Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	36.0	3196.0	88.0	-0.543	0.113	1000.0	-1000.0	-0.057	-1000.0
Signaling mediated by p38-alpha and p38-beta	34.0	1533.0	44.0	-0.353	0.032	1000.0	-1000.0	-0.006	-1000.0
Class IB PI3K non-lipid kinase events	33.0	99.0	3.0	-0.116	-1000.0	1000.0	-1000.0	-0.019	-1000.0
Nongenotropic Androgen signaling	32.0	1673.0	52.0	-0.439	0.276	1000.0	-1000.0	-0.022	-1000.0
PDGFR-alpha signaling pathway	26.0	1181.0	44.0	-0.557	0.058	1000.0	-1000.0	-0.027	-1000.0
Endothelins	26.0	2542.0	96.0	-0.583	0.059	1000.0	-1000.0	-0.037	-1000.0
IL4-mediated signaling events	25.0	2293.0	91.0	-0.872	0.564	1000.0	-1000.0	-0.025	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	22.0	771.0	34.0	-0.123	0.033	1000.0	-1000.0	-0.022	-1000.0
Reelin signaling pathway	22.0	1253.0	56.0	-0.19	0.062	1000.0	-1000.0	-0.014	-1000.0
HIF-1-alpha transcription factor network	21.0	1611.0	76.0	-0.293	0.047	1000.0	-1000.0	-0.032	-1000.0
Calcium signaling in the CD4+ TCR pathway	21.0	652.0	31.0	-0.354	0.032	1000.0	-1000.0	-0.048	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	20.0	1406.0	68.0	-0.494	0.108	1000.0	-1000.0	-0.036	-1000.0
Thromboxane A2 receptor signaling	19.0	2077.0	105.0	-0.263	0.076	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by the Hedgehog family	18.0	968.0	52.0	-0.344	0.037	1000.0	-1000.0	-0.015	-1000.0
Signaling events regulated by Ret tyrosine kinase	18.0	1534.0	82.0	-0.259	0.051	1000.0	-1000.0	-0.042	-1000.0
IL6-mediated signaling events	17.0	1349.0	75.0	-0.237	0.054	1000.0	-1000.0	-0.022	-1000.0
IL23-mediated signaling events	17.0	1028.0	60.0	-0.548	0.063	1000.0	-1000.0	-0.014	-1000.0
Osteopontin-mediated events	16.0	639.0	38.0	-0.238	0.035	1000.0	-1000.0	-0.015	-1000.0
TCGA08_retinoblastoma	14.0	114.0	8.0	-0.028	0.028	1000.0	-1000.0	-0.003	-1000.0
FOXM1 transcription factor network	14.0	743.0	51.0	-0.541	0.032	1000.0	-1000.0	-0.021	-1000.0
Coregulation of Androgen receptor activity	13.0	1022.0	76.0	-0.294	0.059	1000.0	-1000.0	-0.01	-1000.0
IL12-mediated signaling events	12.0	1114.0	87.0	-0.592	0.086	1000.0	-1000.0	-0.041	-1000.0
Glucocorticoid receptor regulatory network	12.0	1442.0	114.0	-0.504	0.182	1000.0	-1000.0	-0.042	-1000.0
S1P1 pathway	12.0	450.0	36.0	-0.353	0.031	1000.0	-1000.0	-0.022	-1000.0
Ras signaling in the CD4+ TCR pathway	12.0	208.0	17.0	-0.186	0.042	1000.0	-1000.0	-0.012	-1000.0
amb2 Integrin signaling	11.0	950.0	82.0	-0.282	0.04	1000.0	-1000.0	-0.024	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1047.0	93.0	-0.127	0.045	1000.0	-1000.0	-0.036	-1000.0
Wnt signaling	11.0	78.0	7.0	-0.125	0.022	1000.0	-1000.0	-0.003	-1000.0
ErbB2/ErbB3 signaling events	10.0	660.0	65.0	-0.23	0.044	1000.0	-1000.0	-0.056	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	10.0	568.0	54.0	-0.19	0.047	1000.0	-1000.0	-0.022	-1000.0
Fc-epsilon receptor I signaling in mast cells	10.0	1055.0	97.0	-0.237	0.033	1000.0	-1000.0	-0.051	-1000.0
Integrins in angiogenesis	10.0	893.0	84.0	-0.101	0.054	1000.0	-1000.0	-0.021	-1000.0
Noncanonical Wnt signaling pathway	9.0	248.0	26.0	-0.135	0.032	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by PTP1B	9.0	722.0	76.0	-0.202	0.048	1000.0	-1000.0	-0.034	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	9.0	486.0	52.0	-0.155	0.068	1000.0	-1000.0	-0.021	-1000.0
PDGFR-beta signaling pathway	9.0	965.0	97.0	-0.099	0.039	1000.0	-1000.0	-0.032	-1000.0
BARD1 signaling events	8.0	501.0	57.0	-0.066	0.06	1000.0	-1000.0	-0.035	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	136.0	17.0	-0.115	0.032	1000.0	-1000.0	-0.023	-1000.0
Arf6 signaling events	8.0	534.0	62.0	-0.22	0.063	1000.0	-1000.0	-0.021	-1000.0
BMP receptor signaling	8.0	685.0	81.0	-0.202	0.062	1000.0	-1000.0	-0.023	-1000.0
Glypican 1 network	8.0	387.0	48.0	-0.13	0.053	1000.0	-1000.0	-0.017	-1000.0
Retinoic acid receptors-mediated signaling	8.0	473.0	58.0	-0.142	0.062	1000.0	-1000.0	-0.019	-1000.0
Regulation of Androgen receptor activity	8.0	575.0	70.0	-0.163	0.044	1000.0	-1000.0	-0.041	-1000.0
FOXA2 and FOXA3 transcription factor networks	7.0	327.0	46.0	-0.648	0.036	1000.0	-1000.0	-0.016	-1000.0
BCR signaling pathway	7.0	731.0	99.0	-0.155	0.059	1000.0	-1000.0	-0.046	-1000.0
Insulin Pathway	7.0	549.0	74.0	-0.317	0.074	1000.0	-1000.0	-0.028	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	7.0	957.0	120.0	-0.372	0.172	1000.0	-1000.0	-0.033	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	886.0	136.0	-0.283	0.073	1000.0	-1000.0	-0.032	-1000.0
Nectin adhesion pathway	6.0	395.0	63.0	-0.073	0.08	1000.0	-1000.0	-0.04	-1000.0
LPA receptor mediated events	6.0	612.0	102.0	-0.237	0.033	1000.0	-1000.0	-0.055	-1000.0
Syndecan-4-mediated signaling events	6.0	441.0	67.0	-0.186	0.046	1000.0	-1000.0	-0.025	-1000.0
Aurora B signaling	6.0	435.0	67.0	-0.452	0.072	1000.0	-1000.0	-0.027	-1000.0
Syndecan-2-mediated signaling events	5.0	412.0	69.0	-0.186	0.046	1000.0	-1000.0	-0.025	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	29.0	5.0	-0.008	0.023	1000.0	-1000.0	0.017	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	437.0	85.0	-0.397	0.063	1000.0	-1000.0	-0.029	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	360.0	61.0	-0.237	0.082	1000.0	-1000.0	-0.036	-1000.0
FAS signaling pathway (CD95)	5.0	263.0	47.0	-0.436	0.048	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	5.0	327.0	58.0	-0.186	0.05	1000.0	-1000.0	-0.029	-1000.0
LPA4-mediated signaling events	4.0	59.0	12.0	-0.115	0.009	1000.0	-1000.0	-0.018	-1000.0
Syndecan-1-mediated signaling events	4.0	157.0	34.0	-0.127	0.032	1000.0	-1000.0	-0.017	-1000.0
Plasma membrane estrogen receptor signaling	4.0	402.0	86.0	-0.062	0.057	1000.0	-1000.0	-0.039	-1000.0
p75(NTR)-mediated signaling	3.0	495.0	125.0	-0.127	0.081	1000.0	-1000.0	-0.048	-1000.0
PLK1 signaling events	3.0	273.0	85.0	-0.034	0.052	1000.0	-1000.0	-0.03	-1000.0
Ceramide signaling pathway	3.0	256.0	76.0	-0.062	0.089	1000.0	-1000.0	-0.02	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	118.0	37.0	-0.026	0.051	1000.0	-1000.0	-0.018	-1000.0
IL1-mediated signaling events	3.0	201.0	62.0	-0.053	0.076	1000.0	-1000.0	-0.022	-1000.0
ceramide signaling pathway	3.0	154.0	49.0	-0.019	0.046	1000.0	-1000.0	-0.016	-1000.0
HIF-2-alpha transcription factor network	3.0	143.0	43.0	-0.102	0.104	1000.0	-1000.0	-0.047	-1000.0
Ephrin B reverse signaling	3.0	172.0	48.0	-0.073	0.051	1000.0	-1000.0	-0.02	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	111.0	36.0	-0.043	0.054	1000.0	-1000.0	-0.022	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	137.0	45.0	-0.035	0.082	1000.0	-1000.0	-0.029	-1000.0
Canonical Wnt signaling pathway	3.0	154.0	51.0	-0.07	0.074	1000.0	-1000.0	-0.033	-1000.0
Glypican 2 network	3.0	12.0	4.0	0.013	0.023	1000.0	-1000.0	0.016	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	377.0	125.0	-0.073	0.062	1000.0	-1000.0	-0.03	-1000.0
IL27-mediated signaling events	3.0	189.0	51.0	-0.188	0.061	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by STAT5	3.0	72.0	22.0	-0.052	0.036	1000.0	-1000.0	-0.02	-1000.0
IGF1 pathway	3.0	194.0	57.0	-0.021	0.068	1000.0	-1000.0	-0.021	-1000.0
Caspase cascade in apoptosis	2.0	160.0	74.0	-0.071	0.078	1000.0	-1000.0	-0.027	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	51.0	23.0	-0.057	0.061	1000.0	-1000.0	-0.01	-1000.0
ErbB4 signaling events	2.0	200.0	69.0	-0.104	0.062	1000.0	-1000.0	-0.017	-1000.0
Cellular roles of Anthrax toxin	2.0	101.0	39.0	-0.101	0.044	1000.0	-1000.0	-0.023	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	153.0	65.0	-0.013	0.077	1000.0	-1000.0	-0.028	-1000.0
Aurora C signaling	2.0	16.0	7.0	-0.006	0.027	1000.0	-1000.0	-0.008	-1000.0
mTOR signaling pathway	2.0	155.0	53.0	-0.022	0.042	1000.0	-1000.0	-0.032	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	216.0	83.0	-0.094	0.062	1000.0	-1000.0	-0.018	-1000.0
Atypical NF-kappaB pathway	2.0	68.0	31.0	-0.008	0.036	1000.0	-1000.0	-0.011	-1000.0
EPHB forward signaling	2.0	199.0	85.0	-0.129	0.076	1000.0	-1000.0	-0.047	-1000.0
Regulation of p38-alpha and p38-beta	2.0	154.0	54.0	-0.049	0.074	1000.0	-1000.0	-0.044	-1000.0
TCGA08_rtk_signaling	2.0	64.0	26.0	-0.156	0.043	1000.0	-1000.0	-0.01	-1000.0
Class I PI3K signaling events	2.0	165.0	73.0	-0.055	0.058	1000.0	-1000.0	-0.027	-1000.0
Regulation of Telomerase	2.0	227.0	102.0	-0.238	0.079	1000.0	-1000.0	-0.019	-1000.0
S1P3 pathway	2.0	91.0	42.0	-0.04	0.048	1000.0	-1000.0	-0.022	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	78.0	33.0	-0.036	0.078	1000.0	-1000.0	-0.021	-1000.0
Rapid glucocorticoid signaling	2.0	47.0	20.0	-0.011	0.034	1000.0	-1000.0	-0.004	-1000.0
Visual signal transduction: Rods	2.0	143.0	52.0	-0.165	0.078	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by PRL	2.0	99.0	34.0	-0.087	0.047	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	232.0	78.0	-0.028	0.066	1000.0	-1000.0	-0.031	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	33.0	28.0	-0.0	0.064	1000.0	-1000.0	-0.012	-1000.0
Aurora A signaling	1.0	73.0	60.0	-0.016	0.072	1000.0	-1000.0	-0.009	-1000.0
EPO signaling pathway	1.0	77.0	55.0	-0.009	0.085	1000.0	-1000.0	-0.021	-1000.0
IFN-gamma pathway	1.0	116.0	68.0	-0.0	0.081	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class III	1.0	55.0	40.0	-0.051	0.051	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	1.0	146.0	104.0	-0.055	0.077	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	1.0	100.0	64.0	-0.032	0.082	1000.0	-1000.0	-0.028	-1000.0
Effects of Botulinum toxin	1.0	39.0	26.0	-0.015	0.05	1000.0	-1000.0	-0.002	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	79.0	74.0	-0.06	0.07	1000.0	-1000.0	-0.048	-1000.0
Arf6 trafficking events	1.0	72.0	71.0	-0.055	0.057	1000.0	-1000.0	-0.025	-1000.0
VEGFR1 specific signals	1.0	79.0	56.0	-0.019	0.072	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling in keratinocytes	1.0	69.0	43.0	-0.024	0.052	1000.0	-1000.0	-0.015	-1000.0
S1P4 pathway	1.0	40.0	25.0	-0.0	0.049	1000.0	-1000.0	-0.017	-1000.0
Canonical NF-kappaB pathway	0.0	31.0	39.0	-0.015	0.072	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by HDAC Class II	0.0	61.0	75.0	-0.045	0.087	1000.0	-1000.0	-0.017	-1000.0
PLK2 and PLK4 events	0.0	1.0	3.0	0.019	-1000.0	1000.0	-1000.0	-0.004	-1000.0
Visual signal transduction: Cones	0.0	5.0	38.0	-0.007	0.072	1000.0	-1000.0	-0.006	-1000.0
Circadian rhythm pathway	0.0	7.0	22.0	-0.012	0.065	1000.0	-1000.0	-0.024	-1000.0
Ephrin A  reverse signaling	0.0	2.0	7.0	-0.0	0.032	1000.0	-1000.0	-0.0	-1000.0
Arf6 downstream pathway	0.0	22.0	43.0	-0.056	0.058	1000.0	-1000.0	-0.026	-1000.0
Insulin-mediated glucose transport	0.0	14.0	32.0	-0.0	0.06	1000.0	-1000.0	-0.016	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	38.0	68.0	-0.045	0.06	1000.0	-1000.0	-0.022	-1000.0
TRAIL signaling pathway	0.0	33.0	48.0	-0.0	0.078	1000.0	-1000.0	-0.017	-1000.0
S1P5 pathway	0.0	5.0	17.0	-0.035	0.039	1000.0	-1000.0	-0.008	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.007	0.027	1000.0	-1000.0	-0.008	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	11.0	15.0	-0.008	0.032	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	0.0	20.0	35.0	-0.023	0.081	1000.0	-1000.0	-0.021	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	47.0	76.0	-0.005	0.079	1000.0	-1000.0	-0.04	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	4.0	27.0	-0.0	0.078	1000.0	-1000.0	-0.023	-1000.0
EGFR-dependent Endothelin signaling events	0.0	12.0	21.0	-0.008	0.076	1000.0	-1000.0	-0.033	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.028	0.053	1000.0	-1000.0	0.018	-1000.0
p38 MAPK signaling pathway	0.0	26.0	44.0	-0.003	0.065	1000.0	-1000.0	-0.01	-1000.0
Arf1 pathway	0.0	16.0	54.0	-0.001	0.058	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.088	1000.0	-1000.0	0.0	-1000.0
Total	878	56650	7203	-19.6965398344	-1991.6395165	131000	-131000	-3.06841705625	-131000