rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	AKT1(5), AKT2(1), AKT3(1), ARRB1(1), ARRB2(1), BRAF(291), CACNA1A(2), CACNA1B(3), CACNA1C(2), CACNA1D(4), CACNA1E(5), CACNA1G(3), CACNA1H(1), CACNA1S(1), CACNA2D1(5), CACNA2D3(1), CACNA2D4(2), CACNB3(1), CACNG7(1), CDC42(1), DUSP5(1), DUSP7(1), ECSIT(2), FGF20(1), FGF5(1), FGF7(1), FGFR2(1), FLNA(1), FLNC(4), HRAS(17), IL1R1(2), JUN(1), KRAS(5), MAP2K1(1), MAP2K6(1), MAP3K1(3), MAP3K3(3), MAP3K6(1), MAP3K8(1), MAP4K4(1), MAPK10(1), MAPK8IP2(1), MAPKAPK3(1), MYC(1), NF1(2), NFATC4(3), NRAS(40), PDGFRB(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PTPRR(2), RAP1A(1), RASA1(2), RASGRF2(2), RASGRP1(1), RPS6KA1(1), RPS6KA4(1), SOS1(2), SOS2(2), TAOK2(2), TAOK3(1), TGFBR1(1), TGFBR2(1), TNFRSF1A(1), TP53(4)	210566400	459	378	114	39	20	26	60	330	23	0	<1.00e-15	<1.00e-15	<6.84e-14
2	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(291), CACNA1A(2), CRH(1), CRHR1(1), GNAS(3), GRIA1(1), GRIA2(2), GRID2(1), GRM1(3), GUCY1A3(1), HRAS(17), IGF1R(3), ITPR1(2), ITPR2(6), KRAS(5), LYN(1), MAP2K1(1), NOS1(1), NPR1(2), NRAS(40), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PPP2R1A(3), PPP2R1B(1), PPP2R2B(1), PRKG1(1), RYR1(8)	81240079	406	368	61	13	15	8	52	323	8	0	<1.00e-15	<1.00e-15	<6.84e-14
3	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY8(1), BRAF(291), CACNA1C(2), CALML6(1), CAMK2A(1), CAMK2B(1), CREBBP(1), GRIA1(1), GRIA2(2), GRIN2A(2), GRIN2B(4), GRIN2D(3), GRM1(3), HRAS(17), ITPR1(2), ITPR2(6), KRAS(5), MAP2K1(1), NRAS(40), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), RAP1A(1), RPS6KA1(1)	73321784	390	363	47	14	12	7	51	312	8	0	<1.00e-15	<1.00e-15	<6.84e-14
4	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTG1(1), AKT1(5), AKT2(1), AKT3(1), BAD(1), BRAF(291), CDC42(1), COL11A1(1), COL11A2(2), COL1A1(1), COL2A1(1), COL3A1(2), COL4A1(3), COL4A2(2), COL4A4(2), COL4A6(1), COL5A1(4), COL5A3(8), COL6A2(3), COL6A3(2), COL6A6(3), CTNNB1(2), ERBB2(1), FARP2(1), FIGF(1), FLNA(1), FLNC(4), FN1(3), FYN(1), HRAS(17), IGF1R(3), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), ITGAV(1), ITGB1(2), ITGB3(1), ITGB8(1), JUN(1), KDR(2), LAMA2(1), LAMA3(3), LAMA4(4), LAMA5(2), LAMB1(1), LAMB2(1), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), MAP2K1(1), MAPK10(1), MET(2), MYLK(4), PAK3(2), PAK7(2), PDGFRB(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PTEN(2), RAP1A(1), RAPGEF1(2), RELN(2), SHC1(1), SOS1(2), SOS2(2), SRC(2), THBS1(1), THBS2(2), THBS3(1), THBS4(1), TLN1(1), TLN2(3), TNC(1), TNN(1), TNR(3), TNXB(3), VAV2(1), VCL(2), VEGFA(1), VTN(1), VWF(1), ZYX(1)	273450375	471	354	166	55	29	34	29	351	27	1	4.12e-11	<1.00e-15	<6.84e-14
5	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(291), ERBB2(1), ERBB4(3), ETS1(2), KRAS(5), MAP2K1(1), NOTCH2(1), NOTCH3(1), NOTCH4(4), PIWIL1(1), PIWIL2(2), SOS1(2), SOS2(2)	38572470	316	301	26	11	2	4	7	300	3	0	2.66e-15	<1.00e-15	<6.84e-14
6	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(5), APC(3), BRAF(291), CAMP(1), ITPR1(2), ITPR2(6), KCNJ9(1), MAPK10(1), PHKA2(3), PIK3CA(3), PIK3CD(2), PIK3R1(2), PITX2(2), SRC(2)	39418229	324	301	34	8	7	5	2	302	8	0	<1.00e-15	<1.00e-15	<6.84e-14
7	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(5), AKT2(1), AKT3(1), BRAF(291), ITPR1(2), ITPR2(6), KCNJ9(1), PIK3CB(1), PITX2(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), SHC1(1), SOS1(2), SOS2(2), SRC(2)	43042654	321	299	31	6	8	7	3	300	3	0	<1.00e-15	<1.00e-15	<6.84e-14
8	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(5), AKT2(1), AKT3(1), BRAF(291), DDIT4(1), FIGF(1), HIF1A(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), RICTOR(1), RPS6KA1(1), RPS6KB2(1), ULK3(1), VEGFA(1)	39206098	320	296	30	10	4	6	5	297	8	0	<1.00e-15	<1.00e-15	<6.84e-14
9	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(5), HRAS(17), PIK3CA(3), PIK3R1(2), PLCG1(1), SHC1(1), SOS1(2)	11466569	31	31	14	1	2	4	14	9	2	0	0.000739	<1.00e-15	<6.84e-14
10	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(2), BRAF(291), CAMP(1), SNX13(1), SRC(2)	8121202	297	291	9	4	3	0	2	289	3	0	<1.00e-15	1.22e-15	7.52e-14
11	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ABI2(1), APC(3), APC2(1), ARHGEF4(1), ARHGEF6(1), ARHGEF7(2), ARPC1B(1), BRAF(291), CDC42(1), CHRM4(1), CHRM5(1), CYFIP1(1), EZR(1), FGD1(2), FGD3(1), FGF20(1), FGF5(1), FGF7(1), FGFR2(1), FN1(3), GSN(1), HRAS(17), IQGAP1(1), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), ITGAD(2), ITGAL(4), ITGAM(2), ITGAV(1), ITGAX(1), ITGB1(2), ITGB2(1), ITGB3(1), ITGB8(1), KRAS(5), MAP2K1(1), MYH10(4), MYH14(1), MYLK(4), NCKAP1L(1), NRAS(40), PAK3(2), PAK7(2), PDGFRB(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PIP4K2C(1), PIP5K1A(1), PPP1R12B(1), SOS1(2), SOS2(2), SSH3(1), TIAM2(4), VAV2(1), VCL(2), WASL(1)	203882723	450	376	106	36	14	25	56	337	18	0	<1.00e-15	1.67e-15	9.33e-14
12	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(291), EEF2K(1), MAP2K1(1), MAP3K8(1), RAP1A(1), RPS6KA1(1), SHC1(1), SOS1(2), SOS2(2)	21770082	302	294	14	5	2	3	2	291	4	0	<1.00e-15	1.89e-15	9.47e-14
13	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(5), BRAF(291), CAMP(1), CREBBP(1), JUN(1), MAP1B(3), MAPK10(1), MAPK8IP2(1), PIK3C2G(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), SHC1(1), SRC(2)	37909515	315	293	25	6	6	6	2	296	5	0	<1.00e-15	2.00e-15	9.47e-14
14	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(1), ACACB(1), AKT1(5), AKT2(1), AKT3(1), BAD(1), BRAF(291), CALML6(1), CBL(1), EXOC7(1), FASN(1), FLOT2(1), GYS2(1), HRAS(17), INPP5D(1), INSR(1), IRS1(3), IRS2(2), KRAS(5), LIPE(1), MAP2K1(1), MAPK10(1), NRAS(40), PCK2(1), PDE3A(1), PFKP(2), PHKA2(3), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PKLR(1), PPARGC1A(3), PPP1R3B(1), PRKAG2(1), PRKAR2A(1), PYGB(1), RAPGEF1(2), RHOQ(2), RPS6KB2(1), SHC1(1), SOS1(2), SOS2(2), SREBF1(1), TRIP10(1)	118308612	420	368	75	30	13	13	54	328	12	0	1.33e-15	2.33e-15	9.57e-14
15	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(5), ABL2(1), AKT1(5), AKT2(1), AKT3(1), BAD(1), BRAF(291), CAMK2A(1), CAMK2B(1), CBL(1), CDKN1A(1), ERBB2(1), ERBB3(3), ERBB4(3), HRAS(17), JUN(1), KRAS(5), MAP2K1(1), MAPK10(1), MYC(1), NCK1(2), NRAS(40), NRG2(1), PAK3(2), PAK7(2), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLCG1(1), RPS6KB2(1), SHC1(1), SOS1(2), SOS2(2), SRC(2), STAT5B(1)	76094436	413	363	65	17	10	12	53	322	15	1	<1.00e-15	2.33e-15	9.57e-14
16	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(5), AKT1(5), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF6(1), ARHGEF7(2), BRAF(291), CDC42(1), CDKN2A(1), FYN(1), GRB7(1), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), MAPK10(1), MAPK8IP2(1), MYLK(4), P4HB(1), PAK3(2), PAK7(2), PIK3CA(3), PIK3CB(1), PKLR(1), PLCG1(1), PTEN(2), SHC1(1), SOS1(2), SOS2(2), SRC(2), TLN1(1), TLN2(3), ZYX(1)	90144192	351	309	58	16	16	11	3	309	11	1	<1.00e-15	3.11e-15	1.20e-13
17	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(291), HRAS(17), JUN(1), MAP2K1(1), MAP2K6(1), MAP3K1(3), MAP3K3(3), MAP3K6(1), MAP3K8(1), MAP3K9(1), MAP4K4(1), MAPK10(1), MAPK4(1), MAPKAPK3(1), MEF2B(1), MYC(1), RPS6KA1(1), RPS6KA4(1), RPS6KB2(1), SHC1(1), SP1(1), STAT1(1), TGFBR1(1), TRADD(1)	70035174	334	318	31	10	6	3	19	298	8	0	<1.00e-15	4.22e-15	1.53e-13
18	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(291), FYN(1), HCST(1), HLA-E(1), HRAS(17), IFNAR2(1), IFNGR1(1), ITGAL(4), ITGB2(1), KIR2DL3(1), KIR3DL1(1), KIR3DL2(1), KRAS(5), LCK(1), MAP2K1(1), NCR1(1), NFAT5(3), NFATC1(1), NFATC4(3), NRAS(40), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLCG1(1), PTK2B(2), SHC1(1), SOS1(2), SOS2(2), SYK(1), ULBP1(1), VAV2(1)	83770111	401	363	58	23	10	10	52	317	12	0	1.22e-15	5.55e-15	1.90e-13
19	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(5), GHR(1), HRAS(17), IGF1R(3), PIK3CA(3), PIK3R1(2), SHC1(1)	9830543	32	31	15	1	3	3	14	9	3	0	0.000764	7.66e-15	2.48e-13
20	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(17), PTK2B(2), SHC1(1), SOS1(2), SRC(2)	6497744	24	23	9	0	2	3	14	5	0	0	0.000373	5.66e-14	1.72e-12
21	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(5), AKT2(1), AKT3(1), CDKN1A(1), HRAS(17), MAP2K1(1), PIK3CA(3), PIK3CD(2), SHC1(1), SOS1(2)	11989474	34	34	17	3	3	5	14	8	4	0	0.00560	5.87e-14	1.72e-12
22	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(5), AKT2(1), AKT3(1), BAD(1), CDC42(1), HRAS(17), KDR(2), KRAS(5), MAP2K1(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC4(3), NRAS(40), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCG1(1), SH2D2A(2), SPHK2(1), SRC(2), VEGFA(1)	53111671	107	100	50	13	9	7	51	33	7	0	6.99e-05	6.22e-14	1.74e-12
23	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(5), AKT2(1), AKT3(1), FYN(1), HRAS(17), INPP5D(1), KRAS(5), LYN(1), MAP2K1(1), MAP2K6(1), MAPK10(1), MS4A2(1), NRAS(40), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCG1(1), SOS1(2), SOS2(2), SYK(1), VAV2(1)	53154671	101	98	44	12	5	7	49	31	9	0	0.000200	1.43e-13	3.83e-12
24	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(17), MMP2(1), RECK(1)	5573695	19	19	4	1	0	0	14	5	0	0	0.0355	1.00e-11	2.58e-10
25	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(5), HRAS(17), MEF2B(1), PIK3CA(3), PIK3R1(2), PLCG1(1), RPS6KA1(1), SHC1(1)	13952446	31	31	14	2	3	3	14	8	3	0	0.00527	3.84e-11	9.47e-10
26	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(5), AKT2(1), AKT3(1), FCGR2B(1), HRAS(17), INPP5D(1), JUN(1), KRAS(5), LILRB3(1), LYN(1), NFAT5(3), NFATC1(1), NFATC4(3), NRAS(40), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), SYK(1), VAV2(1)	54916983	97	96	40	13	6	7	49	28	7	0	0.000214	2.15e-10	5.10e-09
27	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(5), AKT2(1), AKT3(1), CBL(1), CD28(1), CD3D(1), CD4(1), CD40LG(1), CDC42(1), FYN(1), HRAS(17), JUN(1), KRAS(5), LCK(1), MAP3K8(1), NCK1(2), NFAT5(3), NFATC1(1), NFATC4(3), NRAS(40), PAK3(2), PAK7(2), PDCD1(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLCG1(1), RASGRP1(1), SOS1(2), SOS2(2), VAV2(1)	74789235	114	112	57	14	12	11	50	33	8	0	1.85e-05	1.54e-09	3.52e-08
28	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), HRAS(17), JUN(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), PLCG1(1), SHC1(1), SOS1(2)	14157293	29	29	14	3	3	1	14	7	4	0	0.0175	1.88e-08	4.14e-07
29	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(5), CDKN1A(1), HRAS(17), PIK3CA(3), PIK3R1(2), RB1(2)	14882567	30	30	13	3	1	4	14	9	2	0	0.0114	4.87e-08	1.03e-06
30	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(5), BAD(1), CDC42(1), H2AFX(1), HRAS(17), MAP2K1(1), PIK3CA(3), PIK3R1(2)	14140208	31	31	14	4	0	3	14	10	4	0	0.0437	5.44e-08	1.12e-06
31	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	HRAS(17), JUN(1), MAP2K1(1), MAP3K1(3), PLCG1(1), PTK2B(2), SHC1(1), SOS1(2), SRC(2), SYT1(1)	20995527	31	30	16	2	4	4	14	6	3	0	0.00298	1.51e-07	3.01e-06
32	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), CACNA1C(2), CACNA1D(4), CACNA1S(1), CALML6(1), CAMK2A(1), CAMK2B(1), CDC42(1), GNAS(3), HRAS(17), ITPR1(2), ITPR2(6), JUN(1), KRAS(5), MAP2K1(1), MAP2K6(1), MAP3K1(3), MAP3K3(3), MAPK10(1), MMP2(1), NRAS(40), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLD2(1), PTK2B(2), SOS1(2), SOS2(2), SRC(2)	93919280	118	105	63	12	14	10	49	37	8	0	8.77e-06	1.77e-07	3.42e-06
33	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(1), HRAS(17), PML(1), RARA(1), RB1(2), TNFRSF1A(1), TNFRSF1B(1), TP53(4)	13987761	28	27	13	3	2	1	14	5	6	0	0.0226	2.66e-07	4.96e-06
34	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), HRAS(17), IL2RA(1), IL2RG(1), JAK1(1), JUN(1), LCK(1), MAP2K1(1), SHC1(1), SOS1(2), STAT5B(1), SYK(1)	17276664	29	29	14	3	3	3	15	4	4	0	0.0124	4.21e-07	7.62e-06
35	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(5), BAD(1), HRAS(17), IGF1R(3), IRS1(3), MAP2K1(1), PIK3CA(3), PIK3R1(2), SHC1(1), SOS1(2)	13994223	38	36	21	6	2	4	14	13	5	0	0.0726	4.61e-07	8.12e-06
36	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	AKT1(5), CAMK2A(1), CAMK2B(1), GNAS(3), HRAS(17), PIK3CA(3), PIK3R1(2), PRKAR2A(1), RPS6KA1(1), SOS1(2)	21444773	36	35	19	4	2	4	15	11	4	0	0.0231	6.90e-07	1.18e-05
37	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), HRAS(17), JUN(1), MYC(1), PLCG1(1)	15143827	23	22	7	0	3	2	15	3	0	0	0.000508	7.54e-07	1.26e-05
38	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), GNAS(3), GNGT1(1), HRAS(17), MYT1(1), PRKAR2A(1), RPS6KA1(1), SRC(2)	15126686	27	27	12	3	2	0	15	9	1	0	0.0701	1.90e-06	3.08e-05
39	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	HRAS(17), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), RPS6KA1(1), SHC1(1), SOS1(2), SYK(1), VAV2(1)	23702364	29	29	14	1	2	1	15	5	6	0	0.00284	2.14e-06	3.38e-05
40	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(5), CDKN2A(1), MYC(1), PIK3CA(3), PIK3R1(2), POLR1A(1), POLR1B(2), RB1(2), TBX2(1), TP53(4), TWIST1(1)	14969711	23	23	20	1	3	2	1	4	13	0	0.0239	2.32e-06	3.58e-05
41	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), HRAS(17), MAP2K1(1)	6044013	19	19	4	4	0	0	14	3	2	0	0.394	3.05e-06	4.58e-05
42	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	GNGT1(1), HRAS(17), MAP2K1(1), PIK3C2G(1), PIK3CA(3), PIK3R1(2), PLCG1(1), PTK2B(2)	20268163	28	27	13	2	1	3	14	7	3	0	0.00808	3.77e-06	5.53e-05
43	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	ETS1(2), HDAC5(1), HRAS(17), JUN(1), NCOR2(1), RBL1(1), RBL2(1), SIN3B(1)	19110262	25	25	10	1	2	2	14	7	0	0	0.00333	4.61e-06	6.60e-05
44	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(7), ATR(3), CHEK1(1), CHEK2(4), TP53(4)	11753511	19	19	19	1	0	2	3	6	8	0	0.0527	6.23e-06	8.73e-05
45	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	GNGT1(1), HRAS(17), ITGB1(2), MAP2K1(1), PLCB1(1), SRC(2), SYK(1)	17931698	25	25	10	2	1	1	14	7	2	0	0.0177	1.15e-05	0.000157
46	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	HRAS(17), JUN(1), MAP2K1(1), MYC(1), PLCB1(1)	11460452	21	21	6	3	1	0	15	4	1	0	0.0931	1.76e-05	0.000236
47	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(5), HRAS(17), JAK2(1), JUN(1), MAP2K1(1), MAP3K1(3), MYC(1), PIK3CA(3), PIK3R1(2), SOS1(2), STAT1(1), STAT5B(1)	20708568	38	38	21	6	2	4	15	11	6	0	0.0414	2.22e-05	0.000291
48	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	HRAS(17), JUN(1), MAP2K1(1), MAP3K1(3), MEF2B(1), PTK2B(2), SHC1(1), SOS1(2), SRC(2), SYT1(1)	24720281	31	30	16	3	4	4	14	6	3	0	0.00887	2.31e-05	0.000296
49	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(5), ATM(7), BRCA1(1), CDKN1A(1), CHEK1(1), CHEK2(4), JUN(1), RAD51(1), TP53(4), TP73(3)	21947034	28	26	25	2	1	7	4	6	10	0	0.0280	2.79e-05	0.000350
50	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), HRAS(17), JAK1(1), JUN(1), MAP2K1(1), MAP3K1(3), PIK3CA(3), PIK3R1(2), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), STAT1(1)	27713391	36	36	21	4	3	2	15	10	6	0	0.0135	2.89e-05	0.000356
51	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), HRAS(17), MAP2K1(1), PTPRB(2), RASA1(2), SHC1(1), SOS1(2), SRC(2)	18355089	28	26	13	3	2	1	15	6	4	0	0.0275	6.01e-05	0.000726
52	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), FYN(1), HRAS(17), JUN(1), LCK(1), MAP2K1(1), MAP3K1(3), NFATC1(1), NFATC4(3), PIK3CA(3), PIK3R1(2), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), SYT1(1)	35358039	41	41	26	4	6	3	16	10	6	0	0.00385	7.67e-05	0.000908
53	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(4), ATM(7), CDKN1A(1), RB1(2), TP53(4)	13321231	18	18	18	0	1	4	3	4	6	0	0.00951	8.01e-05	0.000931
54	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	FYN(1), GSN(1), HRAS(17), ITGB1(2), MAP2K1(1), MYLK(4), PIK3CA(3), PIK3R1(2), SHC1(1), SRC(2), TLN1(1)	27481313	35	33	20	4	6	1	14	8	6	0	0.0156	0.000115	0.00132
55	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	HRAS(17), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), NFATC1(1), NFATC4(3), PIK3CA(3), PIK3R1(2), PLCG1(1), SHC1(1), SOS1(2), SYK(1), SYT1(1)	31834326	38	38	23	4	5	3	15	9	6	0	0.00562	0.000134	0.00150
56	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(5), AKT2(1), AKT3(1), PIK3CA(3), PIK3CD(2), PTEN(2), PTK2B(2), RBL2(1), SHC1(1), SOS1(2)	15040750	20	20	18	2	3	7	0	6	3	1	0.0459	0.000148	0.00163
57	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), HRAS(17), IGF1R(3), IRS1(3), JUN(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), RASA1(2), SHC1(1), SOS1(2)	18370968	36	34	21	6	3	1	15	12	5	0	0.0816	0.000217	0.00235
58	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(5), MAP2K1(1), MAP2K6(1), MAP3K1(3), PIK3CA(3), PIK3R1(2), RB1(2), SP1(1)	14305335	18	18	16	1	1	4	1	7	5	0	0.0575	0.000257	0.00273
59	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	GNAS(3), GNGT1(1), HRAS(17), MAP2K1(1), PIK3C2G(1), PLCB1(1), PPP1R12B(1)	18409872	25	25	10	3	1	2	14	7	1	0	0.0510	0.000271	0.00283
60	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(5), AKT2(1), AKT3(1), BAD(1), CDKN2A(1), IARS(3), IGFBP1(1), INPP5D(1), PIK3CA(3), PPP1R13B(1), PTEN(2), RPS6KA1(1), SHC1(1), SOS1(2), SOS2(2), YWHAE(1), YWHAG(1)	26591031	28	28	26	2	2	8	1	9	7	1	0.0156	0.000283	0.00291
61	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	FPR1(1), GNGT1(1), HRAS(17), MAP2K1(1), MAP2K6(1), MAP3K1(3), NFATC1(1), NFATC4(3), PIK3C2G(1), PLCB1(1), SYT1(1)	28206723	31	31	16	3	2	3	14	9	3	0	0.0116	0.000306	0.00309
62	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	GNAS(3), GNGT1(1), HRAS(17), IGF1R(3), ITGB1(2), MAP2K1(1), MYC(1), PTPRR(2), RPS6KA1(1), SHC1(1), SOS1(2), SRC(2)	24440978	36	36	21	5	5	3	15	10	3	0	0.0419	0.000330	0.00327
63	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	HRAS(17), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), NFATC1(1), NFATC4(3), PLCG1(1), SHC1(1), SOS1(2), SYK(1), SYT1(1)	28295735	33	33	18	4	5	3	15	6	4	0	0.0119	0.000390	0.00382
64	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(7), ATR(3), BRCA1(1), BRCA2(3), CHEK1(1), CHEK2(4), FANCC(1), FANCD2(3), FANCF(1), FANCG(2), RAD17(2), RAD51(1), TP53(4), TREX1(1)	32415292	34	32	33	3	0	6	7	10	11	0	0.0182	0.000424	0.00408
65	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	AKT1(5), ATM(7), CDKN1A(1), FHL2(1), HIF1A(1), TP53(4)	15314505	19	18	17	1	0	5	3	6	5	0	0.0317	0.000445	0.00422
66	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), HRAS(17), MAP2K6(1), MAP3K1(3), MAP3K9(1), MEF2B(1), MYC(1), SHC1(1), STAT1(1), TGFBR1(1), TRADD(1)	27054992	29	29	14	3	2	0	16	8	3	0	0.0261	0.000662	0.00618
67	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), HRAS(17), JAK2(1), MAP2K1(1), SHC1(1), SOS1(2), STAT5B(1)	13019436	26	26	11	5	2	2	14	5	3	0	0.144	0.000760	0.00699
68	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), HRAS(17), JAK1(1), JUN(1), MAP2K1(1), MAP3K1(3), PIK3CA(3), PIK3R1(2), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), STAT1(1)	25829435	36	36	21	5	3	2	15	10	6	0	0.0291	0.000898	0.00814
69	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), HRAS(17), INSR(1), IRS1(3), JUN(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), RASA1(2), SHC1(1), SOS1(2)	18883770	34	33	19	6	2	1	15	11	5	0	0.0891	0.00108	0.00963
70	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(7), CHEK1(1), MYT1(1), RB1(2), TP53(4), WEE1(1)	12935159	16	15	16	1	1	3	2	4	6	0	0.0948	0.00114	0.0100
71	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), HRAS(17), JAK1(1), JAK2(1), JUN(1), MAP2K1(1), SHC1(1), SOS1(2)	17650345	25	25	10	4	3	2	14	4	2	0	0.0579	0.00125	0.0108
72	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), HRAS(17), JAK2(1), JUN(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), STAT1(1), STAT5B(1), THPO(2)	22088924	36	36	21	6	4	1	15	11	5	0	0.0698	0.00132	0.0113
73	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B4(1), EIF2S2(1), FLT4(1), HIF1A(1), HRAS(17), KDR(2), PIK3CA(3), PIK3R1(2), PLCG1(1), SHC1(1)	25018382	30	30	15	4	3	1	16	8	2	0	0.0297	0.00142	0.0119
74	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	GNAS(3), GNGT1(1), HRAS(17), JUN(1), MAP2K1(1), NFATC1(1), NFATC4(3), PLCG1(1), PRKAR2A(1), SYT1(1)	25842827	30	30	15	4	5	2	15	7	1	0	0.0290	0.00150	0.0125
75	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(5), ITGB1(2), PIK3CA(3), PIK3R1(2), PTEN(2), SHC1(1), SOS1(2)	14200971	17	16	15	1	1	5	0	8	2	1	0.0519	0.00161	0.0132
76	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), SULT1E1(1), SULT2A1(1), SUOX(3)	4511431	7	7	7	0	1	1	0	1	4	0	0.176	0.00167	0.0136
77	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), HRAS(17), ITGB1(2), JUN(1), MAP2K1(1), MET(2), PIK3CA(3), PIK3R1(2), PTEN(2), PTK2B(2), RAP1A(1), RASA1(2), SOS1(2), SRC(2)	32562202	40	36	25	5	2	5	16	13	3	1	0.0125	0.00181	0.0145
78	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(5), PIK3CA(3), PIK3R1(2), PLCB1(1), PLCG1(1)	9454026	12	12	10	1	1	3	0	6	2	0	0.149	0.00261	0.0206
79	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(5), BAD(1), CBL(1), HRAS(17), IL2RA(1), IL2RG(1), IRS1(3), JAK1(1), MYC(1), PIK3CA(3), PIK3R1(2), SHC1(1), SOS1(2), STAT5B(1), SYK(1)	26642492	41	39	24	7	2	6	15	12	6	0	0.0537	0.00322	0.0251
80	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(5), BAD(1), MUSK(1), PIK3CA(3), PIK3R1(2), PTK2B(2), SRC(2), TERT(2)	12021428	18	16	16	2	3	5	0	7	3	0	0.0708	0.00349	0.0269
81	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPNS2(1), HRAS(17), ITGB1(2), MYLK(4), PRKAR2A(1), TLN1(1)	24135664	27	27	12	4	4	1	16	5	1	0	0.0470	0.00373	0.0284
82	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(1), ACTG1(1), AKT1(5), AKT2(1), AKT3(1), AMOTL1(1), ASH1L(4), CDC42(1), CGN(3), CLDN14(1), CLDN6(1), CSNK2A1(1), CTNNA3(1), CTNNB1(2), EPB41L1(1), EPB41L3(1), HCLS1(1), HRAS(17), INADL(1), JAM2(1), KRAS(5), LLGL1(1), MAGI1(1), MAGI2(1), MAGI3(1), MLLT4(1), MPDZ(2), MYH1(3), MYH10(4), MYH13(3), MYH14(1), MYH15(1), MYH2(2), MYH3(2), MYH4(1), MYH6(3), MYH7(3), MYH7B(2), MYH8(1), NRAS(40), OCLN(1), PARD3(1), PARD6B(1), PPM1J(2), PPP2R1A(3), PPP2R1B(1), PPP2R2B(1), PTEN(2), SPTAN1(1), SRC(2), TJP1(2), TJP3(1), VAPA(1), YES1(1)	143037920	144	132	84	19	13	23	53	39	15	1	4.16e-06	0.00626	0.0470
83	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(5), IGF1R(3), MYC(1), POLR2A(1), RB1(2), TEP1(3), TERT(2), TNKS(1), TP53(4), XRCC5(2)	20785610	24	23	22	3	5	6	2	5	6	0	0.0466	0.00894	0.0658
84	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(2), TAT(1)	1942591	4	4	4	0	1	0	0	2	1	0	0.493	0.00897	0.0658
85	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(1), SP1(1), TP53(4), WT1(1)	5218338	7	7	7	0	0	0	2	2	3	0	0.137	0.0109	0.0787
86	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(5), AKT2(1), AKT3(1), IARS(3), IL2RG(1), INPP5D(1), JAK1(1), JAK2(1), PIK3CA(3), PPP1R13B(1), SHC1(1), SOS1(2), SOS2(2), SRC(2), STAT6(1), TYK2(1)	27211969	27	26	25	3	4	9	1	10	3	0	0.0214	0.0111	0.0793
87	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), AKAP11(2), AKAP12(2), AKAP2(2), AKAP8(2), AKAP9(2), GNAL(2), GNB3(1), GNG5(1), GNGT1(1), HRAS(17), ITPR1(2), KRAS(5), NRAS(40), PALM2(1), PDE1A(1), PDE4B(1), PDE4D(1), PDE7B(1), PLCB3(1), PRKAR2A(1), PRKD1(3), PRKD3(1), USP5(1)	86186798	97	86	42	14	8	3	54	26	6	0	0.000646	0.0115	0.0816
88	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	AKT1(5), BAD(1), CSF2RB(3), IGF1R(3), KIT(4), PIK3CA(3), PIK3R1(2), PRKAR2A(1)	16173302	22	19	20	3	2	4	1	10	5	0	0.145	0.0124	0.0867
89	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(1), ALOX12B(2), ALOX5(1), CBR1(1), CBR3(2), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2U1(1), CYP4A11(2), DHRS4(1), EPHX2(1), GGT1(2), GPX2(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PTGES(1), PTGES2(1)	28697880	27	25	26	2	5	5	3	10	4	0	0.00835	0.0130	0.0897
90	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(7), CHEK1(1), MYT1(1), WEE1(1)	10129121	10	10	10	1	0	2	2	3	3	0	0.343	0.0131	0.0899
91	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), HRAS(17), JAK2(1), JUN(1), MAP2K1(1), PLCG1(1), SHC1(1), SOS1(2), STAT5B(1)	15906351	26	26	11	5	4	1	14	4	3	0	0.117	0.0149	0.101
92	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADRB1(1), GJA1(1), GJD2(1), GNAS(3), GRM1(3), GUCY1A3(1), HRAS(17), HTR2B(1), ITPR1(2), ITPR2(6), KRAS(5), MAP2K1(1), NPR1(2), NRAS(40), PDGFRB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PRKG1(1), SOS1(2), SOS2(2), SRC(2), TJP1(2), TUBA3C(1), TUBB2B(1)	97389424	106	100	51	16	14	5	49	34	4	0	0.000753	0.0157	0.105
93	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(1), GOT2(2), TAT(1)	3473607	5	5	5	1	2	0	0	2	1	0	0.703	0.0179	0.118
94	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGEF2(4), GBF1(5), GPLD1(1)	11957541	11	11	11	1	1	3	0	2	5	0	0.111	0.0179	0.118
95	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(5), ATM(7), ATR(3), CDKN1A(1), CDKN2A(1), RB1(2), TP53(4)	22283236	23	23	20	3	1	3	2	5	12	0	0.199	0.0220	0.143
96	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(5), BAD(1), GHR(1), PIK3CA(3), PIK3R1(2)	10379578	12	12	10	2	1	3	0	5	3	0	0.363	0.0272	0.175
97	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(1), DNMT1(2), DNMT3A(5), MARS(1), MARS2(1), MAT1A(1), MTR(1), TAT(1)	15298627	13	13	13	0	4	1	0	2	6	0	0.0269	0.0314	0.200
98	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(1), ME1(1), PC(3)	6837957	7	7	7	1	2	3	1	1	0	0	0.207	0.0318	0.200
99	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(1)	1493047	2	2	2	0	1	0	1	0	0	0	0.549	0.0329	0.205
100	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(1), HLA-DRA(1), LCK(1), PIK3CA(3), PIK3R1(2)	9437544	9	9	9	0	2	0	2	3	2	0	0.0975	0.0353	0.217
101	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(2), CNR2(2), DNMT1(2), MTNR1B(1), PTGER4(1)	8237855	9	9	9	1	4	0	0	4	1	0	0.232	0.0380	0.232
102	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	DNMT1(2), DNMT3A(5), MARS(1), MARS2(1), MAT1A(1), MTR(1)	12823101	11	11	11	0	4	1	0	1	5	0	0.0315	0.0385	0.232
103	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(1)	1746622	3	3	3	0	2	0	1	0	0	0	0.359	0.0405	0.242
104	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3D(1), CD4(1)	2367971	3	3	3	0	2	0	1	0	0	0	0.348	0.0411	0.243
105	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(5), ANGPTL2(1), DGKA(1), ITGA9(1), ITPR1(2), ITPR2(6), MAP2K1(1), PDE3A(1), PIK3C2G(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), RPS4X(1)	35803142	27	27	25	2	5	5	1	10	6	0	0.0121	0.0450	0.264
106	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(1), FYN(1), IL2RG(1), IL7R(3), JAK1(1), LCK(1), PIK3CA(3), PIK3R1(2), PTK2B(2), STAT5B(1)	20638010	16	16	16	1	0	4	2	4	6	0	0.0592	0.0455	0.264
107	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(5), APAF1(4), ATM(7), BAD(1), CASP6(1), STAT1(1), TLN1(1), TP53(4)	20182417	24	23	22	4	1	6	3	7	7	0	0.221	0.0477	0.275
108	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	GGT1(2), LCMT1(2), MARS(1), MARS2(1), MAT1A(1), METTL2B(1), PAPSS1(2), PRMT3(1), PRMT8(3)	18389027	14	14	13	1	4	2	2	4	2	0	0.0480	0.0518	0.293
109	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(5), APC(3), CAMP(1), ITPR1(2), ITPR2(6), KCNJ9(1), PITX2(2), RYR1(8)	33788580	29	28	26	3	7	7	0	12	3	0	0.00777	0.0519	0.293
110	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(7), ATR(3), BRCA1(1), CDKN1A(1), CHEK1(1), CHEK2(4), MYT1(1), PRKDC(5), RPS6KA1(1), TP53(4), WEE1(1)	30552636	29	26	29	3	0	4	4	9	12	0	0.0776	0.0560	0.313
111	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH4(1), ADH7(2)	4156497	4	4	4	1	1	0	0	3	0	0	0.641	0.0618	0.343
112	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), KERA(1)	2681829	3	3	3	0	2	0	0	0	1	0	0.399	0.0684	0.376
113	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(1), ALOX5(1), CBR1(1), CBR3(2), EPX(1), GGT1(2), MPO(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PRDX1(1), PRDX6(1), PTGES2(1), TPO(1)	20556232	19	18	19	2	3	1	2	9	4	0	0.124	0.0703	0.383
114	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(1), GOT2(2), LDHA(2)	5052282	5	5	5	1	1	0	1	3	0	0	0.552	0.0739	0.399
115	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	ITGB1(2), MAP2K1(1), PIK3CA(3), PIK3R1(2), PTK2B(2), SYK(1)	13712747	11	11	11	0	0	3	0	4	4	0	0.0541	0.0747	0.400
116	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	840008	1	1	1	0	1	0	0	0	0	0	0.717	0.0799	0.425
117	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), CAPNS2(1), FYN(1), HRAS(17), ITGB1(2), JUN(1), MAP2K1(1), PPP1R12B(1), RAP1A(1), SHC1(1), SOS1(2), SRC(2), TLN1(1), VCL(2), ZYX(1)	34654492	35	34	20	6	4	4	16	8	3	0	0.0769	0.0839	0.442
118	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(1), HRAS(17), INSR(1), IRS1(3), JAK2(1), MAP2K1(1), PIK3CA(3), PIK3R1(2), PLCG1(1), RPS6KA1(1), SHC1(1), SOS1(2), STAT5B(1)	24391447	35	34	20	8	4	1	14	10	6	0	0.248	0.0899	0.469
119	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(1), CD38(2), ENPP1(2), NADSYN1(1), NNT(1), NT5E(1), QPRT(1)	10726268	9	8	9	1	3	2	2	1	1	0	0.164	0.0937	0.485
120	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(1), CD38(2), ENPP1(2), NADK(1), NADSYN1(1), NNT(1), NT5C1B(1), NT5E(1), NUDT12(1), QPRT(1)	15864773	12	11	12	1	4	2	3	2	1	0	0.0801	0.101	0.518
121	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDKN1A(1), CDKN2A(1), TP53(4)	6265903	6	6	6	0	0	0	0	2	4	0	0.182	0.102	0.518
122	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	GGT1(2), MARS(1), MARS2(1), MAT1A(1), PAPSS1(2)	9123170	7	7	7	0	3	0	0	3	1	0	0.167	0.103	0.518
123	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	LCMT1(2), METTL2B(1), PCYT1A(1), PRMT3(1), PRMT8(3)	10402099	8	8	7	1	1	2	2	1	2	0	0.211	0.107	0.529
124	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(5), GNAS(3), GNGT1(1), PIK3CA(3), PIK3R1(2), SYT1(1)	13168390	15	15	13	3	1	4	0	8	2	0	0.394	0.108	0.529
125	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(1), CPOX(1), FECH(1), PPOX(1)	5660836	5	5	5	1	0	2	0	3	0	0	0.471	0.108	0.529
126	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), CALML6(1), CAMK2A(1), CAMK2B(1), CREB3L3(3), CREBBP(1), CTNNB1(2), DCT(1), DVL2(2), DVL3(1), FZD10(1), FZD3(1), FZD8(2), GNAS(3), HRAS(17), KIT(4), KRAS(5), LEF1(1), MAP2K1(1), MITF(1), NRAS(40), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), TCF7L1(4), TCF7L2(1), TYRP1(1), WNT11(1), WNT4(1), WNT5B(1)	80369718	108	95	53	21	15	3	51	32	7	0	0.0240	0.108	0.529
127	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(1)	2923731	3	3	3	0	2	0	1	0	0	0	0.360	0.121	0.589
128	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(4), BAD(1), CES1(1)	7955601	6	6	6	0	0	2	1	1	2	0	0.250	0.131	0.631
129	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	AOC3(1), DDC(1), EPX(1), GOT1(1), GOT2(2), HPD(1), MPO(1), PRDX1(1), PRDX6(1), TAT(1), TPO(1)	16232990	12	11	12	1	3	2	2	3	2	0	0.148	0.134	0.641
130	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	PAPSS1(2), SULT1E1(1), SULT2A1(1), SUOX(3)	6783466	7	7	7	2	1	1	0	1	4	0	0.633	0.136	0.642
131	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), GRIA2(2)	2744070	3	3	3	1	0	0	0	2	1	0	0.862	0.140	0.658
132	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(2), ATP6V0C(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), MTR(1)	13185808	9	9	9	1	0	1	2	3	3	0	0.318	0.156	0.730
133	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(3), GNGT1(1), PRKAR2A(1)	7049568	6	6	6	0	2	0	1	3	0	0	0.229	0.159	0.739
134	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), CKM(2), GPT(1), LDHA(2), NCL(1)	6589030	8	7	8	2	2	3	2	1	0	0	0.334	0.168	0.771
135	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	SDHA(1), SDHD(1), UQCRC1(2)	4882406	4	4	4	1	0	1	1	2	0	0	0.662	0.174	0.793
136	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(5), AKT2(1), AKT3(1), ITPR1(2), ITPR2(6), PHKA2(3), PIK3CB(1), PITX2(2), PLD2(1), VN1R1(2)	33036037	24	23	22	3	6	7	0	8	3	0	0.0254	0.181	0.819
137	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(1), CYP1A2(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), HSD3B7(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), RDH14(1)	17621949	12	11	12	1	3	1	2	6	0	0	0.120	0.183	0.825
138	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(2), XDH(1)	5888246	4	4	4	1	0	0	1	3	0	0	0.670	0.192	0.858
139	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB27A(2)	3099067	3	3	3	1	1	0	0	1	1	0	0.727	0.196	0.861
140	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GNT5(1), FUT1(1), FUT3(2)	5313460	4	4	4	0	0	0	2	0	2	0	0.268	0.197	0.861
141	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(2)	3043027	3	3	3	1	1	0	0	2	0	0	0.731	0.198	0.861
142	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT1(1), GOT2(2), TAT(1)	6420769	5	5	5	0	1	1	0	2	1	0	0.300	0.198	0.861
143	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(1), HLA-DRA(1), LCK(1)	6622369	5	5	5	0	3	0	1	0	1	0	0.224	0.202	0.868
144	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AKT1(5), CREBBP(1), HRAS(17), MAP2K1(1), MYH2(2), NFATC1(1), NFATC4(3), PIK3CA(3), PIK3R1(2), PRKAR2A(1), SYT1(1)	37468579	38	38	21	8	2	5	15	12	4	0	0.144	0.204	0.873
145	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(1), MPO(1), MTHFR(2), PRDX6(1), TPO(1)	8558328	6	6	6	1	1	1	0	2	2	0	0.584	0.206	0.874
146	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(5), EIF2S2(1), IGF1R(3), PIK3CA(3), PIK3R1(2), PTEN(2)	14478643	16	14	14	3	1	3	0	8	3	1	0.352	0.208	0.879
147	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(2), FBXW7(1), RB1(2)	6054181	5	4	5	0	1	1	0	1	2	0	0.204	0.214	0.895
148	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(5), APC(3), AXIN1(1), CTNNB1(2), GJA1(1), LBP(1), LEF1(1), PIK3CA(3), PIK3R1(2), TLR4(1)	22735579	20	20	18	4	1	5	2	8	4	0	0.252	0.215	0.895
149	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP68(1), SRP72(1), SRPR(2)	5561101	4	4	4	1	0	2	0	1	1	0	0.668	0.219	0.899
150	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1B(1), CDC42(1), PIK3CA(3), PIK3R1(2), WASL(1)	9866583	8	7	8	1	0	1	0	5	2	0	0.437	0.220	0.899
151	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), CPOX(1), EPRS(2), FECH(1), HCCS(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A3(2), UGT1A4(1)	20189398	12	12	12	1	1	1	3	6	1	0	0.162	0.220	0.899
152	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA2(2), GABRA3(1), GABRA6(1), SRC(2)	8792131	6	6	6	1	1	1	1	2	1	0	0.464	0.231	0.937
153	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(1), RDH14(1)	3539654	3	3	3	0	1	0	0	2	0	0	0.460	0.235	0.946
154	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA2(2), GABRA3(1), GABRA6(1)	5798483	4	4	4	0	0	1	1	1	1	0	0.376	0.237	0.948
155	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(2), GGT1(2), GPX2(1), GSTA2(1), GSTM3(1), GSTO2(2)	13318599	9	9	9	1	2	3	2	1	1	0	0.186	0.239	0.950
156	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), MPO(1), PRDX6(1), TPO(1)	6158606	4	4	4	0	1	1	0	1	1	0	0.335	0.243	0.955
157	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDKN1A(1), CHEK1(1), WEE1(1)	5029107	3	3	3	0	0	1	0	1	1	0	0.578	0.243	0.955
158	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNAS(3), GNGT1(1)	4847285	4	4	4	1	1	0	0	3	0	0	0.731	0.253	0.986
159	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	GOT1(1), GOT2(2), TAT(1)	6131167	4	4	4	0	1	0	0	2	1	0	0.486	0.254	0.986
160	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	FHL5(1), FSHR(1), GNAS(3)	7026784	5	5	5	1	1	1	0	3	0	0	0.603	0.260	1.000
161	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	LCMT1(2), METTL2B(1), PRMT3(1), PRMT8(3)	11083682	7	7	6	1	1	2	2	1	1	0	0.204	0.263	1.000
162	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(2), SP1(1)	4900478	3	3	3	0	1	1	1	0	0	0	0.333	0.269	1.000
163	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), CS(1), FH(1), IDH3B(1), OGDH(1), OGDHL(2), PC(3), PCK2(1), SDHA(1), SDHD(1)	22047713	14	13	14	0	3	4	2	5	0	0	0.00905	0.274	1.000
164	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(1), ANPEP(2), CMA1(1), ENPEP(3), LNPEP(2)	15594550	9	9	9	1	2	3	3	1	0	0	0.112	0.275	1.000
165	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT3(2)	3746845	3	3	3	0	0	0	2	0	1	0	0.543	0.276	1.000
166	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F7(1), FGA(1), PROC(1), PROS1(2)	12071186	7	7	7	1	3	0	1	3	0	0	0.349	0.282	1.000
167	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), CPT1A(3), LEPR(1), PRKAG2(1)	10666232	6	6	6	1	2	1	1	1	1	0	0.331	0.293	1.000
168	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(1), CPS1(1), GOT1(1)	5742596	3	3	3	1	2	0	0	0	0	1	0.657	0.295	1.000
169	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(3), NRG2(1)	6640624	4	4	4	0	0	0	0	3	1	0	0.384	0.299	1.000
170	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(2), MTHFD1(2), MTHFD1L(1), MTHFR(2), MTR(1)	13952447	8	8	8	1	0	1	2	2	3	0	0.365	0.302	1.000
171	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX5(1), GGT1(2), PLA2G2A(1), PLA2G6(1), PTGES(1)	11089549	7	7	7	1	2	1	1	2	1	0	0.286	0.313	1.000
172	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(1), PSAT1(1)	3576251	2	2	2	1	0	0	1	1	0	0	0.893	0.314	1.000
173	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(1), ADCY9(3), ATP6V0C(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ERO1L(1), GNAS(3), PLCG1(1), TRIM23(1)	27192948	17	16	17	2	2	1	2	10	2	0	0.227	0.316	1.000
174	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(1), PTK2B(2)	4964549	3	3	3	1	1	2	0	0	0	0	0.516	0.321	1.000
175	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD2(1), GGT1(2)	4228482	3	3	3	0	1	1	0	1	0	0	0.337	0.321	1.000
176	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(3), CDK5(1), CHN1(1), MAP3K1(3), MYLK(4), PIK3CA(3), PIK3R1(2), PPP1R12B(1), TRIO(3)	25714819	21	21	21	4	5	3	2	5	6	0	0.178	0.325	1.000
177	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GGT1(2)	4019907	3	3	3	1	1	0	1	1	0	0	0.702	0.327	1.000
178	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN2A(2), GRIN2B(4), GRIN2D(3), NOS1(1), PRKAR2A(1), SYT1(1)	18841445	12	12	12	0	2	5	1	3	1	0	0.0134	0.329	1.000
179	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), IL2RA(1), TGFBR1(1), TGFBR2(1), TGFBR3(1)	7800552	6	6	6	2	2	1	3	0	0	0	0.577	0.329	1.000
180	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	JUN(1), KEAP1(2), MAFK(1)	6523615	4	4	4	0	1	1	1	0	1	0	0.288	0.329	1.000
181	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2)	2820667	2	2	2	1	0	2	0	0	0	0	0.736	0.341	1.000
182	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), JAK1(1), STAT1(1), STAT2(1), TYK2(1)	8002296	5	5	5	0	0	2	0	3	0	0	0.215	0.341	1.000
183	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(5), AVP(1), CABIN1(1), HDAC5(1), IGF1R(3), INSR(1), MAP2K6(1), MEF2B(1), NFATC1(1), PIK3CA(3), PIK3R1(2), SYT1(1)	25641133	21	20	19	4	4	5	0	8	4	0	0.163	0.348	1.000
184	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(5), BAD(1), EEA1(1), LYN(1), PFKP(2), PLCG1(1), VAV2(1)	18421026	12	12	10	2	2	4	2	2	2	0	0.217	0.350	1.000
185	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CD3D(1), CD4(1), CREBBP(1), GNAS(3), GNGT1(1), HLA-DRA(1), LCK(1), PRKAR2A(1)	16869262	10	10	10	1	4	0	2	3	1	0	0.192	0.357	1.000
186	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CD3D(1), CD4(1), CREBBP(1), GNAS(3), GNGT1(1), HLA-DRA(1), LCK(1), PRKAR2A(1)	16869262	10	10	10	1	4	0	2	3	1	0	0.192	0.357	1.000
187	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	AFMID(1), CS(1), MTHFD1(2), MTHFD1L(1)	9881229	5	5	5	0	0	2	2	0	1	0	0.161	0.361	1.000
188	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB11(4), ABCB4(1), ABCC3(1)	10522726	6	6	6	0	1	0	2	2	1	0	0.145	0.362	1.000
189	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	1123657	1	1	1	0	0	0	0	1	0	0	0.848	0.368	1.000
190	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GFPT1(1), HEXA(1), HEXB(1), HK2(3), HK3(1), RENBP(1)	12506808	8	7	8	1	1	2	1	2	2	0	0.200	0.371	1.000
191	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), FPGT(1), GMDS(1), HK2(3), HK3(1), PFKFB3(1), PFKFB4(1), PFKP(2), PMM2(1)	17661676	12	12	12	2	2	3	3	1	3	0	0.159	0.372	1.000
192	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC2(2), BCHE(2), CES1(1), UGT1A1(1), UGT1A3(2), UGT1A4(1)	16859167	9	9	9	0	0	1	3	5	0	0	0.0887	0.373	1.000
193	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	HADHA(1), SDS(1)	3574081	2	2	2	1	1	0	0	1	0	0	0.870	0.374	1.000
194	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACSS1(1), ACSS2(1), FH(1)	9803965	5	5	5	0	1	1	0	2	1	0	0.179	0.381	1.000
195	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(4), ATM(7), ATR(3), BAI1(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(4), PPM1D(6), PTEN(2), SESN3(1), STEAP3(1), THBS1(1), TP53(4), TP73(3)	48180599	40	37	40	7	2	9	5	8	15	1	0.100	0.386	1.000
196	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(4), JUN(1)	9505475	5	5	5	1	1	2	1	0	1	0	0.456	0.389	1.000
197	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC1B(1), CDC42(1), WASL(1)	5976804	4	4	4	1	0	1	0	3	0	0	0.670	0.391	1.000
198	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC3(1), CES1(1)	4456113	2	2	2	0	0	0	1	1	0	0	0.606	0.393	1.000
199	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD4(1), ITGAL(4), ITGB2(1)	8287592	8	8	8	3	3	2	2	0	1	0	0.503	0.393	1.000
200	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	MAP2K1(1), MAP3K1(3), NCOR2(1), RARA(1), THRA(1)	12709523	7	7	7	1	1	0	0	2	4	0	0.583	0.395	1.000
201	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	MBTPS1(2), SCAP(1), SREBF1(1), SREBF2(1)	8813345	5	5	5	0	1	1	0	2	1	0	0.221	0.396	1.000
202	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(1), SPR(1)	4820892	3	3	3	1	0	2	0	1	0	0	0.542	0.397	1.000
203	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CAMK2A(1), CAMK2B(1), CDK5(1), FYN(1), GNGT1(1), HRAS(17), JAK2(1), MAP2K1(1), MYLK(4), PLCG1(1), PTK2B(2), SHC1(1), SOS1(2), STAT1(1), SYT1(1)	30636304	36	35	21	9	7	4	14	6	5	0	0.210	0.400	1.000
204	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(5), CDC42(1), IL1R1(2), JUN(1), MAP3K1(3), MAP3K3(3), MAP3K9(1), MAPK10(1), SHC1(1), TP53(4)	37131023	22	21	20	2	2	7	0	8	5	0	0.0387	0.401	1.000
205	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), JUN(1), THBS1(1)	5465209	3	3	3	1	1	1	0	0	1	0	0.700	0.406	1.000
206	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	LTB4R(2)	4407081	2	2	2	1	0	0	1	0	1	0	0.931	0.419	1.000
207	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), GRM1(3), PLCB1(1), PRKAR2A(1)	11782476	6	6	6	1	1	0	2	2	1	0	0.513	0.422	1.000
208	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(1), FH(1), OGDH(1), SDHA(1)	6934007	4	4	4	0	1	1	0	2	0	0	0.284	0.423	1.000
209	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), MET(2), SH3GLB2(1), SH3KBP1(1), SRC(2)	14310947	7	7	7	1	2	0	2	2	1	0	0.367	0.425	1.000
210	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(1), FECH(1)	5902797	3	3	3	1	0	2	0	1	0	0	0.597	0.427	1.000
211	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	JUN(1), PLCG1(1), PTK2B(2), SYT1(1)	10171065	5	5	5	0	2	3	0	0	0	0	0.0904	0.428	1.000
212	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	IFRD1(1), IL1R1(2), NR4A3(1)	7877316	4	4	4	0	0	3	0	0	1	0	0.254	0.428	1.000
213	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA4(1), PSMA6(1), PSMB7(1), PSMD14(1), RPN1(1)	9467624	5	5	5	1	1	1	0	2	1	0	0.602	0.433	1.000
214	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(1), DLAT(1), FH(1), IDH3B(1), OGDH(1), PC(3), PDHA2(1), PDHX(1), PDK3(2), SDHA(1), SDHD(1)	20955023	14	13	14	2	5	4	1	3	1	0	0.122	0.433	1.000
215	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CUL1(2), RB1(2)	6272937	4	3	4	0	1	1	0	1	1	0	0.224	0.435	1.000
216	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2)	3596413	2	2	2	1	0	2	0	0	0	0	0.743	0.445	1.000
217	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CUL1(2), RB1(2)	6302039	4	3	4	0	1	1	0	1	1	0	0.223	0.449	1.000
218	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD4(1)	4544233	2	2	2	0	2	0	0	0	0	0	0.426	0.449	1.000
219	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	DARS(1), EPRS(2), GARS(1), IARS(3), KARS(1), LARS(1), MARS(1), MARS2(1), TARS(1), WARS(1)	23630817	13	13	13	2	2	1	3	5	2	0	0.272	0.462	1.000
220	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CDKN1A(1), CDKN2A(1), CDKN2C(1), RB1(2), RBL1(1)	11865627	6	6	6	0	1	3	0	1	1	0	0.104	0.468	1.000
221	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(1), PTPRU(1), STAT1(1), STAT2(1), TYK2(1)	9233365	5	5	5	0	0	2	0	2	1	0	0.198	0.468	1.000
222	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(1)	1644950	1	1	1	0	0	0	0	1	0	0	0.836	0.474	1.000
223	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), NFATC1(1), NFATC4(3), PLCG1(1), SP1(1), SYT1(1)	15480236	8	8	8	1	3	2	1	2	0	0	0.189	0.476	1.000
224	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	AOC3(1), DDC(1), EPX(1), ESCO2(2), GOT1(1), GOT2(2), HPD(1), MPO(1), PRDX6(1), TAT(1), TPO(1)	25250378	13	12	13	0	3	2	2	3	3	0	0.0354	0.479	1.000
225	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	ETS1(2), HRAS(17), JUN(1), MAP2K1(1), MAP2K6(1), MAP3K1(3), SP1(1), TNFRSF1A(1), TNFRSF1B(1)	36201891	28	28	13	5	3	0	15	7	3	0	0.121	0.481	1.000
226	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CD4(1), HLA-DRA(1)	3936264	2	2	2	0	2	0	0	0	0	0	0.441	0.486	1.000
227	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC1B(1), NCK1(2), PIR(1), WASL(1)	11215707	6	6	6	1	1	2	1	2	0	0	0.367	0.489	1.000
228	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), EPX(1), MPO(1), PRDX1(1), PRDX6(1), TPO(1)	8698494	6	6	6	2	1	1	1	2	1	0	0.738	0.489	1.000
229	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(5), IL2RG(1), IRS1(3), JAK1(1), SHC1(1), STAT6(1)	10919487	12	12	10	4	1	5	0	6	0	0	0.532	0.500	1.000
230	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADH(1), HADHA(1), PPT2(1)	6277559	3	3	3	1	1	0	0	2	0	0	0.802	0.505	1.000
231	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1B(1), ADH4(1), ADH7(2), AOC3(1), AOX1(1), DCT(1), DDC(1), GOT1(1), GOT2(2), HGD(1), HPD(1), TAT(1), TPO(1)	23409626	15	14	15	3	4	2	2	6	1	0	0.327	0.506	1.000
232	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(2), GGT1(2), GPX2(1), GSTA2(1), GSTM3(1), GSTO2(2), OPLAH(1)	16153349	10	10	10	2	2	3	2	1	2	0	0.270	0.509	1.000
233	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), MPO(1), PRDX1(1), PRDX6(1), TPO(1)	7106918	5	5	5	2	1	1	1	1	1	0	0.835	0.509	1.000
234	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(1)	3944908	2	2	2	1	0	0	0	2	0	0	0.853	0.510	1.000
235	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(2)	5301407	2	2	2	0	1	0	0	1	0	0	0.572	0.512	1.000
236	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	CS(1), MTHFD1(2), MTHFD1L(1)	9436114	4	4	4	0	0	2	1	0	1	0	0.232	0.512	1.000
237	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA4(1), PSMA6(1), PSMB7(1)	6434195	3	3	3	0	1	1	0	1	0	0	0.378	0.517	1.000
238	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(1), KARS(1)	5121422	2	2	2	1	1	0	0	1	0	0	0.826	0.533	1.000
239	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), IL11(1)	4464837	2	2	2	0	1	0	0	0	1	0	0.651	0.537	1.000
240	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), XYLT2(1)	4860934	2	2	2	1	0	0	0	1	1	0	0.756	0.540	1.000
241	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), XYLT2(1)	4860934	2	2	2	1	0	0	0	1	1	0	0.756	0.540	1.000
242	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(5), AKT2(1), AKT3(1), ANGPTL2(1), ARHGAP4(3), ARHGEF11(1), CDC42(1), GDI1(1), GDI2(1), ITPR1(2), ITPR2(6), MYLK(4), PAK3(2), PAK7(2), PIK3CA(3), PIK3CD(2), PIK3CG(1), PIK3R1(2), PITX2(2), PPP1R13B(1), PTEN(2), RPS4X(1), WASL(1)	51748712	46	43	44	8	10	7	2	19	7	1	0.0270	0.541	1.000
243	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(1)	2892339	1	1	1	0	0	1	0	0	0	0	0.624	0.544	1.000
244	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(5), ABLIM2(1), CDC42(1), CDK5(1), DCC(2), DPYSL5(2), EPHA4(1), EPHA6(2), EPHB1(2), EPHB6(1), FYN(1), HRAS(17), ITGB1(2), KRAS(5), LRRC4C(2), MET(2), NCK1(2), NFAT5(3), NFATC1(1), NFATC4(3), NGEF(3), NRAS(40), NRP1(2), NTN4(1), PAK3(2), PAK7(2), PLXNA2(1), PLXNA3(1), PLXNB1(3), PLXNB2(1), PLXNB3(2), PLXNC1(2), RASA1(2), ROBO2(2), SEMA3A(1), SEMA4B(1), SEMA5B(1), SEMA6A(1), SEMA6B(1), SEMA6C(1), SEMA7A(3), SLIT1(1), SLIT2(2), SLIT3(1), SRGAP1(1), UNC5A(2), UNC5B(1), UNC5C(1), UNC5D(1)	145788731	139	126	81	25	13	16	57	43	10	0	0.000846	0.546	1.000
245	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1)	3621752	1	1	1	0	0	0	0	0	1	0	0.826	0.549	1.000
246	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	GOT1(1), GOT2(2), LDHA(2), SDS(1)	9242361	6	6	6	2	2	0	1	3	0	0	0.632	0.552	1.000
247	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), ITGAL(4), ITGB2(1)	7903520	7	7	7	3	2	2	2	0	1	0	0.595	0.554	1.000
248	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	KARS(1)	3474696	1	1	1	1	1	0	0	0	0	0	0.904	0.555	1.000
249	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLE(1), POLL(1), POLQ(2)	12337124	6	6	6	1	1	2	0	2	1	0	0.293	0.559	1.000
250	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(5), EIF4G1(1), EIF4G2(1), EIF4G3(1), PIK3CA(3), PIK3R1(2), PTEN(2)	20352875	15	14	13	3	0	4	2	6	2	1	0.296	0.560	1.000
251	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1)	2244019	1	1	1	0	1	0	0	0	0	0	0.686	0.575	1.000
252	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	TNFRSF1A(1), TNFRSF1B(1), TRADD(1)	6161617	3	3	3	1	1	0	0	1	1	0	0.787	0.585	1.000
253	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR24(1), MVD(1), SQLE(1), TM7SF2(2)	14174312	6	6	6	1	2	0	1	1	2	0	0.442	0.587	1.000
254	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK1(1), JAK2(1), PLA2G2A(1), PTPRU(1), STAT1(1)	8440008	6	6	6	2	1	1	1	2	1	0	0.647	0.589	1.000
255	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	JUN(1), MAP3K1(3), TNFRSF9(1), TNFSF9(1)	14213994	6	6	6	1	2	0	0	1	3	0	0.561	0.592	1.000
256	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(4), CASP6(1), JUN(1), MAP3K1(3), MAPK10(1), MYC(1), TNFRSF1A(1), TNFRSF1B(1), TP53(4), TRADD(1), TRAF1(1)	27557223	19	19	19	4	2	2	2	6	7	0	0.391	0.593	1.000
257	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(1), PCYT1A(1), PDHA2(1)	5153896	3	3	3	2	1	0	0	0	2	0	0.913	0.619	1.000
258	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	2297706	1	1	1	0	0	0	0	0	1	0	0.627	0.620	1.000
259	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1B(1), ADH4(1), ADH7(2), AKR1C3(2), CYP1A2(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), GSTA2(1), GSTM3(1), GSTO2(2), UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2)	42215502	23	22	23	3	2	5	5	10	1	0	0.0632	0.621	1.000
260	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	ERBB3(3)	7592833	3	3	3	0	0	2	1	0	0	0	0.294	0.626	1.000
261	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	LPL(1)	3931077	1	1	1	0	0	1	0	0	0	0	0.618	0.630	1.000
262	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ASL(1), CKM(2), CPS1(1)	12932520	5	5	5	1	2	2	0	0	0	1	0.330	0.631	1.000
263	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(1), EEF2K(1), EIF1AX(8), EIF2AK2(1), EIF2B4(1), EIF2S2(1), EIF4G1(1), EIF4G3(1), ETF1(2), PABPC1(1), PABPC3(1)	32195218	19	18	18	3	1	6	2	7	2	1	0.138	0.632	1.000
264	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1)	2267484	1	1	1	1	0	0	0	1	0	0	0.952	0.637	1.000
265	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	HADHA(1), SDS(1)	5760037	2	2	2	1	1	0	0	1	0	0	0.871	0.640	1.000
266	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	PTPRA(1), SRC(2)	6789138	3	3	3	0	2	0	0	1	0	0	0.388	0.642	1.000
267	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYS(2), ENPP1(2), PPCS(1)	10263288	6	6	5	3	1	1	0	0	4	0	0.923	0.644	1.000
268	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	HADHA(1), SDS(1)	6170592	2	2	2	1	1	0	0	1	0	0	0.869	0.649	1.000
269	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOB(1), FPGT(1), FUK(1), GMDS(1), HK2(3), HK3(1), HSD3B7(1), PFKFB3(1), PFKFB4(1), PFKP(2), PGM2(1), PMM2(1), RDH14(1)	27430811	16	16	16	3	3	3	5	2	3	0	0.151	0.650	1.000
270	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	PLA2G2A(1), PLA2G5(2), PLA2G6(1)	7468364	4	3	4	0	1	0	1	2	0	0	0.356	0.651	1.000
271	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1B(1), ADH4(1), ADH7(2), AOC3(1), AOX1(1), DCT(1), DDC(1), ESCO2(2), GOT1(1), GOT2(2), HGD(1), HPD(1), LCMT1(2), METTL2B(1), PRMT3(1), PRMT8(3), TAT(1), TPO(1), TYRP1(1)	43862759	25	24	24	4	6	4	5	7	3	0	0.0892	0.653	1.000
272	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3D(1), ITGAL(4), ITGB2(1)	6460718	6	6	6	3	2	2	1	0	1	0	0.651	0.655	1.000
273	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(1)	2975128	1	1	1	0	0	1	0	0	0	0	0.668	0.656	1.000
274	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ARRB2(1), CALML6(1), CAMK2A(1), CAMK2B(1), CLCA4(1), CNGA4(1), CNGB1(4), GNAL(2), GUCA1A(1), PRKG1(1)	22494515	15	15	15	4	2	4	2	3	4	0	0.383	0.658	1.000
275	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(3), HK3(1), ISYNA1(2)	8605392	6	6	6	3	1	1	0	1	3	0	0.838	0.658	1.000
276	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	EIF2S2(1), TP53(4)	7185335	5	5	5	2	0	0	0	2	3	0	0.778	0.659	1.000
277	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(1), CREBBP(1)	7807571	3	3	3	0	0	1	0	0	2	0	0.516	0.663	1.000
278	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ITGAL(4), ITGAM(2), ITGB1(2), ITGB2(1)	11705271	10	10	10	4	3	4	1	1	1	0	0.539	0.665	1.000
279	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(5), AKT2(1), AKT3(1), CDKN2A(1), FLOT2(1), ITPR1(2), ITPR2(6), LYN(1), PIK3CA(3), PITX2(2), PPP1R13B(1), PTEN(2), RPS6KA1(1), SYK(1)	40646088	28	28	26	5	5	5	2	7	8	1	0.0907	0.669	1.000
280	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(1), CYP11B1(2), HSD11B2(1), HSD17B3(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A3(2), UGT1A4(1)	20184524	12	12	12	3	1	2	5	2	2	0	0.276	0.671	1.000
281	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2), XYLB(1)	20050121	9	8	9	1	0	2	3	3	1	0	0.179	0.674	1.000
282	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT2(1), AGPS(1), CDS2(1), CHAT(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), GNPAT(4), LGALS13(1), PCYT1A(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLCB2(1), PLCG1(1), PPAP2C(1)	36747616	27	26	27	5	6	4	4	5	8	0	0.168	0.675	1.000
283	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH5A1(1), CAD(1), CPS1(1), EPRS(2), GAD2(1), GFPT1(1), GMPS(1), GOT1(1), GOT2(2), GPT(1), NADSYN1(1), PPAT(1)	24427778	15	14	15	3	3	6	1	3	1	1	0.193	0.675	1.000
284	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	HIF1A(1), JUN(1), LDHA(2), P4HB(1)	12472960	5	5	5	0	1	0	2	2	0	0	0.222	0.677	1.000
285	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1R(2)	4845221	2	2	2	1	0	0	0	1	1	0	0.742	0.677	1.000
286	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(5), AKT2(1), AKT3(1), BAD(1), IRS1(3), IRS2(2), JAK1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(1), SOS1(2), SOS2(2), STAT6(1)	26960729	28	28	26	7	3	8	1	12	4	0	0.308	0.681	1.000
287	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHSY1(1), DSE(1), XYLT2(1)	10369141	4	4	4	1	1	1	0	1	1	0	0.489	0.687	1.000
288	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	HMGB1(2)	6386501	2	2	2	3	0	0	0	0	2	0	1.000	0.690	1.000
289	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(1), C2(2), C3(1), C5(1), C6(1), C7(2)	12823924	9	9	9	3	2	0	0	4	3	0	0.782	0.690	1.000
290	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRB1(1), CHRM4(1), CHRM5(1), DRD4(2), DRD5(3), HRH1(1), HRH2(1), HTR2B(1), HTR5A(1)	18962620	13	12	13	3	2	3	1	7	0	0	0.269	0.692	1.000
291	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	CS(1), FH(1), IDH3B(1), PC(3), SDHA(1)	15209999	7	6	7	0	2	2	1	2	0	0	0.0848	0.702	1.000
292	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), MAP2K1(1), MAP3K1(3), NSMAF(1), TNFRSF1A(1), TRADD(1)	15123714	8	8	8	2	1	0	0	2	5	0	0.791	0.702	1.000
293	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNGT1(1), PLCB1(1)	5271817	2	2	2	0	0	0	0	2	0	0	0.699	0.702	1.000
294	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), TF(2)	9417302	3	3	3	1	1	1	1	0	0	0	0.579	0.709	1.000
295	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	GNGT1(1), PIK3CA(3), PIK3R1(2), PLCB1(1), PPP1R12B(1), PTK2B(2)	19034228	10	10	10	2	0	3	0	5	2	0	0.405	0.710	1.000
296	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CLOCK(1), CRY1(1), EIF4G2(1), GSTM3(1), HSPA8(1), NCOA4(1), PSMA4(1), PURA(1), SF3A3(1), SUMO3(3), VAPA(1)	26906139	13	13	11	2	1	3	1	4	4	0	0.353	0.710	1.000
297	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(1), ADH1B(1), ADH4(1), ADH7(2), ESCO2(2)	18403396	7	7	7	1	1	0	1	4	1	0	0.490	0.711	1.000
298	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(3), LARS(1), PDHA2(1)	7381590	6	6	6	3	1	1	1	1	2	0	0.859	0.712	1.000
299	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	CFTR(2), GNAS(3), PRKAR2A(1)	9588826	6	6	6	2	1	0	2	3	0	0	0.756	0.717	1.000
300	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	HADH(1), HADHA(1), SIRT2(1), VNN2(2)	8767621	5	5	5	2	1	1	1	1	1	0	0.796	0.718	1.000
301	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	CTNNB1(2), SRC(2), VCL(2)	14111919	6	6	6	0	1	0	2	3	0	0	0.214	0.720	1.000
302	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(1), POLR2B(1)	9941645	4	4	4	0	0	1	0	1	2	0	0.349	0.723	1.000
303	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	SQLE(1)	3094535	1	1	1	1	0	0	0	0	1	0	0.885	0.727	1.000
304	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IL1R1(2), MAP3K1(3), TLR4(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(1)	17960744	9	9	9	2	1	2	1	2	3	0	0.470	0.730	1.000
305	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ENPP1(2)	7153214	2	2	2	1	0	1	0	0	1	0	0.877	0.731	1.000
306	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), PKLR(1)	6858781	2	2	2	1	1	1	0	0	0	0	0.659	0.731	1.000
307	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	CMA1(1), COL4A1(3), COL4A2(2), COL4A3(2), COL4A4(2), COL4A5(2), COL4A6(1)	18640996	13	13	13	4	2	2	2	4	3	0	0.464	0.735	1.000
308	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ITGAL(4), ITGAM(2), ITGB2(1)	7611878	8	8	8	4	3	3	1	0	1	0	0.651	0.737	1.000
309	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1)	4634726	1	1	1	0	0	0	0	0	1	0	0.838	0.740	1.000
310	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	HADHA(1)	3983338	1	1	1	1	0	0	0	1	0	0	0.972	0.740	1.000
311	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C5(1), C6(1), C7(2)	9210095	5	5	5	2	1	0	0	2	2	0	0.791	0.745	1.000
312	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(1), ESR1(1), SRC(2)	10867105	4	4	4	1	1	0	0	1	2	0	0.570	0.753	1.000
313	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH4(1), ADH7(2), ALDH2(1)	9765565	5	5	5	2	1	0	0	4	0	0	0.767	0.758	1.000
314	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11A1(2), CYP11B1(2), HSD11B2(1)	6813188	6	6	6	3	1	3	0	2	0	0	0.649	0.760	1.000
315	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11A1(2), CYP11B1(2), HSD11B2(1)	6813188	6	6	6	3	1	3	0	2	0	0	0.649	0.760	1.000
316	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), IFNGR1(1), IL12RB2(1), IL2RA(1)	9320561	5	5	5	2	3	0	1	1	0	0	0.590	0.761	1.000
317	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ALPI(1), ALPP(1), CYP19A1(1), CYP1A2(1), CYP2A13(2), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1)	21632956	10	10	10	2	1	2	2	5	0	0	0.299	0.762	1.000
318	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC2(1), APOBEC3G(1)	5395790	3	3	3	2	0	1	0	1	1	0	0.921	0.763	1.000
319	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), JAK1(1), JAK2(1), STAT1(1)	6033137	4	4	4	2	1	1	0	2	0	0	0.800	0.765	1.000
320	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	HSD3B7(1), RDH14(1)	6635917	2	2	2	0	1	0	0	1	0	0	0.555	0.767	1.000
321	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(1), CPOX(1), EPRS(2), FECH(1), FTH1(1), HCCS(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2)	31136109	18	17	18	3	1	4	3	8	2	0	0.208	0.767	1.000
322	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT6(2), AGPS(1), ENPP2(3), ENPP6(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLD2(1), PPAP2C(1)	17085302	14	12	14	4	5	1	2	5	1	0	0.449	0.775	1.000
323	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	FGA(1), PLG(1), SERPINB2(1)	9888099	3	3	3	0	0	0	1	1	1	0	0.401	0.778	1.000
324	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UGT1A1(1), UGT1A3(2), UGT1A4(1)	12930046	4	4	4	0	0	0	3	1	0	0	0.286	0.781	1.000
325	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ASL(1), CKM(2), CPS1(1), EPRS(2), GOT1(1), GOT2(2), NOS1(1)	26490068	10	10	10	1	3	1	0	4	1	1	0.202	0.787	1.000
326	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1)	4483684	1	1	1	0	1	0	0	0	0	0	0.664	0.788	1.000
327	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNAS(3), GNGT1(1), PRKAG2(1), PRKAR2A(1)	11271996	6	6	6	2	1	1	1	3	0	0	0.658	0.790	1.000
328	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(2), HSD11B2(1)	5099606	3	3	3	2	0	2	0	1	0	0	0.782	0.794	1.000
329	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY1(1)	6275462	2	2	2	1	0	1	0	0	1	0	0.901	0.796	1.000
330	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	HEXA(1), HEXB(1), LCT(1)	10635132	3	3	3	1	1	0	1	0	1	0	0.612	0.800	1.000
331	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1)	3647302	1	1	1	0	0	0	0	1	0	0	0.836	0.800	1.000
332	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	MVD(1), SQLE(1)	8103444	2	2	2	0	1	0	0	0	1	0	0.412	0.804	1.000
333	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	GNGT1(1), MYLK(4), PLCB1(1), PPP1R12B(1)	15210788	7	7	7	2	3	1	0	2	1	0	0.482	0.804	1.000
334	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1B(2), POLR2A(1), POLR2B(1), POLR3B(1)	17301507	6	6	6	0	1	1	0	2	2	0	0.215	0.804	1.000
335	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), DPYS(2), ENPP1(2), PPCS(1)	12748040	6	6	5	3	1	1	0	0	4	0	0.920	0.806	1.000
336	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFS1(1), NDUFV2(1)	5114727	2	2	2	2	0	0	1	0	1	0	0.894	0.808	1.000
337	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	UBE2F(1)	4743330	1	1	1	0	0	1	0	0	0	0	0.643	0.809	1.000
338	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ITGAL(4), ITGB1(2), ITGB2(1)	8896378	8	8	8	4	1	4	1	1	1	0	0.718	0.809	1.000
339	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(1), CYP11B1(2), CYP19A1(1), HSD11B2(1), HSD17B1(1), HSD17B3(1), LCMT1(2), METTL2B(1), PRMT3(1), PRMT8(3), STS(1), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2)	37027617	25	23	24	5	2	6	7	7	3	0	0.0774	0.815	1.000
340	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(1), C2(2), C3(1), C5(1), C6(1), C7(2)	15254383	9	9	9	3	2	0	0	4	3	0	0.779	0.820	1.000
341	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	CPT1A(3), HADHA(1)	12415194	4	4	4	1	1	0	0	2	1	0	0.599	0.821	1.000
342	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	JUN(1), POLR2A(1), PRKAR2A(1)	9508864	3	3	3	0	1	1	1	0	0	0	0.294	0.823	1.000
343	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH2(1), AMDHD1(2), AOC3(1), DDC(1), LCMT1(2), METTL2B(1), PRMT3(1), PRMT8(3), PRPS1(2), UROC1(1)	29238477	15	15	14	3	4	3	3	3	2	0	0.170	0.824	1.000
344	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	JUN(1), MAP2K6(1), MAP3K1(3), PPARA(1), TLR2(1), TLR3(1), TLR4(1), TLR7(1)	27036376	10	10	10	1	1	0	2	4	3	0	0.316	0.825	1.000
345	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(2), MAP2(1), PRKAR2A(1)	13336180	4	4	4	0	0	0	3	0	1	0	0.240	0.825	1.000
346	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC3(1), CES1(1), ESCO2(2), PLA1A(1), PRDX6(1)	18657078	6	6	6	0	0	1	2	2	1	0	0.210	0.829	1.000
347	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(1), C2(2), C3(1), C5(1), C6(1), C7(2)	15628880	9	9	9	3	2	0	0	4	3	0	0.774	0.837	1.000
348	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(1), ST8SIA1(1)	4509747	3	3	3	2	0	0	3	0	0	0	0.899	0.842	1.000
349	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), FYN(1), RELN(2), VLDLR(1)	10331411	5	5	5	2	0	1	1	1	2	0	0.889	0.844	1.000
350	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	IL11(1)	6093709	1	1	1	1	0	0	0	0	1	0	1.000	0.845	1.000
351	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CTBS(1), GFPT1(1), HEXA(1), HEXB(1), HK2(3), HK3(1), NANS(1), RENBP(1)	21176778	10	9	10	2	1	2	2	3	2	0	0.286	0.847	1.000
352	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK2A(1), CAMK2B(1), CAMKK2(1), SYT1(1)	8517816	4	4	4	3	1	1	0	0	2	0	0.945	0.849	1.000
353	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), PDE1A(1), PLCB1(1), PLCB2(1)	8197779	4	4	4	2	1	0	0	2	1	0	0.742	0.852	1.000
354	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), GOT1(1), GOT2(2), GPT(1), ME1(1), PKLR(1), RPIA(1)	13299464	8	8	8	3	3	1	1	3	0	0	0.593	0.854	1.000
355	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH5A1(1), CAD(1), CPS1(1), EPRS(2), GAD2(1), GFPT1(1), GMPS(1), GOT1(1), GOT2(2), GPT(1), NADSYN1(1), PPAT(1)	29092993	15	14	15	3	3	6	1	3	1	1	0.179	0.856	1.000
356	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA4(1), PSMA6(1), PSMB7(1)	11786941	3	3	3	0	1	1	0	1	0	0	0.393	0.864	1.000
357	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(5), CDC42(1), EEF2K(1), IL1R1(2), MAP2K6(1)	24662537	10	10	8	2	0	5	0	5	0	0	0.345	0.870	1.000
358	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(5), EIF4G1(1), EIF4G2(1), EIF4G3(1), GHR(1), IRS1(3), PABPC1(1), PIK3CA(3), PIK3R1(2), PTEN(2)	20756642	20	19	18	5	1	4	3	9	2	1	0.449	0.870	1.000
359	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	MVD(1), SQLE(1)	9664755	2	2	2	0	1	0	0	0	1	0	0.431	0.870	1.000
360	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	XDH(1)	7324689	1	1	1	1	0	0	0	1	0	0	0.933	0.874	1.000
361	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(1), CRHR1(1), ELTD1(1), EMR2(1), GLP2R(2), LPHN2(1), LPHN3(2)	19600742	10	10	10	3	4	1	2	2	1	0	0.450	0.883	1.000
362	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(1), DDC(1), GAD2(1)	10633084	3	3	3	0	1	1	0	0	1	0	0.316	0.886	1.000
363	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	AKT1(5), GNGT1(1), ITGAV(1), ITGB3(1), PIK3CA(3), PIK3R1(2), PLCB1(1), SMPD2(1), SRC(2)	20217647	17	15	15	5	1	4	0	10	2	0	0.514	0.886	1.000
364	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), AKT1(5), ANGPTL2(1), CDC42(1), FLNA(1), FLNC(4), FSCN1(1), GDI1(1), GDI2(1), MYH2(2), MYLK(4), PAK3(2), PAK7(2), RPS4X(1), WASL(1)	35316442	28	28	26	7	5	6	2	13	2	0	0.199	0.886	1.000
365	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNGR1(1), JAK2(1), RB1(2), TNFRSF1A(1), TNFRSF1B(1), TP53(4), WT1(1)	13363330	11	10	11	4	3	1	0	4	3	0	0.604	0.888	1.000
366	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	DARS(1), EPRS(2), FARSA(1), GARS(1), IARS(3), KARS(1), LARS(1), MARS(1), MARS2(1), TARS(1), VARS(1), VARS2(1), WARS(1)	40022460	16	16	16	2	3	2	3	5	3	0	0.163	0.889	1.000
367	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	MAP3K1(3), TNFRSF1B(1), TRAF1(1)	16548975	5	5	5	1	0	0	0	3	2	0	0.694	0.890	1.000
368	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	HEXA(1), HEXB(1), LCT(1), SPAM1(1)	15126918	4	4	4	1	1	0	1	1	1	0	0.569	0.890	1.000
369	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT3(1), B3GNT5(1), FUT1(1), FUT3(2), ST8SIA1(1)	11918832	7	7	7	3	0	0	4	1	2	0	0.743	0.890	1.000
370	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(1), NCOA3(1), PRKAR2A(1), RARA(1)	15231604	4	4	4	1	0	0	2	0	2	0	0.688	0.891	1.000
371	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(1), ITPR1(2), ITPR2(6), NFAT5(3), TF(2)	26337316	15	14	15	4	6	2	0	3	4	0	0.315	0.896	1.000
372	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1)	5806248	1	1	1	1	0	0	1	0	0	0	0.929	0.896	1.000
373	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), FCGR2B(1), HLA-DRA(1), ITGAL(4), ITGB2(1)	11139018	8	8	8	4	2	2	2	1	1	0	0.738	0.907	1.000
374	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	PRKAR2A(1)	7432882	1	1	1	1	0	0	1	0	0	0	0.888	0.907	1.000
375	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(2), COL4A3(2), COL4A4(2), COL4A5(2), COL4A6(1), P4HB(1), SLC23A2(1)	18515689	14	14	14	5	2	2	1	6	3	0	0.614	0.910	1.000
376	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	JUN(1), MAP2K6(1), MAP3K1(3), TNFRSF1A(1), TRADD(1)	17742937	7	7	7	2	2	0	0	2	3	0	0.693	0.910	1.000
377	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	OAZ1(1), POLB(1), POLD1(1), RRM1(1)	9237868	4	4	4	2	2	0	0	1	1	0	0.845	0.910	1.000
378	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(1), ACACB(1), FASN(1)	11636943	3	3	3	1	2	0	0	1	0	0	0.743	0.913	1.000
379	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPNS2(1), CDK5(1)	6771346	2	2	2	3	0	0	1	0	1	0	0.998	0.915	1.000
380	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	JUNB(1), NFATC1(1), PRKAR2A(1)	8964782	3	3	3	2	1	0	1	0	1	0	0.872	0.915	1.000
381	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(3), HK3(1)	7542916	4	4	4	3	1	1	0	1	1	0	0.846	0.917	1.000
382	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	FH(1)	6566149	1	1	1	0	0	0	0	1	0	0	0.833	0.917	1.000
383	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD9(1), ADH1B(1), ADH4(1), ADH7(2), AKR1D1(1), ALDH2(1), CEL(1), HSD3B7(1), RDH14(1), SOAT1(1)	23309720	11	11	11	3	2	2	0	7	0	0	0.487	0.917	1.000
384	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	PLCB1(1)	6062656	1	1	1	0	0	0	0	1	0	0	0.843	0.918	1.000
385	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(3), CREBBP(1), MAP2K1(1), TGFBR1(1), TGFBR2(1)	18937222	7	7	7	2	0	0	2	2	3	0	0.746	0.922	1.000
386	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(3), LARS(1), PDHA2(1), VARS(1), VARS2(1)	13713780	8	8	8	3	2	1	1	1	3	0	0.782	0.923	1.000
387	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(1), ALDH2(1), AMD1(1), AOC3(1), ASL(1), CPS1(1)	21777206	6	6	6	1	1	1	1	2	0	1	0.343	0.925	1.000
388	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAPK10(1), MAPK8IP2(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), SYT1(1)	24754643	10	10	10	2	2	1	0	4	3	0	0.425	0.926	1.000
389	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(1)	7269083	1	1	1	0	0	1	0	0	0	0	0.569	0.929	1.000
390	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(4), SCAP(1), SREBF1(1), SREBF2(1)	13444273	7	7	7	3	1	3	1	1	1	0	0.756	0.929	1.000
391	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK4(1), EIF2S2(1)	8490835	2	2	2	2	0	0	0	1	1	0	0.955	0.933	1.000
392	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), HEXA(1), HEXB(1), ST8SIA1(1)	7467968	4	4	4	4	0	0	3	0	1	0	0.977	0.935	1.000
393	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(2), COL4A3(2), COL4A4(2), COL4A5(2), COL4A6(1), F10(2), F8(3), F9(1), FGA(1), PROC(1), PROS1(2)	32809566	22	22	22	6	5	2	2	8	5	0	0.356	0.935	1.000
394	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLB(1), POLD1(1), POLD3(1), POLE(1), POLE2(1), POLL(1), POLQ(2), REV1(1), REV3L(1)	29820048	10	9	10	1	1	3	0	3	3	0	0.237	0.937	1.000
395	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	MAP3K1(3)	13359934	3	3	3	1	0	0	0	1	2	0	0.826	0.940	1.000
396	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(3), ARHGAP6(1), ARHGEF11(1), ARPC1B(1), GSN(1), MYLK(4), PIP5K1A(1), PPP1R12B(1), SRC(2), TLN1(1), VCL(2)	33635020	18	18	18	4	5	3	1	4	5	0	0.181	0.943	1.000
397	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ESR1(1)	8046768	1	1	1	2	0	0	0	0	1	0	0.921	0.943	1.000
398	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CDKN2A(1)	6655295	1	1	1	0	0	0	0	0	1	0	0.676	0.945	1.000
399	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT1(1), HEXA(1), HEXB(1), ST8SIA1(1)	7926469	4	4	4	4	0	0	3	0	1	0	0.975	0.945	1.000
400	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	HEXA(1), HEXB(1), LCT(1), MAN2B1(2), MAN2C1(1), MANBA(1)	15035748	7	7	7	3	2	1	1	0	3	0	0.779	0.946	1.000
401	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH2(1)	6288109	1	1	1	1	0	0	0	1	0	0	0.940	0.949	1.000
402	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), BECN1(1), ULK3(1)	15557025	3	3	3	1	1	0	0	1	1	0	0.753	0.952	1.000
403	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), HIF1A(1), JAK2(1)	9319039	3	3	3	2	1	0	1	1	0	0	0.850	0.952	1.000
404	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(4), MAPKAPK3(1)	8360146	6	6	6	4	1	2	1	1	1	0	0.856	0.955	1.000
405	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(2), FYN(1), ITGB1(2), LYN(1)	11662640	8	8	8	4	0	3	1	3	1	0	0.802	0.957	1.000
406	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1B(1), GLI2(3), GLI3(1), PRKAR2A(1), SUFU(1)	12264258	7	7	7	5	3	1	1	0	2	0	0.769	0.959	1.000
407	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK1(1), JAK2(1), PIAS3(1), PTPRU(1), SRC(2)	11229393	6	6	6	3	2	1	1	1	1	0	0.799	0.959	1.000
408	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(3), AXIN1(1), CREBBP(1), CTNNB1(2), LEF1(1), PITX2(2), TRRAP(3)	24482489	13	13	13	4	1	1	2	6	3	0	0.632	0.960	1.000
409	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), GOT1(1), GOT2(2), GPT(1), ME1(1), PKLR(1), RPIA(1), TKTL2(1)	14874982	9	9	9	4	3	1	1	4	0	0	0.693	0.960	1.000
410	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	GPRC5B(2), GPRC5D(1), GRM1(3), GRM2(1), GRM4(2)	15493175	9	8	9	4	1	3	1	3	1	0	0.694	0.962	1.000
411	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), HLA-DRA(1), IL11(1)	9789059	3	3	3	5	2	0	0	0	1	0	0.993	0.962	1.000
412	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	GNAS(3), PRKAR2A(1)	10857093	4	4	4	2	1	0	1	2	0	0	0.832	0.963	1.000
413	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IL1R1(2), IRAK2(1), IRAK3(1), JUN(1), MAP2K6(1), MAP3K1(3)	21918869	9	9	9	3	2	2	1	2	2	0	0.617	0.964	1.000
414	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	JUN(1), MAP3K3(3), TNFRSF1A(1), TNFRSF1B(1), TRADD(1)	20044085	7	7	7	2	2	2	0	2	1	0	0.523	0.966	1.000
415	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD5(2), ITGAX(1), TLR2(1), TLR4(1), TLR7(1)	13732064	8	8	8	4	1	2	2	2	1	0	0.711	0.967	1.000
416	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(5), AKT2(1), AKT3(1), ARHGEF11(1), CDC42(1), MAP3K1(3), PHKA2(3), PIK3CB(1), PLD2(1)	36114268	17	17	15	4	2	5	0	6	4	0	0.359	0.967	1.000
417	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AFMID(1), ALDH2(1), AOC3(1), AOX1(1), ASMT(1), CYP1A2(1), DDC(1), HAAO(1), HADH(1), HADHA(1), LCMT1(2), LNX1(1), METTL2B(1), NFX1(1), OGDH(1), OGDHL(2), PRMT3(1), PRMT8(3), TDO2(2), TPH2(1), WARS(1)	44695625	26	26	25	6	4	2	7	11	2	0	0.251	0.968	1.000
418	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(4), BAD(1), CASP6(1), HELLS(1), IRF1(1), IRF3(1), IRF4(1), IRF5(2), JUN(1), MAP3K1(3), MAPK10(1), MYC(1), TNFRSF1A(1), TNFRSF1B(1), TP53(4), TP73(3), TRADD(1), TRAF1(1)	42333345	29	28	29	7	2	6	4	8	9	0	0.294	0.968	1.000
419	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(1), PIGO(1), PIGS(1), PIGZ(2)	17475844	5	5	5	2	0	3	1	0	1	0	0.638	0.969	1.000
420	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1)	6858288	1	1	1	1	1	0	0	0	0	0	0.849	0.969	1.000
421	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ALDH2(1), AOC3(1), DPYS(2), GAD2(1), HADHA(1), MLYCD(1)	19923352	8	8	7	3	0	2	1	3	2	0	0.799	0.971	1.000
422	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	ESCO2(2)	12214026	2	2	2	0	0	0	1	0	1	0	0.680	0.971	1.000
423	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(5), AKT2(1), AKT3(1), BAD(1), LYN(1), MAP2K1(1), NFAT5(3), PIK3CA(3), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(1), SOS1(2), SOS2(2), SYK(1)	38858048	27	26	25	7	3	6	2	9	7	0	0.304	0.972	1.000
424	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(1), ALDH2(1), ALDH5A1(1), BDH1(2), GAD2(1), HADH(1), HADHA(1), HSD3B7(1), PDHA2(1), PLA1A(1), PRDX6(1), RDH14(1)	29929030	14	14	14	4	4	4	0	6	0	0	0.411	0.972	1.000
425	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(1), TYK2(1)	8640570	3	3	3	2	1	1	0	1	0	0	0.830	0.973	1.000
426	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ALAS1(1), AOC3(1), DMGDH(1), GARS(1), GCAT(1), HSD3B7(1), PHGDH(1), PSAT1(1), RDH14(1), SARDH(1), SDS(1), TARS(1)	31552874	12	11	12	3	2	2	2	5	1	0	0.445	0.973	1.000
427	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(4), CASP6(1)	9907959	5	5	5	3	0	2	1	1	1	0	0.925	0.975	1.000
428	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	JUN(1), MAP3K1(3), PRKDC(5), RB1(2), SPTAN1(1), TNFRSF1A(1), TRADD(1)	28279730	14	13	14	4	3	2	1	2	6	0	0.485	0.975	1.000
429	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1)	11084440	5	5	5	3	0	1	1	2	1	0	0.895	0.976	1.000
430	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1)	11084440	5	5	5	3	0	1	1	2	1	0	0.895	0.976	1.000
431	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1)	11084440	5	5	5	3	0	1	1	2	1	0	0.895	0.976	1.000
432	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(1), PIAS3(1), PTPRU(1), SOAT1(1)	10076489	5	5	5	3	1	2	1	0	1	0	0.819	0.976	1.000
433	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(3), CAMP(1), JUN(1), MAPK10(1), MAPK8IP2(1)	21076279	7	7	7	2	3	0	0	3	1	0	0.503	0.977	1.000
434	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(1), JAK1(1), JAK2(1), STAT1(1), STAT5B(1), TYK2(1)	13551184	6	6	6	3	2	1	0	2	1	0	0.759	0.977	1.000
435	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C5(1), C6(1), C7(2), ITGAL(4), ITGB1(2), ITGB2(1), VCAM1(2)	18227339	14	14	14	7	2	3	1	5	3	0	0.832	0.977	1.000
436	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR2(1)	8169135	1	1	1	0	0	0	0	1	0	0	0.836	0.978	1.000
437	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ALPI(1), ALPP(1)	13296879	2	2	2	1	0	1	0	1	0	0	0.767	0.978	1.000
438	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10A(1), RPL12(1), RPL13A(1), RPL18A(1), RPL22L1(1), RPL36AL(1), RPL9(2), RPS2(1)	16516526	9	8	9	3	1	4	0	4	0	0	0.635	0.979	1.000
439	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR2A(1), ACVR2B(1), AMHR2(1), BMP6(2), CREBBP(1), CUL1(2), GDF6(1), ID2(1), ID4(1), INHBA(2), INHBC(1), INHBE(1), LEFTY1(1), LTBP1(4), MYC(1), NODAL(1), PITX2(2), PPP2R1A(3), PPP2R1B(1), PPP2R2B(1), RBL1(1), RBL2(1), RPS6KB2(1), SMURF2(1), SP1(1), TGFBR1(1), TGFBR2(1), THBS1(1), THBS2(2), THBS3(1), THBS4(1), ZFYVE16(1)	72886573	42	38	41	7	5	11	8	6	12	0	0.0281	0.980	1.000
440	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(1), GALNT2(1), GALNT7(1), GALNT8(1)	10649611	4	4	4	3	2	0	0	1	1	0	0.950	0.980	1.000
441	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(5), FLT4(1), KDR(2), PDE2A(1), PDE3A(1), PRKAR2A(1), PRKG1(1), RYR2(4), SYT1(1)	29656106	18	17	16	5	1	7	2	6	2	0	0.305	0.981	1.000
442	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ENPP1(2)	11077671	2	2	2	2	0	1	0	0	1	0	0.959	0.981	1.000
443	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASRGL1(1), CA13(2), CPS1(1)	15656226	4	4	4	2	0	1	1	1	0	1	0.741	0.982	1.000
444	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1)	11796147	5	5	5	3	0	1	1	2	1	0	0.895	0.982	1.000
445	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	MAP3K1(3), MYC(1), NFATC1(1), PLCG1(1), PRKAR2A(1), SYT1(1)	20619531	8	8	8	3	2	1	2	1	2	0	0.611	0.983	1.000
446	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH2(1), AMD1(1), AOC3(1), ASL(1), CKM(2), CPS1(1), GOT1(1), GOT2(2), NOS1(1), P4HB(1)	32642616	12	12	12	3	3	1	1	6	0	1	0.399	0.984	1.000
447	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	OCRL(2), PIK3C2A(1), PIK3C2G(1), PIK3CA(3), PIK3CB(1), PIK3CG(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1)	32871640	15	14	15	4	2	1	2	7	3	0	0.511	0.986	1.000
448	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(5), AKT2(1), AKT3(1), BAD(1), CDC42(1), CDKN2A(1), ERBB4(3), F2RL2(1), IGFBP1(1), IRS1(3), IRS2(2), MET(2), MYC(1), PAK3(2), PAK7(2), PARD3(1), PIK3CA(3), PIK3CD(2), PPP1R13B(1), PTEN(2), RPS6KA1(1), SHC1(1), SOS1(2), SOS2(2), YWHAE(1), YWHAG(1)	57102125	44	43	42	10	4	9	3	20	7	1	0.203	0.986	1.000
449	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(3), AXIN1(1), CREBBP(1), CSNK2A1(1), CTBP1(1), CTNNB1(2), MYC(1)	21629345	10	10	10	4	0	2	2	3	3	0	0.673	0.986	1.000
450	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(1), ACTG1(1), CDC42(1), CREBBP(1), CSNK2A1(1), CTNNA3(1), CTNNB1(2), CTNND1(1), ERBB2(1), FARP2(1), FYN(1), IGF1R(3), INSR(1), IQGAP1(1), LEF1(1), LMO7(1), MET(2), MLLT4(1), PARD3(1), PTPRB(2), PTPRJ(1), PVRL1(3), PVRL4(1), SNAI2(1), SRC(2), TCF7L1(4), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(2), VCL(2), WASL(1), YES1(1)	88331140	46	40	46	5	3	4	9	17	13	0	0.0234	0.986	1.000
451	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH2(1), CYP2C19(1), CYP2C9(1), ESCO2(2), HADHA(1)	22800209	6	6	6	2	1	0	2	2	1	0	0.759	0.987	1.000
452	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLAT(1), GOT1(1), GOT2(2), HK2(3), HK3(1), LDHA(2), PC(3), PDHA2(1), PDHX(1), PFKP(2), PKLR(1)	31342763	19	19	19	5	7	4	2	5	1	0	0.206	0.987	1.000
453	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP4A(1), ATP6V0C(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), COX7B(1), CYC1(1), NDUFA6(1), NDUFA7(2), NDUFA9(2), NDUFS1(1), NDUFS5(1), NDUFS8(1), NDUFV2(1), NDUFV3(1), SDHA(1), SDHD(1), UQCRC1(2), UQCRC2(1)	41104362	26	26	26	7	4	5	5	7	5	0	0.328	0.990	1.000
454	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(2), F7(1), F8(3), F9(1), FGA(1), PLG(1), SERPINB2(1), VWF(1)	26053724	11	11	11	4	4	0	1	3	3	0	0.568	0.990	1.000
455	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), PFKP(2), PRPS1(2), RPIA(1), TKTL2(1)	17953879	7	7	7	3	2	2	0	3	0	0	0.672	0.990	1.000
456	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	HEXA(1), HEXB(1), LCT(1), MAN2C1(1), MANBA(1)	12194257	5	5	5	3	2	1	1	0	1	0	0.787	0.991	1.000
457	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CPS1(1)	14011107	1	1	1	2	0	0	0	0	0	1	0.967	0.991	1.000
458	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	HEXA(1), HEXB(1), LCT(1), SLC33A1(1), ST6GALNAC6(1), ST8SIA1(1)	12158921	6	6	6	4	1	1	3	0	1	0	0.835	0.991	1.000
459	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	AGPAT2(1), AGPAT6(2), CDS2(1), CHAT(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), ESCO2(2), GNPAT(4), PCYT1A(1), PLA2G2A(1), PLA2G5(2), PLA2G6(1), PLD2(1), PPAP2C(1), PTDSS2(1)	48077698	29	27	29	7	6	5	5	5	8	0	0.304	0.992	1.000
460	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ESCO2(2), HADHA(1)	19154606	3	3	3	1	0	0	1	1	1	0	0.887	0.993	1.000
461	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), PFKP(2), PRPS1(2), RPIA(1)	15126447	6	6	6	3	2	2	0	2	0	0	0.716	0.993	1.000
462	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(1), LPL(1)	13588924	2	2	2	2	0	1	0	0	1	0	0.923	0.993	1.000
463	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(1), MAP2K6(1), TGFBR1(1), TGFBR2(1), TLR2(1)	21857495	5	5	5	2	0	0	2	1	2	0	0.810	0.994	1.000
464	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ALDH2(1), AOC3(1), DPYS(2), GAD2(1), HADHA(1), MLYCD(1), SDS(1)	21439603	9	9	8	4	1	2	1	3	2	0	0.830	0.995	1.000
465	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD28(1), CD3D(1), DTYMK(1), FBXW7(1), LCK(1), NCK1(2), NFAT5(3), PAK3(2), PAK7(2), PLCG1(1), RASGRP1(1), SOS1(2), SOS2(2)	41021700	21	21	21	5	3	4	3	8	3	0	0.283	0.995	1.000
466	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	HEXA(1), HEXB(1), LCT(1), MAN2B1(2), MAN2C1(1), MANBA(1), SPAM1(1)	25442347	8	8	8	3	2	1	1	1	3	0	0.738	0.995	1.000
467	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(1)	16474772	4	4	4	2	1	0	0	1	2	0	0.889	0.995	1.000
468	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), INSR(1), ITCH(1), MAGI1(1), MAGI2(1), RERE(2)	17695704	8	8	8	4	1	2	3	0	2	0	0.796	0.996	1.000
469	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(4), CASP6(1)	14231875	5	5	5	4	0	2	1	1	1	0	0.960	0.996	1.000
470	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), GOSR2(1), STX4(1), VAMP3(1), VTI1A(1)	12285759	5	5	5	4	1	0	1	2	1	0	0.933	0.996	1.000
471	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK2A(1), CAMK2B(1), HDAC5(1), MEF2B(1), PPARA(1), SYT1(1)	14875428	6	6	6	6	2	1	1	1	1	0	0.987	0.996	1.000
472	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	CYP11A1(2), HSD11B2(1), PTGER4(1), S100A6(1)	15207613	5	5	5	3	1	2	0	2	0	0	0.836	0.996	1.000
473	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP6(1), JUN(1), MAP3K1(3), PRKDC(5), PTPN13(2), RB1(2), SPTAN1(1)	29639709	15	14	15	6	3	2	1	4	5	0	0.779	0.996	1.000
474	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(3), AXIN1(1), CTNNB1(2), DVL2(2), DVL3(1), FZD10(1), FZD3(1), FZD8(2), JUN(1), MAPK10(1), MYC(1), PPP2R5C(1), PRKD1(3), WNT11(1), WNT4(1), WNT5B(1)	44375304	23	23	23	6	7	2	6	6	2	0	0.247	0.997	1.000
475	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), CANT1(1), CTPS2(1), DPYS(2), DTYMK(1), ITPA(1), NT5E(1), POLB(1), POLD1(1), POLE(1), POLL(1), POLQ(2), POLR1B(2), POLR2A(1), POLR2B(1), RRM1(1), TK1(2), TXNRD1(1)	42282024	22	22	21	5	2	4	3	7	6	0	0.340	0.997	1.000
476	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(1), APOA4(1), LPL(1), LRP1(5), SOAT1(1)	20209877	9	9	8	4	2	3	0	3	1	0	0.625	0.997	1.000
477	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY1(1), NPAS2(1)	12582294	3	3	3	5	0	2	0	0	1	0	0.993	0.997	1.000
478	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), MGAT2(1), MGAT3(1), RPN1(1)	14683852	5	5	5	3	1	2	0	2	0	0	0.823	0.997	1.000
479	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(5), AKT2(1), AKT3(1), BAD(1), FLOT2(1), INPP5D(1), ITPR1(2), ITPR2(6), LYN(1), NFATC1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(1), SOS1(2), SOS2(2), SYK(1)	54501461	34	33	32	9	8	7	2	9	8	0	0.219	0.998	1.000
480	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ATP6V0C(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), CDC42(1), JAM2(1), JUN(1), LYN(1), MAPK10(1), MET(2), PLCG1(1), PTPRZ1(7), SRC(2), TJP1(2)	51738118	26	24	26	6	4	2	5	12	3	0	0.349	0.998	1.000
481	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ADH1B(1), ADH4(1), ADH7(2), ALDH2(1), CPT1A(3), CPT1C(1), CYP4A11(2), HADH(1), HADHA(1)	36157238	13	12	12	4	4	2	0	6	1	0	0.500	0.998	1.000
482	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(5), AKT2(1), AKT3(1), APC(3), AXIN1(1), CTNNB1(2), DKK4(1), LRP1(5), NKD1(1), NKD2(1), PTPRA(1), SENP2(1)	29766622	23	23	20	8	4	6	1	8	4	0	0.571	0.998	1.000
483	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(3), AXIN1(1), CTNNB1(2), DLL1(1)	15837047	7	7	7	5	1	1	1	3	1	0	0.904	0.998	1.000
484	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ALAS1(1), AOC3(1), ATP6V0C(1), DMGDH(1), GARS(1), GCAT(1), PLCB2(1), PLCG1(1), SARDH(1), TARS(1)	31050110	10	8	10	3	2	2	2	3	1	0	0.539	0.998	1.000
485	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1B(1), ADH4(1), ADH7(2), AKR1D1(1), ALDH2(1), CEL(1)	17105790	7	7	7	4	1	1	0	5	0	0	0.862	0.998	1.000
486	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(1), ACTG1(1), ARHGEF2(2), CDC42(1), CTNNB1(2), EZR(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCK1(2), NCL(1), OCLN(1), TLR4(1), TUBA3C(1), TUBB2B(1), WASL(1)	38766570	26	23	23	9	2	7	4	7	6	0	0.607	0.998	1.000
487	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(1), ACTG1(1), ARHGEF2(2), CDC42(1), CTNNB1(2), EZR(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCK1(2), NCL(1), OCLN(1), TLR4(1), TUBA3C(1), TUBB2B(1), WASL(1)	38766570	26	23	23	9	2	7	4	7	6	0	0.607	0.998	1.000
488	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), CAPNS2(1), ITGB1(2), ITGB3(1), SPTAN1(1), SRC(2), TLN1(1)	20984933	9	9	9	4	2	2	1	3	1	0	0.724	0.998	1.000
489	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AKT1(5), AKT2(1), AKT3(1), APAF1(4), ATM(7), BAD(1), CASP6(1), CSF2RB(3), IL1R1(2), IRAK2(1), IRAK3(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PRKAR2A(1), TNFRSF1A(1), TP53(4), TRADD(1)	61570439	48	45	46	11	5	11	6	13	13	0	0.193	0.999	1.000
490	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(2), HS3ST2(1), NDST2(1), NDST3(1), NDST4(1)	15338941	7	7	7	6	1	1	1	3	1	0	0.953	0.999	1.000
491	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(4), CASP6(1), SPTAN1(1), TRADD(1)	24609412	7	7	7	5	0	2	1	1	3	0	0.960	0.999	1.000
492	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), NCOA3(1), NCOR2(1), POLR2A(1), RARA(1)	18344482	5	5	5	5	0	1	1	2	1	0	0.969	0.999	1.000
493	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(5), ATM(7), CDC6(1), CDC7(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(4), E2F3(1), ESPL1(2), HDAC5(1), HDAC8(1), MCM4(1), PRKDC(5), PTPRA(1), RB1(2), RBL1(1), TP53(4), WEE1(1)	80880193	41	37	38	8	3	7	4	13	14	0	0.194	0.999	1.000
494	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH2(1), AOC3(1), DDC(1), PRPS1(2)	18047993	5	5	5	3	2	0	1	2	0	0	0.836	0.999	1.000
495	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), BAD(1), CABIN1(1), CAMK2B(1), CDKN1A(1), CNR1(2), CREBBP(1), CSNK2A1(1), HRAS(17), IL2RA(1), JUNB(1), MEF2B(1), NFAT5(3), NFATC1(1), NFATC4(3), NUP214(3), RPL13A(1), SLA(4), SP1(1), VAV2(1)	67075344	46	43	31	11	7	3	17	10	9	0	0.188	0.999	1.000
496	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6V0C(1), ATP6V1A(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP7A(1), ATP7B(1), COX7B(1), NDUFS1(1), NDUFV2(1), SDHA(1), UQCRC1(2)	28130302	14	14	14	5	1	1	4	5	3	0	0.689	1.000	1.000
497	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(1), ALDH2(1), HADHA(1), LDHA(2), MLYCD(1), PCCA(1), SDS(1)	24418388	9	9	9	4	2	1	1	5	0	0	0.829	1.000	1.000
498	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	ALDH2(1), DOT1L(1), EHMT2(1), HADH(1), HADHA(1), HSD3B7(1), NSD1(4), OGDH(1), OGDHL(2), RDH14(1), SETD1A(3), SETDB1(1), TMLHE(1)	42870787	19	19	19	5	4	2	3	8	2	0	0.463	1.000	1.000
499	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC2(1), ANAPC5(2), CDC23(1), CDC27(1), CUL1(2), CUL2(1), CUL3(1), FBXW7(1), FZR1(1), ITCH(1), SMURF2(1)	29579833	14	13	14	5	2	5	3	1	3	0	0.461	1.000	1.000
500	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1B(1), ADH4(1), ADH7(2), AGPAT2(1), ALDH2(1), CEL(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), LCT(1), LPL(1), PPAP2C(1)	35473130	20	20	20	8	4	3	2	6	5	0	0.757	1.000	1.000
501	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(4), CASP6(1), GSN(1), MAP3K1(3), NUMA1(1), PRKDC(5), RASA1(2), RB1(2), SPTAN1(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(1), TRAF1(1)	50652047	25	23	25	9	2	4	4	6	9	0	0.733	1.000	1.000
502	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ALDH2(1), AOC3(1), AOX1(1), ASMT(1), CYP19A1(1), CYP1A2(1), CYP2A13(2), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), DDC(1), HAAO(1), HADHA(1), SDS(1), TDO2(2), WARS(1)	40618072	19	19	19	6	3	1	5	10	0	0	0.620	1.000	1.000
503	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), GTF2F2(1), POLR1A(1), POLR1B(2), POLR2A(1), POLR2B(1), POLR3B(1), POLR3D(1)	25845613	9	9	9	4	1	3	0	3	2	0	0.728	1.000	1.000
504	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(7), FSHR(1), MSH5(1), VDR(1)	25802320	10	10	10	9	1	2	2	3	2	0	0.995	1.000	1.000
505	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ABAT(1), ASL(1), CAD(1), DARS(1), GAD2(1), GOT1(1), GOT2(2), GPT(1), PC(3)	19172091	12	12	12	5	3	4	3	2	0	0	0.536	1.000	1.000
506	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(5), AKT2(1), AKT3(1), CBL(1), CDC42(1), CDKN2A(1), F2RL2(1), FLOT2(1), IGFBP1(1), IRS1(3), IRS2(2), LNPEP(2), PARD3(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PTEN(2), RPS6KA1(1), SHC1(1), SOS1(2), SOS2(2), YWHAE(1), YWHAG(1)	44005250	38	37	36	11	3	9	1	16	8	1	0.464	1.000	1.000
507	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	ABAT(1), ADSSL1(2), ASL(1), ASRGL1(1), CAD(1), DARS(1), DLAT(1), GAD2(1), GOT1(1), GOT2(2), GPT(1), PC(3), PDHA2(1)	27846490	17	17	17	8	5	4	4	2	2	0	0.755	1.000	1.000
508	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT10(1), GALNT12(1), GALNT14(1), GALNT2(1), GALNT7(1), GALNT8(1), GALNTL5(1)	23847328	8	8	8	5	2	0	1	4	1	0	0.944	1.000	1.000
509	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	GALT(2), GANAB(2), HK2(3), HK3(1), LCT(1), MGAM(1), PFKP(2)	23935646	12	12	12	6	4	4	2	1	1	0	0.636	1.000	1.000
510	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CANX(1), CD4(1), CD74(2), CTSS(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(2), HLA-DRA(1), HLA-E(1), HSP90AA1(3), HSPA5(1), KIR2DL3(1), KIR3DL1(1), KIR3DL2(1), RFX5(1), RFXAP(1)	34186983	20	20	20	8	6	5	2	4	3	0	0.620	1.000	1.000
511	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(4), BAD(1), CASP6(1), CD40LG(1), PTPN13(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(1), TRAF1(1)	31939949	13	13	13	7	3	2	1	4	3	0	0.927	1.000	1.000
512	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(1), ACACB(1), ACOT12(1), ACSS1(1), ACSS2(1), ALDH2(1), DLAT(1), HAGHL(1), LDHA(2), ME1(1), PC(3), PCK2(1), PDHA2(1), PKLR(1)	34518958	17	17	17	6	9	1	3	2	2	0	0.479	1.000	1.000
513	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), COL2A1(1), CPSF3(1), DHX16(1), DHX38(1), DHX8(3), DICER1(5), DNAJC8(1), GIPC1(1), NCBP1(1), PABPN1(1), POLR2A(1), PRPF3(1), PRPF4B(1), PRPF8(3), PTBP2(1), RBM17(1), RNMT(1), SF3A1(1), SF3A3(1), SF3B1(2), SPOP(1), SRRM1(1), U2AF1(1), U2AF2(1), XRN2(1)	78019857	35	32	35	7	3	9	6	11	6	0	0.181	1.000	1.000
514	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ALDH2(1), AOX1(1), BCAT1(1), HADHA(1), PCCA(1), SDS(1)	26531711	6	6	6	6	1	0	1	3	1	0	0.996	1.000	1.000
515	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IPMK(1), ISYNA1(2), OCRL(2), PI4KB(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIP4K2C(1), PIP5K1A(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1), PTEN(2)	54694509	23	22	23	8	4	0	4	7	7	1	0.767	1.000	1.000
516	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(1), ALDH2(1), DLAT(1), HAGHL(1), LDHA(2), ME1(1), PC(3), PDHA2(1), PKLR(1)	27260428	12	12	12	5	6	1	2	2	1	0	0.646	1.000	1.000
517	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1B(1), ADH4(1), ADH7(2), AGPAT2(1), AGPAT6(2), ALDH2(1), CEL(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), GK2(1), LCT(1), LPL(1), PPAP2C(1)	43191156	23	23	23	9	6	3	2	7	5	0	0.709	1.000	1.000
518	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY8(1), CACNA1A(2), CACNA1B(3), GNAS(3), GNB3(1), GRM4(2), PDE1A(1), PLCB2(1), TAS1R2(1), TAS1R3(1), TAS2R46(1), TAS2R7(1), TRPM5(1)	41830748	19	18	19	6	5	6	2	3	3	0	0.324	1.000	1.000
519	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(3), AXIN1(1), CTNNB1(2), TGFBR1(1), TGFBR2(1), TGFBR3(1)	26863620	9	9	9	8	0	2	3	3	1	0	0.985	1.000	1.000
520	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), ESR1(1), HNF4A(2), NR4A2(1), PPARA(1), RARA(1), THRA(1), VDR(1)	31126938	9	9	9	7	2	2	1	2	2	0	0.907	1.000	1.000
521	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(5), AKT2(1), AKT3(1), IFNAR2(1), IRF3(1), IRF5(2), JUN(1), LBP(1), MAP2K1(1), MAP2K6(1), MAP3K8(1), MAPK10(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), STAT1(1), TBK1(1), TLR2(1), TLR3(1), TLR4(1), TLR7(1), TLR8(1)	66231810	38	38	36	10	6	6	2	17	7	0	0.307	1.000	1.000
522	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(1), ACACB(1), ACSS1(1), ACSS2(1), ALDH2(1), HADHA(1), LDHA(2), MLYCD(1), PCCA(1)	29273847	11	11	11	5	3	1	1	5	1	0	0.820	1.000	1.000
523	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	GALT(2), HK2(3), HK3(1), HSD3B7(1), LCT(1), MGAM(1), PFKP(2), RDH14(1)	28406958	12	12	12	6	4	4	1	2	1	0	0.647	1.000	1.000
524	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(1), CANT1(1), CTPS2(1), DPYS(2), DTYMK(1), ITPA(1), NT5C1B(1), NT5E(1), POLD1(1), POLD3(1), POLE(1), POLE2(1), POLR1A(1), POLR1B(2), POLR2A(1), POLR2B(1), POLR3B(1), RRM1(1), TK1(2), TXNRD1(1)	59658423	23	23	22	6	2	2	4	8	7	0	0.592	1.000	1.000
525	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BFAR(2), CAD(1), FAIM2(1), MAP3K1(3), MAPK10(1), MAPK8IP2(1), MET(2), NFAT5(3), PTPN13(2), TP53(4)	53439405	20	20	20	6	3	1	2	7	7	0	0.507	1.000	1.000
526	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	CCR6(1), FPR1(1), FSHR(1), GALT(2), NTSR2(1), OPRL1(1), SSTR2(1), TACR3(3), TSHR(2)	38735763	13	13	13	5	0	6	3	4	0	0	0.493	1.000	1.000
527	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CREBBP(1), ERCC3(1), ESR1(1), HDAC5(1), NCOR2(1), POLR2A(1)	34204714	7	7	7	8	0	2	0	3	2	0	0.987	1.000	1.000
528	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ALDH2(1), AOX1(1), BCAT1(1), DBT(1), HADH(1), HADHA(1), PCCA(1)	31732300	8	8	8	5	1	1	2	3	1	0	0.961	1.000	1.000
529	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GNT1(1), B3GNT3(1), B3GNT5(1), FUT1(1), FUT3(2), PIGO(1), PIGS(1), PIGZ(2), ST6GALNAC6(1), ST8SIA1(1)	35723166	12	12	12	7	0	4	5	1	2	0	0.820	1.000	1.000
530	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(2), AMY2A(1), ENPP1(2), GANAB(2), GBE1(1), GYS2(1), HK2(3), HK3(1), MGAM(1), PYGB(1), UGT1A1(1), UGT1A3(2), UGT1A4(1)	41786643	19	19	19	8	3	4	5	4	3	0	0.615	1.000	1.000
531	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(1), ALG12(1), ALG13(2), ALG3(2), GANAB(2), MAN1C1(1), MGAT2(1), MGAT3(1), MGAT5B(2), RPN1(1), STT3B(1)	31272321	15	15	15	6	3	5	2	5	0	0	0.587	1.000	1.000
532	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CREBBP(1), JUN(1), LPL(1), ME1(1), MYC(1), NCOR2(1), PIK3CA(3), PIK3R1(2), PPARA(1), PRKAR2A(1), RB1(2), SP1(1), STAT5B(1)	46610489	17	17	17	9	3	2	4	4	4	0	0.868	1.000	1.000
533	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	CDC42(1), CLDN14(1), CLDN6(1), CTNNA3(1), CTNNB1(2), CTNND1(1), CYBA(1), EZR(1), ITGAL(4), ITGAM(2), ITGB1(2), ITGB2(1), JAM2(1), MLLT4(1), MMP2(1), OCLN(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PLCG1(1), PTK2B(2), RAP1A(1), VAV2(1), VCAM1(2), VCL(2)	91625477	45	42	45	10	8	9	4	15	9	0	0.153	1.000	1.000
534	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(5), ANAPC1(1), ANAPC2(1), ANAPC5(2), ATM(7), ATR(3), CDC23(1), CDC27(1), CDC6(1), CDC7(1), CDKN1A(1), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(4), CREBBP(1), CUL1(2), E2F3(1), ESPL1(2), FZR1(1), MCM4(1), PRKDC(5), RB1(2), RBL1(1), RBL2(1), SMC1A(1), TP53(4), WEE1(1), YWHAE(1), YWHAG(1)	99856572	56	49	53	12	3	11	7	16	19	0	0.149	1.000	1.000
535	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH4(1), ADH7(2), ALDH2(1), ALDOB(1), DLAT(1), HK2(3), HK3(1), LDHA(2), PDHA2(1), PFKP(2), PKLR(1)	36053187	17	17	17	8	6	3	1	6	1	0	0.678	1.000	1.000
536	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH4(1), ADH7(2), ALDH2(1), ALDOB(1), DLAT(1), HK2(3), HK3(1), LDHA(2), PDHA2(1), PFKP(2), PKLR(1)	36053187	17	17	17	8	6	3	1	6	1	0	0.678	1.000	1.000
537	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(1), ADH1B(1), ADH4(1), ADH7(2), ALDH2(1), ALDOB(1), DLAT(1), HK2(3), HK3(1), LDHA(2), PDHA2(1), PFKP(2), PGAM4(1), PKLR(1)	42930212	20	20	20	9	7	3	1	7	2	0	0.623	1.000	1.000
538	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML6(1), CDS2(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), INPP5D(1), ITPR1(2), ITPR2(6), OCRL(2), PI4KB(1), PIK3C2A(1), PIK3C2G(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), PIP4K2C(1), PIP5K1A(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1), PTEN(2)	91542412	50	45	50	12	11	7	5	13	13	1	0.178	1.000	1.000
539	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(2), RPL12(1), RPL13A(1), RPL18A(1), RPL4(1), RPL9(2), RPS2(1), RPS4X(1), RPS6KA1(1), RPS6KB2(1), UBC(1)	38508163	13	12	13	8	3	5	2	2	1	0	0.917	1.000	1.000
540	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ANGPTL4(1), AQP7(1), CPT1A(3), CPT1C(1), CYP4A11(2), GK2(1), LPL(1), ME1(1), PCK2(1), PLTP(1), PPARA(1), SLC27A4(2), UBC(1)	48320230	17	17	16	6	6	3	3	4	1	0	0.462	1.000	1.000
541	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(5), AKT2(1), AKT3(1), CBL(1), CNTF(1), CREBBP(1), CSF2RA(1), CSF2RB(3), CSF3R(1), GHR(1), IFNAR2(1), IFNGR1(1), IL11(1), IL11RA(1), IL12RB2(1), IL22(1), IL23R(1), IL2RA(1), IL2RG(1), IL7R(3), JAK1(1), JAK2(1), LEPR(1), MYC(1), OSMR(1), PIAS2(1), PIAS3(1), PIK3CA(3), PIK3CB(1), PIK3CD(2), PIK3CG(1), PIK3R1(2), PIK3R5(5), SOS1(2), SOS2(2), SPRED2(1), STAM2(1), STAT1(1), STAT2(1), STAT4(1), STAT5B(1), STAT6(1), TPO(1), TYK2(1)	107140863	62	58	60	16	13	12	6	20	11	0	0.160	1.000	1.000
542	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(2), CD38(2), CD3D(1), CD4(1), CD44(1), CD5(2), CR1(1), CSF2RA(1), CSF3R(1), FCER2(1), FLT3LG(1), HLA-DRA(1), IL11(1), IL11RA(1), IL1R1(2), IL2RA(1), IL7R(3), ITGA3(2), ITGAM(2), ITGB3(1), KIT(4), THPO(2), TPO(1)	59986885	35	32	35	11	12	9	2	10	2	0	0.240	1.000	1.000
543	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADM(1), ARRB1(1), ARRB2(1), ATF5(2), ATP2A2(2), CACNB3(1), CAMK2A(1), CAMK2B(1), CNN2(1), CORIN(1), CRH(1), CRHR1(1), DGKZ(2), GBA2(2), GJA1(1), GNB3(1), GNG5(1), GNGT1(1), GUCA2B(1), GUCY1A3(1), IGFBP1(1), ITPR1(2), ITPR2(6), JUN(1), MIB1(1), NOS1(1), PDE4B(1), PDE4D(1), PLCB3(1), PLCD1(1), PLCG1(1), PRKAR2A(1), PRKD1(3), RGS6(1), RGS9(1), RLN1(1), RYR1(8), RYR2(4), RYR3(1), SLC8A1(3), SP1(1), TNXB(3), USP5(1)	127275128	76	67	74	19	14	16	9	24	13	0	0.0719	1.000	1.000
544	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(1), ABCA10(1), ABCA12(2), ABCA13(1), ABCA2(2), ABCA3(3), ABCA4(1), ABCA5(3), ABCA6(1), ABCA9(1), ABCB11(4), ABCB4(1), ABCB5(1), ABCB6(1), ABCB7(2), ABCC10(4), ABCC2(2), ABCC3(1), ABCC4(1), ABCC5(2), ABCC6(2), ABCC9(1), ABCD1(4), ABCD4(1), ABCG8(2), CFTR(2)	86587267	47	44	47	14	11	9	5	11	11	0	0.237	1.000	1.000
545	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(5), AKT3(1), CAPN6(1), CAPN9(1), CDC42(1), FYN(1), GIT2(1), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), ITGAD(2), ITGAL(4), ITGAM(2), ITGAV(1), ITGAX(1), ITGB1(2), ITGB2(1), ITGB3(1), ITGB8(1), MAP2K1(1), MAP2K6(1), MAPK10(1), MAPK4(1), PAK3(2), RAPGEF1(2), SDCCAG8(1), SHC1(1), SOS1(2), SRC(2), TLN1(1), TNS1(3), VAV2(1), VCL(2), ZYX(1)	98579801	57	53	55	17	12	14	3	19	9	0	0.330	1.000	1.000
546	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(1), ADRA1A(1), ADRA2B(1), ADRB1(1), CALCR(1), CHRM4(1), CHRM5(1), CNR1(2), CNR2(2), CRHR1(1), CYSLTR2(1), DRD4(2), DRD5(3), F2RL2(1), FPR1(1), FSHR(1), GABRA2(2), GABRA3(1), GABRA6(1), GABRB3(1), GABRD(1), GABRE(1), GABRQ(2), GABRR1(1), GABRR2(1), GHR(1), GLP2R(2), GLRA3(1), GPR156(1), GPR35(1), GRIA1(1), GRIA2(2), GRIA4(1), GRID1(1), GRID2(1), GRIK1(2), GRIK2(1), GRIK3(1), GRIN2A(2), GRIN2B(4), GRIN2D(3), GRIN3A(1), GRM1(3), GRM2(1), GRM4(2), GRM6(3), HCRTR1(1), HRH1(1), HRH2(1), HTR2B(1), HTR5A(1), LEPR(1), LTB4R(2), LTB4R2(1), MCHR1(1), MTNR1B(1), NPBWR1(1), NPBWR2(1), NPFFR2(1), NTSR2(1), OPRL1(1), PARD3(1), PRSS1(1), PTGER3(1), PTGER4(1), PTH2R(1), RXFP1(1), RXFP2(1), SSTR2(1), TAAR5(1), TACR3(3), THRA(1), TSHR(2)	163637628	98	83	98	26	19	23	10	38	8	0	0.0484	1.000	1.000
547	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(4), DOT1L(1), EED(2), EHMT2(1), EZH1(2), FBXO11(2), HCFC1(1), HSF4(1), JMJD4(1), KDM6A(1), MEN1(3), NSD1(4), PAXIP1(1), PRDM9(5), PRMT8(3), SATB1(1), SETD1A(3), SETD2(1), SETDB1(1), SUV420H1(1), SUV420H2(1), WHSC1L1(2)	87758290	42	40	41	12	6	7	10	12	7	0	0.364	1.000	1.000
548	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	AKT1(5), CDKL2(1), CDS2(1), CLK1(1), CSNK2A1(1), DGKA(1), DGKB(3), DGKE(1), DGKG(1), DGKH(1), DGKQ(1), DGKZ(2), OCRL(2), PIK3C2A(1), PIK3C2G(1), PIK3CA(3), PIK3CB(1), PIK3CG(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1), PRKAR2A(1), PRKD1(3), PRKG1(1), RPS6KA1(1), RPS6KA4(1), TGFBR1(1)	83003966	42	41	40	13	4	8	7	12	11	0	0.475	1.000	1.000
549	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADRA1A(1), ADRB1(1), ATP2A2(2), ATP2B3(1), ATP2B4(2), CACNA1A(2), CACNA1B(3), CACNA1C(2), CACNA1D(4), CACNA1E(5), CACNA1G(3), CACNA1H(1), CACNA1S(1), CALML6(1), CAMK2A(1), CAMK2B(1), CD38(2), CHRM5(1), CYSLTR2(1), ERBB2(1), ERBB3(3), ERBB4(3), GNAL(2), GNAS(3), GRIN2A(2), GRIN2D(3), GRM1(3), HRH1(1), HRH2(1), HTR2B(1), HTR5A(1), ITPR1(2), ITPR2(6), LTB4R2(1), MYLK(4), NOS1(1), PDE1A(1), PDGFRB(1), PHKA2(3), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCG1(1), PPID(1), PTGER3(1), PTK2B(2), RYR1(8), RYR2(4), RYR3(1), SLC8A1(3), SLC8A3(2), SPHK2(1), TACR3(3), VDAC1(1), VDAC3(1)	198343139	118	102	117	36	24	27	14	37	16	0	0.129	1.000	1.000
550	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	CD44(1), COL11A1(1), COL11A2(2), COL1A1(1), COL2A1(1), COL3A1(2), COL4A1(3), COL4A2(2), COL4A4(2), COL4A6(1), COL5A1(4), COL5A3(8), COL6A2(3), COL6A3(2), COL6A6(3), FN1(3), FNDC3A(2), HMMR(1), HSPG2(1), ITGA10(3), ITGA3(2), ITGA7(2), ITGA8(1), ITGA9(1), ITGAV(1), ITGB1(2), ITGB3(1), ITGB8(1), LAMA2(1), LAMA3(3), LAMA4(4), LAMA5(2), LAMB1(1), LAMB2(1), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), RELN(2), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SV2C(1), THBS1(1), THBS2(2), THBS3(1), THBS4(1), TNC(1), TNN(1), TNR(3), TNXB(3), VTN(1), VWF(1)	165107238	97	88	97	36	17	21	8	35	16	0	0.645	1.000	1.000
551	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(1), COL11A1(1), COL11A2(2), COL1A1(1), COL2A1(1), COL3A1(2), COL4A1(3), COL4A2(2), COL4A4(2), COL4A6(1), COL5A1(4), COL5A3(8), COL6A2(3), COL6A3(2), COL6A6(3), DSG3(1), DSG4(1), FN1(3), GJA1(1), GJA3(2), GJA8(1), GJD2(1), KRT18(1), KRT20(1), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT33B(1), KRT35(2), KRT6C(1), KRT85(3), KRT9(1), LAMA2(1), LAMA3(3), LAMA4(4), LAMA5(2), LAMB1(1), LAMB2(1), LAMB4(1), LAMC1(2), LAMC2(1), LAMC3(2), NES(1), RELN(2), THBS1(1), THBS2(2), THBS3(1), THBS4(1), TNC(1), TNN(1), TNR(3), TNXB(3), VIM(1), VTN(1), VWF(1)	183550705	98	86	98	39	18	23	7	30	20	0	0.784	1.000	1.000
552	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADRA1A(1), ADRB1(1), ARRB1(1), ARRB2(1), ATP1A4(1), ATP2A2(2), ATP2B3(1), CACNA1A(2), CACNA1B(3), CACNA1C(2), CACNA1D(4), CACNA1E(5), CACNA1S(1), CACNB3(1), CAMK2A(1), CAMK2B(1), CHRM4(1), CHRM5(1), GJA1(1), GNB3(1), GNG5(1), GNGT1(1), ITPR1(2), ITPR2(6), MIB1(1), PLCB3(1), PRKAR2A(1), PRKD1(3), RGS6(1), RGS9(1), RYR1(8), RYR2(4), RYR3(1), SLC8A1(3), SLC8A3(2), USP5(1)	137841121	75	72	74	26	12	20	10	20	13	0	0.318	1.000	1.000
553	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR2A(1), ACVR2B(1), AMHR2(1), CCL23(1), CCL24(1), CCR6(1), CD40LG(1), CNTF(1), CSF2RA(1), CSF2RB(3), CSF3R(1), CXCL13(1), CXCL5(1), FLT3LG(1), FLT4(1), GHR(1), IFNAR2(1), IFNGR1(1), IL11(1), IL11RA(1), IL12RB2(1), IL17RB(1), IL18RAP(1), IL1R1(2), IL22(1), IL23R(1), IL2RA(1), IL2RG(1), IL7R(3), INHBA(2), INHBC(1), INHBE(1), KDR(2), KIT(4), LEPR(1), MET(2), OSMR(1), PDGFRB(1), PF4V1(1), RELT(1), TGFBR1(1), TGFBR2(1), TNFRSF14(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF9(1), TNFSF15(1), TNFSF4(1), TNFSF9(1), TPO(1), VEGFA(1)	130792366	62	56	62	22	15	11	13	14	9	0	0.412	1.000	1.000
554	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(3), APC2(1), AXIN1(1), CAMK2A(1), CAMK2B(1), CREBBP(1), CSNK2A1(1), CTBP1(1), CTBP2(1), CTNNB1(2), CUL1(2), DAAM1(2), DKK4(1), DVL2(2), DVL3(1), FZD10(1), FZD3(1), FZD8(2), JUN(1), LEF1(1), LRP5(2), MAPK10(1), MMP7(1), MYC(1), NFAT5(3), NFATC1(1), NFATC4(3), NKD1(1), NKD2(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(1), PPP2R1A(3), PPP2R1B(1), PPP2R2B(1), PRICKLE1(1), SENP2(1), TCF7L1(4), TCF7L2(1), TP53(4), VANGL1(2), WNT11(1), WNT4(1), WNT5B(1)	118818054	66	56	65	21	12	8	9	18	19	0	0.405	1.000	1.000
555	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(1), CD28(1), CD4(1), CD40LG(1), CDH4(1), CLDN14(1), CLDN6(1), CNTNAP1(1), GLG1(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(2), HLA-DRA(1), HLA-E(1), ITGA8(1), ITGA9(1), ITGAL(4), ITGAM(2), ITGAV(1), ITGB1(2), ITGB2(1), ITGB8(1), JAM2(1), MADCAM1(1), MPZ(1), NCAM2(1), NEO1(1), NRXN1(4), NRXN2(1), NRXN3(2), OCLN(1), PDCD1(1), PDCD1LG2(1), PVRL1(3), SDC1(1), SDC2(1), SDC3(1), SDC4(1), VCAM1(2), VCAN(1)	108803411	54	52	54	25	13	9	9	14	9	0	0.838	1.000	1.000
556	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(3), ADSSL1(2), AK7(1), AMPD1(1), AMPD2(2), AMPD3(1), CANT1(1), ENPP1(2), GMPS(1), GUCY1A3(1), GUK1(1), IMPDH2(1), ITPA(1), NPR1(2), NT5C1B(1), NT5E(1), PAPSS1(2), PDE1A(1), PDE2A(1), PDE4B(1), PDE4D(1), PDE5A(2), PDE7B(1), PFAS(1), PKLR(1), POLD1(1), POLD3(1), POLE(1), POLE2(1), POLR1A(1), POLR1B(2), POLR2A(1), POLR2B(1), POLR3B(1), PPAT(1), PRPS1(2), RRM1(1), XDH(1)	120242059	51	48	51	22	12	5	5	19	10	0	0.921	1.000	1.000
557	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(2), AMY2A(1), ASCC3(1), DDX18(1), DDX23(3), DDX4(2), DDX47(1), DDX51(1), DDX52(1), ENPP1(2), ENTPD7(1), EP400(4), ERCC3(1), GBE1(1), GYS2(1), HK2(3), HK3(1), MGAM(1), MOV10L1(1), NUDT8(1), PYGB(1), SETX(2), SMARCA5(1), UGT1A1(1), UGT1A3(2), UGT1A4(1), UGT2A1(2), UGT2B7(2)	90936034	42	40	40	20	4	7	10	12	9	0	0.875	1.000	1.000
558	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY3(1), ADCY7(1), ADCY8(1), AMPD1(1), AMPD2(2), AMPD3(1), CANT1(1), ENPP1(2), GMPS(1), GUCY1A3(1), GUK1(1), IMPDH2(1), ITPA(1), NPR1(2), NT5E(1), PAPSS1(2), PDE1A(1), PDE4B(1), PDE4D(1), PDE5A(2), PDE7B(1), PFAS(1), PKLR(1), POLB(1), POLD1(1), POLE(1), POLL(1), POLQ(2), POLR1B(2), POLR2A(1), POLR2B(1), PPAT(1), PRPS1(2), RRM1(1)	94454273	42	40	42	16	12	6	4	14	6	0	0.634	1.000	1.000
559	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), DMD(2), MYBPC2(2), MYH3(2), MYH6(3), MYH7(3), MYH8(1), MYOM1(2), NEB(1), TCAP(1), TNNT3(1), TPM3(1), TTN(18), VIM(1)	99727093	39	37	38	14	4	11	6	11	7	0	0.541	1.000	1.000
560	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADRA1A(1), ADRB1(1), CCR6(1), CHRM4(1), CHRM5(1), CNR1(2), CNR2(2), DRD4(2), DRD5(3), F2RL2(1), FPR1(1), FSHR(1), GALT(2), GPR173(1), GPR35(1), GPR4(1), GPR87(1), HCRTR1(1), HRH1(1), HRH2(1), HTR2B(1), HTR5A(1), LTB4R(2), MTNR1B(1), NTSR2(1), OPRL1(1), OR12D3(1), OR5V1(1), OR7A5(1), PTGER4(1), RGR(1), SSTR2(1)	89878553	39	36	39	15	5	11	4	17	2	0	0.441	1.000	1.000
561	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG10B(1), ALG12(1), ALG13(2), ALG3(2), B3GNT1(1), C1GALT1(1), CHSY1(1), EXT1(1), EXT2(2), GALNT10(1), GALNT12(1), GALNT14(1), GALNT2(1), GALNT7(1), GALNT8(1), GALNTL5(1), GANAB(2), HS3ST2(1), MAN1C1(1), MGAT2(1), MGAT3(1), MGAT5B(2), NDST2(1), NDST3(1), NDST4(1), RPN1(1), STT3B(1), XYLT2(1)	81456471	33	33	33	18	6	6	5	13	3	0	0.927	1.000	1.000
562	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(7), CDKN1A(1), CDKN2A(1), CDKN2C(1), CREB3L3(3), E2F3(1), GBA2(2), MCM4(1), MYC(1), MYT1(1), POLE(1), POLE2(1), RB1(2), RBL1(1), TNXB(3), TP53(4), WEE1(1)	56851810	32	31	32	12	3	6	4	11	8	0	0.692	1.000	1.000
563	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(1), AKT1(5), AKT2(1), AKT3(1), CAMKK2(1), CPT1A(3), CPT1C(1), IRS1(3), IRS2(2), JAK1(1), JAK2(1), LEPR(1), MAPK10(1), PCK2(1), PPARA(1), PPARGC1A(3), PRKAG2(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(1), TYK2(1)	61197982	32	29	30	13	6	7	4	12	3	0	0.632	1.000	1.000
564	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(1), C1QA(1), C1R(1), C2(2), C3(1), C4BPA(1), C5(1), C6(1), C7(2), CD46(1), CR1(1), F10(2), F7(1), F8(3), F9(1), FGA(1), PLG(1), PROC(1), PROS1(2), SERPINA1(1), VWF(1)	66546903	27	25	27	12	7	1	1	11	7	0	0.859	1.000	1.000
565	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(1), ASCC3(1), DDX18(1), DDX23(3), DDX4(2), DDX47(1), DDX51(1), DDX52(1), ENTPD7(1), EP400(4), ERCC3(1), MOV10L1(1), NUDT8(1), SETX(2), SMARCA5(1), SPR(1)	46284707	24	24	22	12	2	3	6	7	6	0	0.894	1.000	1.000
566	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	CELSR1(3), CELSR2(1), CELSR3(1), DRD4(2), EMR2(1), FSHR(1), GPR116(1), GPR133(1), GRM1(3), LPHN2(1), LPHN3(2), LTB4R2(1), SSTR2(1), TAAR5(1), TSHR(2), VN1R1(2)	49283955	24	23	24	12	2	4	5	11	2	0	0.856	1.000	1.000
567	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(1), CTBP1(1), CTBP2(1), DLL1(1), DTX1(2), DVL2(2), DVL3(1), MAML1(1), MAML3(1), NCOR2(1), NOTCH2(1), NOTCH3(1), NOTCH4(4), NUMBL(1), RBPJ(1)	51093154	20	20	20	10	3	5	2	6	4	0	0.893	1.000	1.000
568	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP6(2), CSNK1G3(1), DHH(1), GAS1(1), GLI2(3), GLI3(1), LRP2(2), PTCH1(2), PTCH2(1), SUFU(1), WNT11(1), WNT4(1), WNT5B(1), ZIC2(2)	44899595	20	19	20	10	8	2	3	3	4	0	0.736	1.000	1.000
569	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), MCM10(1), MCM4(1), POLD1(1), POLD3(1), POLE(1), POLE2(1), UBC(1)	37351101	9	9	9	12	2	0	1	4	2	0	1.000	1.000	1.000
570	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ALDH2(1), ALDH5A1(1), GAD2(1), HADHA(1), PDHA2(1), SDS(1)	19043630	8	8	8	5	2	3	0	3	0	0	0.847	1.000	1.000
571	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), ETV5(1), IL12RB2(1), JAK2(1), JUN(1), MAP2K6(1), STAT4(1), TYK2(1)	13813049	8	8	8	5	5	0	0	3	0	0	0.862	1.000	1.000
572	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(1), ALDH2(1), ATP6V0C(1), DOT1L(1), EHMT2(1), HADHA(1), SDS(1), TMLHE(1)	27277542	8	8	8	5	1	1	0	6	0	0	0.924	1.000	1.000
573	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	DEGS1(1), DEGS2(1), LCT(1), PPAP2C(1), SMPD2(1), SMPD4(1), SPHK2(1)	26439710	7	7	7	6	2	1	1	3	0	0	0.976	1.000	1.000
574	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2F2(1), GTF2IRD1(1), TAF1L(2), TAF2(2), TAF6L(1)	26556293	7	7	7	6	3	2	1	1	0	0	0.943	1.000	1.000
575	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CD4(1), IL12RB2(1), JAK2(1), STAT4(1), TYK2(1)	10898293	6	6	6	5	4	0	0	2	0	0	0.931	1.000	1.000
576	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	F2RL2(1), JUN(1), PLD2(1), RASAL1(1), SRC(2)	20231485	6	6	6	5	3	1	0	2	0	0	0.916	1.000	1.000
577	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CAPNS2(1), NFATC1(1), SYT1(1)	17991013	4	4	4	3	2	1	1	0	0	0	0.894	1.000	1.000
578	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CD28(1), CD4(1), IFNGR1(1), IL12RB2(1)	14812756	4	4	4	3	2	0	1	1	0	0	0.888	1.000	1.000
579	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(1), CD44(1), TNFRSF1A(1), TNFRSF1B(1)	9647564	4	4	4	3	1	2	0	1	0	0	0.874	1.000	1.000
580	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	LCT(1), PPAP2C(1), SMPD2(1)	17885580	3	3	3	4	1	0	1	1	0	0	0.991	1.000	1.000
581	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH2(1), HADHA(1), SDS(1)	8971898	3	3	3	3	1	0	0	2	0	0	0.958	1.000	1.000
582	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	JAK1(1), JAK2(1), TYK2(1)	7739156	3	3	3	3	1	1	0	1	0	0	0.919	1.000	1.000
583	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	JAK1(1), JAK2(1), TYK2(1)	7739156	3	3	3	3	1	1	0	1	0	0	0.919	1.000	1.000
584	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL16(2)	7319827	2	2	2	4	0	1	1	0	0	0	0.972	1.000	1.000
585	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST6GALNAC2(1), ST8SIA1(1)	4170498	2	2	2	3	0	0	2	0	0	0	0.981	1.000	1.000
586	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR39(1)	7272122	2	2	2	3	1	1	0	0	0	0	0.949	1.000	1.000
587	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	FASN(1), HADHA(1)	10532116	2	2	2	2	0	0	0	2	0	0	0.941	1.000	1.000
588	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	JAK1(1), STAT1(1)	8988073	2	2	2	2	0	1	0	1	0	0	0.877	1.000	1.000
589	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), RETN(1)	4278226	2	2	2	2	0	2	0	0	0	0	0.828	1.000	1.000
590	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH2(1)	5896802	1	1	1	2	0	0	0	1	0	0	0.978	1.000	1.000
591	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH2(1)	5896802	1	1	1	2	0	0	0	1	0	0	0.978	1.000	1.000
592	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(1)	9871113	1	1	1	4	1	0	0	0	0	0	0.995	1.000	1.000
593	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1)	9212952	1	1	1	3	0	0	1	0	0	0	0.996	1.000	1.000
594	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	MEF2B(1)	5589475	1	1	1	2	1	0	0	0	0	0	0.978	1.000	1.000
595	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	SYT1(1)	15956328	1	1	1	3	0	1	0	0	0	0	0.986	1.000	1.000
596	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(1)	6207637	1	1	1	2	0	1	0	0	0	0	0.984	1.000	1.000
597	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	HSD17B1(1), HSD17B3(1)	5962250	2	1	2	2	0	0	1	1	0	0	0.953	1.000	1.000
598	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6		4086469	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
599	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5		2398777	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
600	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6		4020886	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
601	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		1216252	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
602	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4		3364954	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
603	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		534927	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
604	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2		1340702	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
605	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		375841	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		1557829	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8		4731453	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4		2881161	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
609	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6		2188714	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
610	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6		4459118	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		1262882	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9		6360101	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6		2866274	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4		2491664	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15		10701879	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23		7765075	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
