Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.086 0.215 -9999.0 0.0 -0.58 7.0 7.0 IHH -0.122 0.216 -9999.0 0.0 -0.476 15.0 15.0 SHH Np/Cholesterol/GAS1 -0.055 0.12 -9999.0 0.0 -0.247 16.0 16.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.055 0.119 0.245 16.0 -9999.0 0.0 16.0 SMO/beta Arrestin2 -0.049 0.148 -9999.0 0.0 -0.454 3.0 3.0 SMO -0.058 0.155 -9999.0 0.0 -0.482 3.0 3.0 AKT1 -0.015 0.077 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.022 0.126 -9999.0 0.0 -0.48 4.0 4.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.057 0.154 -9999.0 0.0 -0.437 4.0 4.0 STIL -0.066 0.158 -9999.0 0.0 -0.351 9.0 9.0 DHH N/PTCH2 -0.013 0.098 -9999.0 0.0 -0.329 5.0 5.0 DHH N/PTCH1 -0.075 0.15 -9999.0 0.0 -0.411 5.0 5.0 PIK3CA 0.004 0.062 -9999.0 0.0 -0.46 1.0 1.0 DHH -0.023 0.124 -9999.0 0.0 -0.473 4.0 4.0 PTHLH -0.118 0.288 -9999.0 0.0 -0.785 7.0 7.0 determination of left/right symmetry -0.057 0.154 -9999.0 0.0 -0.437 4.0 4.0 PIK3R1 -0.004 0.087 -9999.0 0.0 -0.46 2.0 2.0 skeletal system development -0.117 0.285 -9999.0 0.0 -0.776 7.0 7.0 IHH N/Hhip -0.174 0.223 -9999.0 0.0 -0.401 26.0 26.0 DHH N/Hhip -0.117 0.179 -9999.0 0.0 -0.345 21.0 21.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.057 0.154 -9999.0 0.0 -0.437 4.0 4.0 pancreas development -0.141 0.225 -9999.0 0.0 -0.473 18.0 18.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.076 -9999.0 0.0 -0.321 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.058 0.173 -9999.0 0.0 -0.486 8.0 8.0 somite specification -0.057 0.154 -9999.0 0.0 -0.437 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.075 0.165 -9999.0 0.0 -0.366 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.021 0.094 -9999.0 0.0 -0.237 9.0 9.0 SHH Np/Cholesterol/Megalin -0.099 0.144 -9999.0 0.0 -0.261 24.0 24.0 SHH -0.031 0.117 -9999.0 0.0 -0.321 8.0 8.0 catabolic process -0.07 0.159 -9999.0 0.0 -0.437 5.0 5.0 SMO/Vitamin D3 -0.068 0.164 -9999.0 0.0 -0.475 3.0 3.0 SHH Np/Cholesterol/Hhip -0.099 0.167 -9999.0 0.0 -0.303 21.0 21.0 LRP2 -0.14 0.223 -9999.0 0.0 -0.468 18.0 18.0 receptor-mediated endocytosis -0.111 0.162 -9999.0 0.0 -0.407 7.0 7.0 SHH Np/Cholesterol/BOC -0.035 0.107 -9999.0 0.0 -0.243 12.0 12.0 SHH Np/Cholesterol/CDO -0.016 0.089 -9999.0 0.0 -0.237 8.0 8.0 mesenchymal cell differentiation 0.099 0.165 0.301 21.0 -9999.0 0.0 21.0 mol:Vitamin D3 -0.074 0.167 -9999.0 0.0 -0.367 10.0 10.0 IHH N/PTCH2 -0.065 0.144 -9999.0 0.0 -0.37 6.0 6.0 CDON 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.07 0.161 -9999.0 0.0 -0.441 5.0 5.0 Megalin/LRPAP1 -0.091 0.16 -9999.0 0.0 -0.326 18.0 18.0 PTCH2 0.004 0.062 -9999.0 0.0 -0.46 1.0 1.0 SHH Np/Cholesterol -0.024 0.089 -9999.0 0.0 -0.244 8.0 8.0 PTCH1 -0.07 0.159 -9999.0 0.0 -0.438 5.0 5.0 HHIP -0.142 0.226 -9999.0 0.0 -0.473 18.0 18.0