Clinical Features Time to Death RADIATION_THERAPY HISTOLOGICAL_TYPE RESIDUAL_TUMOR nMutated (%) nWild-Type logrank test_P logrank test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q PTEN 161 (65%) 87 0.017368 0.76 0.099531 0.857 9.9999e-06 0.00197 0.04769 0.857 PIK3R1 82 (33%) 166 0.18422 0.857 0.40453 0.876 9.9999e-06 0.00197 0.95108 1 TP53 69 (28%) 179 0.0042475 0.298 0.66033 0.921 9.9999e-06 0.00197 0.04747 0.857 CTCF 44 (18%) 204 0.14002 0.857 0.86327 1 0.00022 0.0289 0.89534 1 FBXW7 38 (15%) 210 0.78973 0.966 0.58407 0.906 0.00291 0.229 0.4793 0.876 PIK3CA 131 (53%) 117 0.012226 0.602 1 1 0.28296 0.857 0.15113 0.857 ARID1A 83 (33%) 165 0.0016362 0.143 0.33185 0.857 6.9999e-05 0.011 0.25412 0.857 ARHGAP35 36 (15%) 212 0.92239 1 0.45888 0.876 0.72575 0.949 0.92522 1 KRAS 52 (21%) 196 0.068867 0.857 0.87156 1 0.00031 0.0349 0.492 0.876 CTNNB1 74 (30%) 174 0.65618 0.92 0.39066 0.876 9.9999e-06 0.00197 0.52933 0.906 ZFHX3 44 (18%) 204 0.57026 0.906 0.086018 0.857 0.066149 0.857 0.43482 0.876 SPOP 21 (8%) 227 0.2564 0.857 1 1 0.84249 0.998 0.56919 0.906 FGFR2 31 (12%) 217 0.29068 0.857 0.84329 0.998 0.78016 0.958 0.3615 0.858 TCP11L2 14 (6%) 234 0.067349 0.857 0.58249 0.906 0.16996 0.857 0.22739 0.857 VPS11 11 (4%) 237 0.51394 0.904 0.53815 0.906 1 1 1 1 PPP2R1A 28 (11%) 220 0.73311 0.949 0.68038 0.935 0.00085999 0.0847 1 1 MAX 9 (4%) 239 0.62577 0.906 1 1 0.45879 0.876 0.35078 0.857 SOX17 7 (3%) 241 0.38868 0.876 1 1 0.42452 0.876 0.67526 0.932 CCND1 14 (6%) 234 0.4391 0.876 0.39215 0.876 0.16973 0.857 0.25504 0.857 NRAS 9 (4%) 239 0.1687 0.857 0.49237 0.876 1 1 1 1 EP300 21 (8%) 227 0.27212 0.857 0.48552 0.876 0.066399 0.857 1 1 KLHL8 12 (5%) 236 0.48344 0.876 0.76328 0.952 0.28886 0.857 0.21235 0.857 ALG8 11 (4%) 237 0.65745 0.92 0.75066 0.949 0.35175 0.857 0.59304 0.906 GNPTAB 20 (8%) 228 0.076071 0.857 0.14637 0.857 0.26801 0.857 0.57817 0.906 SIN3A 21 (8%) 227 0.21433 0.857 0.15507 0.857 0.27645 0.857 0.8916 1 ARID5B 29 (12%) 219 0.82007 0.988 0.066007 0.857 0.01059 0.556 0.091499 0.857 NFE2L2 14 (6%) 234 0.49133 0.876 0.26668 0.857 0.17209 0.857 0.84825 0.998 ZNF471 15 (6%) 233 0.84435 0.998 0.26824 0.857 0.13969 0.857 0.35956 0.858 MORC4 20 (8%) 228 0.057713 0.857 0.81044 0.983 0.26999 0.857 1 1 SELP 10 (4%) 238 0.54013 0.906 0.33291 0.857 0.33476 0.857 0.24728 0.857 RBMX 12 (5%) 236 0.91434 1 0.76328 0.952 0.2906 0.857 0.078829 0.857 FAT1 40 (16%) 208 0.030735 0.857 0.85954 1 0.04557 0.857 0.77198 0.958 MARK3 11 (4%) 237 0.46955 0.876 0.75066 0.949 0.35351 0.857 0.19695 0.857 SOS1 12 (5%) 236 0.17834 0.857 1 1 0.28881 0.857 0.83573 0.998 RBBP6 22 (9%) 226 0.2057 0.857 0.81725 0.986 0.04331 0.857 0.49761 0.882 ZNF263 7 (3%) 241 0.27802 0.857 1 1 0.4262 0.876 0.20026 0.857 INTS7 8 (3%) 240 0.1687 0.857 0.71401 0.949 0.43722 0.876 0.52967 0.906 L1TD1 16 (6%) 232 0.11474 0.857 0.42477 0.876 0.1213 0.857 0.8777 1 NAT1 7 (3%) 241 0.89598 1 1 1 0.42913 0.876 0.4675 0.876 JAKMIP2 12 (5%) 236 0.35552 0.857 0.54361 0.906 0.28782 0.857 0.25873 0.857 ING1 12 (5%) 236 0.19562 0.857 0.76328 0.952 0.29051 0.857 1 1 CCDC6 6 (2%) 242 0.46017 0.876 1 1 0.36096 0.858 1 1 ZNF781 10 (4%) 238 0.2557 0.857 0.097469 0.857 0.33442 0.857 0.47897 0.876 MKI67 29 (12%) 219 0.078626 0.857 0.3124 0.857 0.0105 0.556 0.23588 0.857 EIF2S2 9 (4%) 239 0.22199 0.857 0.49237 0.876 0.45584 0.876 0.33912 0.857 BCOR 30 (12%) 218 0.071207 0.857 0.5451 0.906 0.0081399 0.493 0.36158 0.858 RASA1 21 (8%) 227 0.042908 0.857 0.24237 0.857 0.56656 0.906 1 1 DNER 18 (7%) 230 0.29853 0.857 0.80601 0.98 0.41557 0.876 0.62919 0.906 C9ORF23 9 (4%) 239 0.29495 0.857 1 1 0.45716 0.876 1 1 CUX1 21 (8%) 227 0.20773 0.857 0.81668 0.986 0.27477 0.857 0.8063 0.98 CDK17 14 (6%) 234 0.40185 0.876 0.26668 0.857 0.12588 0.857 0.2677 0.857 USP28 10 (4%) 238 0.12687 0.857 0.33291 0.857 0.33321 0.857 0.77841 0.958 MSH6 17 (7%) 231 0.2225 0.857 1 1 0.49096 0.876 0.5998 0.906 WDR45 11 (4%) 237 0.66521 0.924 1 1 0.355 0.857 0.52718 0.906 C14ORF166B 9 (4%) 239 0.20528 0.857 0.028387 0.857 0.45548 0.876 1 1 ATM 29 (12%) 219 0.016073 0.745 0.3124 0.857 0.074459 0.857 0.90327 1 RAE1 11 (4%) 237 0.17156 0.857 0.059486 0.857 0.74298 0.949 1 1 ZNF485 9 (4%) 239 0.83957 0.998 0.16065 0.857 0.45575 0.876 0.069099 0.857 POLE 27 (11%) 221 0.27642 0.857 0.29096 0.857 0.12729 0.857 0.39858 0.876 AHCYL1 6 (2%) 242 0.29549 0.857 1 1 0.63185 0.906 0.39584 0.876 ZNF334 17 (7%) 231 0.4669 0.876 0.60945 0.906 0.80733 0.98 0.59896 0.906 SACS 26 (10%) 222 0.091456 0.857 0.66777 0.926 0.12219 0.857 0.62562 0.906 MSH4 15 (6%) 233 0.089088 0.857 0.58209 0.906 0.14182 0.857 0.62807 0.906 SLC26A8 12 (5%) 236 0.18408 0.857 0.54361 0.906 0.28846 0.857 0.68859 0.937 KIF20B 21 (8%) 227 0.21241 0.857 0.48552 0.876 0.065439 0.857 0.90437 1 RRAS2 4 (2%) 244 0.48502 0.876 0.62571 0.906 1 1 0.43028 0.876 CTNND1 19 (8%) 229 0.55855 0.906 1 1 0.42957 0.876 0.37716 0.876 NFE2L3 12 (5%) 236 0.9561 1 0.36547 0.865 0.21843 0.857 0.4074 0.876 FAM65B 16 (6%) 232 0.080644 0.857 0.79104 0.966 0.47796 0.876 0.86264 1 RNF43 12 (5%) 236 0.14805 0.857 0.034289 0.857 0.28834 0.857 0.63811 0.906 MRPL47 6 (2%) 242 0.37236 0.871 0.41908 0.876 1 1 0.46716 0.876 TIGD4 13 (5%) 235 0.14664 0.857 0.77311 0.958 0.29975 0.857 0.59241 0.906 FILIP1 16 (6%) 232 0.065581 0.857 1 1 0.47267 0.876 0.59412 0.906 SLC1A3 12 (5%) 236 0.52795 0.906 1 1 1 1 0.64022 0.907 UFSP2 11 (4%) 237 0.14422 0.857 1 1 0.3507 0.857 0.68291 0.935 WBP4 8 (3%) 240 0.33925 0.857 0.26418 0.857 0.43804 0.876 1 1 TRIM59 9 (4%) 239 0.24155 0.857 0.49237 0.876 0.45445 0.876 1 1 RSBN1L 12 (5%) 236 0.10554 0.857 0.54361 0.906 0.75402 0.949 0.15565 0.857 SERHL2 6 (2%) 242 0.23884 0.857 0.19597 0.857 0.63475 0.906 1 1 OR52I2 8 (3%) 240 0.73112 0.949 1 1 0.15587 0.857 0.78033 0.958 SGK1 13 (5%) 235 0.51921 0.906 1 1 0.57243 0.906 0.0486 0.857 LNX2 14 (6%) 234 0.11899 0.857 0.089987 0.857 0.17055 0.857 0.76337 0.952 ALPK2 19 (8%) 229 0.039568 0.857 0.33046 0.857 0.42948 0.876 0.23984 0.857 REV3L 20 (8%) 228 0.061162 0.857 0.33616 0.857 0.069079 0.857 0.91567 1 CAB39L 8 (3%) 240 0.22836 0.857 0.26418 0.857 0.43653 0.876 1 1 ERBB3 17 (7%) 231 0.12083 0.857 0.79538 0.97 0.49154 0.876 0.27414 0.857 INPP4B 12 (5%) 236 0.39915 0.876 0.004531 0.298 0.28938 0.857 0.1669 0.857 C1ORF100 9 (4%) 239 0.13102 0.857 1 1 0.45614 0.876 0.46569 0.876 IL20 7 (3%) 241 0.23156 0.857 0.70959 0.949 0.42403 0.876 0.10335 0.857 SLC44A3 6 (2%) 242 0.29691 0.857 1 1 0.63356 0.906 0.60881 0.906 TAP1 8 (3%) 240 0.60974 0.906 0.71401 0.949 0.43367 0.876 1 1 RHBDD3 4 (2%) 244 0.39369 0.876 0.62571 0.906 1 1 1 1 BRDT 14 (6%) 234 0.12124 0.857 0.089987 0.857 0.17116 0.857 0.63137 0.906 RB1 20 (8%) 228 0.1791 0.857 0.14637 0.857 0.068789 0.857 0.86601 1 MFAP5 9 (4%) 239 0.23173 0.857 1 1 1 1 0.52936 0.906 NAA15 14 (6%) 234 0.30402 0.857 0.77622 0.958 0.58382 0.906 0.76339 0.952 ZRANB3 7 (3%) 241 0.20437 0.857 0.70959 0.949 1 1 1 1 SLC34A3 6 (2%) 242 0.36651 0.865 0.6719 0.929 0.63012 0.906 1 1 MLH3 17 (7%) 231 0.36962 0.869 0.60945 0.906 0.49124 0.876 0.24002 0.857 CCDC147 15 (6%) 233 0.12966 0.857 0.26824 0.857 0.46824 0.876 0.58889 0.906 ZNF662 13 (5%) 235 0.10726 0.857 0.77311 0.958 0.57802 0.906 0.63691 0.906 PSMC4 11 (4%) 237 0.19764 0.857 1 1 0.35148 0.857 0.84727 0.998 CCDC160 11 (4%) 237 0.14794 0.857 0.75066 0.949 0.3501 0.857 0.83172 0.996 PPIL4 11 (4%) 237 0.20748 0.857 0.53815 0.906 0.74497 0.949 0.59339 0.906 CCDC144A 18 (7%) 230 0.31414 0.857 0.21453 0.857 0.66001 0.921 0.29374 0.857 TUBGCP6 20 (8%) 228 0.42614 0.876 0.63199 0.906 0.068239 0.857 0.37746 0.876 TTC39C 7 (3%) 241 0.25453 0.857 0.049482 0.857 0.42672 0.876 1 1 COL8A1 10 (4%) 238 0.67022 0.928 1 1 0.33539 0.857 0.46668 0.876 PER3 12 (5%) 236 0.15405 0.857 0.54361 0.906 0.28756 0.857 1 1 MGA 26 (10%) 222 0.96569 1 1 1 0.34969 0.857 0.14644 0.857 GPRASP1 21 (8%) 227 0.20087 0.857 0.81668 0.986 0.27542 0.857 0.58469 0.906 PPM1D 11 (4%) 237 0.15628 0.857 0.059486 0.857 0.35239 0.857 0.58373 0.906 ZNF674 14 (6%) 234 0.08297 0.857 0.58249 0.906 0.5816 0.906 0.51783 0.906 LIMK2 12 (5%) 236 0.21184 0.857 0.54361 0.906 0.75415 0.949 0.6845 0.935 ZNF606 16 (6%) 232 0.30095 0.857 0.17981 0.857 0.11962 0.857 0.49807 0.882 SFRP4 8 (3%) 240 0.19741 0.857 0.71401 0.949 0.43843 0.876 0.33576 0.857 TXNRD1 8 (3%) 240 0.13649 0.857 0.26418 0.857 0.43575 0.876 0.34911 0.857 LETMD1 6 (2%) 242 0.19541 0.857 1 1 0.63209 0.906 0.052449 0.857 ZNF721 13 (5%) 235 0.16027 0.857 0.38379 0.876 0.30443 0.857 0.63432 0.906 RASSF9 9 (4%) 239 0.20413 0.857 0.16065 0.857 0.45475 0.876 0.58952 0.906 AGXT2 11 (4%) 237 0.77575 0.958 0.75066 0.949 0.35091 0.857 0.63436 0.906 MECOM 12 (5%) 236 0.10897 0.857 0.54361 0.906 0.28822 0.857 1 1 ATP6V1C2 12 (5%) 236 0.13637 0.857 1 1 0.29055 0.857 0.83502 0.998 DYM 10 (4%) 238 0.82893 0.994 0.74991 0.949 0.74481 0.949 1 1 TAB3 18 (7%) 230 0.069586 0.857 0.46028 0.876 0.086369 0.857 0.25919 0.857 ZNF649 14 (6%) 234 0.1171 0.857 0.26668 0.857 0.17217 0.857 0.76091 0.952 FN1 24 (10%) 224 0.16015 0.857 0.82559 0.992 0.02186 0.857 0.37271 0.871 CCDC150 11 (4%) 237 0.24553 0.857 0.75066 0.949 0.74276 0.949 0.84821 0.998 KIF21A 15 (6%) 233 0.10936 0.857 0.05751 0.857 0.13978 0.857 0.59054 0.906 BHLHB9 8 (3%) 240 0.23641 0.857 1 1 0.43545 0.876 0.73161 0.949 EXOSC9 10 (4%) 238 0.71988 0.949 0.33291 0.857 0.33183 0.857 0.58569 0.906 ZKSCAN1 7 (3%) 241 0.32884 0.857 0.70959 0.949 1 1 0.73631 0.949 OR8B8 7 (3%) 241 0.27273 0.857 0.42804 0.876 0.42822 0.876 0.39873 0.876 SENP7 12 (5%) 236 0.38122 0.876 0.54361 0.906 0.28982 0.857 0.68608 0.935 WDR65 6 (2%) 242 0.43164 0.876 0.41908 0.876 0.63442 0.906 1 1 NRIP1 13 (5%) 235 0.41716 0.876 0.38379 0.876 0.57436 0.906 0.40743 0.876 MCTP1 13 (5%) 235 0.13358 0.857 1 1 0.57566 0.906 0.63581 0.906 CCDC146 14 (6%) 234 0.12467 0.857 0.089987 0.857 0.17188 0.857 0.63535 0.906 ZNF620 9 (4%) 239 0.23944 0.857 0.49237 0.876 0.45815 0.876 0.73281 0.949 PTPN12 10 (4%) 238 0.6562 0.92 0.33291 0.857 0.33489 0.857 0.58595 0.906 RIOK3 9 (4%) 239 0.23902 0.857 0.16065 0.857 0.4548 0.876 1 1 CASP8 17 (7%) 231 0.78664 0.964 0.60945 0.906 0.49069 0.876 0.52599 0.906 GFAP 6 (2%) 242 0.34133 0.857 1 1 0.63508 0.906 0.32356 0.857 OMA1 10 (4%) 238 0.23275 0.857 0.097469 0.857 0.33335 0.857 0.527 0.906 DENND3 15 (6%) 233 0.31344 0.857 0.41904 0.876 0.47399 0.876 0.87954 1 CHEK2 12 (5%) 236 0.55614 0.906 0.21951 0.857 0.75357 0.949 0.1343 0.857 ZMYM2 17 (7%) 231 0.26212 0.857 0.30386 0.857 0.099179 0.857 0.66152 0.921 EPC2 5 (2%) 243 0.2948 0.857 0.65486 0.92 0.62247 0.906 1 1 DEPDC1B 11 (4%) 237 0.7785 0.958 1 1 0.7444 0.949 0.1567 0.857 C3AR1 7 (3%) 241 0.12543 0.857 1 1 0.42752 0.876 0.52988 0.906 STK3 10 (4%) 238 0.19636 0.857 0.50469 0.89 0.33761 0.857 1 1 FOXJ3 10 (4%) 238 0.1838 0.857 0.74991 0.949 0.3349 0.857 0.63686 0.906 EPS8 12 (5%) 236 0.65059 0.92 1 1 0.75367 0.949 0.68358 0.935 ZNF385B 7 (3%) 241 0.3324 0.857 0.42804 0.876 0.42689 0.876 1 1 EFCAB4B 11 (4%) 237 0.13198 0.857 0.75066 0.949 0.35328 0.857 0.33616 0.857 NPRL2 5 (2%) 243 0.96312 1 0.65486 0.92 0.62233 0.906 0.2474 0.857 ATF6 14 (6%) 234 0.099607 0.857 1 1 0.58317 0.906 0.63243 0.906 LIMA1 8 (3%) 240 0.20303 0.857 0.71401 0.949 0.43878 0.876 1 1 PPIG 16 (6%) 232 0.14162 0.857 0.59622 0.906 0.11921 0.857 0.90427 1 ZNF774 10 (4%) 238 0.19367 0.857 0.74991 0.949 0.74088 0.949 0.58572 0.906 MUTED 7 (3%) 241 0.27257 0.857 0.42804 0.876 0.426 0.876 1 1 TPX2 6 (2%) 242 0.34584 0.857 1 1 0.63389 0.906 0.13237 0.857 PARG 9 (4%) 239 0.22603 0.857 1 1 0.45426 0.876 1 1 PSMD3 11 (4%) 237 0.14667 0.857 1 1 0.74488 0.949 1 1 STRN3 12 (5%) 236 0.16798 0.857 0.54361 0.906 0.75336 0.949 0.59464 0.906 MLL4 30 (12%) 218 0.022668 0.857 0.84029 0.998 0.04343 0.857 0.57244 0.906 MSN 15 (6%) 233 0.29127 0.857 1 1 0.59754 0.906 0.48276 0.876 MAPK8 11 (4%) 237 0.14711 0.857 0.33703 0.857 0.35241 0.857 0.30864 0.857 RBL2 12 (5%) 236 0.4579 0.876 1 1 0.28902 0.857 0.15857 0.857 PDGFRA 12 (5%) 236 0.41199 0.876 0.54361 0.906 0.28706 0.857 1 1 TMEM62 9 (4%) 239 0.22226 0.857 0.49237 0.876 0.45722 0.876 0.5855 0.906 RG9MTD3 8 (3%) 240 0.69891 0.948 0.26418 0.857 0.68149 0.935 0.34968 0.857 KANK4 11 (4%) 237 0.84028 0.998 0.75066 0.949 0.74748 0.949 1 1 MYOM1 23 (9%) 225 0.7794 0.958 0.8227 0.99 0.84837 0.998 0.43902 0.876 MORC3 10 (4%) 238 0.17585 0.857 1 1 0.73942 0.949 0.40015 0.876 CCDC82 12 (5%) 236 0.47274 0.876 0.54361 0.906 0.28996 0.857 0.59295 0.906 B3GALT5 4 (2%) 244 0.50371 0.89 0.29972 0.857 1 1 1 1 NOC3L 11 (4%) 237 0.15484 0.857 0.33703 0.857 0.35295 0.857 0.63804 0.906 NSUN4 6 (2%) 242 0.31709 0.857 0.41908 0.876 1 1 0.60889 0.906 ASXL2 14 (6%) 234 0.10297 0.857 0.58249 0.906 0.58355 0.906 0.20405 0.857 CHD4 35 (14%) 213 0.69488 0.944 0.34577 0.857 0.45355 0.876 1 1 FCN1 7 (3%) 241 0.9456 1 1 1 0.42703 0.876 1 1 NIPA2 8 (3%) 240 0.27983 0.857 0.71401 0.949 1 1 1 1 C14ORF118 13 (5%) 235 0.17168 0.857 0.14094 0.857 0.30202 0.857 0.72618 0.949 THAP5 6 (2%) 242 0.32554 0.857 0.088318 0.857 0.6342 0.906 1 1 ZNF611 12 (5%) 236 0.63665 0.906 1 1 0.28698 0.857 0.16633 0.857 ZCCHC18 6 (2%) 242 0.34791 0.857 0.088318 0.857 0.63375 0.906 1 1 PRKCE 9 (4%) 239 0.19599 0.857 0.72831 0.949 0.45647 0.876 1 1 BMP2K 13 (5%) 235 0.16088 0.857 0.38379 0.876 0.30305 0.857 0.68488 0.935 PRPF38B 11 (4%) 237 0.2111 0.857 0.75066 0.949 0.3511 0.857 0.63528 0.906 LGMN 7 (3%) 241 0.36117 0.858 0.70959 0.949 0.42778 0.876 0.27964 0.857 SSH2 12 (5%) 236 0.17616 0.857 0.54361 0.906 0.7542 0.949 0.59317 0.906 EMR1 11 (4%) 237 0.1805 0.857 0.33703 0.857 0.35206 0.857 0.58721 0.906 OR5AK2 5 (2%) 243 0.2375 0.857 0.65486 0.92 0.62196 0.906 0.32227 0.857 C1ORF101 12 (5%) 236 0.16831 0.857 0.54361 0.906 0.28657 0.857 0.72475 0.949 ZNF534 9 (4%) 239 0.24886 0.857 0.49237 0.876 0.45587 0.876 0.58619 0.906 FAM122A 6 (2%) 242 0.99157 1 1 1 0.63429 0.906 0.28177 0.857