E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.031 0.142 -9999.0 0.0 -0.405 10.0 10.0 KLHL20 0.006 0.058 -9999.0 0.0 -0.142 9.0 9.0 CYFIP2 -0.047 0.151 -9999.0 0.0 -0.421 11.0 11.0 Rac1/GDP -0.002 0.09 -9999.0 0.0 -0.236 10.0 10.0 ENAH -0.036 0.144 -9999.0 0.0 -0.405 10.0 10.0 AP1M1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.004 0.048 -9999.0 0.0 -0.421 1.0 1.0 CDC42/GTP -0.021 0.056 -9999.0 0.0 -0.283 1.0 1.0 ABI1/Sra1/Nap1 -0.022 0.046 -9999.0 0.0 -0.162 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.013 0.089 -9999.0 0.0 -0.214 13.0 13.0 RAPGEF1 -0.021 0.125 -9999.0 0.0 -0.35 10.0 10.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.146 -9999.0 0.0 -0.42 10.0 10.0 CRK -0.026 0.135 -9999.0 0.0 -0.379 10.0 10.0 E-cadherin/gamma catenin/alpha catenin -0.01 0.082 -9999.0 0.0 -0.241 9.0 9.0 alphaE/beta7 Integrin 0.004 0.059 -9999.0 0.0 -0.293 3.0 3.0 IQGAP1 -0.012 0.094 -9999.0 0.0 -0.421 4.0 4.0 NCKAP1 0.004 0.048 -9999.0 0.0 -0.421 1.0 1.0 Rap1/GTP/I-afadin 0.013 0.037 -9999.0 0.0 -0.217 2.0 2.0 DLG1 -0.041 0.151 -9999.0 0.0 -0.424 10.0 10.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.023 0.049 -9999.0 0.0 -0.206 2.0 2.0 MLLT4 -0.001 0.067 -9999.0 0.0 -0.421 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.02 0.032 -9999.0 0.0 -0.217 1.0 1.0 PI3K -0.029 0.062 -9999.0 0.0 -0.266 2.0 2.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.02 0.097 -9999.0 0.0 -0.292 9.0 9.0 TIAM1 0.011 0.056 0.126 5.0 -0.421 1.0 6.0 E-cadherin(dimer)/Ca2+ -0.005 0.074 -9999.0 0.0 -0.2 10.0 10.0 AKT1 0.001 0.045 -9999.0 0.0 -0.152 2.0 2.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.039 0.136 -9999.0 0.0 -0.421 9.0 9.0 RhoA/GDP -0.003 0.09 -9999.0 0.0 -0.236 10.0 10.0 actin cytoskeleton organization 0.006 0.044 -9999.0 0.0 -0.104 10.0 10.0 CDC42/GDP -0.003 0.09 -9999.0 0.0 -0.236 10.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.011 0.07 -9999.0 0.0 -0.207 9.0 9.0 ITGB7 -0.005 0.083 0.126 1.0 -0.421 3.0 4.0 RAC1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.005 0.079 -9999.0 0.0 -0.214 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.01 0.073 -9999.0 0.0 -0.204 10.0 10.0 mol:GDP -0.01 0.101 -9999.0 0.0 -0.274 10.0 10.0 CDC42/GTP/IQGAP1 0.0 0.056 -9999.0 0.0 -0.245 4.0 4.0 JUP 0.011 0.013 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.003 0.091 -9999.0 0.0 -0.24 10.0 10.0 RAC1/GTP/IQGAP1 0.0 0.056 -9999.0 0.0 -0.245 4.0 4.0 PIP5K1C/AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.007 0.027 -9999.0 0.0 -0.082 1.0 1.0 NME1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.031 0.142 -9999.0 0.0 -0.405 10.0 10.0 regulation of cell-cell adhesion -0.019 0.05 -9999.0 0.0 -0.249 1.0 1.0 WASF2 -0.011 0.025 -9999.0 0.0 -0.086 5.0 5.0 Rap1/GTP 0.0 0.073 -9999.0 0.0 -0.184 10.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.005 0.081 -9999.0 0.0 -0.197 12.0 12.0 CCND1 0.008 0.033 -9999.0 0.0 -0.099 1.0 1.0 VAV2 -0.023 0.134 -9999.0 0.0 -0.375 10.0 10.0 RAP1/GDP 0.0 0.079 -9999.0 0.0 -0.203 10.0 10.0 adherens junction assembly -0.03 0.138 -9999.0 0.0 -0.393 10.0 10.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.005 0.08 -9999.0 0.0 -0.185 13.0 13.0 E-cadherin/beta catenin -0.024 0.1 -9999.0 0.0 -0.302 9.0 9.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.031 0.142 -9999.0 0.0 -0.405 10.0 10.0 PIK3CA -0.001 0.067 -9999.0 0.0 -0.421 2.0 2.0 Rac1/GTP -0.026 0.066 -9999.0 0.0 -0.197 10.0 10.0 E-cadherin/beta catenin/alpha catenin -0.013 0.086 -9999.0 0.0 -0.241 10.0 10.0 ITGAE 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.036 0.15 -9999.0 0.0 -0.429 10.0 10.0