E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.086 0.151 -9999.0 0.0 -0.31 24.0 24.0 KLHL20 -0.022 0.065 -9999.0 0.0 -0.229 1.0 1.0 CYFIP2 -0.013 0.115 0.237 2.0 -0.29 11.0 13.0 Rac1/GDP -0.051 0.093 -9999.0 0.0 -0.237 8.0 8.0 ENAH -0.088 0.15 -9999.0 0.0 -0.312 23.0 23.0 AP1M1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.036 -9999.0 0.0 -0.29 1.0 1.0 CDC42/GTP -0.044 0.05 -9999.0 0.0 -0.186 2.0 2.0 ABI1/Sra1/Nap1 -0.037 0.042 -9999.0 0.0 -0.122 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.021 0.079 0.19 1.0 -0.161 11.0 12.0 RAPGEF1 -0.092 0.137 -9999.0 0.0 -0.286 24.0 24.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.081 0.159 -9999.0 0.0 -0.31 25.0 25.0 CRK -0.09 0.148 -9999.0 0.0 -0.298 25.0 25.0 E-cadherin/gamma catenin/alpha catenin 0.03 0.059 -9999.0 0.0 -0.171 6.0 6.0 alphaE/beta7 Integrin 0.03 0.049 0.184 1.0 -0.203 3.0 4.0 IQGAP1 0.009 0.069 -9999.0 0.0 -0.29 4.0 4.0 NCKAP1 0.021 0.035 -9999.0 0.0 -0.29 1.0 1.0 Rap1/GTP/I-afadin 0.032 0.037 -9999.0 0.0 -0.156 2.0 2.0 DLG1 -0.056 0.139 -9999.0 0.0 -0.351 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.045 0.036 -9999.0 0.0 -0.135 8.0 8.0 MLLT4 0.014 0.049 -9999.0 0.0 -0.29 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.048 0.039 0.173 4.0 -0.156 1.0 5.0 PI3K -0.056 0.046 -9999.0 0.0 -0.17 8.0 8.0 ARF6 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.017 0.063 -9999.0 0.0 -0.2 6.0 6.0 TIAM1 0.03 0.059 0.237 4.0 -0.29 1.0 5.0 E-cadherin(dimer)/Ca2+ 0.023 0.064 -9999.0 0.0 -0.149 8.0 8.0 AKT1 -0.036 0.033 -9999.0 0.0 -0.163 1.0 1.0 PIK3R1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.004 0.089 -9999.0 0.0 -0.29 7.0 7.0 RhoA/GDP -0.052 0.091 -9999.0 0.0 -0.237 8.0 8.0 actin cytoskeleton organization -0.016 0.05 -9999.0 0.0 -0.167 1.0 1.0 CDC42/GDP -0.051 0.092 -9999.0 0.0 -0.237 8.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.004 0.057 -9999.0 0.0 -0.186 7.0 7.0 ITGB7 0.016 0.065 0.237 1.0 -0.29 3.0 4.0 RAC1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.027 0.068 -9999.0 0.0 -0.16 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.016 0.056 -9999.0 0.0 -0.143 8.0 8.0 mol:GDP -0.066 0.098 -9999.0 0.0 -0.267 8.0 8.0 CDC42/GTP/IQGAP1 0.02 0.044 -9999.0 0.0 -0.164 4.0 4.0 JUP 0.028 0.024 0.237 1.0 -9999.0 0.0 1.0 p120 catenin/RhoA/GDP -0.046 0.097 -9999.0 0.0 -0.24 8.0 8.0 RAC1/GTP/IQGAP1 0.023 0.044 -9999.0 0.0 -0.167 4.0 4.0 PIP5K1C/AP1M1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.033 -9999.0 0.0 -9999.0 0.0 0.0 NME1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.085 0.151 -9999.0 0.0 -0.312 23.0 23.0 regulation of cell-cell adhesion -0.043 0.038 -9999.0 0.0 -0.145 8.0 8.0 WASF2 -0.015 0.027 -9999.0 0.0 -0.082 4.0 4.0 Rap1/GTP -0.045 0.058 -9999.0 0.0 -0.23 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.042 0.077 -9999.0 0.0 -0.155 9.0 9.0 CCND1 -0.012 0.04 -9999.0 0.0 -9999.0 0.0 0.0 VAV2 -0.076 0.153 -9999.0 0.0 -0.358 9.0 9.0 RAP1/GDP -0.033 0.078 -9999.0 0.0 -0.217 3.0 3.0 adherens junction assembly -0.082 0.147 -9999.0 0.0 -0.303 23.0 23.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.01 0.07 -9999.0 0.0 -0.153 10.0 10.0 E-cadherin/beta catenin -0.015 0.076 -9999.0 0.0 -0.258 7.0 7.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.088 0.151 -9999.0 0.0 -0.307 25.0 25.0 PIK3CA 0.013 0.049 -9999.0 0.0 -0.29 2.0 2.0 Rac1/GTP -0.041 0.08 -9999.0 0.0 -0.235 2.0 2.0 E-cadherin/beta catenin/alpha catenin 0.017 0.067 -9999.0 0.0 -0.172 8.0 8.0 ITGAE 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.082 0.162 -9999.0 0.0 -0.316 25.0 25.0