), ATR(3), CDC23(1), CDC27(1), CDC6(1), CDC7(1), CDKN1A(1), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(4), CREBBP(1), CUL1(2), E2F3(1), ESPL1(2), FZR1(1), MCM4(1), PRKDC(5), RB1(2), RBL1(1), RBL2(1), SMC1A(1), TP53(4), WEE1(1), YWHAE(1), YWHAG(1) 99856572 56 49 53 12 3 11 7 16 19 0 0.149 1.000 1.000 535 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH4(1), ADH7(2), ALDH2(1), ALDOB(1), DLAT(1), HK2(3), HK3(1), LDHA(2), PDHA2(1), PFKP(2), PKLR(1) 36053187 17 17 17 8 6 3 1 6 1 0 0.678 1.000 1.000 536 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH4(1), ADH7(2), ALDH2(1), ALDOB(1), DLAT(1), HK2(3), HK3(1), LDHA(2), PDHA2(1), PFKP(2), PKLR(1) 36053187 17 17 17 8 6 3 1 6 1 0 0.678 1.000 1.000 537 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(1), ADH1B(1), ADH4(1), ADH7(2), ALDH2(1), ALDOB(1), DLAT(1), HK2(3), HK3(1), LDHA(2), PDHA2(1), PFKP(2), PGAM4(1), PKLR(1) 42930212 20 20 20 9 7 3 1 7 2 0 0.623 1.000 1.000 538 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALML6(1), CDS2(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), INPP5D(1), ITPR1(2), ITPR2(6), OCRL(2), PI4KB(1), PIK3C2A(1), PIK3C2G(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PIP4K2C(1), PIP5K1A(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1), PTEN(2) 91542412 50 45 50 12 11 7 5 13 13 1 0.178 1.000 1.000 539 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(2), RPL12(1), RPL13A(1), RPL18A(1), RPL4(1), RPL9(2), RPS2(1), RPS4X(1), RPS6KA1(1), RPS6KB2(1), UBC(1) 38508163 13 12 13 8 3 5 2 2 1 0 0.917 1.000 1.000 540 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ANGPTL4(1), AQP7(1), CPT1A(3), CPT1C(1), CYP4A11(2), GK2(1), LPL(1), ME1(1), PCK2(1), PLTP(1), PPARA(1), SLC27A4(2), UBC(1) 48320230 17 17 16 6 6 3 3 4 1 0 0.462 1.000 1.000 541 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(5), AKT2(1), AKT3(1), CBL(1), CNTF(1), CREBBP(1), CSF2RA(1), CSF2RB(3), CSF3R(1), GHR(1), IFNAR2(1), IFNGR1(1), IL11(1), IL11RA(1), IL12RB2(1), IL22(1), IL23R(1), IL2RA(1), IL2RG(1), IL7R(3), JAK1(1), JAK2(1), LEPR(1), MYC(1), OSMR(1), PIAS2(1), PIAS3(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), SOS1(2), SOS2(2), SPRED2(1), STAM2(1), STAT1(1), STAT2(1), STAT4(1), STAT5B(1), STAT6(1), TPO(1), TYK2(1) 107140863 62 58 60 16 13 12 6 20 11 0 0.160 1.000 1.000 542 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(2), CD38(2), CD3D(1), CD4(1), CD44(1), CD5(2), CR1(1), CSF2RA(1), CSF3R(1), FCER2(1), FLT3LG(1), HLA-DRA(1), IL11(1), IL11RA(1), IL1R1(2), IL2RA(1), IL7R(3), ITGA3(2), ITGAM(2), ITGB3(1), KIT(4), THPO(2), TPO(1) 59986885 35 32 35 11 12 9 2 10 2 0 0.240 1.000 1.000 543 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADM(1), ARRB1(1), ARRB2(1), ATF5(2), ATP2A2(2), CACNB3(1), CAMK2A(1), CAMK2B(1), CNN2(1), CORIN(1), CRH(1), CRHR1(1), DGKZ(2), GBA2(2), GJA1(1), GNB3(1), GNG5(1), GNGT1(1), GUCA2B(1), GUCY1A3(1), IGFBP1(1), ITPR1(2), ITPR2(6), JUN(1), MIB1(1), NOS1(1), PDE4B(1), PDE4D(1), PLCB3(1), PLCD1(1), PLCG1(1), PRKAR2A(1), PRKD1(3), RGS6(1), RGS9(1), RLN1(1), RYR1(8), RYR2(4), RYR3(1), SLC8A1(3), SP1(1), TNXB(3), USP5(1) 127275128 76 67 74 19 14 16 9 24 13 0 0.0719 1.000 1.000 544 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(1), ABCA10(1), ABCA12(2), ABCA13(1), ABCA2(2), ABCA3(3), ABCA4(1), ABCA5(3), ABCA6(1), ABCA9(1), ABCB11(4), ABCB4(1), ABCB5(1), ABCB6(1), ABCB7(2), ABCC10(4), ABCC2(2), ABCC3(1), ABCC4(1), ABCC5(2), ABCC6(2), ABCC9(1), ABCD1(4), ABCD4(1), ABCG8(2), CFTR(2) 86587267 47 44 47 14 11 9 5 11 11 0 0.237 1.000 1.000 545 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(5), AKT3(1), CAPN6(1), CAPN9(1), CDC42(1), FYN(1), GIT2(1), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), ITGAD(2), ITGAL(4), ITGAM(2), ITGAV(1), ITGAX(1), ITGB1(2), ITGB2(1), ITGB3(1), ITGB8(1), MAP2K1(1), MAP2K6(1), MAPK10(1), MAPK4(1), PAK3(2), RAPGEF1(2), SDCCAG8(1), SHC1(1), SOS1(2), SRC(2), TLN1(1), TNS1(3), VAV2(1), VCL(2), ZYX(1) 98579801 57 53 55 17 12 14 3 19 9 0 0.330 1.000 1.000 546 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(1), ADRA1A(1), ADRA2B(1), ADRB1(1), CALCR(1), CHRM4(1), CHRM5(1), CNR1(2), CNR2(2), CRHR1(1), CYSLTR2(1), DRD4(2), DRD5(3), F2RL2(1), FPR1(1), FSHR(1), GABRA2(2), GABRA3(1), GABRA6(1), GABRB3(1), GABRD(1), GABRE(1), GABRQ(2), GABRR1(1), GABRR2(1), GHR(1), GLP2R(2), GLRA3(1), GPR156(1), GPR35(1), GRIA1(1), GRIA2(2), GRIA4(1), GRID1(1), GRID2(1), GRIK1(2), GRIK2(1), GRIK3(1), GRIN2A(2), GRIN2B(4), GRIN2D(3), GRIN3A(1), GRM1(3), GRM2(1), GRM4(2), GRM6(3), HCRTR1(1), HRH1(1), HRH2(1), HTR2B(1), HTR5A(1), LEPR(1), LTB4R(2), LTB4R2(1), MCHR1(1), MTNR1B(1), NPBWR1(1), NPBWR2(1), NPFFR2(1), NTSR2(1), OPRL1(1), PARD3(1), PRSS1(1), PTGER3(1), PTGER4(1), PTH2R(1), RXFP1(1), RXFP2(1), SSTR2(1), TAAR5(1), TACR3(3), THRA(1), TSHR(2) 163637628 98 83 98 26 19 23 10 38 8 0 0.0484 1.000 1.000 547 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(4), DOT1L(1), EED(2), EHMT2(1), EZH1(2), FBXO11(2), HCFC1(1), HSF4(1), JMJD4(1), KDM6A(1), MEN1(3), NSD1(4), PAXIP1(1), PRDM9(5), PRMT8(3), SATB1(1), SETD1A(3), SETD2(1), SETDB1(1), SUV420H1(1), SUV420H2(1), WHSC1L1(2) 87758290 42 40 41 12 6 7 10 12 7 0 0.364 1.000 1.000 548 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 AKT1(5), CDKL2(1), CDS2(1), CLK1(1), CSNK2A1(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), OCRL(2), PIK3C2A(1), PIK3C2G(1), PIK3CA(3), PIK3CB(1), PIK3CG(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1), PRKAR2A(1), PRKD1(3), PRKG1(1), RPS6KA1(1), RPS6KA4(1), TGFBR1(1) 83003966 42 41 40 13 4 8 7 12 11 0 0.475 1.000 1.000 549 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADRA1A(1), ADRB1(1), ATP2A2(2), ATP2B3(1), ATP2B4(2), CACNA1A(2), CACNA1B(3), CACNA1C(2), CACNA1D(4), CACNA1E(5), CACNA1G(3), CACNA1H(1), CACNA1S(1), CALML6(1), CAMK2A(1), CAMK2B(1), CD38(2), CHRM5(1), CYSLTR2(1), ERBB2(1), ERBB3(3), ERBB4(3), GNAL(2), GNAS(3), GRIN2A(2), GRIN2D(3), GRM1(3), HRH1(1), HRH2(1), HTR2B(1), HTR5A(1), ITPR1(2), ITPR2(6), LTB4R2(1), MYLK(4), NOS1(1), PDE1A(1), PDGFRB(1), PHKA2(3), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1), PPID(1), PTGER3(1), PTK2B(2), RYR1(8), RYR2(4), RYR3(1), SLC8A1(3), SLC8A3(2), SPHK2(1), TACR3(3), VDAC1(1), VDAC3(1) 198343139 118 102 117 36 24 27 14 37 16 0 0.129 1.000 1.000 550 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 CD44(1), COL11A1(1), COL11A2(2), COL1A1(1), COL2A1(1), COL3A1(2), COL4A1(3), COL4A2(2), COL4A4(2), COL4A6(1), COL5A1(4), COL5A3(8), COL6A2(3), COL6A3(2), COL6A6(3), FN1(3), FNDC3A(2), HMMR(1), HSPG2(1), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), ITGAV(1), ITGB1(2), ITGB3(1), ITGB8(1), LAMA2(1), LAMA3(3), LAMA4(4), LAMA5(2), LAMB1(1), LAMB2(1), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), RELN(2), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SV2C(1), THBS1(1), THBS2(2), THBS3(1), THBS4(1), TNC(1), TNN(1), TNR(3), TNXB(3), VTN(1), VWF(1) 165107238 97 88 97 36 17 21 8 35 16 0 0.645 1.000 1.000 551 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(1), COL11A1(1), COL11A2(2), COL1A1(1), COL2A1(1), COL3A1(2), COL4A1(3), COL4A2(2), COL4A4(2), COL4A6(1), COL5A1(4), COL5A3(8), COL6A2(3), COL6A3(2), COL6A6(3), DSG3(1), DSG4(1), FN1(3), GJA1(1), GJA3(2), GJA8(1), GJD2(1), KRT18(1), KRT20(1), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT33B(1), KRT35(2), KRT6C(1), KRT85(3), KRT9(1), LAMA2(1), LAMA3(3), LAMA4(4), LAMA5(2), LAMB1(1), LAMB2(1), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), NES(1), RELN(2), THBS1(1), THBS2(2), THBS3(1), THBS4(1), TNC(1), TNN(1), TNR(3), TNXB(3), VIM(1), VTN(1), VWF(1) 183550705 98 86 98 39 18 23 7 30 20 0 0.784 1.000 1.000 552 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADRA1A(1), ADRB1(1), ARRB1(1), ARRB2(1), ATP1A4(1), ATP2A2(2), ATP2B3(1), CACNA1A(2), CACNA1B(3), CACNA1C(2), CACNA1D(4), CACNA1E(5), CACNA1S(1), CACNB3(1), CAMK2A(1), CAMK2B(1), CHRM4(1), CHRM5(1), GJA1(1), GNB3(1), GNG5(1), GNGT1(1), ITPR1(2), ITPR2(6), MIB1(1), PLCB3(1), PRKAR2A(1), PRKD1(3), RGS6(1), RGS9(1), RYR1(8), RYR2(4), RYR3(1), SLC8A1(3), SLC8A3(2), USP5(1) 137841121 75 72 74 26 12 20 10 20 13 0 0.318 1.000 1.000 553 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR2A(1), ACVR2B(1), AMHR2(1), CCL23(1), CCL24(1), CCR6(1), CD40LG(1), CNTF(1), CSF2RA(1), CSF2RB(3), CSF3R(1), CXCL13(1), CXCL5(1), FLT3LG(1), FLT4(1), GHR(1), IFNAR2(1), IFNGR1(1), IL11(1), IL11RA(1), IL12RB2(1), IL17RB(1), IL18RAP(1), IL1R1(2), IL22(1), IL23R(1), IL2RA(1), IL2RG(1), IL7R(3), INHBA(2), INHBC(1), INHBE(1), KDR(2), KIT(4), LEPR(1), MET(2), OSMR(1), PDGFRB(1), PF4V1(1), RELT(1), TGFBR1(1), TGFBR2(1), TNFRSF14(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF9(1), TNFSF15(1), TNFSF4(1), TNFSF9(1), TPO(1), VEGFA(1) 130792366 62 56 62 22 15 11 13 14 9 0 0.412 1.000 1.000 554 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(3), APC2(1), AXIN1(1), CAMK2A(1), CAMK2B(1), CREBBP(1), CSNK2A1(1), CTBP1(1), CTBP2(1), CTNNB1(2), CUL1(2), DAAM1(2), DKK4(1), DVL2(2), DVL3(1), FZD10(1), FZD3(1), FZD8(2), JUN(1), LEF1(1), LRP5(2), MAPK10(1), MMP7(1), MYC(1), NFAT5(3), NFATC1(1), NFATC4(3), NKD1(1), NKD2(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PPP2R1A(3), PPP2R1B(1), PPP2R2B(1), PRICKLE1(1), SENP2(1), TCF7L1(4), TCF7L2(1), TP53(4), VANGL1(2), WNT11(1), WNT4(1), WNT5B(1) 118818054 66 56 65 21 12 8 9 18 19 0 0.405 1.000 1.000 555 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(1), CD28(1), CD4(1), CD40LG(1), CDH4(1), CLDN14(1), CLDN6(1), CNTNAP1(1), GLG1(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(2), HLA-DRA(1), HLA-E(1), ITGA8(1), ITGA9(1), ITGAL(4), ITGAM(2), ITGAV(1), ITGB1(2), ITGB2(1), ITGB8(1), JAM2(1), MADCAM1(1), MPZ(1), NCAM2(1), NEO1(1), NRXN1(4), NRXN2(1), NRXN3(2), OCLN(1), PDCD1(1), PDCD1LG2(1), PVRL1(3), SDC1(1), SDC2(1), SDC3(1), SDC4(1), VCAM1(2), VCAN(1) 108803411 54 52 54 25 13 9 9 14 9 0 0.838 1.000 1.000 556 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADSSL1(2), AK7(1), AMPD1(1), AMPD2(2), AMPD3(1), CANT1(1), ENPP1(2), GMPS(1), GUCY1A3(1), GUK1(1), IMPDH2(1), ITPA(1), NPR1(2), NT5C1B(1), NT5E(1), PAPSS1(2), PDE1A(1), PDE2A(1), PDE4B(1), PDE4D(1), PDE5A(2), PDE7B(1), PFAS(1), PKLR(1), POLD1(1), POLD3(1), POLE(1), POLE2(1), POLR1A(1), POLR1B(2), POLR2A(1), POLR2B(1), POLR3B(1), PPAT(1), PRPS1(2), RRM1(1), XDH(1) 120242059 51 48 51 22 12 5 5 19 10 0 0.921 1.000 1.000 557 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(2), AMY2A(1), ASCC3(1), DDX18(1), DDX23(3), DDX4(2), DDX47(1), DDX51(1), DDX52(1), ENPP1(2), ENTPD7(1), EP400(4), ERCC3(1), GBE1(1), GYS2(1), HK2(3), HK3(1), MGAM(1), MOV10L1(1), NUDT8(1), PYGB(1), SETX(2), SMARCA5(1), UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2) 90936034 42 40 40 20 4 7 10 12 9 0 0.875 1.000 1.000 558 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY3(1), ADCY7(1), ADCY8(1), AMPD1(1), AMPD2(2), AMPD3(1), CANT1(1), ENPP1(2), GMPS(1), GUCY1A3(1), GUK1(1), IMPDH2(1), ITPA(1), NPR1(2), NT5E(1), PAPSS1(2), PDE1A(1), PDE4B(1), PDE4D(1), PDE5A(2), PDE7B(1), PFAS(1), PKLR(1), POLB(1), POLD1(1), POLE(1), POLL(1), POLQ(2), POLR1B(2), POLR2A(1), POLR2B(1), PPAT(1), PRPS1(2), RRM1(1) 94454273 42 40 42 16 12 6 4 14 6 0 0.634 1.000 1.000 559 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), DMD(2), MYBPC2(2), MYH3(2), MYH6(3), MYH7(3), MYH8(1), MYOM1(2), NEB(1), TCAP(1), TNNT3(1), TPM3(1), TTN(18), VIM(1) 99727093 39 37 38 14 4 11 6 11 7 0 0.541 1.000 1.000 560 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADRA1A(1), ADRB1(1), CCR6(1), CHRM4(1), CHRM5(1), CNR1(2), CNR2(2), DRD4(2), DRD5(3), F2RL2(1), FPR1(1), FSHR(1), GALT(2), GPR173(1), GPR35(1), GPR4(1), GPR87(1), HCRTR1(1), HRH1(1), HRH2(1), HTR2B(1), HTR5A(1), LTB4R(2), MTNR1B(1), NTSR2(1), OPRL1(1), OR12D3(1), OR5V1(1), OR7A5(1), PTGER4(1), RGR(1), SSTR2(1) 89878553 39 36 39 15 5 11 4 17 2 0 0.441 1.000 1.000 561 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG10B(1), ALG12(1), ALG13(2), ALG3(2), B3GNT1(1), C1GALT1(1), CHSY1(1), EXT1(1), EXT2(2), GALNT10(1), GALNT12(1), GALNT14(1), GALNT2(1), GALNT7(1), GALNT8(1), GALNTL5(1), GANAB(2), HS3ST2(1), MAN1C1(1), MGAT2(1), MGAT3(1), MGAT5B(2), NDST2(1), NDST3(1), NDST4(1), RPN1(1), STT3B(1), XYLT2(1) 81456471 33 33 33 18 6 6 5 13 3 0 0.927 1.000 1.000 562 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(7), CDKN1A(1), CDKN2A(1), CDKN2C(1), CREB3L3(3), E2F3(1), GBA2(2), MCM4(1), MYC(1), MYT1(1), POLE(1), POLE2(1), RB1(2), RBL1(1), TNXB(3), TP53(4), WEE1(1) 56851810 32 31 32 12 3 6 4 11 8 0 0.692 1.000 1.000 563 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(1), AKT1(5), AKT2(1), AKT3(1), CAMKK2(1), CPT1A(3), CPT1C(1), IRS1(3), IRS2(2), JAK1(1), JAK2(1), LEPR(1), MAPK10(1), PCK2(1), PPARA(1), PPARGC1A(3), PRKAG2(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(1), TYK2(1) 61197982 32 29 30 13 6 7 4 12 3 0 0.632 1.000 1.000 564 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(1), C1QA(1), C1R(1), C2(2), C3(1), C4BPA(1), C5(1), C6(1), C7(2), CD46(1), CR1(1), F10(2), F7(1), F8(3), F9(1), FGA(1), PLG(1), PROC(1), PROS1(2), SERPINA1(1), VWF(1) 66546903 27 25 27 12 7 1 1 11 7 0 0.859 1.000 1.000 565 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(1), ASCC3(1), DDX18(1), DDX23(3), DDX4(2), DDX47(1), DDX51(1), DDX52(1), ENTPD7(1), EP400(4), ERCC3(1), MOV10L1(1), NUDT8(1), SETX(2), SMARCA5(1), SPR(1) 46284707 24 24 22 12 2 3 6 7 6 0 0.894 1.000 1.000 566 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 CELSR1(3), CELSR2(1), CELSR3(1), DRD4(2), EMR2(1), FSHR(1), GPR116(1), GPR133(1), GRM1(3), LPHN2(1), LPHN3(2), LTB4R2(1), SSTR2(1), TAAR5(1), TSHR(2), VN1R1(2) 49283955 24 23 24 12 2 4 5 11 2 0 0.856 1.000 1.000 567 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(1), CTBP1(1), CTBP2(1), DLL1(1), DTX1(2), DVL2(2), DVL3(1), MAML1(1), MAML3(1), NCOR2(1), NOTCH2(1), NOTCH3(1), NOTCH4(4), NUMBL(1), RBPJ(1) 51093154 20 20 20 10 3 5 2 6 4 0 0.893 1.000 1.000 568 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP6(2), CSNK1G3(1), DHH(1), GAS1(1), GLI2(3), GLI3(1), LRP2(2), PTCH1(2), PTCH2(1), SUFU(1), WNT11(1), WNT4(1), WNT5B(1), ZIC2(2) 44899595 20 19 20 10 8 2 3 3 4 0 0.736 1.000 1.000 569 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), MCM10(1), MCM4(1), POLD1(1), POLD3(1), POLE(1), POLE2(1), UBC(1) 37351101 9 9 9 12 2 0 1 4 2 0 1.000 1.000 1.000 570 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ALDH2(1), ALDH5A1(1), GAD2(1), HADHA(1), PDHA2(1), SDS(1) 19043630 8 8 8 5 2 3 0 3 0 0 0.847 1.000 1.000 571 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), ETV5(1), IL12RB2(1), JAK2(1), JUN(1), MAP2K6(1), STAT4(1), TYK2(1) 13813049 8 8 8 5 5 0 0 3 0 0 0.862 1.000 1.000 572 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(1), ALDH2(1), ATP6V0C(1), DOT1L(1), EHMT2(1), HADHA(1), SDS(1), TMLHE(1) 27277542 8 8 8 5 1 1 0 6 0 0 0.924 1.000 1.000 573 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 DEGS1(1), DEGS2(1), LCT(1), PPAP2C(1), SMPD2(1), SMPD4(1), SPHK2(1) 26439710 7 7 7 6 2 1 1 3 0 0 0.976 1.000 1.000 574 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2F2(1), GTF2IRD1(1), TAF1L(2), TAF2(2), TAF6L(1) 26556293 7 7 7 6 3 2 1 1 0 0 0.943 1.000 1.000 575 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CD4(1), IL12RB2(1), JAK2(1), STAT4(1), TYK2(1) 10898293 6 6 6 5 4 0 0 2 0 0 0.931 1.000 1.000 576 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 F2RL2(1), JUN(1), PLD2(1), RASAL1(1), SRC(2) 20231485 6 6 6 5 3 1 0 2 0 0 0.916 1.000 1.000 577 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(1), CAPNS2(1), NFATC1(1), SYT1(1) 17991013 4 4 4 3 2 1 1 0 0 0 0.894 1.000 1.000 578 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CD28(1), CD4(1), IFNGR1(1), IL12RB2(1) 14812756 4 4 4 3 2 0 1 1 0 0 0.888 1.000 1.000 579 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(1), CD44(1), TNFRSF1A(1), TNFRSF1B(1) 9647564 4 4 4 3 1 2 0 1 0 0 0.874 1.000 1.000 580 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 LCT(1), PPAP2C(1), SMPD2(1) 17885580 3 3 3 4 1 0 1 1 0 0 0.991 1.000 1.000 581 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH2(1), HADHA(1), SDS(1) 8971898 3 3 3 3 1 0 0 2 0 0 0.958 1.000 1.000 582 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 JAK1(1), JAK2(1), TYK2(1) 7739156 3 3 3 3 1 1 0 1 0 0 0.919 1.000 1.000 583 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 JAK1(1), JAK2(1), TYK2(1) 7739156 3 3 3 3 1 1 0 1 0 0 0.919 1.000 1.000 584 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL16(2) 7319827 2 2 2 4 0 1 1 0 0 0 0.972 1.000 1.000 585 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST6GALNAC2(1), ST8SIA1(1) 4170498 2 2 2 3 0 0 2 0 0 0 0.981 1.000 1.000 586 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR39(1) 7272122 2 2 2 3 1 1 0 0 0 0 0.949 1.000 1.000 587 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 FASN(1), HADHA(1) 10532116 2 2 2 2 0 0 0 2 0 0 0.941 1.000 1.000 588 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 JAK1(1), STAT1(1) 8988073 2 2 2 2 0 1 0 1 0 0 0.877 1.000 1.000 589 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), RETN(1) 4278226 2 2 2 2 0 2 0 0 0 0 0.828 1.000 1.000 590 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH2(1) 5896802 1 1 1 2 0 0 0 1 0 0 0.978 1.000 1.000 591 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH2(1) 5896802 1 1 1 2 0 0 0 1 0 0 0.978 1.000 1.000 592 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(1) 9871113 1 1 1 4 1 0 0 0 0 0 0.995 1.000 1.000 593 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1) 9212952 1 1 1 3 0 0 1 0 0 0 0.996 1.000 1.000 594 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 MEF2B(1) 5589475 1 1 1 2 1 0 0 0 0 0 0.978 1.000 1.000 595 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 SYT1(1) 15956328 1 1 1 3 0 1 0 0 0 0 0.986 1.000 1.000 596 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(1) 6207637 1 1 1 2 0 1 0 0 0 0 0.984 1.000 1.000 597 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 HSD17B1(1), HSD17B3(1) 5962250 2 1 2 2 0 0 1 1 0 0 0.953 1.000 1.000 598 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 4086469 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 599 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 2398777 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 600 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 4020886 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 601 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 1216252 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 602 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 3364954 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 603 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 534927 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 604 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 1340702 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 605 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 375841 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 1557829 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 607 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 4731453 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 2881161 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 609 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 2188714 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 610 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 4459118 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 1262882 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 6360101 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 2866274 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 2491664 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 10701879 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 7765075 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000