rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(1), RAB9A(1)	1187560	12	6	12	1	5	3	2	1	1	0	0.0706	0.238	1.000
2	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(3)	515787	3	3	3	0	1	0	0	2	0	0	0.448	0.386	1.000
3	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(1), FMOD(2), KERA(2), LUM(2)	1001919	7	4	7	1	1	0	1	4	1	0	0.478	0.397	1.000
4	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	3	RANBP1(1), RANGAP1(4)	544748	5	3	5	1	2	2	1	0	0	0	0.365	0.399	1.000
5	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(5), FSHB(1), FSHR(4), XPO1(2)	2056757	12	7	12	1	4	1	2	3	2	0	0.161	0.483	1.000
6	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(10), BMPR1A(4), BMPR2(3)	1735555	17	9	17	3	4	6	2	1	4	0	0.190	0.495	1.000
7	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	6	ADORA2A(1), ADORA3(5), P2RY2(1), P2RY6(1)	1309771	8	6	8	1	4	2	0	0	2	0	0.121	0.508	1.000
8	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(1)	1070904	3	3	3	0	1	1	1	0	0	0	0.341	0.540	1.000
9	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IL12B(1)	830479	5	5	4	2	0	2	0	0	3	0	0.927	0.553	1.000
10	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ARPC1A(2), ARPC2(1), CDC42(1), WASF1(1), WASL(6)	2248368	15	10	13	3	3	4	2	2	4	0	0.382	0.559	1.000
11	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(2)	554983	2	2	2	0	1	1	0	0	0	0	0.477	0.560	1.000
12	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(3)	454101	4	2	4	0	2	1	0	1	0	0	0.236	0.567	1.000
13	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(2), IL6(1), LDLR(1), LPL(4)	1469397	10	5	10	0	3	3	1	1	2	0	0.0233	0.578	1.000
14	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(3), CPS1(5), GLS(1), GOT1(3)	2162834	13	6	12	0	4	2	3	3	0	1	0.0265	0.595	1.000
15	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(4)	895970	5	4	5	1	4	0	0	0	1	0	0.411	0.610	1.000
16	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(1), CHRNB1(4), CHRNG(2), MUSK(7), PIK3R1(2), PTK2(3), SRC(2), TERT(6), YWHAH(1)	4042757	31	18	26	6	7	8	1	4	11	0	0.136	0.631	1.000
17	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1)	315467	1	1	1	0	0	0	0	0	1	0	0.842	0.669	1.000
18	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	GRIA2(1), JUND(1), PPP1R1B(1)	910935	3	3	3	0	0	0	1	1	1	0	0.649	0.688	1.000
19	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	4	AOC2(3), AOC3(3), CES1(2)	1507434	8	5	8	1	4	2	2	0	0	0	0.174	0.691	1.000
20	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	619349	3	2	3	2	0	0	0	1	2	0	0.934	0.701	1.000
21	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), CSF3(2), EPO(2), IL6(1), IL7(1), IL9(1)	1719135	11	5	10	1	1	1	2	4	3	0	0.291	0.703	1.000
22	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	199171	2	1	2	1	2	0	0	0	0	0	0.802	0.711	1.000
23	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ARPC1A(2), ARPC2(1), CDC42(1), PDGFRA(3), PIK3R1(2), WASL(6)	2773823	15	9	13	2	4	4	1	2	4	0	0.220	0.722	1.000
24	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	CREB1(2), HRAS(1), SHC1(2), SRC(2)	1709431	7	6	7	2	2	2	0	0	3	0	0.560	0.727	1.000
25	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB1(7), ABCB11(4), ABCC1(1), ABCC3(5), GSTP1(1)	3252573	18	11	15	2	5	3	3	5	2	0	0.0608	0.740	1.000
26	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(5), UBE2F(1), UBE2G2(1)	1776018	10	5	10	1	4	1	3	1	1	0	0.127	0.743	1.000
27	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	10	ADCY1(5), ADRB2(1), CFTR(5), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SLC9A3R1(1)	3066954	21	11	21	3	8	5	2	4	2	0	0.0408	0.749	1.000
28	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(1), MYC(2), SP1(1), SP3(1)	1729562	5	5	5	0	1	0	1	0	3	0	0.534	0.755	1.000
29	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	5	ARNTL(1), CRY1(1), CRY2(1), CSNK1E(1), PER1(5)	1943148	9	6	8	1	2	1	0	1	5	0	0.357	0.761	1.000
30	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1R(9)	1818711	12	9	10	3	2	3	0	2	5	0	0.431	0.766	1.000
31	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	8	ADAR(5), APOBEC3B(2), APOBEC3G(1)	1820847	8	5	8	1	3	2	2	1	0	0	0.236	0.770	1.000
32	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), TAT(1)	726398	4	2	4	1	0	1	2	1	0	0	0.677	0.777	1.000
33	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	10	BCAT1(2), COASY(2), DPYD(4), ENPP3(3), PANK1(1), PANK3(1), PANK4(2), PPCS(1), UPB1(2)	3421765	18	11	17	2	4	6	2	4	2	0	0.0591	0.779	1.000
34	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), FUT2(3), FUT3(1), ST3GAL4(2)	2012061	11	8	11	2	8	0	0	2	1	0	0.256	0.783	1.000
35	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(2), ACADS(1), ACAT1(2), HADHA(1)	1510553	8	4	8	0	1	4	1	1	1	0	0.0836	0.786	1.000
36	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	6	HSD11B1(1), LPL(4), NR3C1(2), PPARG(1), RXRA(1)	1546719	9	4	9	1	3	1	2	1	2	0	0.177	0.789	1.000
37	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(2), TPI1(3)	1074702	6	3	6	1	3	2	0	1	0	0	0.295	0.792	1.000
38	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2), HLA-DRB1(1)	659834	3	2	3	1	0	0	0	1	2	0	0.905	0.813	1.000
39	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(2), BDH2(1), HMGCS2(1), OXCT1(2), OXCT2(1)	2017978	9	5	9	1	1	5	0	1	2	0	0.148	0.816	1.000
40	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	14	BCAT1(2), BCAT2(2), COASY(2), DPYD(4), ENPP3(3), ILVBL(2), PANK1(1), PANK3(1), PANK4(2), PPCDC(1), PPCS(1), UPB1(2), VNN1(1)	4363460	24	13	23	2	8	7	3	4	2	0	0.00962	0.830	1.000
41	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADH(1), HADHA(1), HADHB(2), HSD17B4(3), MECR(2), PPT1(1), PPT2(3)	2366220	13	6	13	0	3	3	1	2	4	0	0.0205	0.830	1.000
42	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(3)	1273098	4	3	4	2	2	1	1	0	0	0	0.786	0.843	1.000
43	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	9	ACTA1(4), EPHA4(4), EPHB1(2), ITGA1(7), L1CAM(6), LYN(1), RAP1B(3), SELP(3)	4020348	30	17	27	5	12	5	3	4	6	0	0.0485	0.847	1.000
44	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	5	ADCY1(5), GNB1(2), PRKAR1A(1)	1239130	8	4	8	2	3	3	0	1	1	0	0.310	0.847	1.000
45	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	CDK5R1(1), CSNK1D(1), DRD1(5), PLCB1(1), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	3629405	23	11	23	4	10	3	3	5	2	0	0.107	0.849	1.000
46	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3)	3500482	31	14	31	6	7	7	5	5	7	0	0.104	0.852	1.000
47	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATM(11), ATR(10), CHEK2(1), YWHAH(1)	3919061	23	14	23	4	3	2	6	4	8	0	0.470	0.853	1.000
48	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLS(1), OAT(2), PRODH(2)	1579580	9	4	9	1	3	1	2	1	2	0	0.224	0.854	1.000
49	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR161(2), GPR171(2), GPR18(2), GPR34(1), GPR39(4), GPR65(3), GPR75(1)	2740159	16	11	16	4	2	5	1	4	4	0	0.340	0.854	1.000
50	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPT(2), ENPP3(3), FLAD1(5), RFK(1), TYR(4)	2699666	16	9	13	2	5	3	2	1	5	0	0.261	0.856	1.000
51	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(1), HADHA(1)	1347131	3	3	3	1	1	0	1	0	1	0	0.656	0.858	1.000
52	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(3), NR1H4(1), RXRA(1)	1506654	6	4	6	1	2	3	1	0	0	0	0.194	0.860	1.000
53	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	12	F10(4), FGA(6), FGB(4), FGG(2), PROC(1), PROS1(2), SERPINC1(3), TFPI(2)	3300008	24	8	23	5	3	6	9	3	3	0	0.231	0.862	1.000
54	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(1), CD3E(1), CD4(2), CD58(2), CSF3(2), IL6(1)	1737423	11	4	10	1	1	1	1	3	5	0	0.264	0.867	1.000
55	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	3608520	19	12	19	3	12	1	3	1	2	0	0.0811	0.869	1.000
56	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	HLA-DRB1(1)	637989	1	1	1	0	0	0	0	0	1	0	1.000	0.882	1.000
57	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO3(1), FARS2(2), GOT1(3), PAH(1), TAT(1)	2284627	11	7	10	2	3	2	4	2	0	0	0.335	0.883	1.000
58	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(4), CAMP(2), CREB1(2), CREB5(1), SNX13(4), SRC(2), TERF2IP(1)	3154681	19	10	19	2	2	2	4	4	7	0	0.191	0.890	1.000
59	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(2), ARF3(1), CDK4(2), MDM2(2), NXT1(1), PRB1(1)	1973412	9	5	9	1	6	0	3	0	0	0	0.170	0.890	1.000
60	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), OXCT1(2)	933559	4	2	4	0	0	3	0	0	1	0	0.324	0.894	1.000
61	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ARPC1A(2), ARPC2(1), NCK1(3), NCKAP1(4), NTRK1(3), PIR(2), WASF1(1), WASF2(2), WASL(6)	3975004	28	13	26	5	9	6	3	4	6	0	0.180	0.896	1.000
62	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(3), UBE2D1(1), UBE2E1(1), UBE2E3(2), UBE2G2(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(6)	2939320	19	8	17	1	8	4	4	1	2	0	0.0121	0.897	1.000
63	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	6	ATM(11), CDC25B(2), MYT1(12), YWHAH(1)	3283477	26	13	26	5	8	4	4	5	5	0	0.198	0.907	1.000
64	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(3), IDH2(5), OGDH(5), SDHA(6), SUCLA2(1)	2602372	20	10	19	5	3	3	5	6	3	0	0.402	0.910	1.000
65	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(6)	1835786	10	6	9	2	4	0	1	3	2	0	0.436	0.912	1.000
66	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(1), FUT2(3), FUT9(1), GCNT2(1), ST8SIA1(2)	1747926	8	4	8	1	6	1	1	0	0	0	0.134	0.914	1.000
67	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(2), ACADS(1), ACSL1(2), ACSL3(4), ACSL4(3), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1), SCP2(1)	4680162	19	10	19	1	5	4	4	2	4	0	0.0188	0.916	1.000
68	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(2)	1563637	14	6	12	2	6	2	3	0	3	0	0.0911	0.917	1.000
69	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(3), ARHGAP5(6), CASP1(4), CASP10(2), CASP8(2), CASP9(1)	3269260	18	10	17	5	3	3	1	3	7	1	0.635	0.920	1.000
70	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	6	CDC25B(2), CDK7(1)	1721214	3	3	3	1	2	0	0	0	1	0	0.691	0.921	1.000
71	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), ATIC(2), ATP6V0C(1), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(2), SHMT2(4), TYMS(1)	4968172	28	12	26	6	4	4	6	4	9	1	0.172	0.922	1.000
72	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), FH(3), IDH1(1), IDH2(5), MDH2(1), SUCLA2(1)	2458559	15	8	14	2	1	3	5	2	4	0	0.334	0.923	1.000
73	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1)	2228147	8	7	8	2	6	1	1	0	0	0	0.311	0.925	1.000
74	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1)	2228147	8	7	8	2	6	1	1	0	0	0	0.311	0.925	1.000
75	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRP9(1), SRPR(2)	2079787	12	4	12	0	3	4	3	1	1	0	0.0352	0.927	1.000
76	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(4), SPCS1(1)	859342	7	3	7	2	1	1	2	3	0	0	0.638	0.929	1.000
77	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	26	ABAT(2), ACADL(2), ACADM(2), ACADSB(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), CNDP1(2), DPYD(4), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), UPB1(2)	7832383	44	23	44	4	16	8	8	6	5	1	0.000529	0.930	1.000
78	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV2(3)	1686987	10	6	9	3	3	5	0	2	0	0	0.499	0.931	1.000
79	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(3), CPOX(3), HMBS(1), PPOX(2)	2123550	9	7	9	2	3	2	1	1	2	0	0.547	0.931	1.000
80	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3)	4908489	46	22	44	8	11	7	9	7	12	0	0.0419	0.933	1.000
81	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), ATIC(2), DHFR(1), FTCD(2), GART(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(2), SHMT2(4), TYMS(1)	5099221	29	12	27	6	5	4	5	5	9	1	0.140	0.936	1.000
82	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	CD3E(1), HLA-A(7), ICAM1(2), ITGAL(3), ITGB2(1)	2111242	14	6	13	4	4	0	2	3	5	0	0.556	0.940	1.000
83	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(2), ERBB3(6), NRG1(3), UBE2D1(1)	2852820	16	7	16	2	1	4	5	3	3	0	0.195	0.941	1.000
84	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(4), FBXW7(6), RB1(3), TFDP1(1)	2336974	16	9	16	6	2	4	3	3	4	0	0.749	0.943	1.000
85	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF3(2), EPO(2), FLT3(4), IL6(1), IL9(1), TGFB1(1), TGFB2(2)	2336734	14	8	12	3	2	2	4	2	4	0	0.518	0.944	1.000
86	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	6	AGT(1), AGTR2(1), BDKRB2(1), KNG1(2), NOS3(9)	1869733	14	6	14	3	6	0	7	0	1	0	0.327	0.945	1.000
87	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(6), HDC(1), TH(1), TPH1(2)	1705181	11	5	11	5	3	0	3	1	3	1	0.702	0.946	1.000
88	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(6), MEF2A(2), MEF2C(2), MEF2D(2), YWHAH(1)	2235400	16	7	16	2	3	3	7	1	2	0	0.126	0.948	1.000
89	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1), SQLE(2)	907943	6	4	5	3	2	2	1	0	1	0	0.727	0.949	1.000
90	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(3), FUT3(1), FUT5(1), FUT6(2)	1434162	8	5	8	2	5	2	0	0	1	0	0.284	0.950	1.000
91	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(4), LPO(6), MPO(2), TPO(7)	2349521	23	12	23	5	11	1	6	2	3	0	0.140	0.950	1.000
92	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), CD80(1), HLA-DRB1(1)	1100222	4	2	4	1	0	0	1	1	2	0	0.845	0.950	1.000
93	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2), CFLAR(3)	1072663	5	3	5	3	1	0	1	1	2	0	0.841	0.950	1.000
94	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), AKT1(3), ANXA1(3), GNB1(2), NOS3(9), NR3C1(2), PIK3R1(2), RELA(3), SYT1(1)	3830017	26	13	25	6	6	3	8	4	5	0	0.387	0.951	1.000
95	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), KEAP1(2), MAFF(2), MAPK8(2), NFE2L2(1)	2522256	9	5	9	1	2	0	1	3	3	0	0.315	0.951	1.000
96	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	9	CAPN1(1), CAPNS1(3), CAPNS2(2), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(2), MAPT(3), PPP2CA(1)	2068361	15	9	15	5	6	5	0	2	2	0	0.398	0.954	1.000
97	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), TPO(7), TYR(4)	2706020	27	13	26	8	12	2	7	2	4	0	0.356	0.954	1.000
98	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(7), PRKACB(1), PRKACG(3), PRKAR2B(1)	2811189	12	7	12	4	2	3	2	2	3	0	0.702	0.954	1.000
99	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL1(1), FOSL2(3), IFNAR1(2), IFNAR2(1), MAPK8(2), RELA(3), TNFRSF11A(5), TRAF6(1)	3108588	18	9	17	5	1	3	3	5	6	0	0.638	0.955	1.000
100	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	10	ARRB1(1), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	2105512	12	4	12	2	7	3	1	1	0	0	0.121	0.956	1.000
101	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3E(1), CD4(2)	890226	3	1	3	1	0	0	0	1	2	0	0.839	0.957	1.000
102	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(3), TAT(1), TYR(4)	1296960	9	4	9	3	2	1	4	2	0	0	0.695	0.958	1.000
103	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), JUNB(1), MAF(2), MAP2K3(1), NFATC1(4), NFATC2(10), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	3489258	30	16	26	6	14	6	2	2	6	0	0.0228	0.958	1.000
104	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(3), GPI(3), HK1(3), PFKL(2), PGAM1(1), PGK1(3), PKLR(2), TPI1(3)	2596957	22	9	22	6	10	8	1	2	1	0	0.0956	0.958	1.000
105	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	7	CDC25B(2), CSK(1), PTPRA(1), SRC(2)	2022956	6	6	6	2	3	2	1	0	0	0	0.490	0.958	1.000
106	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	5	CDK5R1(1), DAB1(2), LRP8(3), RELN(14), VLDLR(3)	3377683	23	15	19	8	7	4	3	2	6	1	0.711	0.958	1.000
107	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3)	1552564	13	2	13	4	5	3	1	2	2	0	0.424	0.960	1.000
108	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), ADRB2(1), PLCE1(6), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RAP2B(2)	3582318	23	10	23	4	9	2	3	6	3	0	0.133	0.961	1.000
109	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(6), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), WBSCR17(2)	3980509	24	12	23	7	11	3	6	2	2	0	0.381	0.962	1.000
110	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	15	HLA-DRB1(1), IFNGR1(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL2RA(1), IL4R(3)	3149639	12	10	12	4	2	1	2	2	5	0	0.799	0.964	1.000
111	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), ATP6V0C(1), CAT(1), EPX(4), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), SHMT1(2), SHMT2(4), TPO(7)	3314319	33	14	32	7	11	8	8	1	5	0	0.0670	0.965	1.000
112	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	5	BAAT(1), CSAD(1), GAD1(6), GAD2(5), GGT1(1)	1504258	14	7	14	7	4	3	4	1	1	1	0.761	0.966	1.000
113	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(2), FDPS(1), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(2), NQO2(2), SQLE(2), VKORC1(3)	3149254	27	13	25	6	8	7	7	1	4	0	0.122	0.966	1.000
114	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(1), CD4(2), HLA-DRB1(1), LCK(1), PTPRC(3), ZAP70(6)	2206166	14	5	14	2	4	3	1	2	4	0	0.147	0.969	1.000
115	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CD4(2), HLA-DRB1(1), IL1B(1), IL6(1)	1275298	5	2	5	1	0	0	1	1	3	0	0.715	0.970	1.000
116	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2), PNPO(1), PSAT1(2)	1349692	5	4	5	3	1	1	3	0	0	0	0.831	0.970	1.000
117	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(3), HK2(3), HK3(4), PGM1(1), TGDS(1)	2852929	13	7	13	4	8	1	2	0	2	0	0.322	0.970	1.000
118	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	EGFR(2), ELK1(2), GNB1(2), HRAS(1), IGF1R(6), KLK2(1), MKNK2(3), MYC(2), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(4), SHC1(2), SRC(2), STAT3(2)	7960687	36	22	34	8	9	9	3	3	12	0	0.137	0.971	1.000
119	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	6	THBS1(7)	1710622	7	7	4	3	5	2	0	0	0	0	0.466	0.972	1.000
120	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA4(3), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(7), LDLR(1), LPL(4), LRP1(21), SCARB1(1), SOAT1(1)	7616519	50	27	50	9	20	10	5	3	11	1	0.00956	0.972	1.000
121	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	8	CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD3B1(2)	2064192	11	3	11	4	1	5	2	2	1	0	0.504	0.976	1.000
122	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	9	ATM(11), CDC25B(2), CDK4(2), MYT1(12), RB1(3), YWHAH(1)	4123552	31	13	31	5	9	4	7	6	5	0	0.134	0.977	1.000
123	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	594511	3	1	3	1	0	1	2	0	0	0	0.756	0.979	1.000
124	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	14	CD44(4), CSF1(2), IL1B(1), IL6R(1), SELL(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(2), TNFSF8(3)	3095681	20	8	19	9	6	1	3	4	6	0	0.790	0.979	1.000
125	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	AKR1A1(1), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), SIRT1(1), SIRT2(1)	3134879	9	5	9	0	4	1	1	2	1	0	0.0505	0.979	1.000
126	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), SQLE(2)	1204816	6	4	5	3	2	2	1	0	1	0	0.730	0.980	1.000
127	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), HSD3B7(3), PON1(1), PON2(1), RDH11(2)	2505610	13	5	13	2	3	2	3	4	1	0	0.207	0.980	1.000
128	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(5), GNB1(2), PPP2CA(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	3699849	22	7	22	4	8	6	1	3	4	0	0.0700	0.980	1.000
129	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), MIOX(1), UGDH(2)	2391158	9	7	9	3	5	1	1	2	0	0	0.480	0.981	1.000
130	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(3), RDH11(2)	1349588	6	2	6	0	1	0	2	2	1	0	0.192	0.981	1.000
131	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(1), GHR(1), HRAS(1), IGF1R(6), PIK3R1(2), SHC1(2)	3097657	16	9	15	4	6	2	2	2	4	0	0.347	0.981	1.000
132	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	7	CPN2(2), CYP11A1(2), CYP17A1(1), HSD11B1(1), HSD3B1(2)	1634850	8	4	8	4	1	2	3	2	0	0	0.714	0.982	1.000
133	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	23	ABAT(2), ACADM(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), CNDP1(2), DPYD(4), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), UPB1(2)	7058986	37	20	37	4	14	5	8	5	4	1	0.00353	0.982	1.000
134	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	5	TGDS(1), UGDH(2), UXS1(2)	1087579	5	4	5	3	0	1	1	2	1	0	0.924	0.982	1.000
135	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(2), UXS1(2)	1087579	5	4	5	3	0	1	1	2	1	0	0.924	0.982	1.000
136	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(1), COQ7(1)	1160684	2	2	2	2	0	1	0	0	1	0	0.953	0.982	1.000
137	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACPT(2), ENPP3(3), FLAD1(5), MTMR2(1), MTMR6(2), PHPT1(1), RFK(1), TYR(4)	4191351	20	10	17	5	7	4	3	1	5	0	0.526	0.982	1.000
138	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(1), RB1(3), SP1(1), SP3(1)	1851811	6	2	6	0	1	0	3	1	1	0	0.354	0.982	1.000
139	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	20	ACTA1(4), ADCY1(5), GNAI1(1), GNB1(2), HRAS(1), MYT1(12), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RPS6KA1(2), SRC(2)	4892747	38	14	37	8	14	10	4	6	4	0	0.0400	0.983	1.000
140	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3), MASP1(2)	5814449	48	22	46	9	11	7	9	8	13	0	0.0531	0.984	1.000
141	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(7), ATM(11), BRCA1(6), CHEK2(1), MAPK8(2), MDM2(2), MRE11A(4), NFKBIA(2), RAD50(1), RELA(3), TP73(1)	7574891	40	23	35	4	7	4	9	5	15	0	0.0843	0.986	1.000
142	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), FBP2(1), GOT1(3), GPT(2), GPT2(3), MDH2(1), ME1(2), ME2(4), ME3(2), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TPI1(3)	5038960	32	13	32	3	6	10	10	3	3	0	0.00276	0.987	1.000
143	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(1), FDFT1(2), FDPS(1), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NSDHL(2), SQLE(2)	3727666	23	12	22	7	7	6	5	0	5	0	0.407	0.987	1.000
144	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(4), GGT1(1), SHMT1(2), SHMT2(4)	1580415	12	8	12	6	3	4	2	1	2	0	0.698	0.988	1.000
145	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(2), KARS(2)	1305213	4	2	4	3	1	0	1	1	1	0	0.952	0.988	1.000
146	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	17	AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1)	4562475	22	13	19	4	3	3	5	5	6	0	0.362	0.989	1.000
147	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT2A1(1), SUOX(1)	1680152	11	3	11	4	1	2	1	4	3	0	0.685	0.989	1.000
148	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(1), ABAT(2), ADSL(2), ADSS(3), AGXT(2), AGXT2(2), ASL(3), ASNS(3), ASPA(1), CAD(6), DARS(1), DDO(2), GAD1(6), GAD2(5), GOT1(3), GPT(2), GPT2(3), PC(3)	6934256	50	24	48	11	15	9	13	6	6	1	0.0848	0.989	1.000
149	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(1), FUT2(3), FUT9(1), GBGT1(1), HEXA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2)	2825903	17	7	17	2	10	3	3	0	1	0	0.0346	0.989	1.000
150	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(5), AKT1(3), BAD(1), CSF2RB(2), IGF1R(6), IL3RA(3), KIT(4), PIK3R1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), YWHAH(1)	5384035	36	15	35	8	15	6	4	6	5	0	0.0535	0.990	1.000
151	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ASPH(2), CREB1(2), EP300(6), EPO(2), HIF1A(1), NOS3(9)	4639782	22	9	22	2	7	2	7	2	4	0	0.0580	0.990	1.000
152	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(4), LARS2(2), PDHA1(4), PDHA2(2)	2770266	14	8	12	3	4	5	2	3	0	0	0.282	0.991	1.000
153	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(1), EPX(4), LPO(6), MPO(2), MTHFR(1), SHMT1(2), SHMT2(4), TPO(7)	3242080	29	11	29	7	11	7	6	2	3	0	0.101	0.991	1.000
154	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(4), ACSS1(1), ACSS2(2), FH(3), IDH1(1), IDH2(5), MDH2(1), SUCLA2(1)	3670897	21	11	20	6	6	3	5	2	5	0	0.562	0.992	1.000
155	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), PC(3), PCK1(3), SDHA(6), SUCLA2(1), SUCLG1(3)	5728549	34	15	32	7	5	6	11	7	5	0	0.237	0.992	1.000
156	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	10	ARNTL(1), CRY1(1), CRY2(1), CSNK1D(1), CSNK1E(1), NPAS2(4), PER1(5), PER2(5), PER3(2)	4332505	21	11	19	4	3	6	3	3	6	0	0.156	0.992	1.000
157	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	13	CD3E(1), IL2RA(1), TGFB1(1), TGFB2(2)	2173470	5	4	4	5	2	0	0	0	3	0	0.993	0.992	1.000
158	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(1), SHMT1(2), SHMT2(4)	1199303	8	4	8	6	2	3	2	0	1	0	0.888	0.992	1.000
159	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(2), NFKBIA(2), RELA(3)	2573970	8	4	8	2	1	1	2	2	2	0	0.687	0.993	1.000
160	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), E2F4(3), PRB1(1)	2377911	14	3	14	3	3	3	5	3	0	0	0.295	0.993	1.000
161	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(2), ACADS(1), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH5A1(1), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), L2HGDH(2), OXCT1(2), PDHA1(4), PDHA2(2)	7184162	38	20	36	7	11	11	7	4	4	1	0.0300	0.993	1.000
162	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	6	CHRM1(1), GNAQ(1), GNB1(2), PLCB1(1), TUB(2)	1726260	7	3	7	3	1	3	0	2	1	0	0.645	0.993	1.000
163	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	16	CBL(5), EGF(4), EGFR(2), HRAS(1), PTPRB(10), RASA1(4), SHC1(2), SRC(2)	6018370	30	16	30	4	2	8	5	5	9	1	0.0885	0.993	1.000
164	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(1), GREB1(8), MTA1(1), PDZK1(1), TUBA8(4)	3131290	17	9	17	4	4	9	1	1	2	0	0.0759	0.994	1.000
165	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(1), ELK1(2), HRAS(1), IGF1R(6), MAPK8(2), PIK3R1(2), RASA1(4), SHC1(2), SRF(1)	4873997	21	13	21	5	6	2	1	3	9	0	0.312	0.994	1.000
166	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(2), PGAP1(1), PIGB(3), PIGG(2), PIGL(2), PIGM(1), PIGO(9), PIGP(2), PIGQ(6), PIGS(3), PIGW(2)	6750883	33	14	32	3	9	6	6	5	7	0	0.00658	0.994	1.000
167	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(4), PCYT1A(2), PDHA1(4), PDHA2(2), SLC18A3(3)	1985491	19	13	17	9	6	5	5	1	2	0	0.609	0.994	1.000
168	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(1), ELK1(2), HRAS(1), INSR(4), MAPK8(2), PIK3R1(2), RASA1(4), SHC1(2), SRF(1)	5083541	19	11	19	4	6	2	0	3	8	0	0.272	0.994	1.000
169	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	15	PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB10(1), PSMB5(2), PSMB6(1)	2129948	9	5	9	4	2	0	2	1	4	0	0.843	0.994	1.000
170	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), CSF3(2), HLA-DRB1(1), IL12B(1), IL6(1), IL7(1), TGFB1(1), TGFB2(2)	3750033	13	7	11	5	1	2	1	3	6	0	0.893	0.995	1.000
171	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(2), IL10RB(2), IL6(1), JAK1(1), STAT1(3), STAT3(2), STAT5A(2)	3385568	15	7	15	5	7	2	2	1	3	0	0.589	0.995	1.000
172	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(2)	1893310	21	7	20	4	7	7	0	3	4	0	0.0524	0.995	1.000
173	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	7	CDC25B(2), CDK7(1), XPO1(2)	1894486	5	4	5	2	3	0	0	0	2	0	0.673	0.995	1.000
174	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), PRKCE(1)	2212858	14	4	13	4	6	3	1	1	2	1	0.282	0.995	1.000
175	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), MUT(2)	1381953	4	2	4	2	0	1	0	1	2	0	0.814	0.995	1.000
176	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(3), CREB1(2), HRAS(1), MAPK7(4), MEF2A(2), MEF2C(2), MEF2D(2), NTRK1(3), PIK3R1(2), PLCG1(1), RPS6KA1(2), SHC1(2)	4738692	26	14	24	4	7	6	4	1	8	0	0.131	0.995	1.000
177	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	18	PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB5(2), PSMB6(1), UBE3A(6)	3303138	14	7	13	3	4	1	2	2	5	0	0.444	0.995	1.000
178	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	19	ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2)	3371418	14	6	14	4	3	4	4	1	2	0	0.426	0.995	1.000
179	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	19	ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2)	3371418	14	6	14	4	3	4	4	1	2	0	0.426	0.995	1.000
180	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	19	ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2)	3371418	14	6	14	4	3	4	4	1	2	0	0.426	0.995	1.000
181	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(2), PLCB1(1), PLCG1(1), VAV1(6)	2954919	13	5	12	5	3	3	0	3	3	1	0.713	0.995	1.000
182	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	15	ABCC1(1), ABCG2(1), BCHE(6), CES1(2), CYP3A5(1), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1)	5112647	24	18	20	7	2	4	5	5	7	1	0.645	0.996	1.000
183	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	12	AKT1(3), BAD(1), HRAS(1), IGF1R(6), PIK3R1(2), SHC1(2), YWHAH(1)	3205178	16	9	15	5	6	2	1	2	5	0	0.556	0.996	1.000
184	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(1), CR1(5), FCGR2B(2), HLA-DRB1(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3)	3601277	18	10	17	6	6	3	1	2	6	0	0.457	0.996	1.000
185	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(4), F11(1), F12(3), F13B(2), F8(9), FGA(6), FGB(4), FGG(2), LPA(8), PLAT(2), PLG(1), SERPINE1(2), SERPINF2(1), VWF(5)	8557048	50	25	46	11	14	10	12	4	9	1	0.104	0.996	1.000
186	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(7), MDM2(2), MYC(2), PIK3R1(2), POLR1A(6), POLR1B(3), RB1(3), TBX2(2)	4709654	27	12	26	4	7	5	6	2	7	0	0.0886	0.996	1.000
187	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(3), DHFR(1), IMPDH1(3), MTHFD2(1), POLB(1), POLD1(2), POLG(5), PRPS2(1), RRM1(2)	3606928	21	9	20	4	5	7	1	1	7	0	0.0954	0.996	1.000
188	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), ME1(2), PC(3), PDHA1(4), SLC25A1(1)	2584347	13	7	11	5	4	7	1	1	0	0	0.386	0.996	1.000
189	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), AFMID(2), HAO1(1), HAO2(1), MDH2(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1)	3520582	12	6	11	1	3	3	1	0	5	0	0.131	0.996	1.000
190	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(3), GLI2(5), GLI3(14), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SMO(2), SUFU(1)	4721277	41	21	40	13	18	7	7	5	4	0	0.220	0.996	1.000
191	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELL(1)	2929624	14	6	14	4	4	2	1	3	4	0	0.326	0.996	1.000
192	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	31	AARS(1), ABAT(2), ADSL(2), ADSS(3), ADSSL1(1), AGXT(2), AGXT2(2), ASL(3), ASNS(3), ASPA(1), ASRGL1(1), ASS1(4), CAD(6), DARS(1), DARS2(2), DDO(2), DLAT(4), GAD1(6), GAD2(5), GOT1(3), GPT(2), GPT2(3), NARS2(2), PC(3), PDHA1(4), PDHA2(2)	9691752	70	36	64	16	21	15	14	8	11	1	0.0347	0.997	1.000
193	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACPT(2), ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), CYP3A5(1), CYP3A7(3), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), PON1(1), PON2(1)	5058800	29	13	28	8	10	5	2	6	6	0	0.324	0.997	1.000
194	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(6), CAPN2(1), CAPNS1(3), CAPNS2(2), EP300(6), MEF2D(2), NFATC1(4), NFATC2(10), PPP3CA(3), PPP3CC(2), SYT1(1)	6774478	40	24	36	8	12	9	1	5	13	0	0.0731	0.997	1.000
195	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), EHHADH(1), GCDH(2), HADHA(1)	2167501	6	2	6	1	1	2	2	0	1	0	0.344	0.997	1.000
196	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP7(2), DFFB(1), HMGB2(1), TOP2A(2), TOP2B(6)	2559831	12	8	12	3	3	3	2	3	1	0	0.508	0.997	1.000
197	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	DLG4(3), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), NOS1(10), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1)	6749256	55	24	54	14	23	8	7	9	8	0	0.0766	0.997	1.000
198	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), FBP2(1), GOT1(3), GPT(2), GPT2(3), MDH2(1), ME1(2), ME3(2), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TKTL1(1), TPI1(3)	5622414	29	13	29	3	6	8	10	2	3	0	0.00976	0.997	1.000
199	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	10	ACE2(4), AGT(1), AGTR2(1), CMA1(1), COL4A1(5), COL4A2(6), COL4A3(2), COL4A5(5), COL4A6(6)	5884864	31	16	28	5	5	6	12	1	7	0	0.252	0.997	1.000
200	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(1), MTMR6(2), NFS1(2), PHPT1(1), TPK1(1)	1778486	7	4	7	4	3	2	1	0	1	0	0.917	0.997	1.000
201	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(5), CSF1R(5), EGF(4), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SH3KBP1(2), SRC(2)	5383141	28	13	25	4	4	7	5	3	9	0	0.158	0.998	1.000
202	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX1(1), ACOX3(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4)	2606090	10	5	10	7	2	2	3	1	2	0	0.972	0.998	1.000
203	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	AKT1(3), EGFR(2), IGF1R(6), MYC(2), POLR2A(6), PPP2CA(1), RB1(3), TERT(6), TNKS(4), XRCC5(2)	5934755	35	18	34	10	14	3	5	7	6	0	0.315	0.998	1.000
204	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAT1(2), EHHADH(1), HADHA(1), HADHB(2)	2317983	7	2	7	1	0	3	1	0	3	0	0.287	0.998	1.000
205	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(3), AKT2(2), AKT3(4), ELK1(2), HRAS(1), NGFR(1), NTRK1(3), PIK3CD(2), SHC1(2)	3267625	20	13	18	9	10	1	1	2	6	0	0.731	0.998	1.000
206	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), FGA(6), FGB(4), FGG(2), PLAT(2), PLG(1), SERPINE1(2)	3713527	20	8	19	7	3	4	5	5	3	0	0.605	0.998	1.000
207	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKBIA(2), PLCB1(1), RELA(3)	2303338	7	4	7	5	1	1	2	1	2	0	0.971	0.998	1.000
208	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	23	AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), XYLB(2)	6926702	33	17	29	6	4	7	7	8	7	0	0.207	0.998	1.000
209	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT2(2), B3GNT7(1), CHST1(1), CHST2(2), CHST4(1), CHST6(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	3321200	16	7	16	2	6	2	5	2	1	0	0.0558	0.998	1.000
210	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(5), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNB1(2), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTPRC(3), ZAP70(6)	5873012	34	13	34	6	14	7	4	4	5	0	0.0250	0.998	1.000
211	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(5), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNB1(2), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTPRC(3), ZAP70(6)	5873012	34	13	34	6	14	7	4	4	5	0	0.0250	0.998	1.000
212	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	11	ACO1(4), HAO1(1), HAO2(1), MDH2(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1)	3351290	10	5	9	0	2	3	1	0	4	0	0.0681	0.998	1.000
213	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	9	AKR1D1(1), CYP11A1(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2)	2109017	8	5	8	4	2	2	2	2	0	0	0.736	0.998	1.000
214	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	9	AKR1D1(1), CYP11A1(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2)	2109017	8	5	8	4	2	2	2	2	0	0	0.736	0.998	1.000
215	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(1), LEPR(7), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2)	4006041	17	6	17	3	2	6	1	2	6	0	0.186	0.998	1.000
216	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	HRAS(1), MMP2(2), MMP9(4), RECK(3)	1787037	10	4	9	4	5	2	1	0	2	0	0.518	0.998	1.000
217	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(2), GCK(1), GFPT1(2), GNE(2), GNPDA1(2), GNPDA2(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(4), RENBP(1)	4735333	25	12	25	7	13	4	4	1	3	0	0.241	0.998	1.000
218	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(2), ITGA4(1), ITGAL(3), ITGB2(1), SELE(2), SELL(1)	3371748	14	7	14	6	4	1	2	3	4	0	0.649	0.998	1.000
219	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GPHN(2), SRC(2), UBQLN1(3)	3369458	22	7	21	5	8	4	5	2	2	1	0.176	0.998	1.000
220	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(3), CHST12(1), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT2A1(1), SULT2B1(1), SUOX(1)	2614353	16	8	16	5	5	2	2	4	3	0	0.477	0.998	1.000
221	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	10	EPO(2), EPOR(2), HIF1A(1), JAK2(2), NFKBIA(2), RELA(3)	3108374	12	5	12	4	4	1	5	0	2	0	0.757	0.998	1.000
222	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2)	3955394	21	8	21	4	3	7	8	2	1	0	0.132	0.999	1.000
223	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(4), APAF1(3), CASP9(1), DAXX(6), FASLG(1), MAPKAPK3(1)	2972485	16	6	14	7	3	5	3	2	3	0	0.729	0.999	1.000
224	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(2), FARSB(1), GOT1(3), PAH(1), TAT(1)	2417060	10	7	9	3	3	2	4	1	0	0	0.559	0.999	1.000
225	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(3), HRAS(1), KLK2(1), NTRK1(3), PIK3R1(2), PLCG1(1), SHC1(2)	2991989	13	9	12	5	6	2	1	1	3	0	0.714	0.999	1.000
226	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3)	1731493	9	2	9	3	3	0	1	2	3	0	0.580	0.999	1.000
227	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), EHHADH(1), HADHA(1)	3389833	10	8	10	3	6	1	2	0	1	0	0.363	0.999	1.000
228	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), CREB1(2), SYT1(1)	3259789	9	5	9	2	3	0	2	0	4	0	0.467	0.999	1.000
229	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ARG2(1), ASL(3), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), OAT(2), ODC1(1), PYCR1(1)	4978972	23	7	22	2	8	3	7	3	1	1	0.0216	0.999	1.000
230	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1)	3702314	21	6	21	7	10	5	2	2	2	0	0.330	0.999	1.000
231	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(1), CASP9(1), CHUK(1), GHR(1), NFKBIA(2), PIK3R1(2), PPP2CA(1), RELA(3), YWHAH(1)	3356803	16	8	15	5	2	3	4	2	5	0	0.700	0.999	1.000
232	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3)	3822350	18	11	18	6	11	3	1	2	1	0	0.365	0.999	1.000
233	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	20	COL4A1(5), COL4A2(6), COL4A3(2), COL4A5(5), COL4A6(6), F10(4), F11(1), F12(3), F8(9), FGA(6), FGB(4), FGG(2), KLKB1(2), PROC(1), PROS1(2), SERPINC1(3), SERPING1(1)	10218919	62	27	55	10	11	13	19	3	15	1	0.0913	0.999	1.000
234	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP27B1(1), CYP51A1(1), DHCR7(1), FDFT1(2), FDPS(1), GGCX(2), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(2), NSDHL(2), SQLE(2), VKORC1(3)	5243493	31	17	29	8	11	6	8	1	5	0	0.216	0.999	1.000
235	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	11	CASR(5), GPRC5A(2), GPRC5B(5), GPRC5C(6), GRM2(5), GRM3(3), GRM4(4), GRM5(7), GRM7(5), GRM8(5)	4620970	47	21	44	13	16	13	6	5	7	0	0.0989	0.999	1.000
236	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(4), EGFR(2), HGS(2)	3566725	11	3	11	1	0	5	3	2	1	0	0.138	0.999	1.000
237	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(2), IARS(4), ILVBL(2), LARS2(2), PDHA1(4), PDHA2(2), VARS(4), VARS2(3)	5171584	25	13	23	6	10	7	3	3	2	0	0.200	0.999	1.000
238	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	16	CHUK(1), IKBKB(4), MAP3K1(3), MAP3K5(2), MAP4K5(1), MAPK8(2), NFKBIA(2), RELA(3), TRAF2(1)	5236184	19	8	19	5	2	3	5	4	5	0	0.572	0.999	1.000
239	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(3), APC(8), AXIN1(4), CD14(3), CTNNB1(9), DVL1(4), FZD1(5), GJA1(1), GNAI1(1), GSK3B(2), LBP(1), LEF1(3), LY96(1), PIK3R1(2), PPP2CA(1), RELA(3), TLR4(1), WNT1(1)	8068079	53	22	50	8	15	9	7	13	9	0	0.0221	0.999	1.000
240	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	15	CARM1(2), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2)	3714755	19	7	19	5	2	8	7	1	1	0	0.290	0.999	1.000
241	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), NAT1(2), NAT2(1), XDH(5)	2197664	18	8	18	8	8	2	1	4	3	0	0.735	0.999	1.000
242	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(3), BAD(1), BAK1(1), CASP9(1), CES1(2)	3018823	8	2	8	3	2	3	3	0	0	0	0.700	0.999	1.000
243	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(3), ATM(11), CCNE1(1), CDK4(2), MDM2(2), PCNA(1), RB1(3)	4841970	23	10	23	4	5	4	7	4	3	0	0.238	0.999	1.000
244	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), SP1(1), SP3(1), SYT1(1)	5867296	31	14	27	7	8	7	2	4	10	0	0.194	0.999	1.000
245	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(4), FURIN(2), NOTCH1(10), PSEN1(1)	2727017	17	6	17	8	8	7	1	1	0	0	0.337	0.999	1.000
246	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(3), BCAR1(2), ILK(1), PDK2(3), PIK3R1(2), PTEN(2), PTK2(3), SHC1(2)	4088883	18	9	17	4	6	4	3	1	4	0	0.251	0.999	1.000
247	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), DDC(1), EPX(4), GOT1(3), HPD(3), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), TAT(1), TPO(7)	6156453	44	20	43	8	19	7	10	3	5	0	0.0152	1.000	1.000
248	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), ASRGL1(1), CA5A(3), CA5B(2), CA6(1), CA8(1), CA9(1), CPS1(5), GLS(1), GLUD2(3), HAL(1)	5914428	22	11	21	5	4	8	3	2	4	1	0.312	1.000	1.000
249	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(8), AXIN1(4), BTRC(2), CREBBP(3), CSNK1A1(1), CSNK1D(1), CSNK2A1(1), CTNNB1(9), DVL1(4), FZD1(5), GSK3B(2), MYC(2), NLK(2), PPARD(2), PPP2CA(1), TLE1(3), WIF1(2), WNT1(1)	8030887	53	23	53	9	13	11	10	10	9	0	0.0252	1.000	1.000
250	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), FUT1(1), FUT2(3), FUT9(1), GBGT1(1), HEXA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2)	2995892	15	7	15	3	8	3	3	0	1	0	0.121	1.000	1.000
251	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(3), EP300(6), ESR1(1), SRC(2)	4210565	12	7	12	3	3	3	4	1	1	0	0.321	1.000	1.000
252	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3), THY1(1)	2968478	13	5	13	3	7	1	0	2	3	0	0.215	1.000	1.000
253	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(1), CDC34(1), CUL1(4), RB1(3), SKP2(3), TFDP1(1)	2406145	16	8	16	8	3	5	4	3	1	0	0.829	1.000	1.000
254	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(2), ITGA4(1), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELL(1), SELP(3)	4461888	18	8	18	7	5	3	2	3	5	0	0.485	1.000	1.000
255	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(4), RB1(3), SKP2(3), TFDP1(1)	2396592	12	7	12	6	2	3	3	3	1	0	0.865	1.000	1.000
256	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH18A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AMD1(1), AOC2(3), AOC3(3), ARG1(1), ARG2(1), ASL(3), ASS1(4), CPS1(5), ODC1(1), SAT2(1)	8279665	30	16	28	3	17	4	4	2	2	1	0.00407	1.000	1.000
257	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(2), CREBBP(3), EP300(6), NCOA3(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RXRA(1)	5765837	26	13	26	8	9	4	6	3	3	1	0.351	1.000	1.000
258	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(3), JAK1(1), JAK2(2), TYK2(2)	2909471	8	5	8	4	2	0	3	1	2	0	0.897	1.000	1.000
259	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(3), JAK1(1), JAK2(2), TYK2(2)	2909471	8	5	8	4	2	0	3	1	2	0	0.897	1.000	1.000
260	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(4), BAIAP2(4), CASP1(4), CASP7(2), CASP8(2), INSR(4), ITCH(3), MAGI1(2), MAGI2(12), WWP1(2), WWP2(6)	5939029	45	25	40	13	15	7	4	7	12	0	0.340	1.000	1.000
261	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(1), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SRF(1), STAT1(3), STAT3(2), STAT5A(2)	8386078	35	17	35	8	9	5	4	6	11	0	0.307	1.000	1.000
262	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	2411659	7	3	7	5	3	0	2	0	2	0	0.901	1.000	1.000
263	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD4(2), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3), THY1(1)	3117056	15	5	15	4	7	1	0	3	4	0	0.317	1.000	1.000
264	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(2), CD3E(1), CD4(2), IL12B(1), IL12RB1(1), IL12RB2(2), JAK2(2), STAT4(1), TYK2(2)	4135444	14	6	14	6	2	1	3	2	6	0	0.902	1.000	1.000
265	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), ESCO1(3), SH3GLB1(1)	4262085	10	5	10	2	2	2	1	3	2	0	0.398	1.000	1.000
266	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD3E(1), CD80(1), HLA-DRB1(1), ITK(1), LCK(1), PIK3R1(2)	2739290	7	3	7	4	2	1	1	1	2	0	0.901	1.000	1.000
267	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	10	COL4A1(5), COL4A2(6), COL4A3(2), COL4A5(5), COL4A6(6), SLC2A1(3)	6109634	27	12	24	8	5	5	9	1	7	0	0.684	1.000	1.000
268	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(1), ELK1(2), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3R1(2), PLCG1(1), SHC1(2)	4003737	13	7	13	3	4	3	1	1	4	0	0.282	1.000	1.000
269	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(3), CCND2(3), CCND3(1), CCNE1(1), CDK4(2), CDK6(2), CDK7(1), RB1(3), RBL1(1), TFDP1(1)	4090298	18	6	18	6	2	5	5	4	2	0	0.505	1.000	1.000
270	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	11	ARF1(2), ARFGAP1(2), ARFGEF2(3), CLTB(1), COPA(6), GBF1(3), GPLD1(2), KDELR2(1)	4214443	20	9	18	7	5	3	3	4	4	1	0.593	1.000	1.000
271	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(2), GSK3B(2), PPP1CA(1)	3225117	11	3	11	4	2	3	4	0	2	0	0.702	1.000	1.000
272	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), GSS(1), NOX1(4), RELA(3), XDH(5)	2786464	14	7	14	7	5	3	3	2	1	0	0.849	1.000	1.000
273	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(7), AKT1(3), ATM(11), CSNK1A1(1), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), HSPA1A(1), MAPK8(2), MDM2(2), NFKBIB(1), NQO1(2)	5621445	35	20	33	10	6	4	8	9	8	0	0.477	1.000	1.000
274	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	BLVRA(2), CP(5), CPOX(3), EPRS(1), GUSB(1), HMBS(1), PPOX(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1)	7265463	31	17	28	5	4	5	4	7	11	0	0.267	1.000	1.000
275	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(4), FH(3), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), OGDH(5), PC(3), PDHA1(4), PDHA2(2), PDK1(1), PDK2(3), PDK4(1), SDHA(6), SUCLA2(1), SUCLG1(3)	7938626	46	19	43	10	9	10	13	8	6	0	0.112	1.000	1.000
276	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(3), HK2(3), HK3(4), ISYNA1(1), PGM1(1), TGDS(1)	3276862	14	7	14	5	9	1	2	0	2	0	0.350	1.000	1.000
277	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(3), FBL(1), GPT(2), LDHB(1), NCL(2)	2528350	12	3	11	6	3	1	5	1	2	0	0.885	1.000	1.000
278	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS1(3), SCAP(3), SREBF2(5)	3485307	12	8	10	8	4	2	0	2	4	0	0.944	1.000	1.000
279	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), HRAS(1), MYC(2), NFKBIA(2), PLCB1(1), RELA(3)	4325454	11	6	11	5	2	2	3	1	3	0	0.935	1.000	1.000
280	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(3), BAD(1), CASP9(1), CDC42(1), CHUK(1), ELK1(2), HRAS(1), PIK3R1(2), RALBP1(2), RALGDS(2), RELA(3), RHOA(1)	4679415	20	11	19	8	5	4	3	3	5	0	0.771	1.000	1.000
281	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	HLA-A(7), KLRC3(2), KLRC4(1), PIK3R1(2), PTPN6(4), SYK(2), VAV1(6)	4254260	24	11	23	9	7	3	4	6	3	1	0.675	1.000	1.000
282	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(7), NT5E(1), NT5M(1)	4055340	20	7	20	6	7	3	5	3	2	0	0.374	1.000	1.000
283	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(1), EGF(4), EGFR(2), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SRF(1), STAT1(3), STAT3(2), STAT5A(2)	9090550	38	19	38	9	7	7	5	7	12	0	0.326	1.000	1.000
284	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	23	ADCY1(5), AKT1(3), CAMK2D(1), CREB1(2), HRAS(1), PIK3R1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RPS6KA1(2), RPS6KA5(4)	6195070	29	15	26	9	10	4	2	3	10	0	0.587	1.000	1.000
285	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(3), ANXA6(3), CYP11A1(2), EDNRB(2), HSD11B1(1), PRL(4), PTGDR(2), PTGDS(2), PTGFR(2), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1)	5716991	27	12	27	9	12	2	6	6	1	0	0.458	1.000	1.000
286	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(2), RELA(3), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(2), TRAF2(1), TRAF5(1), TRAF6(1)	4098821	13	4	13	4	2	1	5	1	4	0	0.718	1.000	1.000
287	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3), MASP1(2)	5970004	48	22	46	11	11	7	9	8	13	0	0.119	1.000	1.000
288	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), ASPA(1), CNDP1(2), DDC(1), HAL(1), HDC(1), PRPS1(1), PRPS2(1)	6815696	26	18	26	5	12	5	4	2	3	0	0.0577	1.000	1.000
289	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(3), BIRC2(2), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1), LMNB1(1), LMNB2(1)	5086465	24	10	23	4	5	5	5	2	7	0	0.235	1.000	1.000
290	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	B3GNT2(2), B3GNT3(2), B3GNT4(1), B3GNT5(1), FUT1(1), FUT2(3), FUT3(1), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GCNT2(1), ST8SIA1(2)	4386976	19	9	19	3	10	4	3	0	2	0	0.0561	1.000	1.000
291	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(1), ETV5(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), JAK2(2), MAP2K6(3), MAPK8(2), STAT4(1), TYK2(2)	5232124	18	9	18	6	4	1	4	1	8	0	0.672	1.000	1.000
292	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(6), CTNNB1(9), PTK2(3), PXN(1), SRC(2), VCL(3)	5463774	36	12	36	4	16	10	1	8	1	0	0.00144	1.000	1.000
293	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(1), ELK1(2), EPO(2), EPOR(2), HRAS(1), JAK2(2), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(2), STAT5A(2)	5304323	21	7	21	6	7	2	4	2	6	0	0.413	1.000	1.000
294	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(2), ATG7(3), BECN1(3), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(1), ULK1(3), ULK3(1)	5960733	25	11	24	6	6	6	1	7	5	0	0.305	1.000	1.000
295	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	20	PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB5(2), PSMB6(1), PSMD1(4), PSMD11(2), PSMD12(2), PSMD2(1)	4134660	17	8	17	7	4	2	4	3	4	0	0.804	1.000	1.000
296	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(2), AKT3(4), BPNT1(2), ILK(1), PDK1(1), PIK3CD(2), PTEN(2), RBL2(2), SHC1(2)	4337790	21	11	19	9	7	2	3	4	5	0	0.795	1.000	1.000
297	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(3), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(2), PIK3R1(2), RB1(3), RELA(3), TFDP1(1)	4743369	20	9	19	9	4	3	6	3	4	0	0.912	1.000	1.000
298	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(4), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), OGDH(5), OGDHL(2), PC(3), PCK1(3), PCK2(5), SDHA(6), SUCLA2(1), SUCLG1(3)	8286680	49	22	45	13	12	7	12	8	9	1	0.307	1.000	1.000
299	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	15	CARS2(2), GOT1(3), LDHAL6B(2), LDHB(1), SULT1C4(1), SULT4A1(1)	3234666	10	4	10	5	1	2	3	2	2	0	0.862	1.000	1.000
300	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(2), KARS(2)	1921201	6	2	6	3	1	0	3	1	1	0	0.905	1.000	1.000
301	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(3), APAF1(3), ATM(11), BAD(1), CASP7(2), CASP9(1), PTK2(3), PXN(1), STAT1(3), TLN1(11)	7301258	39	15	38	8	11	9	6	7	6	0	0.127	1.000	1.000
302	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(2), HDAC5(2), MEF2A(2), MEF2C(2), MEF2D(2), PPARA(1), PPP3CA(3), PPP3CC(2), SYT1(1), YWHAH(1)	5710031	24	11	24	6	5	5	5	3	6	0	0.261	1.000	1.000
303	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(2), HRAS(1), IL3RA(3), JAK2(2), PTPN6(4), SHC1(2), STAT5A(2)	4186652	16	8	16	7	7	1	3	2	3	0	0.769	1.000	1.000
304	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CHUK(1), EGR3(2), GNAQ(1), MAP3K1(3), MYC(2), NFATC1(4), NFATC2(10), NFKBIA(2), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RELA(3), SYT1(1), VIPR2(1)	7565767	45	21	41	12	14	7	5	6	13	0	0.270	1.000	1.000
305	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	20	ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2)	3639005	14	6	14	6	3	4	4	1	2	0	0.666	1.000	1.000
306	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(11), CCND2(3), CDK4(2), ESR2(3), FSHR(4), GJA4(2), LHCGR(2), MLH1(1), NCOR1(9), NRIP1(1), PGR(4), PRLR(2), SMPD1(1), ZP2(1)	9495867	46	21	46	9	13	6	12	8	7	0	0.0731	1.000	1.000
307	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(3), ANAPC2(4), ANAPC4(3), ANAPC5(6), ANAPC7(1), BTRC(2), CDC16(1), CDC20(1), CDC23(2), CUL1(4), CUL2(2), CUL3(1), FBXW11(2), FBXW7(6), ITCH(3), SKP1(1), SKP2(3), SMURF2(1), TCEB1(2), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(2), WWP1(2), WWP2(6)	10837481	61	30	59	15	18	11	12	8	12	0	0.225	1.000	1.000
308	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	26	ACTA1(4), AKT1(3), BDKRB2(1), CHRM1(1), CHRNA1(4), FLT1(4), FLT4(11), KDR(1), NOS3(9), PDE2A(1), PDE3B(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKG1(1), PRKG2(2), SLC7A1(1), SYT1(1), TNNI1(1)	8354474	55	25	54	10	25	7	10	3	10	0	0.00380	1.000	1.000
309	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), JAK3(3), STAT3(2), TYK2(2)	3330983	10	4	10	9	3	2	3	0	2	0	0.981	1.000	1.000
310	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA5A(3), CA5B(2), CA6(1), CA8(1), CA9(1), CPS1(5), GLS(1), HAL(1)	5286534	18	8	17	4	3	6	2	2	4	1	0.396	1.000	1.000
311	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKM(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RBKS(1), RPE(2), RPIA(1), TALDO1(1), TKT(1)	5708618	30	13	30	9	12	4	8	3	3	0	0.223	1.000	1.000
312	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(1), BIK(1), BIRC2(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1)	3664484	13	4	13	4	2	3	3	2	3	0	0.591	1.000	1.000
313	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	19	CHUK(1), CREBBP(3), EP300(6), IKBKB(4), IL1B(1), MAP2K3(1), MAP2K6(3), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(3), TLR2(2)	7408097	29	13	29	8	7	5	8	2	7	0	0.314	1.000	1.000
314	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	11	ACAA1(1), ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL6(1), FADS1(1), FASN(7), HADHA(1), HSD17B12(1)	3714310	16	6	16	5	5	4	4	0	2	1	0.246	1.000	1.000
315	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	19	ATM(11), ATR(10), BRCA1(6), CDC25B(2), CDC34(1), CHEK2(1), EP300(6), MDM2(2), MYT1(12), PRKDC(9), RPS6KA1(2), YWHAH(1)	11055038	63	33	60	12	13	9	11	13	17	0	0.140	1.000	1.000
316	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(3), BIRC2(2), CASP10(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1), SCAP(3), SREBF2(5)	4934676	21	10	19	6	5	5	2	2	7	0	0.438	1.000	1.000
317	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(6), CPS1(5), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(2), GLS(1), GOT1(3), GPT(2), GPT2(3), GSS(1), NADSYN1(4), PPAT(2), QARS(2)	9262877	51	20	51	12	10	11	15	6	7	2	0.154	1.000	1.000
318	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(3), LDHB(1)	1906164	4	2	4	2	1	0	2	1	0	0	0.898	1.000	1.000
319	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	5	IFNGR1(2), JAK1(1), JAK2(2), STAT1(3)	2089635	8	5	8	4	2	0	3	2	1	0	0.870	1.000	1.000
320	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATM(11), ATR(10), BRCA1(6), BRCA2(14), CHEK2(1), FANCA(5), FANCC(2), FANCD2(8), FANCG(1), HUS1(1), MRE11A(4), RAD50(1), TREX1(2)	11574751	66	34	57	12	8	11	11	9	27	0	0.307	1.000	1.000
321	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(2), AKT3(4), ARHGEF11(6), CDC42(1), DLG4(3), LPA(8), MAP2K4(5), MAP3K1(3), MAP3K5(2), MAPK8(2), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(7), PIK3CB(3), PLD2(5), PLD3(2), PTK2(3), RDX(4), ROCK1(6), ROCK2(2), SRF(1), TBXA2R(1)	13790702	79	40	74	19	17	13	15	14	20	0	0.163	1.000	1.000
322	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(1), ASL(3), ASS1(4), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), EPRS(1), GLUD2(3), GOT1(3), LAP3(2), NOS1(10), NOS3(9), OAT(2), P4HA1(5), P4HA2(2), P4HA3(2), PARS2(2), PRODH(2), PYCR1(1), RARS(1), RARS2(4)	10102622	76	34	74	13	28	12	19	8	8	1	0.00643	1.000	1.000
323	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1), SYT1(1)	3848791	8	3	8	7	0	2	1	2	3	0	0.942	1.000	1.000
324	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	15	ACE2(4), AGT(1), AGTR2(1), ANPEP(3), CMA1(1), CPA3(1), CTSG(2), ENPEP(3), LNPEP(2), MME(2), NLN(1), THOP1(1)	4960489	22	8	22	6	3	7	7	4	1	0	0.266	1.000	1.000
325	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), ESCO1(3), SH3GLB1(1)	6600642	27	7	27	7	8	8	2	5	4	0	0.219	1.000	1.000
326	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(1), HRAS(1), JAK2(2), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), STAT1(3), STAT3(2), STAT5A(2), THPO(1)	6983448	21	11	21	6	5	4	2	2	8	0	0.628	1.000	1.000
327	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(4), ACAT1(2), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), HAGH(2), LDHB(1), MDH2(1), ME1(2), ME2(4), ME3(2), PC(3), PCK1(3), PDHA1(4), PDHA2(2), PKLR(2)	10102048	49	21	47	9	13	22	5	3	6	0	0.00856	1.000	1.000
328	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(6), CPS1(5), EARS2(1), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLUD2(3), GOT1(3), GPT(2), GPT2(3), GSR(1), GSS(1), NADSYN1(4), NAGK(1), PPAT(2), QARS(2)	11030353	59	23	59	14	11	13	19	7	7	2	0.122	1.000	1.000
329	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TNFAIP3(2), TRAF6(1)	5092817	19	7	19	7	2	5	7	2	3	0	0.727	1.000	1.000
330	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(5), AKT1(3), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(4), ITGB3(1), PDGFRA(3), PIK3R1(2), PLCB1(1), PTK2(3), SMPD1(1), SPHK1(1), SRC(2)	7026905	30	10	29	6	8	10	2	4	6	0	0.0907	1.000	1.000
331	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), GCK(1), GMDS(1), GMPPA(5), HK1(3), HK2(3), HK3(4), PFKFB1(2), PFKFB3(1), PFKFB4(3), PFKM(3), PFKP(1), PMM2(2), TPI1(3)	6703874	37	17	37	11	18	6	9	2	2	0	0.148	1.000	1.000
332	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(2), AGT(1), AGTR2(1), EDNRB(2), EGF(4), EGFR(2), HRAS(1), MYC(2), PLCG1(1), RELA(3)	5598666	19	8	19	6	3	4	5	1	6	0	0.639	1.000	1.000
333	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AOC2(3), AOC3(3), CES1(2), DDHD1(3), ESCO1(3), LIPA(1), PLA1A(2), SH3GLB1(1)	6717608	18	9	18	3	6	3	5	3	1	0	0.146	1.000	1.000
334	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(4), EXTL1(3), EXTL2(2), EXTL3(6), GLCE(2), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), NDST1(3), NDST3(3), NDST4(3)	5896020	36	12	36	9	13	7	10	3	3	0	0.122	1.000	1.000
335	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CYP2C9(2), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), EHHADH(1), ESCO1(3), HADHA(1), SH3GLB1(1)	8269781	21	12	21	6	9	3	3	3	3	0	0.336	1.000	1.000
336	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(2), ACADS(1), ACAT1(2), ACSM1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH5A1(1), BDH1(2), BDH2(1), DDHD1(3), EHHADH(1), GAD1(6), GAD2(5), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(2), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(2), PLA1A(2), RDH11(2)	11371578	58	26	56	11	15	15	13	9	5	1	0.0120	1.000	1.000
337	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	10	APC(8), CDH1(1), CREBBP(3), EP300(6), SKIL(1), TGFB1(1), TGFB2(2)	6190356	22	13	21	8	6	2	6	3	5	0	0.760	1.000	1.000
338	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKL(2), PFKM(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RBKS(1), RPE(2), RPIA(1), TALDO1(1), TKT(1), TKTL1(1)	6814642	33	14	33	8	13	5	8	3	4	0	0.106	1.000	1.000
339	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(7), NT5C1B(3), NT5E(1), NT5M(1), NUDT12(1)	5695242	24	8	24	8	8	3	7	3	3	0	0.478	1.000	1.000
340	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), MANBA(2), NEU4(2)	4699040	20	11	20	7	7	3	4	0	6	0	0.526	1.000	1.000
341	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(4), APC(8), AXIN1(4), BTRC(2), CTNNB1(9), DVL1(4), FZD1(5), GSK3B(2), NOTCH1(10), PSEN1(1), WNT1(1)	6166393	50	17	50	10	17	15	6	9	3	0	0.0109	1.000	1.000
342	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	19	ARHGAP5(6), DIAPH1(7), HRAS(1), ITGA1(7), MYLK(11), PIK3R1(2), PTK2(3), PXN(1), ROCK1(6), SHC1(2), SRC(2), TLN1(11)	9071892	59	23	59	12	18	17	8	7	8	1	0.0307	1.000	1.000
343	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(8), AXIN1(4), CREBBP(3), CTNNB1(9), DVL1(4), EP300(6), FZD1(5), GSK3B(2), LDB1(2), LEF1(3), TRRAP(11), WNT1(1)	9286604	58	21	57	12	20	10	9	13	6	0	0.0276	1.000	1.000
344	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	9	B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	2016705	7	2	7	2	3	0	3	1	0	0	0.560	1.000	1.000
345	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(1), ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1D1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), BAAT(1), CYP27A1(3), CYP7A1(2), HADHB(2)	6165623	31	12	31	10	12	7	5	3	4	0	0.324	1.000	1.000
346	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(3), CPO(2), HBB(1), HMBS(1)	2254333	7	5	7	4	4	1	1	0	1	0	0.788	1.000	1.000
347	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3)	4694728	22	6	22	3	7	6	5	1	3	0	0.0509	1.000	1.000
348	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(2), ACOT11(1), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), EHHADH(1), ESCO1(3), GCDH(2), HADHA(1), SH3GLB1(1)	6883212	17	7	17	3	4	4	3	3	3	0	0.174	1.000	1.000
349	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(2), RELA(3), TANK(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	6882445	38	14	38	10	10	6	9	5	8	0	0.265	1.000	1.000
350	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(2), MAP2K4(5), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(3), SMPD1(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	5793492	22	9	22	8	6	1	5	4	6	0	0.768	1.000	1.000
351	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(5), DDX20(1), E2F4(3), ETS1(3), ETS2(2), HDAC5(2), HRAS(1), NCOR2(5), RBL1(1), RBL2(2), SIN3A(6)	7447741	33	15	30	10	6	7	7	5	8	0	0.424	1.000	1.000
352	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BIRC2(2), CASP10(2), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), DFFB(1), GAS2(4), NFKBIA(2), RELA(3), SPTAN1(3), TNFRSF10A(2), TNFRSF10B(2), TNFSF12(2), TRADD(1), TRAF2(1)	9463044	37	15	37	8	12	7	6	3	9	0	0.133	1.000	1.000
353	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(7), ATM(11), ATR(10), CCNA1(3), CCNE1(1), CDK4(2), CDK6(2), DHFR(1), GSK3B(2), RB1(3), SKP2(3), TFDP1(1), TGFB1(1), TGFB2(2)	7769480	49	22	47	14	7	9	12	7	14	0	0.555	1.000	1.000
354	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(5), CREB1(2), ELK1(2), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1)	9223638	51	22	47	11	17	12	2	7	13	0	0.0444	1.000	1.000
355	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), MAN2B1(2), MAN2B2(2), MANBA(2), NEU4(2)	5782790	24	13	24	9	9	3	5	0	7	0	0.511	1.000	1.000
356	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2M1(1), ARF1(2), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(2), GSK3B(2), LYN(1), PFKL(2), PFKM(3), PFKP(1), PLCG1(1), PRKCE(1)	7157597	25	10	23	7	7	8	3	2	5	0	0.246	1.000	1.000
357	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(9), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAR2B(1), PRKCE(1)	5042466	21	8	21	9	6	4	4	5	2	0	0.820	1.000	1.000
358	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GHR(1), HRAS(1), INSR(4), JAK2(2), PIK3R1(2), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(2), SRF(1), STAT5A(2)	7192159	22	10	21	7	8	2	4	2	6	0	0.652	1.000	1.000
359	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(4), F2RL1(2), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(2), PLD2(5), PLD3(2), PTK2(3), RASAL1(6), SRC(2), TEC(2), VAV1(6)	7752533	47	15	44	12	15	12	7	4	8	1	0.0855	1.000	1.000
360	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(2), ACACA(4), ACADL(2), ACADM(2), ACADSB(3), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3)	9192870	34	14	34	6	9	8	5	6	6	0	0.0831	1.000	1.000
361	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(4), ERBB4(6), PSEN1(1)	2533711	11	3	11	5	1	5	1	3	1	0	0.778	1.000	1.000
362	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(5), ARHGEF1(3), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(2), PIK3R1(2), PLCB1(1), PPP1R12B(1), ROCK1(6)	6318013	23	11	23	9	4	8	3	3	5	0	0.615	1.000	1.000
363	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	37	APAF1(3), BAK1(1), BIRC2(2), CASP2(3), CASP7(2), CASP8(2), CASP9(1), FASLG(1), MAP2K4(5), MAP3K1(3), MAPK10(1), MDM2(2), MYC(2), NFKBIA(2), PARP1(8), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	9686217	46	22	43	14	9	4	13	6	13	1	0.719	1.000	1.000
364	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(2), AKT1(3), AKT2(2), AKT3(4), BAD(1), BTK(1), DAPP1(2), GSK3A(2), GSK3B(2), IARS(4), INPP5D(1), PDK1(1), PPP1R13B(1), PTEN(2), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS2(1), TEC(2), YWHAE(3), YWHAH(1)	8601872	41	20	37	12	13	8	2	7	11	0	0.334	1.000	1.000
365	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	26	CCL3(1), CCR1(2), CCR2(1), CCR4(4), CCR7(1), CD4(2), CXCR4(3), IFNGR1(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL4R(3), TGFB1(1), TGFB2(2)	5220583	27	15	26	10	5	4	4	4	10	0	0.805	1.000	1.000
366	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	9	CREBBP(3), DFFB(1), HMGB2(1), NME1(1), SET(1)	2490051	7	4	7	4	2	1	2	1	1	0	0.805	1.000	1.000
367	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), ASPA(1), CARM1(2), CNDP1(2), DDC(1), FTCD(2), HAL(1), HDC(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRPS1(1), PRPS2(1), UROC1(5)	10875696	46	21	45	9	14	10	12	4	6	0	0.0277	1.000	1.000
368	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	18	ALG5(1), B4GALT5(2), DDOST(1), MAN1A1(2), MAN1B1(2), MGAT1(1), MGAT3(3), MGAT4B(1), MGAT5(2), ST6GAL1(1)	4923225	16	8	15	9	8	1	1	4	2	0	0.880	1.000	1.000
369	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(4), ACACB(8), ACAT1(2), ACOT12(3), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), HAGH(2), LDHAL6B(2), LDHB(1), MDH2(1), ME1(2), ME2(4), ME3(2), PC(3), PCK1(3), PCK2(5), PDHA1(4), PDHA2(2), PKLR(2)	12818187	66	29	62	15	21	22	6	4	12	1	0.0219	1.000	1.000
370	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(3), GPI(3), HK1(3), HK2(3), HK3(4), LDHAL6B(2), LDHB(1), MDH2(1), PC(3), PCK1(3), PDHA1(4), PDHA2(2), PFKL(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PKLR(2), TPI1(3)	11801608	61	25	59	13	25	17	10	4	5	0	0.00700	1.000	1.000
371	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(3), AKT2(2), AKT3(4), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(7), PIK3CB(3), PLD2(5), PLD3(2)	12686371	75	42	65	18	24	11	10	7	23	0	0.168	1.000	1.000
372	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MIOX(1), OCRL(1), PIK3C2A(5), PIK3C2B(12), PIK3CB(3), PIK3CG(5), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7)	12008972	60	24	58	14	22	8	6	10	14	0	0.100	1.000	1.000
373	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), CABIN1(6), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1R(6), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(2), MEF2C(2), MEF2D(2), NFATC1(4), NFATC2(10), PIK3R1(2), PPP3CA(3), PPP3CC(2), SYT1(1), YWHAH(1)	9175343	60	26	55	14	18	11	8	6	17	0	0.0543	1.000	1.000
374	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	ANKHD1(4), EEF1A2(1), EEF1D(1), EEF1G(3), EEF2(6), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B2(3), EIF2B3(2), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(8), EIF4G3(7), EIF5(2), ETF1(1), GSPT2(1), PABPC3(5), SLC35A4(2)	11360660	57	23	55	12	12	14	14	7	10	0	0.125	1.000	1.000
375	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG2(3), AKT1(3), ANGPTL2(2), CDC42(1), FLNA(10), FLNC(12), FSCN1(1), FSCN3(3), GDI1(1), GDI2(3), LIMK1(1), MYH2(4), MYLK(11), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PAK7(1), ROCK1(6), ROCK2(2), WASF1(1), WASL(6)	13230122	81	39	78	24	20	15	15	12	19	0	0.297	1.000	1.000
376	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	49	AKR1D1(1), ARSE(1), CARM1(2), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD3B1(2), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), STS(4), SULT2A1(1), SULT2B1(1), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	12686761	58	27	53	14	9	17	15	10	7	0	0.122	1.000	1.000
377	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	45	ADCY4(2), ADCY6(3), ADCY8(4), CACNA1A(9), CACNA1B(12), GNB1(2), GNB3(2), GNG13(1), GRM4(4), ITPR3(10), PLCB2(5), PRKACB(1), PRKACG(3), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R2(3), TAS1R3(2), TAS2R1(4), TAS2R10(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R4(4), TAS2R41(1), TAS2R42(1), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(1)	14827491	92	38	90	23	36	14	15	13	14	0	0.00698	1.000	1.000
378	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1)	5840646	22	13	22	8	11	4	2	2	3	0	0.518	1.000	1.000
379	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), DDC(1), EPX(4), ESCO1(3), GOT1(3), HPD(3), LPO(6), MPO(2), SH3GLB1(1), TAT(1), TPO(7)	9215147	44	17	44	7	20	6	9	5	4	0	0.00972	1.000	1.000
380	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(3), EP300(6), IKBKB(4), NFKBIA(2), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6318203	24	12	24	9	6	4	8	2	4	0	0.665	1.000	1.000
381	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(4), ACACB(8), FASN(7), MCAT(1), OXSM(1)	4414873	21	5	21	5	8	6	4	1	1	1	0.0890	1.000	1.000
382	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(8), ASAH1(1), CAMP(2), CERK(1), CREB1(2), CREB5(1), DAG1(2), EPHB2(4), GNAQ(1), ITPKB(3), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1)	8142870	45	19	45	12	14	5	7	9	10	0	0.197	1.000	1.000
383	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPT(2), ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2D6(1), CYP2E1(3), CYP2F1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), CYP4B1(1), CYP51A1(1), PON1(1)	8186065	58	25	55	18	21	7	11	9	10	0	0.298	1.000	1.000
384	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	29	ARHGAP4(2), ARHGAP5(6), ARHGAP6(3), ARHGEF1(3), ARHGEF11(6), ARHGEF5(4), ARPC1A(2), ARPC2(1), BAIAP2(4), DIAPH1(7), LIMK1(1), MYLK(11), PIP5K1B(2), PPP1R12B(1), ROCK1(6), SRC(2), TLN1(11), VCL(3)	12484829	75	32	73	18	21	19	11	10	13	1	0.0386	1.000	1.000
385	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(7), ACTB(2), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(3), CDC42(1), CDH1(1), CTNNB1(9), CTTN(2), HCLS1(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(6), ROCK2(2), TLR4(1), TLR5(3), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4), WASL(6)	14331615	91	42	86	18	29	17	11	13	21	0	0.0146	1.000	1.000
386	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(7), ACTB(2), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(3), CDC42(1), CDH1(1), CTNNB1(9), CTTN(2), HCLS1(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(6), ROCK2(2), TLR4(1), TLR5(3), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4), WASL(6)	14331615	91	42	86	18	29	17	11	13	21	0	0.0146	1.000	1.000
387	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(1), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(3), WDR1(2)	2764672	13	3	13	5	4	2	1	5	1	0	0.566	1.000	1.000
388	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR2(1), ATP8A1(3), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKBR(3), CCR1(2), CCR10(2), CCR2(1), CCR4(4), CCR7(1), CX3CR1(1), CXCR4(3), EDNRB(2), FPR1(2), FSHR(4), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(2), MC2R(2), MC3R(4), MC5R(3), NMBR(1), NPY1R(3), NPY2R(3), NPY5R(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(2), SSTR1(4), SSTR3(2), SSTR4(3), TACR1(3), TACR2(1), TACR3(4), TRHR(2), TSHR(3)	14205821	92	37	90	29	34	13	22	12	10	1	0.0707	1.000	1.000
389	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH4A1(3), AMD1(1), AOC2(3), AOC3(3), ARG1(1), ARG2(1), ASL(3), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), GOT1(3), NOS1(10), NOS3(9), OAT(2), ODC1(1), P4HA1(5), P4HA2(2), P4HA3(2), PYCR1(1), RARS(1)	12412093	74	30	73	9	32	13	17	6	5	1	0.000103	1.000	1.000
390	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), GALNT1(3), GALNT10(6), GALNT13(2), GALNT14(1), GALNT2(2), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT4(1), OGT(2), ST3GAL1(2), ST3GAL2(1), WBSCR17(2)	8985944	36	18	35	10	12	6	9	4	5	0	0.299	1.000	1.000
391	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(3), BCR(2), CRKL(2), HRAS(1), JAK2(2), MAP2K4(5), MAP3K1(3), MAPK8(2), MYC(2), PIK3R1(2), STAT1(3), STAT5A(2)	6482323	29	16	28	10	8	1	5	6	9	0	0.816	1.000	1.000
392	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(8), GAL3ST1(1), GALC(2), GBA(4), GLB1(2), LCT(6), NEU4(2), PPAP2B(2), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD1(1), SMPD3(1), SMPD4(3), SPHK1(1), SPHK2(1), SPTLC1(3), SPTLC2(1), UGCG(1), UGT8(1)	10145079	50	25	47	14	20	11	5	7	7	0	0.0496	1.000	1.000
393	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADL(2), ACADM(2), ACADS(1), ACADSB(3), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), BCAT1(2), BCKDHA(4), BCKDHB(2), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2)	10018499	46	19	44	6	13	12	7	4	10	0	0.00463	1.000	1.000
394	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	29	APC(8), AXIN1(4), BMP2(3), BMP4(2), BMP5(3), BMP7(2), BMPR1A(4), BMPR2(3), CHRD(2), CTNNB1(9), DVL1(4), FZD1(5), GATA4(1), GSK3B(2), MEF2C(2), NKX2-5(1), RFC1(4), TGFB1(1), TGFB2(2), WNT1(1)	9333488	63	25	62	10	23	13	8	12	7	0	0.00534	1.000	1.000
395	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	39	CD3E(1), ELK1(2), HRAS(1), LCK(1), MAP2K4(5), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKBIA(2), PIK3R1(2), PLCG1(1), PPP3CA(3), PPP3CC(2), RASA1(4), RELA(3), SHC1(2), SYT1(1), VAV1(6), ZAP70(6)	11709711	68	28	64	14	18	13	7	10	19	1	0.0474	1.000	1.000
396	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(3), CAPNS2(2), ITGA1(7), ITGB3(1), PTK2(3), PXN(1), SPTAN1(3), SRC(2), TLN1(11)	8031855	43	11	43	6	15	13	5	4	6	0	0.00228	1.000	1.000
397	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	CANX(2), CD4(2), CD8B(2), CREB1(2), CTSB(2), CTSS(2), HLA-A(7), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(3), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL3(2), KIR3DL1(3), KLRC3(2), KLRC4(1), LGMN(1), NFYC(1), PDIA3(2), RFX5(1), TAP1(4), TAP2(1), TAPBP(1)	12187438	56	30	55	16	8	15	8	12	13	0	0.277	1.000	1.000
398	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(3), AKT2(2), AKT3(4), APC(8), AXIN1(4), AXIN2(1), CSNK1A1(1), CTNNB1(9), DACT1(4), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(2), GSK3B(2), LRP1(21), MVP(3), NKD1(4), NKD2(1), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(2), WIF1(2)	11489728	83	37	80	17	31	15	12	12	13	0	0.0133	1.000	1.000
399	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	EIF2B1(1), EIF2B2(3), EIF2B3(2), EIF2B5(1), ELAVL1(1), FLT1(4), FLT4(11), HIF1A(1), HRAS(1), KDR(1), NOS3(9), PIK3R1(2), PLCG1(1), PTK2(3), PXN(1), SHC1(2)	8940529	44	20	44	12	14	11	10	1	8	0	0.207	1.000	1.000
400	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), AOX1(2), DBH(1), DCT(3), DDC(1), FAH(1), GOT1(3), HGD(2), HPD(3), TAT(1), TH(1), TPO(7), TYR(4)	8864271	55	20	55	19	23	8	10	6	7	1	0.257	1.000	1.000
401	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DGAT1(3), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), GLB1(2), LCT(6), LIPF(2), LIPG(4), LPL(4), PNLIP(2), PPAP2B(2), PPAP2C(1)	13296369	76	27	76	24	33	11	8	8	16	0	0.118	1.000	1.000
402	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(1), ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1D1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), BAAT(1), CYP27A1(3), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(3), SOAT1(1)	8576630	43	13	43	12	16	9	9	5	4	0	0.153	1.000	1.000
403	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHB(1), PDHA1(4), PDHA2(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PGM1(1), PKLR(2), TPI1(3)	13586408	73	26	71	18	35	18	8	5	7	0	0.0113	1.000	1.000
404	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHB(1), PDHA1(4), PDHA2(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PGM1(1), PKLR(2), TPI1(3)	13586408	73	26	71	18	35	18	8	5	7	0	0.0113	1.000	1.000
405	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(3), CHUK(1), ELK1(2), IKBKB(4), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAPK8(2), NFKBIA(2), PPARA(1), RELA(3), TLR10(1), TLR2(2), TLR3(3), TLR4(1), TLR6(4), TLR9(5), TRAF6(1)	9901117	48	22	47	14	12	6	8	9	13	0	0.386	1.000	1.000
406	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	31	AGT(1), EGFR(2), ELK1(2), GNAQ(1), HRAS(1), MAP2K4(5), MAP3K1(3), MAPK8(2), MEF2A(2), MEF2C(2), MEF2D(2), PTK2(3), SHC1(2), SRC(2), SYT1(1)	8330096	31	12	31	10	5	6	6	5	9	0	0.458	1.000	1.000
407	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(1), CAPN2(1), CAPNS1(3), CAPNS2(2), EGF(4), EGFR(2), HRAS(1), ITGA1(7), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTK2(3), PXN(1), TLN1(11)	9220196	60	19	60	12	24	16	8	7	5	0	0.00524	1.000	1.000
408	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNGR1(2), JAK1(1), JAK2(2), PTPRU(6), REG1A(2), STAT1(3)	3185640	17	9	16	9	8	0	5	2	2	0	0.889	1.000	1.000
409	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	CASP2(3), CASP8(2), CRADD(2), DFFB(1), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(5), MAP3K1(3), MAPK8(2), PAK2(3), PRKDC(9), RB1(3), SPTAN1(3), TNFRSF1A(2), TRADD(1), TRAF2(1)	10399527	45	14	45	10	12	3	11	8	11	0	0.227	1.000	1.000
410	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(3), AKT2(2), AKT3(4), BCR(2), BTK(1), CD19(1), DAPP1(2), FLOT2(1), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), PDK1(1), PHF11(1), PLCG2(7), PPP1R13B(1), PREX1(9), PTEN(2), PTPRC(3), RPS6KA1(2), RPS6KA2(2), SAG(1), SYK(2), TEC(2), VAV1(6)	14801447	88	40	80	23	31	8	9	15	24	1	0.189	1.000	1.000
411	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2RL3(1), GNAI1(1), GNB1(2), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(2), PTK2(3), SRC(2), SYK(2), TBXAS1(1)	6806211	23	4	23	9	7	8	2	4	2	0	0.640	1.000	1.000
412	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ABAT(2), ACAA1(1), ACADM(2), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), AUH(1), BCAT1(2), BCAT2(2), BCKDHA(4), BCKDHB(2), DBT(3), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HMGCS2(1), HSD17B4(3), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2), OXCT2(1)	11794249	53	21	51	10	17	10	10	5	11	0	0.0258	1.000	1.000
413	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	39	ALAS2(3), BLVRA(2), COX15(1), CP(5), CPOX(3), EARS2(1), EPRS(1), FTMT(3), GUSB(1), HMBS(1), PPOX(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	11285707	48	23	44	11	8	12	6	10	12	0	0.225	1.000	1.000
414	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(4), AGPAT1(1), AGPAT3(3), AGPAT4(3), CDIPT(3), CHAT(4), CPT1B(5), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), GNPAT(1), GPD1(1), GPD2(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(2), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLCB2(5), PLCG1(1), PLCG2(7), PPAP2B(2), PPAP2C(1)	14194517	75	28	75	21	23	10	15	11	16	0	0.162	1.000	1.000
415	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	19	GNAQ(1), GNB1(2), HRAS(1), LIMK1(1), NOX1(4), PLCB1(1), PPP1R12B(1), PTK2(3), ROCK2(2)	6261415	16	6	16	9	5	5	1	2	3	0	0.882	1.000	1.000
416	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(4), AR(4), ESR1(1), ESR2(3), ESRRA(2), NPM1(1), NR0B1(3), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(3), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), PGR(4), PPARA(1), PPARD(2), PPARG(1), RARB(2), RARG(2), ROR1(4), RORA(1), RORC(1), RXRA(1), RXRB(1), RXRG(1), THRB(1)	11672631	63	25	60	19	17	15	10	6	15	0	0.149	1.000	1.000
417	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(1), ELK1(2), FCER1A(1), FCER1G(1), HRAS(1), LYN(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PAK2(3), PIK3R1(2), PLCG1(1), PPP3CA(3), PPP3CC(2), SHC1(2), SYK(2), SYT1(1), VAV1(6)	10655616	63	24	59	16	17	12	6	10	17	1	0.163	1.000	1.000
418	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1A1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DGAT1(3), DGAT2(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), GK2(5), GLB1(2), GPAM(4), LCT(6), LIPA(1), LIPF(2), LIPG(4), LPL(4), MGLL(2), PNLIP(2), PPAP2B(2), PPAP2C(1)	16220556	95	33	95	28	36	17	12	11	19	0	0.0592	1.000	1.000
419	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLB(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLG(5), POLH(1), POLI(1), POLK(3), POLL(2), POLM(2), POLQ(3), PRIM1(1), REV1(1), REV3L(6)	11450899	42	14	40	7	8	8	9	8	9	0	0.102	1.000	1.000
420	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(3), AKT2(2), AKT3(4), ASAH1(1), BRAF(4), DAG1(2), EGFR(2), EPHB2(4), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), PIK3CB(3), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), SHC1(2), SOS2(1), SRC(2), STAT3(2), TERF2IP(1)	15703704	81	41	74	20	23	8	11	11	28	0	0.280	1.000	1.000
421	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), PDE6B(3), PDE6C(1), PDE6G(1), SLC6A13(1)	9225920	44	20	39	13	14	5	9	3	13	0	0.511	1.000	1.000
422	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(8), AR(4), ASAH1(1), BRAF(4), CAMP(2), CCL16(1), DAG1(2), EGFR(2), GNA11(3), GNA15(4), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), MAPK10(1), PHKA2(7), PIK3CD(2), PIK3R1(2), SRC(2)	14474328	86	43	77	20	24	11	14	10	27	0	0.128	1.000	1.000
423	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CAMK1(2), CAMK1G(1), ELK1(2), FPR1(2), GNA15(4), GNB1(2), HRAS(1), MAP2K3(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKBIA(2), PLCB1(1), PPP3CA(3), PPP3CC(2), RELA(3), SYT1(1)	10485627	55	23	51	17	15	12	10	6	12	0	0.369	1.000	1.000
424	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(1), IKBKB(4), IL1B(1), IL1RAP(2), IL1RN(2), IL6(1), IRAK3(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), MAPK8(2), NFKBIA(2), RELA(3), TGFB1(1), TGFB2(2), TRAF6(1)	8000664	31	14	30	10	5	5	6	5	10	0	0.604	1.000	1.000
425	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(1), PTPRU(6), REG1A(2), STAT1(3), STAT2(2), TYK2(2)	3485751	18	9	17	9	10	0	5	2	1	0	0.818	1.000	1.000
426	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(4), AGT(1), AKT1(3), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(3), CSNK1A1(1), ELSPBP1(2), FKBP1A(1), GATA4(1), GSK3B(2), HAND2(1), HRAS(1), LIF(2), MAPK8(2), MEF2C(2), MYH2(4), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NKX2-5(1), PIK3R1(2), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1)	13489785	74	31	69	19	29	13	12	8	12	0	0.0588	1.000	1.000
427	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(2), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHAL6B(2), LDHB(1), PDHA1(4), PDHA2(2), PFKL(2), PFKM(3), PFKP(1), PGAM1(1), PGAM4(2), PGK1(3), PGM1(1), PKLR(2), TPI1(3)	16213255	86	31	84	23	39	22	10	5	10	0	0.0172	1.000	1.000
428	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(4), CRK(1), CRKL(2), DOCK1(5), ELK1(2), HGF(1), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PIK3R1(2), PTEN(2), PTK2(3), PXN(1), RAP1B(3), RASA1(4), SRC(2), STAT3(2)	10876070	51	20	51	16	13	16	4	6	12	0	0.279	1.000	1.000
429	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(1), ELK1(2), HRAS(1), LYN(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), SHC1(2), SYK(2), SYT1(1), VAV1(6)	9933012	49	19	45	14	13	10	3	8	14	1	0.289	1.000	1.000
430	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(3), CDC42(1), DUSP10(1), DUSP8(1), GCK(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K9(4), MAPK10(1), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(2), TRAF6(1), ZAK(5)	13609306	62	29	58	17	18	8	11	8	17	0	0.396	1.000	1.000
431	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(1), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GNT2(2), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALNT1(1), FUT1(1), FUT2(3), FUT3(1), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GBGT1(1), GCNT2(1), PIGB(3), PIGG(2), PIGL(2), PIGM(1), PIGO(9), PIGP(2), PIGQ(6), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(2), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3), UGCG(1)	13358685	72	33	69	12	26	13	14	7	12	0	0.00151	1.000	1.000
432	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	32	ABAT(2), ACACA(4), ACACB(8), ACADM(2), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), LDHAL6B(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3)	10793970	40	15	40	10	14	8	6	5	7	0	0.192	1.000	1.000
433	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(3), APC(8), ASAH1(1), CAMP(2), DAG1(2), DLG4(3), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), RYR1(24)	12948450	82	39	76	24	32	7	14	9	20	0	0.245	1.000	1.000
434	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADL(2), ACADM(2), ACADS(1), ACADSB(3), ACAT1(2), ACOX1(1), ACOX3(2), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP4A22(2), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3)	13608163	69	21	69	14	25	17	9	7	11	0	0.00705	1.000	1.000
435	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	38	ACTG2(3), ADCY3(7), ADCY9(5), ARF1(2), ARF3(1), ARF4(1), ARL4D(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0C(1), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), ERO1L(1), PDIA4(2), PLCG1(1), PLCG2(7), SEC61A1(1), SEC61A2(2), SEC61B(1), SEC61G(1), TRIM23(1)	8882279	48	18	48	16	16	10	8	5	9	0	0.343	1.000	1.000
436	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	29	GTF2A1(1), GTF2E1(1), GTF2H1(1), GTF2H4(1), GTF2IRD1(2), STON1(2), TAF1(10), TAF1L(7), TAF2(2), TAF4(4), TAF4B(2), TAF5(1), TAF5L(4), TAF6(2), TAF6L(3), TAF7L(1), TAF9(2)	9218858	46	26	40	14	9	5	9	6	17	0	0.863	1.000	1.000
437	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	64	ACAA1(1), ACADL(2), ACADM(2), ACOX1(1), ACOX2(2), ACOX3(2), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ANGPTL4(1), APOA5(3), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP27A1(3), CYP4A22(2), CYP7A1(2), CYP8B1(2), EHHADH(1), FABP4(1), GK2(5), HMGCS2(1), ILK(1), LPL(4), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(5), PLTP(1), PPARA(1), PPARD(2), PPARG(1), RXRA(1), RXRB(1), RXRG(1), SCP2(1), SLC27A1(3), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(2), SORBS1(1), UBC(2), UCP1(1)	17596316	96	37	94	27	30	22	18	8	16	2	0.0759	1.000	1.000
438	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	38	ALG10(1), ALG10B(2), ALG11(3), ALG12(4), ALG13(2), ALG5(1), ALG9(1), DDOST(1), DHDDS(1), DOLPP1(1), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT3(3), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1)	11274179	40	16	39	12	13	10	5	7	5	0	0.289	1.000	1.000
439	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	67	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1C1(1), AKR1C3(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), CYP1A1(2), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2F1(3), CYP2S1(2), CYP3A5(1), CYP3A7(3), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	15351285	87	28	82	26	23	19	17	13	15	0	0.196	1.000	1.000
440	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	76	AIFM1(2), AKT1(3), AKT2(2), AKT3(4), APAF1(3), ATM(11), BAD(1), BIRC2(2), CAPN1(1), CAPN2(1), CASP10(2), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CSF2RB(2), DFFB(1), FASLG(1), IKBKB(4), IL1B(1), IL1RAP(2), IL3RA(3), IRAK3(2), IRAK4(1), NFKB2(1), NFKBIA(2), NTRK1(3), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RELA(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	21986010	105	46	103	25	38	20	13	14	20	0	0.0272	1.000	1.000
441	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), FUK(1), GMDS(1), GMPPA(5), HK1(3), HK2(3), HK3(4), HSD3B7(3), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(3), PFKL(2), PFKM(3), PFKP(1), PGM2(1), PHPT1(1), PMM2(2), RDH11(2), TPI1(3), TSTA3(1)	10476671	51	21	51	17	22	8	14	5	2	0	0.256	1.000	1.000
442	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(4), ACTN1(1), ACTN2(4), BCAR1(2), BCR(2), CAPN1(1), CAPNS1(3), CAPNS2(2), CRKL(2), CSK(1), HRAS(1), ITGA1(7), MAPK8(2), PPP1R12B(1), PTK2(3), PXN(1), ROCK1(6), SHC1(2), SRC(2), TLN1(11), VCL(3), ZYX(1)	12288296	62	24	62	12	22	18	6	6	10	0	0.00690	1.000	1.000
443	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	BCR(2), BLNK(1), ELK1(2), HRAS(1), LYN(1), MAP3K1(3), MAPK8IP3(5), PAPPA(3), RPS6KA1(2), SHC1(2), SYK(2), VAV1(6)	8296399	30	15	29	11	10	3	4	4	8	1	0.614	1.000	1.000
444	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(1), CITED2(1), CPT1B(5), CREBBP(3), DUT(1), EHHADH(1), EP300(6), HSD17B4(3), HSPA1A(1), LPL(4), ME1(2), MYC(2), NCOR1(9), NCOR2(5), NFKBIA(2), NR1H3(3), NR2F1(2), NRIP1(1), PIK3R1(2), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTGS2(1), RB1(3), RELA(3), RXRA(1), SP1(1), STAT5A(2)	17166185	75	30	75	22	25	16	13	8	13	0	0.149	1.000	1.000
445	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	62	APAF1(3), BAD(1), BAK1(1), BIRC2(2), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FASLG(1), HELLS(1), IKBKB(4), IRF1(2), IRF2(1), IRF3(1), IRF5(1), IRF6(4), IRF7(2), MAP2K4(5), MAP3K1(3), MAPK10(1), MDM2(2), MYC(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), RELA(3), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TP73(1), TRADD(1), TRAF2(1)	15409578	71	30	70	20	16	12	16	9	17	1	0.316	1.000	1.000
446	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	57	ATP12A(8), ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), ATP7A(4), ATP7B(1), COX4I1(1), COX6A1(1), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV2(3), SDHA(6), SHMT1(2), UQCRB(1), UQCRFS1(1), UQCRH(2)	9570060	51	24	48	17	12	11	8	12	7	1	0.538	1.000	1.000
447	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	61	ADAM10(1), ADAM17(4), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), IGSF5(1), IKBKB(4), JAM2(2), LYN(1), MAP2K4(5), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NOD1(3), PLCG1(1), PLCG2(7), PTPRZ1(4), RELA(3), SRC(2), TCIRG1(1), TJP1(6)	18130218	79	27	79	18	14	19	18	13	15	0	0.0566	1.000	1.000
448	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(3), ATF1(1), CDC42(1), CREB1(2), CREB5(1), DUSP10(1), ELK1(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K10(4), MAP3K4(2), MAP3K5(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), MKNK2(3), MYEF2(2), NR2C2(1), SRF(1), TRAF6(1)	9157579	40	25	39	14	8	5	9	4	14	0	0.684	1.000	1.000
449	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), AOX1(2), CARM1(2), DBH(1), DCT(3), DDC(1), ESCO1(3), FAH(1), GOT1(3), HEMK1(1), HGD(2), HPD(3), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), SH3GLB1(1), TAT(1), TH(1), TPO(7), TYR(4), TYRP1(1)	16041052	77	23	77	22	26	15	18	9	8	1	0.103	1.000	1.000
450	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	CDC42(1), CREB1(2), DAXX(6), ELK1(2), HRAS(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K5(2), MAP3K9(4), MAPKAPK5(1), MAX(1), MEF2A(2), MEF2C(2), MEF2D(2), MYC(2), RPS6KA5(4), SHC1(2), STAT1(3), TGFB1(1), TGFB2(2), TRADD(1), TRAF2(1)	9723575	53	27	49	18	12	5	10	6	20	0	0.796	1.000	1.000
451	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AANAT(1), ACAT1(2), AFMID(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), AOX1(2), ASMT(2), CARM1(2), CAT(1), CYP1A1(2), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), INMT(1), KMO(2), KYNU(1), LCMT1(1), LCMT2(2), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(5), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), TDO2(1), TPH1(2), TPH2(2), WARS(2)	16677010	74	23	74	19	25	12	21	8	8	0	0.0788	1.000	1.000
452	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	43	AKT1(3), AKT2(2), AKT3(4), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(2), CSK(1), DAG1(2), FLOT2(1), GSK3A(2), GSK3B(2), INPP5D(1), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), MAP4K1(3), NFATC1(4), NFATC2(10), PDK1(1), PIK3CD(2), PIK3R1(2), PLCG2(7), PPP1R13B(1), PPP3CA(3), PPP3CC(2), PTPRC(3), SHC1(2), SOS2(1), SYK(2), VAV1(6)	18800097	110	45	98	24	38	16	11	13	31	1	0.0165	1.000	1.000
453	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), AOX1(2), ASMT(2), CAT(1), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2D6(1), CYP2E1(3), CYP2F1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), CYP4B1(1), CYP51A1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2)	15316734	76	30	74	23	27	10	20	10	9	0	0.235	1.000	1.000
454	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(3), CD14(3), CD19(1), CD1A(2), CD1B(5), CD1C(2), CD1E(1), CD2(2), CD22(2), CD33(3), CD34(1), CD38(2), CD3E(1), CD4(2), CD44(4), CD5(2), CD55(1), CD59(2), CD8B(2), CR1(5), CSF1(2), CSF1R(5), CSF2RA(1), CSF3(2), CSF3R(3), DNTT(4), EPO(2), EPOR(2), FCGR1A(1), FLT3(4), FLT3LG(1), GP5(2), GP9(2), HLA-DRB1(1), IL1B(1), IL2RA(1), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL7(1), IL7R(3), IL9R(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGAM(1), ITGB3(1), KIT(4), MME(2), MS4A1(4), THPO(1), TPO(7)	21798433	130	53	123	33	30	19	26	25	30	0	0.0698	1.000	1.000
455	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(4), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(3), CHAT(4), CHPT1(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), ESCO1(3), ETNK2(2), GNPAT(1), GPAM(4), GPD1(1), GPD2(1), LYPLA2(1), PCYT1A(2), PCYT1B(1), PHOSPHO1(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLD2(5), PPAP2B(2), PPAP2C(1), PTDSS1(3), PTDSS2(1), SH3GLB1(1)	18250837	82	36	80	25	24	12	15	13	18	0	0.224	1.000	1.000
456	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	AK3(1), CAD(6), CTPS2(1), DCK(1), DPYD(4), DTYMK(1), DUT(1), ITPA(1), NME1(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3), RRM1(2), TYMS(1), UMPS(2), UPB1(2)	15726936	67	23	67	20	24	16	11	9	7	0	0.109	1.000	1.000
457	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	66	ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(2), ACVR1C(2), BAIAP2(4), CDC42(1), CDH1(1), CREBBP(3), CSNK2A1(1), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTNND1(3), EGFR(2), EP300(6), ERBB2(6), FARP2(3), FER(6), FGFR1(1), IGF1R(6), INSR(4), IQGAP1(3), LEF1(3), LMO7(7), MET(4), MLLT4(5), NLK(2), PARD3(7), PTPN6(4), PTPRB(10), PTPRJ(3), PTPRM(6), PVRL2(1), PVRL3(1), RAC2(1), RHOA(1), SMAD2(1), SMAD3(1), SORBS1(1), SRC(2), SSX2IP(2), TCF7(2), TCF7L1(4), TCF7L2(1), TJP1(6), VCL(3), WASF1(1), WASF2(2), WASL(6), YES1(1)	29939071	174	60	166	30	47	33	29	28	36	1	0.000237	1.000	1.000
458	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	29	AKT1(3), ANGPTL2(2), DAG1(2), DGKA(2), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NR1I3(1), PDE3B(1), PIK3CD(2), PIK3R1(2), RIPK3(2), SGCB(1)	12236331	53	25	47	18	15	5	10	4	19	0	0.730	1.000	1.000
459	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	184	ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(4), ARHGAP5(6), BAD(1), BCAR1(2), BIRC2(2), BRAF(4), CAPN2(1), CCND2(3), CCND3(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(5), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A6(6), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), COMP(4), CRK(1), CRKL(2), CTNNB1(9), DIAPH1(7), DOCK1(5), EGF(4), EGFR(2), ELK1(2), ERBB2(6), FARP2(3), FLNA(10), FLNB(4), FLNC(12), FLT1(4), FN1(9), GSK3B(2), HGF(1), HRAS(1), IBSP(3), IGF1R(6), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), KDR(1), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), MAPK10(1), MAPK8(2), MAPK9(1), MET(4), MYL9(1), MYLK(11), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PARVB(3), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(7), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTEN(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RELN(14), RHOA(1), ROCK1(6), ROCK2(2), SHC1(2), SHC2(2), SHC4(2), SOS2(1), SRC(2), THBS1(7), THBS2(4), THBS3(1), TLN1(11), TLN2(6), TNC(14), TNN(5), TNR(14), TNXB(13), VAV1(6), VCL(3), VEGFC(1), VTN(2), VWF(5), ZYX(1)	99632225	550	137	529	162	165	114	87	79	100	5	0.00385	1.000	1.000
460	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	232	ACVR1B(2), ACVR1C(2), AKT1(3), AKT2(2), AKT3(4), ARRB1(1), ARRB2(3), ATF4(1), BDNF(1), BRAF(4), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1E(10), CACNA1F(2), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(6), CACNA2D2(2), CACNA2D3(3), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(3), CACNG3(3), CACNG4(1), CACNG5(2), CD14(3), CDC25B(2), CDC42(1), CHUK(1), CRK(1), CRKL(2), DAXX(6), DUSP10(1), DUSP14(1), DUSP16(2), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(1), EGF(4), EGFR(2), ELK1(2), ELK4(1), FASLG(1), FGF12(1), FGF13(2), FGF14(2), FGF17(1), FGF18(1), FGF23(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(4), FLNA(10), FLNB(4), FLNC(12), HRAS(1), IKBKB(4), IL1B(1), JUND(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(3), MAX(1), MEF2C(2), MKNK2(3), MOS(3), MRAS(2), MYC(2), NF1(6), NFATC2(10), NFATC4(5), NFKB2(1), NLK(2), NR4A1(3), NTRK1(3), NTRK2(3), PAK2(3), PDGFRA(3), PDGFRB(7), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), PTPN5(1), RAC2(1), RAP1B(3), RAPGEF2(6), RASA1(4), RASA2(2), RASGRF1(1), RASGRP1(2), RASGRP2(1), RASGRP3(2), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS(2), SOS2(1), SRF(1), STK3(1), STK4(3), STMN1(1), TAOK1(4), TGFB1(1), TGFB2(2), TNFRSF1A(2), TRAF2(1), TRAF6(1), ZAK(5)	76204957	415	125	395	130	138	63	65	51	94	4	0.0829	1.000	1.000
461	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	132	ACTB(2), CHAD(1), COL11A1(7), COL11A2(5), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A6(6), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), COMP(4), DES(1), DSC1(5), DSC2(6), DSC3(6), DSG1(2), DSG2(3), DSG3(1), DSG4(5), FN1(9), GJA1(1), GJA10(1), GJA3(1), GJA4(2), GJA5(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJC3(2), GJD4(2), IBSP(3), INA(3), ITGA6(5), ITGB4(8), KRT1(2), KRT10(2), KRT12(3), KRT13(2), KRT14(2), KRT15(4), KRT16(1), KRT17(3), KRT19(1), KRT2(3), KRT20(3), KRT24(2), KRT25(1), KRT27(1), KRT28(2), KRT3(2), KRT31(2), KRT33A(2), KRT33B(1), KRT34(3), KRT37(1), KRT38(2), KRT39(2), KRT4(2), KRT40(1), KRT5(1), KRT6A(4), KRT6B(1), KRT7(3), KRT72(1), KRT74(3), KRT75(1), KRT77(2), KRT78(2), KRT79(2), KRT82(2), KRT83(4), KRT85(1), KRT86(2), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), LMNB1(1), LMNB2(1), NES(7), PRPH(1), RELN(14), THBS1(7), THBS2(4), THBS3(1), TNC(14), TNN(5), TNR(14), TNXB(13), VTN(2), VWF(5)	67137030	416	122	398	133	135	72	76	57	73	3	0.0738	1.000	1.000
462	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	159	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY7(2), ADCY8(4), ADCY9(5), ADORA2A(1), ADRA1A(4), ADRA1D(1), ADRB2(1), ATP2A1(6), ATP2A2(3), ATP2B1(7), ATP2B2(7), ATP2B4(2), AVPR1A(1), AVPR1B(1), BDKRB1(1), BDKRB2(1), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1E(10), CACNA1F(2), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(6), CALML3(1), CALML6(2), CAMK2D(1), CAMK4(2), CCKBR(3), CD38(2), CHRM1(1), CHRM2(3), CHRM3(2), CHRM5(3), CHRNA7(1), CYSLTR2(1), DRD1(5), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(6), ERBB4(6), GNA11(3), GNA14(1), GNA15(4), GNAL(3), GNAQ(1), GRIN2A(7), GRIN2C(6), GRIN2D(5), GRM5(7), GRPR(1), HRH2(2), HTR2A(3), HTR2B(1), HTR4(1), HTR5A(5), HTR7(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), LHCGR(2), LTB4R2(1), MYLK(11), MYLK2(4), NOS1(10), NOS3(9), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(2), PDE1B(2), PDE1C(1), PDGFRA(3), PDGFRB(7), PHKA2(7), PHKB(4), PHKG1(2), PHKG2(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PPID(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), PTGER3(1), PTGFR(2), RYR1(24), RYR3(23), SLC25A4(1), SLC25A5(1), SLC25A6(3), SLC8A1(2), SLC8A2(4), SLC8A3(5), SPHK1(1), SPHK2(1), TACR1(3), TACR2(1), TACR3(4), TBXA2R(1), TNNC1(2), TNNC2(1), TRHR(2), TRPC1(3), VDAC2(1)	69976639	467	122	451	147	185	67	92	60	60	3	0.00266	1.000	1.000
463	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	81	AGRN(2), CD44(4), CHAD(1), COL11A1(7), COL11A2(5), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A6(6), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), DAG1(2), FN1(9), FNDC1(9), FNDC3A(3), GP5(2), GP6(1), GP9(2), HSPG2(3), IBSP(3), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), RELN(14), SDC3(1), SDC4(2), SV2A(5), SV2C(1), THBS1(7), THBS2(4), THBS3(1), TNC(14), TNN(5), TNR(14), TNXB(13), VTN(2), VWF(5)	60573678	340	104	324	103	94	69	65	47	62	3	0.0594	1.000	1.000
464	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	227	ADORA2A(1), ADORA3(5), ADRA1A(4), ADRA2A(1), ADRA2B(4), ADRA2C(3), ADRB2(1), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), C5AR1(1), CALCR(2), CCKBR(3), CGA(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CRHR1(2), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(5), DRD3(1), DRD5(5), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHB(1), FSHR(4), GABBR2(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GABRB1(3), GABRB2(2), GABRB3(5), GABRE(3), GABRG1(1), GABRG2(1), GABRG3(2), GABRP(1), GABRQ(2), GABRR2(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GIPR(2), GLP2R(3), GLRA1(3), GLRA2(3), GLRB(1), GNRHR(1), GPR156(2), GPR35(1), GPR50(2), GPR83(1), GRIA1(3), GRIA2(1), GRIA4(2), GRID1(7), GRID2(10), GRIK1(1), GRIK2(9), GRIK3(4), GRIK4(2), GRIK5(2), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRIN3A(4), GRIN3B(5), GRM2(5), GRM3(3), GRM4(4), GRM5(7), GRM6(7), GRM7(5), GRM8(5), GRPR(1), HCRTR1(2), HRH2(2), HRH3(1), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR4(1), HTR5A(5), HTR7(1), LEPR(7), LHB(2), LHCGR(2), LTB4R2(1), MC2R(2), MC3R(4), MC5R(3), MCHR1(3), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(3), NMBR(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR1(1), NPFFR2(1), NPY1R(3), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(7), PRL(4), PRLR(2), PRSS3(1), PTGDR(2), PTGER3(1), PTGFR(2), RXFP1(1), SSTR1(4), SSTR3(2), SSTR4(3), SSTR5(5), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(2), TAAR8(3), TACR1(3), TACR2(1), TACR3(4), TBXA2R(1), THRB(1), TRHR(2), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1)	59211677	408	103	397	133	150	69	85	58	45	1	0.00277	1.000	1.000
465	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	117	ABL1(7), ABLIM1(6), ABLIM2(2), ABLIM3(2), ARHGEF12(6), CDC42(1), CXCR4(3), DCC(4), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNB2(1), EPHA1(4), EPHA2(5), EPHA3(2), EPHA4(4), EPHA5(7), EPHA6(2), EPHA7(3), EPHA8(8), EPHB1(2), EPHB2(4), EPHB3(4), EPHB4(5), GNAI1(1), GNAI2(1), GSK3B(2), HRAS(1), L1CAM(6), LIMK1(1), LIMK2(2), LRRC4C(3), MET(4), NCK1(3), NCK2(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NRP1(1), NTN4(1), NTNG1(3), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(9), PLXNA3(8), PLXNB1(6), PLXNB2(6), PLXNB3(6), PLXNC1(4), PPP3CA(3), PPP3CC(2), PTK2(3), RAC2(1), RASA1(4), RGS3(2), RHOA(1), RHOD(1), RND1(2), ROBO1(8), ROBO2(7), ROBO3(11), ROCK1(6), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(5), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(1), SEMA4C(5), SEMA4F(3), SEMA4G(3), SEMA5A(6), SEMA5B(4), SEMA6A(2), SEMA6C(3), SEMA6D(1), SEMA7A(1), SLIT1(8), SLIT2(7), SLIT3(7), SRGAP1(9), SRGAP2(1), UNC5B(3), UNC5C(3)	51575949	325	103	312	112	111	57	47	47	62	1	0.238	1.000	1.000
466	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	192	ABI2(2), ACTN1(1), ACTN2(4), ACTN4(1), APC(8), APC2(2), ARAF(2), ARHGEF1(3), ARHGEF12(6), ARHGEF6(2), ARPC1A(2), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(4), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(4), CD14(3), CDC42(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CRK(1), CRKL(2), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH1(7), DIAPH2(1), DOCK1(5), EGF(4), EGFR(2), FGD1(1), FGF12(1), FGF13(2), FGF14(2), FGF17(1), FGF18(1), FGF23(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(4), FN1(9), HRAS(1), IQGAP1(3), IQGAP2(1), IQGAP3(3), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(7), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), LIMK1(1), LIMK2(2), MOS(3), MRAS(2), MYH14(7), MYH9(4), MYL9(1), MYLK(11), MYLK2(4), NCKAP1(4), NCKAP1L(5), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(7), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PPP1R12B(1), PTK2(3), PXN(1), RAC2(1), RDX(4), RHOA(1), ROCK1(6), ROCK2(2), RRAS(2), SCIN(1), SOS2(1), SSH1(4), SSH2(3), SSH3(1), TIAM1(10), TIAM2(5), VAV1(6), VCL(3), WASF1(1), WASF2(2), WASL(6)	72960312	346	101	336	118	105	63	60	42	74	2	0.347	1.000	1.000
467	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	132	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADRA1A(4), ADRA1D(1), ADRB2(1), ANXA6(3), ARRB1(1), ARRB2(3), ATP1A4(4), ATP1B3(1), ATP2A2(3), ATP2B1(7), ATP2B2(7), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1E(10), CACNA1S(6), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), GJA1(1), GJA4(2), GJA5(1), GJB1(1), GJB4(1), GJB6(2), GNA11(3), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK4(2), GRK5(4), GRK6(1), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), MIB1(3), NME7(1), PLCB3(4), PRKACB(1), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCQ(3), PRKD1(1), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(2), RGS7(2), RYR1(24), RYR3(23), SLC8A1(2), SLC8A3(5), USP5(2), YWHAH(1)	47281845	284	96	273	108	111	52	49	29	40	3	0.204	1.000	1.000
468	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	140	APC(8), APC2(2), AXIN1(4), AXIN2(1), BTRC(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(10), CREBBP(3), CSNK1A1(1), CSNK1A1L(4), CSNK1E(1), CSNK2A1(1), CTBP2(3), CTNNB1(9), CUL1(4), CXXC4(1), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(4), DVL3(2), EP300(6), FBXW11(2), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GSK3B(2), LEF1(3), LRP5(7), LRP6(5), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(2), MYC(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NKD1(4), NKD2(1), NLK(2), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPARD(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP3CA(3), PPP3CC(2), PRICKLE1(3), PRICKLE2(4), PRKACB(1), PRKACG(3), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(6), ROCK2(2), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD2(1), SMAD3(1), SOX17(1), TCF7(2), TCF7L1(4), TCF7L2(1), VANGL1(2), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1)	43562374	259	94	250	84	89	51	33	41	45	0	0.0773	1.000	1.000
469	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	134	ACTA1(4), ACTA2(2), ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADM(1), ARRB1(1), ARRB2(3), ATF1(1), ATF3(1), ATF4(1), ATF5(1), ATP2A2(3), CALCA(2), CAMK2D(1), CNN2(1), CORIN(3), CRHR1(2), DGKZ(3), ETS2(2), GABPA(2), GABPB2(1), GBA2(3), GJA1(1), GNAQ(1), GNB1(2), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK4(2), GRK5(4), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(2), IL1B(1), IL6(1), ITPR1(10), ITPR2(12), ITPR3(10), MAFF(2), MIB1(3), MYLK2(4), NOS1(10), NOS3(9), OXTR(2), PDE4D(2), PLCB3(4), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCE(1), PRKCQ(3), PRKD1(1), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(2), RGS7(2), RYR1(24), RYR3(23), SLC8A1(2), SP1(1), TNXB(13), USP5(2), YWHAH(1)	45446754	258	91	249	99	98	41	43	30	44	2	0.398	1.000	1.000
470	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	242	ACVR1B(2), AMH(2), AMHR2(5), BMP2(3), BMP7(2), BMPR1A(4), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(2), CCL26(1), CCL27(1), CCL3(1), CCL7(1), CCL8(1), CCR1(2), CCR2(1), CCR4(4), CCR7(1), CCR9(1), CD40(1), CRLF2(1), CSF1(2), CSF1R(5), CSF2RA(1), CSF2RB(2), CSF3(2), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCR4(3), EDA(1), EDA2R(2), EDAR(2), EGF(4), EGFR(2), EPO(2), EPOR(2), FASLG(1), FLT1(4), FLT3(4), FLT3LG(1), FLT4(11), GDF5(2), GHR(1), HGF(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL17RA(3), IL18R1(1), IL18RAP(3), IL1B(1), IL1RAP(2), IL20RA(2), IL21(2), IL21R(1), IL22RA1(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL6ST(4), IL7(1), IL7R(3), IL9(1), IL9R(1), INHBA(2), INHBB(2), INHBC(1), KDR(1), KIT(4), LEPR(7), LIF(2), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(3), PDGFC(2), PDGFRA(3), PDGFRB(7), PF4V1(1), PLEKHO2(1), PRL(4), PRLR(2), RELT(1), TGFB1(1), TGFB2(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(5), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF8(2), TNFSF12(2), TNFSF13(2), TNFSF14(1), TNFSF18(1), TNFSF8(3), TPO(7), TSLP(1), VEGFC(1), XCR1(3)	47918407	264	88	255	68	77	53	41	40	53	0	0.00263	1.000	1.000
471	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(4), AMOTL1(2), ASH1L(9), CDC42(1), CDK4(2), CGN(1), CLDN17(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTTN(2), EPB41(4), EPB41L1(3), EPB41L2(3), EPB41L3(4), EXOC3(1), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), IGSF5(1), INADL(1), JAM2(2), LLGL1(5), LLGL2(3), MAGI1(2), MAGI2(12), MAGI3(2), MLLT4(5), MPDZ(4), MRAS(2), MYH1(6), MYH11(8), MYH13(4), MYH14(7), MYH15(10), MYH2(4), MYH3(2), MYH4(10), MYH6(7), MYH7(8), MYH7B(8), MYH8(6), MYH9(4), MYL9(1), PARD3(7), PARD6A(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP2R3A(4), PPP2R3B(2), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(3), PTEN(2), RAB13(1), RHOA(1), RRAS(2), SPTAN1(3), SRC(2), SYMPK(5), TJP1(6), TJP2(5), TJP3(3), YES1(1), ZAK(5)	52116323	280	88	271	83	88	48	46	42	56	0	0.0655	1.000	1.000
472	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(2), BRAF(4), CACNA1A(9), CRHR1(2), GNA11(3), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GRIA1(3), GRIA2(1), GRID2(10), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HRAS(1), IGF1R(6), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), NOS1(10), NOS3(9), NPR1(5), NPR2(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PRKCG(2), PRKG1(1), PRKG2(2), RYR1(24)	29752342	185	77	177	48	74	16	38	25	32	0	0.0433	1.000	1.000
473	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	124	ACACA(4), ACACB(8), AKT1(3), AKT2(2), AKT3(4), ARAF(2), BAD(1), BRAF(4), CALML3(1), CALML6(2), CBL(5), CBLB(2), CBLC(1), CRK(1), CRKL(2), ELK1(2), EXOC7(1), FASN(7), FBP2(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(2), GYS1(3), GYS2(2), HRAS(1), IKBKB(4), INPP5D(1), INSR(4), IRS2(4), IRS4(4), LIPE(2), MAPK10(1), MAPK8(2), MAPK9(1), MKNK2(3), PCK1(3), PCK2(5), PDE3B(1), PFKL(2), PFKM(3), PFKP(1), PHKA2(7), PHKB(4), PHKG1(2), PHKG2(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(4), PPP1R3C(2), PPP1R3D(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAG3(4), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCI(3), PYGB(2), PYGL(2), PYGM(2), RPS6KB2(4), SHC1(2), SHC2(2), SHC4(2), SOCS4(3), SORBS1(1), SOS2(1), TRIP10(1), TSC1(1), TSC2(8)	41301526	198	76	190	75	66	41	23	20	46	2	0.370	1.000	1.000
474	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADSL(2), ADSS(3), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(4), AMPD2(2), AMPD3(4), APRT(1), ATIC(2), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GART(1), GMPR(3), GMPR2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IMPDH1(3), ITPA(1), NME1(1), NME4(1), NME7(1), NPR1(5), NPR2(1), NT5C1B(3), NT5E(1), NT5M(1), NUDT2(1), NUDT9(4), PAICS(2), PAPSS1(2), PAPSS2(4), PDE11A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4C(2), PDE4D(2), PDE5A(3), PDE6G(1), PDE7B(1), PDE8A(2), PDE8B(3), PDE9A(1), PFAS(7), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RRM1(2), RRM2B(1), XDH(5)	44348294	213	74	207	66	77	37	31	33	33	2	0.0975	1.000	1.000
475	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(2), ACTN2(4), ACTN4(1), DES(1), DMD(11), MYBPC1(4), MYBPC2(1), MYBPC3(3), MYH3(2), MYH6(7), MYH7(8), MYH8(6), MYL1(1), MYL3(3), MYL9(1), MYOM1(4), NEB(21), TMOD1(1), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(4), TNNT2(3), TNNT3(1), TPM1(1), TPM3(1), TTN(116)	38480061	214	74	211	64	59	46	48	26	33	2	0.294	1.000	1.000
476	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	ALCAM(1), CADM1(3), CADM3(3), CD2(2), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(2), CD6(1), CD80(1), CD8B(2), CDH1(1), CDH15(4), CDH2(5), CDH4(5), CDH5(2), CLDN17(1), CLDN3(2), CLDN9(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(8), ESAM(1), F11R(1), GLG1(2), HLA-A(7), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(3), ICAM1(2), ICAM3(2), ICOSLG(1), ITGA4(1), ITGA6(5), ITGA8(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGB2(1), ITGB8(3), JAM2(2), L1CAM(6), MPZL1(1), NCAM1(3), NCAM2(5), NEGR1(2), NEO1(3), NFASC(5), NLGN1(5), NLGN2(3), NLGN3(5), NRCAM(2), NRXN1(4), NRXN2(7), NRXN3(4), PDCD1(1), PTPRC(3), PTPRM(6), PVRL2(1), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELL(1), SELP(3), SIGLEC1(12), VCAN(10)	39550289	207	70	203	81	68	35	39	33	32	0	0.336	1.000	1.000
477	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	144	AKT1(3), AKT2(2), AKT3(4), CBL(5), CBLB(2), CBLC(1), CCND2(3), CCND3(1), CISH(1), CREBBP(3), CRLF2(1), CSF2RA(1), CSF2RB(2), CSF3(2), CSF3R(3), EP300(6), EPO(2), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL20RA(2), IL21(2), IL21R(1), IL22RA1(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL6ST(4), IL7(1), IL7R(3), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(7), LIF(2), LIFR(5), MYC(2), OSMR(3), PIAS1(2), PIAS2(3), PIAS3(2), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PRL(4), PRLR(2), PTPN6(4), SOCS4(3), SOCS5(4), SOCS7(1), SOS2(1), SPRED1(1), SPRED2(1), STAM(6), STAM2(1), STAT1(3), STAT2(2), STAT3(2), STAT4(1), STAT5A(2), STAT6(5), TPO(7), TSLP(1), TYK2(2)	38033623	193	70	187	67	61	30	31	31	40	0	0.461	1.000	1.000
478	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALML3(1), CALML6(2), CDIPT(3), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(1), INPP5E(2), INPPL1(5), ITPK1(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), OCRL(1), PI4KA(4), PI4KB(2), PIK3C2A(5), PIK3C2B(12), PIK3C3(2), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PRKCG(2), PTEN(2), SYNJ1(2), SYNJ2(3)	33906158	169	69	161	48	56	23	22	23	45	0	0.0718	1.000	1.000
479	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	75	AGL(5), ASCC3(5), ATP13A2(2), DDX18(1), DDX23(1), DDX4(6), DDX41(2), DDX47(5), DDX50(7), DDX51(1), DDX54(2), DDX55(1), DDX56(2), DHX58(4), ENPP3(3), EP400(8), ERCC2(2), G6PC2(1), GAA(2), GANC(1), GBA(4), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(3), HK2(3), HK3(4), IFIH1(7), MGAM(1), MOV10L1(6), NUDT8(1), PGM1(1), PYGB(2), PYGL(2), PYGM(2), RAD54L(5), RUVBL2(4), SETX(6), SI(5), SKIV2L2(1), SMARCA5(1), UGDH(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), UXS1(2)	32566432	162	68	151	66	46	30	26	23	36	1	0.927	1.000	1.000
480	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(7), ANAPC1(3), ANAPC2(4), ANAPC4(3), ANAPC5(6), ANAPC7(1), ATM(11), ATR(10), BUB1(2), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(4), CDC14B(1), CDC16(1), CDC20(1), CDC23(2), CDC25B(2), CDC6(3), CDC7(1), CDK4(2), CDK6(2), CDK7(1), CHEK2(1), CREBBP(3), CUL1(4), E2F3(3), EP300(6), ESPL1(8), GSK3B(2), MAD1L1(1), MAD2L1(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), PCNA(1), PKMYT1(2), PRKDC(9), RB1(3), RBL1(1), RBL2(2), SKP1(1), SKP2(3), SMAD2(1), SMAD3(1), SMC1A(1), SMC1B(5), TFDP1(1), TGFB1(1), TGFB2(2), YWHAE(3), YWHAH(1)	36545733	175	68	172	38	47	34	38	21	34	1	0.00885	1.000	1.000
481	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	87	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), CSNK1D(1), DRD1(5), EGF(4), EGFR(2), GJA1(1), GNA11(3), GNAI1(1), GNAI2(1), GNAQ(1), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HRAS(1), HTR2A(3), HTR2B(1), ITPR1(10), ITPR2(12), ITPR3(10), MAP3K2(2), MAPK7(4), NPR1(5), NPR2(1), PDGFC(2), PDGFRA(3), PDGFRB(7), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PRKACB(1), PRKACG(3), PRKCG(2), PRKG1(1), PRKG2(2), SOS2(1), SRC(2), TJP1(6), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4)	34810439	198	68	189	58	76	36	31	22	33	0	0.0226	1.000	1.000
482	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	158	ADORA2A(1), ADORA3(5), ADRA1A(4), ADRA1D(1), ADRA2A(1), ADRA2C(3), ADRB2(1), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKBR(3), CCR1(2), CCR10(2), CCR2(1), CCR4(4), CCR7(1), CCR9(1), CCRL2(2), CHML(5), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CMKLR1(1), CX3CR1(1), CXCR4(3), DRD1(5), DRD3(1), DRD5(5), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHR(4), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR35(1), GPR4(2), GPR50(2), GPR6(1), GPR83(1), GPR87(1), GRPR(1), HCRTR1(2), HRH2(2), HRH3(1), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR4(1), HTR5A(5), HTR7(1), LHCGR(2), MC3R(4), MC5R(3), MLNR(1), MTNR1A(1), MTNR1B(3), NMBR(1), NMUR1(1), NMUR2(3), NPY1R(3), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OR10A5(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(2), P2RY12(1), P2RY13(2), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(2), RGR(1), RRH(1), SSTR1(4), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(2)	33032127	195	67	191	68	67	30	55	27	16	0	0.0648	1.000	1.000
483	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(5), ADCY8(4), ARAF(2), ATF4(1), BRAF(4), CACNA1C(9), CALML3(1), CALML6(2), CAMK2D(1), CAMK4(2), CREBBP(3), EP300(6), GNAQ(1), GRIA1(3), GRIA2(1), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRM5(7), HRAS(1), ITPR1(10), ITPR2(12), ITPR3(10), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), RAP1B(3), RAPGEF3(4), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5)	27032743	152	66	144	47	48	21	25	19	37	2	0.257	1.000	1.000
484	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(6), ABCA10(3), ABCA12(14), ABCA13(13), ABCA2(6), ABCA3(7), ABCA4(8), ABCA5(8), ABCA6(6), ABCA7(7), ABCA8(6), ABCA9(10), ABCB1(7), ABCB10(2), ABCB11(4), ABCB5(7), ABCB6(4), ABCB8(1), ABCC1(1), ABCC10(5), ABCC11(3), ABCC12(5), ABCC3(5), ABCC4(5), ABCC5(4), ABCC6(6), ABCC8(1), ABCC9(3), ABCD1(1), ABCD2(2), ABCD3(1), ABCG1(3), ABCG2(1), ABCG4(4), ABCG5(3), ABCG8(2), CFTR(5), TAP1(4), TAP2(1)	31650608	184	65	176	47	53	38	24	36	31	2	0.00499	1.000	1.000
485	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADSL(2), ADSS(3), AK2(1), ALLC(2), AMPD1(4), AMPD2(2), AMPD3(4), APRT(1), ATIC(2), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), FHIT(1), GART(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IMPDH1(3), ITPA(1), NME1(1), NPR1(5), NPR2(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(2), PAPSS2(4), PDE4A(2), PDE4C(2), PDE4D(2), PDE5A(3), PDE6B(3), PDE6C(1), PDE6G(1), PDE7B(1), PDE8A(2), PDE9A(1), PFAS(7), PKLR(2), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(3), PRPS2(1), RRM1(2)	35941112	182	65	179	47	69	38	28	18	27	2	0.00495	1.000	1.000
486	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), AKAP1(2), AKAP10(2), AKAP11(6), AKAP12(5), AKAP2(9), AKAP3(2), AKAP4(1), AKAP5(1), AKAP6(6), AKAP7(2), AKAP9(9), ARHGEF1(3), GNA11(3), GNA14(1), GNA15(4), GNAI2(1), GNAL(3), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB2(1), GNB3(2), GNB5(1), GNG13(1), HRAS(1), ITPR1(10), PALM2(1), PDE1B(2), PDE1C(1), PDE4A(2), PDE4C(2), PDE4D(2), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(3), PRKD1(1), PRKD3(4), RHOA(1), RRAS(2), USP5(2)	31969506	169	63	163	68	58	34	30	21	24	2	0.587	1.000	1.000
487	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	88	CLK2(1), CLK3(3), CLK4(2), COL2A1(5), CPSF1(4), CPSF2(4), CPSF4(2), CSTF1(1), CSTF2(1), CSTF2T(1), CSTF3(4), DDX20(1), DHX15(4), DHX16(4), DHX38(2), DHX8(3), DICER1(10), FUS(2), LSM2(1), METTL3(2), NCBP2(2), NONO(1), NUDT21(1), PABPN1(2), PAPOLA(2), PHF5A(2), POLR2A(6), PPM1G(2), PRPF3(3), PRPF4B(1), PRPF8(9), PTBP1(3), PTBP2(1), RBM17(1), RBM5(1), RNGTT(4), SF3A2(1), SF3B1(4), SF3B2(3), SF3B5(1), SNRPA(1), SNRPB(1), SNRPE(3), SNRPN(2), SPOP(1), SRPK1(2), SRRM1(4), SUPT5H(2), U2AF2(3), XRN2(4)	27996168	130	59	125	31	43	19	19	23	26	0	0.0926	1.000	1.000
488	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	72	ABL1(7), ACTN1(1), AKT1(3), AKT2(2), AKT3(4), ANGPTL2(2), ARHGEF6(2), BCAR1(2), BRAF(4), CDC42(1), CRK(1), CSE1L(3), DOCK1(5), EPHB2(4), GRB7(3), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGB3BP(1), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MRAS(2), MYLK(11), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PIK3CB(3), PKLR(2), PLCG1(1), PLCG2(7), PTEN(2), PTK2(3), ROCK1(6), ROCK2(2), SHC1(2), SOS2(1), SRC(2), TERF2IP(1), TLN1(11), TLN2(6), ZYX(1)	31977133	167	59	163	47	53	32	23	24	35	0	0.0657	1.000	1.000
489	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	84	ACVR1B(2), ACVR1C(2), ACVRL1(1), AMH(2), AMHR2(5), BMP2(3), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMP8A(1), BMP8B(1), BMPR1A(4), BMPR2(3), CHRD(2), COMP(4), CREBBP(3), CUL1(4), DCN(1), E2F4(3), E2F5(3), EP300(6), GDF5(2), GDF6(1), GDF7(2), INHBA(2), INHBB(2), INHBC(1), LEFTY2(1), LTBP1(2), MYC(2), NODAL(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), RBL1(1), RBL2(2), RHOA(1), ROCK1(6), ROCK2(2), RPS6KB2(4), SKP1(1), SMAD2(1), SMAD3(1), SMAD7(1), SMAD9(3), SMURF2(1), SP1(1), TFDP1(1), TGFB1(1), TGFB2(2), THBS1(7), THBS2(4), THBS3(1), ZFYVE16(5), ZFYVE9(4)	26251699	137	58	132	39	40	26	24	19	28	0	0.132	1.000	1.000
490	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	89	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(9), CACNA1F(2), CACNA1S(6), CALML3(1), CALML6(2), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), ELK1(2), FSHB(1), GNA11(3), GNAQ(1), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(10), ITPR2(12), ITPR3(10), LHB(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP2(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLD2(5), PRKACB(1), PRKACG(3), SOS2(1), SRC(2)	32763117	168	58	160	61	56	28	27	20	35	2	0.335	1.000	1.000
491	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(3), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMP8A(1), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(1), DHH(2), FBXW11(2), GLI1(6), GLI2(5), GLI3(14), GSK3B(2), HHIP(5), LRP2(10), PRKACB(1), PRKACG(3), PTCH1(6), PTCH2(8), SMO(2), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1), ZIC2(5)	16872290	119	57	115	39	50	24	16	11	18	0	0.149	1.000	1.000
492	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	95	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), CALML3(1), CALML6(2), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(3), CTNNB1(9), DCT(3), DVL1(4), DVL2(4), DVL3(2), EDNRB(2), EP300(6), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GSK3B(2), HRAS(1), KIT(4), LEF1(3), MITF(3), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), POMC(1), PRKACB(1), PRKACG(3), PRKCG(2), TCF7(2), TCF7L1(4), TCF7L2(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1)	30011060	173	56	168	68	73	31	22	23	23	1	0.215	1.000	1.000
493	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	BRAF(4), CHUK(1), CREB1(2), DAXX(6), ELK1(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP3K9(4), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK4(1), MAPK6(2), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(2), MEF2C(2), MEF2D(2), MKNK2(3), MYC(2), NFKBIA(2), PAK2(3), RELA(3), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), RPS6KA5(4), RPS6KB2(4), SHC1(2), SP1(1), STAT1(3), TGFB1(1), TGFB2(2), TRADD(1), TRAF2(1)	26370247	130	56	124	44	29	24	24	11	42	0	0.690	1.000	1.000
494	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	80	ABL1(7), ABL2(2), AKT1(3), AKT2(2), AKT3(4), ARAF(2), BAD(1), BRAF(4), BTC(1), CAMK2D(1), CBL(5), CBLB(2), CBLC(1), CRK(1), CRKL(2), EGF(4), EGFR(2), ELK1(2), ERBB2(6), ERBB3(6), ERBB4(6), GSK3B(2), HRAS(1), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK9(1), MYC(2), NCK1(3), NCK2(2), NRG1(3), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), RPS6KB2(4), SHC1(2), SHC2(2), SHC4(2), SOS2(1), SRC(2), STAT5A(2)	26749205	139	55	134	39	39	25	18	14	43	0	0.184	1.000	1.000
495	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	AKT1(3), AKT2(2), AKT3(4), ANGPTL2(2), ARHGAP4(2), ARHGEF11(6), BTK(1), CDC42(1), GDI1(1), GDI2(3), INPPL1(5), ITPR1(10), ITPR2(12), ITPR3(10), LIMK1(1), MYLK(11), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDK1(1), PIK3CD(2), PIK3CG(5), PIK3R1(2), PPP1R13B(1), PTEN(2), RACGAP1(3), ROCK1(6), ROCK2(2), SAG(1), WASF1(1), WASL(6)	18815181	117	55	106	35	35	19	17	13	33	0	0.331	1.000	1.000
496	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(6), BCAR1(2), CDC42(1), CDH5(2), CLDN17(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTNND1(3), CXCR4(3), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(2), ITGA4(1), ITGAL(3), ITGAM(1), ITGB2(1), ITK(1), JAM2(2), MAPK11(1), MAPK12(1), MAPK13(1), MLLT4(5), MMP2(2), MMP9(4), MYL9(1), NCF2(1), NCF4(1), NOX1(4), NOX3(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RAPGEF3(4), RAPGEF4(3), RHOA(1), RHOH(2), ROCK1(6), ROCK2(2), SIPA1(3), THY1(1), TXK(1), VAV1(6), VCL(3)	34052626	155	54	154	61	54	31	17	24	26	3	0.531	1.000	1.000
497	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	51	ASH1L(9), ASH2L(3), CARM1(2), CTCFL(1), DOT1L(1), EED(3), EHMT1(5), EHMT2(6), EZH1(1), EZH2(3), FBXO11(2), HCFC1(5), HSF4(1), KDM6A(8), MEN1(5), NSD1(7), OGT(2), PAXIP1(1), PPP1CA(1), PRDM2(8), PRDM9(5), PRMT5(1), PRMT6(1), PRMT7(2), RBBP5(1), SETD2(9), SETD8(1), SETDB1(3), SETMAR(1), SMYD3(1), STK38(2), SUV39H2(3), SUV420H1(4), SUV420H2(2), SUZ12(2), WHSC1(4)	31395507	116	53	107	27	21	18	19	19	39	0	0.221	1.000	1.000
498	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(1), ALG10(1), ALG10B(2), ALG11(3), ALG12(4), ALG13(2), ALG9(1), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT5(2), CHPF(2), CHST1(1), CHST11(3), CHST12(1), CHST14(3), CHST2(2), CHST4(1), CHST6(4), CHSY1(2), DDOST(1), EXT1(2), EXT2(4), EXTL1(3), EXTL2(2), EXTL3(6), GALNT1(3), GALNT10(6), GALNT13(2), GALNT14(1), GALNT2(2), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GANAB(4), GCNT4(1), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT3(3), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(3), NDST3(3), NDST4(3), OGT(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), WBSCR17(2), XYLT1(5), XYLT2(7)	30652654	144	53	139	41	50	26	31	16	21	0	0.0534	1.000	1.000
499	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	86	AKT1(3), AKT3(4), BCAR1(2), CAPN1(1), CAPN11(1), CAPN2(1), CAPN3(4), CAPN5(3), CAPN9(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(5), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(7), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), MAP2K3(1), MAP2K6(3), MAPK10(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PIK3R2(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), ROCK1(6), ROCK2(2), SDCCAG8(2), SEPP1(1), SHC1(2), SORBS1(1), SRC(2), TLN1(11), TNS1(4), VCL(3), ZYX(1)	36212078	162	53	158	47	46	35	30	17	34	0	0.0483	1.000	1.000
500	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	77	ABL1(7), ATM(11), BUB1(2), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(4), CDC14B(1), CDC20(1), CDC25B(2), CDC6(3), CDC7(1), CDH1(1), CDK4(2), CHEK2(1), E2F3(3), E2F4(3), E2F5(3), EP300(6), ESPL1(8), GSK3B(2), HDAC4(4), HDAC5(2), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), MPEG1(2), PCNA(1), PRKDC(9), PTPRA(1), RB1(3), RBL1(1), SKP2(3), TBC1D8(3), TFDP1(1), TGFB1(1)	29744578	140	52	138	26	41	24	29	24	21	1	0.00139	1.000	1.000
501	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	78	ACVR1B(2), ACVRL1(1), AKT1(3), BMPR1A(4), BMPR2(3), BUB1(2), CDIPT(3), CDKL1(1), CLK1(3), CLK2(1), CLK4(2), COL4A3BP(1), CSNK2A1(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MAP3K10(4), MOS(3), OCRL(1), PAK4(2), PIK3C2A(5), PIK3C2B(12), PIK3CB(3), PIK3CG(5), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCQ(3), PRKD1(1), PRKG1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), STK11(4), VRK1(1)	30441305	143	51	139	44	49	20	17	22	35	0	0.282	1.000	1.000
502	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(11), CCNA1(3), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CDK7(1), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(3), E2F5(3), GBA2(3), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), MYC(2), MYT1(12), NACA(13), PCNA(1), POLA2(1), POLE(8), POLE2(1), PRIM1(1), RB1(3), RBL1(1), RPA1(1), RPA2(3), RPA3(2), TFDP1(1), TNXB(13)	20946383	126	49	124	34	39	20	26	24	16	1	0.0585	1.000	1.000
503	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(1), BDKRB1(1), BDKRB2(1), C1QA(1), C1QB(1), C1QC(1), C1R(1), C1S(6), C2(6), C3(11), C3AR1(2), C5(2), C5AR1(1), C6(6), C7(4), C8A(5), C9(3), CD46(1), CD55(1), CD59(2), CFB(3), CFD(1), CFH(6), CFI(3), CR1(5), F10(4), F11(1), F12(3), F13A1(3), F13B(2), F8(9), FGA(6), FGB(4), FGG(2), KLKB1(2), KNG1(2), MASP1(2), PLAT(2), PLG(1), PROC(1), PROS1(2), SERPINA1(2), SERPINA5(2), SERPINC1(3), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(2), THBD(3), VWF(5)	23215215	143	49	136	40	38	23	26	22	33	1	0.112	1.000	1.000
504	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	85	AKT1(3), AKT2(2), AKT3(4), CARD11(3), CBL(5), CBLB(2), CBLC(1), CD3E(1), CD4(2), CD8B(2), CDC42(1), CDK4(2), CHUK(1), GRAP2(2), HRAS(1), IKBKB(4), ITK(1), LCK(1), MALT1(3), NCK1(3), NCK2(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKCQ(3), PTPN6(4), PTPRC(3), RASGRP1(2), RHOA(1), SOS2(1), TEC(2), VAV1(6), ZAP70(6)	25012384	130	48	124	43	42	29	13	17	28	1	0.246	1.000	1.000
505	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	55	APC(8), AXIN1(4), CCND2(3), CCND3(1), CSNK1E(1), CTNNB1(9), DVL1(4), DVL2(4), DVL3(2), FBXW2(2), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GSK3B(2), LDLR(1), MAPK10(1), MAPK9(1), MYC(2), PAFAH1B1(1), PPP2R5E(1), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(3), PRKD1(1), RHOA(1), SFRP4(1), TCF7(2), WNT1(1), WNT10A(1), WNT11(1), WNT2B(3), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2)	15807685	102	48	98	34	43	23	7	16	13	0	0.0920	1.000	1.000
506	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	116	ARAF(2), BRAF(4), FASLG(1), FCER1G(1), HLA-A(7), HLA-G(3), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), ITGAL(3), ITGB2(1), KIR2DL3(2), KIR3DL1(3), KLRC3(2), LCK(1), NCR1(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PRKCG(2), PTPN6(4), RAC2(1), SHC1(2), SHC2(2), SHC4(2), SOS2(1), SYK(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(6), ZAP70(6)	27768019	125	47	120	45	41	22	14	20	27	1	0.417	1.000	1.000
507	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(2), BAD(1), CABIN1(6), CAMK4(2), CD3E(1), CD69(1), CREBBP(3), CSNK2A1(1), EGR3(2), EP300(6), FCER1A(1), FOSL1(1), GATA3(3), GATA4(1), GSK3A(2), GSK3B(2), HRAS(1), IL1B(1), IL2RA(1), IL6(1), ITK(1), JUNB(1), KPNA5(1), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(2), MYF5(2), NCK2(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(6), OPRD1(2), P2RX7(2), PPP3CC(2), PTPRC(3), RELA(3), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(6), VAV1(6), XPO5(2)	24157333	117	46	112	33	41	23	14	13	25	1	0.0812	1.000	1.000
508	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	56	AKT1(3), AKT2(2), AKT3(4), BAD(1), CDC42(1), CREB1(2), CREB5(1), ERBB4(6), F2RL2(2), GSK3A(2), GSK3B(2), IFI27(1), INPPL1(5), IRS2(4), IRS4(4), MET(4), MYC(2), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PARD3(7), PARD6A(1), PDK1(1), PIK3CD(2), PPP1R13B(1), PREX1(9), PTEN(2), PTK2(3), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS2(1), TSC1(1), TSC2(8), YWHAE(3), YWHAH(1)	18689326	99	45	92	39	27	14	13	15	30	0	0.811	1.000	1.000
509	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	94	AKT1(3), AKT2(2), AKT3(4), CASP8(2), CCL3(1), CD14(3), CD40(1), CD80(1), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IKBKB(4), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(1), IRF5(1), IRF7(2), LBP(1), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), RELA(3), STAT1(3), TBK1(1), TICAM1(2), TLR1(5), TLR2(2), TLR3(3), TLR4(1), TLR5(3), TLR6(4), TLR8(2), TLR9(5), TRAF6(1)	23541289	112	44	108	35	31	17	20	17	27	0	0.272	1.000	1.000
510	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(8), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADIPOR1(2), AKT1(3), AKT2(2), AKT3(4), CHUK(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(4), IRS2(4), IRS4(4), JAK1(1), JAK2(2), JAK3(3), LEPR(7), MAPK10(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NPY(2), PCK1(3), PCK2(5), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(4), PRKCQ(3), RELA(3), RXRA(1), RXRB(1), RXRG(1), SLC2A1(3), STAT3(2), STK11(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2)	22807762	125	44	121	45	36	26	18	15	29	1	0.391	1.000	1.000
511	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	39	ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), ASCC3(5), ATP13A2(2), DDX18(1), DDX23(1), DDX4(6), DDX41(2), DDX47(5), DDX50(7), DDX51(1), DDX54(2), DDX55(1), DDX56(2), DHFR(1), DHX58(4), EP400(8), ERCC2(2), FPGS(3), GCH1(1), GGH(2), IFIH1(7), MOV10L1(6), NUDT8(1), QDPR(2), RAD54L(5), RUVBL2(4), SETX(6), SKIV2L2(1), SMARCA5(1)	16349756	103	43	96	46	24	22	15	15	26	1	0.950	1.000	1.000
512	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(5), CCKBR(3), CCR2(1), CELSR1(5), CELSR2(11), CELSR3(12), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(3), EMR3(1), FSHR(4), GHRHR(1), GNRHR(1), GPR116(3), GPR132(1), GPR133(9), GPR135(1), GPR143(1), GPR18(2), GPR56(1), GPR61(1), GPR84(1), GRPR(1), LGR6(3), LPHN2(10), LPHN3(1), LTB4R2(1), OR2M4(3), P2RY13(2), PTGFR(2), SMO(2), TAAR5(2), TSHR(3)	17942239	103	41	103	38	40	18	19	15	11	0	0.157	1.000	1.000
513	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(11), ATR(10), BAI1(5), CASP8(2), CASP9(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(1), CCNG2(2), CDK4(2), CDK6(2), CHEK2(1), DDB2(1), EI24(1), GTSE1(2), MDM2(2), PERP(1), PTEN(2), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN1(1), SESN2(3), SESN3(2), STEAP3(3), THBS1(7), TNFRSF10B(2), TP73(1), TSC2(8), ZMAT3(2)	17862123	93	40	90	29	34	20	16	9	14	0	0.188	1.000	1.000
514	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	56	AKT1(3), AKT2(2), AKT3(4), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD72(2), CD81(2), CHUK(1), FCGR2B(2), GSK3B(2), HRAS(1), IFITM1(1), IKBKB(4), INPP5D(1), LYN(1), MALT1(3), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PTPN6(4), RAC2(1), RASGRP3(2), SYK(2), VAV1(6)	17922906	105	40	99	32	33	23	11	13	24	1	0.122	1.000	1.000
515	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	91	ANK2(10), B3GALT4(2), CDR1(2), DGKI(5), IL6ST(4), RPL11(1), RPL12(1), RPL14(1), RPL15(2), RPL18(2), RPL18A(1), RPL19(1), RPL24(1), RPL28(3), RPL32(2), RPL34(1), RPL35(1), RPL36(1), RPL3L(2), RPL4(3), RPL7A(2), RPLP0(1), RPLP2(1), RPS11(2), RPS25(2), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5), RPS6KB2(4), RPSA(1), SLC36A2(1), TSPAN9(1), UBB(1), UBC(2)	14430663	76	39	74	55	15	11	17	8	24	1	1.000	1.000	1.000
516	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(2), INPPL1(5), ISYNA1(1), ITPK1(1), ITPKB(3), MINPP1(1), MIOX(1), OCRL(1), PI4KA(4), PI4KB(2), PIK3C3(2), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PTEN(2), SYNJ1(2), SYNJ2(3)	20041512	84	38	82	31	25	13	13	13	20	0	0.503	1.000	1.000
517	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(3), AKT2(2), AKT3(4), BRD4(6), CBL(5), CDC42(1), F2RL2(2), FLOT2(1), GSK3A(2), GSK3B(2), INPPL1(5), IRS2(4), IRS4(4), LNPEP(2), PARD3(7), PARD6A(1), PDK1(1), PIK3CD(2), PIK3R1(2), PTEN(2), RPS6KA1(2), RPS6KA2(2), SHC1(2), SORBS1(1), SOS2(1), YWHAE(3), YWHAH(1)	14537210	70	36	63	26	19	12	7	10	22	0	0.738	1.000	1.000
518	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	39	AGL(5), ENPP3(3), GAA(2), GANAB(4), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(3), HK2(3), HK3(4), MGAM(1), PGM1(1), PYGB(2), PYGL(2), PYGM(2), SI(5), UGDH(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1), UXS1(2)	15453146	71	35	67	22	26	14	9	8	14	0	0.348	1.000	1.000
519	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(3), CDC7(1), CDT1(1), DIAPH2(1), MCM10(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), NACA(13), PCNA(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), PRIM1(1), RFC1(4), RFC2(2), RFC3(1), RPA1(1), RPA2(3), RPA3(2), RPS27A(1), UBB(1), UBC(2)	14211732	76	34	73	42	25	11	15	12	11	2	0.993	1.000	1.000
520	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(3), AKT2(2), AKT3(4), BRAF(4), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PRKAA1(1), PRKAA2(1), RICTOR(6), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5), RPS6KB2(4), STK11(4), TSC1(1), TSC2(8), ULK1(3), ULK3(1), VEGFC(1)	13998496	73	34	69	26	22	14	9	5	23	0	0.738	1.000	1.000
521	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	64	AKT1(3), AKT2(2), AKT3(4), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NOS3(9), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PRKCG(2), PTGS2(1), PTK2(3), PXN(1), RAC2(1), SHC2(2), SPHK1(1), SPHK2(1), SRC(2)	18163500	97	34	91	34	32	20	15	10	20	0	0.404	1.000	1.000
522	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	AKT1(3), ASAH1(1), ATF1(1), BRAF(4), CAMP(2), CREB1(2), CREB5(1), CREBBP(3), CRKL(2), DAG1(2), EGR3(2), ELK1(2), FRS2(1), GNAQ(1), MAP1B(7), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), NTRK1(3), OPN1LW(2), PIK3CD(2), PIK3R1(2), SHC1(2), SRC(2), TERF2IP(1), TH(1)	13561813	69	34	68	28	23	10	11	7	18	0	0.661	1.000	1.000
523	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	82	AK3(1), CAD(6), CTPS2(1), DCK(1), DPYD(4), DTYMK(1), DUT(1), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME7(1), NT5C1B(3), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), PRIM1(1), RRM1(2), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(2)	21343720	87	33	86	27	26	16	16	19	10	0	0.221	1.000	1.000
524	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(4), CPEB1(2), EGFR(2), ERBB2(6), ERBB4(6), ETS1(3), ETS2(2), ETV6(3), ETV7(1), FMN2(14), NOTCH1(10), NOTCH2(4), NOTCH3(7), NOTCH4(5), PIWIL1(1), PIWIL2(3), PIWIL3(3), PIWIL4(1), SOS2(1)	13957199	78	33	73	41	24	10	17	11	16	0	0.994	1.000	1.000
525	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(1), BFAR(2), BTK(1), CAD(6), CASP10(2), CASP8(2), CSNK1A1(1), DAXX(6), DEDD(2), EGFR(2), EPHB2(4), FAF1(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PTPN13(8), RALBP1(2), ROCK1(6), SMPD1(1), TPX2(2), TRAF2(1)	19703168	84	33	81	30	20	18	17	13	16	0	0.596	1.000	1.000
526	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	109	ATP12A(8), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7A2(1), COX7B2(2), COX7C(1), COX8C(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV2(3), SDHA(6), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1), UQCRH(2)	14022199	73	30	70	25	19	15	11	15	12	1	0.600	1.000	1.000
527	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(4), APH1A(3), CREBBP(3), CTBP2(3), DLL4(2), DTX1(3), DTX2(5), DVL1(4), DVL2(4), DVL3(2), EP300(6), JAG1(2), JAG2(3), LFNG(1), MAML1(5), MAML2(3), NCOR2(5), NOTCH1(10), NOTCH2(4), NOTCH3(7), NOTCH4(5), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RBPJL(1), SNW1(1)	19529015	92	29	92	49	31	26	17	10	8	0	0.892	1.000	1.000
528	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AASS(2), ACAT1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(6), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(7), OGDH(5), OGDHL(2), PLOD1(2), RDH11(2), SETDB1(3), SHMT1(2), SHMT2(4), SPCS1(1), SUV39H2(3), TMLHE(1)	15386706	65	28	61	23	20	12	14	7	12	0	0.467	1.000	1.000
529	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	68	AKT1(3), AKT2(2), AKT3(4), BTK(1), FCER1A(1), FCER1G(1), GAB2(2), HRAS(1), INPP5D(1), LYN(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(7), PRKCE(1), RAC2(1), SOS2(1), SYK(2), VAV1(6)	17584719	81	28	79	34	24	16	9	10	21	1	0.728	1.000	1.000
530	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	35	AARS(1), CARS2(2), DARS(1), DARS2(2), EARS2(1), EPRS(1), FARS2(2), FARSA(2), FARSB(1), GARS(7), IARS(4), KARS(2), LARS2(2), MARS2(2), NARS2(2), PARS2(2), QARS(2), RARS(1), RARS2(4), TARS(2), VARS(4), VARS2(3), WARS(2)	14049765	52	26	49	18	16	12	8	7	9	0	0.495	1.000	1.000
531	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	CHUK(1), DAXX(6), EGF(4), EGFR(2), ETS1(3), ETS2(2), HOXA7(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK13(1), MAPK8(2), NFKBIA(2), PPP2CA(1), PRKCE(1), PRKCG(2), PRKCQ(3), RELA(3), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1)	13049852	62	26	60	23	14	11	11	10	16	0	0.632	1.000	1.000
532	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(4), ADRA1D(1), ADRA2A(1), ADRA2C(3), ADRB2(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), DRD1(5), DRD3(1), DRD5(5), HRH2(2), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR4(1), HTR5A(5), HTR7(1)	7050764	51	26	48	21	19	9	12	6	5	0	0.553	1.000	1.000
533	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	23	BRCA1(6), CARM1(2), CREBBP(3), EP300(6), ESR1(1), GRIP1(1), GTF2A1(1), GTF2E1(1), HDAC4(4), HDAC5(2), HDAC6(1), MEF2C(2), NCOR2(5), NR0B1(3), NRIP1(1), POLR2A(6), TBP(3)	12489054	48	25	45	21	14	7	11	6	10	0	0.820	1.000	1.000
534	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	APAF1(3), BIRC2(2), CASP2(3), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CRADD(2), DAXX(6), DFFB(1), LMNB1(1), LMNB2(1), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK8(2), MDM2(2), NFKBIA(2), NUMA1(3), PAK2(3), PRKDC(9), PSEN1(1), PSEN2(1), PTK2(3), RASA1(4), RB1(3), RELA(3), SPTAN1(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	18822670	80	25	78	25	15	12	20	11	22	0	0.575	1.000	1.000
535	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(1), AZIN1(1), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(1), ETV6(3), GFRA1(3), GSTP1(1), HERPUD1(2), HSPA8(3), IDI1(1), MYF6(1), NCKAP1(4), NCOA4(1), NR1D2(1), PER1(5), PER2(5), PPP1R3C(2), PURA(1), TUBB3(3), UCP3(1), ZFR(3)	9346469	47	24	44	26	12	7	6	10	12	0	0.991	1.000	1.000
536	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(2), ALAS2(3), AOC2(3), AOC3(3), ATP6V0C(1), CHDH(2), CPT1B(5), DAO(2), DMGDH(4), GARS(7), GLDC(1), PLCB2(5), PLCG1(1), PLCG2(7), SARDH(3), SHMT1(2), SHMT2(4), TARS(2)	11867513	59	24	57	21	26	14	8	5	6	0	0.314	1.000	1.000
537	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(3), B3GAT3(2), CHPF(2), CHST11(3), CHST12(1), CHST14(3), CHSY1(2), DSE(4), XYLT1(5), XYLT2(7)	4206947	32	23	29	13	13	4	7	2	6	0	0.577	1.000	1.000
538	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	41	CBL(5), CSK(1), DAG1(2), DTYMK(1), EPHB2(4), FBXW7(6), GRAP2(2), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PLCG1(1), PTPRC(3), RASGRP1(2), RASGRP2(1), RASGRP3(2), SOS2(1), VAV1(6), ZAP70(6)	13912299	63	23	63	21	20	13	9	8	12	1	0.451	1.000	1.000
539	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(3), BAD(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(6), DFFB(1), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(3), PTPN13(8), TFG(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TRAF6(1)	12012910	58	22	54	20	14	13	12	6	13	0	0.647	1.000	1.000
540	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	25	CASP10(2), CASP7(2), CASP8(2), CFLAR(3), DAXX(6), DFFB(1), FAF1(1), LMNB1(1), LMNB2(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PAK2(3), PRKDC(9), PTPN13(8), RB1(3), SPTAN1(3)	10989203	55	22	52	17	8	7	11	13	16	0	0.675	1.000	1.000
541	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(2), AGXT2(2), ALAS2(3), AOC2(3), AOC3(3), CHDH(2), DAO(2), DMGDH(4), GARS(7), GLDC(1), HSD3B7(3), PHGDH(2), PSAT1(2), RDH11(2), SARDH(3), SHMT1(2), SHMT2(4), TARS(2)	11776822	49	22	47	20	25	12	5	5	2	0	0.470	1.000	1.000
542	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(4), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(2), LCT(6), MAN2B1(2), MAN2B2(2), MANBA(2), NAGLU(2), NEU4(2)	9841351	43	22	42	19	12	7	8	3	13	0	0.782	1.000	1.000
543	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	36	AKT1(3), AKT2(2), AKT3(4), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(4), ITPKB(3), LYN(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CD(2), PIK3R1(2), PLCG2(7), PPP1R13B(1), SHC1(2), SOS2(1), SYK(2), VAV1(6)	12597183	54	22	52	24	21	8	4	9	11	1	0.772	1.000	1.000
544	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(1), BAD(1), BRAF(4), CREB1(2), CREB5(1), DUSP6(2), DUSP9(1), MKNK2(3), MOS(3), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS2(1)	7571877	25	22	24	14	7	3	4	1	10	0	0.984	1.000	1.000
545	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	48	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(1), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2J2(4), CYP2U1(1), CYP4A22(2), CYP4F2(2), EPHX2(1), GGT1(1), GPX5(4), GPX6(1), LTA4H(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1)	10354536	51	20	50	29	19	9	12	3	7	1	0.952	1.000	1.000
546	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(7), ARRB2(3), CALML3(1), CALML6(2), CAMK2D(1), CLCA1(2), CLCA2(2), CLCA4(2), CNGA3(4), CNGA4(2), GNAL(3), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDC(1), PDE1C(1), PRKACB(1), PRKACG(3), PRKG1(1), PRKG2(2)	7855564	41	20	39	18	15	8	10	4	4	0	0.696	1.000	1.000
547	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	30	AKT1(3), BAD(1), CBL(5), CFLAR(3), CRKL(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), MYC(2), PIK3R1(2), PTPN6(4), SHC1(2), STAT5A(2), SYK(2)	8005974	36	20	35	19	11	5	6	5	9	0	0.964	1.000	1.000
548	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	29	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CYP4F2(2), EPX(4), GGT1(1), LPO(6), LTA4H(2), MPO(2), PLA2G3(2), PLA2G6(4), PRDX1(1), PRDX2(1), PRDX5(2), PTGDS(2), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1), TPO(7)	7387893	47	20	46	22	20	5	11	3	7	1	0.823	1.000	1.000
549	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	24	AKT1(3), AKT2(2), AKT3(4), BAD(1), GSK3A(2), GSK3B(2), IL4R(3), IRS2(4), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(2), SOS2(1), STAT6(5)	8379007	42	20	39	18	16	10	3	6	7	0	0.635	1.000	1.000
550	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(2), CD97(2), CRHR1(2), CRHR2(1), ELTD1(5), EMR1(3), EMR2(3), GHRHR(1), GIPR(2), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(10), LPHN3(1), VIPR1(1), VIPR2(1)	7558705	41	19	41	17	9	9	5	11	7	0	0.542	1.000	1.000
551	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	33	CDK7(1), GTF2E1(1), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3E(5), TAF5(1), TAF6(2), TAF9(2), TBP(3)	8457759	39	19	37	17	16	5	6	2	10	0	0.889	1.000	1.000
552	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(2), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ATP6V0C(1), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(6), GCDH(2), HADHA(1), PLOD1(2), SHMT1(2), SHMT2(4), TMLHE(1)	10380977	40	18	36	18	13	9	11	0	7	0	0.715	1.000	1.000
553	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	27	AKR1D1(1), ARSB(2), ARSE(1), HSD11B1(1), HSD17B2(2), HSD3B1(2), STS(4), SULT2A1(1), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1)	6746995	30	17	27	12	6	7	6	4	7	0	0.746	1.000	1.000
554	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	23	AKR1B1(1), FBP2(1), GAA(2), GANAB(4), GCK(1), GLB1(2), HK1(3), HK2(3), HK3(4), LCT(6), MGAM(1), PFKM(3), PFKP(1), PGM1(1)	8931060	33	17	33	13	16	5	5	1	6	0	0.470	1.000	1.000
555	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(2), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3)	4406013	30	17	28	11	10	5	6	1	8	0	0.392	1.000	1.000
556	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10A(1), RPL10L(2), RPL11(1), RPL12(1), RPL14(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL24(1), RPL28(3), RPL32(2), RPL34(1), RPL35(1), RPL36A(2), RPL36AL(1), RPL3L(2), RPS11(2), RPS25(2), RPS27(1), RPS28(1), RPSA(1)	6369092	32	17	31	11	9	3	9	0	11	0	0.796	1.000	1.000
557	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(3), EIF4A2(2), EIF4B(3), EIF4G1(8), EIF4G2(1), EIF4G3(7), FKBP1A(1), PDK2(3), PIK3R1(2), PPP2CA(1), PTEN(2), TSC1(1), TSC2(8)	7113432	42	17	40	14	14	9	10	4	5	0	0.577	1.000	1.000
558	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(4), CHAT(4), DBH(1), DDC(1), GAD1(6), GAD2(5), HDC(1), PAH(1), SLC18A3(3), TH(1), TPH1(2)	4094886	30	16	30	13	11	2	9	2	5	1	0.596	1.000	1.000
559	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	34	AGT(1), AGTR2(1), CAMK2D(1), GNA11(3), GNAI1(1), GNB1(2), HRAS(1), JAK2(2), MAPK8(2), MAPT(3), MYLK(11), PLCG1(1), SHC1(2), STAT1(3), STAT3(2), STAT5A(2), SYT1(1)	10427356	39	16	39	21	14	7	6	5	7	0	0.911	1.000	1.000
560	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(4), GLB1(2), LCT(6), NEU4(2), PPAP2B(2), PPAP2C(1), SMPD1(1), SPTLC1(3), SPTLC2(1), UGCG(1)	6862460	32	16	32	12	11	9	3	2	7	0	0.283	1.000	1.000
561	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	30	AKR1B1(1), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(2), HK1(3), HK2(3), HK3(4), HSD3B7(3), LCT(6), MGAM(1), PFKL(2), PFKM(3), PFKP(1), PGM1(1), RDH11(2)	10363589	37	16	37	15	19	6	5	2	5	0	0.442	1.000	1.000
562	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(3), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(2), GNPDA1(2), GNPDA2(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(4), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PHPT1(1), RENBP(1)	8020922	37	16	37	15	17	4	8	4	4	0	0.674	1.000	1.000
563	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	24	AKT1(3), AKT2(2), AKT3(4), CISH(1), IARS(4), IL4R(3), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PPP1R13B(1), SHC1(2), SOS2(1), SRC(2), STAT6(5), TYK2(2)	9007025	37	16	35	16	11	6	6	6	8	0	0.802	1.000	1.000
564	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	16	AHCY(2), AMD1(1), DNMT3A(8), DNMT3B(5), MARS2(2), MTR(7), TAT(1)	5611264	26	15	23	15	7	5	5	2	6	1	0.909	1.000	1.000
565	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(2), C6(6), C7(4), ICAM1(2), IL6(1), ITGA4(1), ITGAL(3), ITGB2(1), SELP(3)	6874289	34	15	34	14	10	8	5	2	9	0	0.533	1.000	1.000
566	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), DNMT3A(8), DNMT3B(5), MARS2(2), MTR(7)	4854061	24	15	21	14	7	4	5	2	5	1	0.901	1.000	1.000
567	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(3), GNAQ(1), GNB1(2), MYLK(11), PLCB1(1), PPP1R12B(1), ROCK1(6)	5762081	31	15	31	12	6	9	4	5	6	1	0.653	1.000	1.000
568	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(1), EPRS(1), FARS2(2), GARS(7), IARS(4), KARS(2), LARS2(2), MARS2(2), QARS(2), RARS(1), TARS(2), WARS(2)	8839491	29	14	27	10	9	7	6	5	2	0	0.542	1.000	1.000
569	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	25	AHCY(2), CARM1(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(2), MARS2(2), METTL2B(2), METTL6(1), PAPSS1(2), PAPSS2(4), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), SCLY(2), SEPHS2(5)	6745978	33	14	32	13	10	9	10	2	2	0	0.456	1.000	1.000
570	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(2), LCT(6), NAGLU(2)	5827840	26	14	25	16	5	7	3	2	9	0	0.957	1.000	1.000
571	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(3), EIF2B5(1), GSK3B(2), IGF1R(6), INPPL1(5), PDK2(3), PIK3R1(2), PPP2CA(1), PTEN(2)	4904473	25	14	22	10	6	4	3	4	8	0	0.827	1.000	1.000
572	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	12	GTF2A1(1), GTF2E1(1), NCOA2(3), NCOA3(3), NCOR2(5), POLR2A(6), RXRA(1), TBP(3)	6334233	23	14	22	25	7	2	5	2	6	1	1.000	1.000	1.000
573	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CD(2), PIK3R1(2), SYT1(1), TRAF2(1), TRAF5(1), TRAF6(1)	9094632	37	14	37	13	10	8	8	5	6	0	0.343	1.000	1.000
574	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(3), EIF4A2(2), EIF4G1(8), EIF4G2(1), EIF4G3(7), GHR(1), PDK2(3), PIK3R1(2), PTEN(2)	6168273	29	13	27	10	7	7	7	3	5	0	0.702	1.000	1.000
575	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), HSD3B7(3), PLA2G12B(1), PLA2G3(2), PLA2G6(4), RDH11(2)	6660072	36	13	35	13	9	5	11	7	4	0	0.690	1.000	1.000
576	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST2(3), HS3ST3B1(1), XYLT1(5), XYLT2(7)	1926000	18	12	16	13	6	6	2	1	3	0	0.887	1.000	1.000
577	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST2(3), HS3ST3B1(1), XYLT1(5), XYLT2(7)	1926000	18	12	16	13	6	6	2	1	3	0	0.887	1.000	1.000
578	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(3), PPP3CC(2), SYNJ1(2), SYNJ2(3), SYT1(1)	6244918	25	12	25	11	4	6	3	4	8	0	0.768	1.000	1.000
579	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(2), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(11), NCF2(1), PDGFRA(3), PIK3R1(2), PPP1R12B(1), RALBP1(2), TRIO(9), VAV1(6), WASF1(1)	8654864	43	12	41	16	14	9	5	7	6	2	0.575	1.000	1.000
580	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(6), PGM1(1), PYGL(2), PYGM(2), TPI1(3)	3782512	17	11	17	11	7	4	1	1	4	0	0.844	1.000	1.000
581	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), LCT(6), NAGLU(2)	4109106	19	11	19	12	4	5	2	2	6	0	0.913	1.000	1.000
582	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(3), EP300(6), IL7(1), IL7R(3), JAK1(1), JAK3(3), LCK(1), PIK3R1(2), STAT5A(2)	6926132	22	11	21	11	8	3	5	2	4	0	0.842	1.000	1.000
583	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(3), EP300(6), LPL(4), NCOA2(3), PPARG(1), RXRA(1)	5129266	18	11	18	10	6	2	4	2	4	0	0.894	1.000	1.000
584	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	BCAR1(2), CRKL(2), GNAQ(1), HRAS(1), MAP2K3(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PLCG1(1), SHC1(2), SRC(2), SYT1(1)	6945660	23	11	23	14	6	4	3	4	6	0	0.955	1.000	1.000
585	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), PDE1B(2), PLCB1(1), PLCB2(5), PRL(4), TRH(3)	3137803	19	11	19	11	9	1	4	2	3	0	0.874	1.000	1.000
586	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BIRC2(2), CASP8(2), CFLAR(3), MAP2K4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	7391833	27	11	27	12	8	3	7	5	4	0	0.778	1.000	1.000
587	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(2), PLA2G6(4), PTGDS(2), PTGES(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1)	4265803	21	10	21	11	10	2	4	2	3	0	0.826	1.000	1.000
588	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(3), CREB1(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), PIK3R1(2), RB1(3), RELA(3), SP1(1)	4833483	21	10	20	10	4	1	6	3	7	0	0.965	1.000	1.000
589	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(4), GPX6(1), GSR(1), GSS(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), OPLAH(3)	6247383	33	10	33	16	8	9	7	3	6	0	0.646	1.000	1.000
590	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(3), CD5(2), IL12B(1), ITGAX(3), TLR2(2), TLR4(1), TLR9(5)	5172921	22	9	22	10	9	5	2	5	1	0	0.655	1.000	1.000
591	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(4), GSS(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), PGD(1)	5021987	27	9	27	13	6	7	4	4	6	0	0.688	1.000	1.000
592	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLD2(5), PPAP2B(2), PPAP2C(1)	6493807	31	9	29	16	11	4	6	4	6	0	0.904	1.000	1.000
593	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	AKT1(3), IL4R(3), JAK1(1), JAK3(3), SHC1(2), STAT6(5)	3483486	17	9	16	11	5	4	2	2	4	0	0.956	1.000	1.000
594	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), ELK1(2), HRAS(1), IL6(1), IL6R(1), IL6ST(4), JAK1(1), JAK2(2), JAK3(3), SHC1(2), SRF(1), STAT3(2)	6002130	21	9	21	16	5	3	3	2	8	0	0.992	1.000	1.000
595	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(1), JAK2(2), JAK3(3), PIAS1(2), PIAS3(2), PTPRU(6), REG1A(2), SOAT1(1)	3895037	20	9	19	15	9	2	5	0	4	0	0.989	1.000	1.000
596	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PIAS3(2), PTPRU(6), REG1A(2), SRC(2), STAT3(2)	4304090	23	9	22	16	9	5	5	0	4	0	0.970	1.000	1.000
597	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(1), HSPA1A(1), IFNGR1(2), IKBKB(4), JAK2(2), LIN7A(1), NFKBIA(2), RB1(3), RELA(3), TNFRSF1A(2), TNFRSF1B(1), USH1C(1)	4771075	23	9	23	11	5	3	8	3	4	0	0.900	1.000	1.000
598	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP23(2), SNAP29(3), STX11(2), STX12(1), STX2(1), STX3(1), STX4(2), STX7(1), TSNARE1(1), VAMP4(1), VAMP7(1), VTI1A(2)	4703952	18	8	18	13	8	0	2	2	6	0	0.991	1.000	1.000
599	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(1), JAK1(1), JAK2(2), JAK3(3), STAT1(3), STAT3(2), STAT5A(2), TYK2(2)	5208374	18	8	18	12	7	2	4	2	3	0	0.962	1.000	1.000
600	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(1), ELK1(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(2), STAT5A(2), SYK(2)	5880709	20	8	20	11	8	4	1	2	5	0	0.836	1.000	1.000
601	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(1), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TLR4(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6573136	21	8	21	11	4	3	8	3	3	0	0.943	1.000	1.000
602	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(3), DAXX(6), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(5), TNFRSF1A(2), TNFRSF1B(1)	5148539	24	8	22	10	6	3	6	4	5	0	0.812	1.000	1.000
603	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1)	6291158	21	8	21	10	3	5	7	2	4	0	0.889	1.000	1.000
604	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(3), NR1I3(1), PTGS1(2), PTGS2(1)	1464698	11	7	10	5	8	1	0	2	0	0	0.749	1.000	1.000
605	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(4), EGFR(2), MAP3K1(3), NCOR2(5), RXRA(1), THRB(1)	4601621	16	7	16	10	1	5	5	2	3	0	0.955	1.000	1.000
606	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), PIK3R1(2), PLCG1(1), PTK2(3), PXN(1), RELA(3)	7256845	21	6	21	15	7	7	2	2	3	0	0.965	1.000	1.000
607	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(1), JAK1(1), STAT1(3), STAT2(2), TYK2(2)	3025980	11	6	11	5	4	0	4	3	0	0	0.775	1.000	1.000
608	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), GGT1(1), MARS2(2), PAPSS1(2), PAPSS2(4), SCLY(2)	3464119	13	6	13	11	4	4	2	1	2	0	0.951	1.000	1.000
609	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	MTNR1A(1), MTNR1B(3), PTGDR(2), PTGFR(2), TBXA2R(1)	3240491	9	5	9	10	2	1	5	0	1	0	0.971	1.000	1.000
610	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	10	CDK5R1(1), HRAS(1), KLK2(1), NGFR(1)	1866640	4	2	4	4	3	0	1	0	0	0	0.944	1.000	1.000
611	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL16(1), IL6(1), IL9(1)	2753138	4	2	4	3	0	2	1	1	0	0	0.838	1.000	1.000
612	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), TGM2(1)	1385991	2	2	2	2	2	0	0	0	0	0	0.893	1.000	1.000
613	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1)	1876503	2	1	2	4	1	1	0	0	0	0	0.984	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	470342	1	1	1	2	0	0	1	0	0	0	0.995	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		139470	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		420745	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
