Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q ZFPM1 24 (39%) 38 0.43268 1 0.098799 1 0.37489 1 0.87178 1 0.24003 1 0.74714 1 0.61031 1 0.92097 1 0.7424 1 0.53516 1 LACTB 19 (31%) 43 0.074059 1 0.37486 1 0.89306 1 0.56953 1 1 1 0.31489 1 0.93409 1 0.74991 1 0.64027 1 0.34046 1 CCDC102A 17 (27%) 45 0.66019 1 0.58963 1 1 1 0.50505 1 0.97642 1 0.82465 1 0.49845 1 0.46888 1 0.26082 1 0.43855 1 ZNF517 13 (21%) 49 0.94522 1 0.73365 1 NA NA NA NA 0.82273 1 0.95244 1 0.27516 1 0.69418 1 0.86137 1 0.46074 1 MAL2 11 (18%) 51 0.91536 1 0.079519 1 0.28498 1 1 1 0.31397 1 0.51093 1 0.70705 1 0.26686 1 0.81159 1 0.50557 1 TOR3A 12 (19%) 50 0.19018 1 0.30736 1 0.1117 1 0.31265 1 0.55577 1 0.0050799 1 1 1 0.84243 1 0.62579 1 0.66614 1 TP53 13 (21%) 49 0.14059 1 0.34611 1 0.27524 1 0.60123 1 0.02993 1 0.32228 1 0.02428 1 0.59641 1 0.03323 1 0.083369 1 CLDN23 10 (16%) 52 0.22506 1 0.4032 1 1 1 0.34848 1 0.03533 1 0.2117 1 0.34491 1 0.18125 1 0.50672 1 0.30669 1 GDF1 5 (8%) 57 0.0265 1 0.13998 1 NA NA NA NA 0.44155 1 0.35398 1 0.23826 1 0.51149 1 0.47328 1 0.60526 1 LZTR1 6 (10%) 56 0.02105 1 0.9426 1 NA NA NA NA 0.13178 1 0.1175 1 0.18265 1 0.01468 1 0.38709 1 0.066059 1 ANKRD43 19 (31%) 43 0.377 1 0.17433 1 0.48078 1 0.59898 1 0.26756 1 0.22552 1 0.56533 1 0.10257 1 0.5206 1 0.59592 1 KCNK17 9 (15%) 53 0.15568 1 0.01034 1 0.37555 1 0.44037 1 0.074009 1 0.0095299 1 0.79715 1 0.54569 1 0.40523 1 0.56742 1 RINL 8 (13%) 54 0.32644 1 0.96235 1 0.074919 1 0.57853 1 0.47646 1 0.27508 1 0.26779 1 0.16861 1 0.098039 1 0.36163 1 ZAR1 11 (18%) 51 0.20926 1 0.29784 1 0.2292 1 0.79311 1 0.50704 1 0.86978 1 0.42809 1 0.97039 1 0.3001 1 0.70094 1 CTNNB1 8 (13%) 54 0.64145 1 0.32004 1 0.11162 1 0.3128 1 0.0085199 1 0.0060499 1 0.0052499 1 0.16741 1 0.04287 1 0.40349 1 APOE 7 (11%) 55 0.11114 1 0.70699 1 0.46716 1 0.38286 1 0.03756 1 0.39998 1 0.65151 1 0.79038 1 0.17058 1 0.92146 1 GPRIN2 8 (13%) 54 0.52638 1 0.17781 1 0.22688 1 0.69217 1 0.74485 1 0.39952 1 0.87997 1 0.75297 1 0.62655 1 0.50167 1 ASPDH 8 (13%) 54 0.28227 1 0.29925 1 0.71279 1 0.31377 1 0.0090299 1 0.3983 1 0.31368 1 0.03239 1 0.070229 1 0.01477 1 ERCC2 10 (16%) 52 0.21417 1 0.11681 1 0.095429 1 0.23282 1 0.50911 1 0.17185 1 0.38099 1 0.26848 1 0.37974 1 0.4886 1 IDUA 8 (13%) 54 0.0199 1 0.52632 1 0.81789 1 0.79131 1 0.57051 1 0.54561 1 0.68749 1 0.43228 1 0.81902 1 0.47617 1 C1ORF106 9 (15%) 53 0.40649 1 0.49655 1 0.26499 1 0.04808 1 0.41217 1 0.76231 1 0.6266 1 0.69139 1 0.59933 1 0.98759 1 C10ORF95 6 (10%) 56 0.23707 1 0.69127 1 NA NA NA NA 0.60612 1 1 1 0.60988 1 0.35873 1 0.7718 1 0.78333 1 RGS9BP 8 (13%) 54 0.20208 1 0.57782 1 0.87913 1 0.12769 1 1 1 0.93466 1 0.23564 1 0.96255 1 0.5607 1 0.25443 1 THEM4 5 (8%) 57 0.12396 1 0.2141 1 NA NA NA NA 0.44125 1 0.87569 1 0.53894 1 0.10672 1 0.51284 1 0.30367 1 TSC22D2 8 (13%) 54 0.65984 1 0.26518 1 0.67383 1 0.95508 1 0.68282 1 0.81663 1 0.87832 1 0.4297 1 0.62453 1 0.67125 1 SYT8 8 (13%) 54 0.17399 1 0.30519 1 0.46765 1 1 1 0.064429 1 0.17528 1 1 1 0.18389 1 0.63277 1 0.7048 1 PLIN5 5 (8%) 57 0.8963 1 0.75255 1 0.30934 1 0.38185 1 0.79725 1 0.66739 1 0.72096 1 0.26591 1 0.85659 1 0.31216 1 LRIG1 16 (26%) 46 0.44847 1 0.64883 1 0.28256 1 1 1 0.87069 1 0.61113 1 0.58648 1 0.43211 1 0.69415 1 0.98454 1 HHIPL1 6 (10%) 56 0.15129 1 0.57631 1 NA NA NA NA 0.56636 1 0.51247 1 0.35981 1 0.42528 1 0.050789 1 0.29794 1 CCDC105 6 (10%) 56 0.83732 1 0.076319 1 0.46625 1 0.67328 1 0.93288 1 0.79269 1 0.86524 1 0.054569 1 0.33323 1 0.15325 1 C19ORF10 7 (11%) 55 0.76012 1 0.23094 1 0.81857 1 0.3917 1 0.28962 1 0.12539 1 0.65568 1 0.86499 1 0.34829 1 0.86211 1 OPRD1 12 (19%) 50 0.90671 1 0.58171 1 0.22857 1 0.48103 1 0.82645 1 0.96003 1 0.4938 1 0.6147 1 0.50475 1 0.52481 1 ATXN1 10 (16%) 52 0.44961 1 0.02952 1 0.1482 1 0.91588 1 0.13969 1 0.656 1 0.4288 1 0.87018 1 0.04684 1 0.59422 1 AATK 6 (10%) 56 0.098409 1 0.31565 1 NA NA NA NA 0.22518 1 0.35492 1 1 1 0.54455 1 0.77077 1 0.7407 1 ZNF628 7 (11%) 55 0.77935 1 0.85044 1 1 1 0.67452 1 0.28081 1 0.11329 1 0.49889 1 0.50304 1 0.14981 1 0.66978 1 KRTAP4-5 5 (8%) 57 0.76965 1 0.82446 1 NA NA NA NA 0.90539 1 0.87571 1 1 1 0.84242 1 1 1 0.96532 1 NOXA1 5 (8%) 57 0.15545 1 0.74119 1 NA NA NA NA 0.23994 1 0.44233 1 0.10308 1 0.34967 1 0.19323 1 0.15442 1 TRIOBP 10 (16%) 52 0.90478 1 0.41865 1 0.46357 1 0.12881 1 1 1 0.11143 1 0.53287 1 0.86935 1 0.45679 1 0.89107 1 ZNF598 12 (19%) 50 0.64893 1 0.77274 1 0.58641 1 0.74832 1 0.82305 1 0.95242 1 0.90137 1 0.22711 1 0.1772 1 0.24966 1 IRX3 5 (8%) 57 0.31716 1 0.43606 1 NA NA NA NA 0.53164 1 0.11763 1 0.54002 1 0.78074 1 0.16986 1 0.082949 1 WDR34 5 (8%) 57 0.19356 1 0.89768 1 NA NA NA NA 0.85792 1 0.81619 1 0.60599 1 0.55101 1 0.22292 1 0.097189 1 BHLHE22 5 (8%) 57 0.9431 1 0.29444 1 0.8162 1 0.91631 1 0.04595 1 0.81196 1 1 1 0.83545 1 0.59281 1 0.81683 1 PANK2 5 (8%) 57 0.76789 1 0.79458 1 0.5858 1 0.3476 1 0.079289 1 0.050019 1 0.76721 1 0.35098 1 0.01758 1 0.30483 1 FPGS 5 (8%) 57 0.57276 1 0.090389 1 0.46807 1 0.34922 1 0.68555 1 0.59779 1 0.23833 1 0.62507 1 0.65872 1 0.88008 1 GLTPD2 6 (10%) 56 0.098899 1 0.82644 1 NA NA NA NA 0.82982 1 0.39934 1 0.86636 1 0.53283 1 0.33384 1 0.22792 1 TNIP2 5 (8%) 57 0.84479 1 0.4246 1 NA NA NA NA 0.74594 1 0.87538 1 0.82283 1 0.41346 1 0.60766 1 0.26506 1 AKAP2 6 (10%) 56 0.070939 1 0.82449 1 0.91701 1 0.75521 1 0.82938 1 0.59267 1 0.65632 1 0.28149 1 0.93953 1 0.70741 1 RREB1 5 (8%) 57 0.2778 1 0.85962 1 NA NA NA NA 0.61892 1 1 1 0.23595 1 0.54576 1 0.28557 1 0.48949 1 TPO 12 (19%) 50 0.2828 1 0.52663 1 0.88593 1 0.69298 1 0.22082 1 0.12495 1 0.2213 1 0.3423 1 0.47663 1 0.19547 1 OBSCN 18 (29%) 44 0.96346 1 0.33994 1 0.89135 1 0.54522 1 0.56802 1 0.80753 1 0.21911 1 0.49674 1 0.95591 1 0.56283 1 SNED1 5 (8%) 57 0.31571 1 0.89892 1 NA NA NA NA 0.43905 1 0.66762 1 0.03268 1 0.66167 1 0.29753 1 0.88045 1 MEN1 5 (8%) 57 0.2854 1 0.01784 1 NA NA NA NA 0.0189 1 0.0065899 1 0.17358 1 0.04278 1 0.02407 1 0.075459 1 BTBD11 6 (10%) 56 1 1 0.88448 1 NA NA NA NA 0.79806 1 1 1 0.17439 1 0.18369 1 0.34278 1 0.2367 1 RNF149 4 (6%) 58 0.21491 1 0.060759 1 0.67473 1 0.95362 1 0.43902 1 0.60067 1 0.82162 1 0.25994 1 0.60571 1 0.55265 1 KIAA1984 4 (6%) 58 0.1488 1 0.11692 1 1 1 0.50595 1 0.10255 1 0.04961 1 0.18033 1 0.58401 1 0.38871 1 0.96657 1 CCDC150 4 (6%) 58 0.53695 1 0.58069 1 1 1 0.60186 1 0.17761 1 0.11703 1 0.53502 1 0.20987 1 0.16944 1 0.29927 1 FAM18B2 4 (6%) 58 0.22984 1 0.96559 1 NA NA NA NA 0.22272 1 0.48117 1 0.097289 1 0.50971 1 0.02857 1 0.60301 1 MUC5B 22 (35%) 40 0.9973 1 0.13312 1 0.53838 1 0.81241 1 0.77008 1 0.67007 1 0.93605 1 0.61673 1 0.87443 1 0.96726 1 PTPLA 4 (6%) 58 0.23062 1 0.44439 1 NA NA NA NA 0.61728 1 0.4407 1 1 1 1 1 0.19287 1 0.49665 1 SRPX 3 (5%) 59 0.66139 1 0.44383 1 NA NA NA NA 0.61747 1 1 1 1 1 0.71785 1 1 1 0.84861 1 GARS 19 (31%) 43 0.4308 1 0.22848 1 0.51743 1 0.33511 1 0.30784 1 0.10161 1 0.074439 1 0.40265 1 0.17418 1 0.4843 1 PRSS27 3 (5%) 59 0.086469 1 0.73999 1 NA NA NA NA 0.12742 1 0.050239 1 0.49947 1 1 1 0.69035 1 0.49291 1 SEMA5B 8 (13%) 54 0.12837 1 0.53357 1 0.58763 1 0.17476 1 0.46145 1 0.21353 1 0.48605 1 0.29818 1 0.44387 1 0.60256 1 CD320 4 (6%) 58 0.96828 1 1 1 NA NA NA NA 1 1 0.65386 1 0.36674 1 0.22457 1 0.11076 1 0.2274 1 TAF5 4 (6%) 58 0.96703 1 1 1 0.31004 1 0.95426 1 1 1 0.87571 1 0.099489 1 0.1155 1 0.4693 1 0.16676 1 NEFH 6 (10%) 56 0.64002 1 0.36577 1 NA NA NA NA 0.079239 1 0.051049 1 0.53519 1 0.21125 1 0.00318 1 0.18244 1 DMKN 3 (5%) 59 0.099739 1 0.44084 1 NA NA NA NA 0.6173 1 0.44314 1 0.051199 1 0.57074 1 0.12037 1 0.89258 1 NPTX1 3 (5%) 59 0.25596 1 0.5504 1 NA NA NA NA 1 1 0.81224 1 0.27695 1 0.79567 1 0.48499 1 0.76172 1 NOTCH2 5 (8%) 57 0.03152 1 0.82256 1 NA NA NA NA 0.52842 1 0.11881 1 0.01402 1 0.31869 1 0.02872 1 0.55445 1 RNF39 5 (8%) 57 0.78775 1 0.41056 1 0.074429 1 0.79361 1 0.14646 1 0.26343 1 0.3593 1 0.70299 1 0.38476 1 0.50856 1 KBTBD13 9 (15%) 53 0.76755 1 0.40281 1 0.48851 1 0.79294 1 0.70859 1 0.1176 1 0.53425 1 0.33098 1 0.66103 1 0.90487 1 IER5 3 (5%) 59 0.2593 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA SCRT1 3 (5%) 59 0.94197 1 0.59292 1 NA NA NA NA 0.46801 1 0.61762 1 0.76821 1 0.795 1 0.36923 1 1 1 KNDC1 9 (15%) 53 0.66854 1 0.01582 1 0.58593 1 0.55496 1 0.04098 1 0.32666 1 0.51629 1 0.3652 1 0.36183 1 0.5492 1 MAP1S 5 (8%) 57 0.51587 1 0.36393 1 0.28516 1 0.41691 1 0.44444 1 1 1 1 1 0.83577 1 1 1 0.81644 1 RGMB 6 (10%) 56 0.3669 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA LRP11 6 (10%) 56 0.32062 1 0.38834 1 NA NA NA NA 0.79819 1 0.66572 1 1 1 0.93553 1 0.92382 1 0.59469 1 AR 4 (6%) 58 0.30755 1 0.28219 1 1 1 0.9544 1 0.46698 1 0.44407 1 0.77086 1 1 1 0.19205 1 1 1 VARS 6 (10%) 56 0.54405 1 0.35901 1 0.31062 1 0.38075 1 0.48307 1 0.067699 1 1 1 0.86115 1 0.83627 1 1 1 SEZ6L2 8 (13%) 54 0.65582 1 0.143 1 0.87982 1 0.78795 1 0.83074 1 1 1 0.86598 1 0.62782 1 1 1 0.57593 1 PABPC1 4 (6%) 58 0.33073 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA FANK1 3 (5%) 59 1 1 0.051779 1 NA NA NA NA 0.86554 1 0.28794 1 0.27912 1 0.23248 1 0.27976 1 0.03672 1 NMU 5 (8%) 57 0.33211 1 0.8407 1 NA NA NA NA 0.12528 1 0.61697 1 0.82267 1 0.54478 1 1 1 0.15965 1 ADAD2 4 (6%) 58 0.19145 1 0.48016 1 NA NA NA NA 0.74605 1 0.17323 1 0.097869 1 0.51003 1 0.4686 1 0.87877 1 CLIC6 5 (8%) 57 0.22784 1 0.43418 1 NA NA NA NA 0.68484 1 0.1179 1 0.18483 1 0.58374 1 0.04871 1 0.96719 1 PCDHB13 5 (8%) 57 0.52923 1 0.02808 1 NA NA NA NA 0.44072 1 0.35574 1 0.37005 1 0.059589 1 0.12942 1 0.095719 1 PLEC 13 (21%) 49 0.68779 1 0.2018 1 0.11119 1 0.04722 1 0.1413 1 0.71966 1 0.6247 1 0.6316 1 0.3498 1 0.062589 1 AMDHD1 10 (16%) 52 0.28428 1 0.66972 1 1 1 0.34984 1 0.59082 1 0.13634 1 0.72992 1 0.85328 1 0.54064 1 0.87991 1 DSPP 9 (15%) 53 0.11997 1 0.15875 1 0.23042 1 0.69196 1 1 1 0.48348 1 0.72899 1 0.53954 1 0.42743 1 0.35501 1 TMEM189 3 (5%) 59 0.7828 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA CRIPAK 10 (16%) 52 0.12966 1 0.52986 1 0.8192 1 0.9336 1 0.4229 1 0.68975 1 0.35043 1 0.32777 1 0.49313 1 0.44621 1 PDCD6 3 (5%) 59 0.60636 1 0.64258 1 NA NA NA NA NA NA NA NA 1 1 0.63941 1 1 1 0.68577 1 MAP7 3 (5%) 59 0.85743 1 0.82603 1 NA NA NA NA 1 1 0.81289 1 0.49805 1 0.79318 1 0.48125 1 0.76531 1 NOM1 6 (10%) 56 0.63894 1 0.88538 1 NA NA NA NA 0.64658 1 1 1 1 1 0.78751 1 1 1 0.15969 1 SHOX2 3 (5%) 59 0.04347 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA HSD17B1 4 (6%) 58 0.45633 1 0.47901 1 0.87833 1 0.50662 1 0.90519 1 0.0078199 1 0.82431 1 0.84042 1 1 1 0.31234 1 PRKAR1A 6 (10%) 56 0.83815 1 0.47058 1 0.82007 1 0.79215 1 0.22806 1 0.39818 1 0.16896 1 0.58747 1 0.088339 1 0.18003 1 KRTAP5-5 3 (5%) 59 0.063629 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA DLEU7 3 (5%) 59 0.71492 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA FEZ2 3 (5%) 59 0.8551 1 0.04022 1 NA NA NA NA 0.23974 1 0.81452 1 0.2795 1 0.79056 1 0.48461 1 0.49687 1 RASIP1 6 (10%) 56 0.063419 1 0.18101 1 NA NA NA NA 0.0028 1 0.18947 1 0.11655 1 0.69847 1 0.04345 1 0.73884 1 JMJD4 3 (5%) 59 0.49789 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA COQ2 5 (8%) 57 0.13276 1 0.085019 1 NA NA NA NA 0.44169 1 0.60261 1 1 1 0.66913 1 0.7699 1 0.4913 1 UQCRFS1 5 (8%) 57 0.62253 1 0.45202 1 NA NA NA NA 1 1 0.87677 1 0.6091 1 0.20258 1 0.59324 1 0.11798 1 C9ORF66 5 (8%) 57 0.40709 1 1 1 NA NA NA NA 0.36787 1 0.51389 1 1 1 0.9358 1 0.92295 1 0.88216 1 POLRMT 4 (6%) 58 0.51722 1 0.083969 1 0.10799 1 0.34944 1 0.36893 1 0.058129 1 0.18294 1 0.26205 1 0.23364 1 0.55047 1 ADAMTS7 4 (6%) 58 0.01008 1 0.72162 1 0.0276 1 0.35125 1 0.13149 1 0.4384 1 0.1007 1 0.26314 1 0.20918 1 0.34923 1 BTNL9 4 (6%) 58 0.056559 1 0.18004 1 NA NA NA NA 0.15295 1 0.096549 1 0.49431 1 1 1 0.69019 1 1 1 NF1 7 (11%) 55 0.33585 1 0.82788 1 0.81869 1 0.39164 1 0.31389 1 0.19016 1 0.87685 1 0.88348 1 0.04946 1 0.4175 1 ZNF814 3 (5%) 59 0.94304 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA RNF135 3 (5%) 59 0.7166 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA CSGALNACT2 3 (5%) 59 0.85591 1 0.22085 1 NA NA NA NA 0.772 1 0.81565 1 0.27944 1 0.87393 1 0.48163 1 0.94155 1 SPIRE2 3 (5%) 59 0.94217 1 0.13079 1 NA NA NA NA 1 1 0.81189 1 0.76764 1 0.79348 1 0.54428 1 1 1 CYP4A22 4 (6%) 58 0.15217 1 0.82369 1 NA NA NA NA 0.22392 1 0.48466 1 0.18187 1 0.19891 1 0.04815 1 0.87929 1 HLA-A 3 (5%) 59 0.71753 1 0.94985 1 NA NA NA NA 0.8657 1 0.19595 1 0.76758 1 0.51004 1 1 1 0.34732 1 GLI3 5 (8%) 57 0.12586 1 0.6231 1 NA NA NA NA 0.90668 1 0.87596 1 0.36995 1 0.4139 1 0.51194 1 0.13767 1