rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(7)	395753	7	7	7	0	1	2	0	4	0	0	0.187	0.000579	0.356
2	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(6), GREB1(12), HSPB1(1), HSPB2(1), MTA1(6), PDZK1(4), TUBA8(2)	6506963	33	32	31	2	3	13	6	7	4	0	0.000993	0.00231	0.711
3	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(3), CFL1(1), GNAQ(1), GNAS(10), GNB1(2), LIMK1(4), MAPK1(3), NOX1(3), PIK3C2G(7), PLCB1(8), PPP1R12B(4), PRKCA(1), PTK2(9), RAF1(2), ROCK2(3)	14537713	62	52	59	2	7	16	7	22	10	0	2.34e-05	0.00982	1.000
4	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), LPO(4), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TPO(13), TYR(5)	5528691	34	31	34	3	2	6	8	11	7	0	0.00756	0.00984	1.000
5	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), ATP6V0C(2), CAT(1), EPX(3), LPO(4), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), SHMT1(2), SHMT2(4), TPO(13)	6710725	40	34	40	3	2	9	6	11	12	0	0.00588	0.0169	1.000
6	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(1), GNB1(2), HTR2C(3), PLCB1(8), TUB(3)	3981712	20	18	20	1	1	3	2	6	8	0	0.0640	0.0270	1.000
7	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), PTK2B(5), SHC1(3), SOS1(8), SRC(3)	4901533	20	20	20	1	2	6	4	4	3	1	0.0183	0.0302	1.000
8	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB10(2), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMB9(1)	4919552	23	21	23	1	0	7	4	8	4	0	0.0137	0.0372	1.000
9	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IFNG(3), IL12A(6), IL12B(2), IL18(2)	1718224	13	12	13	2	0	1	3	7	2	0	0.339	0.0375	1.000
10	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(11), PDXK(1), PNPO(1), PSAT1(2)	2699768	15	13	15	1	0	8	1	3	3	0	0.0723	0.0463	1.000
11	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(1), EPX(3), LPO(4), MPO(5), MTHFR(1), PRDX6(1), SHMT1(2), SHMT2(4), TPO(13)	6517697	36	30	36	3	2	9	7	9	9	0	0.00661	0.0497	1.000
12	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR0B2(4), NR1H3(4), NR1H4(5), RXRA(2)	2992040	17	15	16	1	1	0	5	8	3	0	0.0567	0.0732	1.000
13	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(2), NTRK1(5), PIK3R1(4), PLCG1(7), PRKCA(1), SHC1(3), SOS1(8)	7594929	30	26	29	2	3	6	5	4	11	1	0.0128	0.0927	1.000
14	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(3), CCNA2(4), CCND1(1), CCNE1(1), CCNE2(2), CDKN1B(5), E2F1(3), E2F4(2)	4837877	21	19	18	1	0	4	2	12	3	0	0.0243	0.102	1.000
15	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(4), PLCB1(8), PLCG1(7), PRKCA(1), VAV1(3)	6025453	25	22	24	1	0	7	1	6	11	0	0.0234	0.103	1.000
16	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(3), CYP11A1(1), CYP11B1(4), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2)	5118543	21	20	21	2	5	4	2	7	3	0	0.0533	0.106	1.000
17	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(3), CYP11A1(1), CYP11B1(4), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2)	5118543	21	20	21	2	5	4	2	7	3	0	0.0533	0.106	1.000
18	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(4), SNAP25(3), STX1A(1)	1758176	11	11	10	2	1	3	1	4	2	0	0.486	0.111	1.000
19	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), LPO(4), MPO(5), PRDX6(1), TPO(13)	4778378	26	23	26	3	2	5	6	8	5	0	0.0286	0.113	1.000
20	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(9), JUND(1), PPP1R1B(1)	2130336	12	12	11	3	2	1	4	4	1	0	0.345	0.115	1.000
21	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(1), GLUD1(3), GLUD2(5)	2564143	13	12	13	1	0	5	4	2	2	0	0.0781	0.126	1.000
22	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(3), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(1), IL5(1), IL5RA(1), IL6(2)	2949224	13	12	13	1	1	0	1	10	1	0	0.186	0.129	1.000
23	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(2), BCAR1(3), CDKN1B(5), MAPK1(3), PDK2(1), PDPK1(1), PIK3R1(4), PTK2(9), SHC1(3), SOS1(8)	9466625	39	30	38	0	2	9	6	8	13	1	1.97e-05	0.130	1.000
24	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(1), COQ5(1), COQ6(4), COQ7(1)	2441218	9	9	9	1	1	1	2	3	2	0	0.285	0.169	1.000
25	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	GSTZ1(2), HGD(4)	1238975	6	6	6	0	0	1	0	4	1	0	0.364	0.175	1.000
26	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	280438	2	2	2	0	0	0	0	1	1	0	0.858	0.188	1.000
27	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(7), PRKCA(1), PTK2B(5)	3741191	14	14	13	1	0	5	0	4	5	0	0.259	0.191	1.000
28	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(2), IGF1R(11), IRS1(3), MAPK1(3), PIK3R1(4), RAF1(2), SHC1(3), SOS1(8)	9334515	36	30	36	2	3	6	8	9	9	1	0.00241	0.213	1.000
29	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3)	6067489	28	25	26	3	2	3	3	13	7	0	0.0429	0.219	1.000
30	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(3), CASP8(1), CFL1(1), CFLAR(2)	2141634	8	7	8	1	0	2	1	2	3	0	0.390	0.220	1.000
31	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(4), FH(3), IDH2(4), MDH1(1), OGDH(1), SDHA(2), SUCLA2(2)	5334258	20	18	20	2	1	4	2	6	7	0	0.115	0.223	1.000
32	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	19	CCNA1(3), CCNB1(2), CCND1(1), CCND2(3), CCNE1(1), CCNH(1), CDK6(1), CDKN1B(5), CDKN2B(1), CDKN2C(2), E2F1(3), RBL1(4), TFDP1(2)	7628055	29	27	28	2	1	5	5	11	7	0	0.00912	0.246	1.000
33	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MYC(2), SP1(2), SP3(3), WT1(6)	3569199	13	13	13	2	2	2	3	4	2	0	0.197	0.256	1.000
34	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), CD80(4), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL4(1)	2204585	9	9	9	2	0	2	1	5	1	0	0.480	0.260	1.000
35	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(2), AKT2(3), AKT3(2), MAP2K2(2), NGFR(3), NTRK1(5), PIK3CD(5), SHC1(3), SOS1(8)	8086842	33	31	33	4	4	10	6	5	7	1	0.0366	0.274	1.000
36	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(3), HLA-DRA(1), HLA-DRB1(1), IL5(1)	1633362	7	7	7	0	1	0	0	6	0	0	0.214	0.313	1.000
37	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), AKT2(3), AKT3(2), BPNT1(2), MAPK1(3), PDK1(1), PIK3CD(5), PTK2B(5), RBL2(11), SHC1(3), SOS1(8)	9715167	45	41	45	5	3	13	7	9	12	1	0.0184	0.314	1.000
38	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(6), CAPN1(2), CAPNS1(1), CSNK1A1(2), GSK3B(3), MAPT(6), PPP2CA(2)	5532449	22	21	22	1	1	8	0	6	7	0	0.0335	0.320	1.000
39	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(1), CDKN1B(5), CKS1B(2), CUL1(2), E2F1(3), SKP2(1), TFDP1(2)	3835157	16	15	15	2	0	1	3	5	7	0	0.210	0.321	1.000
40	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(2), CBS(3), CTH(2), MUT(4)	2794156	11	10	11	1	1	4	0	2	4	0	0.257	0.331	1.000
41	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(1), NR3C1(3), PPARG(1), RXRA(2), TNF(1)	3219049	10	10	9	1	0	0	2	5	3	0	0.381	0.332	1.000
42	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(2), FOS(1), JUN(2), MAPK8(1), NGFR(3), PIK3R1(4), PLCG1(7), RAF1(2), SHC1(3), SOS1(8)	9564697	33	29	32	2	2	6	5	7	12	1	0.00863	0.334	1.000
43	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(2), PSMD1(7), PSMD11(1), PSMD12(7), PSMD13(2), PSMD2(2), PSMD6(1)	9003610	42	35	42	5	1	14	5	15	7	0	0.0163	0.343	1.000
44	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(1), CPS1(12), GLS(4), GLUD1(3)	4373737	21	18	21	4	1	8	3	4	5	0	0.232	0.346	1.000
45	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(5), ERBB4(11), NRG2(1), NRG3(3), PRKCA(1), PSEN1(2)	5099442	23	22	22	4	1	4	1	14	3	0	0.318	0.363	1.000
46	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(9), ATR(15), CDC25C(3), CHEK1(5), CHEK2(5)	8369196	37	32	37	4	3	3	2	19	9	1	0.144	0.396	1.000
47	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(2), GGT1(1), SHMT1(2), SHMT2(4)	2446983	9	9	9	0	1	4	0	2	2	0	0.0923	0.400	1.000
48	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2)	3872882	14	13	14	2	4	2	1	4	3	0	0.195	0.402	1.000
49	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(9), ARHGAP5(3), CASP10(2), CASP3(3), CASP8(1), CASP9(1), GZMB(2), JUN(2), PRF1(4)	7106840	27	23	27	2	1	10	2	7	7	0	0.0410	0.406	1.000
50	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB1A(2), RAB27A(1), RAB4A(2), RAB6A(2), RAB9A(1)	2410361	9	8	9	1	0	3	1	2	3	0	0.400	0.436	1.000
51	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(2), NFYB(1), NFYC(2), SP1(2), SP3(3)	2766602	10	10	10	2	0	1	2	4	3	0	0.580	0.439	1.000
52	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), CHRNB1(2), CHRNG(1), MUSK(6), PIK3R1(4), PTK2(9), PTK2B(5), SRC(3), TERT(2)	8346267	34	27	34	4	0	13	3	9	9	0	0.0482	0.445	1.000
53	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(2), IL6(2), LDLR(2), LPL(1)	2959650	9	9	9	1	1	1	1	5	1	0	0.293	0.460	1.000
54	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(6), ACO2(3), FH(3), IDH2(4), MDH1(1), SDHB(1), SUCLA2(2)	4554533	20	19	20	4	1	4	3	7	5	0	0.407	0.470	1.000
55	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(10), GNB1(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1)	5670295	23	21	20	3	6	6	2	4	5	0	0.157	0.479	1.000
56	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7)	3673000	30	26	27	8	0	5	1	15	9	0	0.718	0.485	1.000
57	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(8), MEF2A(6), MEF2C(1), MEF2D(3), MYOD1(1)	4925385	22	21	22	4	0	4	2	13	3	0	0.268	0.490	1.000
58	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(2), FOS(1), IGF1R(11), IRS1(3), JUN(2), MAPK8(1), PIK3R1(4), PTPN11(4), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1)	12736457	52	41	52	6	3	10	9	13	16	1	0.0127	0.492	1.000
59	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	11	CREB1(1), FOS(1), JUN(2), MAPK1(3), MAPK14(3), MAPK8(1), PRKCA(1)	3852689	12	12	12	0	1	2	3	2	4	0	0.0303	0.508	1.000
60	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(2), AKT2(3), AKT3(2), CAB39(2), DDIT4(1), EIF4B(1), FIGF(1), HIF1A(3), INS(1), MAPK1(3), PDPK1(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PRKAA1(4), RHEB(1), RICTOR(8), RPS6(2), RPS6KA1(1), RPS6KA2(5), RPS6KA6(8), RPS6KB1(2), RPS6KB2(4), STK11(1), TSC1(8), TSC2(12), ULK1(3), ULK2(5), ULK3(1), VEGFA(1), VEGFC(6)	28758861	116	81	112	9	7	29	12	29	39	0	5.18e-06	0.508	1.000
61	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(1), AGTR1(2), BDKRB2(3), KNG1(3), NOS3(9)	5740674	22	20	21	3	2	6	2	7	5	0	0.129	0.541	1.000
62	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(10), HADHA(3), SDS(2)	2746271	17	9	17	4	0	3	4	6	4	0	0.454	0.554	1.000
63	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(3)	1120947	3	3	3	0	0	2	0	1	0	0	0.415	0.560	1.000
64	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(1), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2D3(4), UBE2E1(1), UBE2J1(3), UBE2J2(2), UBE2L3(1), UBE2N(4), UBE3A(1)	5920459	21	18	21	2	0	4	4	6	7	0	0.112	0.570	1.000
65	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(4), GLUD1(3), OAT(2), PRODH(1)	3381489	12	10	12	0	0	5	2	2	3	0	0.0467	0.572	1.000
66	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(9), BCL2(1), CASP3(3), CASP9(1), DAXX(1), FAS(3), HSPB1(1), HSPB2(1), MAPKAPK2(1), MAPKAPK3(1), TNF(1)	6278515	24	22	24	4	0	13	2	4	5	0	0.139	0.575	1.000
67	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3G(1), CD80(4), CD86(2), CTLA4(1), HLA-DRA(1), HLA-DRB1(1), ITK(1), LCK(4), PIK3R1(4), PTPN11(4)	5914485	23	19	23	3	0	6	1	10	6	0	0.179	0.580	1.000
68	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(3), FOS(1), FYN(1), JUN(2), MAPK14(3), THBS1(6)	3989581	19	18	19	4	3	1	4	7	4	0	0.376	0.583	1.000
69	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(7), DYRK1B(2), GLI2(12), GLI3(11), GSK3B(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), SHH(1), SMO(1), SUFU(3)	9592315	48	43	47	8	7	8	1	18	14	0	0.0793	0.597	1.000
70	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	1007741	2	2	2	0	0	1	0	0	1	0	0.717	0.598	1.000
71	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(2), FOS(1), INS(1), INSR(4), IRS1(3), JUN(2), MAPK8(1), PIK3R1(4), PTPN11(4), RAF1(2), RASA1(10), SHC1(3), SLC2A4(2), SOS1(8), SRF(1)	13158957	48	41	48	6	3	9	9	11	15	1	0.0173	0.600	1.000
72	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP2E1(4), NR1I3(2), PTGS1(2), PTGS2(3)	2927653	11	11	11	3	2	2	0	4	3	0	0.694	0.611	1.000
73	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(3), NFKBIA(2), PLCB1(8), PRKCA(1), RELA(4)	4678537	19	18	19	4	0	5	2	7	5	0	0.455	0.616	1.000
74	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFV2(2)	3999223	14	14	14	2	0	3	2	9	0	0	0.219	0.620	1.000
75	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3G(1), GZMB(2), HLA-A(3), ICAM1(1), ITGAL(5), ITGB2(8), PRF1(4)	4813374	25	22	24	4	2	8	0	9	6	0	0.281	0.622	1.000
76	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	AKT1(2), IL2RG(1), IL4(1), IL4R(1), IRS1(3), JAK3(7), RPS6KB1(2), SHC1(3), STAT6(5)	7002331	25	21	24	2	5	4	3	7	6	0	0.0386	0.623	1.000
77	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(1)	1312979	3	3	3	1	0	0	0	3	0	0	0.860	0.626	1.000
78	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(2), SPCS3(2)	1757643	7	5	7	2	0	2	2	2	1	0	0.640	0.632	1.000
79	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL16(7), IL18(2), IL4(1), IL5(1), IL6(2), TNF(1)	5551349	28	26	27	6	0	5	6	14	3	0	0.237	0.642	1.000
80	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(4), ACTN2(6), BCAR1(3), BCR(2), CAPN1(2), CAPNS1(1), CAV1(1), CSK(1), FYN(1), ITGA1(5), JUN(2), MAP2K2(2), MAPK1(3), MAPK8(1), PPP1R12B(4), PTK2(9), PXN(2), RAF1(2), RAP1A(2), ROCK1(6), SHC1(3), SOS1(8), SRC(3), TLN1(10), VCL(3), ZYX(2)	26968140	89	65	89	3	6	26	13	24	19	1	8.17e-08	0.654	1.000
81	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(9), ATM(9), BAX(3), BCL2(1), CASP3(3), CASP6(2), CASP9(1), PRKCA(1), PTK2(9), PXN(2), STAT1(5), TLN1(10)	14808116	57	48	56	6	5	18	3	19	12	0	0.00454	0.673	1.000
82	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(1)	934726	2	2	2	0	0	0	0	1	1	0	0.564	0.680	1.000
83	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY1(1), CRY2(1), CSNK1E(3), PER1(6)	4818668	12	11	12	2	0	5	1	5	0	1	0.355	0.682	1.000
84	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), GNAQ(1), JUN(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK14(3), MAPK8(1), PAK1(3), PLCG1(7), PRKCA(1), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), SRC(3), SYT1(2)	16100120	58	52	57	6	3	12	7	20	15	1	0.0135	0.682	1.000
85	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(2), EPX(3), HPD(2), LPO(4), MAOA(1), MAOB(8), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TAT(3), TPO(13)	12507820	52	44	52	5	3	11	7	16	15	0	0.00551	0.682	1.000
86	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDPS(2), HMGCR(6), IDI1(1), LSS(5), MVD(3), MVK(2), NQO1(2), PMVK(3), SQLE(1)	6311359	26	21	26	4	2	6	5	8	4	1	0.134	0.705	1.000
87	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDPS(2), HMGCR(6), HMGCS1(2), IDI1(1), LSS(5), MVD(3), MVK(2), NSDHL(1), PMVK(3), SQLE(1)	7496642	27	22	27	4	2	7	5	7	5	1	0.121	0.714	1.000
88	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(3), CCNE1(1), CDC34(1), CUL1(2), E2F1(3), SKP2(1), TFDP1(2)	3893220	13	11	13	2	0	2	3	5	3	0	0.386	0.726	1.000
89	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(4), FUT9(4), GCNT2(1)	3499754	10	9	10	1	1	0	1	7	1	0	0.232	0.728	1.000
90	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS1(1), DHRS3(1), DHRS7(1), HEMK1(3), LCMT2(3), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), WBSCR22(2)	8364562	30	29	30	5	5	7	4	10	3	1	0.134	0.734	1.000
91	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	ARF1(1), CCND1(1), CDKN1B(5), CFL1(1), E2F1(3), MDM2(1)	3790629	12	12	11	2	0	1	0	7	4	0	0.459	0.737	1.000
92	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), TAT(3), TYR(5)	2615122	10	10	10	3	0	2	2	3	3	0	0.619	0.741	1.000
93	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(4), ACTN2(6), BCAR1(3), CSK(1), CTNNA1(3), CTNNA2(10), PTK2(9), PXN(2), SRC(3), VCL(3)	10111890	44	36	44	5	2	10	4	19	9	0	0.0350	0.741	1.000
94	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1)	7596124	21	18	21	1	1	5	2	7	6	0	0.0324	0.748	1.000
95	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	6	CDC25B(2), CHEK1(5), NEK1(1), WEE1(2)	4158412	10	10	10	0	1	1	2	1	5	0	0.106	0.749	1.000
96	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), FMOD(1), KERA(1), LUM(5)	1999539	9	9	9	3	0	3	0	4	2	0	0.776	0.753	1.000
97	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GGT1(1), SHMT1(2), SHMT2(4)	3246244	8	8	8	1	1	4	1	1	1	0	0.220	0.755	1.000
98	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(10), GNB1(2), PRKACA(2)	3834275	19	18	16	4	6	4	1	6	2	0	0.451	0.758	1.000
99	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(1), GH1(1), GHR(3), IGF1R(11), PIK3R1(4), SHC1(3)	6195872	25	20	25	4	3	4	3	6	9	0	0.135	0.773	1.000
100	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(5), APC(12), BTRC(5), DLL1(2), DVL1(3), FZD1(2), GSK3B(3), NOTCH1(7), PSEN1(2), WNT1(2)	10720675	43	41	43	8	5	11	5	15	6	1	0.0785	0.777	1.000
101	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMD14(1), RPN1(1), RPN2(2), UBE3A(1)	7449521	25	22	25	3	0	10	3	8	4	0	0.0742	0.787	1.000
102	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25B(2), CDC25C(3), CSK(1), PRKCA(1), PTPRA(4), SRC(3)	5258311	16	16	16	3	0	2	2	7	5	0	0.385	0.791	1.000
103	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(5), ACYP1(1), ECHS1(2), EHHADH(10), GCDH(1), HADHA(3), SDHB(1), SDS(2)	4383370	27	18	27	7	0	5	6	9	7	0	0.472	0.799	1.000
104	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1), SLPI(1)	922839	2	2	2	2	0	0	1	0	1	0	0.962	0.801	1.000
105	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), CPOX(1), FECH(1), HMBS(4), PPOX(3)	4427944	12	12	12	2	1	1	1	2	7	0	0.384	0.805	1.000
106	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(1), F2RL3(1), GNAI1(4), GNB1(2), ITGA1(5), MAPK1(3), PLA2G4A(8), PLCB1(8), PRKCA(1), PTGS1(2), PTK2(9), RAF1(2), SRC(3), SYK(1)	13732862	52	46	52	7	1	18	5	17	11	0	0.0165	0.809	1.000
107	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	19	CSNK2A1(2), FOS(1), IL6(2), IL6R(3), JAK2(4), JAK3(7), JUN(2), PTPN11(4), RAF1(2), SHC1(3), SOS1(8), SRF(1), STAT3(4)	11346266	43	33	42	5	5	9	9	13	6	1	0.0136	0.809	1.000
108	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(3)	1466952	3	3	3	2	0	1	0	0	2	0	0.946	0.813	1.000
109	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), BCL2(1), CBL(4), CFLAR(2), E2F1(3), FOS(1), IL2RA(1), IL2RB(2), IL2RG(1), IRS1(3), JAK3(7), MAPK1(3), MYC(2), NMI(2), PIK3R1(4), PTPN6(2), RAF1(2), RPS6KB1(2), SHC1(3), SOCS3(1), SOS1(8), STAT5A(2), STAT5B(1), SYK(1)	17962566	60	53	59	7	8	10	11	18	12	1	0.00377	0.815	1.000
110	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2)	3124428	12	12	12	3	0	1	2	4	5	0	0.687	0.821	1.000
111	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(2), EIF4A2(3), EIF4B(1), EIF4G1(7), EIF4G2(4), EIF4G3(6), MKNK1(2), PDK2(1), PDPK1(1), PIK3R1(4), PPP2CA(2), RPS6(2), RPS6KB1(2), TSC1(8), TSC2(12)	14192041	57	44	54	8	1	13	7	10	25	1	0.0311	0.823	1.000
112	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(5), AKT1(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREB1(1), GNAS(10), MAPK1(3), MAPK14(3), PIK3R1(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), RPS6KA1(1), RPS6KA5(5), SOS1(8)	15534627	62	49	58	7	10	15	7	13	16	1	0.00582	0.830	1.000
113	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(11), RANGAP1(2)	4604493	14	13	13	3	1	3	3	5	2	0	0.326	0.830	1.000
114	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3G(1)	647938	1	1	1	0	0	1	0	0	0	0	0.700	0.836	1.000
115	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(9), CR2(9), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8)	9529633	46	41	45	9	1	13	8	17	7	0	0.115	0.841	1.000
116	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3G(1), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1)	5907583	25	22	24	4	1	11	4	6	3	0	0.128	0.855	1.000
117	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(2)	1201148	2	2	2	1	0	0	0	0	2	0	1.000	0.859	1.000
118	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), JUN(2), MAPK1(3), MYC(2), NFKB1(3), NFKBIA(2), PLCB1(8), PRKCA(1), RAF1(2), RELA(4), TNF(1)	8646820	31	30	31	5	1	8	4	12	6	0	0.149	0.862	1.000
119	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(1), CSF1(2), IL4(1), IL5(1), IL6(2), IL7(1)	3557060	9	9	9	2	0	2	1	5	1	0	0.552	0.865	1.000
120	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(2), FOS(1), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), PDGFA(2), PDGFRA(5), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1), STAT1(5), STAT3(4), STAT5A(2)	17247433	67	52	65	9	2	14	8	19	23	1	0.0368	0.870	1.000
121	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), GGPS1(1), IDI1(1), IDI2(1), SQLE(1)	2467083	6	6	6	0	0	1	2	1	2	0	0.230	0.875	1.000
122	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2), IDI1(1), SQLE(1)	1871733	4	4	4	0	0	1	1	1	1	0	0.366	0.875	1.000
123	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(8), ABCB11(2), ABCB4(5), ABCC1(3), ABCC3(5), GSTP1(2)	8136463	25	24	25	4	1	5	4	10	5	0	0.151	0.877	1.000
124	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(3), AKT1(2), ANXA1(1), GNAS(10), GNB1(2), NFKB1(3), NOS3(9), NR3C1(3), PIK3R1(4), RELA(4), SYT1(2)	9164224	43	37	39	8	7	9	3	13	11	0	0.255	0.877	1.000
125	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(1), DDX20(3), E2F1(3), E2F4(2), ETS1(2), ETS2(1), ETV3(4), FOS(1), HDAC2(3), HDAC5(4), JUN(2), NCOR2(14), RBL1(4), RBL2(11), SIN3A(3), SIN3B(3)	15429560	63	53	61	9	8	9	10	21	15	0	0.0229	0.887	1.000
126	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3G(1), CD4(1), CD58(1), CD8A(1), IL6(2), KITLG(2)	3551152	8	8	8	2	0	3	1	2	2	0	0.599	0.889	1.000
127	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(2), F2R(1), F3(1), F5(7), FGA(12), FGB(3), PROC(2), SERPINC1(2), TFPI(2)	9301489	35	33	34	5	1	9	6	11	8	0	0.0662	0.898	1.000
128	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(3), CXCL12(1), CXCR4(2), GNAI1(4), GNAQ(1), GNB1(2), MAPK1(3), NFKB1(3), PIK3C2G(7), PIK3R1(4), PLCG1(7), PRKCA(1), PTK2(9), PTK2B(5), PXN(2), RAF1(2), RELA(4)	14728396	60	49	59	8	0	19	4	21	16	0	0.0362	0.900	1.000
129	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), SDHA(2), SDHB(1)	3652134	7	6	7	0	0	1	1	1	4	0	0.136	0.904	1.000
130	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	13	APAF1(9), ATM(9), BAX(3), BCL2(1), CCND1(1), CCNE1(1), E2F1(3), MDM2(1), TIMP3(1)	8510655	29	28	28	5	3	8	0	15	3	0	0.168	0.909	1.000
131	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(9), CDC25B(2), CDC25C(3), CHEK1(5), MYT1(2), WEE1(2)	7807729	23	22	23	4	2	2	2	10	7	0	0.340	0.921	1.000
132	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(2), AOC3(1), CES1(3)	3419440	6	6	6	1	1	1	1	2	1	0	0.353	0.923	1.000
133	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(2), MRPS7(1), RPL10A(2), RPL11(3), RPL13(2), RPL18(1), RPL18A(3), RPL19(1), RPL21(1), RPL23A(1), RPL27(1), RPL28(1), RPL3(3), RPL35A(1), RPL36A(1), RPL37(1), RPL8(1), RPL9(1), RPS10(1), RPS13(1), RPS2(1), RPS23(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS6(2), RPS7(1), RPS9(1)	12138737	41	34	40	5	5	14	4	10	8	0	0.0367	0.932	1.000
134	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2)	8520430	30	29	29	5	0	8	2	12	8	0	0.263	0.933	1.000
135	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2)	8520430	30	29	29	5	0	8	2	12	8	0	0.263	0.933	1.000
136	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2)	8520430	30	29	29	5	0	8	2	12	8	0	0.263	0.933	1.000
137	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACAT1(2), ECHS1(2), HADHA(3)	3092657	10	8	10	4	0	3	0	3	4	0	0.872	0.933	1.000
138	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASS(5)	2623568	7	7	7	2	0	2	2	1	2	0	0.695	0.934	1.000
139	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(1), FUCA2(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), MAN2C1(5), MANBA(1), NEU1(2), NEU2(4), NEU3(2), NEU4(2)	9607867	33	30	32	5	2	9	6	10	6	0	0.0512	0.934	1.000
140	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK2(4), JAK3(7), MAPK1(3), STAT3(4), TYK2(1)	5518222	19	17	18	4	4	3	3	7	2	0	0.292	0.934	1.000
141	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(2), CREB1(1), MAPK1(3), MAPK7(3), MEF2A(6), MEF2C(1), MEF2D(3), NTRK1(5), PIK3R1(4), PLCG1(7), RPS6KA1(1), SHC1(3)	10040742	39	33	38	6	3	8	3	13	12	0	0.154	0.935	1.000
142	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST6GALNAC2(3)	3150051	6	6	6	1	0	2	1	1	2	0	0.627	0.936	1.000
143	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3G(1), CD4(1), FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(4), PTPRC(8), ZAP70(3)	5117434	20	17	20	4	0	3	3	11	3	0	0.437	0.936	1.000
144	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(2), E2F1(3), MDM2(1), MYC(2), PIK3R1(4), POLR1A(7), POLR1B(2), POLR1C(1), TBX2(2), TWIST1(2)	8451429	26	24	26	4	3	3	0	9	11	0	0.312	0.937	1.000
145	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(1), CDC25B(2), CDC25C(3), SHH(1), XPO1(5)	4987515	14	13	14	3	0	1	2	7	4	0	0.504	0.940	1.000
146	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(2), PAPSS1(2), PAPSS2(1), SULT1A2(1), SULT1E1(1), SUOX(2)	4723320	9	9	9	1	0	3	3	2	1	0	0.213	0.940	1.000
147	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), FDXR(1), SHMT1(2)	9059599	31	29	30	5	0	9	2	12	8	0	0.225	0.942	1.000
148	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), HEMK1(3), LCMT2(3), METTL2B(5), METTL6(3), PCYT1A(3), PCYT1B(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), WBSCR22(2)	7864935	32	30	32	7	4	8	5	9	5	1	0.308	0.943	1.000
149	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(6), MPI(2), PGM1(1), PYGL(2), PYGM(8), TPI1(1)	7781155	23	22	23	4	2	6	5	7	3	0	0.117	0.944	1.000
150	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(1), CDC34(1), CUL1(2), E2F1(3), FBXW7(3), TFDP1(2)	3770122	12	10	12	3	0	2	3	5	2	0	0.562	0.945	1.000
151	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(3), CPO(1), FECH(1), GATA1(3), HMBS(4)	4793392	12	12	12	2	1	2	0	2	7	0	0.390	0.946	1.000
152	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(1), DOCK1(7), FOS(1), GAB1(3), HGF(7), ITGA1(5), JUN(2), MAP2K2(2), MAP4K1(1), MAPK1(3), MAPK8(1), MET(2), PAK1(3), PIK3R1(4), PTK2(9), PTK2B(5), PTPN11(4), PXN(2), RAF1(2), RAP1A(2), RASA1(10), SOS1(8), SRC(3), STAT3(4)	24032745	91	67	90	10	3	28	10	30	19	1	0.000431	0.947	1.000
153	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(2), BCL2(1), BCR(2), FOS(1), JAK2(4), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), MYC(2), PIK3R1(4), RAF1(2), SOS1(8), STAT1(5), STAT5A(2), STAT5B(1)	14428763	44	38	44	5	2	8	6	12	15	1	0.0399	0.948	1.000
154	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(5), HMGCL(2), OXCT1(2)	1906981	11	10	10	5	0	2	1	5	3	0	0.874	0.950	1.000
155	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), ZNRD1(1)	12986450	35	28	35	1	2	8	2	10	13	0	0.00343	0.951	1.000
156	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(3), MMP2(1), MMP9(3), RECK(3), TIMP1(2), TIMP3(1), TIMP4(3)	4337630	16	15	16	4	1	4	1	7	3	0	0.499	0.953	1.000
157	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	BPNT1(2), CHST11(2), CHST12(2), CHST13(3), PAPSS1(2), PAPSS2(1), SULT1A2(1), SULT1E1(1), SUOX(2)	6543804	16	15	16	2	1	3	3	6	3	0	0.191	0.960	1.000
158	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(2), CCND1(1), CCNE1(1), CDK6(1), CDKN1B(5), E2F1(3), MAPK1(3), NFKB1(3), NFKBIA(2), PAK1(3), PIK3R1(4), RAF1(2), RELA(4), TFDP1(2)	9054146	36	29	35	6	0	6	3	15	12	0	0.210	0.961	1.000
159	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(13), EPHB1(5), FYN(1), ITGA1(5), L1CAM(7), LYN(1), SELP(1)	8792317	34	32	34	7	5	11	2	10	6	0	0.198	0.961	1.000
160	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(4), IL6(2), KITLG(2), TGFB1(1), TGFB2(4), TGFB3(2)	4872769	16	16	16	4	1	5	3	4	3	0	0.441	0.961	1.000
161	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(9), BAX(3), BCL10(1), BCL2(1), CASP9(1), CES1(3)	6585107	18	16	17	4	2	10	1	2	3	0	0.196	0.962	1.000
162	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(4), ACTN2(6), CAPN1(2), CAPNS1(1), ITGA1(5), ITGB3(5), PTK2(9), PXN(2), SPTAN1(7), SRC(3), TLN1(10)	16342824	55	45	55	7	5	21	3	13	13	0	0.0224	0.962	1.000
163	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(2), FOS(1), JAK2(4), JUN(2), MPL(1), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), STAT1(5), STAT3(4), STAT5A(2), STAT5B(1)	15686535	57	45	55	9	2	13	6	17	18	1	0.117	0.962	1.000
164	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(3), PIGA(1), PIGB(1), PIGC(2), PIGL(2), PIGM(4), PIGN(6), PIGO(2), PIGQ(3), PIGS(5), PIGV(2), PIGW(3), PIGZ(4)	13978282	42	37	42	5	4	7	3	16	12	0	0.0596	0.963	1.000
165	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(1), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(8), PLCB2(3), PRL(3), TRH(2)	6309982	28	26	27	6	3	11	1	7	6	0	0.205	0.965	1.000
166	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), CTH(2), GGT1(1), MARS(6), MAT1A(4), PAPSS1(2), PAPSS2(1), SCLY(1)	7034688	20	18	20	3	2	6	1	7	4	0	0.239	0.965	1.000
167	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(6), EGFR(6), HGS(4), TF(3), TFRC(2)	7175766	26	26	25	8	0	8	1	5	12	0	0.882	0.966	1.000
168	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(3), DIAPH1(5), FYN(1), GSN(2), ITGA1(5), MAPK1(3), MYLK(3), PIK3R1(4), PTK2(9), PXN(2), RAF1(2), ROCK1(6), SHC1(3), SRC(3), TLN1(10)	20029317	61	47	61	5	3	14	5	21	18	0	0.00123	0.968	1.000
169	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(1), ENPP6(2), PAFAH1B1(1), PAFAH1B2(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(3), PPAP2B(1), PPAP2C(2)	13365847	54	40	52	9	3	8	9	17	17	0	0.0379	0.970	1.000
170	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(3), ARFGAP3(1), ARFGEF2(5), CLTB(1), COPA(4), GBF1(4), GPLD1(2), KDELR1(1), KDELR2(2), KDELR3(1)	9097975	25	23	25	4	1	7	3	7	7	0	0.157	0.971	1.000
171	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(1), RDH11(1), RDH13(1), RDH14(1)	2643009	5	5	5	2	1	2	0	1	1	0	0.831	0.971	1.000
172	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(2)	2272848	3	3	3	1	0	2	0	0	1	0	0.779	0.972	1.000
173	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(8), AKT1(2), ATM(9), BAX(3), CPB2(2), CSNK1A1(2), HIF1A(3), IGFBP3(2), MAPK8(1), MDM2(1), NQO1(2)	11566484	35	33	33	5	3	6	2	19	5	0	0.131	0.973	1.000
174	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(5), ARHGEF1(1), F2(2), F2R(1), F2RL3(1), GNA12(1), GNA13(1), GNAI1(4), GNAQ(1), GNB1(2), MAP3K7(3), PIK3R1(4), PLCB1(8), PPP1R12B(4), PRKCA(1), PTK2B(5), ROCK1(6)	13338231	50	41	50	8	0	14	4	15	17	0	0.0976	0.973	1.000
175	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATIC(2), ATP6V0C(2), GART(4), MTHFD1(4), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTR(3), SHMT1(2), SHMT2(4), TYMS(1)	10037867	28	23	27	2	0	8	1	12	7	0	0.0186	0.975	1.000
176	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CAMKK1(1), CAMKK2(3), CREB1(1), SYT1(2)	6714282	21	19	21	4	1	5	2	7	6	0	0.291	0.975	1.000
177	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1)	2113739	2	2	2	1	0	0	0	2	0	0	0.888	0.976	1.000
178	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT5(2), B3GNT5(1), FUT1(4), FUT3(2)	4027599	10	9	10	3	1	3	1	4	1	0	0.580	0.977	1.000
179	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(2), PRKCA(1), TGM2(1)	2870851	5	5	5	2	1	1	0	1	2	0	0.701	0.977	1.000
180	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), CDC42(3), WASF1(1), WASL(2)	4628812	15	15	15	4	2	7	4	1	1	0	0.297	0.978	1.000
181	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(10), CPT1A(4), LEP(2), LEPR(4), PRKAA1(4), PRKAB2(1), PRKAG2(3)	8040720	28	26	28	5	3	5	1	10	9	0	0.290	0.979	1.000
182	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), FPGS(1)	4019923	9	9	9	3	0	1	2	4	2	0	0.764	0.981	1.000
183	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(1), COPS5(1), CREB1(1), EDN1(2), EP300(11), HIF1A(3), JUN(2), LDHA(1), NOS3(9), P4HB(1)	9622891	34	29	31	5	1	10	2	14	7	0	0.141	0.981	1.000
184	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(3), CTH(2), GGT1(1), HEMK1(3), LCMT2(3), MARS(6), MAT1A(4), METTL2B(5), METTL6(3), PAPSS1(2), PAPSS2(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SCLY(1), WBSCR22(2)	14081397	47	40	47	8	6	13	5	15	7	1	0.0915	0.982	1.000
185	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(1), EGFR(6), GNAQ(1), JUN(2), MAP2K2(2), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK8(1), MEF2A(6), MEF2C(1), MEF2D(3), PAK1(3), PRKCA(1), PTK2(9), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), SRC(3), SYT1(2)	19383769	72	61	71	11	2	19	8	27	15	1	0.0441	0.982	1.000
186	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR24(1), DHCR7(1), FDPS(2), GGCX(4), GGPS1(1), HMGCR(6), HSD17B7(1), IDI1(1), IDI2(1), LSS(5), MVD(3), MVK(2), NQO1(2), NSDHL(1), PMVK(3), SQLE(1), TM7SF2(2)	11056012	37	30	37	5	3	9	6	9	9	1	0.0580	0.983	1.000
187	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(5), HDC(4), TH(1), TPH1(2)	3406519	12	11	12	4	3	2	1	2	4	0	0.626	0.984	1.000
188	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), JUN(2), OPRK1(3), POLR2A(7), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3)	7202874	22	19	21	3	0	7	1	10	4	0	0.288	0.985	1.000
189	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), ATIC(2), FTCD(3), GART(4), MTFMT(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTR(3), SHMT1(2), SHMT2(4), TYMS(1)	10833244	30	24	29	2	0	8	1	11	10	0	0.0252	0.986	1.000
190	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(5), LARS(1), LARS2(2), PDHA1(1), PDHA2(3), PDHB(2)	5582199	16	15	16	4	1	6	1	6	2	0	0.379	0.986	1.000
191	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(2), FOS(1), IL2RA(1), IL2RB(2), IL2RG(1), JAK3(7), JUN(2), LCK(4), MAPK8(1), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1), SYK(1)	12248788	38	31	38	5	5	7	9	11	5	1	0.0208	0.987	1.000
192	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GHR(3), INS(1), INSR(4), IRS1(3), JAK2(4), MAPK1(3), PIK3R1(4), PLCG1(7), PRKCA(1), PTPN6(2), RAF1(2), RPS6KA1(1), SHC1(3), SLC2A4(2), SOS1(8), SRF(1), STAT5A(2), STAT5B(1)	17575838	53	47	52	8	6	8	10	13	15	1	0.0298	0.988	1.000
193	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(6), GNAS(10), GNB1(2), IGF1R(11), MAP2K2(2), MAPK1(3), MKNK1(2), MKNK2(3), MYC(2), NGFR(3), PDGFRA(5), PPP2CA(2), PTPRR(2), RAF1(2), RPS6KA1(1), RPS6KA5(5), SHC1(3), SOS1(8), SRC(3), STAT3(4)	19157889	79	65	73	11	13	16	10	29	10	1	0.0102	0.989	1.000
194	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADVL(2), ACSL1(1), ACSL3(2), CPT1A(4), CPT2(1), EHHADH(10), HADHA(3), PECR(3), SCP2(3)	9447068	32	23	32	7	1	5	5	9	12	0	0.381	0.990	1.000
195	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	24	AKT1(2), AKT2(3), AKT3(2), CISH(5), IARS(5), IL13RA1(2), IL2RG(1), IL4(1), IL4R(1), JAK2(4), JAK3(7), NR0B2(4), PPP1R13B(4), RPS6KB1(2), SERPINA4(2), SHC1(3), SOS1(8), SOS2(4), SRC(3), STAT6(5), TYK2(1)	18261574	69	56	68	10	9	19	9	17	14	1	0.0104	0.991	1.000
196	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(4)	3438324	10	10	10	5	2	1	1	3	3	0	0.922	0.992	1.000
197	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1)	4505528	8	8	8	2	0	2	0	5	1	0	0.569	0.992	1.000
198	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1)	4505528	8	8	8	2	0	2	0	5	1	0	0.569	0.992	1.000
199	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(2), CXCL12(1), CXCR4(2), FOS(1), GNAQ(1), JUN(2), MAPK14(3), MAPK8(1), PLCG1(7), PRKCA(1), PTK2B(5), SYT1(2)	7593077	28	27	27	6	1	9	2	9	7	0	0.350	0.992	1.000
200	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	29	AKT1(2), AKT2(3), AKT3(2), BCR(2), CD19(2), DAPP1(1), FLOT1(3), GAB1(3), ITPR1(15), ITPR2(11), ITPR3(11), LYN(1), NR0B2(4), PDK1(1), PHF11(3), PITX2(1), PLCG2(7), PPP1R13B(4), PREX1(16), PTPRC(8), RPS6KA1(1), RPS6KA2(5), RPS6KB1(2), SAG(2), SYK(1), VAV1(3)	28642020	114	85	112	14	14	24	13	47	16	0	0.000519	0.992	1.000
201	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	CISH(5), IL6(2), IL6R(3), JAK2(4), JAK3(7), PIAS3(1), PTPRU(2), REG1A(1), SRC(3), STAT3(4)	7458604	32	26	31	7	3	8	4	12	5	0	0.291	0.992	1.000
202	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(12), BTRC(5), CCND1(1), CREBBP(6), CSNK1A1(2), CSNK2A1(2), CTBP1(1), DVL1(3), FZD1(2), GSK3B(3), MAP3K7(3), MYC(2), NLK(2), PPP2CA(2), TLE1(6), WIF1(6), WNT1(2)	15325905	60	51	59	10	2	16	3	22	16	1	0.0761	0.993	1.000
203	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO3(1), FARS2(1), PAH(2), TAT(3)	4574562	9	9	9	6	0	1	3	0	5	0	0.934	0.993	1.000
204	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(1), BMPR1B(2), BMPR2(5)	3457871	8	7	8	3	1	2	1	0	4	0	0.782	0.993	1.000
205	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(2), F2(2), F2R(1), FGA(12), FGB(3), PLAT(2), PLG(3), SERPINB2(3), SERPINE1(1)	7484200	31	30	31	8	1	9	7	6	8	0	0.386	0.993	1.000
206	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), CASP9(1), CHUK(8), GH1(1), GHR(3), NFKB1(3), NFKBIA(2), PDPK1(1), PIK3R1(4), PPP2CA(2), RELA(4)	7060355	31	25	31	7	1	7	4	8	11	0	0.445	0.993	1.000
207	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3G(1), CD4(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1)	6222513	25	22	24	5	1	10	4	7	3	0	0.252	0.993	1.000
208	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	12	BLVRA(1), HMOX1(1), IL10(1), IL10RA(3), IL10RB(2), IL6(2), STAT1(5), STAT3(4), STAT5A(2), TNF(1)	5583014	22	21	21	6	0	7	2	12	1	0	0.544	0.993	1.000
209	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(2), ADCY9(6), AK1(1), ARF1(1), ARF5(1), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), ERO1L(1), GNAS(10), PDIA4(2), PLCG1(7), PLCG2(7), PRKCA(1), SEC61A1(2), TRIM23(1)	21063462	69	57	64	9	8	17	4	24	16	0	0.0329	0.994	1.000
210	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), DPYD(6), DPYS(1), ENPP1(1), ENPP3(4), PANK1(1), PANK2(2), PANK4(4), PPCS(1), UPB1(1)	7997683	23	18	23	4	2	7	4	8	2	0	0.146	0.994	1.000
211	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	5	IFNG(3), IFNGR1(3), IFNGR2(1), JAK2(4), STAT1(5)	3269155	16	14	16	6	0	4	1	7	4	0	0.857	0.994	1.000
212	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	MAP2K2(2), MAPK1(3), NGFR(3), RAF1(2)	4765427	10	10	10	3	0	2	1	5	2	0	0.679	0.995	1.000
213	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(1), BCR(2), BLNK(3), FOS(1), JUN(2), LYN(1), MAP3K1(3), MAPK1(3), MAPK8IP3(2), PAPPA(5), RPS6KA1(1), SHC1(3), SOS1(8), SYK(1), VAV1(3), VAV3(8)	17388623	47	43	47	6	4	14	8	17	3	1	0.0159	0.995	1.000
214	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), EPOR(1), FOS(1), JAK2(4), JUN(2), MAPK8(1), PLCG1(7), PTPN6(2), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1)	12429490	36	30	35	5	3	7	5	11	9	1	0.117	0.996	1.000
215	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(6), ACO2(3), CS(4), HAO1(1), MDH1(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2)	7139632	23	22	23	5	1	5	0	9	8	0	0.418	0.996	1.000
216	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(5), BDH1(2), BDH2(1), HMGCL(2), HMGCS1(2), HMGCS2(2), OXCT1(2)	4280853	18	16	17	6	0	4	1	7	6	0	0.783	0.996	1.000
217	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(1), HLA-A(3), IL18(2), KLRC1(1), KLRC3(2), KLRC4(1), LAT(1), PAK1(3), PIK3R1(4), PTK2B(5), PTPN6(2), SYK(1), VAV1(3)	9449032	29	27	29	6	1	5	2	10	11	0	0.403	0.996	1.000
218	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), F2(2), FYN(1), GNAI1(4), GNB1(2), JAK2(4), MAP2K2(2), MAPK1(3), MAPK14(3), MAPK8(1), MAPT(6), MYLK(3), PLCG1(7), PRKCA(1), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), STAT1(5), STAT3(4), STAT5A(2), SYT1(2)	23927797	82	66	80	11	5	23	9	24	20	1	0.00818	0.996	1.000
219	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(6), EGFR(6), ERBB3(8), NRG1(2), UBE2D1(1)	5717894	23	22	22	9	0	5	3	9	6	0	0.882	0.996	1.000
220	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), SP1(2), SP3(3), SYT1(2)	11503655	40	35	38	9	5	8	5	14	8	0	0.277	0.996	1.000
221	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(3), AKT3(2), BCL2(1), GSK3A(1), GSK3B(3), IL4R(1), IRS1(3), IRS2(2), JAK3(7), MAP4K1(1), MAPK1(3), PDK1(1), PIK3CD(5), PIK3R1(4), PPP1R13B(4), RAF1(2), SHC1(3), SOS1(8), SOS2(4), STAT6(5)	18292182	65	54	65	10	11	16	11	10	16	1	0.00928	0.996	1.000
222	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(6), CAMK2B(2), CAMK2G(3), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), NFAT5(6), PDE6A(7), PDE6B(8), SLC6A13(4), TF(3)	20584781	82	65	81	12	9	23	3	29	18	0	0.0223	0.996	1.000
223	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FHL5(2), FSHR(4), GNAS(10), XPO1(5)	5487411	26	25	23	6	6	3	2	11	4	0	0.510	0.996	1.000
224	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(2), ST3GAL1(1), ST3GAL2(1)	4359855	9	9	9	3	1	0	0	5	3	0	0.875	0.996	1.000
225	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(1), TPI1(1)	2185055	3	3	3	3	0	0	0	2	1	0	0.945	0.997	1.000
226	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(9), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP8(1), CASP9(1), DFFB(1), GZMB(2), PRF1(4), SCAP(5), SREBF1(3), SREBF2(3)	10646841	39	33	39	9	3	10	1	9	15	1	0.518	0.997	1.000
227	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(1), GNA12(1), GNA13(1), GNAQ(1), GNB1(2), MYLK(3), PLCB1(8), PPP1R12B(4), PRKCA(1), ROCK1(6)	11611646	31	27	31	5	0	6	4	10	11	0	0.229	0.997	1.000
228	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY1(1), CRY2(1), CSNK1E(3), NPAS2(4), NR1D1(1), PER1(6), PER2(4), PER3(5)	9679464	26	23	26	5	1	8	3	9	4	1	0.297	0.997	1.000
229	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(6), ACO2(3), CS(4), HAO1(1), MDH1(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2)	7491796	23	22	23	5	1	5	0	9	8	0	0.422	0.998	1.000
230	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(3), ARSD(3), ARSE(2), CYP11B1(4), CYP11B2(5), HSD11B1(2), HSD17B3(2), HSD17B8(1), HSD3B1(2), SRD5A1(1), STS(4), SULT1E1(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5)	15215028	48	44	48	9	4	15	5	10	14	0	0.163	0.998	1.000
231	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(6), EGFR(6), MAP3K1(3), MAPK14(3), NCOR2(14), RARA(1), RXRA(2)	9985932	35	33	32	8	7	6	6	8	8	0	0.346	0.998	1.000
232	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(10), HADH(1), HADHA(3), HSD17B4(1), NTAN1(2), SIRT1(2), SIRT2(2), VNN2(1)	6711713	24	14	24	6	1	6	6	7	4	0	0.311	0.998	1.000
233	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	CISH(5), IFNG(3), IFNGR1(3), JAK2(4), PTPRU(2), REG1A(1), STAT1(5)	5124734	23	20	23	7	0	7	2	8	6	0	0.691	0.998	1.000
234	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(2), EGF(6), EGFR(6), FOS(1), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1), STAT1(5), STAT3(4), STAT5A(2)	18638683	72	58	69	12	2	16	8	20	25	1	0.117	0.998	1.000
235	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), SDS(2)	6880346	25	16	25	6	0	5	4	11	5	0	0.404	0.998	1.000
236	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), DFFB(1), DIABLO(1)	7613601	27	23	26	6	3	9	1	5	9	0	0.457	0.998	1.000
237	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(1), HSD17B3(2), HSD17B4(1), HSD17B7(1), HSD3B1(2)	4531073	10	10	10	6	2	2	0	2	4	0	0.882	0.998	1.000
238	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(2), EPX(3), ESCO1(2), ESCO2(3), HPD(2), LPO(4), MAOA(1), MAOB(8), MPO(5), NAT6(1), PNPLA3(1), PRDX6(1), SH3GLB1(2), TAT(3), TPO(13)	19185495	58	47	58	8	3	14	8	19	14	0	0.0102	0.998	1.000
239	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(4), FUT9(4), GBGT1(3), GLA(1), HEXA(3), HEXB(1), ST3GAL1(1), ST3GAL2(1)	5613326	19	18	19	7	2	0	0	11	6	0	0.851	0.998	1.000
240	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(5), DLL1(2), FURIN(5), NOTCH1(7), PSEN1(2)	5601243	21	21	21	6	5	4	4	6	2	0	0.275	0.999	1.000
241	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(4), AASS(5)	3851709	11	11	11	4	0	3	2	4	2	0	0.787	0.999	1.000
242	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC3A(1), APOBEC3B(2), APOBEC3G(1), APOBEC4(2)	4083245	9	9	9	3	0	0	0	5	4	0	0.922	0.999	1.000
243	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), DCXR(1), GUSB(8), UCHL1(1), UCHL3(2), UGDH(2), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5)	9672739	32	25	31	8	0	7	1	7	17	0	0.808	0.999	1.000
244	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(3), CREB1(1), DAXX(1), HMGN1(1), HSPB1(1), HSPB2(1), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MEF2A(6), MEF2C(1), MEF2D(3), MKNK1(2), MYC(2), PLA2G4A(8), RIPK1(4), RPS6KA5(5), SHC1(3), STAT1(5), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1)	21268047	79	63	78	13	8	16	9	29	17	0	0.0367	0.999	1.000
245	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(7), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF5(1), GSK3B(3), PPP1CA(2)	6486048	19	19	19	5	0	10	0	3	6	0	0.345	0.999	1.000
246	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(3), CREBBP(6), DFFB(1), GZMA(3), GZMB(2), HMGB2(1), NME1(2), PRF1(4)	6005111	22	22	22	9	2	4	2	7	7	0	0.864	0.999	1.000
247	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), CDC42(3), PAK1(3), PDGFRA(5), PIK3R1(4), WASL(2)	6342551	25	22	25	6	2	8	5	4	6	0	0.324	0.999	1.000
248	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(5), CHAT(4), CHKA(1), PCYT1A(3), PDHA1(1), PDHA2(3)	3884724	17	16	17	7	2	2	1	9	3	0	0.767	0.999	1.000
249	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	CISH(5), JAK2(4), JAK3(7), PIAS3(1), PTPRU(2), REG1A(1)	6660306	20	17	20	5	3	5	3	5	4	0	0.396	0.999	1.000
250	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(1), PAH(2), TAT(3)	4863921	9	9	9	6	0	2	3	0	4	0	0.970	0.999	1.000
251	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(2), MBTPS1(4), MBTPS2(1), SCAP(5), SREBF1(3), SREBF2(3)	7113483	20	18	20	5	3	3	2	4	7	1	0.404	0.999	1.000
252	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP54(1), SRP68(1), SRP72(3), SRPR(2)	4184650	9	6	9	2	1	3	0	1	4	0	0.763	0.999	1.000
253	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(2), FUT1(4), FUT9(4), GBGT1(3), GLA(1), HEXA(3), HEXB(1), ST3GAL1(1), ST3GAL2(1)	5946789	22	21	22	7	2	2	0	12	6	0	0.760	0.999	1.000
254	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(11), CD38(3), ENPP1(1), ENPP3(4), NMNAT1(2), NNT(4), NT5E(1), NT5M(2)	8252110	28	24	27	7	0	15	3	6	4	0	0.323	0.999	1.000
255	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	CNR1(3), CNR2(1), DNMT1(2), MTNR1A(2), MTNR1B(3), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2)	6573798	20	19	20	5	1	5	4	9	1	0	0.267	0.999	1.000
256	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(4), FUT3(2), FUT5(1)	2859652	7	7	7	4	2	0	1	3	1	0	0.878	0.999	1.000
257	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), LTB4R(1), P2RY1(4), P2RY2(1), P2RY6(1)	3179701	13	13	13	6	0	1	2	8	2	0	0.843	0.999	1.000
258	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(10), GNB1(2), PPP2CA(2), PRKAA1(4), PRKAB2(1), PRKACB(2), PRKACG(2), PRKAG2(3), PRKAR1B(1), PRKAR2B(3)	8865671	35	31	32	8	7	8	1	13	6	0	0.451	0.999	1.000
259	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(3), ACO1(6), ACO2(3), ACSS1(2), ACSS2(1), FH(3), IDH2(4), MDH1(1), SUCLA2(2)	7016875	25	24	25	7	2	4	5	7	7	0	0.593	0.999	1.000
260	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(2), EIF2B5(1), EIF2S2(1), EIF2S3(1), GSK3B(3), IGF1R(11), INPPL1(1), PDK2(1), PDPK1(1), PIK3R1(4), PPP2CA(2), RPS6(2), RPS6KB1(2)	9784107	32	25	31	6	1	7	2	10	12	0	0.228	0.999	1.000
261	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(2), AKT2(3), AKT3(2), CASP9(1), CDC42(3), KDR(7), MAP2K2(2), MAPK1(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPKAPK2(1), MAPKAPK3(1), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NOS3(9), NRAS(3), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCG1(7), PLCG2(7), PPP3CA(3), PPP3CB(3), PRKCA(1), PRKCG(4), PTGS2(3), PTK2(9), PXN(2), RAC3(1), RAF1(2), SH2D2A(2), SPHK1(7), SPHK2(3), SRC(3), VEGFA(1)	40160434	173	109	166	27	17	38	17	51	50	0	0.00115	0.999	1.000
262	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(1), HADHA(3), HADHB(4), HSD17B4(1), PPT1(2), PPT2(3)	4844496	17	15	16	6	2	5	2	6	2	0	0.609	0.999	1.000
263	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(10), GNA12(1), PRKACB(2), PRKACG(2), PRKAR2B(3)	5689819	18	16	18	6	0	7	0	6	5	0	0.725	0.999	1.000
264	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(3), CTH(2), DNMT1(2), DNMT3A(9), DNMT3B(2), MARS(6), MAT1A(4), MTAP(2), MTFMT(1), MTR(3), SRM(2), TAT(3)	11786215	39	34	38	8	5	6	0	13	15	0	0.358	0.999	1.000
265	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(3), CTH(2), DNMT1(2), DNMT3A(9), DNMT3B(2), MARS(6), MAT1A(4), MTR(3)	9864088	31	27	31	6	4	5	0	12	10	0	0.386	0.999	1.000
266	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(2), UGP2(3)	2850554	6	6	6	4	0	2	0	2	2	0	0.959	0.999	1.000
267	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(2), AKT2(3), AKT3(2), FCER1A(1), FYN(1), GAB2(5), IL4(1), IL5(1), LAT(1), LCP2(5), LYN(1), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MS4A2(3), NRAS(3), PDK1(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCG1(7), PLCG2(7), PRKCA(1), RAC3(1), RAF1(2), SOS1(8), SOS2(4), SYK(1), TNF(1), VAV1(3), VAV3(8)	38960851	149	97	144	20	10	30	15	47	46	1	0.00147	1.000	1.000
268	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(2), AKT2(3), AKT3(2), BCL2(1), BCR(2), BLNK(3), CD19(2), CD22(5), CD81(2), CR2(9), CSK(1), DAG1(1), FLOT1(3), GSK3A(1), GSK3B(3), ITPR1(15), ITPR2(11), ITPR3(11), LYN(1), MAP4K1(1), MAPK1(3), NFATC1(2), NFATC2(7), NR0B2(4), PDK1(1), PIK3CD(5), PIK3R1(4), PLCG2(7), PPP1R13B(4), PPP3CA(3), PPP3CB(3), PTPRC(8), RAF1(2), SHC1(3), SOS1(8), SOS2(4), SYK(1), VAV1(3)	40504673	151	110	150	20	16	37	21	51	25	1	6.03e-05	1.000	1.000
269	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3G(1), IFNG(3), IL2RA(1), IL4(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TOB1(4), TOB2(1)	6064526	20	19	20	7	1	5	1	8	5	0	0.821	1.000	1.000
270	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS3(1), DHRS7(1), HSD3B7(1), PON1(1), PON2(1), PON3(3), RDH11(1), RDH13(1), RDH14(1)	5002837	12	11	12	4	2	4	0	5	1	0	0.718	1.000	1.000
271	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	6	IL13RA1(2), IL13RA2(2), IL4R(1), JAK2(4), TYK2(1)	4537383	10	9	10	4	1	1	0	3	5	0	0.903	1.000	1.000
272	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	6	IL13RA1(2), IL13RA2(2), IL4R(1), JAK2(4), TYK2(1)	4537383	10	9	10	4	1	1	0	3	5	0	0.903	1.000	1.000
273	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(3), DFFB(1), GZMB(2), HMGB1(2), HMGB2(1), TOP2A(4), TOP2B(6)	5978187	19	18	19	9	1	2	3	7	6	0	0.960	1.000	1.000
274	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	23	AKT1(2), APC(12), CCND1(1), DVL1(3), FZD1(2), GJA1(1), GNAI1(4), GSK3B(3), IRAK1(5), LBP(3), LEF1(2), LY96(1), MYD88(1), NFKB1(3), PDPK1(1), PIK3R1(4), PPP2CA(2), RELA(4), TIRAP(2), TLR4(5), WNT1(2)	14669599	63	50	63	14	1	18	7	16	20	1	0.203	1.000	1.000
275	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ARG2(1), ASL(1), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), GAMT(1), GATM(4), GLUD1(3), NAGS(1), OAT(2), ODC1(3), PYCR1(1), SMS(1)	10612390	38	30	38	9	2	10	8	7	11	0	0.234	1.000	1.000
276	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), MIOX(1), UGDH(2)	4829851	10	8	10	3	0	3	0	5	2	0	0.676	1.000	1.000
277	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(3), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP3A4(1), CYP3A43(1), CYP3A5(4), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), RDH11(1), RDH13(1), RDH14(1)	13738699	49	44	47	10	6	10	3	15	15	0	0.150	1.000	1.000
278	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(9), CDC25B(2), CDC25C(3), CHEK1(5), MYT1(2), WEE1(2)	8496421	23	22	23	5	2	2	2	10	7	0	0.503	1.000	1.000
279	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(2), EIF4A2(3), EIF4G1(7), EIF4G2(4), EIF4G3(6), GHR(3), IRS1(3), MAPK1(3), MAPK14(3), MKNK1(2), PDK2(1), PDPK1(1), PIK3R1(4), PRKCA(1), RPS6KB1(2)	14325091	45	33	43	9	2	10	10	6	16	1	0.191	1.000	1.000
280	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(9), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), DFFB(1), GZMB(2), LMNA(2), LMNB2(2), PRF1(4)	10929741	37	31	37	8	1	12	1	10	13	0	0.509	1.000	1.000
281	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(1), SNCA(1), SNCAIP(2), UBE2E2(1), UBE2L3(1)	3503895	9	9	9	7	0	2	2	4	1	0	0.964	1.000	1.000
282	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA1(1), FUCA2(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), MAN2B1(2), MAN2B2(3), MAN2C1(5), MANBA(1), NEU1(2), NEU2(4), NEU3(2), NEU4(2)	11833282	38	33	37	9	5	9	6	10	8	0	0.215	1.000	1.000
283	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	7	IFNAR1(2), IFNAR2(1), IFNB1(2), STAT1(5), TYK2(1)	4797141	11	11	11	4	1	4	1	4	1	0	0.675	1.000	1.000
284	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), DDOST(1), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), RPN1(1), RPN2(2), ST6GAL1(1)	11430884	34	28	34	7	3	9	2	12	8	0	0.235	1.000	1.000
285	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), PHPT1(1), TPK1(2)	3584135	11	10	11	5	1	1	0	7	2	0	0.944	1.000	1.000
286	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(3), CFTR(3), GNAS(10), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), SLC9A3R1(1)	7584063	30	26	27	7	6	9	2	10	3	0	0.379	1.000	1.000
287	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(1), CAPNS1(1), EP300(11), HDAC2(3), MEF2D(3), NFATC1(2), NFATC2(7), PPP3CA(3), PPP3CB(3), PRKCA(1), SYT1(2)	13683169	42	35	40	9	4	8	2	19	9	0	0.310	1.000	1.000
288	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(3), GAD1(5), GAD2(1), GGT1(1)	3303113	11	11	11	5	2	2	0	5	2	0	0.864	1.000	1.000
289	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(8), EIF2S2(1), NFKB1(3), NFKBIA(2), RELA(4)	5268940	18	15	18	7	0	5	3	6	4	0	0.856	1.000	1.000
290	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1R(5), TNF(1)	3615279	9	8	9	6	3	0	1	3	2	0	0.934	1.000	1.000
291	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), CASP8(1), FADD(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1)	4755756	11	11	11	5	0	4	1	3	3	0	0.873	1.000	1.000
292	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(11), DCT(3), DDC(2), GSTZ1(2), HGD(4), HPD(2), MAOA(1), MAOB(8), TAT(3), TH(1), TPO(13), TYR(5)	17964727	74	61	74	14	4	18	8	25	19	0	0.0641	1.000	1.000
293	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1)	7522765	21	20	21	6	0	3	2	8	8	0	0.679	1.000	1.000
294	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), NCK1(1), NCKAP1(3), NTRK1(5), PSMA7(3), WASF1(1), WASF2(2), WASF3(2), WASL(2)	8667168	28	26	27	7	3	13	5	4	3	0	0.203	1.000	1.000
295	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(3), IL22(1), IL22RA1(1), JAK2(4), JAK3(7), SOCS3(1), STAT1(5), STAT3(4), STAT5A(2), STAT5B(1), TYK2(1)	9416156	30	27	29	7	4	6	3	13	4	0	0.394	1.000	1.000
296	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(6), ACO2(3), CS(4), DLD(4), DLST(1), FH(3), IDH2(4), IDH3G(2), MDH1(1), PC(3), PCK1(6), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1)	11162775	44	39	43	11	3	8	8	9	15	1	0.387	1.000	1.000
297	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(2), CYP2A6(3), CYP2A7(4), XDH(8)	4490080	17	16	17	5	0	7	0	8	2	0	0.803	1.000	1.000
298	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	EPHB2(4), F2(2), F2RL3(1), JUN(2), MAP2K5(1), MAPK1(3), MAPK7(3), MAPK8(1), MYEF2(3), PLD1(4), PLD2(3), PLD3(4), PTK2(9), RAF1(2), RASAL1(4), SRC(3), VAV1(3)	14845854	52	39	52	8	2	15	7	23	5	0	0.0335	1.000	1.000
299	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(2), GPI(1), HK1(3), PFKL(1), PKLR(3), TPI1(1)	5148143	12	12	12	5	1	2	1	5	3	0	0.711	1.000	1.000
300	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(4), MDH1(1), ME1(1), PC(3), PDHA1(1), SLC25A1(3)	5180489	16	14	16	8	2	4	2	4	4	0	0.916	1.000	1.000
301	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	29	A1BG(3), AKT1(2), AKT2(3), AKT3(2), DAPP1(1), GSK3A(1), GSK3B(3), IARS(5), PDK1(1), PPP1R13B(4), RPS6KA1(1), RPS6KA2(5), RPS6KB1(2), SHC1(3), SOS1(8), SOS2(4), YWHAE(1), YWHAZ(1)	17446072	50	39	49	9	7	13	8	11	10	1	0.0786	1.000	1.000
302	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(2), CREB1(1), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAPK1(3), MAPK14(3), NFKB1(3), PIK3R1(4), RELA(4), SP1(2)	8867060	31	23	31	7	1	6	5	8	11	0	0.416	1.000	1.000
303	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), IL4(1), IL5(1), JUNB(1), MAP2K3(2), MAPK14(3), NFATC1(2), NFATC2(7), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3)	6995965	26	24	26	8	2	5	2	11	6	0	0.744	1.000	1.000
304	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), IDS(1), IDUA(1), LCT(6), NAGLU(3)	8475616	27	25	25	8	2	4	5	7	9	0	0.385	1.000	1.000
305	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), FOS(1), JAK2(4), PTPN6(2), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1)	10112812	25	24	25	5	3	3	4	10	4	1	0.320	1.000	1.000
306	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(2), GPT(1), LDHA(1), LDHB(1), LDHC(1), MAPK14(3), NCL(6)	5102549	18	14	17	7	2	3	1	8	4	0	0.851	1.000	1.000
307	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(4), ABCG2(2), BCHE(2), CES1(3), CES2(2), CYP3A4(1), CYP3A5(4), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1)	12817743	32	28	32	7	0	11	3	9	9	0	0.274	1.000	1.000
308	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(2), CARS2(1), CTH(2), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), MPST(1), SDS(2), SULT1C2(1), SULT1C4(1), SULT4A1(1)	7113624	18	17	18	7	0	6	2	5	5	0	0.838	1.000	1.000
309	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), DPYD(6), DPYS(1), ENPP1(1), ENPP3(4), PANK1(1), PANK2(2), PANK4(4), PPCS(1), UPB1(1), VNN1(1)	9912491	25	20	25	5	2	8	4	9	2	0	0.200	1.000	1.000
310	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(3), CYP4F2(1), CYP4F3(2), EPX(3), GGT1(1), LPO(4), MPO(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PRDX1(1), PRDX2(2), PRDX6(1), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(3), TPO(13)	16097893	62	51	60	13	10	8	8	19	17	0	0.0953	1.000	1.000
311	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	AKT1(2), APC(12), ASAH1(2), CAMP(1), DAG1(1), EPHB2(4), GNAI1(4), GNAQ(1), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), PITX2(1), PTX3(1), RHO(3), RYR1(31)	25508956	106	80	104	18	14	23	5	40	23	1	0.0238	1.000	1.000
312	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(2), CTH(2), LDHA(1), LDHB(1), LDHC(1), MPST(1)	3802812	8	8	8	4	0	5	0	2	1	0	0.858	1.000	1.000
313	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(5), AKT1(2), ASAH1(2), GNAI1(4), GNB1(2), ITGAV(3), ITGB3(5), MAPK1(3), PDGFA(2), PDGFRA(5), PIK3R1(4), PLCB1(8), PRKCA(1), PTK2(9), SMPD1(4), SMPD2(4), SPHK1(7), SRC(3)	14153266	73	56	71	17	2	22	5	23	21	0	0.329	1.000	1.000
314	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	FCER1A(1), FOS(1), JUN(2), LYN(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAPK1(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PAK2(3), PIK3R1(4), PLA2G4A(8), PLCG1(7), PPP3CA(3), PPP3CB(3), RAF1(2), SHC1(3), SOS1(8), SYK(1), SYT1(2), VAV1(3)	22924318	83	64	81	15	8	14	10	26	24	1	0.0502	1.000	1.000
315	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(1), ITGAL(5), ITGAM(6), ITGB2(8), SELE(1)	6042336	25	23	24	9	2	9	1	8	5	0	0.855	1.000	1.000
316	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(4), CYP7A1(1), HADHB(4), SOAT2(1), SRD5A1(1)	13154919	40	35	40	9	3	10	4	17	6	0	0.201	1.000	1.000
317	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT2(1), B4GALT3(2), CHST2(3), CHST6(2), FUT8(2), ST3GAL1(1), ST3GAL2(1)	6818649	15	15	15	5	3	2	1	5	4	0	0.685	1.000	1.000
318	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), CAMP(1), CREB1(1), CREB5(2), MAPK1(3), RAF1(2), SNX13(2), SRC(3), TERF2IP(1)	6611335	17	17	17	5	2	2	2	7	4	0	0.681	1.000	1.000
319	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(3), HK2(3), HK3(5), IMPA1(2), IMPA2(2), ISYNA1(1), PGM1(1), PGM3(2), TGDS(1)	6733517	20	20	20	9	0	3	3	10	4	0	0.800	1.000	1.000
320	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GPX7(1), GSR(3), GSS(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), IDH2(4), MGST2(1), OPLAH(5)	12870047	32	28	32	7	4	6	3	12	7	0	0.221	1.000	1.000
321	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(3), HK2(3), HK3(5), IMPA1(2), PGM1(1), PGM3(2), TGDS(1)	5895828	17	17	17	9	0	3	3	8	3	0	0.852	1.000	1.000
322	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(9), ATM(9), ATR(15), BAI1(5), BAX(3), CASP3(3), CASP8(1), CASP9(1), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNG1(1), CD82(3), CDK6(1), CHEK1(5), CHEK2(5), DDB2(3), EI24(2), FAS(3), GADD45G(1), GTSE1(3), IGFBP3(2), MDM2(1), MDM4(1), PPM1D(2), RCHY1(1), RFWD2(4), RPRM(1), SERPINE1(1), SESN1(1), SESN2(3), SESN3(2), SIAH1(4), STEAP3(2), THBS1(6), TNFRSF10B(2), TP73(2), TSC2(12), ZMAT3(1)	36092414	135	95	132	22	11	29	11	47	36	1	0.00753	1.000	1.000
323	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(1), AGT(1), AGTR1(2), ANPEP(3), CPA3(3), CTSA(1), CTSG(1), ENPEP(2), LNPEP(6), MME(6), THOP1(3)	11883066	33	26	32	9	0	8	2	9	14	0	0.563	1.000	1.000
324	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	21	ABL1(2), ATM(9), ATR(15), CCNA1(3), CCND1(1), CCNE1(1), CDK6(1), CDKN1B(5), CDKN2B(1), E2F1(3), GSK3B(3), SKP2(1), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2)	15080031	54	45	53	10	2	9	2	28	12	1	0.253	1.000	1.000
325	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	CHUK(8), CRADD(1), IKBKB(4), JUN(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP4K2(4), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1)	14227411	49	38	49	10	3	11	6	14	15	0	0.342	1.000	1.000
326	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ENPP1(1), ENPP3(4), FLAD1(2), RFK(1), TYR(5)	5519999	24	20	24	8	0	6	5	9	4	0	0.674	1.000	1.000
327	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(3), NAT6(1), PNPLA3(1), SH3GLB1(2)	9099240	12	11	12	3	1	3	1	6	1	0	0.415	1.000	1.000
328	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), XYLT1(3), XYLT2(1)	3940176	11	11	11	9	0	3	2	5	1	0	0.994	1.000	1.000
329	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), XYLT1(3), XYLT2(1)	3940176	11	11	11	9	0	3	2	5	1	0	0.994	1.000	1.000
330	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), SLC33A1(2), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(2), ST6GALNAC5(3), ST8SIA5(2)	9218875	26	24	25	8	1	5	8	5	7	0	0.421	1.000	1.000
331	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), FADD(1), FAS(3), GZMB(2), JUN(2), MAP2K4(4), MAP3K1(3), MAPK10(3), MCL1(2), MDM2(1), MYC(2), NFKB1(3), NFKBIA(2), PARP1(5), PRF1(4), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(1), TRAF1(1)	20993648	75	58	72	16	5	22	8	21	19	0	0.222	1.000	1.000
332	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), ESRRA(2), HDAC5(4), MEF2A(6), MEF2C(1), MEF2D(3), PPARA(3), PPP3CA(3), PPP3CB(3), SLC2A4(2), SYT1(2)	12013009	43	36	42	10	4	9	2	21	7	0	0.325	1.000	1.000
333	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(3), GPR161(4), GPR34(1), GPR45(1), GPR65(2), GPR68(3)	5502944	16	16	16	6	3	3	1	8	1	0	0.768	1.000	1.000
334	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(10), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), ATP7A(6), ATP7B(3), COX10(1), COX5A(2), COX5B(2), COX6B1(2), NDUFA10(1), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFV2(2), SDHA(2), SDHB(1), SHMT1(2), UQCRB(1)	21624045	74	61	73	14	2	25	6	27	14	0	0.0693	1.000	1.000
335	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(4), ALOX5(3), GGT1(1), PLA2G6(3), PTGIS(2), PTGS1(2), PTGS2(3)	8902094	18	17	18	7	8	0	0	5	5	0	0.744	1.000	1.000
336	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(1), CAPNS1(1), CXCR3(3), EGF(6), EGFR(6), ITGA1(5), MAPK1(3), MYLK(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTK2(9), PXN(2), TLN1(10)	18934784	60	49	59	11	3	21	5	17	14	0	0.122	1.000	1.000
337	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ACADM(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), DPYD(6), DPYS(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), HIBCH(6), SMS(1), SRM(2), UPB1(1)	15182787	52	37	50	12	3	12	6	22	9	0	0.156	1.000	1.000
338	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(5), CREB1(1), FOS(1), GNAI1(4), GNAQ(1), GNAS(10), GNB1(2), JUN(2), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), RAF1(2), SYT1(2)	19043749	70	54	65	15	11	17	5	24	13	0	0.207	1.000	1.000
339	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(2), ADRBK2(2), ARRB2(1), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CLCA1(8), CLCA2(10), CLCA4(2), CNGA4(3), CNGB1(4), GNAL(2), GUCA1A(1), PDE1C(9), PRKACA(2), PRKACB(2), PRKACG(2), PRKG1(6), PRKG2(4), PRKX(3)	16758464	76	51	75	17	6	22	7	20	19	2	0.134	1.000	1.000
340	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRA(1), HLA-DRB1(1), IFNG(3), IFNGR1(3), IFNGR2(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18(2), IL18R1(2), IL2RA(1), IL4(1), IL4R(1)	7085266	34	28	34	10	0	8	4	15	7	0	0.541	1.000	1.000
341	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), ASRGL1(1), CA1(1), CA14(1), CA4(2), CA5A(1), CA5B(1), CA6(1), CA8(1), CA9(7), CPS1(12), CTH(2), GLS(4), GLS2(1), GLUD1(3), GLUD2(5), GLUL(1)	11875556	47	41	47	12	3	12	12	12	8	0	0.226	1.000	1.000
342	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	10	ARNT(2), EPOR(1), GRIN1(5), HIF1A(3), JAK2(4), NFKB1(3), NFKBIA(2), RELA(4)	7231261	24	22	23	9	0	4	2	12	6	0	0.952	1.000	1.000
343	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(3), ARSD(3), ARSE(2), CYP11B1(4), CYP11B2(5), CYP19A1(1), HEMK1(3), HSD11B1(2), HSD17B3(2), HSD17B7(1), HSD17B8(1), HSD3B1(2), LCMT2(3), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SRD5A1(1), STS(4), SULT1E1(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5), WBSCR22(2)	27278284	87	72	86	16	8	23	9	24	22	1	0.0910	1.000	1.000
344	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(4), AASS(5), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), ATP6V0C(2), BBOX1(3), DLST(1), DOT1L(7), ECHS1(2), EHHADH(10), EHMT1(4), EHMT2(5), GCDH(1), HADHA(3), PLOD1(1), PLOD2(6), PLOD3(1), SDS(2), SHMT1(2), SHMT2(4)	20854876	80	56	80	17	3	20	10	26	21	0	0.144	1.000	1.000
345	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(3), GSS(1), NFKB1(3), NOX1(3), RELA(4), TNF(1), XDH(8)	5698410	23	20	23	8	0	7	3	9	4	0	0.775	1.000	1.000
346	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(12), ASAH1(2), CAMP(1), CASP3(3), CREB1(1), CREB5(2), DAG1(1), EPHB2(4), FOS(1), GNAQ(1), ITPKA(1), ITPKB(4), JUN(2), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3)	16333098	54	48	54	12	3	8	6	18	18	1	0.405	1.000	1.000
347	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), AOC2(2), AOC3(1), DDC(2), HARS(1), HDC(4), MAOA(1), MAOB(8), PRPS1(1)	13790583	30	24	30	6	2	6	2	12	8	0	0.243	1.000	1.000
348	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(8), APOA1(2), APOA4(2), APOE(1), CETP(2), CYP7A1(1), DGAT1(4), HMGCR(6), LCAT(3), LDLR(2), LIPC(2), LPL(1), LRP1(19)	15296221	53	45	53	12	5	12	9	19	6	2	0.226	1.000	1.000
349	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(3), CD79B(1), FOS(1), JUN(2), LYN(1), MAP3K1(3), MAPK14(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), RAF1(2), SHC1(3), SOS1(8), SYK(1), SYT1(2), VAV1(3)	21438349	66	53	64	13	8	14	10	22	11	1	0.0834	1.000	1.000
350	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(3), AKT3(2), BCR(2), BLNK(3), CD19(2), CSK(1), DAG1(1), EPHB2(4), ITPKA(1), ITPKB(4), LYN(1), MAP2K2(2), MAPK1(3), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PIK3CD(5), PIK3R1(4), PLCG2(7), PPP1R13B(4), RAF1(2), SERPINA4(2), SHC1(3), SOS1(8), SOS2(4), SYK(1), VAV1(3)	28956559	88	67	88	15	7	27	12	25	16	1	0.0283	1.000	1.000
351	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(2), CABIN1(5), CAMK1(1), CAMK1G(2), HDAC5(4), IGF1R(11), INS(1), INSR(4), MAP2K6(2), MAPK14(3), MAPK7(3), MEF2A(6), MEF2C(1), MEF2D(3), MYOD1(1), NFATC1(2), NFATC2(7), PIK3R1(4), PPP3CA(3), PPP3CB(3), SYT1(2)	18711182	70	50	70	15	8	12	9	26	15	0	0.143	1.000	1.000
352	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREB1(1), CREBBP(6), EP300(11), NCOA3(10), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RARA(1), RXRA(2)	11648855	39	32	37	10	0	12	2	14	11	0	0.623	1.000	1.000
353	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(2), APC(12), AR(14), ASAH1(2), CAMP(1), CCL13(1), CCL15(1), CCL16(1), DAG1(1), EGFR(6), GNA15(1), GNAI1(4), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), MAPK10(3), MAPK14(3), PHKA2(3), PIK3CD(5), PIK3R1(4), PITX2(1), PTX3(1), RAF1(2), SRC(3)	29455028	120	85	112	22	10	28	11	46	24	1	0.0399	1.000	1.000
354	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(2), AKT2(3), AKT3(2), BRD4(6), CBL(4), CDC42(3), FLOT1(3), GSK3A(1), GSK3B(3), INPPL1(1), IRS1(3), IRS2(2), IRS4(7), LNPEP(6), MAPK1(3), PARD3(3), PDK1(1), PIK3CD(5), PIK3R1(4), RAF1(2), RPS6KA1(1), RPS6KA2(5), RPS6KB1(2), SERPINB6(2), SHC1(3), SLC2A4(2), SORBS1(1), SOS1(8), SOS2(4), YWHAE(1), YWHAZ(1)	30595599	94	78	93	17	10	20	17	25	21	1	0.0129	1.000	1.000
355	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(8), IFNG(3), IKBKB(4), IL4(1), JUN(2), MAP3K1(3), MAP3K5(1), MAP4K5(7), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), RELA(4)	11230841	43	33	42	11	1	13	5	14	10	0	0.480	1.000	1.000
356	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB1(1), CREB5(2), DUSP4(1), DUSP6(2), DUSP9(1), EEF2K(1), MAP2K2(2), MAP3K8(1), MAPK1(3), MKNK1(2), MKNK2(3), MOS(2), NFKB1(3), RAP1A(2), RPS6KA1(1), RPS6KA2(5), SHC1(3), SOS1(8), SOS2(4), TRAF3(1)	16146890	48	40	48	10	10	11	8	12	6	1	0.112	1.000	1.000
357	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7), GPHN(6), SRC(3), UBQLN1(3)	7219873	42	36	39	13	1	8	1	21	11	0	0.808	1.000	1.000
358	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	B2M(1), CANX(1), CD4(1), CD74(1), CD8A(1), CD8B(1), CIITA(6), CREB1(1), CTSB(2), CTSS(1), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOB(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(3), HLA-G(3), HSP90AA1(5), HSP90AB1(4), HSPA5(1), IFI30(2), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), KIR2DL3(3), KLRC1(1), KLRC3(2), KLRC4(1), NFYA(2), NFYB(1), NFYC(2), PDIA3(1), PSME1(1), RFX5(3), RFXAP(1), TAP1(2)	25906683	90	71	89	19	4	13	9	36	28	0	0.321	1.000	1.000
359	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(1), CAMK1G(2), FPR1(1), GNA15(1), GNB1(2), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAPK1(3), MAPK14(3), NCF1(1), NCF2(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKBIA(2), PAK1(3), PIK3C2G(7), PLCB1(8), PPP3CA(3), PPP3CB(3), RAF1(2), RELA(4), SYT1(2)	22214157	79	58	78	17	6	17	10	32	14	0	0.201	1.000	1.000
360	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(6), EP300(11), ESR1(6), MAPK1(3), PELP1(5), SRC(3)	8573034	34	29	33	10	1	12	3	12	6	0	0.469	1.000	1.000
361	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(2), BCL2(1), EGFR(6), IGF1R(11), MYC(2), POLR2A(7), PPP2CA(2), PRKCA(1), TEP1(13), TERF1(5), TERT(2), TNKS(3), XRCC5(4)	14249630	59	49	58	14	2	16	3	21	17	0	0.505	1.000	1.000
362	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(14), ESR1(6), ESR2(1), ESRRA(2), HNF4A(3), NPM1(1), NR0B1(3), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(4), NR1I2(3), NR1I3(2), NR2C2(2), NR2E1(1), NR2F1(2), NR2F2(4), NR2F6(1), NR3C1(3), NR4A1(3), NR4A2(6), NR5A1(2), NR5A2(3), PGR(5), PPARA(3), PPARG(1), RARA(1), RARB(1), RARG(4), ROR1(3), RORA(4), RORC(1), RXRA(2), RXRB(8), RXRG(2)	24247961	108	77	98	23	10	22	12	41	23	0	0.104	1.000	1.000
363	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(1), AGTR1(2), COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6)	14520565	45	37	44	13	1	8	7	16	13	0	0.307	1.000	1.000
364	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(8), DUSP1(1), IKBKAP(5), IKBKB(4), MAP3K1(3), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNFAIP3(1), TNFRSF1B(1), TRAF1(1), TRAF3(1)	13148977	38	30	38	9	0	12	7	11	8	0	0.419	1.000	1.000
365	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(5), ATG7(2), BECN1(2), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNG(3), INS(1), PIK3C3(2), PIK3R4(4), PRKAA1(4), ULK1(3), ULK2(5), ULK3(1)	12117981	51	40	50	12	1	13	4	23	10	0	0.401	1.000	1.000
366	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(2), GTF2B(3), GTF2E1(3), GTF2F1(1), NCOA1(5), NCOA2(5), NCOA3(10), NCOR2(14), POLR2A(7), RARA(1), RXRA(2), TBP(1)	14264377	57	46	54	15	6	12	8	13	18	0	0.308	1.000	1.000
367	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(12), CDH1(7), CREBBP(6), EP300(11), MAP3K7(3), SKIL(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1)	14442911	49	43	47	12	1	13	3	19	12	1	0.360	1.000	1.000
368	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(2), AKT2(3), AKT3(2), ANKRD6(3), APC(12), AXIN2(6), CER1(1), CSNK1A1(2), DACT1(3), DKK1(1), DKK2(4), DKK3(4), DVL1(3), GSK3A(1), GSK3B(3), LRP1(19), MVP(2), NKD1(2), NKD2(3), PIN1(2), PSEN1(2), PTPRA(4), SENP2(3), WIF1(6)	21291783	93	69	90	20	2	21	11	33	24	2	0.216	1.000	1.000
369	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(8), FADD(1), IKBKB(4), IL1R1(4), IRAK1(5), MAP3K1(3), MAP3K7(3), MYD88(1), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TLR4(5), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2)	14286427	53	41	53	12	0	18	7	19	9	0	0.259	1.000	1.000
370	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(11), BST1(1), CD38(3), ENPP1(1), ENPP3(4), NADK(3), NMNAT1(2), NMNAT3(1), NNT(4), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), NUDT12(3)	12171927	40	33	39	10	0	16	6	10	7	1	0.298	1.000	1.000
371	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	7	IFNAR1(2), IFNB1(2), PTPRU(2), REG1A(1), STAT1(5), TYK2(1)	5729432	13	12	13	5	1	5	1	5	1	0	0.767	1.000	1.000
372	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(1), CDC42(3), DLD(4), DUSP4(1), DUSP8(2), GAB1(3), IL1R1(4), JUN(2), MAP2K4(4), MAP2K5(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK10(3), MAPK7(3), MAPK8(1), MAPK9(3), MYEF2(3), NFATC3(4), NR2C2(2), PAPPA(5), SHC1(3), TRAF6(2), ZAK(3)	27986749	94	69	94	18	9	20	11	29	24	1	0.0433	1.000	1.000
373	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(2), ATM(9), BRCA1(9), CHEK1(5), CHEK2(5), JUN(2), MAPK8(1), MDM2(1), NFKB1(3), NFKBIA(2), RAD50(6), RAD51(2), RBBP8(3), RELA(4), TP73(2)	15983760	56	44	56	12	4	10	6	20	15	1	0.332	1.000	1.000
374	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), CMBL(2), CYP3A4(1), CYP3A43(1), CYP3A5(4), DHRS1(1), DHRS3(1), DHRS7(1), PON1(1), PON2(1), PON3(3)	10405360	35	32	35	10	1	6	4	16	8	0	0.660	1.000	1.000
375	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(1), AKT1(2), ANGPTL2(1), DAG1(1), DGKA(4), GCA(1), ITGA9(5), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), MAPK1(3), NR1I3(2), PAK1(3), PDE3A(8), PDE3B(2), PIK3C2G(7), PIK3CD(5), PIK3R1(4), PSME1(1), RIPK3(6), SGCB(1), VASP(2)	26916321	101	73	100	19	11	27	9	37	17	0	0.0439	1.000	1.000
376	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	FYN(1), LRP8(3), RELN(12), VLDLR(2)	7810921	18	18	18	9	1	5	4	6	2	0	0.898	1.000	1.000
377	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6), F10(3), F11(1), F12(1), F2(2), F2R(1), F5(7), F8(5), FGA(12), FGB(3), KLKB1(3), PROC(2), SERPINC1(2), SERPING1(3)	25380265	86	70	84	20	2	21	15	28	20	0	0.0697	1.000	1.000
378	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GSS(1), GSTA2(1), GSTA4(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), IDH2(4), MGST2(1)	10388436	21	19	21	6	2	5	1	8	5	0	0.577	1.000	1.000
379	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(9), ATR(15), BRCA1(9), CCNB1(2), CDC25B(2), CDC25C(3), CDC34(1), CHEK1(5), CHEK2(5), EP300(11), MDM2(1), MYT1(2), PRKDC(6), RPS6KA1(1), WEE1(2)	23640298	74	62	73	14	4	10	8	31	19	2	0.132	1.000	1.000
380	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MAPKAPK5(3), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PIK3CD(5), PIK3R1(4), SYT1(2), TRAF3(1), TRAF5(2), TRAF6(2)	19406303	52	42	52	11	3	11	4	15	19	0	0.323	1.000	1.000
381	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(6), EP300(11), FYN(1), IL2RG(1), IL7(1), IL7R(1), JAK3(7), LCK(4), NMI(2), PIK3R1(4), PTK2B(5), STAT5A(2), STAT5B(1)	13327373	47	40	46	12	3	14	2	16	12	0	0.396	1.000	1.000
382	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(2), AKT2(3), AKT3(2), BCL10(1), BLNK(3), CARD11(11), CD19(2), CD22(5), CD79B(1), CD81(2), CHUK(8), CR2(9), FOS(1), GSK3B(3), IKBKB(4), JUN(2), LILRB3(3), LYN(1), MALT1(3), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKB2(2), NFKBIA(2), NRAS(3), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG2(7), PPP3CA(3), PPP3CB(3), PTPN6(2), RAC3(1), RASGRP3(1), SYK(1), VAV1(3), VAV3(8)	41316928	153	102	151	26	11	44	19	46	33	0	0.00302	1.000	1.000
383	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	12	APC(12), CREBBP(6), DVL1(3), EP300(11), FZD1(2), GSK3B(3), LDB1(3), LEF1(2), PITX2(1), TRRAP(9), WNT1(2)	16858006	54	47	53	14	3	18	4	17	11	1	0.338	1.000	1.000
384	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(11), DCT(3), DDC(2), ECH1(1), ESCO1(2), ESCO2(3), GSTZ1(2), HEMK1(3), HGD(4), HPD(2), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), NAT6(1), PNPLA3(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(3), TH(1), TPO(13), TYR(5), WBSCR22(2)	33422580	113	87	113	22	8	28	14	37	25	1	0.0245	1.000	1.000
385	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ACADL(2), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), AOC2(2), AOC3(1), DPYD(6), DPYS(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), SDS(2), SMS(1), UPB1(1)	16317750	49	35	49	12	3	10	6	20	10	0	0.303	1.000	1.000
386	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1B(1), ADRA1D(4), ADRA2C(1), ADRB2(3), ADRB3(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), DRD1(1), DRD2(4), DRD3(2), DRD5(1), HRH1(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5)	14507373	58	49	56	16	8	8	4	29	9	0	0.313	1.000	1.000
387	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(2), EIF2B2(2), EIF2B3(2), EIF2B4(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), ELAVL1(4), FLT1(4), FLT4(6), HIF1A(3), KDR(7), NOS3(9), PIK3R1(4), PLCG1(7), PRKCA(1), PTK2(9), PXN(2), SHC1(3)	18408399	69	59	66	17	6	13	1	24	25	0	0.396	1.000	1.000
388	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(10), ACAT1(2), ACAT2(5), ACYP1(1), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), DLD(4), GLO1(2), HAGH(1), HAGHL(4), LDHA(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(1), ME2(3), ME3(1), PC(3), PCK1(6), PDHA1(1), PDHA2(3), PDHB(2), PKLR(3)	20729821	68	53	68	17	6	15	6	21	19	1	0.355	1.000	1.000
389	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(3), AGXT2(1), AOC2(2), AOC3(1), ATP6V0C(2), CBS(3), CHDH(4), CHKA(1), CPT1B(4), CTH(2), DAO(7), DLD(4), DMGDH(1), GAMT(1), GARS(1), GATM(4), GCAT(3), GLDC(3), MAOA(1), MAOB(8), PLCB2(3), PLCG1(7), PLCG2(7), SARDH(3), SHMT1(2), SHMT2(4), TARS(2)	24199821	84	59	83	15	6	26	6	23	23	0	0.0406	1.000	1.000
390	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CD97(5), CRHR1(5), CRHR2(3), ELTD1(8), EMR1(6), EMR2(1), GHRHR(1), GIPR(1), GLP1R(3), GLP2R(3), GPR64(2), LPHN1(5), LPHN2(3), LPHN3(12), SCTR(2), VIPR1(3), VIPR2(2)	15835387	68	54	66	17	4	10	12	28	14	0	0.302	1.000	1.000
391	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(2), BDKRB2(3), CAV1(1), CHRM1(3), CHRNA1(4), FLT1(4), FLT4(6), KDR(7), NOS3(9), PDE2A(1), PDE3A(8), PDE3B(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKG1(6), PRKG2(4), RYR2(42), SYT1(2)	23947197	113	91	110	29	10	21	12	43	26	1	0.233	1.000	1.000
392	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(2), APC(12), ATF2(1), BMP2(2), BMP4(1), BMP5(4), BMP7(3), BMPR1A(1), BMPR2(5), CHRD(2), DVL1(3), FZD1(2), GSK3B(3), MAP3K7(3), MEF2C(1), NKX2-5(1), NPPB(1), RFC1(7), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), WNT1(2)	19050696	65	56	63	16	7	17	5	21	14	1	0.289	1.000	1.000
393	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(2), AP2A1(1), AP2M1(2), ARF1(1), EEA1(5), GRASP(1), GSK3A(1), GSK3B(3), LYN(1), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PLCG1(7), PRKCZ(4), RPS6KB1(2)	13951933	35	28	33	9	3	11	1	9	11	0	0.630	1.000	1.000
394	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), B4GALT3(2), FUT1(4), FUT3(2), FUT5(1), FUT7(2), FUT9(4), GCNT2(1), ST3GAL6(1)	9028344	23	19	23	8	3	1	3	13	3	0	0.706	1.000	1.000
395	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), DHRS1(1), DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(3), NAT6(1), PNPLA3(1), SH3GLB1(2)	13836182	28	25	28	9	1	5	3	11	8	0	0.728	1.000	1.000
396	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CD3G(1), FOS(1), FYN(1), JUN(2), LAT(1), LCK(4), MAP2K4(4), MAP3K1(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKBIA(2), PIK3R1(4), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), RAF1(2), RASA1(10), RELA(4), SHC1(3), SOS1(8), SYT1(2), VAV1(3), ZAP70(3)	25802936	94	70	92	21	7	16	9	33	28	1	0.310	1.000	1.000
397	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6), P4HB(1), SLC23A1(1), SLC23A2(3), SLC2A3(2)	14617073	48	39	46	16	1	9	6	20	12	0	0.449	1.000	1.000
398	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(8), FOS(1), IKBKB(4), IRAK1(5), JUN(2), LY96(1), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP3K7(3), MAPK14(3), MAPK8(1), MYD88(1), NFKB1(3), NFKBIA(2), PPARA(3), RELA(4), TIRAP(2), TLR10(3), TLR2(1), TLR3(5), TLR4(5), TLR6(4), TLR7(4), TLR9(3), TRAF6(2)	21035369	81	59	81	17	1	20	12	28	20	0	0.213	1.000	1.000
399	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(3), AKT1(2), AKT2(3), AKT3(2), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(5), PITX2(1), PLD1(4), PLD2(3), PLD3(4), VN1R1(1)	26503373	84	62	82	15	8	21	5	32	18	0	0.107	1.000	1.000
400	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ARG2(1), ASL(1), ASS1(3), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), DAO(7), EPRS(4), GAMT(1), GATM(4), GLUD1(3), GLUD2(5), LAP3(3), NOS1(14), NOS3(9), OAT(2), P4HA1(2), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), RARS(3), RARS2(1)	21099059	88	68	87	22	6	22	11	27	22	0	0.259	1.000	1.000
401	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(3), AGXT2(1), AOC2(2), AOC3(1), CBS(3), CHDH(4), CHKA(1), CTH(2), DAO(7), DLD(4), DMGDH(1), GAMT(1), GARS(1), GATM(4), GCAT(3), GLDC(3), GNMT(2), HSD3B7(1), MAOA(1), MAOB(8), PHGDH(3), PSAT1(2), RDH11(1), RDH13(1), RDH14(1), SARDH(3), SARS2(2), SDS(2), SHMT1(2), SHMT2(4), TARS(2), TARS2(4)	24639929	80	56	80	17	8	24	5	21	22	0	0.136	1.000	1.000
402	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(1), CP(6), CPOX(1), EPRS(4), FECH(1), GUSB(8), HCCS(2), HMBS(4), HMOX1(1), PPOX(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5)	15196837	51	39	50	13	1	9	1	16	24	0	0.779	1.000	1.000
403	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(3), B4GALT5(1), C1GALT1(1), C1GALT1C1(1), GALNT1(2), GALNT10(1), GALNT11(1), GALNT12(5), GALNT13(4), GALNT14(3), GALNT3(2), GALNT4(4), GALNT5(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL5(4), GCNT3(2), GCNT4(1), OGT(3), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(7)	18318657	54	44	53	13	9	7	8	19	11	0	0.259	1.000	1.000
404	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH4A1(1), ALDH9A1(1), AOC2(2), AOC3(1), ARG1(1), ARG2(1), ASL(1), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), DAO(7), GAMT(1), GATM(4), GLUD1(3), MAOA(1), MAOB(8), NOS1(14), NOS3(9), OAT(2), ODC1(3), P4HA1(2), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(3), SMS(1)	25633051	96	71	95	19	7	21	8	36	24	0	0.0723	1.000	1.000
405	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA1(1), CA14(1), CA4(2), CA5A(1), CA5B(1), CA6(1), CA8(1), CA9(7), CPS1(12), CTH(2), GLS(4), GLS2(1), GLUD1(3), GLUL(1)	10627182	41	36	41	12	3	11	8	11	8	0	0.446	1.000	1.000
406	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(10), ATP4A(7), ATP5A1(4), ATP5B(4), ATP5C1(1), ATP5F1(1), ATP5G2(1), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), COX10(1), COX4I2(1), COX5A(2), COX5B(2), COX6B1(2), CYC1(3), LHPP(1), NDUFA10(1), NDUFA2(1), NDUFA5(2), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB10(1), NDUFB3(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFV2(2), PPA1(1), SDHA(2), SDHB(1), UQCRB(1)	32178416	98	79	97	21	3	32	11	32	20	0	0.0867	1.000	1.000
407	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(8), CREBBP(6), DUSP1(1), EP300(11), IKBKB(4), IL1B(1), MAP2K3(2), MAP2K6(2), MAP3K7(3), MAPK11(1), MAPK14(3), MYD88(1), NFKB1(3), NFKBIA(2), NR3C1(3), RELA(4), TGFBR1(1), TGFBR2(1), TLR2(1), TNF(1)	16745862	59	48	58	15	1	14	7	23	14	0	0.482	1.000	1.000
408	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AGT(1), AKT1(2), CAMK1(1), CAMK1G(2), CREBBP(6), CSNK1A1(2), EDN1(2), ELSPBP1(2), F2(2), GSK3B(3), HAND1(2), HAND2(2), LIF(1), MAPK1(3), MAPK14(3), MAPK8(1), MEF2C(1), MYH2(7), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NKX2-5(1), PIK3R1(4), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RAF1(2), RPS6KB1(2), SYT1(2)	26958680	87	63	85	20	6	24	8	31	18	0	0.161	1.000	1.000
409	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	CASP10(2), CASP3(3), CASP6(2), CASP8(1), CFLAR(2), DAXX(1), DFFB(1), FADD(1), FAF1(2), JUN(2), LMNA(2), LMNB2(2), MAP2K4(4), MAP3K1(3), MAP3K7(3), MAPK8(1), PAK1(3), PAK2(3), PRKDC(6), PTPN13(14), RIPK2(2), SPTAN1(7)	23261521	67	60	67	15	2	14	5	20	26	0	0.340	1.000	1.000
410	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12B(3), ALOX15B(4), ALOX5(3), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP2U1(3), CYP4A11(3), CYP4A22(5), CYP4F2(1), CYP4F3(2), DHRS4(1), EPHX2(1), GGT1(1), GPX7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(3)	22720676	77	64	75	18	10	16	6	23	22	0	0.202	1.000	1.000
411	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), GOSR1(1), GOSR2(2), SNAP25(3), SNAP29(1), STX10(3), STX12(2), STX16(2), STX18(1), STX19(2), STX2(2), STX5(1), STX6(2), STX8(1), TSNARE1(6), USE1(1), VAMP1(3), VAMP3(1), VTI1A(2), YKT6(2)	9590566	39	33	38	11	2	9	6	13	8	1	0.485	1.000	1.000
412	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(8), IFNB1(2), IKBKB(4), IL1B(1), IL1R1(4), IL1RAP(1), IL6(2), IRAK1(5), IRAK3(3), JUN(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAP3K7(3), MAPK14(3), MAPK8(1), MYD88(1), NFKB1(3), NFKBIA(2), RELA(4), TGFB1(1), TGFB2(4), TGFB3(2), TNF(1), TRAF6(2)	16759493	66	54	66	17	2	17	9	23	15	0	0.416	1.000	1.000
413	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(5), AKT1(2), BAX(3), BCL2(1), CSF2RB(2), IGF1R(11), KIT(12), KITLG(2), PIK3R1(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3)	11137755	50	36	48	15	5	10	4	16	15	0	0.598	1.000	1.000
414	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), DCXR(1), GUSB(8), UGDH(2), UGP2(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5), XYLB(1)	14332604	43	32	41	12	0	8	1	13	21	0	0.917	1.000	1.000
415	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(7), GPRC5A(1), GPRC5C(1), GRM1(4), GRM2(2), GRM3(4), GRM4(4), GRM5(5), GRM7(3), GRM8(7)	11662443	44	37	44	13	6	8	4	20	6	0	0.407	1.000	1.000
416	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), AMDHD1(2), AOC2(2), AOC3(1), DDC(2), FTCD(3), HARS(1), HARS2(1), HDC(4), HEMK1(3), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), PRPS1(1), UROC1(3), WBSCR22(2)	22537379	66	50	66	14	6	16	6	22	15	1	0.186	1.000	1.000
417	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(4), DLD(4), DLST(1), FH(3), IDH2(4), IDH3G(2), MDH1(1), OGDH(1), PC(3), PDHA1(1), PDHA2(3), PDHB(2), PDHX(3), PDK1(1), PDK2(1), PDK3(1), PDK4(2), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1)	16140321	47	40	46	13	3	8	7	13	16	0	0.432	1.000	1.000
418	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3G(1), CD4(1), CREBBP(6), CSK(1), GNAS(10), GNB1(2), HLA-DRA(1), HLA-DRB1(1), LCK(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTPRC(8), ZAP70(3)	13162957	51	39	48	13	6	12	4	21	8	0	0.499	1.000	1.000
419	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3G(1), CD4(1), CREBBP(6), CSK(1), GNAS(10), GNB1(2), HLA-DRA(1), HLA-DRB1(1), LCK(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTPRC(8), ZAP70(3)	13162957	51	39	48	13	6	12	4	21	8	0	0.499	1.000	1.000
420	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(2), ACADM(1), ACOX1(2), ACOX2(3), ACOX3(1), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADIPOQ(3), ANGPTL4(2), APOA1(2), APOA2(1), APOA5(1), CD36(3), CPT1A(4), CPT1B(4), CPT2(1), CYP27A1(4), CYP4A11(3), CYP4A22(5), CYP7A1(1), CYP8B1(4), EHHADH(10), FABP1(1), FABP2(1), FABP7(1), GK(1), GK2(1), HMGCS2(2), LPL(1), ME1(1), MMP1(2), NR1H3(4), PCK1(6), PCK2(1), PDPK1(1), PLTP(4), PPARA(3), PPARG(1), RXRA(2), RXRB(8), RXRG(2), SCD(2), SCP2(3), SLC27A1(1), SLC27A4(1), SLC27A5(3), SLC27A6(2), SORBS1(1), UBC(1), UCP1(4)	37014167	125	91	123	29	11	17	21	45	30	1	0.114	1.000	1.000
421	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(2), APOA1(2), APOA2(1), CD36(3), CITED2(2), CPT1B(4), CREBBP(6), DUSP1(1), DUT(1), EHHADH(10), EP300(11), FABP1(1), HSD17B4(1), INS(1), JUN(2), LPL(1), MAPK1(3), ME1(1), MRPL11(1), MYC(2), NCOA1(5), NCOR1(10), NCOR2(14), NFKBIA(2), NR0B2(4), NR1H3(4), NR2F1(2), NRIP1(1), PDGFA(2), PIK3R1(4), PPARA(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PTGS2(3), RELA(4), RXRA(2), SP1(2), STAT5A(2), STAT5B(1), TNF(1)	34112720	131	87	128	28	10	23	17	47	32	2	0.120	1.000	1.000
422	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD5(1), CD7(1), IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL4(1), IL5(1), ITGAX(2), TLR2(1), TLR4(5), TLR7(4), TLR9(3)	10414269	37	32	37	11	0	7	6	19	5	0	0.497	1.000	1.000
423	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3G(1), CXCR3(3), ETV5(2), IFNG(3), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18(2), IL18R1(2), JAK2(4), JUN(2), MAP2K6(2), MAPK14(3), MAPK8(1), STAT4(4), TYK2(1)	10604960	48	41	48	14	3	9	8	17	11	0	0.471	1.000	1.000
424	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT1(2), ACAT2(5), ACMSD(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), AOC2(2), AOC3(1), AOX1(11), CAT(1), CYP19A1(1), CYP1A1(3), CYP2A13(2), CYP2A6(3), CYP2A7(4), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2D6(1), CYP2E1(4), CYP2F1(1), CYP3A4(1), CYP3A5(4), CYP4B1(6), DDC(2), ECHS1(2), EHHADH(10), GCDH(1), HAAO(1), HADHA(3), KMO(1), KYNU(3), MAOA(1), MAOB(8), SDS(2), TPH1(2), WARS(2), WARS2(1)	30965580	114	82	114	27	3	31	11	36	33	0	0.174	1.000	1.000
425	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(9), BCL2(1), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), DFFB(1), FADD(1), GAS2(1), LMNA(2), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), SPTAN1(7), TNFRSF10B(2), TNFRSF25(2), TNFSF10(1)	18994906	64	50	64	16	2	21	6	14	21	0	0.442	1.000	1.000
426	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), BIRC2(4), BIRC3(1), CASP3(3), CASP8(1), CFLAR(2), FADD(1), JUN(2), MAP2K4(4), MAP3K3(1), MAP3K7(3), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), NR2C2(2), RALBP1(1), RIPK1(4), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1)	16319588	42	38	42	11	1	13	5	10	13	0	0.618	1.000	1.000
427	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(3), AKT3(2), ASAH1(2), DAG1(1), DRD2(4), EGFR(6), EPHB2(4), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), PIK3CB(5), PITX2(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), RAF1(2), RGS20(1), SHC1(3), SOS1(8), SOS2(4), SRC(3), STAT3(4), TERF2IP(1)	33391631	128	93	123	27	11	32	9	49	26	1	0.152	1.000	1.000
428	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(2), AOC3(1), CES1(3), DDHD1(2), ESCO1(2), ESCO2(3), LIPA(1), NAT6(1), PLA1A(2), PNPLA3(1), PRDX6(1), SH3GLB1(2)	14222637	22	19	22	9	2	5	3	9	3	0	0.660	1.000	1.000
429	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(15), B3GALT4(1), CDR1(1), DGKI(5), MRPL19(1), RPL11(3), RPL13(2), RPL18(1), RPL18A(3), RPL19(1), RPL21(1), RPL22(1), RPL23(1), RPL27(1), RPL28(1), RPL3(3), RPL35A(1), RPL37(1), RPL4(1), RPL5(1), RPL7A(3), RPL8(1), RPL9(1), RPLP0(1), RPS10(1), RPS13(1), RPS2(1), RPS23(1), RPS27(1), RPS27A(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS6(2), RPS6KA1(1), RPS6KA2(5), RPS6KA6(8), RPS6KB1(2), RPS6KB2(4), RPS7(1), RPS9(1), SLC36A2(3), TSPAN9(1), UBA52(1), UBC(1)	27497119	92	70	90	19	9	21	11	30	21	0	0.0961	1.000	1.000
430	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(8), AP2A1(1), AP2M1(2), BIN1(4), EPN1(3), EPS15(1), NME1(2), NME2(1), PICALM(1), PPP3CA(3), PPP3CB(3), SYNJ1(7), SYNJ2(3), SYT1(2)	12955306	41	36	40	13	5	8	4	13	11	0	0.622	1.000	1.000
431	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ALDH4A1(1), ALDH5A1(1), CAD(4), CPS1(12), EPRS(4), GAD1(5), GAD2(1), GCLC(1), GCLM(1), GFPT1(1), GFPT2(2), GLS(4), GLS2(1), GLUD1(3), GLUD2(5), GLUL(1), GMPS(4), GNPNAT1(1), GPT(1), GPT2(2), GSR(3), GSS(1), NAGK(3), PPAT(4), QARS(1)	22347634	70	47	69	17	2	21	9	18	20	0	0.217	1.000	1.000
432	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(10), ACADL(2), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), LDHA(1), LDHB(1), LDHC(1), MUT(4), PCCA(1), PCCB(1), SDS(2), SUCLA2(2), SUCLG1(1), SUCLG2(1)	18698676	62	44	62	17	1	15	6	19	21	0	0.485	1.000	1.000
433	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(2), CFL1(1), CHN1(1), LIMK1(4), MAP3K1(3), MYLK(3), NCF2(1), PAK1(3), PDGFRA(5), PIK3R1(4), PLD1(4), PPP1R12B(4), RALBP1(1), RPS6KB1(2), TRIO(6), VAV1(3), WASF1(1)	18554186	48	39	47	12	4	11	3	20	10	0	0.450	1.000	1.000
434	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), ARG1(1), ARG2(1), ASL(1), ASS1(3), CPS1(12), GATM(4), MAOA(1), MAOB(8), NAGS(1), ODC1(3), SMS(1), SRM(2)	16706548	50	40	49	13	2	11	5	18	14	0	0.341	1.000	1.000
435	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	AZIN1(3), BTG1(1), CBX3(2), CLDN5(1), CLOCK(1), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(4), ETV6(1), GFRA1(2), GSTM3(1), GSTP1(2), HSPA8(2), IDI1(1), KLF9(3), MYF6(1), NCKAP1(3), NCOA4(2), NR1D2(1), PER1(6), PER2(4), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(3), TOB1(4), TUBB3(1), UGP2(3), VAPA(1), ZFR(2)	20739295	63	53	61	15	5	16	7	21	13	1	0.270	1.000	1.000
436	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(2), ASAH1(2), CAMP(1), CREB1(1), CREB5(2), CREBBP(6), DAG1(1), EGR2(1), EGR3(2), EGR4(1), GNAQ(1), JUN(2), MAP1B(15), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), NTRK1(5), PIK3C2G(7), PIK3CD(5), PIK3R1(4), PTPN11(4), SHC1(3), SRC(3), TERF2IP(1), TH(1)	28039889	89	64	89	22	8	20	7	28	25	1	0.296	1.000	1.000
437	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(10), ACACB(10), ACADM(1), ACAT1(2), ACAT2(5), ACSS1(2), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH7A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), HIBCH(6), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), MUT(4), PCCA(1), PCCB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1)	22375656	80	57	79	22	2	21	9	27	21	0	0.345	1.000	1.000
438	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(5), ACOT11(1), ACYP1(1), DHRS1(1), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(10), ESCO1(2), ESCO2(3), FN3K(1), GCDH(1), HADHA(3), NAT6(1), PNPLA3(1), SH3GLB1(2)	14465877	38	28	38	11	1	8	6	16	7	0	0.456	1.000	1.000
439	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(3), ALG11(1), ALG13(1), ALG14(1), ALG2(1), ALG5(3), ALG6(1), ALG8(1), ALG9(1), B4GALT2(1), B4GALT3(2), DDOST(1), DOLPP1(1), DPM1(1), FUT8(2), GANAB(3), MAN1A1(3), MAN1A2(3), MAN1B1(1), MAN1C1(1), MAN2A1(8), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(3), RFT1(2), RPN1(1), RPN2(2), ST6GAL1(1), STT3B(4)	24422455	69	47	69	15	3	22	6	24	13	1	0.158	1.000	1.000
440	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(5), CCNB1(2), CDC25C(3), GNAI1(4), GNAS(10), GNB1(2), MAPK1(3), MYT1(2), PIN1(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RPS6KA1(1), SRC(3)	11883513	46	39	42	13	7	12	4	16	7	0	0.535	1.000	1.000
441	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP4A(1), INPP4B(6), INPP5A(3), INPPL1(1), ITPKA(1), ITPKB(4), MIOX(1), OCRL(4), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3CB(5), PIK3CG(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCG1(7), PLCG2(7)	24551358	90	64	86	22	5	22	10	26	27	0	0.316	1.000	1.000
442	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(9), CCNA1(3), CCNB1(2), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDKN1B(5), CDKN1C(2), CDKN2B(1), CDKN2C(2), CREB3L1(2), CREB3L3(5), CREB3L4(3), E2F1(3), E2F3(2), E2F4(2), E2F6(2), GBA2(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), MYC(2), MYT1(2), NACA(5), POLE(4), POLE2(4), PRIM1(3), RBL1(4), RPA1(1), RPA2(2), TFDP1(2), TFDP2(3), TNXB(12), WEE1(2)	42348059	122	85	117	24	5	23	12	50	31	1	0.0241	1.000	1.000
443	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(3), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH5A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), HMGCL(2), L2HGDH(2), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(2), SDHB(1), SDS(2)	14579310	57	44	56	18	2	12	7	25	11	0	0.630	1.000	1.000
444	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2A1L(1), GTF2B(3), GTF2E1(3), GTF2F1(1), GTF2H4(3), GTF2I(2), GTF2IRD1(1), STON1(6), TAF1(8), TAF10(1), TAF1L(6), TAF2(5), TAF4(1), TAF4B(4), TAF6(4), TAF6L(1), TAF7L(2), TAF9B(3), TBPL1(2), TBPL2(1)	20973990	60	49	58	15	3	20	8	16	11	2	0.193	1.000	1.000
445	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(9), CCND1(1), CREBBP(6), EP300(11), ERCC3(3), ESR1(6), GRIP1(6), GTF2A1(2), GTF2E1(3), GTF2F1(1), HDAC2(3), HDAC4(7), HDAC5(4), HDAC6(7), MEF2C(1), NCOR2(14), NR0B1(3), NRIP1(1), PELP1(5), POLR2A(7), TBP(1)	27171547	101	76	97	28	9	27	12	30	21	2	0.222	1.000	1.000
446	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), BNIP3L(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), CHUK(8), DFFB(1), FADD(1), FAS(3), GZMB(2), HELLS(5), IKBKB(4), IRF1(1), IRF2(5), IRF3(1), IRF4(2), IRF5(1), IRF6(1), IRF7(1), JUN(2), MAP2K4(4), MAP3K1(3), MAPK10(3), MDM2(1), MYC(2), NFKB1(3), NFKBIA(2), PLEKHG5(2), PRF1(4), RELA(4), RIPK1(4), TNF(1), TNFRSF10B(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(2), TNFSF10(1), TP73(2), TRAF1(1), TRAF3(1)	32781504	117	89	116	29	10	31	12	29	35	0	0.292	1.000	1.000
447	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(9), BAX(3), BCL2(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), CD40(3), CRADD(1), DAXX(1), DFFB(1), FADD(1), FAS(3), IKBKE(1), MCL1(2), NFKB1(3), NFKBIA(2), NGFR(3), NR3C1(3), NTRK1(5), PTPN13(14), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF3(1), TRAF6(2)	24864870	79	66	78	21	5	27	7	21	19	0	0.360	1.000	1.000
448	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA2(1), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH7A1(1), ALDH9A1(1), AOX1(11), BCAT1(2), BCAT2(1), BCKDHA(1), DBT(2), DLD(4), ECHS1(2), EHHADH(10), HADH(1), HADHA(3), HADHB(4), HIBADH(1), HIBCH(6), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), IVD(1), MCCC1(5), MCCC2(2), MUT(4), OXCT1(2), PCCA(1), PCCB(1)	24812374	91	56	89	26	2	28	9	30	22	0	0.373	1.000	1.000
449	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTG1(1), ARHGEF2(5), ARPC5L(1), CDC42(3), CDH1(7), CLDN1(1), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(1), ROCK1(6), ROCK2(3), TLR4(5), TLR5(1), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2), WASL(2), YWHAZ(1)	28657945	85	67	83	20	5	12	9	38	21	0	0.328	1.000	1.000
450	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTG1(1), ARHGEF2(5), ARPC5L(1), CDC42(3), CDH1(7), CLDN1(1), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(1), ROCK1(6), ROCK2(3), TLR4(5), TLR5(1), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2), WASL(2), YWHAZ(1)	28657945	85	67	83	20	5	12	9	38	21	0	0.328	1.000	1.000
451	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(9), ATR(15), BRCA1(9), BRCA2(10), CHEK1(5), CHEK2(5), FANCA(4), FANCC(1), FANCD2(3), FANCE(3), FANCF(3), FANCG(1), HUS1(1), RAD1(1), RAD17(1), RAD50(6), RAD51(2), RAD9A(2), TREX1(1)	24114198	82	59	82	19	5	17	9	32	17	2	0.283	1.000	1.000
452	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), CDC42(3), CREB1(1), CREB5(2), DUSP1(1), EEF2K(1), HSPB1(1), IL1R1(4), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K10(1), MAP3K4(9), MAP3K5(1), MAP3K7(3), MAPK1(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MKNK1(2), MKNK2(3), MYEF2(3), NFKB1(3), NR2C2(2), SRF(1), TRAF6(2)	19528172	65	55	65	19	8	17	9	14	16	1	0.474	1.000	1.000
453	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(5), ADCY3(2), ADCY4(4), ADCY7(1), ADCY8(9), ADCY9(6), ADORA2A(2), ADORA2B(1), ADRA1B(1), ADRA1D(4), ADRB2(3), ADRB3(1), AGTR1(2), ATP2A1(1), ATP2A2(7), ATP2A3(2), ATP2B1(5), ATP2B2(10), ATP2B3(4), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB2(3), BST1(1), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1F(3), CACNA1G(9), CACNA1H(7), CACNA1I(6), CACNA1S(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CCKAR(1), CCKBR(3), CD38(3), CHRM1(3), CHRM2(5), CHRM3(7), CHRM5(2), CHRNA7(1), CYSLTR1(2), CYSLTR2(3), DRD1(1), EDNRA(1), EDNRB(2), EGFR(6), ERBB2(4), ERBB3(8), ERBB4(11), F2R(1), GNA15(1), GNAL(2), GNAQ(1), GNAS(10), GRIN1(5), GRIN2A(6), GRIN2C(5), GRIN2D(2), GRM1(4), GRM5(5), GRPR(1), HRH1(2), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), LHCGR(6), MYLK(3), MYLK2(2), NOS1(14), NOS3(9), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(9), PDGFRA(5), PDGFRB(1), PHKA1(6), PHKA2(3), PHKB(8), PHKG2(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PTGER1(1), PTGER3(7), PTGFR(2), PTK2B(5), RYR1(31), RYR2(42), RYR3(21), SLC25A4(1), SLC25A5(1), SLC25A6(2), SLC8A1(6), SLC8A2(2), SLC8A3(1), SPHK1(7), SPHK2(3), TACR1(2), TACR2(2), TACR3(4), TNNC2(2), TRHR(3), TRPC1(5), VDAC1(2)	158206843	662	262	644	189	66	154	54	251	135	2	0.298	1.000	1.000
454	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(3), BCAR1(3), BCL2(1), BIRC2(4), BIRC3(1), CAPN2(1), CAV1(1), CAV2(1), CCND1(1), CCND2(3), CDC42(3), COL11A1(21), COL11A2(10), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), COMP(5), DIAPH1(5), DOCK1(7), EGF(6), EGFR(6), ERBB2(4), FARP2(4), FIGF(1), FLNA(4), FLNB(10), FLNC(5), FLT1(4), FN1(13), FYN(1), GSK3B(3), HGF(7), IBSP(2), IGF1R(11), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAV(3), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), JUN(2), KDR(7), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MET(2), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PARVA(1), PARVB(1), PDGFA(2), PDGFB(1), PDGFC(3), PDGFD(3), PDGFRA(5), PDGFRB(1), PDPK1(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PRKCA(1), PRKCG(4), PTK2(9), PXN(2), RAC3(1), RAF1(2), RAP1A(2), RAPGEF1(8), RELN(12), ROCK1(6), ROCK2(3), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SRC(3), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TLN1(10), TLN2(9), TNC(7), TNN(8), TNR(11), TNXB(12), VASP(2), VAV1(3), VAV3(8), VCL(3), VEGFA(1), VEGFC(6), VTN(1), VWF(7), ZYX(2)	211404804	769	258	761	209	52	172	79	266	192	8	0.101	1.000	1.000
455	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	245	ACVR1B(2), ACVR1C(1), AKT1(2), AKT2(3), AKT3(2), ARRB1(2), ARRB2(1), ATF2(1), ATF4(4), BDNF(1), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1F(3), CACNA1G(9), CACNA1H(7), CACNA1I(6), CACNA1S(6), CACNA2D1(10), CACNA2D2(6), CACNA2D3(5), CACNA2D4(5), CACNB1(2), CACNB2(1), CACNB4(5), CACNG2(4), CACNG3(2), CACNG4(2), CACNG5(1), CACNG6(1), CACNG7(2), CACNG8(2), CASP3(3), CDC25B(2), CDC42(3), CHUK(8), DAXX(1), DUSP1(1), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(1), DUSP6(2), DUSP7(1), DUSP8(2), DUSP9(1), ECSIT(2), EGF(6), EGFR(6), FAS(3), FGF12(1), FGF14(1), FGF20(3), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGF9(1), FGFR1(2), FGFR2(4), FGFR3(3), FGFR4(6), FLNA(4), FLNB(10), FLNC(5), FOS(1), GADD45G(1), GNA12(1), GNG12(1), IKBKB(4), IL1B(1), IL1R1(4), IL1R2(1), JUN(2), JUND(1), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K6(1), MAP3K7(3), MAP3K8(1), MAP4K1(1), MAP4K2(4), MAP4K3(1), MAP4K4(4), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK7(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MAPT(6), MEF2C(1), MKNK1(2), MKNK2(3), MOS(2), MYC(2), NF1(14), NFATC2(7), NFATC4(5), NFKB1(3), NFKB2(2), NLK(2), NR4A1(3), NRAS(3), NTF3(1), NTRK1(5), NTRK2(6), PAK1(3), PAK2(3), PDGFA(2), PDGFB(1), PDGFRA(5), PDGFRB(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PPM1B(1), PPP3CA(3), PPP3CB(3), PPP5C(4), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PTPN5(4), PTPRR(2), RAC3(1), RAF1(2), RAP1A(2), RAPGEF2(7), RASA1(10), RASA2(2), RASGRF1(6), RASGRF2(5), RASGRP1(5), RASGRP3(1), RASGRP4(3), RPS6KA1(1), RPS6KA2(5), RPS6KA4(2), RPS6KA5(5), RPS6KA6(8), SOS1(8), SOS2(4), SRF(1), STK3(6), STK4(1), STMN1(1), TAOK1(5), TAOK2(4), TAOK3(4), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TRAF6(2), ZAK(3)	168605444	611	238	600	174	63	130	70	205	140	3	0.151	1.000	1.000
456	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	133	ACTG1(1), COL11A1(21), COL11A2(10), COL17A1(5), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), COMP(5), DES(3), DSC1(2), DSC2(4), DSC3(1), DSG1(1), DSG2(2), DSG3(5), DSG4(7), FN1(13), GJA1(1), GJA10(1), GJA4(1), GJA5(3), GJA8(6), GJB2(1), GJB4(2), GJB5(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJD2(2), GJD4(2), IBSP(2), INA(1), ITGA6(3), ITGB4(9), KRT1(7), KRT12(1), KRT13(2), KRT14(1), KRT15(3), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT20(5), KRT23(1), KRT24(3), KRT27(4), KRT28(2), KRT3(1), KRT31(3), KRT32(4), KRT33A(2), KRT33B(2), KRT34(5), KRT35(4), KRT36(2), KRT37(2), KRT38(5), KRT39(2), KRT4(1), KRT40(5), KRT5(4), KRT6A(3), KRT6B(2), KRT6C(2), KRT7(3), KRT71(3), KRT73(2), KRT74(1), KRT75(3), KRT76(2), KRT77(1), KRT78(1), KRT79(5), KRT81(4), KRT83(3), KRT84(2), KRT85(3), KRT86(2), KRT9(3), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), LMNA(2), LMNB2(2), NES(8), RELN(12), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNC(7), TNN(8), TNR(11), TNXB(12), VIM(4), VTN(1), VWF(7)	141699090	571	228	566	166	43	102	61	223	134	8	0.259	1.000	1.000
457	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(2), ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), ADRA1B(1), ADRA2B(1), ADRA2C(1), ADRB2(3), ADRB3(1), AGTR1(2), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CALCR(1), CCKAR(1), CCKBR(3), CGA(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CNR1(3), CNR2(1), CRHR1(5), CRHR2(3), CTSG(1), CYSLTR1(2), CYSLTR2(3), DRD1(1), DRD2(4), DRD3(2), DRD5(1), EDNRA(1), EDNRB(2), F2(2), F2R(1), F2RL3(1), FPR1(1), FSHR(4), GABBR1(7), GABBR2(3), GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7), GABRB1(4), GABRB2(2), GABRB3(3), GABRG1(10), GABRG2(4), GABRG3(3), GABRP(1), GABRQ(8), GABRR1(2), GABRR2(2), GALR2(1), GH1(1), GH2(3), GHR(3), GHRHR(1), GHSR(2), GIPR(1), GLP1R(3), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(1), GLRB(1), GPR156(4), GPR35(2), GPR50(2), GPR63(7), GPR83(4), GRIA1(10), GRIA2(9), GRIA3(6), GRIA4(11), GRID1(5), GRID2(4), GRIK1(5), GRIK2(7), GRIK3(4), GRIK4(4), GRIK5(2), GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRIN3A(6), GRIN3B(3), GRM1(4), GRM2(2), GRM3(4), GRM4(4), GRM5(5), GRM7(3), GRM8(7), GRPR(1), GZMA(3), HCRTR1(1), HCRTR2(2), HRH1(2), HRH3(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), KISS1R(1), LEP(2), LEPR(4), LHB(2), LHCGR(6), LTB4R(1), MC2R(3), MC3R(2), MC4R(2), MC5R(1), MCHR1(1), MCHR2(1), MTNR1A(2), MTNR1B(3), NMBR(1), NMUR1(3), NMUR2(6), NPBWR2(3), NPFFR1(1), NPFFR2(4), NPY1R(3), NPY2R(4), NPY5R(5), NR3C1(3), NTSR2(3), OPRK1(3), OPRL1(2), OPRM1(4), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX7(1), P2RY1(4), P2RY10(3), P2RY13(1), P2RY14(1), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PRL(3), PRLHR(2), PRLR(1), PRSS1(2), PRSS3(1), PTGER1(1), PTGER2(3), PTGER3(7), PTGER4(1), PTGFR(2), PTGIR(2), PTH2R(4), RXFP1(4), RXFP2(1), SCTR(2), SSTR2(1), SSTR4(3), SSTR5(3), TAAR1(1), TAAR2(3), TAAR5(1), TACR1(2), TACR2(2), TACR3(4), TRHR(3), TRPV1(2), TSHR(2), TSPO(1), UTS2R(1), VIPR1(3), VIPR2(2)	125270912	541	225	527	151	49	93	59	243	97	0	0.157	1.000	1.000
458	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	ABI2(2), ACTN1(4), ACTN2(6), ACTN4(2), APC(12), APC2(3), ARAF(5), ARHGEF1(1), ARHGEF12(8), ARHGEF4(4), ARHGEF6(3), ARHGEF7(4), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), ARPC5L(1), BAIAP2(1), BCAR1(3), BDKRB2(3), CDC42(3), CFL1(1), CFL2(2), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CSK(1), CYFIP1(3), CYFIP2(5), DIAPH1(5), DIAPH2(2), DIAPH3(4), DOCK1(7), EGF(6), EGFR(6), EZR(1), F2(2), F2R(1), FGD1(1), FGD3(5), FGF12(1), FGF14(1), FGF20(3), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGF9(1), FGFR1(2), FGFR2(4), FGFR3(3), FGFR4(6), FN1(13), GIT1(2), GNA12(1), GNA13(1), GNG12(1), GSN(2), INS(1), IQGAP1(8), IQGAP2(5), IQGAP3(7), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAD(10), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(3), ITGAX(2), ITGB2(8), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), LIMK1(4), LIMK2(1), MAP2K2(2), MAPK1(3), MOS(2), MSN(3), MYH10(4), MYH14(12), MYH9(3), MYLK(3), MYLK2(2), NCKAP1(3), NCKAP1L(4), NRAS(3), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDGFA(2), PDGFB(1), PDGFRA(5), PDGFRB(1), PFN3(1), PFN4(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PPP1R12B(4), PTK2(9), PXN(2), RAC3(1), RAF1(2), RDX(1), ROCK1(6), ROCK2(3), SCIN(5), SLC9A1(6), SOS1(8), SOS2(4), SSH1(1), SSH2(3), SSH3(2), TIAM1(5), TIAM2(6), VAV1(3), VAV3(8), VCL(3), WASF1(1), WASF2(2), WASL(2)	158834879	539	225	531	153	46	134	51	189	117	2	0.325	1.000	1.000
459	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(3), CD36(3), CD44(4), CD47(2), COL11A1(21), COL11A2(10), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), DAG1(1), FN1(13), FNDC1(7), FNDC3A(3), FNDC5(1), GP1BB(1), GP6(3), HMMR(4), HSPG2(19), IBSP(2), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAV(3), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), RELN(12), SDC2(1), SDC3(1), SDC4(2), SV2A(1), SV2B(3), SV2C(1), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNC(7), TNN(8), TNR(11), TNXB(12), VTN(1), VWF(7)	130554141	504	220	500	143	39	111	50	172	124	8	0.180	1.000	1.000
460	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ADRA1B(1), ADRA1D(4), ADRB2(3), ADRB3(1), ANXA6(1), ARRB1(2), ARRB2(1), ATP1A4(6), ATP1B3(1), ATP2A2(7), ATP2A3(2), ATP2B1(5), ATP2B2(10), ATP2B3(4), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1S(6), CACNB1(2), CAMK1(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), CASQ1(1), CASQ2(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), GJA1(1), GJA4(1), GJA5(3), GJB2(1), GJB4(2), GJB5(1), GJB6(2), GNAI2(1), GNAI3(1), GNAQ(1), GNAZ(2), GNB1(2), GNB2(3), GNB4(1), GNB5(4), GNG12(1), GNG4(1), ITPR1(15), ITPR2(11), ITPR3(11), KCNB1(2), KCNJ3(3), MIB1(4), NME7(1), PLCB3(4), PRKACA(2), PRKACB(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(1), RGS18(4), RGS2(1), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS6(2), RGS7(7), RGS9(1), RYR1(31), RYR2(42), RYR3(21), SLC8A1(6), SLC8A3(1), USP5(4)	107577428	435	213	426	106	46	88	40	178	82	1	0.0403	1.000	1.000
461	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(2), ABLIM1(3), ABLIM2(1), ABLIM3(1), ARHGEF12(8), CDC42(3), CFL1(1), CFL2(2), CXCL12(1), CXCR4(2), DCC(10), DPYSL2(2), DPYSL5(5), EFNA3(1), EFNA4(1), EFNA5(2), EPHA1(5), EPHA2(5), EPHA3(14), EPHA4(13), EPHA5(6), EPHA6(7), EPHA7(7), EPHA8(7), EPHB1(5), EPHB2(4), EPHB3(8), EPHB4(1), EPHB6(3), FES(1), FYN(1), GNAI1(4), GNAI2(1), GNAI3(1), GSK3B(3), L1CAM(7), LIMK1(4), LIMK2(1), LRRC4C(4), MAPK1(3), MET(2), NCK1(1), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NGEF(1), NRAS(3), NRP1(2), NTN1(2), NTN4(2), NTNG1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PLXNA1(4), PLXNA2(7), PLXNA3(4), PLXNB1(4), PLXNB2(5), PLXNB3(8), PLXNC1(8), PPP3CA(3), PPP3CB(3), PTK2(9), RAC3(1), RASA1(10), RGS3(3), RND1(1), ROBO1(13), ROBO2(15), ROBO3(2), ROCK1(6), ROCK2(3), SEMA3A(10), SEMA3C(7), SEMA3D(7), SEMA3E(8), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4C(1), SEMA4D(3), SEMA4F(4), SEMA4G(1), SEMA5A(2), SEMA5B(7), SEMA6A(5), SEMA6B(2), SEMA6C(6), SEMA6D(13), SEMA7A(6), SLIT1(6), SLIT2(9), SLIT3(8), SRGAP1(3), SRGAP3(7), UNC5A(1), UNC5B(2), UNC5C(2), UNC5D(6)	112856095	462	209	454	137	43	98	49	178	92	2	0.516	1.000	1.000
462	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(1), ACTA2(1), ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ARRB1(2), ARRB2(1), ATF2(1), ATF3(3), ATF4(4), ATF5(1), ATP2A2(7), ATP2A3(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CNN1(1), CNN2(1), CORIN(5), CRH(1), CRHR1(5), DGKZ(2), ETS2(1), FOS(1), GABPB2(1), GBA2(1), GJA1(1), GNAQ(1), GNB1(2), GNB2(3), GNB4(1), GNB5(4), GNG12(1), GNG4(1), GSTO1(1), GUCA2B(1), GUCY1A3(4), IGFBP3(2), IGFBP4(1), IL1B(1), IL6(2), ITPR1(15), ITPR2(11), ITPR3(11), JUN(2), MIB1(4), MYLK2(2), NFKB1(3), NOS1(14), NOS3(9), OXTR(1), PDE4B(3), PDE4D(4), PLCB3(4), PLCD1(2), PLCG1(7), PLCG2(7), PRKACA(2), PRKACB(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(1), RGS18(4), RGS2(1), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS6(2), RGS7(7), RGS9(1), RLN1(2), RYR1(31), RYR2(42), RYR3(21), SLC8A1(6), SP1(2), TNXB(12), USP5(4)	99517436	386	191	377	91	32	72	39	153	88	2	0.0761	1.000	1.000
463	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), AMOTL1(3), ASH1L(11), CASK(2), CDC42(3), CGN(3), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CRB3(1), CSNK2A1(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTTN(3), EPB41(1), EPB41L1(3), EPB41L2(2), EPB41L3(11), EXOC3(2), EXOC4(4), F11R(1), GNAI1(4), GNAI2(1), GNAI3(1), HCLS1(2), IGSF5(4), INADL(15), JAM2(3), JAM3(5), LLGL1(1), LLGL2(2), MAGI1(1), MAGI2(6), MAGI3(4), MLLT4(3), MPDZ(8), MPP5(1), MYH1(8), MYH10(4), MYH11(5), MYH13(5), MYH14(12), MYH15(14), MYH2(7), MYH3(6), MYH4(11), MYH6(9), MYH7(13), MYH7B(5), MYH8(5), MYH9(3), NRAS(3), OCLN(3), PARD3(3), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PPP2R3A(3), PPP2R3B(2), PPP2R4(5), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), SPTAN1(7), SRC(3), SYMPK(4), TJAP1(2), TJP1(6), TJP2(2), TJP3(1), VAPA(1), YES1(2), ZAK(3)	108095336	354	183	349	108	21	82	37	134	78	2	0.749	1.000	1.000
464	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(12), APC2(3), AXIN2(6), BTRC(5), CAMK2A(6), CAMK2B(2), CAMK2G(3), CCND1(1), CCND2(3), CER1(1), CHD8(2), CREBBP(6), CSNK1A1(2), CSNK1A1L(3), CSNK1E(3), CSNK2A1(2), CTBP1(1), CUL1(2), CXXC4(1), DAAM1(7), DAAM2(6), DKK1(1), DKK2(4), DVL1(3), DVL2(6), DVL3(1), EP300(11), FBXW11(1), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD4(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GSK3B(3), JUN(2), LEF1(2), LRP5(2), LRP6(2), MAP3K7(3), MAPK10(3), MAPK8(1), MAPK9(3), MMP7(3), MYC(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NKD1(2), NKD2(3), NLK(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PPP3CA(3), PPP3CB(3), PRICKLE1(5), PRICKLE2(6), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PSEN1(2), RAC3(1), ROCK1(6), ROCK2(3), SENP2(3), SFRP2(2), SFRP5(3), SIAH1(4), SMAD2(1), SMAD3(3), SMAD4(5), TBL1X(1), TBL1XR1(4), TBL1Y(2), TCF7(2), TCF7L1(3), TCF7L2(3), VANGL1(3), VANGL2(1), WIF1(6), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	90314269	329	179	322	77	27	71	28	121	80	2	0.0667	1.000	1.000
465	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), ACVR1B(2), ACVR2B(3), AMH(1), AMHR2(2), BMP2(2), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL11(1), CCL13(1), CCL14(1), CCL15(1), CCL16(1), CCL18(1), CCL24(1), CCL25(1), CCL3(1), CCL8(1), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CCR9(1), CD40(3), CD70(2), CLCF1(2), CNTFR(2), CRLF2(1), CSF1(2), CSF1R(1), CSF2RB(2), CSF3R(1), CX3CL1(2), CXCL1(1), CXCL12(1), CXCL13(1), CXCL14(2), CXCL5(1), CXCR3(3), CXCR4(2), EDA(2), EDA2R(2), EDAR(1), EGF(6), EGFR(6), EPOR(1), FAS(3), FLT1(4), FLT3(4), FLT3LG(2), FLT4(6), GDF5(2), GH1(1), GH2(3), GHR(3), HGF(7), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(3), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL13RA1(2), IL17A(1), IL17RA(2), IL17RB(1), IL18(2), IL18R1(2), IL18RAP(6), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(1), IL20RA(3), IL21R(8), IL22(1), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL2RA(1), IL2RB(2), IL2RG(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL7(1), IL7R(1), IL9R(2), INHBA(3), INHBC(1), INHBE(2), KDR(7), KIT(12), KITLG(2), LEP(2), LEPR(4), LIF(1), LIFR(5), LTBR(1), MET(2), MPL(1), NGFR(3), OSMR(1), PDGFB(1), PDGFC(3), PDGFRA(5), PDGFRB(1), PF4(1), PF4V1(1), PPBP(1), PRL(3), PRLR(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFRSF11A(1), TNFRSF11B(4), TNFRSF14(1), TNFRSF18(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(1), TNFRSF8(3), TNFSF10(1), TNFSF11(1), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(13), TSLP(1), VEGFA(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(1)	99705607	376	175	370	121	18	85	38	154	80	1	0.793	1.000	1.000
466	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(10), ACACB(10), AKT1(2), AKT2(3), AKT3(2), ARAF(5), CALML6(2), CBL(4), CBLB(3), CBLC(1), EXOC7(6), FASN(18), FBP1(1), FBP2(2), FLOT1(3), FOXO1(1), G6PC(3), GSK3B(3), GYS1(3), GYS2(5), IKBKB(4), INS(1), INSR(4), IRS1(3), IRS2(2), IRS4(7), LIPE(1), MAP2K2(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MKNK1(2), MKNK2(3), NRAS(3), PCK1(6), PCK2(1), PDE3A(8), PDE3B(2), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PHKA1(6), PHKA2(3), PHKB(8), PHKG2(2), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PKLR(3), PPARGC1A(6), PPP1CA(2), PPP1CC(1), PPP1R3A(6), PPP1R3C(1), PRKAA1(4), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAG2(3), PRKAG3(2), PRKAR1B(1), PRKAR2B(3), PRKCZ(4), PRKX(3), PYGB(2), PYGL(2), PYGM(8), RAF1(2), RAPGEF1(8), RHEB(1), RPS6(2), RPS6KB1(2), RPS6KB2(4), SHC1(3), SHC4(4), SLC2A4(2), SOCS2(1), SOCS3(1), SORBS1(1), SOS1(8), SOS2(4), SREBF1(3), TRIP10(3), TSC1(8), TSC2(12)	91375070	321	166	316	77	26	85	35	94	78	3	0.0311	1.000	1.000
467	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	128	ALCAM(1), CADM1(4), CADM3(2), CD22(5), CD226(1), CD276(1), CD4(1), CD40(3), CD58(1), CD6(3), CD80(4), CD86(2), CD8A(1), CD8B(1), CDH1(7), CDH15(6), CDH2(1), CDH3(1), CDH4(3), CDH5(2), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CNTN1(7), CNTN2(6), CNTNAP2(8), CTLA4(1), ESAM(2), F11R(1), GLG1(6), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOB(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(3), HLA-G(3), ICAM1(1), ICAM3(1), ITGA4(5), ITGA6(3), ITGA8(1), ITGA9(5), ITGAL(5), ITGAM(6), ITGAV(3), ITGB2(8), ITGB7(1), ITGB8(5), JAM2(3), JAM3(5), L1CAM(7), MADCAM1(1), MAG(2), MPZ(1), NCAM1(5), NCAM2(4), NEGR1(2), NEO1(4), NFASC(10), NLGN2(2), NLGN3(2), NRCAM(8), NRXN1(8), NRXN2(4), NRXN3(6), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(8), PTPRM(11), PVR(3), PVRL1(2), PVRL2(2), PVRL3(2), SDC2(1), SDC3(1), SDC4(2), SELE(1), SELP(1), SELPLG(1), SIGLEC1(6), SPN(3), VCAM1(3), VCAN(12)	82911256	303	165	299	89	19	75	35	109	65	0	0.518	1.000	1.000
468	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(3), AKT3(2), CBL(4), CBLB(3), CBLC(1), CCND1(1), CCND2(3), CISH(5), CLCF1(2), CNTFR(2), CREBBP(6), CRLF2(1), CSF2RB(2), CSF3R(1), EP300(11), EPOR(1), GH1(1), GH2(3), GHR(3), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(3), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL13RA1(2), IL13RA2(2), IL20RA(3), IL21R(8), IL22(1), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL2RA(1), IL2RB(2), IL2RG(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL7(1), IL7R(1), IL9R(2), IRF9(2), JAK2(4), JAK3(7), LEP(2), LEPR(4), LIF(1), LIFR(5), MPL(1), MYC(2), OSMR(1), PIAS2(2), PIAS3(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIM1(1), PRL(3), PRLR(1), PTPN11(4), PTPN6(2), SOCS2(1), SOCS3(1), SOCS5(2), SOCS7(1), SOS1(8), SOS2(4), SPRED1(1), SPRY1(3), SPRY2(3), SPRY3(1), SPRY4(1), STAM(2), STAT1(5), STAT3(4), STAT4(4), STAT5A(2), STAT5B(1), STAT6(5), TPO(13), TSLP(1), TYK2(1)	79006156	282	156	275	80	18	66	31	108	58	1	0.419	1.000	1.000
469	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), DRD1(1), DRD2(4), EGF(6), EGFR(6), GJA1(1), GJD2(2), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GRM1(4), GRM5(5), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), HTR2C(3), ITPR1(15), ITPR2(11), ITPR3(11), MAP2K2(2), MAP2K5(1), MAP3K2(5), MAPK1(3), MAPK7(3), NPR1(2), NPR2(3), NRAS(3), PDGFA(2), PDGFB(1), PDGFC(3), PDGFD(3), PDGFRA(5), PDGFRB(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKG1(6), PRKG2(4), PRKX(3), RAF1(2), SOS1(8), SOS2(4), SRC(3), TJP1(6), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2)	74556289	275	153	269	70	24	67	25	101	56	2	0.155	1.000	1.000
470	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ATF4(4), CACNA1C(9), CACNA1D(6), CACNA1F(3), CACNA1S(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CDC42(3), CGA(1), EGFR(6), GNAQ(1), GNAS(10), GNRH1(2), GNRH2(1), ITPR1(15), ITPR2(11), ITPR3(11), JUN(2), LHB(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK7(3), MAPK8(1), MAPK9(3), MMP14(3), MMP2(1), NRAS(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLD1(4), PLD2(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKX(3), PTK2B(5), RAF1(2), SOS1(8), SOS2(4), SRC(3)	73068534	284	153	276	56	27	62	29	92	71	3	0.00191	1.000	1.000
471	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN10(1), CAPN11(8), CAPN2(1), CAPN3(3), CAPN6(4), CAPN7(2), CAPN9(3), CAPNS1(1), CAV1(1), CAV2(1), CDC42(3), CSK(1), DOCK1(7), FYN(1), GIT2(2), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAD(10), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(3), ITGAX(2), ITGB2(8), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAPK10(3), MAPK12(1), MAPK4(5), MAPK6(3), MAPK7(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PDPK1(1), PIK3R2(4), PTK2(9), PXN(2), RAC3(1), RAPGEF1(8), RHO(3), ROCK1(6), ROCK2(3), SDCCAG8(6), SHC1(3), SORBS1(1), SOS1(8), SRC(3), TLN1(10), TNS1(10), VASP(2), VAV3(8), VCL(3), ZYX(2)	78104132	293	153	291	66	24	75	22	97	74	1	0.0516	1.000	1.000
472	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(6), ACTN4(2), DES(3), DMD(19), MYBPC1(1), MYBPC2(3), MYBPC3(2), MYH3(6), MYH6(9), MYH7(13), MYH8(5), MYOM1(13), NEB(17), TCAP(1), TMOD1(1), TNNC2(2), TNNI2(1), TNNT3(1), TPM2(3), TPM3(1), TPM4(1), TTN(133), VIM(4)	79225948	249	152	247	76	14	52	35	102	43	3	0.621	1.000	1.000
473	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), ADRA1B(1), ADRA1D(4), ADRA2C(1), ADRB2(3), ADRB3(1), AGTR1(2), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CCKAR(1), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CCR9(1), CHML(2), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CMKLR1(2), CNR1(3), CNR2(1), CXCR3(3), CXCR4(2), DRD1(1), DRD2(4), DRD3(2), DRD5(1), EDNRA(1), EDNRB(2), F2R(1), F2RL3(1), FPR1(1), FSHR(4), GALR2(1), GHSR(2), GNB2L1(1), GPR17(1), GPR173(2), GPR174(4), GPR3(3), GPR35(2), GPR37(3), GPR37L1(1), GPR4(2), GPR50(2), GPR63(7), GPR83(4), GPR85(2), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(2), HRH1(2), HRH3(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), LHCGR(6), LTB4R(1), MC3R(2), MC4R(2), MC5R(1), MTNR1A(2), MTNR1B(3), NMBR(1), NMUR1(3), NMUR2(6), NPY1R(3), NPY2R(4), NPY5R(5), NTSR2(3), OPN3(1), OPRK1(3), OPRL1(2), OPRM1(4), OR10A5(2), OR11A1(3), OR12D3(3), OR1C1(2), OR1Q1(1), OR2H1(1), OR5V1(3), OR7A5(3), OR8B8(3), OXTR(1), P2RY1(4), P2RY10(3), P2RY12(3), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2), RGR(1), RHO(3), RRH(2), SSTR2(1), SSTR4(3), SUCNR1(2), TRHR(3)	67504399	276	151	267	86	32	52	26	134	32	0	0.328	1.000	1.000
474	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(5), CACNA1A(9), CRH(1), CRHR1(5), GNA12(1), GNA13(1), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GNAZ(2), GRIA1(10), GRIA2(9), GRIA3(6), GRID2(4), GRM1(4), GRM5(5), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), IGF1R(11), ITPR1(15), ITPR2(11), ITPR3(11), LYN(1), MAP2K2(2), MAPK1(3), NOS1(14), NOS3(9), NPR1(2), NPR2(3), NRAS(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PRKCA(1), PRKCG(4), PRKG1(6), PRKG2(4), RAF1(2), RYR1(31)	63976041	295	151	284	58	33	57	30	118	57	0	0.00164	1.000	1.000
475	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	ARAF(5), CASP3(3), CD244(2), CD247(1), FAS(3), FYN(1), GZMB(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-E(3), HLA-G(3), ICAM1(1), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), ITGAL(5), ITGB2(8), KIR2DL3(3), KLRC1(1), KLRC3(2), KLRK1(5), LAT(1), LCK(4), LCP2(5), MAP2K2(2), MAPK1(3), MICA(2), NCR1(2), NCR2(1), NCR3(1), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NRAS(3), PAK1(3), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PPP3CA(3), PPP3CB(3), PRF1(4), PRKCA(1), PRKCG(4), PTK2B(5), PTPN11(4), PTPN6(2), RAC3(1), RAF1(2), SH2D1A(1), SH3BP2(2), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SYK(1), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFSF10(1), VAV1(3), VAV3(8), ZAP70(3)	63043953	247	146	239	51	17	62	22	91	54	1	0.0194	1.000	1.000
476	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(4), ACTN2(6), ACTN4(2), ARHGAP5(3), BCAR1(3), CDC42(3), CDH5(2), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTNND1(3), CXCL12(1), CXCR4(2), CYBA(2), CYBB(2), ESAM(2), EZR(1), F11R(1), GNAI1(4), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(5), ITGAL(5), ITGAM(6), ITGB2(8), ITK(1), JAM2(3), JAM3(5), MAPK11(1), MAPK12(1), MAPK14(3), MLLT4(3), MMP2(1), MMP9(3), MSN(3), NCF1(1), NCF2(1), NCF4(2), NOX1(3), NOX3(5), OCLN(3), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PRKCA(1), PRKCG(4), PTK2(9), PTK2B(5), PTPN11(4), PXN(2), RAP1A(2), RAPGEF3(2), RAPGEF4(2), RHOH(1), ROCK1(6), ROCK2(3), SIPA1(2), THY1(1), TXK(2), VASP(2), VAV1(3), VAV3(8), VCAM1(3), VCL(3)	69442385	244	145	240	46	16	65	28	78	57	0	0.00481	1.000	1.000
477	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(8), ABCA10(6), ABCA12(20), ABCA13(36), ABCA2(8), ABCA3(6), ABCA4(15), ABCA5(4), ABCA6(4), ABCA7(6), ABCA8(2), ABCA9(7), ABCB1(8), ABCB10(2), ABCB11(2), ABCB4(5), ABCB5(12), ABCB6(3), ABCB7(3), ABCB8(2), ABCB9(1), ABCC1(3), ABCC10(6), ABCC11(3), ABCC12(3), ABCC2(4), ABCC3(5), ABCC4(4), ABCC5(5), ABCC6(7), ABCC8(7), ABCC9(6), ABCD1(2), ABCD2(3), ABCD3(1), ABCG1(1), ABCG2(2), ABCG4(6), ABCG5(6), ABCG8(1), CFTR(3), TAP1(2)	68015304	240	143	235	56	16	58	23	92	50	1	0.0363	1.000	1.000
478	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREB1(1), CREB3L1(2), CREB3L2(2), CREB3L3(5), CREB3L4(3), CREBBP(6), DCT(3), DVL1(3), DVL2(6), DVL3(1), EDN1(2), EDNRB(2), EP300(11), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD4(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GSK3B(3), KIT(12), KITLG(2), LEF1(2), MAP2K2(2), MAPK1(3), MITF(1), NRAS(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), POMC(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), RAF1(2), TCF7(2), TCF7L1(3), TCF7L2(3), TYR(5), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	60247229	237	138	228	66	18	62	16	77	63	1	0.428	1.000	1.000
479	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(1), ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ADK(1), ADSL(2), ADSS(2), AK1(1), AK2(1), AK5(1), AK7(5), ALLC(2), AMPD1(5), AMPD2(2), AMPD3(3), ATIC(2), ENPP1(1), ENPP3(4), ENTPD1(3), ENTPD2(1), ENTPD5(1), ENTPD6(3), GART(4), GDA(2), GMPR2(1), GMPS(4), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), GUK1(1), IMPDH1(1), NME1(2), NME2(1), NME6(2), NME7(1), NPR1(2), NPR2(3), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), NUDT5(1), PAICS(2), PAPSS1(2), PAPSS2(1), PDE10A(6), PDE11A(7), PDE1A(2), PDE1C(9), PDE2A(1), PDE3B(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(3), PDE7A(2), PDE7B(1), PDE8A(5), PDE8B(1), PDE9A(2), PFAS(3), PKLR(3), PNPT1(3), POLA1(4), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), PPAT(4), PRIM1(3), PRPS1(1), PRPS1L1(1), PRUNE(2), RFC5(2), RRM1(5), XDH(8), ZNRD1(1)	92449055	275	136	271	81	21	71	17	91	73	2	0.639	1.000	1.000
480	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(11), CBL(4), CBLB(3), CBLC(1), CD247(1), CD3G(1), CD4(1), CD8A(1), CD8B(1), CDC42(3), CHUK(8), CTLA4(1), FOS(1), FYN(1), GRAP2(3), IFNG(3), IKBKB(4), IL10(1), IL4(1), IL5(1), ITK(1), JUN(2), LAT(1), LCK(4), LCP2(5), MALT1(3), MAP3K8(1), NCK1(1), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKB2(2), NFKBIA(2), NRAS(3), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCQ(3), PTPN6(2), PTPRC(8), RASGRP1(5), SOS1(8), SOS2(4), TNF(1), VAV1(3), VAV3(8), ZAP70(3)	56570704	220	136	216	44	16	59	22	74	48	1	0.0157	1.000	1.000
481	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(2), ACTN1(4), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ANGPTL2(1), ARHGEF6(3), ARHGEF7(4), BCAR1(3), CAV1(1), CDC42(3), CSE1L(1), DOCK1(7), EPHB2(4), FYN(1), GRB7(1), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGB3BP(1), MAP2K4(4), MAP2K7(2), MAP3K11(1), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MYLK(3), MYLK2(2), P4HB(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PIK3CB(5), PKLR(3), PLCG1(7), PLCG2(7), PTK2(9), RAF1(2), RALA(2), RHO(3), ROCK1(6), ROCK2(3), SHC1(3), SOS1(8), SOS2(4), SRC(3), TERF2IP(1), TLN1(10), TLN2(9), VASP(2), ZYX(2)	68341472	233	136	231	54	19	52	22	76	63	1	0.0853	1.000	1.000
482	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(2), ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(3), CDH1(7), CREBBP(6), CSNK2A1(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTNND1(3), EGFR(6), EP300(11), ERBB2(4), FARP2(4), FER(2), FGFR1(2), FYN(1), IGF1R(11), INSR(4), IQGAP1(8), LEF1(2), LMO7(7), MAP3K7(3), MAPK1(3), MET(2), MLLT4(3), NLK(2), PARD3(3), PTPN6(2), PTPRB(14), PTPRJ(4), PTPRM(11), PVRL1(2), PVRL2(2), PVRL3(2), RAC3(1), SMAD2(1), SMAD3(3), SMAD4(5), SNAI1(2), SORBS1(1), SRC(3), SSX2IP(3), TCF7(2), TCF7L1(3), TCF7L2(3), TGFBR1(1), TGFBR2(1), TJP1(6), VCL(3), WASF1(1), WASF2(2), WASF3(2), WASL(2), YES1(2)	67241346	220	134	216	60	12	51	35	71	51	0	0.206	1.000	1.000
483	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(5), ADCY8(9), ARAF(5), ATF4(4), CACNA1C(9), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREBBP(6), EP300(11), GNAQ(1), GRIA1(10), GRIA2(9), GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRM1(4), GRM5(5), ITPR1(15), ITPR2(11), ITPR3(11), MAP2K2(2), MAPK1(3), NRAS(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), RAF1(2), RAP1A(2), RAPGEF3(2), RPS6KA1(1), RPS6KA2(5), RPS6KA6(8)	57179661	226	134	221	60	19	55	23	80	48	1	0.200	1.000	1.000
484	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALML6(2), CDIPT(1), CDS1(2), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), FN3K(1), IMPA1(2), IMPA2(2), INPP4A(1), INPP4B(6), INPP5A(3), INPP5B(1), INPP5E(2), INPPL1(1), ITPK1(2), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), OCRL(4), PI4KA(4), PI4KB(2), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3C3(2), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PRKCA(1), PRKCG(4), PTPMT1(1), SYNJ1(7), SYNJ2(3)	70791232	224	131	219	59	16	56	26	62	64	0	0.213	1.000	1.000
485	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(1), ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADK(1), ADSL(2), ADSS(2), AK1(1), AK2(1), AK5(1), ALLC(2), AMPD1(5), AMPD2(2), AMPD3(3), ATIC(2), ATP5A1(4), ATP5B(4), ATP5C1(1), ATP5F1(1), ATP5G2(1), ENPP1(1), ENPP3(4), ENTPD1(3), ENTPD2(1), GART(4), GDA(2), GMPS(4), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), GUK1(1), IMPDH1(1), NME1(2), NME2(1), NPR1(2), NPR2(3), NT5E(1), NT5M(2), PAICS(2), PAPSS1(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(3), PDE6B(8), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(3), PKLR(3), POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), PPAT(4), PRPS1(1), PRPS1L1(1), PRUNE(2), RRM1(5)	72340603	227	131	224	68	17	66	19	79	46	0	0.541	1.000	1.000
486	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), AKAP1(3), AKAP10(1), AKAP11(9), AKAP12(3), AKAP2(4), AKAP3(4), AKAP4(2), AKAP5(1), AKAP6(10), AKAP7(1), AKAP8(3), AKAP9(8), ARHGEF1(1), CHMP1B(3), GNA12(1), GNA13(1), GNA15(1), GNAI2(1), GNAI3(1), GNAL(2), GNAQ(1), GNAZ(2), GNB1(2), GNB2(3), GNB5(4), GNG12(1), GNG4(1), ITPR1(15), KCNJ3(3), NRAS(3), PDE1A(2), PDE1B(2), PDE1C(9), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE7A(2), PDE7B(1), PDE8A(5), PDE8B(1), PLCB3(4), PPP3CA(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), SLC9A1(6), USP5(4)	64601992	213	130	208	58	17	53	19	76	47	1	0.350	1.000	1.000
487	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(2), ABL2(4), AKT1(2), AKT2(3), AKT3(2), ARAF(5), BTC(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), CBL(4), CBLB(3), CBLC(1), CDKN1B(5), EGF(6), EGFR(6), ERBB2(4), ERBB3(8), ERBB4(11), GAB1(3), GSK3B(3), JUN(2), MAP2K2(2), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MYC(2), NCK1(1), NCK2(2), NRAS(3), NRG1(2), NRG2(1), NRG3(3), NRG4(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PRKCA(1), PRKCG(4), PTK2(9), RAF1(2), RPS6KB1(2), RPS6KB2(4), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SRC(3), STAT5A(2), STAT5B(1), TGFA(1)	57472463	228	130	220	47	13	56	22	78	58	1	0.0252	1.000	1.000
488	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(2), ACVR1C(1), ACVR2B(3), ACVRL1(1), AMH(1), AMHR2(2), BMP2(2), BMP4(1), BMP5(4), BMP6(2), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(5), CDKN2B(1), CHRD(2), COMP(5), CREBBP(6), CUL1(2), DCN(2), E2F4(2), EP300(11), FST(2), GDF5(2), ID1(2), IFNG(3), INHBA(3), INHBC(1), INHBE(2), LEFTY2(1), LTBP1(9), MAPK1(3), MYC(2), NODAL(1), PITX2(1), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), RBL1(4), RBL2(11), ROCK1(6), ROCK2(3), RPS6KB1(2), RPS6KB2(4), SMAD2(1), SMAD3(3), SMAD4(5), SMAD6(1), SMAD9(2), SMURF1(4), SMURF2(1), SP1(2), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNF(1), ZFYVE16(6), ZFYVE9(6)	55817335	200	130	197	51	18	44	25	65	45	3	0.145	1.000	1.000
489	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(2), ANAPC1(4), ANAPC11(1), ANAPC2(5), ANAPC4(1), ANAPC5(1), ANAPC7(4), ATM(9), ATR(15), BUB1(2), BUB1B(2), CCNA1(3), CCNA2(4), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDC14A(1), CDC14B(3), CDC16(1), CDC23(1), CDC25B(2), CDC25C(3), CDC7(5), CDK6(1), CDKN1B(5), CDKN1C(2), CDKN2B(1), CDKN2C(2), CHEK1(5), CHEK2(5), CREBBP(6), CUL1(2), E2F1(3), E2F3(2), EP300(11), ESPL1(2), FZR1(6), GADD45G(1), GSK3B(3), HDAC2(3), MAD1L1(2), MAD2L1(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), PKMYT1(1), PLK1(2), PRKDC(6), PTTG1(3), RBL1(4), RBL2(11), SKP2(1), SMAD2(1), SMAD3(3), SMAD4(5), SMC1A(5), SMC1B(3), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2), WEE1(2), YWHAE(1), YWHAZ(1)	75128831	229	128	223	39	14	43	18	90	63	1	0.00267	1.000	1.000
490	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AGL(3), AMY2A(2), AMY2B(1), ASCC3(14), ATP13A2(3), DDX18(3), DDX23(2), DDX4(4), DDX41(1), DDX47(2), DDX50(7), DDX51(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENPP1(1), ENPP3(4), ENTPD7(1), EP400(6), ERCC2(6), ERCC3(3), G6PC(3), GAA(2), GBE1(2), GPI(1), GUSB(8), GYS1(3), GYS2(5), HK1(3), HK2(3), HK3(5), LYZL1(1), MGAM(9), MOV10L1(1), NUDT5(1), PGM1(1), PGM3(2), PYGB(2), PYGL(2), PYGM(8), RAD54B(6), RUVBL2(1), SETX(8), SI(9), SKIV2L2(4), SMARCA2(9), SMARCA5(3), UGDH(2), UGP2(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5)	74961060	203	124	198	76	12	56	16	57	59	3	0.983	1.000	1.000
491	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	69	A2M(5), BDKRB2(3), C1QA(3), C1QC(1), C2(4), C3(10), C3AR1(1), C4A(2), C4B(1), C4BPA(3), C4BPB(1), C5(5), C6(1), C7(1), C8A(4), C8B(4), C9(2), CD46(3), CD55(3), CFB(5), CFH(7), CFI(2), CPB2(2), CR1(9), CR2(9), F10(3), F11(1), F12(1), F13A1(2), F13B(1), F2(2), F2R(1), F3(1), F5(7), F8(5), FGA(12), FGB(3), KLKB1(3), KNG1(3), MASP1(2), MASP2(3), MBL2(1), PLAT(2), PLG(3), PROC(2), SERPINA1(1), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPING1(3), TFPI(2), THBD(3), VWF(7)	59806826	170	122	169	48	7	39	28	51	45	0	0.348	1.000	1.000
492	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(2), AKT2(3), AKT3(2), CASP8(1), CCL3(1), CD40(3), CD80(4), CD86(2), CHUK(8), FADD(1), FOS(1), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IKBKB(4), IKBKE(1), IL12A(6), IL12B(2), IL1B(1), IL6(2), IRAK1(5), IRAK4(4), IRF3(1), IRF5(1), IRF7(1), JUN(2), LBP(3), LY96(1), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K7(3), MAP3K8(1), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), NFKBIA(2), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), RELA(4), RIPK1(4), STAT1(5), TBK1(1), TICAM1(1), TIRAP(2), TLR1(2), TLR2(1), TLR3(5), TLR4(5), TLR5(1), TLR6(4), TLR7(4), TLR8(7), TLR9(3), TNF(1), TRAF3(1), TRAF6(2)	49772757	201	121	199	48	8	54	29	58	52	0	0.157	1.000	1.000
493	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	85	ANPEP(3), CD19(2), CD1A(2), CD1B(4), CD1D(2), CD1E(3), CD22(5), CD33(1), CD36(3), CD37(2), CD38(3), CD3G(1), CD4(1), CD44(4), CD5(1), CD55(3), CD7(1), CD8A(1), CD8B(1), CD9(1), CR1(9), CR2(9), CSF1(2), CSF1R(1), CSF3R(1), EPOR(1), FCER2(1), FLT3(4), FLT3LG(2), GP1BB(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL11RA(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL7(1), IL7R(1), IL9R(2), ITGA1(5), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGAM(6), ITGB3(5), KIT(12), KITLG(2), MME(6), TFRC(2), TNF(1), TPO(13)	47777826	175	119	173	57	8	42	21	64	39	1	0.758	1.000	1.000
494	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	79	ACVR1(2), ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(1), BMPR2(5), BUB1(2), CDIPT(1), CDKL1(2), CDKL2(3), CDS1(2), CLK1(2), CLK2(5), CLK4(5), COL4A3BP(1), CSNK2A1(2), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), IMPA1(2), INPP4A(1), INPP4B(6), INPP5A(3), INPPL1(1), ITPKA(1), ITPKB(4), MAP3K10(1), MOS(2), NEK1(1), NEK3(1), OCRL(4), PAK4(2), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3CB(5), PIK3CG(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCG1(7), PLCG2(7), PLK3(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), PRKG1(6), RAF1(2), RPS6KA1(1), RPS6KA2(5), RPS6KA4(2), RPS6KB1(2), STK11(1), TGFBR1(1)	63482198	209	117	203	58	12	51	24	59	63	0	0.511	1.000	1.000
495	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG1(1), ALG10B(3), ALG11(1), ALG13(1), ALG14(1), ALG2(1), ALG6(1), ALG8(1), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT6(3), B3GNT7(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), B4GALT7(1), C1GALT1(1), C1GALT1C1(1), CHPF(5), CHST11(2), CHST12(2), CHST13(3), CHST14(1), CHST2(3), CHST3(5), CHST6(2), CHST7(2), CHSY1(2), DDOST(1), EXT1(1), EXT2(4), EXTL1(2), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(1), GALNT11(1), GALNT12(5), GALNT13(4), GALNT14(3), GALNT3(2), GALNT4(4), GALNT5(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL5(4), GANAB(3), GCNT3(2), GCNT4(1), HS2ST1(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST5(4), HS6ST2(1), HS6ST3(1), MAN1A1(3), MAN1A2(3), MAN1B1(1), MAN1C1(1), MAN2A1(8), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(3), NDST1(2), NDST2(2), NDST3(4), NDST4(6), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL2(1), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(3), WBSCR17(7), XYLT1(3), XYLT2(1)	63290497	192	116	191	58	23	45	20	68	35	1	0.491	1.000	1.000
496	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(10), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADIPOQ(3), ADIPOR1(2), ADIPOR2(1), AGRP(2), AKT1(2), AKT2(3), AKT3(2), CAMKK1(1), CAMKK2(3), CD36(3), CHUK(8), CPT1A(4), CPT1B(4), CPT2(1), G6PC(3), IKBKB(4), IRS1(3), IRS2(2), IRS4(7), JAK2(4), JAK3(7), LEP(2), LEPR(4), MAPK10(3), MAPK8(1), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIA(2), PCK1(6), PCK2(1), POMC(2), PPARA(3), PPARGC1A(6), PRKAA1(4), PRKAB2(1), PRKAG2(3), PRKAG3(2), PRKCQ(3), PTPN11(4), RELA(4), RXRA(2), RXRB(8), RXRG(2), SLC2A4(2), SOCS3(1), STAT3(4), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TYK2(1)	46582650	169	114	166	46	11	36	22	62	37	1	0.451	1.000	1.000
497	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), CDC40(2), CLK2(5), CLK3(2), CLK4(5), COL2A1(9), CPSF1(8), CPSF2(4), CPSF3(2), CPSF4(2), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(2), DDX20(3), DHX15(3), DHX16(3), DHX38(1), DHX8(6), DHX9(14), DICER1(7), DNAJC8(1), FUS(2), GIPC1(3), NCBP1(4), NCBP2(1), NONO(2), NXF1(3), PABPN1(1), PAPOLA(3), POLR2A(7), PPM1G(3), PRPF4(1), PRPF4B(2), PRPF8(8), PSKH1(4), PTBP1(4), PTBP2(2), RBM17(2), RBM5(4), RNGTT(2), RNMT(1), RNPS1(2), SF3A1(3), SF3A2(1), SF3A3(3), SF3B1(12), SF3B2(2), SF3B4(2), SNRPA(1), SNRPA1(2), SNRPB2(1), SNRPD3(1), SNRPN(4), SNURF(2), SPOP(4), SRPK1(1), SRPK2(1), SRRM1(4), SUPT5H(4), TXNL4A(1), U2AF2(4), XRN2(4)	60138465	205	114	200	45	13	42	13	74	62	1	0.113	1.000	1.000
498	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	78	ABL1(2), ATM(9), BUB1(2), BUB1B(2), CCNA1(3), CCNA2(4), CCNB1(2), CCNB2(1), CCNB3(4), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDAN1(4), CDC14A(1), CDC14B(3), CDC25B(2), CDC25C(3), CDC7(5), CDH1(7), CHEK1(5), CHEK2(5), DTX4(2), E2F1(3), E2F3(2), E2F4(2), E2F6(2), EP300(11), ESPL1(2), GSK3B(3), HDAC2(3), HDAC4(7), HDAC5(4), HDAC6(7), HDAC8(1), MAD1L1(2), MAD2L1(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), MPEG1(4), MPL(1), PLK1(2), PRKDC(6), PTPRA(4), PTTG1(3), RBL1(4), SKP2(1), SMAD4(5), TBC1D8(3), TFDP1(2), TGFB1(1), WEE1(2)	61365235	185	113	179	30	13	30	18	75	48	1	0.00197	1.000	1.000
499	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	BCL2(1), CABIN1(5), CAMK2B(2), CD3G(1), CD69(2), CNR1(3), CREBBP(6), CSNK2A1(2), CTLA4(1), EGR2(1), EGR3(2), EP300(11), FCER1A(1), FOS(1), GATA3(1), GSK3A(1), GSK3B(3), IFNB1(2), IFNG(3), IL10(1), IL1B(1), IL2RA(1), IL4(1), IL6(2), ITK(1), JUNB(1), KPNA5(1), MAP2K7(2), MAPK14(3), MAPK8(1), MAPK9(3), MEF2A(6), MEF2D(3), MYF5(2), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB2(2), NPPB(1), NUP214(9), P2RX7(1), PAK1(3), PIN1(2), PPP3CB(3), PTPRC(8), RELA(4), SLA(1), SP1(2), SP3(3), TGFB1(1), TNF(1), TRPV6(2), VAV1(3), VAV3(8), XPO5(4)	51976331	162	112	159	48	8	39	16	63	36	0	0.518	1.000	1.000
500	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(1), CHUK(8), CREB1(1), DAXX(1), FOS(1), IKBKB(4), JUN(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K6(1), MAP3K7(3), MAP3K8(1), MAP3K9(3), MAP4K1(1), MAP4K2(4), MAP4K3(1), MAP4K4(4), MAP4K5(7), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK4(5), MAPK6(3), MAPK7(3), MAPK8(1), MAPK9(3), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MEF2A(6), MEF2C(1), MEF2D(3), MKNK1(2), MKNK2(3), MYC(2), NFKB1(3), NFKBIA(2), PAK1(3), PAK2(3), RAF1(2), RELA(4), RIPK1(4), RPS6KA1(1), RPS6KA2(5), RPS6KA4(2), RPS6KA5(5), RPS6KB1(2), RPS6KB2(4), SHC1(3), SP1(2), STAT1(5), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1)	55408329	189	112	186	42	14	49	21	63	41	1	0.0493	1.000	1.000
501	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(3), ADAM17(5), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), CASP3(3), CDC42(3), CHUK(8), CSK(1), CXCL1(1), EGFR(6), F11R(1), GIT1(2), IGSF5(4), IKBKB(4), JAM2(3), JAM3(5), JUN(2), LYN(1), MAP2K4(4), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MET(2), NFKB1(3), NFKB2(2), NFKBIA(2), NOD1(1), PAK1(3), PLCG1(7), PLCG2(7), PTPN11(4), PTPRZ1(11), RELA(4), SRC(3), TJP1(6)	40517055	154	108	151	31	6	34	17	56	41	0	0.130	1.000	1.000
502	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(2), AKT2(3), AKT3(2), CDC42(3), CDKN1B(5), CREB1(1), CREB5(2), ERBB4(11), GAB1(3), GSK3A(1), GSK3B(3), IFI27(2), INPPL1(1), IRS1(3), IRS2(2), IRS4(7), MET(2), MYC(2), NOLC1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PARD3(3), PDK1(1), PIK3CD(5), PPP1R13B(4), PREX1(16), PTK2(9), RPS6KA1(1), RPS6KA2(5), RPS6KB1(2), SHC1(3), SLC2A4(2), SOS1(8), SOS2(4), TSC1(8), TSC2(12), YWHAE(1), YWHAZ(1)	40606660	164	108	159	34	16	37	18	56	36	1	0.0157	1.000	1.000
503	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(11), ASH2L(2), CTCFL(2), DOT1L(7), EED(2), EHMT1(4), EHMT2(5), EZH1(5), EZH2(2), FBXO11(4), HCFC1(4), HSF4(2), JMJD6(3), KDM6A(2), MEN1(3), NSD1(8), OGT(3), PAXIP1(2), PPP1CA(2), PPP1CC(1), PRDM2(4), PRDM6(2), PRDM7(1), PRDM9(2), PRMT1(2), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), RBBP5(2), SATB1(6), SETD1A(6), SETD1B(4), SETD2(17), SETD8(3), SETDB1(3), SETMAR(4), SMYD3(2), STK38(1), SUV39H1(1), SUV39H2(3), SUV420H1(6), SUZ12(3), WHSC1(5), WHSC1L1(6)	72117460	166	103	164	52	10	37	19	48	50	2	0.709	1.000	1.000
504	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(3), AKT1(2), AKT2(3), AKT3(2), APAF1(9), ATM(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CAPN1(2), CAPN2(1), CASP10(2), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), CSF2RB(2), DFFB(1), FADD(1), FAS(3), IKBKB(4), IL1B(1), IL1R1(4), IL1RAP(1), IRAK1(5), IRAK3(3), IRAK4(4), MYD88(1), NFKB1(3), NFKB2(2), NFKBIA(2), NTRK1(5), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RELA(4), RIPK1(4), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFRSF1A(1), TNFSF10(1)	46399624	156	99	154	32	11	57	12	33	43	0	0.0447	1.000	1.000
505	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(2), BMP4(1), BMP5(4), BMP6(2), BMP7(3), BTRC(5), CSNK1A1(2), CSNK1A1L(3), CSNK1E(3), CSNK1G1(2), FBXW11(1), GAS1(1), GLI1(5), GLI2(12), GLI3(11), GSK3B(3), HHIP(3), LRP2(18), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(3), PTCH1(1), PTCH2(4), RAB23(2), SHH(1), SMO(1), STK36(2), SUFU(3), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	34801319	125	98	124	35	18	24	11	51	19	2	0.341	1.000	1.000
506	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(4), ADCY6(4), ADCY8(9), CACNA1A(9), CACNA1B(13), GNAS(10), GNAT3(4), GNB1(2), GRM4(4), ITPR3(11), KCNB1(2), PDE1A(2), PLCB2(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(3), SCNN1A(1), SCNN1B(1), SCNN1G(5), TAS1R1(1), TAS1R2(3), TAS1R3(4), TAS2R1(1), TAS2R10(1), TAS2R13(2), TAS2R16(1), TAS2R3(1), TAS2R38(2), TAS2R39(2), TAS2R41(3), TAS2R42(2), TAS2R46(2), TAS2R50(1), TAS2R60(1), TAS2R7(2), TAS2R8(2), TAS2R9(1), TRPM5(3)	33586515	128	98	124	38	17	37	10	44	19	1	0.460	1.000	1.000
507	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(5), CREBBP(6), CTBP1(1), DLL1(2), DTX1(1), DTX2(2), DTX3(5), DTX3L(2), DTX4(2), DVL1(3), DVL2(6), DVL3(1), EP300(11), HDAC2(3), HES1(2), JAG1(2), JAG2(4), LFNG(7), MAML1(2), MAML2(2), MAML3(5), NCOR2(14), NCSTN(4), NOTCH1(7), NOTCH2(10), NOTCH3(12), NOTCH4(10), NUMB(3), NUMBL(1), PSEN1(2), PSEN2(2), PSENEN(1), RBPJ(1), RBPJL(1), SNW1(3)	41505231	145	97	141	42	21	30	13	50	31	0	0.446	1.000	1.000
508	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(2), ALG6(1), CCKBR(3), CCR2(1), CCR3(3), CCR5(2), CELSR1(12), CELSR2(10), CELSR3(11), CHRM2(5), CHRM3(7), CXCR3(3), EDNRA(1), EMR2(1), EMR3(4), F2R(1), FSHR(4), GHRHR(1), GPR116(4), GPR132(3), GPR133(1), GPR135(1), GPR143(1), GPR17(1), GPR55(1), GPR61(2), GPR84(5), GRM1(4), GRPR(1), HRH4(1), LGR6(5), LPHN2(3), LPHN3(12), P2RY13(1), PTGFR(2), SMO(1), SSTR2(1), TAAR5(1), TSHR(2), VN1R1(1)	37702467	126	90	125	35	9	34	10	52	21	0	0.378	1.000	1.000
509	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ANGPTL2(1), ARHGAP1(1), ARHGAP4(2), ARHGEF11(6), CDC42(3), CFL1(1), CFL2(2), GDI2(3), INPPL1(1), ITPR1(15), ITPR2(11), ITPR3(11), LIMK1(4), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDK1(1), PIK3CD(5), PIK3CG(3), PIK3R1(4), PITX2(1), PPP1R13B(4), RACGAP1(5), RHO(3), ROCK1(6), ROCK2(3), SAG(2), WASF1(1), WASL(2)	38367531	137	90	136	34	15	31	11	48	32	0	0.242	1.000	1.000
510	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(1), IMPA1(2), IMPA2(2), INPP4A(1), INPP4B(6), INPP5A(3), INPP5B(1), INPP5E(2), INPPL1(1), IPMK(1), ISYNA1(1), ITPK1(2), ITPKA(1), ITPKB(4), MINPP1(1), MIOX(1), OCRL(4), PI4KA(4), PI4KB(2), PIK3C3(2), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PTPMT1(1), SYNJ1(7), SYNJ2(3)	41070904	124	88	120	38	9	28	18	35	34	0	0.508	1.000	1.000
511	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(2), ATP8A1(8), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CCKAR(1), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CXCR3(3), CXCR4(2), EDNRA(1), EDNRB(2), FPR1(1), FSHR(4), GALR2(1), GHSR(2), GNB2L1(1), GRPR(1), LHCGR(6), MC2R(3), MC3R(2), MC4R(2), MC5R(1), NMBR(1), NPY1R(3), NPY2R(4), NPY5R(5), NTSR2(3), OPRK1(3), OPRL1(2), OPRM1(4), OXTR(1), SSTR2(1), SSTR4(3), TACR1(2), TACR2(2), TACR3(4), TRHR(3), TSHR(2)	28601769	115	87	112	35	13	20	11	54	17	0	0.445	1.000	1.000
512	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(1), APAF1(9), BAG4(1), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), CRADD(1), DAXX(1), DFFB(1), FADD(1), GSN(2), LMNA(2), LMNB2(2), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK8(1), MDM2(1), NFKB1(3), NFKBIA(2), NUMA1(4), PAK2(3), PRKDC(6), PSEN1(2), PSEN2(2), PTK2(9), RASA1(10), RELA(4), RIPK1(4), SPTAN1(7), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1)	38814789	112	83	112	31	2	31	7	32	40	0	0.636	1.000	1.000
513	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(5), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), CDIPT(1), CDS1(2), CHAT(4), CHKA(1), CHPT1(1), CRLS1(1), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(3), ETNK1(1), GNPAT(3), GPAM(5), GPD1L(1), LCAT(3), LYPLA1(1), NAT6(1), PCYT1A(3), PCYT1B(1), PHOSPHO1(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLD1(4), PLD2(3), PNPLA3(1), PPAP2A(3), PPAP2B(1), PPAP2C(2), PTDSS1(2), PTDSS2(2), SH3GLB1(2)	38122195	119	83	117	31	4	29	18	32	36	0	0.234	1.000	1.000
514	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(1), BAX(3), CAD(4), CASP10(2), CASP3(3), CASP8(1), CD7(1), CSNK1A1(2), DAXX(1), DEDD2(3), DIABLO(1), EGFR(6), EPHB2(4), FADD(1), FAF1(2), FAIM2(1), HSPB1(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MET(2), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), NR0B2(4), PTPN13(14), RALBP1(1), RIPK1(4), ROCK1(6), SMPD1(4), TNFRSF6B(1), TPX2(3)	42236640	113	83	110	28	6	26	11	36	34	0	0.455	1.000	1.000
515	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(4), CSK(1), CTLA4(1), DAG1(1), EPHB2(4), FBXW7(3), GRAP2(3), ITK(1), ITPKA(1), ITPKB(4), LAT(1), LCK(4), LCP2(5), MAPK1(3), NCK1(1), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PLCG1(7), PTPRC(8), RAF1(2), RASGRP1(5), RASGRP3(1), RASGRP4(3), SOS1(8), SOS2(4), VAV1(3), ZAP70(3)	32702919	118	83	115	28	7	31	12	50	17	1	0.227	1.000	1.000
516	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), AANAT(2), ACAT1(2), ACAT2(5), ACMSD(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), AOX1(11), CAT(1), CYP1A1(3), CYP1B1(2), DDC(2), ECHS1(2), EHHADH(10), GCDH(1), HAAO(1), HADH(1), HADHA(3), HEMK1(3), HSD17B4(1), KMO(1), KYNU(3), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), NFX1(4), OGDH(1), OGDHL(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), TPH1(2), TPH2(2), WARS(2), WARS2(1), WBSCR22(2)	34042511	115	82	115	30	5	29	16	38	26	1	0.224	1.000	1.000
517	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	EGFR(6), ERBB2(4), ERBB4(11), ETS1(2), ETS2(1), ETV6(1), ETV7(1), MAPK1(3), NOTCH1(7), NOTCH2(10), NOTCH3(12), NOTCH4(10), PIWIL1(4), PIWIL2(2), PIWIL3(5), PIWIL4(6), RAF1(2), SOS1(8), SOS2(4), SPIRE1(6), SPIRE2(1)	28297612	106	81	104	28	7	25	15	40	18	1	0.330	1.000	1.000
518	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C1(2), AKR1C2(1), AKR1C4(1), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), CYP1A1(3), CYP1B1(2), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP2F1(1), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A5(4), DHDH(3), EPHX1(4), GSTA2(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), MGST2(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5)	32183919	96	77	94	24	3	27	3	30	33	0	0.600	1.000	1.000
519	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(12), CCND1(1), CCND2(3), CSNK1E(3), DVL1(3), DVL2(6), DVL3(1), FBXW2(3), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GSK3B(3), JUN(2), LDLR(2), MAPK10(3), MAPK9(3), MYC(2), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(1), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), TCF7(2), WNT1(2), WNT11(1), WNT2(3), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1)	31288352	107	77	105	28	10	21	9	41	25	1	0.337	1.000	1.000
520	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), AK3(1), CAD(4), CDA(3), CTPS2(1), DCTD(1), DHODH(1), DPYD(6), DPYS(1), DUT(1), ENTPD1(3), ENTPD5(1), ENTPD6(3), NME1(2), NME2(1), NME6(2), NME7(1), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), PNPT1(3), POLA1(4), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), PRIM1(3), RFC5(2), RRM1(5), TK1(2), TK2(1), TYMS(1), UCK2(1), UMPS(1), UPB1(1), UPP1(1), UPP2(1), UPRT(1), ZNRD1(1)	46347528	117	73	117	27	10	29	8	34	35	1	0.164	1.000	1.000
521	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(3), AMY2A(2), AMY2B(1), ENPP1(1), ENPP3(4), G6PC(3), GAA(2), GANAB(3), GBE1(2), GPI(1), GUSB(8), GYS1(3), GYS2(5), HK1(3), HK2(3), HK3(5), MGAM(9), PGM1(1), PGM3(2), PYGB(2), PYGL(2), PYGM(8), SI(9), UCHL1(1), UCHL3(2), UGDH(2), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5)	37795366	104	73	101	35	4	27	10	30	32	1	0.827	1.000	1.000
522	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(5), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPS(3), CDIPT(1), CDS1(2), CHAT(4), CHKA(1), CLC(1), CPT1B(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), ETNK1(1), GNPAT(3), LCAT(3), LYPLA1(1), PAFAH1B1(1), PCYT1A(3), PCYT1B(1), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB2(3), PLCG1(7), PLCG2(7), PPAP2A(3), PPAP2B(1), PPAP2C(2)	29209202	102	72	99	28	5	25	11	30	31	0	0.387	1.000	1.000
523	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(4), CDA(3), CTPS2(1), DCTD(1), DHODH(1), DPYD(6), DPYS(1), DUT(1), ENTPD1(3), NME1(2), NME2(1), NT5E(1), NT5M(2), POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), RRM1(5), TK1(2), TK2(1), TYMS(1), UCK2(1), UMPS(1), UNG(3), UPB1(1), UPP1(1)	32876642	98	72	98	24	8	25	11	32	22	0	0.181	1.000	1.000
524	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), ASCC3(14), ATP13A2(3), DDX18(3), DDX23(2), DDX4(4), DDX41(1), DDX47(2), DDX50(7), DDX51(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENTPD7(1), EP400(6), ERCC2(6), ERCC3(3), FPGS(1), MOV10L1(1), NUDT5(1), PTS(2), RAD54B(6), RUVBL2(1), SETX(8), SKIV2L2(4), SMARCA2(9), SMARCA5(3)	35900888	102	71	101	40	8	31	8	28	25	2	0.956	1.000	1.000
525	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AGK(1), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(3), DAK(3), DGAT1(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), GK(1), GK2(1), GLA(1), GLB1(3), GPAM(5), LCT(6), LIPA(1), LIPC(2), LIPF(2), LIPG(2), LPL(1), MGLL(4), PNLIP(1), PNLIPRP1(3), PNPLA3(1), PPAP2A(3), PPAP2B(1), PPAP2C(2)	33927171	107	70	106	33	2	24	17	33	31	0	0.680	1.000	1.000
526	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(8), DAXX(1), EGF(6), EGFR(6), ETS1(2), ETS2(1), FOS(1), HOXA7(2), IKBKB(4), JUN(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK1(3), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), PPP2CA(2), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), RAF1(2), RELA(4), RIPK1(4), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1)	26714068	90	70	88	24	1	19	12	34	24	0	0.644	1.000	1.000
527	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(10), ACACB(10), ACAT1(2), ACAT2(5), ACOT12(5), ACSS1(2), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), DLD(4), GLO1(2), HAGH(1), HAGHL(4), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(1), ME2(3), ME3(1), PC(3), PCK1(6), PCK2(1), PDHA1(1), PDHA2(3), PDHB(2), PKLR(3)	26181407	88	68	88	26	7	22	9	29	20	1	0.476	1.000	1.000
528	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASS(5), ACAT1(2), ACAT2(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(7), ECHS1(2), EHHADH(10), EHMT1(4), EHMT2(5), GCDH(1), HADH(1), HADHA(3), HSD17B4(1), HSD3B7(1), NSD1(8), OGDH(1), OGDHL(3), PLOD1(1), PLOD2(6), PLOD3(1), RDH11(1), RDH13(1), RDH14(1), SETD1A(6), SETDB1(3), SHMT1(2), SHMT2(4), SPCS3(2), SUV39H1(1), SUV39H2(3)	32753892	104	66	103	29	5	25	16	29	29	0	0.401	1.000	1.000
529	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(1), ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(2), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKL(1), PFKM(1), PFKP(2), PGAM4(1), PGK2(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1)	32698784	82	63	81	31	5	15	10	28	24	0	0.849	1.000	1.000
530	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(1), ACADVL(2), ACAT1(2), ACAT2(5), ACOX1(2), ACOX3(1), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CPT1A(4), CPT1B(4), CPT2(1), CYP4A11(3), CYP4A22(5), ECHS1(2), EHHADH(10), GCDH(1), HADH(1), HADHA(3), HADHB(4), HSD17B4(1)	27574408	83	60	83	24	1	20	11	30	21	0	0.455	1.000	1.000
531	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(5), CDT1(1), DIAPH2(2), GMNN(1), MCM10(7), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), NACA(5), POLD1(4), POLD4(1), POLE(4), POLE2(4), PRIM1(3), RFC1(7), RFC2(5), RFC4(1), RFC5(2), RPA1(1), RPA2(2), RPS27A(1), UBA52(1), UBC(1)	28794673	81	58	78	21	6	15	8	32	20	0	0.271	1.000	1.000
532	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT1(1), B3GALT4(1), B3GALT5(2), B3GNT1(1), B3GNT2(1), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT2(1), B4GALT3(2), B4GALT6(2), FUT1(4), FUT3(2), FUT5(1), FUT7(2), FUT9(4), GBGT1(3), GCNT2(1), PIGA(1), PIGB(1), PIGC(2), PIGL(2), PIGM(4), PIGN(6), PIGO(2), PIGQ(3), PIGS(5), PIGV(2), PIGZ(4), ST3GAL1(1), ST3GAL2(1), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(3), ST8SIA5(2)	27880022	76	58	76	22	7	12	9	31	17	0	0.562	1.000	1.000
533	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(3), AKT3(2), ARHGEF11(6), BCL2(1), CDC42(3), GNA13(1), LPA(5), MAP2K4(4), MAP3K1(3), MAP3K5(1), MAPK8(1), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(5), PLD1(4), PLD2(3), PLD3(4), PTK2(9), RDX(1), ROCK1(6), ROCK2(3), SERPINA4(2), SRF(1)	28120719	82	58	81	26	3	22	10	21	26	0	0.745	1.000	1.000
534	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(2), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLG(5), POLG2(2), POLI(1), POLK(2), POLL(1), POLM(1), POLQ(17), PRIM1(3), REV1(6), REV3L(13), RFC5(2)	23426387	73	57	72	23	4	19	6	24	20	0	0.587	1.000	1.000
535	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(9), BMPR1B(2), CCND2(3), CDKN1B(5), DAZL(1), ESR2(1), FSHR(4), GJA4(1), INHA(2), LHCGR(6), MLH1(2), MSH5(3), NCOR1(10), NR5A1(2), NRIP1(1), PGR(5), PRLR(1), PTGER2(3), SMPD1(4), ZP2(2)	19572694	67	57	65	20	8	11	4	25	17	2	0.600	1.000	1.000
536	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(6), EGFR(6), MAPK1(3), PTPRB(14), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SPRY1(3), SPRY2(3), SPRY3(1), SPRY4(1), SRC(3)	14144379	67	57	66	22	3	16	9	23	15	1	0.765	1.000	1.000
537	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKM(1), PFKP(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1)	27366083	68	56	68	28	4	13	8	24	19	0	0.891	1.000	1.000
538	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), CEL(3), DGAT1(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(3), LCT(6), LIPC(2), LIPF(2), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(3), PPAP2A(3), PPAP2B(1), PPAP2C(2)	28001003	83	56	82	22	2	19	14	25	23	0	0.376	1.000	1.000
539	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKM(1), PFKP(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1)	27366083	68	56	68	28	4	13	8	24	19	0	0.891	1.000	1.000
540	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTR2(1), AKT1(2), ANGPTL2(1), CDC42(3), CFL1(1), CFL2(2), FLNA(4), FLNC(5), FSCN1(1), GDI2(3), LIMK1(4), MYH2(7), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), RHO(3), ROCK1(6), ROCK2(3), VASP(2), WASF1(1), WASL(2)	27449486	80	56	80	33	7	16	6	32	19	0	0.969	1.000	1.000
541	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(2), ASAH1(2), B4GALT6(2), DEGS1(1), ENPP7(1), GALC(3), GLA(1), GLB1(3), LCT(6), NEU1(2), NEU2(4), NEU3(2), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(2), SGMS1(4), SGMS2(1), SGPP1(1), SGPP2(2), SMPD1(4), SMPD2(4), SMPD3(1), SMPD4(3), SPHK1(7), SPHK2(3), SPTLC2(1)	20373997	71	55	68	22	7	20	14	15	15	0	0.394	1.000	1.000
542	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(1), ABAT(3), ACAT1(2), ACAT2(5), ACSM1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH5A1(1), ALDH7A1(1), ALDH9A1(1), BDH1(2), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADH(1), HADHA(3), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), HSD3B7(1), L2HGDH(2), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(2), PLA1A(2), PRDX6(1), RDH11(1), RDH13(1), RDH14(1)	23301268	75	55	74	28	4	19	8	28	16	0	0.808	1.000	1.000
543	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(2), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHAL6B(2), LDHB(1), LDHC(1), MDH1(1), PC(3), PCK1(6), PDHA1(1), PDHA2(3), PDHB(2), PDHX(3), PFKL(1), PFKM(1), PFKP(2), PGK2(2), PKLR(3), TPI1(1)	23589659	62	52	61	27	5	13	8	20	15	1	0.925	1.000	1.000
544	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), BLVRA(1), COX10(1), CP(6), CPOX(1), EPRS(4), FECH(1), FTMT(5), GUSB(8), HCCS(2), HMBS(4), HMOX1(1), PPOX(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5)	22757490	67	52	65	19	1	12	3	23	28	0	0.842	1.000	1.000
545	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(1), FBP1(1), FBP2(2), FPGT(3), FUK(2), GMPPA(5), GMPPB(1), HK1(3), HK2(3), HK3(5), HSD3B7(1), LHPP(1), MPI(2), MTMR1(2), MTMR2(1), MTMR6(4), PFKFB1(5), PFKFB2(3), PFKFB3(2), PFKFB4(1), PFKL(1), PFKM(1), PFKP(2), PGM2(3), PHPT1(1), PMM1(1), RDH11(1), RDH13(1), RDH14(1), SORD(1), TPI1(1), TSTA3(3)	21381540	66	51	65	25	5	14	8	22	17	0	0.810	1.000	1.000
546	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), CYP19A1(1), CYP1A1(3), CYP2A13(2), CYP2A6(3), CYP2A7(4), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2D6(1), CYP2E1(4), CYP2F1(1), CYP3A4(1), CYP3A5(4), CYP4B1(6), PON1(1)	16707965	62	49	62	19	2	18	5	19	18	0	0.696	1.000	1.000
547	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(3), CARS(2), CARS2(1), DARS(1), EPRS(4), FARS2(1), FARSA(2), FARSB(1), GARS(1), HARS(1), HARS2(1), IARS(5), IARS2(3), LARS(1), LARS2(2), MARS(6), MTFMT(1), NARS2(2), PARS2(1), QARS(1), RARS(3), RARS2(1), SARS2(2), TARS(2), TARS2(4), VARS(2), VARS2(1), WARS(2), WARS2(1)	30380376	61	49	61	29	2	17	4	14	24	0	0.996	1.000	1.000
548	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), FUCA1(1), FUCA2(1), GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), HGSNAT(4), HPSE(1), HPSE2(2), HYAL1(1), IDS(1), IDUA(1), LCT(6), MAN2B1(2), MAN2B2(3), MAN2C1(5), MANBA(1), NAGLU(3), NEU1(2), NEU2(4), NEU3(2), NEU4(2), SPAM1(4)	20371972	64	49	61	21	6	14	11	19	14	0	0.483	1.000	1.000
549	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(9), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B2(2), EIF2B3(2), EIF2B4(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF4A2(3), EIF4EBP2(1), EIF4G1(7), EIF4G3(6), EIF5(1), EIF5A(2), EIF5B(1), ETF1(1), PABPC3(3), SLC35A4(1)	25166782	54	49	53	21	5	15	10	12	11	1	0.820	1.000	1.000
550	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	21	F10(3), F11(1), F12(1), F13B(1), F2(2), F5(7), F8(5), FGA(12), FGB(3), LPA(5), PLAT(2), PLG(3), SERPINB2(3), SERPINE1(1), VWF(7)	20342162	56	47	55	20	1	19	12	14	10	0	0.643	1.000	1.000
551	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT2(1), FBP2(2), G6PC(3), GAA(2), GALK1(3), GALK2(1), GANAB(3), GLA(1), GLB1(3), HK1(3), HK2(3), HK3(5), LCT(6), MGAM(9), PFKM(1), PFKP(2), PGM1(1), PGM3(2)	18379069	52	47	50	21	4	11	8	18	11	0	0.800	1.000	1.000
552	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT2(1), G6PC(3), GAA(2), GALK1(3), GALK2(1), GLA(1), GLB1(3), HK1(3), HK2(3), HK3(5), HSD3B7(1), LCT(6), MGAM(9), PFKL(1), PFKM(1), PFKP(2), PGM1(1), PGM3(2), RDH11(1), RDH13(1), RDH14(1), UGP2(3)	21793829	55	47	53	27	5	11	8	18	13	0	0.965	1.000	1.000
553	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(3), ABAT(3), ACY3(1), ADSL(2), ADSS(2), AGXT(3), AGXT2(1), ASL(1), ASNS(3), ASRGL1(1), ASS1(3), CAD(4), CRAT(2), DARS(1), DLD(4), GAD1(5), GAD2(1), GPT(1), GPT2(2), NARS2(2), PC(3), PDHA1(1), PDHA2(3), PDHB(2)	21482296	57	47	57	22	5	19	9	17	7	0	0.748	1.000	1.000
554	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(4), ANAPC11(1), ANAPC2(5), ANAPC4(1), ANAPC5(1), ANAPC7(4), BTRC(5), CDC16(1), CDC23(1), CUL1(2), CUL2(3), CUL3(2), FBXW11(1), FBXW7(3), FZR1(6), ITCH(1), SKP2(1), SMURF1(4), SMURF2(1), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2D3(4), UBE2E1(1), UBE2E2(1), WWP1(3), WWP2(1)	22459421	63	47	63	17	5	21	5	12	20	0	0.307	1.000	1.000
555	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(1), ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF1(1), ARHGEF11(6), ARHGEF5(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), BAIAP2(1), CFL1(1), DIAPH1(5), GSN(2), LIMK1(4), MYLK(3), PIP5K1B(1), PPP1R12B(4), ROCK1(6), SRC(3), TLN1(10), VCL(3)	27198006	67	47	67	18	3	15	7	24	18	0	0.507	1.000	1.000
556	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	BAG4(1), CASP3(3), CASP8(1), CRADD(1), DFFB(1), FADD(1), JUN(2), LMNA(2), LMNB2(2), MADD(4), MAP2K4(4), MAP3K1(3), MAP3K7(3), MAPK8(1), PAK1(3), PAK2(3), PRKDC(6), RIPK1(4), SPTAN1(7), TNF(1), TNFRSF1A(1)	21635992	54	47	54	16	1	9	5	14	25	0	0.746	1.000	1.000
557	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(2), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH9A1(1), AOX1(11), BCAT1(2), BCKDHA(1), ECHS1(2), EHHADH(10), HADHA(3), HADHB(4), HIBADH(1), HMGCL(2), IVD(1), MCCC1(5), MCCC2(2), MUT(4), OXCT1(2), PCCA(1), PCCB(1), SDS(2)	20505019	74	47	73	25	0	22	7	25	20	0	0.743	1.000	1.000
558	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(3), ACO1(6), ACO2(3), CLYBL(1), CS(4), DLD(4), DLST(1), FH(3), IDH2(4), IDH3G(2), MDH1(1), OGDH(1), OGDHL(3), PC(3), PCK1(6), PCK2(1), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1)	16260692	53	46	52	18	3	8	11	13	17	1	0.730	1.000	1.000
559	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(8), EGR2(1), EGR3(2), GNAQ(1), MAP3K1(3), MYC(2), NFATC1(2), NFATC2(7), NFKB1(3), NFKBIA(2), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RELA(4), SYT1(2), VIPR2(2)	15696890	60	46	59	19	5	13	5	23	14	0	0.815	1.000	1.000
560	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(3), CMAS(1), CTBS(1), CYB5R3(1), GFPT1(1), GFPT2(2), GNE(2), GNPDA2(2), GNPNAT1(1), HEXA(3), HEXB(1), HK1(3), HK2(3), HK3(5), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), NAGK(3), NANS(1), NPL(1), PGM3(2), PHPT1(1), UAP1(1)	16325440	46	42	46	22	2	9	5	17	13	0	0.951	1.000	1.000
561	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR7(2), CD4(1), CXCR3(3), CXCR4(2), IFNG(3), IFNGR1(3), IFNGR2(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18R1(2), IL4(1), IL4R(1), IL5(1), TGFB1(1), TGFB2(4), TGFB3(2)	11361878	52	42	52	17	3	14	4	25	6	0	0.643	1.000	1.000
562	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), NOS1(14), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), SYT1(2)	13867086	52	42	52	21	5	14	4	20	9	0	0.935	1.000	1.000
563	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(8), CREBBP(6), EP300(11), FADD(1), IKBKB(4), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2)	13052823	48	41	47	17	0	18	4	18	8	0	0.807	1.000	1.000
564	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(3), GTF2B(3), GTF2E1(3), GTF2H4(3), POLR1A(7), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3B(2), POLR3D(2), POLR3E(2), POLR3H(1), TAF6(4), TBP(1)	19943989	52	40	51	14	3	14	6	11	18	0	0.295	1.000	1.000
565	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(3), ARSE(2), ASAH1(2), GALC(3), GLA(1), GLB1(3), LCT(6), NEU1(2), NEU2(4), NEU3(2), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(2), SMPD1(4), SMPD2(4), SPTLC2(1)	13840982	45	39	43	20	3	13	9	11	9	0	0.864	1.000	1.000
566	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(10), ACACB(10), FASN(18), MCAT(2), OXSM(3)	9366085	43	39	43	15	5	9	6	15	8	0	0.639	1.000	1.000
567	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(2), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(4), CYP7A1(1), HADHB(4), HSD3B7(1), LIPA(1), RDH11(1), RDH13(1), RDH14(1), SLC27A5(3), SOAT2(1), SRD5A1(1)	18095693	51	39	51	17	6	13	4	18	10	0	0.632	1.000	1.000
568	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	29	ANXA1(1), ANXA2(1), ANXA3(4), ANXA6(1), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(2), HPGD(3), HSD11B1(2), PLA2G4A(8), PRL(3), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2), PTGIS(2), PTGS1(2), PTGS2(3)	12525829	45	39	43	14	5	7	5	18	10	0	0.646	1.000	1.000
569	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH4A1(1), ALDH5A1(1), CAD(4), CPS1(12), EPRS(4), GAD1(5), GAD2(1), GCLC(1), GCLM(1), GFPT1(1), GLS(4), GLS2(1), GLUD1(3), GLUL(1), GMPS(4), GPT(1), GPT2(2), GSS(1), PPAT(4), QARS(1)	18871065	56	38	55	16	2	16	5	15	18	0	0.514	1.000	1.000
570	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(10), C5(5), C6(1), C7(1), ICAM1(1), IL6(2), ITGA4(5), ITGAL(5), ITGB2(8), SELP(1), SELPLG(1), TNF(1), VCAM1(3)	13872000	44	38	43	19	2	13	3	14	12	0	0.919	1.000	1.000
571	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	AGT(1), EDN1(2), EDNRA(1), EDNRB(2), EGF(6), EGFR(6), FOS(1), JUN(2), MYC(2), NFKB1(3), PLCG1(7), PRKCA(1), RELA(4)	10407520	38	36	36	15	1	11	4	12	10	0	0.939	1.000	1.000
572	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C8B(4), C9(2), MASP1(2)	19299824	39	36	39	13	3	10	5	8	13	0	0.673	1.000	1.000
573	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C9(2), MASP1(2), MASP2(3), MBL2(1)	19684768	39	36	39	15	3	8	6	7	15	0	0.864	1.000	1.000
574	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(1), FBP1(1), FBP2(2), FPGT(3), GMPPA(5), GMPPB(1), HK1(3), HK2(3), HK3(5), MPI(2), PFKFB1(5), PFKFB3(2), PFKFB4(1), PFKM(1), PFKP(2), PMM1(1), SORD(1), TPI1(1)	13690096	41	36	41	16	3	7	8	13	10	0	0.708	1.000	1.000
575	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), HGSNAT(4), HPSE(1), HPSE2(2), HYAL1(1), IDS(1), IDUA(1), LCT(6), NAGLU(3), SPAM1(4)	12075355	39	34	36	14	2	7	9	12	9	0	0.538	1.000	1.000
576	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(3), ADSL(2), ADSS(2), AGXT(3), AGXT2(1), ASL(1), ASNS(3), CAD(4), CRAT(2), DARS(1), GAD1(5), GAD2(1), GPT(1), GPT2(2), PC(3)	14728794	37	33	37	15	3	13	5	11	5	0	0.851	1.000	1.000
577	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(2), DARS(1), EPRS(4), FARS2(1), GARS(1), HARS(1), IARS(5), LARS(1), LARS2(2), MARS(6), QARS(1), RARS(3), TARS(2), WARS(2), WARS2(1)	17773423	36	33	36	13	1	12	2	7	14	0	0.814	1.000	1.000
578	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT2(1), B3GAT3(1), B4GALT7(1), CHPF(5), CHST11(2), CHST12(2), CHST13(3), CHST14(1), CHST3(5), CHST7(2), CHSY1(2), DSE(6), UST(3), XYLT1(3), XYLT2(1)	8256362	39	33	39	14	4	5	4	18	8	0	0.794	1.000	1.000
579	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(1), CASP8(1), FADD(1), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK8(1), NFKB1(3), NSMAF(3), RAF1(2), RELA(4), RIPK1(4), SMPD1(4), TNFRSF1A(1)	11557898	38	32	36	15	3	9	4	11	11	0	0.918	1.000	1.000
580	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(1), IFNG(3), IFNGR1(3), IFNGR2(1), IKBKB(4), JAK2(4), NFKB1(3), NFKBIA(2), RELA(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(2), WT1(6)	9498582	36	32	36	14	1	9	4	15	7	0	0.891	1.000	1.000
581	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(4), EXTL1(2), EXTL3(2), GLCE(2), HS2ST1(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST5(4), HS6ST2(1), HS6ST3(1), NDST1(2), NDST2(2), NDST3(4), NDST4(6)	11948998	39	31	39	18	4	14	1	13	7	0	0.958	1.000	1.000
582	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD3G(1), CD4(1), CXCR3(3), IFNG(3), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), JAK2(4), STAT4(4), TYK2(1)	8440895	35	31	35	13	2	7	4	16	6	0	0.797	1.000	1.000
583	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C9(2)	17475943	33	30	33	11	3	7	4	6	13	0	0.701	1.000	1.000
584	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17)	9491775	33	30	33	12	3	7	4	11	8	0	0.807	1.000	1.000
585	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(1), EGF(6), EGFR(6), MET(2), PDGFRA(5), PRKCA(1), SH3GLB1(2), SH3KBP1(1), SRC(3)	10925246	31	29	30	11	1	7	4	9	10	0	0.841	1.000	1.000
586	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(5), CHAT(4), DDC(2), GAD1(5), GAD2(1), HDC(4), MAOA(1), PAH(2), TH(1), TPH1(2)	8163571	29	28	29	12	4	3	4	11	7	0	0.760	1.000	1.000
587	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(4), GRM1(4), PLCB1(8), PPP1CA(2), PPP1R1B(1), PPP2CA(2), PPP3CA(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3)	9054449	33	28	33	11	4	9	3	12	5	0	0.646	1.000	1.000
588	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ENPP1(1), ENPP3(4), FLAD1(2), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), PHPT1(1), RFK(1), TYR(5)	8571573	33	28	33	12	1	7	5	14	6	0	0.848	1.000	1.000
589	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(6), EP300(11), LPL(1), NCOA1(5), NCOA2(5), PPARG(1), RXRA(2)	10256894	31	28	29	10	0	8	3	13	7	0	0.706	1.000	1.000
590	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(8), DUSP1(1), IKBKAP(5), IKBKB(4), MAP3K1(3), NFKB1(3), NFKBIA(2), RELA(4), TNFAIP3(1), TRAF3(1), TRAF6(2)	10780405	34	27	34	11	0	10	5	12	7	0	0.762	1.000	1.000
591	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL4(1), IL5(1), IL6(2), IL7(1), PDGFA(2), TGFB1(1), TGFB2(4), TGFB3(2), TNF(1)	7741068	34	27	34	11	1	7	3	19	4	0	0.719	1.000	1.000
592	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(1), ITGA4(5), ITGAL(5), ITGAM(6), ITGB2(8), SELE(1), SELP(1)	9136102	31	27	30	13	2	10	2	11	6	0	0.915	1.000	1.000
593	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(4), CSF1(2), IL1B(1), IL6R(3), SPN(3), TGFB1(1), TGFB2(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(3), TNFSF8(1)	7982061	29	27	29	12	2	9	2	10	6	0	0.872	1.000	1.000
594	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(1), ELOVL2(1), ELOVL5(1), FASN(18), HADHA(3), PECR(3), SCD(2)	8718770	31	26	31	16	3	8	3	12	5	0	0.956	1.000	1.000
595	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(4), ATF3(3), DUSP14(1), IFNG(3), IFRD1(2), IL18(2), IL1R1(4), JUND(1), MYOG(1), NR4A3(2), WDR1(3)	6255574	29	26	27	15	1	7	3	6	12	0	0.962	1.000	1.000
596	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), DERA(1), FBP1(1), FBP2(2), G6PD(1), GPI(1), H6PD(5), PFKL(1), PFKM(1), PFKP(2), PGLS(2), PGM1(1), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TALDO1(1), TKT(1), TKTL1(1), TKTL2(3)	13758186	30	25	29	16	2	7	2	12	7	0	0.953	1.000	1.000
597	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CYP2C9(3), DHRS1(1), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(10), ESCO1(2), ESCO2(3), HADHA(3), NAT6(1), PNPLA3(1), SH3GLB1(2)	17286606	38	25	38	11	1	10	5	17	5	0	0.382	1.000	1.000
598	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(2), IMPDH1(1), MTHFD2(2), NME2(1), POLB(2), POLD1(4), POLG(5), RRM1(5), SRM(2)	7414094	26	25	25	10	3	8	1	7	7	0	0.754	1.000	1.000
599	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(5), ADRB2(3), GNAS(10), PLCE1(5), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTGER1(1)	8643494	32	25	29	10	6	9	3	10	4	0	0.626	1.000	1.000
600	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(2), CASP9(1), CDC42(3), CHUK(8), NFKB1(3), PIK3R1(4), RAF1(2), RALA(2), RALBP1(1), RALGDS(1), RELA(4)	9858756	31	25	31	11	2	6	6	7	10	0	0.798	1.000	1.000
601	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(1), GFPT1(1), GNE(2), GNPDA2(2), HEXA(3), HEXB(1), HK1(3), HK2(3), HK3(5), PGM3(2), UAP1(1)	9695540	25	24	25	13	1	5	4	7	8	0	0.866	1.000	1.000
602	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(5), IARS2(3), LARS(1), LARS2(2), PDHA1(1), PDHA2(3), PDHB(2), VARS(2), VARS2(1)	10450689	23	22	23	11	1	7	1	8	6	0	0.954	1.000	1.000
603	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(8), MAP2(6), PPP1CA(2), PPP2CA(2), PRKACB(2), PRKACG(2), PRKAR2B(3)	9417506	25	21	25	10	1	6	0	9	9	0	0.948	1.000	1.000
604	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(10), C5(5), C6(1), C7(1), C8A(4), C9(2)	7140154	23	21	23	10	2	6	2	3	10	0	0.857	1.000	1.000
605	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(1), CASP3(3), CASP8(1), INS(1), INSR(4), ITCH(1), MAGI1(1), MAGI2(6), RERE(3), WWP1(3), WWP2(1)	13367140	27	21	27	13	1	4	6	9	6	1	0.951	1.000	1.000
606	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(1), ITGA4(5), ITGAL(5), ITGB2(8), SELE(1)	6871480	24	21	23	11	1	9	1	9	4	0	0.913	1.000	1.000
607	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(1), GALNT3(2), GALNT4(4), GALNT7(1), GALNT8(2), GALNT9(1), ST3GAL1(1), ST3GAL2(1), WBSCR17(7)	8309821	22	21	22	10	4	2	3	9	4	0	0.872	1.000	1.000
608	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(2), ACAT2(5), ECHS1(2), EHHADH(10), HADHA(3), HADHB(4), SDS(2)	4771563	29	20	29	10	0	7	5	12	5	0	0.628	1.000	1.000
609	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP1(1), FBP2(2), G6PD(1), GPI(1), H6PD(5), PFKM(1), PFKP(2), PGLS(2), PGM1(1), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TALDO1(1), TKT(1)	11379836	24	20	23	15	2	7	0	8	7	0	0.981	1.000	1.000
610	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(8), MAPK14(3), MAPK8(1), NFKB1(3), RELA(4), TNFSF13B(1), TRAF3(1), TRAF5(2), TRAF6(2)	8169182	25	20	25	10	1	6	5	6	7	0	0.875	1.000	1.000
611	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(6), DAXX(1), PAX3(4), PML(2), RARA(1), SIRT1(2), SP100(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1)	9245884	20	19	20	10	0	6	1	8	5	0	0.958	1.000	1.000
612	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP1(1), FBP2(2), GPT(1), GPT2(2), MDH1(1), ME1(1), ME3(1), PGK2(2), PKLR(3), TKT(1), TKTL1(1), TKTL2(3), TPI1(1)	11409570	21	18	20	14	2	4	2	12	1	0	0.980	1.000	1.000
613	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(3), IFNAR1(2), IFNAR2(1), IFNB1(2), MAPK8(1), NFKB1(3), RELA(4), TNFRSF11A(1), TNFSF11(1), TRAF6(2)	6163089	21	17	21	10	2	6	1	7	5	0	0.912	1.000	1.000
614	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP1(1), FBP2(2), GPT(1), GPT2(2), MDH1(1), ME1(1), ME2(3), ME3(1), PKLR(3), TKT(1), TPI1(1)	10237912	18	16	18	12	2	6	1	8	1	0	0.970	1.000	1.000
615	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD3G(1), CD4(1)	1810563	4	3	4	3	0	3	0	1	0	0	0.926	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		842079	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
