Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCR signaling in naïve CD8+ T cells	21.0	1976.0	93.0	-0.188	0.017	1000.0	-1000.0	-0.031	-1000.0
IL12-mediated signaling events	16.0	1478.0	87.0	-0.363	0.086	1000.0	-1000.0	-0.074	-1000.0
Class IB PI3K non-lipid kinase events	15.0	45.0	3.0	-0.023	-1000.0	1000.0	-1000.0	-0.002	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1228.0	82.0	-0.084	0.022	1000.0	-1000.0	-0.039	-1000.0
Endothelins	12.0	1175.0	96.0	-0.143	0.027	1000.0	-1000.0	-0.026	-1000.0
Syndecan-1-mediated signaling events	10.0	365.0	34.0	-0.074	0.01	1000.0	-1000.0	-0.011	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	10.0	730.0	68.0	-0.215	0.06	1000.0	-1000.0	-0.044	-1000.0
Visual signal transduction: Rods	10.0	522.0	52.0	-0.048	0.022	1000.0	-1000.0	-0.018	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	164.0	17.0	-0.045	0.01	1000.0	-1000.0	-0.015	-1000.0
Ephrin B reverse signaling	9.0	452.0	48.0	-0.12	0.011	1000.0	-1000.0	-0.01	-1000.0
Ephrin A  reverse signaling	8.0	62.0	7.0	-0.042	0.002	1000.0	-1000.0	-0.001	-1000.0
HIF-1-alpha transcription factor network	8.0	677.0	76.0	-0.109	0.025	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-alpha and p38-beta	8.0	388.0	44.0	-0.087	0.01	1000.0	-1000.0	-0.013	-1000.0
LPA receptor mediated events	8.0	896.0	102.0	-0.093	0.01	1000.0	-1000.0	-0.035	-1000.0
IL23-mediated signaling events	8.0	526.0	60.0	-0.226	0.024	1000.0	-1000.0	-0.082	-1000.0
FOXM1 transcription factor network	8.0	413.0	51.0	-0.262	0.012	1000.0	-1000.0	-0.116	-1000.0
Syndecan-2-mediated signaling events	7.0	521.0	69.0	-0.059	0.01	1000.0	-1000.0	-0.013	-1000.0
a4b1 and a4b7 Integrin signaling	7.0	39.0	5.0	-0.006	0.004	1000.0	-1000.0	-0.001	-1000.0
Glucocorticoid receptor regulatory network	7.0	910.0	114.0	-0.407	0.169	1000.0	-1000.0	-0.031	-1000.0
TRAIL signaling pathway	7.0	351.0	48.0	-0.069	0.02	1000.0	-1000.0	-0.015	-1000.0
Glypican 2 network	7.0	28.0	4.0	-0.032	0.006	1000.0	-1000.0	0.0	-1000.0
IL2 signaling events mediated by STAT5	7.0	158.0	22.0	-0.148	0.012	1000.0	-1000.0	-0.012	-1000.0
BCR signaling pathway	7.0	765.0	99.0	-0.086	0.01	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	7.0	664.0	86.0	-0.086	0.081	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	551.0	78.0	-0.105	0.08	1000.0	-1000.0	-0.05	-1000.0
Caspase cascade in apoptosis	6.0	468.0	74.0	-0.025	0.021	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by the Hedgehog family	6.0	313.0	52.0	-0.067	0.011	1000.0	-1000.0	-0.015	-1000.0
PDGFR-alpha signaling pathway	6.0	270.0	44.0	-0.061	0.013	1000.0	-1000.0	-0.012	-1000.0
Reelin signaling pathway	6.0	368.0	56.0	-0.066	0.017	1000.0	-1000.0	-0.022	-1000.0
Wnt signaling	6.0	47.0	7.0	-0.028	0.009	1000.0	-1000.0	-0.003	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	488.0	74.0	-0.064	0.021	1000.0	-1000.0	-0.03	-1000.0
Syndecan-4-mediated signaling events	6.0	460.0	67.0	-0.058	0.013	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling events	6.0	30.0	5.0	-0.039	0.011	1000.0	-1000.0	-0.0	-1000.0
Osteopontin-mediated events	5.0	209.0	38.0	-0.093	0.014	1000.0	-1000.0	-0.029	-1000.0
Noncanonical Wnt signaling pathway	5.0	132.0	26.0	-0.028	0.01	1000.0	-1000.0	-0.012	-1000.0
p75(NTR)-mediated signaling	5.0	721.0	125.0	-0.061	0.028	1000.0	-1000.0	-0.035	-1000.0
BMP receptor signaling	5.0	432.0	81.0	-0.09	0.019	1000.0	-1000.0	-0.036	-1000.0
IL1-mediated signaling events	5.0	317.0	62.0	-0.048	0.028	1000.0	-1000.0	-0.027	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	247.0	45.0	-0.055	0.012	1000.0	-1000.0	-0.034	-1000.0
EPHB forward signaling	5.0	504.0	85.0	-0.041	0.034	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	397.0	76.0	-0.047	0.02	1000.0	-1000.0	-0.031	-1000.0
LPA4-mediated signaling events	4.0	58.0	12.0	-0.046	0.006	1000.0	-1000.0	-0.009	-1000.0
Visual signal transduction: Cones	4.0	179.0	38.0	-0.045	0.022	1000.0	-1000.0	-0.001	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	228.0	54.0	-0.066	0.017	1000.0	-1000.0	-0.033	-1000.0
Thromboxane A2 receptor signaling	4.0	483.0	105.0	-0.033	0.013	1000.0	-1000.0	-0.03	-1000.0
IL4-mediated signaling events	4.0	441.0	91.0	-0.16	0.033	1000.0	-1000.0	-0.124	-1000.0
amb2 Integrin signaling	4.0	329.0	82.0	-0.074	0.035	1000.0	-1000.0	-0.02	-1000.0
Nectin adhesion pathway	4.0	282.0	63.0	-0.039	0.013	1000.0	-1000.0	-0.031	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	246.0	52.0	-0.056	0.018	1000.0	-1000.0	-0.017	-1000.0
FAS signaling pathway (CD95)	4.0	208.0	47.0	-0.048	0.02	1000.0	-1000.0	-0.017	-1000.0
IL2 signaling events mediated by PI3K	4.0	243.0	58.0	-0.046	0.018	1000.0	-1000.0	-0.03	-1000.0
Integrins in angiogenesis	4.0	353.0	84.0	-0.095	0.022	1000.0	-1000.0	-0.032	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	144.0	31.0	-0.047	0.01	1000.0	-1000.0	-0.028	-1000.0
IL27-mediated signaling events	4.0	240.0	51.0	-0.134	0.039	1000.0	-1000.0	-0.024	-1000.0
Class I PI3K signaling events	4.0	323.0	73.0	-0.089	0.019	1000.0	-1000.0	-0.019	-1000.0
TCGA08_retinoblastoma	4.0	35.0	8.0	-0.015	0.008	1000.0	-1000.0	-0.003	-1000.0
EGFR-dependent Endothelin signaling events	4.0	96.0	21.0	-0.027	0.022	1000.0	-1000.0	-0.02	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	413.0	88.0	-0.083	0.022	1000.0	-1000.0	-0.06	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	525.0	120.0	-0.071	0.028	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling in keratinocytes	4.0	198.0	43.0	-0.039	0.012	1000.0	-1000.0	-0.011	-1000.0
Aurora B signaling	4.0	322.0	67.0	-0.093	0.011	1000.0	-1000.0	-0.018	-1000.0
BARD1 signaling events	3.0	208.0	57.0	-0.039	0.02	1000.0	-1000.0	-0.012	-1000.0
Cellular roles of Anthrax toxin	3.0	154.0	39.0	-0.015	0.01	1000.0	-1000.0	-0.008	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	311.0	85.0	-0.047	0.01	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PTP1B	3.0	245.0	76.0	-0.048	0.016	1000.0	-1000.0	-0.023	-1000.0
Aurora C signaling	3.0	24.0	7.0	-0.023	-0.0	1000.0	-1000.0	-0.005	-1000.0
Glypican 1 network	3.0	181.0	48.0	-0.032	0.014	1000.0	-1000.0	-0.01	-1000.0
PLK1 signaling events	3.0	303.0	85.0	-0.076	0.015	1000.0	-1000.0	-0.017	-1000.0
IFN-gamma pathway	3.0	207.0	68.0	-0.019	0.033	1000.0	-1000.0	-0.035	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	146.0	37.0	-0.01	0.018	1000.0	-1000.0	-0.01	-1000.0
S1P1 pathway	3.0	137.0	36.0	-0.075	0.012	1000.0	-1000.0	-0.024	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	49.0	15.0	-0.012	0.012	1000.0	-1000.0	-0.003	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	121.0	36.0	-0.02	0.021	1000.0	-1000.0	-0.017	-1000.0
Atypical NF-kappaB pathway	3.0	114.0	31.0	-0.048	0.016	1000.0	-1000.0	-0.006	-1000.0
Effects of Botulinum toxin	3.0	93.0	26.0	-0.026	0.015	1000.0	-1000.0	-0.01	-1000.0
Nongenotropic Androgen signaling	3.0	162.0	52.0	-0.029	0.013	1000.0	-1000.0	-0.015	-1000.0
Rapid glucocorticoid signaling	3.0	66.0	20.0	-0.058	0.01	1000.0	-1000.0	-0.002	-1000.0
p38 MAPK signaling pathway	3.0	150.0	44.0	-0.042	0.018	1000.0	-1000.0	-0.026	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	67.0	17.0	-0.011	0.015	1000.0	-1000.0	-0.009	-1000.0
ErbB2/ErbB3 signaling events	2.0	191.0	65.0	-0.024	0.018	1000.0	-1000.0	-0.022	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	348.0	136.0	-0.143	0.037	1000.0	-1000.0	-0.026	-1000.0
Coregulation of Androgen receptor activity	2.0	157.0	76.0	-0.054	0.027	1000.0	-1000.0	-0.014	-1000.0
ErbB4 signaling events	2.0	155.0	69.0	-0.053	0.033	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	59.0	28.0	-0.011	0.017	1000.0	-1000.0	-0.013	-1000.0
Arf6 signaling events	2.0	167.0	62.0	-0.037	0.019	1000.0	-1000.0	-0.02	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	135.0	65.0	-0.04	0.021	1000.0	-1000.0	-0.04	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	175.0	61.0	-0.068	0.029	1000.0	-1000.0	-0.022	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	256.0	97.0	-0.026	0.024	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class III	2.0	86.0	40.0	-0.05	0.037	1000.0	-1000.0	-0.008	-1000.0
S1P5 pathway	2.0	39.0	17.0	-0.008	0.012	1000.0	-1000.0	-0.006	-1000.0
TCGA08_p53	2.0	19.0	7.0	-0.005	0.009	1000.0	-1000.0	-0.005	-1000.0
Retinoic acid receptors-mediated signaling	2.0	131.0	58.0	-0.022	0.019	1000.0	-1000.0	-0.028	-1000.0
Syndecan-3-mediated signaling events	2.0	100.0	35.0	-0.113	0.028	1000.0	-1000.0	-0.013	-1000.0
Canonical Wnt signaling pathway	2.0	121.0	51.0	-0.068	0.046	1000.0	-1000.0	-0.03	-1000.0
Regulation of p38-alpha and p38-beta	2.0	140.0	54.0	-0.048	0.028	1000.0	-1000.0	-0.029	-1000.0
IL6-mediated signaling events	2.0	207.0	75.0	-0.035	0.033	1000.0	-1000.0	-0.03	-1000.0
IGF1 pathway	2.0	114.0	57.0	-0.016	0.023	1000.0	-1000.0	-0.03	-1000.0
VEGFR1 specific signals	2.0	113.0	56.0	-0.017	0.025	1000.0	-1000.0	-0.014	-1000.0
S1P3 pathway	2.0	96.0	42.0	-0.003	0.016	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by PRL	2.0	77.0	34.0	-0.025	0.014	1000.0	-1000.0	-0.011	-1000.0
S1P4 pathway	2.0	67.0	25.0	-0.004	0.014	1000.0	-1000.0	-0.013	-1000.0
Regulation of Androgen receptor activity	2.0	153.0	70.0	-0.047	0.028	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	1.0	106.0	75.0	-0.043	0.026	1000.0	-1000.0	-0.014	-1000.0
PLK2 and PLK4 events	1.0	5.0	3.0	-0.001	0.003	1000.0	-1000.0	-0.001	-1000.0
Aurora A signaling	1.0	91.0	60.0	-0.022	0.023	1000.0	-1000.0	-0.006	-1000.0
FOXA2 and FOXA3 transcription factor networks	1.0	52.0	46.0	-0.09	0.04	1000.0	-1000.0	-0.058	-1000.0
EPO signaling pathway	1.0	66.0	55.0	-0.008	0.042	1000.0	-1000.0	-0.03	-1000.0
Insulin-mediated glucose transport	1.0	62.0	32.0	-0.042	0.029	1000.0	-1000.0	-0.019	-1000.0
mTOR signaling pathway	1.0	66.0	53.0	-0.057	0.017	1000.0	-1000.0	-0.022	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	72.0	68.0	-0.041	0.028	1000.0	-1000.0	-0.011	-1000.0
Ceramide signaling pathway	1.0	90.0	76.0	-0.02	0.018	1000.0	-1000.0	-0.015	-1000.0
ceramide signaling pathway	1.0	76.0	49.0	-0.02	0.018	1000.0	-1000.0	-0.02	-1000.0
HIF-2-alpha transcription factor network	1.0	49.0	43.0	-0.112	0.114	1000.0	-1000.0	-0.04	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	134.0	83.0	-0.036	0.023	1000.0	-1000.0	-0.016	-1000.0
FoxO family signaling	1.0	96.0	64.0	-0.086	0.046	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	144.0	125.0	-0.017	0.03	1000.0	-1000.0	-0.034	-1000.0
TCGA08_rtk_signaling	1.0	41.0	26.0	-0.022	0.029	1000.0	-1000.0	-0.005	-1000.0
Regulation of Telomerase	1.0	151.0	102.0	-0.042	0.03	1000.0	-1000.0	-0.044	-1000.0
Insulin Pathway	1.0	105.0	74.0	-0.086	0.026	1000.0	-1000.0	-0.029	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	61.0	33.0	-0.035	0.02	1000.0	-1000.0	-0.013	-1000.0
PDGFR-beta signaling pathway	1.0	140.0	97.0	-0.075	0.027	1000.0	-1000.0	-0.024	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	0.004	0.027	1000.0	-1000.0	-0.011	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	30.0	34.0	-0.007	0.016	1000.0	-1000.0	-0.005	-1000.0
Canonical NF-kappaB pathway	0.0	24.0	39.0	-0.012	0.039	1000.0	-1000.0	-0.025	-1000.0
Circadian rhythm pathway	0.0	18.0	22.0	-0.014	0.021	1000.0	-1000.0	-0.024	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.025	0.026	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class I	0.0	73.0	104.0	-0.03	0.031	1000.0	-1000.0	-0.016	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	8.0	27.0	-0.004	0.025	1000.0	-1000.0	-0.019	-1000.0
Arf6 trafficking events	0.0	20.0	71.0	-0.018	0.02	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	0.0	10.0	54.0	-0.007	0.017	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.028	1000.0	-1000.0	-0.001	-1000.0
Total	524	33477	7203	-7.80889773793	-996.926122069	131000	-131000	-2.99013101549	-131000