Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	12.0	568.0	46.0	-0.676	0.03	1000.0	-1000.0	-0.106	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	719.0	82.0	-0.204	0.012	1000.0	-1000.0	-0.068	-1000.0
IL23-mediated signaling events	8.0	504.0	60.0	-0.433	0.012	1000.0	-1000.0	-0.156	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	7.0	248.0	34.0	-0.129	0.012	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by the Hedgehog family	7.0	413.0	52.0	-0.174	0.099	1000.0	-1000.0	-0.039	-1000.0
IL4-mediated signaling events	7.0	694.0	91.0	-0.744	0.615	1000.0	-1000.0	-0.166	-1000.0
TCGA08_retinoblastoma	7.0	61.0	8.0	-0.026	0.02	1000.0	-1000.0	-0.011	-1000.0
Syndecan-1-mediated signaling events	6.0	205.0	34.0	-0.191	0.012	1000.0	-1000.0	-0.04	-1000.0
p75(NTR)-mediated signaling	6.0	760.0	125.0	-0.208	0.032	1000.0	-1000.0	-0.083	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	599.0	93.0	-0.15	0.091	1000.0	-1000.0	-0.067	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	411.0	68.0	-0.266	0.161	1000.0	-1000.0	-0.112	-1000.0
IL12-mediated signaling events	5.0	486.0	87.0	-0.198	0.013	1000.0	-1000.0	-0.117	-1000.0
Ephrin A  reverse signaling	5.0	41.0	7.0	-0.058	0.003	1000.0	-1000.0	-0.01	-1000.0
HIF-1-alpha transcription factor network	5.0	434.0	76.0	-0.253	0.026	1000.0	-1000.0	-0.14	-1000.0
Glucocorticoid receptor regulatory network	5.0	586.0	114.0	-0.416	0.275	1000.0	-1000.0	-0.054	-1000.0
Endothelins	5.0	509.0	96.0	-0.135	0.012	1000.0	-1000.0	-0.07	-1000.0
Effects of Botulinum toxin	5.0	143.0	26.0	-0.226	0.016	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling events	5.0	28.0	5.0	-0.067	0.012	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	4.0	48.0	12.0	-0.09	0.016	1000.0	-1000.0	-0.018	-1000.0
BMP receptor signaling	4.0	329.0	81.0	-0.158	0.05	1000.0	-1000.0	-0.068	-1000.0
Glypican 1 network	4.0	227.0	48.0	-0.185	0.028	1000.0	-1000.0	-0.033	-1000.0
PDGFR-alpha signaling pathway	4.0	195.0	44.0	-0.222	0.019	1000.0	-1000.0	-0.041	-1000.0
amb2 Integrin signaling	4.0	369.0	82.0	-0.159	0.017	1000.0	-1000.0	-0.055	-1000.0
Reelin signaling pathway	4.0	254.0	56.0	-0.125	0.032	1000.0	-1000.0	-0.064	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	205.0	44.0	-0.096	0.012	1000.0	-1000.0	-0.037	-1000.0
Integrins in angiogenesis	4.0	341.0	84.0	-0.108	0.022	1000.0	-1000.0	-0.071	-1000.0
Syndecan-4-mediated signaling events	4.0	293.0	67.0	-0.121	0.018	1000.0	-1000.0	-0.051	-1000.0
Plasma membrane estrogen receptor signaling	4.0	383.0	86.0	-0.107	0.07	1000.0	-1000.0	-0.066	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	556.0	120.0	-0.16	0.114	1000.0	-1000.0	-0.059	-1000.0
Visual signal transduction: Rods	4.0	212.0	52.0	-0.101	0.015	1000.0	-1000.0	-0.059	-1000.0
Caspase cascade in apoptosis	3.0	230.0	74.0	-0.123	0.031	1000.0	-1000.0	-0.041	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	460.0	136.0	-0.244	0.177	1000.0	-1000.0	-0.049	-1000.0
Coregulation of Androgen receptor activity	3.0	252.0	76.0	-0.258	0.027	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	3.0	225.0	69.0	-0.194	0.088	1000.0	-1000.0	-0.067	-1000.0
Visual signal transduction: Cones	3.0	133.0	38.0	-0.066	0.012	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	3.0	196.0	62.0	-0.132	0.031	1000.0	-1000.0	-0.036	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	288.0	85.0	-0.132	0.012	1000.0	-1000.0	-0.054	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	186.0	61.0	-0.158	0.032	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by HDAC Class III	3.0	125.0	40.0	-0.152	0.121	1000.0	-1000.0	-0.02	-1000.0
TRAIL signaling pathway	3.0	171.0	48.0	-0.061	0.012	1000.0	-1000.0	-0.055	-1000.0
Retinoic acid receptors-mediated signaling	3.0	197.0	58.0	-0.166	0.025	1000.0	-1000.0	-0.062	-1000.0
Syndecan-3-mediated signaling events	3.0	122.0	35.0	-0.134	0.032	1000.0	-1000.0	-0.036	-1000.0
Canonical Wnt signaling pathway	3.0	166.0	51.0	-0.158	0.071	1000.0	-1000.0	-0.05	-1000.0
Wnt signaling	3.0	25.0	7.0	-0.065	-0.005	1000.0	-1000.0	-0.022	-1000.0
IL6-mediated signaling events	3.0	285.0	75.0	-0.161	0.042	1000.0	-1000.0	-0.065	-1000.0
IL2 signaling events mediated by STAT5	3.0	74.0	22.0	-0.129	0.013	1000.0	-1000.0	-0.042	-1000.0
BCR signaling pathway	3.0	299.0	99.0	-0.155	0.013	1000.0	-1000.0	-0.07	-1000.0
IGF1 pathway	3.0	198.0	57.0	-0.086	0.025	1000.0	-1000.0	-0.071	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	326.0	88.0	-0.125	0.018	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	285.0	78.0	-0.075	0.042	1000.0	-1000.0	-0.059	-1000.0
ErbB2/ErbB3 signaling events	2.0	181.0	65.0	-0.199	0.018	1000.0	-1000.0	-0.06	-1000.0
BARD1 signaling events	2.0	142.0	57.0	-0.058	0.036	1000.0	-1000.0	-0.043	-1000.0
Osteopontin-mediated events	2.0	79.0	38.0	-0.06	0.02	1000.0	-1000.0	-0.08	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	136.0	54.0	-0.125	0.023	1000.0	-1000.0	-0.082	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	49.0	17.0	-0.047	0.012	1000.0	-1000.0	-0.033	-1000.0
Noncanonical Wnt signaling pathway	2.0	77.0	26.0	-0.079	0.012	1000.0	-1000.0	-0.038	-1000.0
Thromboxane A2 receptor signaling	2.0	241.0	105.0	-0.092	0.025	1000.0	-1000.0	-0.054	-1000.0
Syndecan-2-mediated signaling events	2.0	167.0	69.0	-0.08	0.029	1000.0	-1000.0	-0.029	-1000.0
Cellular roles of Anthrax toxin	2.0	105.0	39.0	-0.091	0.012	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by PTP1B	2.0	205.0	76.0	-0.199	0.02	1000.0	-1000.0	-0.065	-1000.0
Nectin adhesion pathway	2.0	180.0	63.0	-0.067	0.024	1000.0	-1000.0	-0.055	-1000.0
S1P5 pathway	2.0	35.0	17.0	-0.048	0.013	1000.0	-1000.0	-0.028	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	151.0	52.0	-0.177	0.036	1000.0	-1000.0	-0.043	-1000.0
FAS signaling pathway (CD95)	2.0	119.0	47.0	-0.132	0.019	1000.0	-1000.0	-0.044	-1000.0
IL2 signaling events mediated by PI3K	2.0	126.0	58.0	-0.063	0.027	1000.0	-1000.0	-0.071	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	69.0	31.0	-0.112	0.012	1000.0	-1000.0	-0.061	-1000.0
Nongenotropic Androgen signaling	2.0	145.0	52.0	-0.073	0.012	1000.0	-1000.0	-0.042	-1000.0
IL27-mediated signaling events	2.0	123.0	51.0	-0.118	0.034	1000.0	-1000.0	-0.064	-1000.0
LPA receptor mediated events	2.0	283.0	102.0	-0.079	0.023	1000.0	-1000.0	-0.069	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	150.0	74.0	-0.132	0.035	1000.0	-1000.0	-0.071	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	206.0	76.0	-0.067	0.024	1000.0	-1000.0	-0.067	-1000.0
Rapid glucocorticoid signaling	2.0	42.0	20.0	-0.047	0.012	1000.0	-1000.0	-0.016	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.005	-1000.0	1000.0	-1000.0	-0.013	-1000.0
Regulation of Androgen receptor activity	2.0	164.0	70.0	-0.294	0.025	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by HDAC Class II	1.0	87.0	75.0	-0.107	0.029	1000.0	-1000.0	-0.032	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	29.0	28.0	-0.048	0.031	1000.0	-1000.0	-0.029	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.005	0.012	1000.0	-1000.0	-0.01	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	-0.005	0.012	1000.0	-1000.0	-0.018	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	75.0	65.0	-0.234	0.045	1000.0	-1000.0	-0.054	-1000.0
EPO signaling pathway	1.0	60.0	55.0	-0.024	0.036	1000.0	-1000.0	-0.069	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	136.0	97.0	-0.062	0.024	1000.0	-1000.0	-0.065	-1000.0
Insulin-mediated glucose transport	1.0	40.0	32.0	-0.108	0.025	1000.0	-1000.0	-0.042	-1000.0
Ceramide signaling pathway	1.0	102.0	76.0	-0.091	0.019	1000.0	-1000.0	-0.043	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	41.0	37.0	-0.055	0.027	1000.0	-1000.0	-0.037	-1000.0
IL1-mediated signaling events	1.0	88.0	62.0	-0.056	0.049	1000.0	-1000.0	-0.072	-1000.0
Ephrin B reverse signaling	1.0	73.0	48.0	-0.064	0.017	1000.0	-1000.0	-0.057	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	121.0	83.0	-0.133	0.055	1000.0	-1000.0	-0.064	-1000.0
S1P1 pathway	1.0	66.0	36.0	-0.071	0.012	1000.0	-1000.0	-0.054	-1000.0
Atypical NF-kappaB pathway	1.0	33.0	31.0	-0.039	0.023	1000.0	-1000.0	-0.027	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	69.0	45.0	-0.091	0.024	1000.0	-1000.0	-0.078	-1000.0
EPHB forward signaling	1.0	134.0	85.0	-0.109	0.038	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	190.0	125.0	-0.064	0.042	1000.0	-1000.0	-0.077	-1000.0
TCGA08_rtk_signaling	1.0	46.0	26.0	-0.046	0.013	1000.0	-1000.0	-0.017	-1000.0
Class I PI3K signaling events	1.0	98.0	73.0	-0.047	0.028	1000.0	-1000.0	-0.047	-1000.0
Regulation of Telomerase	1.0	121.0	102.0	-0.107	0.039	1000.0	-1000.0	-0.086	-1000.0
EGFR-dependent Endothelin signaling events	1.0	35.0	21.0	-0.031	0.018	1000.0	-1000.0	-0.057	-1000.0
S1P3 pathway	1.0	51.0	42.0	-0.049	0.023	1000.0	-1000.0	-0.033	-1000.0
PDGFR-beta signaling pathway	1.0	110.0	97.0	-0.109	0.038	1000.0	-1000.0	-0.062	-1000.0
E-cadherin signaling in keratinocytes	1.0	82.0	43.0	-0.067	0.013	1000.0	-1000.0	-0.043	-1000.0
FOXM1 transcription factor network	1.0	53.0	51.0	-0.079	0.106	1000.0	-1000.0	-0.186	-1000.0
S1P4 pathway	1.0	45.0	25.0	-0.048	0.018	1000.0	-1000.0	-0.031	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	29.0	17.0	-0.047	0.015	1000.0	-1000.0	-0.04	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	-0.032	0.039	1000.0	-1000.0	-0.037	-1000.0
Canonical NF-kappaB pathway	0.0	29.0	39.0	-0.091	0.067	1000.0	-1000.0	-0.07	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.012	0.043	1000.0	-1000.0	-0.039	-1000.0
Aurora A signaling	0.0	30.0	60.0	-0.066	0.033	1000.0	-1000.0	-0.035	-1000.0
Arf6 downstream pathway	0.0	11.0	43.0	-0.026	0.027	1000.0	-1000.0	-0.035	-1000.0
Aurora C signaling	0.0	2.0	7.0	-0.001	0.019	1000.0	-1000.0	-0.023	-1000.0
PLK1 signaling events	0.0	7.0	85.0	-0.01	0.033	1000.0	-1000.0	-0.033	-1000.0
mTOR signaling pathway	0.0	22.0	53.0	-0.007	0.024	1000.0	-1000.0	-0.05	-1000.0
IFN-gamma pathway	0.0	48.0	68.0	-0.122	0.048	1000.0	-1000.0	-0.08	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	32.0	68.0	-0.108	0.043	1000.0	-1000.0	-0.038	-1000.0
ceramide signaling pathway	0.0	42.0	49.0	-0.09	0.018	1000.0	-1000.0	-0.045	-1000.0
HIF-2-alpha transcription factor network	0.0	27.0	43.0	-0.085	0.087	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by HDAC Class I	0.0	72.0	104.0	-0.091	0.048	1000.0	-1000.0	-0.055	-1000.0
TCGA08_p53	0.0	4.0	7.0	-0.005	0.012	1000.0	-1000.0	-0.009	-1000.0
FoxO family signaling	0.0	36.0	64.0	-0.108	0.095	1000.0	-1000.0	-0.066	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	10.0	15.0	0.0	0.024	1000.0	-1000.0	-0.021	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.031	0.031	1000.0	-1000.0	-0.055	-1000.0
Regulation of p38-alpha and p38-beta	0.0	48.0	54.0	-0.082	0.037	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	0.0	3.0	4.0	0.003	0.012	1000.0	-1000.0	-0.009	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	0.0	0.028	1000.0	-1000.0	-0.038	-1000.0
Arf6 trafficking events	0.0	28.0	71.0	-0.042	0.037	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	0.0	28.0	74.0	-0.04	0.036	1000.0	-1000.0	-0.072	-1000.0
VEGFR1 specific signals	0.0	8.0	56.0	-0.005	0.045	1000.0	-1000.0	-0.047	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	26.0	33.0	-0.075	0.036	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PRL	0.0	31.0	34.0	-0.099	0.026	1000.0	-1000.0	-0.027	-1000.0
p38 MAPK signaling pathway	0.0	30.0	44.0	-0.022	0.025	1000.0	-1000.0	-0.057	-1000.0
Arf1 pathway	0.0	2.0	54.0	-0.0	0.026	1000.0	-1000.0	-0.022	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	0.0	0.032	1000.0	-1000.0	-0.02	-1000.0
Aurora B signaling	0.0	22.0	67.0	-0.097	0.031	1000.0	-1000.0	-0.055	-1000.0
Total	299	20906	7203	-14.7394309732	-994.921700391	131000	-131000	-6.91054738743	-131000