This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.
Testing the association between mutation status of 8 genes and 10 molecular subtypes across 120 patients, 24 significant findings detected with P value < 0.05 and Q value < 0.25.
-
GTF2I mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
-
HRAS mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
-
TP53 mutation correlated to 'MRNASEQ_CHIERARCHICAL' and 'MIRSEQ_CHIERARCHICAL'.
-
PLEKHG4B mutation correlated to 'CN_CNMF'.
-
UNC93B1 mutation correlated to 'CN_CNMF'.
Clinical Features |
CN CNMF |
METHLYATION CNMF |
RPPA CNMF |
RPPA CHIERARCHICAL |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRSEQ MATURE CNMF |
MIRSEQ MATURE CHIERARCHICAL |
||
nMutated (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
GTF2I | 49 (41%) | 71 |
1e-05 (6.67e-05) |
1e-05 (6.67e-05) |
3e-05 (0.000171) |
1e-05 (6.67e-05) |
1e-05 (6.67e-05) |
1e-05 (6.67e-05) |
1e-05 (6.67e-05) |
1e-05 (6.67e-05) |
1e-05 (6.67e-05) |
1e-05 (6.67e-05) |
HRAS | 10 (8%) | 110 |
0.00094 (0.0047) |
2e-05 (0.000123) |
0.0273 (0.101) |
5e-05 (0.000267) |
1e-05 (6.67e-05) |
1e-05 (6.67e-05) |
0.0409 (0.142) |
1e-05 (6.67e-05) |
0.017 (0.0682) |
0.00257 (0.0121) |
TP53 | 4 (3%) | 116 |
0.467 (0.748) |
0.221 (0.431) |
1 (1.00) |
0.11 (0.283) |
0.0517 (0.165) |
0.0279 (0.101) |
0.446 (0.729) |
0.00854 (0.038) |
0.0767 (0.212) |
0.784 (1.00) |
PLEKHG4B | 3 (2%) | 117 |
0.0154 (0.0647) |
0.12 (0.301) |
0.503 (0.773) |
0.197 (0.395) |
0.648 (0.899) |
0.294 (0.547) |
0.609 (0.899) |
0.79 (1.00) |
||
UNC93B1 | 5 (4%) | 115 |
0.0463 (0.154) |
0.178 (0.385) |
0.676 (0.917) |
0.185 (0.39) |
0.149 (0.351) |
0.155 (0.355) |
0.084 (0.224) |
0.145 (0.351) |
0.0762 (0.212) |
0.0557 (0.171) |
CAPNS1 | 3 (2%) | 117 |
0.652 (0.899) |
0.946 (1.00) |
0.648 (0.899) |
0.844 (1.00) |
1 (1.00) |
0.935 (1.00) |
0.446 (0.729) |
1 (1.00) |
||
ATRN | 3 (2%) | 117 |
0.902 (1.00) |
0.434 (0.729) |
0.365 (0.648) |
0.0633 (0.187) |
0.338 (0.615) |
0.161 (0.359) |
0.251 (0.478) |
0.493 (0.773) |
||
NRAS | 3 (2%) | 117 |
0.903 (1.00) |
0.397 (0.691) |
1 (1.00) |
0.197 (0.395) |
0.645 (0.899) |
0.721 (0.961) |
0.609 (0.899) |
0.892 (1.00) |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 35 | 27 | 19 | 29 | 10 |
GTF2I MUTATED | 4 | 22 | 8 | 11 | 4 |
GTF2I WILD-TYPE | 31 | 5 | 11 | 18 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 34 | 23 | 19 | 10 | 18 | 8 | 2 | 6 |
GTF2I MUTATED | 2 | 22 | 0 | 0 | 17 | 5 | 1 | 2 |
GTF2I WILD-TYPE | 32 | 1 | 19 | 10 | 1 | 3 | 1 | 4 |
P value = 3e-05 (Fisher's exact test), Q value = 0.00017
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 31 | 25 | 31 |
GTF2I MUTATED | 10 | 21 | 8 |
GTF2I WILD-TYPE | 21 | 4 | 23 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 16 | 23 | 28 | 20 |
GTF2I MUTATED | 8 | 22 | 9 | 0 |
GTF2I WILD-TYPE | 8 | 1 | 19 | 20 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 30 | 30 | 14 |
GTF2I MUTATED | 0 | 16 | 28 | 2 |
GTF2I WILD-TYPE | 42 | 14 | 2 | 12 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 42 | 20 | 10 |
GTF2I MUTATED | 0 | 27 | 19 | 0 |
GTF2I WILD-TYPE | 44 | 15 | 1 | 10 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 54 | 61 | 5 |
GTF2I MUTATED | 3 | 46 | 0 |
GTF2I WILD-TYPE | 51 | 15 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 26 | 18 | 26 | 7 | 16 | 27 |
GTF2I MUTATED | 1 | 16 | 2 | 0 | 15 | 15 |
GTF2I WILD-TYPE | 25 | 2 | 24 | 7 | 1 | 12 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 25 | 51 | 43 | 1 |
GTF2I MUTATED | 0 | 45 | 4 | 0 |
GTF2I WILD-TYPE | 25 | 6 | 39 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 26 | 33 | 33 | 28 |
GTF2I MUTATED | 1 | 30 | 2 | 16 |
GTF2I WILD-TYPE | 25 | 3 | 31 | 12 |
P value = 0.00094 (Fisher's exact test), Q value = 0.0047
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 35 | 27 | 19 | 29 | 10 |
HRAS MUTATED | 0 | 7 | 2 | 0 | 1 |
HRAS WILD-TYPE | 35 | 20 | 17 | 29 | 9 |
P value = 2e-05 (Fisher's exact test), Q value = 0.00012
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 34 | 23 | 19 | 10 | 18 | 8 | 2 | 6 |
HRAS MUTATED | 0 | 10 | 0 | 0 | 0 | 0 | 0 | 0 |
HRAS WILD-TYPE | 34 | 13 | 19 | 10 | 18 | 8 | 2 | 6 |
P value = 0.0273 (Fisher's exact test), Q value = 0.1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 31 | 25 | 31 |
HRAS MUTATED | 3 | 5 | 0 |
HRAS WILD-TYPE | 28 | 20 | 31 |
P value = 5e-05 (Fisher's exact test), Q value = 0.00027
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 16 | 23 | 28 | 20 |
HRAS MUTATED | 0 | 8 | 0 | 0 |
HRAS WILD-TYPE | 16 | 15 | 28 | 20 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 30 | 30 | 14 |
HRAS MUTATED | 0 | 0 | 10 | 0 |
HRAS WILD-TYPE | 42 | 30 | 20 | 14 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 42 | 20 | 10 |
HRAS MUTATED | 0 | 0 | 10 | 0 |
HRAS WILD-TYPE | 44 | 42 | 10 | 10 |
P value = 0.0409 (Fisher's exact test), Q value = 0.14
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 54 | 61 | 5 |
HRAS MUTATED | 1 | 9 | 0 |
HRAS WILD-TYPE | 53 | 52 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 6.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 26 | 18 | 26 | 7 | 16 | 27 |
HRAS MUTATED | 0 | 0 | 1 | 0 | 8 | 1 |
HRAS WILD-TYPE | 26 | 18 | 25 | 7 | 8 | 26 |
P value = 0.017 (Fisher's exact test), Q value = 0.068
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 25 | 51 | 43 | 1 |
HRAS MUTATED | 0 | 9 | 1 | 0 |
HRAS WILD-TYPE | 25 | 42 | 42 | 1 |
P value = 0.00257 (Fisher's exact test), Q value = 0.012
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 26 | 33 | 33 | 28 |
HRAS MUTATED | 0 | 8 | 1 | 1 |
HRAS WILD-TYPE | 26 | 25 | 32 | 27 |
P value = 0.652 (Fisher's exact test), Q value = 0.9
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 35 | 27 | 19 | 29 | 10 |
CAPNS1 MUTATED | 0 | 1 | 1 | 1 | 0 |
CAPNS1 WILD-TYPE | 35 | 26 | 18 | 28 | 10 |
P value = 0.946 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 34 | 23 | 19 | 10 | 18 | 8 | 2 | 6 |
CAPNS1 MUTATED | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
CAPNS1 WILD-TYPE | 33 | 22 | 19 | 10 | 17 | 8 | 2 | 6 |
P value = 0.648 (Fisher's exact test), Q value = 0.9
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 30 | 30 | 14 |
CAPNS1 MUTATED | 1 | 2 | 0 | 0 |
CAPNS1 WILD-TYPE | 41 | 28 | 30 | 14 |
P value = 0.844 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 42 | 20 | 10 |
CAPNS1 MUTATED | 1 | 2 | 0 | 0 |
CAPNS1 WILD-TYPE | 43 | 40 | 20 | 10 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 54 | 61 | 5 |
CAPNS1 MUTATED | 1 | 2 | 0 |
CAPNS1 WILD-TYPE | 53 | 59 | 5 |
P value = 0.935 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 26 | 18 | 26 | 7 | 16 | 27 |
CAPNS1 MUTATED | 0 | 1 | 1 | 0 | 0 | 1 |
CAPNS1 WILD-TYPE | 26 | 17 | 25 | 7 | 16 | 26 |
P value = 0.446 (Fisher's exact test), Q value = 0.73
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 25 | 51 | 43 | 1 |
CAPNS1 MUTATED | 1 | 2 | 0 | 0 |
CAPNS1 WILD-TYPE | 24 | 49 | 43 | 1 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 26 | 33 | 33 | 28 |
CAPNS1 MUTATED | 0 | 1 | 1 | 1 |
CAPNS1 WILD-TYPE | 26 | 32 | 32 | 27 |
P value = 0.467 (Fisher's exact test), Q value = 0.75
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 35 | 27 | 19 | 29 | 10 |
TP53 MUTATED | 1 | 1 | 1 | 0 | 1 |
TP53 WILD-TYPE | 34 | 26 | 18 | 29 | 9 |
P value = 0.221 (Fisher's exact test), Q value = 0.43
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 34 | 23 | 19 | 10 | 18 | 8 | 2 | 6 |
TP53 MUTATED | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 0 |
TP53 WILD-TYPE | 33 | 23 | 18 | 8 | 18 | 8 | 2 | 6 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 31 | 25 | 31 |
TP53 MUTATED | 1 | 1 | 1 |
TP53 WILD-TYPE | 30 | 24 | 30 |
P value = 0.11 (Fisher's exact test), Q value = 0.28
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 16 | 23 | 28 | 20 |
TP53 MUTATED | 1 | 0 | 0 | 2 |
TP53 WILD-TYPE | 15 | 23 | 28 | 18 |
P value = 0.0517 (Fisher's exact test), Q value = 0.17
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 30 | 30 | 14 |
TP53 MUTATED | 2 | 0 | 0 | 2 |
TP53 WILD-TYPE | 40 | 30 | 30 | 12 |
P value = 0.0279 (Fisher's exact test), Q value = 0.1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 42 | 20 | 10 |
TP53 MUTATED | 2 | 0 | 0 | 2 |
TP53 WILD-TYPE | 42 | 42 | 20 | 8 |
P value = 0.446 (Fisher's exact test), Q value = 0.73
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 54 | 61 | 5 |
TP53 MUTATED | 3 | 1 | 0 |
TP53 WILD-TYPE | 51 | 60 | 5 |
P value = 0.00854 (Fisher's exact test), Q value = 0.038
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 26 | 18 | 26 | 7 | 16 | 27 |
TP53 MUTATED | 1 | 0 | 0 | 2 | 1 | 0 |
TP53 WILD-TYPE | 25 | 18 | 26 | 5 | 15 | 27 |
P value = 0.0767 (Fisher's exact test), Q value = 0.21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 25 | 51 | 43 | 1 |
TP53 MUTATED | 0 | 0 | 4 | 0 |
TP53 WILD-TYPE | 25 | 51 | 39 | 1 |
P value = 0.784 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 26 | 33 | 33 | 28 |
TP53 MUTATED | 1 | 1 | 2 | 0 |
TP53 WILD-TYPE | 25 | 32 | 31 | 28 |
P value = 0.902 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 35 | 27 | 19 | 29 | 10 |
ATRN MUTATED | 1 | 0 | 1 | 1 | 0 |
ATRN WILD-TYPE | 34 | 27 | 18 | 28 | 10 |
P value = 0.434 (Fisher's exact test), Q value = 0.73
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 34 | 23 | 19 | 10 | 18 | 8 | 2 | 6 |
ATRN MUTATED | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 |
ATRN WILD-TYPE | 34 | 21 | 19 | 10 | 17 | 8 | 2 | 6 |
P value = 0.365 (Fisher's exact test), Q value = 0.65
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 30 | 30 | 14 |
ATRN MUTATED | 0 | 2 | 1 | 0 |
ATRN WILD-TYPE | 42 | 28 | 29 | 14 |
P value = 0.0633 (Fisher's exact test), Q value = 0.19
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 42 | 20 | 10 |
ATRN MUTATED | 0 | 1 | 2 | 0 |
ATRN WILD-TYPE | 44 | 41 | 18 | 10 |
P value = 0.338 (Fisher's exact test), Q value = 0.62
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 54 | 61 | 5 |
ATRN MUTATED | 0 | 3 | 0 |
ATRN WILD-TYPE | 54 | 58 | 5 |
P value = 0.161 (Fisher's exact test), Q value = 0.36
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 26 | 18 | 26 | 7 | 16 | 27 |
ATRN MUTATED | 0 | 0 | 0 | 0 | 2 | 1 |
ATRN WILD-TYPE | 26 | 18 | 26 | 7 | 14 | 26 |
P value = 0.251 (Fisher's exact test), Q value = 0.48
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 25 | 51 | 43 | 1 |
ATRN MUTATED | 0 | 3 | 0 | 0 |
ATRN WILD-TYPE | 25 | 48 | 43 | 1 |
P value = 0.493 (Fisher's exact test), Q value = 0.77
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 26 | 33 | 33 | 28 |
ATRN MUTATED | 0 | 2 | 0 | 1 |
ATRN WILD-TYPE | 26 | 31 | 33 | 27 |
P value = 0.903 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 35 | 27 | 19 | 29 | 10 |
NRAS MUTATED | 1 | 0 | 1 | 1 | 0 |
NRAS WILD-TYPE | 34 | 27 | 18 | 28 | 10 |
P value = 0.397 (Fisher's exact test), Q value = 0.69
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 34 | 23 | 19 | 10 | 18 | 8 | 2 | 6 |
NRAS MUTATED | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
NRAS WILD-TYPE | 34 | 22 | 18 | 9 | 18 | 8 | 2 | 6 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 30 | 30 | 14 |
NRAS MUTATED | 1 | 1 | 1 | 0 |
NRAS WILD-TYPE | 41 | 29 | 29 | 14 |
P value = 0.197 (Fisher's exact test), Q value = 0.39
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 42 | 20 | 10 |
NRAS MUTATED | 1 | 0 | 1 | 1 |
NRAS WILD-TYPE | 43 | 42 | 19 | 9 |
P value = 0.645 (Fisher's exact test), Q value = 0.9
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 54 | 61 | 5 |
NRAS MUTATED | 2 | 1 | 0 |
NRAS WILD-TYPE | 52 | 60 | 5 |
P value = 0.721 (Fisher's exact test), Q value = 0.96
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 26 | 18 | 26 | 7 | 16 | 27 |
NRAS MUTATED | 1 | 0 | 1 | 0 | 1 | 0 |
NRAS WILD-TYPE | 25 | 18 | 25 | 7 | 15 | 27 |
P value = 0.609 (Fisher's exact test), Q value = 0.9
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 25 | 51 | 43 | 1 |
NRAS MUTATED | 0 | 1 | 2 | 0 |
NRAS WILD-TYPE | 25 | 50 | 41 | 1 |
P value = 0.892 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 26 | 33 | 33 | 28 |
NRAS MUTATED | 1 | 1 | 1 | 0 |
NRAS WILD-TYPE | 25 | 32 | 32 | 28 |
P value = 0.0154 (Fisher's exact test), Q value = 0.065
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 35 | 27 | 19 | 29 | 10 |
PLEKHG4B MUTATED | 0 | 0 | 0 | 1 | 2 |
PLEKHG4B WILD-TYPE | 35 | 27 | 19 | 28 | 8 |
P value = 0.12 (Fisher's exact test), Q value = 0.3
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 34 | 23 | 19 | 10 | 18 | 8 | 2 | 6 |
PLEKHG4B MUTATED | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
PLEKHG4B WILD-TYPE | 34 | 22 | 19 | 9 | 18 | 8 | 2 | 5 |
P value = 0.503 (Fisher's exact test), Q value = 0.77
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 30 | 30 | 14 |
PLEKHG4B MUTATED | 1 | 0 | 1 | 1 |
PLEKHG4B WILD-TYPE | 41 | 30 | 29 | 13 |
P value = 0.197 (Fisher's exact test), Q value = 0.39
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 42 | 20 | 10 |
PLEKHG4B MUTATED | 1 | 0 | 1 | 1 |
PLEKHG4B WILD-TYPE | 43 | 42 | 19 | 9 |
P value = 0.648 (Fisher's exact test), Q value = 0.9
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 54 | 61 | 5 |
PLEKHG4B MUTATED | 2 | 1 | 0 |
PLEKHG4B WILD-TYPE | 52 | 60 | 5 |
P value = 0.294 (Fisher's exact test), Q value = 0.55
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 26 | 18 | 26 | 7 | 16 | 27 |
PLEKHG4B MUTATED | 1 | 0 | 0 | 1 | 0 | 1 |
PLEKHG4B WILD-TYPE | 25 | 18 | 26 | 6 | 16 | 26 |
P value = 0.609 (Fisher's exact test), Q value = 0.9
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 25 | 51 | 43 | 1 |
PLEKHG4B MUTATED | 0 | 1 | 2 | 0 |
PLEKHG4B WILD-TYPE | 25 | 50 | 41 | 1 |
P value = 0.79 (Fisher's exact test), Q value = 1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 26 | 33 | 33 | 28 |
PLEKHG4B MUTATED | 1 | 0 | 1 | 1 |
PLEKHG4B WILD-TYPE | 25 | 33 | 32 | 27 |
P value = 0.0463 (Fisher's exact test), Q value = 0.15
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 35 | 27 | 19 | 29 | 10 |
UNC93B1 MUTATED | 0 | 4 | 0 | 1 | 0 |
UNC93B1 WILD-TYPE | 35 | 23 | 19 | 28 | 10 |
P value = 0.178 (Fisher's exact test), Q value = 0.39
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 34 | 23 | 19 | 10 | 18 | 8 | 2 | 6 |
UNC93B1 MUTATED | 0 | 3 | 0 | 0 | 1 | 1 | 0 | 0 |
UNC93B1 WILD-TYPE | 34 | 20 | 19 | 10 | 17 | 7 | 2 | 6 |
P value = 0.676 (Fisher's exact test), Q value = 0.92
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 31 | 25 | 31 |
UNC93B1 MUTATED | 1 | 2 | 1 |
UNC93B1 WILD-TYPE | 30 | 23 | 30 |
P value = 0.185 (Fisher's exact test), Q value = 0.39
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 16 | 23 | 28 | 20 |
UNC93B1 MUTATED | 0 | 3 | 1 | 0 |
UNC93B1 WILD-TYPE | 16 | 20 | 27 | 20 |
P value = 0.149 (Fisher's exact test), Q value = 0.35
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 42 | 30 | 30 | 14 |
UNC93B1 MUTATED | 0 | 2 | 3 | 0 |
UNC93B1 WILD-TYPE | 42 | 28 | 27 | 14 |
P value = 0.155 (Fisher's exact test), Q value = 0.36
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 42 | 20 | 10 |
UNC93B1 MUTATED | 0 | 3 | 2 | 0 |
UNC93B1 WILD-TYPE | 44 | 39 | 18 | 10 |
P value = 0.084 (Fisher's exact test), Q value = 0.22
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 54 | 61 | 5 |
UNC93B1 MUTATED | 0 | 5 | 0 |
UNC93B1 WILD-TYPE | 54 | 56 | 5 |
P value = 0.145 (Fisher's exact test), Q value = 0.35
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 26 | 18 | 26 | 7 | 16 | 27 |
UNC93B1 MUTATED | 0 | 2 | 0 | 0 | 2 | 1 |
UNC93B1 WILD-TYPE | 26 | 16 | 26 | 7 | 14 | 26 |
P value = 0.0762 (Fisher's exact test), Q value = 0.21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 25 | 51 | 43 | 1 |
UNC93B1 MUTATED | 0 | 5 | 0 | 0 |
UNC93B1 WILD-TYPE | 25 | 46 | 43 | 1 |
P value = 0.0557 (Fisher's exact test), Q value = 0.17
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 26 | 33 | 33 | 28 |
UNC93B1 MUTATED | 0 | 4 | 0 | 1 |
UNC93B1 WILD-TYPE | 26 | 29 | 33 | 27 |
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Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline
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Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/THYM-TP/22571832/transformed.cor.cli.txt
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Molecular subtypes file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/THYM-TP/22541006/THYM-TP.transferedmergedcluster.txt
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Number of patients = 120
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Number of significantly mutated genes = 8
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Number of Molecular subtypes = 10
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Exclude genes that fewer than K tumors have mutations, K = 3
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.