Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.016 0.092 -9999.0 0.0 -0.231 11.0 11.0 epithelial cell differentiation -0.007 0.072 -9999.0 0.0 -0.199 10.0 10.0 CYFIP2 -0.047 0.151 -9999.0 0.0 -0.421 11.0 11.0 ENAH 0.003 0.062 -9999.0 0.0 -0.179 3.0 3.0 EGFR 0.008 0.053 -9999.0 0.0 -0.421 1.0 1.0 EPHA2 0.004 0.048 -9999.0 0.0 -0.421 1.0 1.0 MYO6 -0.012 0.08 -9999.0 0.0 -0.205 11.0 11.0 CTNNB1 0.004 0.048 -9999.0 0.0 -0.421 1.0 1.0 ABI1/Sra1/Nap1 -0.018 0.095 -9999.0 0.0 -0.241 12.0 12.0 AQP5 -0.039 0.136 -9999.0 0.0 -0.376 9.0 9.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.006 0.067 -9999.0 0.0 -0.184 10.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.004 0.089 -9999.0 0.0 -0.201 12.0 12.0 EGF 0.002 0.118 -9999.0 0.0 -0.421 5.0 5.0 NCKAP1 0.004 0.048 -9999.0 0.0 -0.421 1.0 1.0 AQP3 -0.025 0.126 -9999.0 0.0 -0.395 6.0 6.0 cortical microtubule organization -0.007 0.072 -9999.0 0.0 -0.199 10.0 10.0 GO:0000145 -0.008 0.064 -9999.0 0.0 -0.176 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.005 0.074 -9999.0 0.0 -0.2 10.0 10.0 MLLT4 -0.001 0.067 -9999.0 0.0 -0.421 2.0 2.0 ARF6/GDP -0.023 0.061 -9999.0 0.0 -0.329 1.0 1.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.019 0.037 -9999.0 0.0 -0.214 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.065 -9999.0 0.0 -0.172 10.0 10.0 PVRL2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.068 -9999.0 0.0 -0.187 10.0 10.0 ARF6/GTP 0.021 0.035 -9999.0 0.0 -0.195 2.0 2.0 CDH1 -0.039 0.136 -9999.0 0.0 -0.421 9.0 9.0 EGFR/EGFR/EGF/EGF -0.025 0.086 -9999.0 0.0 -0.191 15.0 15.0 RhoA/GDP -0.005 0.068 -9999.0 0.0 -0.185 10.0 10.0 actin cytoskeleton organization -0.012 0.08 -9999.0 0.0 -0.195 12.0 12.0 IGF-1R heterotetramer 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.003 0.09 0.126 7.0 -0.421 3.0 10.0 DIAPH1 -0.064 0.216 -9999.0 0.0 -0.575 12.0 12.0 Wnt receptor signaling pathway 0.007 0.072 0.199 10.0 -9999.0 0.0 10.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.024 0.062 -9999.0 0.0 -0.329 1.0 1.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.012 0.081 -9999.0 0.0 -0.199 12.0 12.0 EFNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.004 0.065 -9999.0 0.0 -0.175 10.0 10.0 Ephrin A1/EPHA2 -0.024 0.061 -9999.0 0.0 -0.178 11.0 11.0 SEC6/SEC8 -0.025 0.065 -9999.0 0.0 -0.179 11.0 11.0 MGAT3 -0.004 0.09 -9999.0 0.0 -0.203 12.0 12.0 HGF/MET -0.04 0.09 -9999.0 0.0 -0.201 17.0 17.0 HGF -0.016 0.119 0.126 5.0 -0.421 6.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.017 0.092 -9999.0 0.0 -0.233 11.0 11.0 actin cable formation 0.002 0.078 -9999.0 0.0 -0.206 7.0 7.0 KIAA1543 -0.046 0.099 -9999.0 0.0 -0.185 26.0 26.0 KIFC3 -0.007 0.068 -9999.0 0.0 -0.187 10.0 10.0 NCK1 0.004 0.048 -9999.0 0.0 -0.421 1.0 1.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.007 0.068 -9999.0 0.0 -0.187 10.0 10.0 NCK1/GIT1 0.01 0.034 -9999.0 0.0 -0.293 1.0 1.0 mol:GDP -0.007 0.072 -9999.0 0.0 -0.199 10.0 10.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.007 0.068 -9999.0 0.0 -0.187 10.0 10.0 PIP5K1C -0.007 0.068 -9999.0 0.0 -0.187 10.0 10.0 LIMA1 -0.001 0.067 -9999.0 0.0 -0.421 2.0 2.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.004 0.064 -9999.0 0.0 -0.29 1.0 1.0 adherens junction assembly -0.045 0.107 -9999.0 0.0 -0.379 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.024 0.076 -9999.0 0.0 -0.194 12.0 12.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.007 0.048 -9999.0 0.0 -0.293 2.0 2.0 MET -0.007 0.082 -9999.0 0.0 -0.421 3.0 3.0 PLEKHA7 -0.006 0.069 -9999.0 0.0 -0.187 10.0 10.0 mol:GTP 0.018 0.037 -9999.0 0.0 -0.213 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.002 0.071 -9999.0 0.0 -0.33 1.0 1.0 cortical actin cytoskeleton stabilization -0.016 0.092 -9999.0 0.0 -0.231 11.0 11.0 regulation of cell-cell adhesion -0.012 0.08 -9999.0 0.0 -0.195 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.017 0.092 -9999.0 0.0 -0.233 11.0 11.0