Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.03 0.083 -9999.0 0.0 -0.208 9.0 9.0 epithelial cell differentiation 0.02 0.062 -9999.0 0.0 -0.148 8.0 8.0 CYFIP2 -0.013 0.115 0.237 2.0 -0.29 11.0 13.0 ENAH -0.045 0.042 -9999.0 0.0 -0.199 1.0 1.0 EGFR 0.029 0.054 0.237 3.0 -0.29 1.0 4.0 EPHA2 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.032 0.048 0.169 1.0 -0.255 1.0 2.0 CTNNB1 0.017 0.036 -9999.0 0.0 -0.29 1.0 1.0 ABI1/Sra1/Nap1 0.021 0.084 0.183 2.0 -0.173 12.0 14.0 AQP5 -0.053 0.125 -9999.0 0.0 -0.4 8.0 8.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.033 0.043 0.168 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.067 -9999.0 0.0 -9999.0 0.0 0.0 EGF 0.045 0.111 0.237 14.0 -0.29 4.0 18.0 NCKAP1 0.021 0.035 -9999.0 0.0 -0.29 1.0 1.0 AQP3 -0.042 0.119 -9999.0 0.0 -0.384 7.0 7.0 cortical microtubule organization 0.02 0.062 -9999.0 0.0 -0.148 8.0 8.0 GO:0000145 -0.031 0.041 0.161 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.023 0.064 -9999.0 0.0 -0.149 8.0 8.0 MLLT4 0.014 0.049 -9999.0 0.0 -0.29 2.0 2.0 ARF6/GDP -0.048 0.041 -9999.0 0.0 -0.16 8.0 8.0 ARF6 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.049 0.036 -9999.0 0.0 -0.161 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.024 0.045 0.165 1.0 -9999.0 0.0 1.0 PVRL2 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.033 0.044 0.169 1.0 -9999.0 0.0 1.0 ARF6/GTP 0.052 0.04 -9999.0 0.0 -0.154 1.0 1.0 CDH1 -0.004 0.089 -9999.0 0.0 -0.29 7.0 7.0 EGFR/EGFR/EGF/EGF 0.02 0.083 0.208 1.0 -0.159 10.0 11.0 RhoA/GDP 0.021 0.061 -9999.0 0.0 -0.145 8.0 8.0 actin cytoskeleton organization -0.039 0.049 0.15 1.0 -0.255 1.0 2.0 IGF-1R heterotetramer 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.032 0.087 0.237 7.0 -0.29 3.0 10.0 DIAPH1 -0.047 0.235 -9999.0 0.0 -0.573 13.0 13.0 Wnt receptor signaling pathway -0.02 0.062 0.148 8.0 -9999.0 0.0 8.0 RHOA 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.046 0.042 -9999.0 0.0 -0.161 8.0 8.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.04 0.05 0.151 1.0 -0.261 1.0 2.0 EFNA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.034 0.044 0.164 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 0.014 0.06 -9999.0 0.0 -0.147 8.0 8.0 SEC6/SEC8 -0.045 0.038 -9999.0 0.0 -0.148 9.0 9.0 MGAT3 -0.015 0.068 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET 0.004 0.081 -9999.0 0.0 -0.153 14.0 14.0 HGF 0.014 0.101 0.237 5.0 -0.29 6.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.03 0.083 -9999.0 0.0 -0.209 9.0 9.0 actin cable formation -0.035 0.069 -9999.0 0.0 -0.3 2.0 2.0 KIAA1543 -0.032 0.038 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.035 0.038 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.017 0.036 -9999.0 0.0 -0.29 1.0 1.0 EXOC3 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.033 0.044 0.169 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.028 0.03 -9999.0 0.0 -0.203 1.0 1.0 mol:GDP 0.02 0.062 -9999.0 0.0 -0.148 8.0 8.0 EXOC4 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.035 0.038 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.033 0.044 0.169 1.0 -9999.0 0.0 1.0 LIMA1 0.017 0.049 -9999.0 0.0 -0.29 2.0 2.0 ABI1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.042 0.05 -9999.0 0.0 -0.224 1.0 1.0 adherens junction assembly -0.035 0.056 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 0.015 0.077 -9999.0 0.0 -0.159 10.0 10.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.026 0.039 -9999.0 0.0 -0.203 2.0 2.0 MET 0.013 0.06 -9999.0 0.0 -0.29 3.0 3.0 PLEKHA7 -0.033 0.042 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.047 0.035 -9999.0 0.0 -0.161 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.043 0.051 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.03 0.083 -9999.0 0.0 -0.208 9.0 9.0 regulation of cell-cell adhesion -0.039 0.049 0.15 1.0 -0.255 1.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.03 0.083 -9999.0 0.0 -0.209 9.0 9.0