Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.029 0.191 -9999.0 0.0 -0.503 10.0 10.0 IHH -0.001 0.12 0.164 1.0 -0.448 4.0 5.0 SHH Np/Cholesterol/GAS1 0.01 0.029 -9999.0 0.0 -0.221 1.0 1.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.01 0.029 0.22 1.0 -9999.0 0.0 1.0 SMO/beta Arrestin2 -0.007 0.12 -9999.0 0.0 -0.274 10.0 10.0 SMO -0.012 0.125 -9999.0 0.0 -0.29 10.0 10.0 AKT1 0.002 0.072 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.048 0.15 -9999.0 0.0 -0.421 11.0 11.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.124 -9999.0 0.0 -0.287 10.0 10.0 STIL -0.011 0.092 -9999.0 0.0 -0.203 10.0 10.0 DHH N/PTCH2 -0.004 0.076 -9999.0 0.0 -0.293 5.0 5.0 DHH N/PTCH1 -0.009 0.11 -9999.0 0.0 -0.237 14.0 14.0 PIK3CA -0.001 0.067 -9999.0 0.0 -0.421 2.0 2.0 DHH 0.006 0.052 -9999.0 0.0 -0.421 1.0 1.0 PTHLH -0.067 0.286 -9999.0 0.0 -0.778 10.0 10.0 determination of left/right symmetry -0.011 0.124 -9999.0 0.0 -0.287 10.0 10.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.066 0.283 -9999.0 0.0 -0.769 10.0 10.0 IHH N/Hhip 0.009 0.073 0.186 1.0 -0.253 4.0 5.0 DHH N/Hhip 0.011 0.039 -9999.0 0.0 -0.293 1.0 1.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.124 -9999.0 0.0 -0.287 10.0 10.0 pancreas development 0.009 0.019 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.007 0.048 -9999.0 0.0 -0.293 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.007 0.051 -9999.0 0.0 -0.421 1.0 1.0 somite specification -0.011 0.124 -9999.0 0.0 -0.287 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.005 0.095 -9999.0 0.0 -0.217 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.0 0.051 -9999.0 0.0 -0.22 4.0 4.0 SHH Np/Cholesterol/Megalin -0.015 0.104 0.12 1.0 -0.221 15.0 16.0 SHH 0.007 0.006 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.014 0.122 -9999.0 0.0 -0.274 14.0 14.0 SMO/Vitamin D3 -0.001 0.111 -9999.0 0.0 -0.243 6.0 6.0 SHH Np/Cholesterol/Hhip 0.011 0.015 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 -0.045 0.187 0.126 18.0 -0.421 15.0 33.0 receptor-mediated endocytosis -0.034 0.14 -9999.0 0.0 -0.403 5.0 5.0 SHH Np/Cholesterol/BOC -0.019 0.081 -9999.0 0.0 -0.22 11.0 11.0 SHH Np/Cholesterol/CDO 0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation -0.011 0.015 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.001 0.1 -9999.0 0.0 -0.217 10.0 10.0 IHH N/PTCH2 -0.007 0.101 -9999.0 0.0 -0.289 8.0 8.0 CDON 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.003 0.13 -9999.0 0.0 -0.276 14.0 14.0 Megalin/LRPAP1 -0.025 0.133 -9999.0 0.0 -0.293 15.0 15.0 PTCH2 -0.012 0.094 -9999.0 0.0 -0.421 4.0 4.0 SHH Np/Cholesterol 0.007 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.014 0.122 -9999.0 0.0 -0.275 14.0 14.0 HHIP 0.009 0.019 -9999.0 0.0 -9999.0 0.0 0.0