		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	364 (71%)	147	9.9999e-06	0.00031	9.9999e-06	0.00031	0.1419	0.456	0.74814	0.941	9.9999e-06	0.00031	9.9999e-06	0.00031	9.9999e-06	0.00031	9.9999e-06	0.00031	0.00161	0.0256	9.9999e-06	0.00031
CDKN2A	112 (22%)	399	4e-05	0.00108	9.9999e-06	0.00031	0.01055	0.109	0.81355	0.976	0.086259	0.332	9.9999e-06	0.00031	0.0452	0.252	0.04215	0.24	0.90839	1	0.01532	0.14
NSD1	62 (12%)	449	0.0072199	0.0915	9.9999e-06	0.00031	0.0072899	0.0915	0.01435	0.135	9.9999e-06	0.00031	9.9999e-06	0.00031	0.00251	0.038	0.00013	0.00322	0.21907	0.597	0.00012	0.0031
CASP8	54 (11%)	457	9.9999e-06	0.00031	9.9999e-06	0.00031	0.087709	0.336	0.34959	0.699	9.9999e-06	0.00031	9.9999e-06	0.00031	9.9999e-06	0.00031	0.57057	0.857	0.11177	0.396	0.01077	0.109
MLL2	81 (16%)	430	0.17998	0.547	0.02241	0.169	0.65282	0.905	0.51967	0.826	0.21435	0.595	0.29034	0.666	0.24611	0.623	0.052579	0.276	0.54338	0.841	0.11309	0.398
TGFBR2	24 (5%)	487	0.00161	0.0256	0.02896	0.195	0.56359	0.856	0.90108	0.999	0.43662	0.763	0.95252	1	0.30722	0.671	0.78127	0.963	0.43622	0.763	0.41731	0.75
HLA-B	24 (5%)	487	0.00273	0.0403	0.0084399	0.0987	0.8521	0.986	0.22444	0.597	0.0263	0.182	0.070219	0.311	0.069649	0.311	0.19399	0.553	0.0068399	0.0902	0.04645	0.255
FBXW7	33 (6%)	478	0.061179	0.299	0.058299	0.296	0.1821	0.55	0.23233	0.608	0.097909	0.361	0.44277	0.768	0.47611	0.789	0.52276	0.827	0.10438	0.381	0.42167	0.75
NOTCH1	90 (18%)	421	0.03433	0.22	2e-05	0.000564	0.30752	0.671	0.059169	0.296	0.00028	0.00599	0.00319	0.046	0.00017	0.00405	0.078909	0.328	0.068559	0.308	0.01182	0.115
FAT1	112 (22%)	399	0.0301	0.199	9.9999e-06	0.00031	0.92462	1	0.48782	0.803	0.01859	0.154	0.00071999	0.0131	0.02637	0.182	0.59212	0.87	0.25074	0.627	0.26903	0.654
JUB	34 (7%)	477	0.89389	0.995	0.4003	0.735	0.085339	0.332	0.63745	0.904	0.11938	0.409	0.77182	0.954	0.0298	0.199	0.35486	0.705	0.32069	0.684	0.39319	0.73
ZNF750	21 (4%)	490	0.19017	0.553	0.01623	0.144	0.62317	0.897	0.28545	0.666	0.03793	0.228	0.0083199	0.0987	0.00026	0.00576	0.21529	0.595	1	1	0.19856	0.557
NFE2L2	27 (5%)	484	0.54059	0.841	2e-05	0.000564	0.083149	0.332	0.87431	0.986	0.91172	1	0.28439	0.666	0.096429	0.358	0.34277	0.694	0.81747	0.976	0.63262	0.902
HLA-A	22 (4%)	489	0.00067999	0.0128	0.0182	0.154	0.96391	1	0.63976	0.905	0.03925	0.232	0.00065999	0.0128	0.30688	0.671	0.03106	0.203	0.317	0.683	0.02158	0.169
EPHA2	24 (5%)	487	0.32375	0.687	0.00026	0.00576	0.97176	1	0.93022	1	0.37356	0.722	0.31737	0.683	0.66145	0.906	0.18885	0.553	0.43798	0.763	0.32109	0.684
RAC1	15 (3%)	496	0.0039	0.0537	0.03638	0.226	0.70504	0.925	0.83423	0.976	0.00389	0.0537	0.078409	0.328	1	1	0.34396	0.695	0.46249	0.781	0.58518	0.864
HRAS	31 (6%)	480	9.9999e-06	0.00031	9.9999e-06	0.00031	0.57683	0.858	0.65093	0.905	0.00050999	0.0102	0.02536	0.181	0.00043	0.00889	0.10916	0.391	0.57031	0.857	0.49081	0.803
EP300	38 (7%)	473	0.03699	0.227	0.01651	0.144	0.39547	0.73	0.085109	0.332	0.055669	0.29	0.059859	0.297	0.31268	0.678	0.04214	0.24	0.42925	0.758	0.23532	0.61
OR6C65	16 (3%)	495	0.96304	1	0.27341	0.657	0.64467	0.905	0.4321	0.759	0.67758	0.91	0.74759	0.941	0.04152	0.24	0.6949	0.919	0.077389	0.327	0.91535	1
PIK3CA	94 (18%)	417	0.058819	0.296	0.15931	0.504	0.98276	1	0.062769	0.299	0.092089	0.348	0.32921	0.69	0.090149	0.343	0.02295	0.169	0.093229	0.35	0.1936	0.553
PTEN	14 (3%)	497	0.78933	0.969	0.13078	0.434	0.4042	0.739	0.83392	0.976	0.66167	0.906	0.23171	0.608	0.59069	0.87	0.22402	0.597	0.74426	0.94	0.079369	0.328
RASA1	18 (4%)	493	0.3755	0.722	0.18884	0.553	0.18458	0.55	0.7128	0.928	0.2168	0.595	0.20526	0.573	0.87241	0.986	0.62654	0.897	0.47517	0.789	0.67946	0.91
MAPK1	9 (2%)	502	0.0115	0.113	0.62325	0.897	0.60192	0.882	0.83251	0.976	0.70599	0.925	0.91893	1	0.19245	0.553	0.83606	0.976	0.83972	0.976	0.16851	0.525
NUDT11	9 (2%)	502	0.88977	0.992	0.6111	0.889	0.36377	0.711	0.73296	0.934	0.90982	1	0.6786	0.91	0.80873	0.976	0.40083	0.735	0.88892	0.992	0.79233	0.969
KDM6A	17 (3%)	494	0.18997	0.553	0.37601	0.722	0.04434	0.25	1	1	0.92939	1	0.36273	0.711	0.65126	0.905	0.90722	1	0.40668	0.739	0.33061	0.69
RB1	17 (3%)	494	0.33657	0.693	0.19662	0.557	0.23836	0.616	0.27321	0.657	0.01855	0.154	0.2529	0.627	0.10076	0.37	0.26407	0.645	0.13158	0.434	0.30368	0.671
KEAP1	22 (4%)	489	0.41936	0.75	0.13178	0.434	0.76644	0.952	0.8269	0.976	0.33169	0.69	0.00106	0.0178	0.7869	0.968	0.04113	0.24	0.36984	0.719	0.31844	0.683
KRT17	6 (1%)	505	0.93167	1	0.29445	0.666	0.30342	0.671	0.65511	0.905	0.77239	0.954	0.29386	0.666	0.97375	1	0.88108	0.99	0.061189	0.299	1	1
RHOA	10 (2%)	501	0.30084	0.671	0.64782	0.905	0.39496	0.73	0.24196	0.617	1	1	1	1	0.86834	0.986	0.56491	0.856	0.73309	0.934	0.65832	0.906
PTPN14	16 (3%)	495	0.4514	0.771	0.02772	0.189	0.19818	0.557	0.57889	0.859	0.36002	0.711	0.66938	0.906	0.03471	0.22	0.50242	0.813	0.03782	0.228	0.29414	0.666
KRTAP5-5	4 (1%)	507	0.64206	0.905	0.91823	1	1	1	0.79521	0.969	0.01454	0.135	0.54682	0.841	0.01062	0.109	0.26041	0.638	1	1	0.35432	0.705
ZNF623	12 (2%)	499	0.71956	0.931	0.6647	0.906	0.23982	0.617	0.34027	0.694	0.83037	0.976	0.10773	0.391	0.82186	0.976	0.057819	0.296	0.8831	0.99	0.073069	0.319
TIGD4	7 (1%)	504	0.65498	0.905	0.93848	1	0.81598	0.976	0.83504	0.976	0.50353	0.813	0.39141	0.73	0.85603	0.986	0.39489	0.73	0.5762	0.858	0.53918	0.841
NAP1L2	7 (1%)	504	0.94428	1	0.062709	0.299	0.51391	0.82	1	1	0.3952	0.73	0.44784	0.769	0.97652	1	0.5677	0.857	0.30759	0.671	0.88889	0.992
CUL3	16 (3%)	495	0.03478	0.22	0.01006	0.108	0.5079	0.815	0.73269	0.934	0.27523	0.659	0.01933	0.158	0.04626	0.255	0.90227	0.999	0.46353	0.781	0.4474	0.769
CREBBP	34 (7%)	477	0.11615	0.405	0.45058	0.771	0.3052	0.671	0.93223	1	0.085199	0.332	0.073939	0.321	0.71207	0.928	0.02321	0.169	0.1206	0.409	0.01146	0.113
VEZF1	8 (2%)	503	0.44368	0.768	0.050589	0.268	0.96386	1	0.058769	0.296	0.86312	0.986	0.49449	0.803	0.02274	0.169	0.26031	0.638	0.27925	0.664	0.63115	0.902
MLL4	19 (4%)	492	0.00096999	0.0167	0.00174	0.027	0.8322	0.976	0.38242	0.727	0.12539	0.42	0.1695	0.525	0.02059	0.164	0.91542	1	0.12268	0.413	0.62575	0.897
IRS4	17 (3%)	494	0.0198	0.159	0.55174	0.847	0.19458	0.553	0.79081	0.969	0.40916	0.742	0.065929	0.303	0.54646	0.841	0.050009	0.267	0.03525	0.221	0.13233	0.434
HUWE1	46 (9%)	465	0.0089799	0.101	0.00081999	0.0145	0.72818	0.934	0.63657	0.904	0.23427	0.61	0.080529	0.329	0.74327	0.94	0.46236	0.781	0.70981	0.928	0.61726	0.894
THSD7A	32 (6%)	479	0.68582	0.912	0.12049	0.409	0.47079	0.788	0.24913	0.627	0.00497	0.067	0.065679	0.303	0.27002	0.654	0.03846	0.229	0.080669	0.329	0.0232	0.169
C3ORF59	10 (2%)	501	0.51429	0.82	0.34546	0.695	NA	NA	NA	NA	0.83368	0.976	0.55777	0.854	0.9891	1	0.72437	0.934	1	1	0.37844	0.724
DYSF	20 (4%)	491	0.64675	0.905	0.0096999	0.106	0.56048	0.855	0.73224	0.934	0.19415	0.553	0.0090999	0.101	0.60588	0.885	0.21939	0.597	0.29341	0.666	0.16089	0.504
ZNF233	9 (2%)	502	0.73357	0.934	0.38123	0.727	0.29739	0.668	0.28697	0.666	0.33904	0.694	1	1	0.18271	0.55	0.64087	0.905	0.17533	0.535	0.28542	0.666
KIAA1267	11 (2%)	500	0.0073799	0.0915	0.66822	0.906	0.085639	0.332	0.062079	0.299	0.97467	1	1	1	0.39124	0.73	0.92727	1	0.4714	0.788	0.67666	0.91
ASXL1	16 (3%)	495	0.62337	0.897	0.98471	1	0.21611	0.595	0.87341	0.986	0.076439	0.327	0.01766	0.152	0.066529	0.303	0.065609	0.303	0.56153	0.855	0.077639	0.327
SMAD4	13 (3%)	498	0.25	0.627	0.34614	0.695	0.11991	0.409	0.87405	0.986	0.33987	0.694	0.56832	0.857	0.18456	0.55	0.49449	0.803	0.50858	0.815	0.23207	0.608
GAGE2A	4 (1%)	507	0.0086199	0.099	0.094829	0.354	0.46967	0.788	0.79422	0.969	0.84023	0.976	0.48446	0.801	0.17364	0.533	0.685	0.912	1	1	1	1
EMG1	3 (1%)	508	0.84103	0.976	0.86892	0.986	NA	NA	NA	NA	0.22426	0.597	0.74125	0.94	0.52868	0.832	1	1	NA	NA	NA	NA
PIK3R1	8 (2%)	503	0.86962	0.986	0.3316	0.69	NA	NA	NA	NA	0.070909	0.312	0.11147	0.396	0.3953	0.73	0.29421	0.666	1	1	0.34175	0.694
KRTAP5-7	5 (1%)	506	0.83528	0.976	0.93707	1	NA	NA	NA	NA	0.68751	0.913	0.24184	0.617	0.66419	0.906	0.02304	0.169	0.69517	0.919	0.54676	0.841
SLC9A6	5 (1%)	506	0.13483	0.44	0.081819	0.332	1	1	0.11458	0.401	0.02636	0.182	0.36519	0.712	0.4223	0.75	0.22942	0.608	0.52267	0.827	0.075739	0.326
ELF4	7 (1%)	504	0.76985	0.954	0.7968	0.969	0.2968	0.668	0.33577	0.693	0.87587	0.986	0.86034	0.986	0.14518	0.464	0.80185	0.973	0.39109	0.73	0.61625	0.894
CTCF	15 (3%)	496	0.0122	0.116	0.0076899	0.0935	0.90204	0.999	0.52638	0.83	0.60698	0.885	0.41183	0.744	0.6968	0.919	0.71682	0.93	1	1	0.7161	0.93
HNRNPL	11 (2%)	500	0.4579	0.778	0.28048	0.664	0.37488	0.722	0.45609	0.777	0.6617	0.906	0.33362	0.692	0.15112	0.48	0.01561	0.14	0.29205	0.666	0.65465	0.905
ZFP36L2	8 (2%)	503	0.22285	0.597	0.04814	0.262	0.70553	0.925	0.35624	0.706	0.86409	0.986	0.49388	0.803	0.41573	0.749	0.67768	0.91	1	1	0.75796	0.944
MYH9	21 (4%)	490	0.25211	0.627	0.36327	0.711	0.066509	0.303	0.75257	0.943	0.93053	1	0.74222	0.94	0.82233	0.976	0.40499	0.739	0.58111	0.86	0.7543	0.943
NOTCH2	21 (4%)	490	0.92368	1	0.98347	1	0.02396	0.173	0.48806	0.803	0.24341	0.618	0.44731	0.769	0.57384	0.858	0.66766	0.906	0.75653	0.944	0.39039	0.73
NCOR1	17 (3%)	494	0.86814	0.986	0.42081	0.75	0.47584	0.789	0.49405	0.803	0.8177	0.976	0.25405	0.628	0.82488	0.976	0.22233	0.597	0.86751	0.986	0.81286	0.976
AK5	13 (3%)	498	0.75358	0.943	0.28021	0.664	0.426	0.755	0.54505	0.841	0.84739	0.982	0.57473	0.858	0.04978	0.267	0.085149	0.332	0.17051	0.526	0.082429	0.332
SPTY2D1	10 (2%)	501	0.10907	0.391	0.13628	0.442	0.065039	0.303	0.28597	0.666	0.32575	0.689	0.8584	0.986	0.32678	0.689	0.30991	0.674	0.50522	0.814	0.54318	0.841
PIWIL2	8 (2%)	503	0.73143	0.934	0.11884	0.409	0.81989	0.976	0.68248	0.912	0.18539	0.55	0.53237	0.836	0.13997	0.452	0.068469	0.308	0.43049	0.758	0.16013	0.504
