rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(3), CD3G(3)	1708219	6	6	6	0	0	2	1	2	1	0	0.271	0.0958	1.000
2	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(1)	3044170	6	6	6	1	2	1	0	2	1	0	0.484	0.367	1.000
3	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	739599	1	1	1	0	0	0	0	1	0	0	0.800	0.391	1.000
4	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3E(3), CD3G(3), CD4(4)	4752811	13	12	13	3	1	3	2	3	4	0	0.519	0.456	1.000
5	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8)	7947000	13	13	13	1	2	4	1	3	3	0	0.138	0.474	1.000
6	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	9	B3GALT1(3), B3GALT2(2), B3GALT5(2), B3GNT5(4), FUT1(1), FUT3(3), ST3GAL3(4), ST3GAL4(2)	9411230	21	18	21	2	5	6	7	3	0	0	0.0487	0.492	1.000
7	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(3)	2944424	9	9	9	2	1	4	2	2	0	0	0.487	0.511	1.000
8	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	6	CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), TFDP1(3)	7066982	15	15	14	3	4	3	2	1	5	0	0.516	0.531	1.000
9	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), STAT1(4)	12001014	26	24	26	2	2	5	6	5	8	0	0.0771	0.536	1.000
10	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(1), HGD(4)	3252093	7	7	7	2	1	0	2	3	1	0	0.708	0.557	1.000
11	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	10	CCNE1(2), CDK2(2), CKS1B(1), CUL1(2), E2F1(5), NEDD8(1), SKP2(2), TFDP1(3)	9342168	18	18	17	3	4	6	2	2	4	0	0.362	0.578	1.000
12	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(11), BAD(1), BAK1(3), BAX(3), BCL10(3), BCL2L1(1), BCL2L11(4), BID(3), CASP9(2), CES1(4)	10869574	35	28	35	5	6	16	4	4	5	0	0.0991	0.578	1.000
13	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(1), DAB1(5), LRP8(6), RELN(26), VLDLR(9)	20137509	49	38	47	4	8	12	12	7	9	1	0.00616	0.578	1.000
14	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CCNH(2), CDC25A(1), CDC25B(3), CDC25C(4), CDK7(3), MNAT1(2), SHH(1), XPO1(15)	12412367	34	28	33	4	8	16	3	2	5	0	0.0741	0.579	1.000
15	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(4), HLCS(3), SPCS3(1)	4480610	8	8	8	0	1	5	2	0	0	0	0.0842	0.609	1.000
16	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(2), GOT2(1), TAT(3), TYR(5)	6781413	14	13	14	3	3	2	5	2	2	0	0.505	0.624	1.000
17	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	1048037	1	1	1	1	0	0	0	0	1	0	0.943	0.641	1.000
18	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(1), TAT(3)	3784360	6	5	6	1	1	1	1	1	2	0	0.642	0.645	1.000
19	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(2), CD4(4), HLA-DRB1(10)	2584921	16	15	16	8	1	2	5	4	4	0	0.911	0.656	1.000
20	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), CREM(2), FHL5(3), FSHR(9), GNAS(11), XPO1(15)	12910772	45	36	44	8	11	9	9	10	6	0	0.246	0.683	1.000
21	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(3), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1)	10303281	23	21	23	3	5	4	4	6	4	0	0.224	0.693	1.000
22	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), SKP2(2), TFDP1(3)	9891250	17	17	16	3	4	5	2	1	5	0	0.401	0.709	1.000
23	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(4), ITPKA(1), PDE1A(5), PDE1B(5), PLCB1(12), PLCB2(7), TRH(1), VIP(1)	15499132	41	32	41	5	6	11	6	9	9	0	0.0701	0.722	1.000
24	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	2287685	3	3	3	1	0	1	1	0	1	0	0.761	0.749	1.000
25	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(1), GNB1(2), HTR2C(5), PLCB1(12), TUB(4)	10158106	28	23	28	5	8	5	3	6	6	0	0.211	0.780	1.000
26	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(11), GNB1(2), PRKACA(3), PRKAR1A(4)	8511207	25	23	25	5	7	4	4	5	5	0	0.412	0.785	1.000
27	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(7), DNAJC3(4), EIF2S1(3), EIF2S2(3), NFKB1(5), NFKBIA(3), RELA(3)	13263979	28	24	28	4	10	9	4	2	3	0	0.144	0.814	1.000
28	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(4), SNAP25(3), STX1A(2), VAMP2(1)	4605994	14	12	14	4	3	5	2	3	1	0	0.541	0.815	1.000
29	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(3), BIK(1), BIRC2(3), BIRC3(4), CASP3(1), CASP6(2), CASP7(2), CASP9(2), DFFA(4), DFFB(2), DIABLO(1)	17643439	43	31	42	3	3	20	7	3	10	0	0.0156	0.825	1.000
30	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(2), CCND1(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(1), CFL1(1), E2F1(5), E2F2(1), MDM2(3), PRB1(3)	9433186	21	21	20	4	5	1	2	3	10	0	0.469	0.825	1.000
31	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(1)	2465890	4	4	4	2	0	0	0	2	2	0	0.916	0.825	1.000
32	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOA(5), ALDOB(3), ALDOC(2), TPI1(2)	5549039	13	13	13	3	2	7	1	1	2	0	0.375	0.829	1.000
33	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(1), CCR3(2), HLA-DRB1(10), IL3(1)	3491516	14	13	14	6	1	2	4	4	3	0	0.863	0.831	1.000
34	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(6), MAX(2), MYC(1), SP1(6), SP3(7), WT1(3)	8590864	25	23	24	5	5	5	2	6	7	0	0.382	0.833	1.000
35	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(3), B4GALT3(2), B4GALT5(4), FUT8(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(4), ST3GAL4(2)	10975810	23	20	23	4	3	9	5	3	3	0	0.221	0.837	1.000
36	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(23), CDC25A(1), CDC25B(3), CDC25C(4), CDK2(2), CDK4(1), CHEK1(2), MYT1(10), WEE1(4)	21918715	50	45	49	7	5	18	4	10	13	0	0.173	0.843	1.000
37	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(5), IDI1(5), SQLE(2)	4788842	16	15	15	4	3	6	3	1	3	0	0.627	0.845	1.000
38	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYB(1), NFYC(3), SP1(6), SP3(7)	7102782	17	17	16	4	0	4	2	5	6	0	0.636	0.855	1.000
39	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(8), LARS(5), LARS2(3), PDHA1(3), PDHA2(4), PDHB(1)	14627323	28	25	28	4	3	10	6	5	4	0	0.133	0.867	1.000
40	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3), SLPI(1)	2295771	4	4	4	2	0	0	3	1	0	0	0.867	0.867	1.000
41	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1)	7671895	14	14	14	3	2	3	4	3	2	0	0.447	0.871	1.000
42	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(1), NR3C1(3), PPARG(5), RXRA(2)	7587876	14	14	13	3	3	2	4	2	3	0	0.452	0.873	1.000
43	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(2), PAPSS2(2), SULT1A2(2), SULT1E1(3), SUOX(4)	8888263	15	13	15	3	3	3	4	3	2	0	0.513	0.883	1.000
44	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	12847026	32	30	31	6	4	12	8	5	3	0	0.116	0.889	1.000
45	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	12847026	32	30	31	6	4	12	8	5	3	0	0.116	0.889	1.000
46	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(6), GAD1(3), PNMT(1), TH(2), TPH1(2)	7970227	14	13	14	3	5	3	2	1	3	0	0.398	0.890	1.000
47	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	18	AKT1(2), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), E2F1(5), HRAS(2), MAPK1(1), MAPK3(1), NFKB1(5), NFKBIA(3), PAK1(3), RAF1(4), RELA(3), TFDP1(3)	20158373	41	37	40	6	12	8	5	8	8	0	0.0759	0.896	1.000
48	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(23), CDC25A(1), CDC25B(3), CDC25C(4), CHEK1(2), MYT1(10), WEE1(4)	20101230	47	42	46	7	5	18	4	9	11	0	0.210	0.898	1.000
49	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), ACP5(3), ACPP(6), ACPT(1), ENPP1(7), ENPP3(5), FLAD1(7), RFK(1), TYR(5)	14087489	36	32	35	6	7	8	10	6	5	0	0.124	0.899	1.000
50	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(3), GLS(4), GLUD1(2), OAT(2), PRODH(2)	7882934	16	12	16	2	1	5	2	3	5	0	0.318	0.904	1.000
51	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(2), CD4(4), HLA-DRB1(10), IL4(1)	4898108	17	16	17	9	1	2	5	4	5	0	0.958	0.905	1.000
52	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(5), CBS(1), CTH(3), MUT(3)	6903634	13	13	13	3	2	3	2	2	4	0	0.524	0.909	1.000
53	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2)	8282627	9	9	9	2	2	2	5	0	0	0	0.509	0.914	1.000
54	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ6(4)	6029332	7	7	7	0	1	3	2	1	0	0	0.169	0.919	1.000
55	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(3), HK2(5), HK3(5), PGM1(5), PGM3(2), TGDS(3)	14562762	26	23	26	4	4	3	5	9	5	0	0.139	0.920	1.000
56	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(2), CHKA(1), PCYT1A(2), PDHA1(3), PDHA2(4), PEMT(1), SLC18A3(3)	9265911	19	17	19	4	5	4	4	4	2	0	0.304	0.920	1.000
57	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(3), CD3G(3), CXCR3(6), ETV5(8), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), JAK2(7), JUN(3), MAP2K6(1), MAPK14(1), MAPK8(2), STAT4(8), TYK2(7)	27038005	71	59	69	11	11	17	11	17	15	0	0.0648	0.923	1.000
58	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(5), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD17B4(8), HSD3B1(3), HSD3B2(4)	11647324	30	30	29	7	2	8	10	6	4	0	0.425	0.926	1.000
59	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(11), ATM(23), BAX(3), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(5), MDM2(3), TIMP3(3)	22234884	55	46	54	9	9	15	5	9	17	0	0.242	0.929	1.000
60	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(3), FARSB(5), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4), YARS2(1)	12545778	26	20	26	4	3	11	3	5	4	0	0.211	0.941	1.000
61	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	14	ACE(11), CD44(3), CSF1(5), FCGR3A(3), IL6R(4), SELL(6), SPN(2), TGFB1(2), TGFB2(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(4)	18003567	47	36	45	8	7	12	5	11	12	0	0.103	0.943	1.000
62	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	22	ATF1(3), CASP2(3), CHUK(7), IKBKB(5), JUN(3), LTA(2), MAP2K3(3), MAP2K6(1), MAP4K2(2), MAPK14(1), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFRSF1A(4), TRAF2(1)	28606815	56	48	55	7	12	17	9	7	11	0	0.0155	0.944	1.000
63	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(3), ASL(4), CPS1(12), GLS(4), GLUD1(2), GOT1(2)	11122150	27	22	27	5	0	5	11	6	5	0	0.355	0.944	1.000
64	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(7)	14840467	37	33	35	7	3	4	12	8	10	0	0.369	0.945	1.000
65	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(7)	14840467	37	33	35	7	3	4	12	8	10	0	0.369	0.945	1.000
66	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(3), CDK7(3), CDKN1A(1), CHEK1(2), NEK1(6), WEE1(4)	11040121	20	18	20	3	3	9	0	1	7	0	0.515	0.946	1.000
67	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(5), MST1R(8)	8256780	14	11	14	2	3	8	1	1	1	0	0.202	0.946	1.000
68	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(7), ALOX15(4), ALOX15B(5), ALOX5(3), ALOX5AP(1), DPEP1(2), GGT1(4), LTA4H(2), PLA2G2A(1), PLA2G6(1), PTGDS(2), PTGIS(4), PTGS1(5), PTGS2(6), TBXAS1(3)	21320989	50	39	50	7	10	11	12	9	8	0	0.0175	0.953	1.000
69	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(4), LCT(17), MPI(2), PGM1(5), PYGL(3), PYGM(5), TPI1(2), TREH(2)	19348985	43	39	43	8	8	7	8	9	11	0	0.137	0.961	1.000
70	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(6), AOC3(3), CES1(4), ESD(2)	8189386	15	11	15	4	1	3	6	3	2	0	0.505	0.962	1.000
71	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(11), JAK2(7), JAK3(8), MAPK1(1), MAPK3(1), STAT3(5), TYK2(7)	16432080	40	34	38	7	8	5	9	7	11	0	0.215	0.964	1.000
72	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BAG4(1), BIRC3(4), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	8868514	17	15	16	4	4	7	3	0	3	0	0.465	0.966	1.000
73	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(5), NFKBIA(3), PLCB1(12), PRKCA(4), RELA(3)	11785977	28	23	28	5	6	4	4	6	8	0	0.291	0.966	1.000
74	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(2), CD3E(3), CD3G(3), CD4(4), CD58(2), CD8A(3), CSF3(2), IL3(1), IL6(1), KITLG(3)	9045178	28	26	28	7	2	10	6	4	6	0	0.401	0.971	1.000
75	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(3), UGDH(1), UGP2(4), UXS1(3)	7322449	12	11	12	3	2	7	1	1	1	0	0.578	0.971	1.000
76	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	CASP3(1), CFL1(1), CFLAR(1)	3767259	3	3	3	1	0	0	1	1	1	0	0.772	0.974	1.000
77	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(4), CHUK(7), IFNG(2), IKBKB(5), IL4(1), JUN(3), MAP3K5(12), MAP4K5(1), MAPK14(1), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), TNFRSF9(2), TNFSF9(1), TRAF2(1)	24422437	53	43	52	9	14	14	7	5	13	0	0.148	0.975	1.000
78	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(2), FARS2(4), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4)	11963381	20	15	20	3	3	5	5	4	3	0	0.216	0.975	1.000
79	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(1), FUT3(3), FUT5(2), FUT6(3), ST3GAL3(4)	6006817	13	13	13	4	4	2	4	2	1	0	0.535	0.975	1.000
80	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TPO(7), TYR(5)	13832951	33	30	33	7	7	7	6	6	7	0	0.273	0.977	1.000
81	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), PLA2G2A(1), PTPRU(10), REG1A(1), STAT1(4)	16474611	40	35	40	8	5	7	9	7	11	1	0.352	0.977	1.000
82	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), CDKN1A(1), EPO(1), EPOR(4), GRIN1(3), HIF1A(4), JAK2(7), NFKB1(5), NFKBIA(3), RELA(3)	17979768	35	31	35	5	6	13	3	5	8	0	0.118	0.978	1.000
83	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(11), AGT(3), AGTR1(4), AGTR2(2), BDKRB2(4), KNG1(4), NOS3(3), REN(1)	13603266	32	28	32	7	7	10	5	6	4	0	0.201	0.981	1.000
84	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), CKM(1), FBL(5), GPT(2), LDHA(2), LDHC(4), MAPK14(1), NCL(7)	13013931	30	27	30	6	5	9	7	4	5	0	0.315	0.981	1.000
85	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11A1(1), CYP11B2(4), CYP17A1(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	9799872	23	22	22	6	2	7	6	6	2	0	0.322	0.983	1.000
86	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(3), HK2(5), HK3(5), IMPA2(4), ISYNA1(1), PGM1(5), PGM3(2), TGDS(3)	16304414	31	27	31	5	6	3	6	10	6	0	0.112	0.983	1.000
87	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1A(1), BMPR1B(6), BMPR2(8)	8801986	18	16	17	7	1	2	4	5	6	0	0.893	0.983	1.000
88	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(3), CSF1(5), CSF3(2), EPO(1), IL11(1), IL3(1), IL4(1), IL6(1), IL7(1)	8731251	20	19	20	5	3	7	4	1	5	0	0.424	0.984	1.000
89	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(4), CTH(3), GOT1(2), GOT2(1), LDHA(2), LDHC(4)	9369561	16	15	16	4	0	6	2	2	6	0	0.596	0.985	1.000
90	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), CHST1(4), CHST2(4), CHST4(1), FUT8(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(4), ST3GAL4(2)	15878410	34	31	34	6	9	8	7	5	5	0	0.127	0.986	1.000
91	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(10), BAIAP2(2), CASP1(3), CASP3(1), CASP7(2), GAPDH(1), INSR(11), ITCH(4), MAGI1(15), MAGI2(9), RERE(12), WWP1(6), WWP2(12)	31694828	88	59	85	12	12	34	12	21	8	1	0.00812	0.987	1.000
92	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(5), B4GALT1(3), B4GALT3(2), B4GALT5(4), DDOST(2), DPAGT1(3), DPM1(4), FUT8(3), MAN1A1(6), MAN1B1(3), MGAT3(4), MGAT4A(3), MGAT4B(4), MGAT5(3), RPN1(4), RPN2(2), ST6GAL1(3)	26669546	59	41	59	9	8	18	13	10	9	1	0.0399	0.987	1.000
93	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(2), IFNG(2), IFNGR1(2), IKBKB(5), JAK2(7), LIN7A(1), NFKB1(5), NFKBIA(3), RELA(3), TNFRSF1A(4), TNFRSF1B(2), USH1C(5), WT1(3)	21267731	44	35	43	7	11	11	5	5	12	0	0.0743	0.988	1.000
94	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(1), EGR1(3), HRAS(2), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NGFR(1), RAF1(4)	11233373	25	23	24	5	4	7	2	6	6	0	0.262	0.989	1.000
95	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(5), CDO1(3), CSAD(5), GAD1(3), GAD2(3), GGT1(4)	8099282	23	21	23	6	3	10	4	2	4	0	0.438	0.990	1.000
96	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(2), DFFA(4), DFFB(2), HMGB1(2), HMGB2(3), TOP2A(3), TOP2B(6)	15309441	23	17	22	2	0	10	3	5	5	0	0.162	0.991	1.000
97	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(3), PRKCA(4), TGM2(7)	6999927	15	13	15	7	3	4	1	1	6	0	0.857	0.992	1.000
98	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(3), RAB1A(2), RAB27A(1), RAB3A(2), RAB6A(4), RAB9A(1)	6242988	16	15	16	5	1	6	4	1	3	1	0.717	0.993	1.000
99	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PNPO(2), PSAT1(1)	6836222	10	9	10	3	2	2	2	1	3	0	0.660	0.993	1.000
100	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(2), MDH1(1), PC(10), PDHA1(3), SLC25A1(2), SLC25A11(2)	13022183	29	26	29	7	4	3	10	5	7	0	0.352	0.993	1.000
101	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(4), BLVRB(1), IL10RA(1), IL10RB(3), IL1A(1), IL6(1), JAK1(11), STAT1(4), STAT3(5), STAT5A(6)	17103884	37	32	37	7	5	8	9	9	6	0	0.171	0.994	1.000
102	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	17	BAD(1), BAX(3), MAP2K1(5), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(5), NSMAF(3), RAF1(4), RELA(3), RIPK1(5), SMPD1(2), TNFRSF1A(4), TRAF2(1)	21736420	40	31	39	5	9	15	3	5	8	0	0.0316	0.995	1.000
103	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3G(3)	10670671	17	14	17	4	4	4	4	2	3	0	0.490	0.995	1.000
104	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(3), CREBBP(15), DFFA(4), DFFB(2), GZMA(3), HMGB2(3), PRF1(2)	15299382	34	29	33	7	6	7	6	5	10	0	0.355	0.996	1.000
105	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(14), RANGAP1(3)	12212797	18	16	18	3	1	7	2	3	5	0	0.602	0.996	1.000
106	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(3), NFKB1(5), NOX1(4), RELA(3), SOD1(1), XDH(9)	14018124	27	26	27	5	5	7	2	8	5	0	0.253	0.996	1.000
107	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GGT1(4), SHMT1(1), SHMT2(3)	8049711	10	9	10	3	3	3	1	2	1	0	0.632	0.996	1.000
108	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), UGDH(1)	11901798	16	16	15	3	3	2	4	2	5	0	0.376	0.997	1.000
109	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA2(4), CCND1(1), CCNE1(2), CCNE2(3), CDK2(2), CDK4(1), CDKN2A(1), E2F1(5), E2F2(1), E2F4(2), PRB1(3)	11622028	25	23	24	6	5	6	2	3	9	0	0.513	0.997	1.000
110	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(2), CFL1(1), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), LIMK1(7), MAP2K1(5), MAPK1(1), MAPK3(1), NOX1(4), PIK3C2G(8), PLCB1(12), PPP1R12B(4), PRKCA(4), PTK2(7), RAF1(4), ROCK2(9)	36498650	86	67	84	11	13	20	12	18	23	0	0.0327	0.997	1.000
111	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), OXCT1(5)	4921357	7	5	7	3	1	3	0	3	0	0	0.811	0.997	1.000
112	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(3), HLA-A(3), IL18(2), ITGB1(5), KLRC1(5), KLRC3(1), KLRD1(1), LAT(1), MAP2K1(5), MAPK3(1), PAK1(3), PTK2B(6), SYK(4), VAV1(6)	21547223	46	43	45	9	4	11	9	14	8	0	0.215	0.997	1.000
113	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(2), HSD3B7(1), RDH11(3), RDH12(2), RDH13(2), RDH14(2)	6730050	13	13	13	6	1	2	3	4	3	0	0.841	0.998	1.000
114	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(8), PRKCA(4), PTK2B(6)	9594274	19	18	19	8	3	5	3	2	6	0	0.857	0.998	1.000
115	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(3), UBE2A(2), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2J1(3), UBE2J2(2), UBE2L3(1), UBE2L6(2), UBE3A(3)	14868641	25	23	25	5	2	7	7	4	5	0	0.445	0.998	1.000
116	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLUD1(2), GLUD2(3)	6379075	9	8	9	3	2	1	1	2	3	0	0.829	0.998	1.000
117	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	HRAS(2), JUN(3), MAP2K1(5), MAPK1(1), MAPK3(1), MYC(1), NFKB1(5), NFKBIA(3), PLCB1(12), PRKCA(4), RAF1(4), RELA(3)	21357975	44	36	44	8	10	10	4	10	10	0	0.171	0.998	1.000
118	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3E(3), CD3G(3), IFNG(2), IL2RA(2), IL4(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4), TOB1(2)	15483408	31	28	31	7	6	8	4	9	4	0	0.380	0.998	1.000
119	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(3), UGDH(1), UXS1(3)	5794111	8	7	8	3	2	4	1	1	0	0	0.783	0.998	1.000
120	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(11), ARHGDIB(1), BIRC2(3), BIRC3(4), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(2), DFFA(4), DFFB(2), LMNA(4), LMNB1(2), LMNB2(3), PRF1(2)	25603114	52	39	51	9	4	18	10	6	14	0	0.256	0.998	1.000
121	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(2), FOSB(2), GRIA2(3)	5077611	7	7	7	3	3	3	0	0	1	0	0.755	0.998	1.000
122	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(5), ALAS2(7), GATA1(2), HBA2(2), HBB(1), HMBS(3), UROD(2), UROS(2)	11920638	24	20	23	6	5	6	3	6	4	0	0.525	0.999	1.000
123	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(4), CARS2(5), CDO1(3), CTH(3), GOT1(2), GOT2(1), LDHA(2), LDHC(4), SULT1B1(2), SULT1C2(1), SULT1C4(1), SULT4A1(2)	17561185	30	29	30	6	1	13	4	2	10	0	0.387	0.999	1.000
124	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(23), ATR(13), CDC25C(4), CHEK1(2), CHEK2(5)	21986791	47	40	46	8	6	16	4	10	11	0	0.332	0.999	1.000
125	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(3), BRAF(5), CREB1(1), CREB5(5), MAPK1(1), RAF1(4), SNX13(5), SRC(1), TERF2IP(3)	16727496	29	28	29	5	6	8	3	8	4	0	0.221	0.999	1.000
126	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(2), NR1I3(2), PTGS1(5), PTGS2(6)	7605073	17	14	17	5	3	3	3	3	5	0	0.591	0.999	1.000
127	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(1), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ENPP1(7), ENPP3(5), FLAD1(7), MTMR1(1), MTMR2(2), MTMR6(3), RFK(1), TYR(5)	21727513	44	37	43	8	8	12	11	7	6	0	0.162	0.999	1.000
128	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(3), CHAT(2), DBH(6), DDC(3), GAD1(3), GAD2(3), MAOA(2), PAH(3), PNMT(1), SLC18A3(3), TH(2), TPH1(2)	19308078	34	32	34	7	10	6	7	5	6	0	0.228	0.999	1.000
129	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(5), GGPS1(2), IDI1(5), IDI2(1), SQLE(2)	6360825	19	15	18	5	3	9	3	1	3	0	0.647	0.999	1.000
130	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	30	APAF1(11), BID(3), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP9(2), CFLAR(1), CHUK(7), DFFA(4), DFFB(2), GAS2(3), LMNA(4), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), SPTAN1(12), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TNFSF12(3), TRAF2(1)	45529494	87	59	86	10	18	30	14	9	16	0	0.00415	0.999	1.000
131	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(4), HADHA(2)	7034729	7	7	7	3	0	2	2	2	1	0	0.848	0.999	1.000
132	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3), IFNG(2), IL12B(2), IL18(2)	4484252	9	9	9	4	1	1	1	5	1	0	0.878	1.000	1.000
133	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(11), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4)	13312951	30	26	30	9	5	9	5	4	7	0	0.771	1.000	1.000
134	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(4), HADH(2), HADHA(2), HSD17B10(1), HSD17B4(8), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(3), VNN2(7)	17034966	34	32	34	8	5	13	8	5	3	0	0.411	1.000	1.000
135	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(4), SHMT1(1), SHMT2(3)	5978340	9	8	9	4	4	2	1	1	1	0	0.791	1.000	1.000
136	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(3), SRP19(1), SRP54(1), SRP68(3), SRP72(2), SRPR(8)	10935626	19	17	18	5	1	5	1	6	6	0	0.586	1.000	1.000
137	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), JUN(3), KEAP1(3), MAPK1(1), MAPK14(1), MAPK8(2), NFE2L2(3), PRKCA(4)	12291478	18	18	18	9	5	3	2	1	6	1	0.975	1.000	1.000
138	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(11), ARHGAP5(12), ARHGDIB(1), CASP1(3), CASP10(2), CASP3(1), CASP9(2), JUN(3), PRF1(2)	16757104	37	29	37	7	4	9	6	4	14	0	0.421	1.000	1.000
139	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	12	AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(5), RELA(3), SP1(6)	16161439	31	31	31	7	6	11	5	8	1	0	0.308	1.000	1.000
140	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	21	ATM(23), BMPR1B(6), CCND2(2), CDK4(1), DAZL(1), DMC1(2), EGR1(3), ESR2(4), FSHR(9), GJA4(1), INHA(5), LHCGR(10), MLH1(7), MSH5(6), NR5A1(1), NRIP1(10), PGR(6), PRLR(4), SMPD1(2), ZP2(4)	39792470	107	77	105	19	17	25	17	21	27	0	0.0896	1.000	1.000
141	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(1), RDH5(1)	5561748	6	5	6	9	0	1	2	0	3	0	1.000	1.000	1.000
142	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(5), FH(3), IDH1(5), MDH1(1), SDHB(2), SUCLA2(1)	12996217	21	19	21	5	4	5	3	6	3	0	0.375	1.000	1.000
143	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(8), CAPN1(8), CDK5(2), CDK5R1(1), CSNK1A1(3), GSK3B(2), MAPT(3), PPP2CA(3)	13279794	30	26	30	7	5	11	2	6	6	0	0.420	1.000	1.000
144	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	19	CCNB1(3), CCND1(1), CCND2(2), CCND3(4), CCNE1(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN2A(1), E2F1(5), RBL1(6), TFDP1(3)	19063744	39	37	38	9	6	7	8	5	12	1	0.539	1.000	1.000
145	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(8), G6PD(4), GCLC(3), GCLM(2), GGT1(4), GPX2(1), GPX5(1), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), PGD(3)	25970834	47	36	46	8	6	10	11	13	7	0	0.0810	1.000	1.000
146	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(6), CDKN2A(1), E2F1(5), MDM2(3), MYC(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), TBX2(1), TWIST1(2)	18361853	39	37	39	9	7	9	4	7	12	0	0.433	1.000	1.000
147	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(7), MAPK14(1), MAPK8(2), NFKB1(5), RELA(3), TNFRSF13B(2), TNFSF13(3), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4)	20742976	35	32	35	7	7	8	6	7	6	1	0.329	1.000	1.000
148	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(1), CAMK1G(5), HDAC9(4), MEF2A(6), MEF2C(4), MEF2D(3)	11839070	23	20	23	6	1	5	4	9	4	0	0.482	1.000	1.000
149	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(2), PLCB1(12), PLCG1(8), PRKCA(4), VAV1(6)	13145284	32	28	32	8	8	4	4	7	9	0	0.515	1.000	1.000
150	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(5), ALAS2(7), HMBS(3), PPOX(5), UROD(2), UROS(2)	11225032	24	20	23	7	4	6	3	6	5	0	0.678	1.000	1.000
151	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(5), FADS2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1)	14934409	34	29	34	9	2	11	9	9	3	0	0.442	1.000	1.000
152	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	8231840	20	19	20	7	7	3	0	5	5	0	0.761	1.000	1.000
153	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	8231840	20	19	20	7	7	3	0	5	5	0	0.761	1.000	1.000
154	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(5), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), PC(10), PCK1(5), SDHB(2), SUCLA2(1), SUCLG2(1)	29761523	48	38	48	9	9	14	9	11	5	0	0.0705	1.000	1.000
155	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(4), CD3E(3), CD3G(3), CD4(4), CXCR3(6), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), JAK2(7), STAT4(8), TYK2(7)	21419945	58	47	56	13	7	12	11	14	14	0	0.364	1.000	1.000
156	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	10	AKT1(2), CAT(2), GHR(5), HRAS(2), IGF1R(7), SHC1(2), SOD1(1)	13123123	21	17	21	5	4	9	2	3	3	0	0.372	1.000	1.000
157	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), GPI(3), HK1(3), PFKL(1), PGK1(7), PKLR(5), TPI1(2)	12811794	24	23	24	9	2	7	4	5	6	0	0.704	1.000	1.000
158	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(1), PON1(4), PON2(1), PON3(4), RDH11(3), RDH12(2), RDH13(2), RDH14(2)	12751231	26	21	26	8	0	5	5	11	5	0	0.598	1.000	1.000
159	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(2), IL22RA1(4), IL22RA2(3), JAK1(11), JAK2(7), JAK3(8), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), TYK2(7)	26043951	63	54	61	12	13	11	13	10	16	0	0.118	1.000	1.000
160	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(6), AASDHPPT(4), AASS(5)	10170315	15	13	15	5	2	5	3	2	3	0	0.827	1.000	1.000
161	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(2), CREB1(1), HRAS(2), MAPK1(1), MAPK3(1), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NTRK1(8), PLCG1(8), RPS6KA1(6), SHC1(2)	22250511	48	40	47	10	12	10	3	14	9	0	0.168	1.000	1.000
162	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(1), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN1(4), RPN2(2), UBE2A(2), UBE3A(3)	19234805	32	29	32	7	4	11	2	8	6	1	0.403	1.000	1.000
163	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), PER1(9)	11829710	23	19	23	7	2	8	4	5	4	0	0.763	1.000	1.000
164	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(2), AKT1(2), ANXA1(5), CALM2(1), GNAS(11), GNB1(2), NFKB1(5), NOS3(3), NPPA(1), NR3C1(3), RELA(3), SYT1(1)	19355603	39	35	39	8	11	10	4	7	7	0	0.349	1.000	1.000
165	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(4), ACO2(5), ACSS1(1), ACSS2(2), FH(3), IDH1(5), MDH1(1), SUCLA2(1)	19225401	31	26	31	8	4	6	9	7	5	0	0.393	1.000	1.000
166	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1)	11274200	20	19	19	9	3	2	6	2	7	0	0.908	1.000	1.000
167	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1)	11274200	20	19	19	9	3	2	6	2	7	0	0.908	1.000	1.000
168	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(6), ATM(23), BRCA1(13), CDKN1A(1), CHEK1(2), CHEK2(5), JUN(3), MAPK8(2), MDM2(3), MRE11A(7), NFKB1(5), NFKBIA(3), RAD50(6), RAD51(2), RBBP8(5), RELA(3), TP73(2)	40587513	91	78	90	14	13	33	8	14	23	0	0.129	1.000	1.000
169	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADS(2), ACADVL(4), ACSL1(3), ACSL3(3), ACSL4(5), CPT1A(6), CPT2(5), EHHADH(4), HADHA(2), SCP2(1), SLC25A20(4)	24026726	40	31	40	8	6	9	9	9	7	0	0.190	1.000	1.000
170	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(4), AASS(5)	6940483	9	8	9	5	2	3	2	1	1	0	0.938	1.000	1.000
171	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST8SIA1(1)	13871665	22	20	22	6	3	9	3	4	3	0	0.528	1.000	1.000
172	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1)	19232177	29	27	28	7	5	5	11	3	5	0	0.403	1.000	1.000
173	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(2), LPO(4), MPO(5), TPO(7)	11996711	22	20	22	6	6	6	1	4	5	0	0.468	1.000	1.000
174	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(2), CFTR(14), GNAS(11), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), SLC9A3R1(3)	17778779	47	35	47	10	12	12	7	7	9	0	0.278	1.000	1.000
175	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(1), HMGCS1(6), HMGCS2(3), OXCT1(5), OXCT2(5)	10449597	22	16	20	7	5	7	1	7	2	0	0.679	1.000	1.000
176	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(4), CHPT1(4), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), PCYT1A(2), PCYT1B(6), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2)	19619853	54	45	54	12	5	20	13	8	7	1	0.289	1.000	1.000
177	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), HRAS(2), PTK2B(6), SHC1(2), SOS1(5), SRC(1)	12359387	17	17	17	6	3	4	3	3	4	0	0.762	1.000	1.000
178	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(4), NR0B2(2), NR1H3(2), NR1H4(4), RXRA(2)	7282015	15	15	15	8	4	4	2	4	1	0	0.926	1.000	1.000
179	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(7), CREBBP(15), EP300(13), HDAC3(1), IKBKB(5), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4)	31306496	67	52	66	12	16	16	11	10	14	0	0.105	1.000	1.000
180	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), ADSS(3), IMPDH1(2), POLB(1), POLD1(5), POLG(7), PRPS2(1), RRM1(4), SRM(4)	17662458	30	27	29	8	7	7	7	1	7	1	0.589	1.000	1.000
181	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CCL2(1), CSF1(5), IL6(1), LDLR(4), LPL(1)	7495964	14	14	14	7	2	5	4	2	1	0	0.897	1.000	1.000
182	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(1), PSMB10(1), PSMB4(1), PSMB5(2), PSMB6(2)	11752676	18	18	18	6	2	8	0	5	3	0	0.693	1.000	1.000
183	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(2), MTMR6(3), NFS1(1), THTPA(3), TPK1(2)	9215377	12	11	12	5	2	7	1	1	1	0	0.907	1.000	1.000
184	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(7), DUSP1(1), IKBKAP(12), IKBKB(5), LTA(2), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFAIP3(3), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3)	28262776	57	43	57	12	11	18	12	6	9	1	0.161	1.000	1.000
185	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(3), ATG7(5), GABARAP(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNG(2), PIK3C3(6), PIK3R4(10), PRKAA1(3), PRKAA2(2), ULK1(4), ULK2(5), ULK3(4)	30239276	77	59	77	16	5	31	16	18	7	0	0.202	1.000	1.000
186	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(2), CHST11(1), PAPSS1(2), PAPSS2(2), SULT1A1(1), SULT1A2(2), SULT1E1(3), SULT2B1(2), SUOX(4)	12350348	19	17	19	9	5	4	4	3	3	0	0.939	1.000	1.000
187	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(1), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD1(9), PSMD11(3), PSMD12(3), PSMD2(2), PSMD6(3)	23401693	40	35	40	9	6	19	2	6	7	0	0.372	1.000	1.000
188	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(3), ACOX3(5), ELOVL5(5), ELOVL6(4), FADS1(3), FADS2(7), FASN(14), HADHA(2), SCD(1)	19501846	45	38	45	12	4	16	10	7	8	0	0.284	1.000	1.000
189	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(13), NRG2(4), NRG3(6), PRKCA(4), PSEN1(2)	13148729	29	26	29	9	0	12	6	7	4	0	0.774	1.000	1.000
190	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(2), CD86(4), HLA-DRB1(10), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), IL2RA(2), IL4(1), IL4R(6)	17624026	48	41	48	13	3	12	13	15	5	0	0.544	1.000	1.000
191	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(1), ALPP(3), ALPPL2(2), FPGS(4), GCH1(1)	8308147	11	10	11	5	4	1	3	2	1	0	0.770	1.000	1.000
192	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(7), DUSP1(1), IKBKAP(12), IKBKB(5), NFKB1(5), NFKBIA(3), RELA(3), TNFAIP3(3), TRAF3(3), TRAF6(4)	22657068	46	37	46	10	8	15	7	7	8	1	0.275	1.000	1.000
193	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2)	21680435	45	40	45	11	5	17	8	8	7	0	0.380	1.000	1.000
194	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), AKT2(4), AKT3(5), BPNT1(2), ILK(3), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(6), PTK2B(6), SHC1(2), SOS1(5)	24108634	39	36	39	9	6	11	6	7	9	0	0.361	1.000	1.000
195	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(3), GFPT1(3), GNE(5), GNPDA2(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), PGM3(2), UAP1(3)	24458265	40	35	40	9	7	13	5	11	4	0	0.258	1.000	1.000
196	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), HADH(2), HADHA(2), HADHB(3), HSD17B10(1), HSD17B4(8), PPT1(1), PPT2(3)	11920143	22	19	22	7	4	10	5	2	1	0	0.628	1.000	1.000
197	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(4), PRKCA(4), PTPRA(6), SRC(1)	13174999	22	21	22	7	4	9	1	4	4	0	0.706	1.000	1.000
198	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), GLB1(4), HEXA(3), HEXB(3), LCT(17), ST3GAL1(2), ST3GAL2(2), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(1), ST8SIA1(1)	22874817	44	40	44	11	7	13	9	10	5	0	0.356	1.000	1.000
199	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(2), EPO(1), FLT3(4), IL11(1), IL1A(1), IL3(1), IL6(1), KITLG(3), TGFB1(2), TGFB2(1), TGFB3(1)	12176022	18	18	18	6	5	2	5	4	2	0	0.707	1.000	1.000
200	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(5), FURIN(3), NOTCH1(8), PSEN1(2)	11146319	18	17	18	6	4	1	8	2	3	0	0.720	1.000	1.000
201	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(3), EPX(4), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TAT(3), TPO(7)	30156919	69	51	68	16	13	14	12	15	15	0	0.228	1.000	1.000
202	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	23	ARHGDIB(1), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CFLAR(1), DAXX(2), DFFA(4), DFFB(2), FAF1(7), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(24), PTPN13(16), RIPK2(2), SPTAN1(12)	52311661	100	70	99	15	14	28	15	18	25	0	0.0567	1.000	1.000
203	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), NAT1(2), XDH(9)	11681368	23	20	23	9	4	4	5	7	3	0	0.815	1.000	1.000
204	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(5), CTSD(1), ESR1(5), GREB1(6), MTA3(2), PDZK1(1), TUBA8(1)	14259200	21	20	21	8	4	9	2	2	4	0	0.667	1.000	1.000
205	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(2), ARSB(3), ARSE(4), ASAH1(1), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(2), SPTLC1(4), SPTLC2(6), UGCG(1)	32171469	63	51	61	14	13	16	11	17	6	0	0.164	1.000	1.000
206	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(6), CRK(1), CXCR4(3), GNAI1(2), GNAQ(1), GNB1(2), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), NFKB1(5), PIK3C2G(8), PLCG1(8), PRKCA(4), PTK2(7), PTK2B(6), RAF1(4), RELA(3)	34444165	69	56	68	13	13	20	8	16	11	1	0.107	1.000	1.000
207	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(2), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), ST3GAL1(2), ST3GAL2(2), ST8SIA1(1)	14722301	23	21	23	7	4	10	2	4	3	0	0.607	1.000	1.000
208	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(2), F2R(4), F5(25), F7(2), FGA(7), FGB(1), FGG(7), PROC(3), PROS1(4), SERPINC1(6), TFPI(3)	23272902	69	55	69	16	9	20	17	14	9	0	0.339	1.000	1.000
209	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(5), ANXA3(3), ANXA4(3), ANXA5(1), ANXA6(5), CYP11A1(1), EDN1(5), EDNRA(3), EDNRB(2), HPGD(1), HSD11B1(3), HSD11B2(2), PLA2G4A(7), PTGDR(2), PTGDS(2), PTGER4(1), PTGFR(1), PTGIS(4), PTGS1(5), PTGS2(6), S100A6(1), TBXAS1(3)	28369478	66	49	66	14	12	19	9	15	11	0	0.160	1.000	1.000
210	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(2), FH(3), MDH1(1), OGDH(7), SUCLA2(1)	13846649	19	17	19	7	2	7	4	3	3	0	0.725	1.000	1.000
211	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CASP9(2), CHUK(7), GHR(5), NFKB1(5), NFKBIA(3), PDPK1(2), PPP2CA(3), RELA(3)	14691220	33	25	33	9	8	13	5	3	4	0	0.585	1.000	1.000
212	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(4), AKT3(5), CDKN1A(1), ELK1(4), HRAS(2), MAP2K1(5), MAP2K2(2), NGFR(1), NTRK1(8), PIK3CD(6), SHC1(2), SOS1(5)	19096734	47	42	47	12	9	12	7	10	9	0	0.318	1.000	1.000
213	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	12	AKT1(2), BCAR1(6), ILK(3), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(1), PDPK1(2), PTK2(7), SHC1(2), SOS1(5)	19879900	35	31	35	9	6	8	5	9	6	1	0.537	1.000	1.000
214	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	62	APAF1(11), BAD(1), BAK1(3), BAX(3), BCL2L1(1), BCL2L11(4), BID(3), BIRC2(3), BIRC3(4), BIRC5(1), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(2), CHUK(7), DFFA(4), DFFB(2), FAS(1), FASLG(2), HELLS(3), IKBKB(5), IRF1(2), IRF2(1), IRF3(6), IRF4(2), IRF5(2), IRF6(3), JUN(3), LTA(2), MAPK10(4), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PLEKHG5(2), PRF1(2), RELA(3), RIPK1(5), TNFRSF10B(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TP73(2), TRAF1(2), TRAF2(1), TRAF3(3)	71230556	145	94	143	22	25	48	24	18	28	2	0.00411	1.000	1.000
215	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(2), ACAT1(2), EHHADH(4), HADHA(2), HADHB(3)	12171347	14	14	14	6	2	3	4	4	1	0	0.824	1.000	1.000
216	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	21	ABL1(6), ATM(23), ATR(13), CCND1(1), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN2A(1), E2F1(5), GSK3B(2), HDAC1(6), SKP2(2), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1)	37998830	75	61	73	15	12	15	11	16	21	0	0.283	1.000	1.000
217	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(11), JAK2(7), JAK3(8), PIAS1(3), PIAS3(2), PTPRU(10), REG1A(1), SOAT1(2)	19655267	46	39	46	11	9	8	11	6	11	1	0.418	1.000	1.000
218	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(5), CAP1(2), CCNB1(3), CDC25C(4), GNAI1(2), GNAS(11), GNB1(2), HRAS(2), MAPK1(1), MAPK3(1), MYT1(10), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RPS6KA1(6), SRC(1)	28263217	65	55	64	15	16	18	10	9	11	1	0.285	1.000	1.000
219	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(2), BAD(1), HRAS(2), IGF1R(7), IRS1(4), MAP2K1(5), MAPK1(1), MAPK3(1), RAF1(4), SHC1(2), SOS1(5)	20653100	34	30	34	9	4	13	3	8	6	0	0.529	1.000	1.000
220	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	37	APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(3), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP9(2), FAS(1), FASLG(2), JUN(3), MAPK10(4), MCL1(1), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), PARP1(6), PRF1(2), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1)	44181530	86	59	85	16	16	32	15	8	15	0	0.0677	1.000	1.000
221	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP14(4), MMP2(3), MMP9(3), RECK(2), TIMP1(1), TIMP3(3)	10808870	18	16	18	9	4	6	2	5	1	0	0.902	1.000	1.000
222	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(3), CASP3(1), CASP6(2), CASP7(2), CASP9(2), EIF2S1(3), PRKCA(4), PTK2(7), STAT1(4), TLN1(15)	38449830	84	65	83	17	11	33	10	11	19	0	0.215	1.000	1.000
223	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(4), GNAI1(2), GNB1(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(12), PRKCA(4), PTGS1(5), PTK2(7), RAF1(4), SRC(1), SYK(4), TBXAS1(3)	34849949	77	55	77	15	14	19	18	18	8	0	0.102	1.000	1.000
224	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	23	ARHGDIB(1), BAG4(1), CASP2(3), CASP3(1), DFFA(4), DFFB(2), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MADD(15), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(24), RIPK1(5), SPTAN1(12), TNFRSF1A(4), TRAF2(1)	46732582	95	70	93	17	17	26	16	14	22	0	0.0860	1.000	1.000
225	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(7), ALDH4A1(3), ALDH5A1(2), CAD(15), CPS1(12), EPRS(11), GAD1(3), GAD2(3), GCLC(3), GCLM(2), GFPT1(3), GLS(4), GLUD1(2), GLUL(3), GMPS(5), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSS(3), NADSYN1(2), PPAT(5), QARS(10)	47706901	106	73	106	21	9	36	23	21	17	0	0.0800	1.000	1.000
226	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(7), ALOX15(4), ALOX5(3), CBR1(3), CYP4F2(3), CYP4F3(2), EPX(4), GGT1(4), LPO(4), LTA4H(2), MPO(5), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PRDX1(3), PRDX2(1), PRDX5(4), PTGDS(2), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(6), TBXAS1(3), TPO(7)	39640699	92	67	92	18	17	22	18	19	16	0	0.0357	1.000	1.000
227	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(2), BAD(1), CHRNB1(1), CHRNG(2), MUSK(8), PTK2(7), PTK2B(6), SRC(1), TERT(2)	17878039	30	24	30	9	6	7	5	6	6	0	0.516	1.000	1.000
228	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(4), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), JAK1(11), JAK3(8), JUN(3), LCK(2), MAP2K1(5), MAPK3(1), MAPK8(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4)	33103412	74	60	74	16	15	16	13	15	15	0	0.146	1.000	1.000
229	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKM(8), PFKP(6), PGD(3), PGLS(3), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TAL1(1), TALDO1(2), TKT(3)	27882672	57	44	55	14	10	12	8	13	14	0	0.281	1.000	1.000
230	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(8), G6PD(4), GCLC(3), GCLM(2), GGT1(4), GPX2(1), GPX5(1), GSR(2), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), TXNDC12(1)	28949663	50	38	49	10	5	10	12	13	10	0	0.152	1.000	1.000
231	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(15), EP300(13), IL2RG(2), IL7(1), IL7R(4), JAK1(11), JAK3(8), LCK(2), NMI(2), PTK2B(6), STAT5A(6), STAT5B(5)	34706634	75	58	75	16	13	16	15	14	17	0	0.191	1.000	1.000
232	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNG(2), IL12B(2), IL15(3), IL16(2), IL18(2), IL1A(1), IL3(1), IL4(1), IL6(1), LTA(2)	13790104	18	15	18	8	2	5	3	7	1	0	0.875	1.000	1.000
233	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(3), CCR2(4), CCR3(2), CCR4(1), CCR5(1), CCR7(4), CD28(2), CD4(4), CXCR3(6), CXCR4(3), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18R1(4), IL4(1), IL4R(6), TGFB1(2), TGFB2(1), TGFB3(1)	29283586	62	44	62	17	6	13	13	21	9	0	0.463	1.000	1.000
234	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(4), HRAS(2), IL3(1), IL3RA(3), JAK2(7), MAP2K1(5), MAPK3(1), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5)	25105744	45	42	45	10	10	11	6	7	11	0	0.212	1.000	1.000
235	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(5), ERBB3(17), NRG1(2), UBE2D1(1)	14760606	30	26	28	9	4	7	10	7	2	0	0.660	1.000	1.000
236	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), AGMAT(4), ALDH18A1(4), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CPS1(12), GATM(3), MAOA(2), MAOB(4), NAGS(1), OTC(3), SAT1(3), SAT2(2), SRM(4)	41650067	80	60	79	17	7	14	26	18	15	0	0.133	1.000	1.000
237	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(1), IL6R(4), JAK1(11), JAK2(7), JAK3(8), PIAS3(2), PTPRU(10), REG1A(1), SRC(1), STAT3(5)	21589592	52	42	52	13	9	6	13	10	13	1	0.453	1.000	1.000
238	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(1), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHRS2(4), DHRS3(1), DHRS7(1), PON1(4), PON2(1), PON3(4)	25328886	49	36	48	12	7	13	8	17	4	0	0.278	1.000	1.000
239	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(8), ABAT(7), ADSL(3), ADSS(3), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), CAD(15), CRAT(6), DARS(3), DDO(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), PC(10)	36950181	85	66	85	20	12	23	23	12	15	0	0.142	1.000	1.000
240	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	18	AKT1(2), BCR(3), CRKL(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), MYC(1), RAF1(4), SOS1(5), STAT1(4), STAT5A(6), STAT5B(5)	28442696	51	48	51	11	11	13	5	12	10	0	0.234	1.000	1.000
241	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(3), CA1(2), CA12(1), CA14(4), CA2(2), CA4(1), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(4), GLUD1(2), GLUL(3), HAL(7)	27221326	54	46	54	13	5	12	17	11	9	0	0.373	1.000	1.000
242	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(1), CTH(3), GGT1(4), MARS(9), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(2), PAPSS2(2), SCLY(3), SEPHS1(2)	17381876	34	28	33	10	7	7	9	5	6	0	0.448	1.000	1.000
243	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(5), ALDOB(3), ALDOC(2), DERA(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKL(1), PFKM(8), PFKP(6), PGD(3), PGLS(3), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TALDO1(2), TKT(3), TKTL1(3), TKTL2(3)	33780432	65	50	63	16	10	13	10	14	18	0	0.289	1.000	1.000
244	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(11), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP7(2), CASP9(2), DFFA(4), DFFB(2), PRF1(2), SCAP(1), SREBF1(3), SREBF2(5)	23262039	42	31	41	11	2	18	9	2	11	0	0.523	1.000	1.000
245	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(23), ATR(13), BRCA1(13), CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(4), CDC34(1), CDKN1A(1), CHEK1(2), CHEK2(5), EP300(13), MDM2(3), MYT1(10), PRKDC(24), RPS6KA1(6), WEE1(4)	61381872	129	102	127	24	17	36	18	24	34	0	0.200	1.000	1.000
246	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(15), EP300(13), ESR1(5), MAPK1(1), MAPK3(1), PELP1(6), SRC(1)	21335176	42	36	42	11	8	9	8	9	8	0	0.541	1.000	1.000
247	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), DBH(6), DCT(4), DDC(3), FAH(2), GOT1(2), GOT2(1), GSTZ1(1), HGD(4), HPD(4), MAOA(2), MAOB(4), PNMT(1), TAT(3), TH(2), TPO(7), TYR(5)	43688686	89	67	88	21	20	16	23	15	15	0	0.190	1.000	1.000
248	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(5), CS(2), GRHPR(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5)	18570702	35	31	35	10	6	14	5	3	7	0	0.362	1.000	1.000
249	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(10), GABBR1(4), GPRC5A(1), GPRC5B(1), GPRC5C(2), GPRC5D(1), GRM1(9), GRM2(3), GRM3(9), GRM4(3), GRM5(4), GRM7(2), GRM8(5)	27432770	54	46	54	15	14	14	11	7	8	0	0.193	1.000	1.000
250	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	CNR1(1), CNR2(1), DNMT1(8), PTAFR(1), PTGDR(2), PTGER4(1), PTGFR(1)	13631361	15	14	15	9	5	3	4	2	1	0	0.875	1.000	1.000
251	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(11), BAD(1), BAX(3), BCL2A1(1), BCL2L1(1), BCL2L2(1), BOK(1), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(2), CD40(2), CD40LG(1), DAXX(2), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKE(6), LTA(2), MCL1(1), NFKB1(5), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(8), PTPN13(16), RIPK1(5), TFG(2), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3), TRAF6(4)	59823690	117	76	115	23	15	39	18	18	26	1	0.0908	1.000	1.000
252	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2)	23535328	16	14	16	8	1	5	1	6	2	1	0.965	1.000	1.000
253	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	48	ACTG1(8), APAF1(11), ARHGDIB(1), BAG4(1), BID(3), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP9(2), CFLAR(1), CHUK(7), DAXX(2), DFFA(4), DFFB(2), GSN(2), LMNA(4), LMNB1(2), LMNB2(3), MAP2K7(1), MAP3K5(12), MAPK8(2), MDM2(3), NFKB1(5), NFKBIA(3), NUMA1(6), PAK2(2), PRKCD(5), PRKDC(24), PSEN1(2), PSEN2(4), PTK2(7), RASA1(2), RELA(3), RIPK1(5), SPTAN1(12), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1)	90863960	175	119	172	27	36	48	29	27	35	0	0.00418	1.000	1.000
254	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(3), CA1(2), CA12(1), CA13(1), CA14(4), CA2(2), CA4(1), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(4), GLUD1(2), GLUD2(3), GLUL(3), HAL(7)	30342988	58	50	58	14	7	13	17	12	9	0	0.355	1.000	1.000
255	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(2), DLAT(2), DLD(1), DLST(3), FH(3), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), PC(10), PDHA1(3), PDHA2(4), PDHB(1), PDHX(3), PDK1(2), PDK2(1), PDK4(4), PDP2(2), SDHB(2), SUCLA2(1), SUCLG2(1)	41013126	63	50	63	14	13	15	13	15	7	0	0.129	1.000	1.000
256	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(7), IKBKB(5), IL1A(1), IL1R1(1), IRAK1(3), MAP3K7(3), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TLR4(15), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4)	29743672	65	49	63	16	11	20	11	11	12	0	0.330	1.000	1.000
257	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(7), CREBBP(15), DUSP1(1), EP300(13), IKBKB(5), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(1), MYD88(1), NFKB1(5), NFKBIA(3), NR3C1(3), RELA(3), TGFBR1(4), TGFBR2(4), TLR2(3)	42170808	75	57	75	16	16	18	12	13	16	0	0.204	1.000	1.000
258	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL2RG(2), IL4(1), IL4R(6), IRS1(4), JAK1(11), JAK3(8), RPS6KB1(4), SHC1(2), STAT6(7)	19984208	47	38	47	13	5	12	10	8	12	0	0.522	1.000	1.000
259	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), EPRS(11), GAMT(1), GATM(3), GLUD1(2), GLUD2(3), GOT1(2), GOT2(1), LAP3(2), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(4), P4HA3(3), PARS2(2), PRODH(2), PYCR2(2), PYCRL(1), RARS(5), RARS2(3)	50728566	106	77	105	22	20	29	32	13	12	0	0.0580	1.000	1.000
260	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(4), HRAS(2), IL6(1), IL6R(4), IL6ST(9), JAK1(11), JAK2(7), JAK3(8), JUN(3), MAP2K1(5), MAPK3(1), PTPN11(1), RAF1(4), SHC1(2), SOS1(5), SRF(1), STAT3(5)	33543120	76	59	76	18	12	14	16	17	17	0	0.344	1.000	1.000
261	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(8), AARS2(5), ABAT(7), ACY3(3), ADSL(3), ADSS(3), ADSSL1(1), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), ASS1(1), CAD(15), CRAT(6), DARS(3), DARS2(2), DDO(1), DLAT(2), DLD(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), NARS2(2), PC(10), PDHA1(3), PDHA2(4), PDHB(1)	53692519	110	85	110	24	19	27	29	15	20	0	0.0927	1.000	1.000
262	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(2), GLB1(4), GNS(2), GUSB(6), HEXA(3), HEXB(3), IDS(2), IDUA(1), LCT(17), NAGLU(1)	20198583	44	40	44	13	8	12	7	11	6	0	0.592	1.000	1.000
263	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), ADRB2(2), GNAS(11), PLCE1(15), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RAP2B(2)	20212950	47	41	47	12	11	9	9	7	11	0	0.524	1.000	1.000
264	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(5), ALDOB(3), ALDOC(2), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GAPDHS(2), GCK(3), GOT1(2), GOT2(1), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(2), LDHC(4), MDH1(1), PC(10), PCK1(5), PDHA1(3), PDHA2(4), PDHB(1), PDHX(3), PFKL(1), PFKM(8), PFKP(6), PGAM2(1), PGK1(7), PGK2(1), PKLR(5), TNFAIP1(1), TPI1(2)	60145134	110	82	108	25	16	29	20	23	22	0	0.0761	1.000	1.000
265	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(5), PGAP1(10), PIGA(5), PIGB(2), PIGG(6), PIGL(1), PIGM(3), PIGN(4), PIGO(3), PIGQ(3), PIGS(2), PIGT(4), PIGV(2), PIGW(3), PIGZ(3)	35481889	56	44	56	15	6	19	14	12	5	0	0.302	1.000	1.000
266	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(2), GLB1(4), GNS(2), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(2), IDUA(1), LCT(17), NAGLU(1), SPAM1(4)	28977154	68	60	69	19	12	20	10	15	11	0	0.485	1.000	1.000
267	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	AKT1(2), AKT2(4), AKT3(5), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GSK3A(5), GSK3B(2), IARS(8), INPP5D(4), PDK1(2), PPP1R13B(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SOS1(5), SOS2(6), TEC(6), YWHAB(2), YWHAG(1), YWHAZ(3)	46861937	96	72	95	21	18	28	12	15	23	0	0.153	1.000	1.000
268	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP1(1), INPP4A(5), INPP4B(7), INPP5A(1), INPPL1(6), ITPKA(1), ITPKB(8), OCRL(8), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CB(8), PIK3CG(5), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCG1(8), PLCG2(8)	61014499	130	94	129	27	21	38	17	21	32	1	0.104	1.000	1.000
269	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(5), AFMID(1), CS(2), GRHPR(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5)	19498658	36	32	36	11	6	14	5	4	7	0	0.439	1.000	1.000
270	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(3), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MPL(2), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), THPO(3)	37533202	71	60	71	16	14	17	8	15	17	0	0.315	1.000	1.000
271	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(4), CBS(1), CTH(3), GGT1(4), HEMK1(2), LCMT1(1), LCMT2(10), MARS(9), MARS2(1), MAT1A(2), MAT2B(2), METTL2B(4), PAPSS1(2), PAPSS2(2), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(3), SEPHS1(2), SEPHS2(3), WBSCR22(2)	34711513	79	60	78	21	13	24	20	9	12	1	0.305	1.000	1.000
272	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G2(2), EIF4G3(5), GHR(5), IRS1(4), MAPK1(1), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(2), PDK2(1), PDPK1(2), PRKCA(4), RPS6KB1(4)	32976753	57	44	56	13	9	25	4	8	11	0	0.472	1.000	1.000
273	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(2), CALCRL(3), CD97(9), CRHR1(3), CRHR2(1), ELTD1(10), EMR1(5), EMR2(8), GHRHR(4), GIPR(1), GLP1R(2), GLP2R(3), GPR64(9), LPHN1(4), LPHN2(11), LPHN3(6), VIPR1(1), VIPR2(3)	39743269	89	69	89	26	9	26	15	17	21	1	0.428	1.000	1.000
274	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(7), ALDH4A1(3), ALDH5A1(2), CAD(15), CPS1(12), EARS2(3), EPRS(11), GAD1(3), GAD2(3), GCLC(3), GCLM(2), GFPT1(3), GFPT2(9), GLS(4), GLUD1(2), GLUD2(3), GLUL(3), GMPS(5), GNPNAT1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSR(2), GSS(3), NADSYN1(2), NAGK(1), PPAT(5), QARS(10)	56873689	126	85	125	28	13	39	25	26	23	0	0.143	1.000	1.000
275	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(4), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), OTC(3)	24789867	48	40	48	13	4	11	18	9	6	0	0.423	1.000	1.000
276	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME3(4), PGK1(7), PGK2(1), PKLR(5), TKT(3), TKTL1(3), TKTL2(3), TPI1(2)	28508625	49	43	49	14	9	16	9	7	8	0	0.356	1.000	1.000
277	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(4), EPO(1), EPOR(4), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PLCG1(8), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5)	30787241	62	54	62	16	15	17	5	10	15	0	0.388	1.000	1.000
278	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(4), BCR(3), BLNK(1), ELK1(4), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAPK1(1), MAPK3(1), MAPK8IP3(8), PAPPA(13), RPS6KA1(6), RPS6KA3(8), SHC1(2), SOS1(5), SYK(4), VAV1(6), VAV2(3), VAV3(7)	40592210	92	68	91	23	20	21	16	19	16	0	0.270	1.000	1.000
279	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(3), BAD(1), BRAF(5), CREB1(1), CREB5(5), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(6), MAP2K1(5), MAP2K2(2), MAP3K8(4), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), SHC1(2), SOS1(5), SOS2(6), TRAF3(3)	42269801	89	68	88	21	16	22	8	20	22	1	0.271	1.000	1.000
280	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(9), ACO1(4), ACO2(5), CLYBL(3), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), OGDHL(6), PC(10), PCK1(5), PCK2(4), SDHB(2), SUCLA2(1), SUCLG2(1)	43207811	77	62	77	20	15	16	20	17	9	0	0.232	1.000	1.000
281	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), GCK(3), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(4), MPI(2), PFKFB3(4), PFKFB4(3), PFKM(8), PFKP(6), PMM1(2), SORD(2), TPI1(2)	34537095	67	53	65	19	12	13	10	18	14	0	0.445	1.000	1.000
282	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	188	ACTB(5), ACTG1(8), ACTN1(5), ACTN2(10), ACTN4(7), AKT1(2), AKT2(4), AKT3(5), ARHGAP5(12), BAD(1), BCAR1(6), BIRC2(3), BIRC3(4), BRAF(5), CAPN2(8), CAV1(4), CCND1(1), CCND2(2), CCND3(4), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(10), COL4A2(10), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(12), COL6A1(3), COL6A2(3), COL6A3(15), COL6A6(14), COMP(5), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(5), DOCK1(8), EGF(5), EGFR(5), ELK1(4), FARP2(9), FIGF(3), FLNA(17), FLNB(15), FLNC(21), FLT1(5), FN1(9), GSK3B(2), HGF(5), HRAS(2), IBSP(5), IGF1R(7), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(2), ITGB6(6), ITGB7(5), ITGB8(4), JUN(3), KDR(8), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(3), MAP2K1(5), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MET(10), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PARVA(3), PARVG(3), PDGFB(2), PDGFRA(6), PDGFRB(7), PDPK1(2), PGF(5), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP5K1C(5), PPP1CB(1), PPP1R12A(7), PRKCA(4), PRKCG(3), PTK2(7), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF1(5), RELN(26), RHOA(6), ROCK1(8), ROCK2(9), SHC1(2), SHC2(2), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SPP1(2), SRC(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TLN1(15), TLN2(14), TNC(8), TNN(10), TNR(10), TNXB(16), VAV1(6), VAV2(3), VAV3(7), VCL(6), VEGFA(1), VEGFC(2), VTN(3), VWF(11), ZYX(1)	511795021	999	430	987	310	190	238	177	183	206	5	0.899	1.000	1.000
283	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY7(11), ADCY8(6), ADCY9(14), ADORA2A(3), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), AGTR1(4), ATP2A1(11), ATP2A2(3), ATP2A3(1), ATP2B1(14), ATP2B2(9), ATP2B3(9), ATP2B4(10), AVPR1B(5), BDKRB1(4), BDKRB2(4), BST1(2), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(17), CACNA1E(28), CACNA1F(16), CACNA1G(10), CACNA1H(10), CACNA1I(6), CACNA1S(8), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), CCKAR(3), CCKBR(2), CD38(3), CHRM1(4), CHRM2(6), CHRM3(3), CHRNA7(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), EDNRA(3), EDNRB(2), EGFR(5), ERBB3(17), ERBB4(13), F2R(4), GNA11(3), GNA14(1), GNAQ(1), GNAS(11), GRIN1(3), GRIN2A(16), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), GRPR(3), HRH1(4), HRH2(4), HTR2A(5), HTR2C(5), HTR5A(4), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), LHCGR(10), MYLK(11), MYLK2(5), NOS1(13), NOS3(3), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), PDE1A(5), PDE1B(5), PDE1C(5), PDGFRA(6), PDGFRB(7), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(10), PLN(1), PPID(3), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTAFR(1), PTGER3(2), PTGFR(1), PTK2B(6), RYR1(30), RYR2(53), RYR3(43), SLC25A4(3), SLC25A5(2), SLC25A6(2), SLC8A1(10), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(2), TACR1(2), TACR2(4), TACR3(2), TNNC2(2), TRPC1(9), VDAC1(1), VDAC2(3), VDAC3(1)	385715203	925	415	918	307	208	216	154	206	140	1	0.673	1.000	1.000
284	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(8), ACVR1C(3), AKT1(2), AKT2(4), AKT3(5), ARRB1(1), ARRB2(1), ATF2(4), ATF4(3), BDNF(1), BRAF(5), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(17), CACNA1E(28), CACNA1F(16), CACNA1G(10), CACNA1H(10), CACNA1I(6), CACNA1S(8), CACNA2D1(7), CACNA2D2(8), CACNA2D3(9), CACNA2D4(4), CACNB1(3), CACNB2(2), CACNB3(4), CACNB4(1), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(2), CACNG6(1), CACNG7(3), CACNG8(1), CASP3(1), CD14(1), CDC25B(3), CHUK(7), CRK(1), CRKL(1), DAXX(2), DUSP1(1), DUSP10(9), DUSP16(6), DUSP2(1), DUSP4(1), DUSP6(1), DUSP7(3), DUSP9(2), EGF(5), EGFR(5), ELK1(4), ELK4(1), FAS(1), FASLG(2), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(1), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(11), FGFR3(3), FGFR4(3), FLNA(17), FLNB(15), FLNC(21), GNA12(2), HRAS(2), IKBKB(5), IL1A(1), IL1R1(1), IL1R2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP4K1(6), MAP4K2(2), MAP4K3(2), MAP4K4(7), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAPT(3), MAX(2), MEF2C(4), MKNK1(2), MKNK2(4), MOS(3), MRAS(2), MYC(1), NF1(29), NFATC2(4), NFATC4(6), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(2), NTRK1(8), NTRK2(5), PAK1(3), PAK2(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PPM1A(2), PPM1B(3), PPP3CA(5), PPP3CB(2), PPP3R1(1), PPP5C(3), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTPN5(4), PTPN7(2), PTPRR(4), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF2(7), RASA1(2), RASA2(4), RASGRF1(12), RASGRF2(5), RASGRP2(5), RASGRP3(2), RASGRP4(5), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KA6(6), SOS1(5), SOS2(6), SRF(1), STK3(2), STK4(3), TAOK1(5), TAOK2(7), TAOK3(5), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF1A(4), TRAF2(1), TRAF6(4), ZAK(4)	404731322	834	398	823	273	170	199	131	158	173	3	0.902	1.000	1.000
285	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(3), ACTN1(5), ACTN2(10), ACTN4(7), APC(23), ARAF(5), ARHGEF1(10), ARHGEF12(11), ARHGEF4(6), ARHGEF6(6), ARHGEF7(8), ARPC1A(3), ARPC1B(2), ARPC2(5), ARPC5(1), ARPC5L(3), BAIAP2(2), BCAR1(6), BDKRB1(4), BDKRB2(4), BRAF(5), CD14(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CRK(1), CRKL(1), CYFIP1(5), CYFIP2(12), DIAPH1(5), DIAPH2(9), DIAPH3(6), DOCK1(8), EGF(5), EGFR(5), EZR(1), F2(2), F2R(4), FGD1(1), FGD3(4), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(1), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(11), FGFR3(3), FGFR4(3), FN1(9), GIT1(3), GNA12(2), GNA13(1), GSN(2), HRAS(2), IQGAP1(7), IQGAP2(8), IQGAP3(10), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(4), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(7), ITGB3(4), ITGB4(8), ITGB5(2), ITGB6(6), ITGB7(5), ITGB8(4), LIMK1(7), LIMK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MOS(3), MRAS(2), MSN(4), MYH10(14), MYH14(13), MYH9(21), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), NCKAP1(9), NCKAP1L(8), NRAS(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PDGFB(2), PDGFRA(6), PDGFRB(7), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PPP1CB(1), PPP1R12A(7), PPP1R12B(4), PTK2(7), RAF1(4), RDX(3), RHOA(6), ROCK1(8), ROCK2(9), SCIN(4), SLC9A1(4), SOS1(5), SOS2(6), SSH1(4), SSH2(5), SSH3(4), TIAM1(7), TIAM2(10), VAV1(6), VAV2(3), VAV3(7), VCL(6), WAS(7), WASF1(6), WASF2(3), WASL(4)	390721238	792	354	778	270	157	205	116	153	158	3	0.993	1.000	1.000
286	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(5), ACTG1(8), COL11A1(8), COL11A2(5), COL17A1(9), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(10), COL4A2(10), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(12), COL6A1(3), COL6A2(3), COL6A3(15), COL6A6(14), COMP(5), DSC1(3), DSC2(12), DSC3(3), DSG1(4), DSG2(4), DSG3(8), DSG4(5), FN1(9), GJA1(4), GJA10(3), GJA4(1), GJA5(4), GJA8(2), GJA9(1), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJD2(2), GJD4(2), IBSP(5), ITGA6(4), ITGB4(8), KRT1(6), KRT10(1), KRT12(1), KRT13(2), KRT14(4), KRT15(1), KRT16(1), KRT17(8), KRT18(3), KRT19(6), KRT2(5), KRT20(2), KRT23(3), KRT24(2), KRT25(5), KRT27(1), KRT28(5), KRT3(4), KRT31(2), KRT32(4), KRT33A(1), KRT33B(1), KRT34(3), KRT35(2), KRT36(2), KRT37(1), KRT38(1), KRT39(1), KRT4(3), KRT40(1), KRT5(3), KRT6A(1), KRT6B(3), KRT6C(1), KRT7(1), KRT71(1), KRT72(3), KRT73(5), KRT74(1), KRT75(4), KRT76(2), KRT78(3), KRT79(2), KRT8(2), KRT81(3), KRT82(5), KRT83(4), KRT84(3), KRT85(3), KRT86(4), KRT9(3), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(3), LMNA(4), LMNB1(2), LMNB2(3), NES(14), RELN(26), SPP1(2), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(8), TNN(10), TNR(10), TNXB(16), VIM(2), VTN(3), VWF(11)	348150035	668	347	661	222	130	155	146	116	119	2	0.951	1.000	1.000
287	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), ANXA6(5), ARRB1(1), ARRB2(1), ATP1A4(13), ATP1B1(3), ATP1B3(1), ATP2A2(3), ATP2A3(1), ATP2B1(14), ATP2B2(9), ATP2B3(9), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(17), CACNA1E(28), CACNA1S(8), CACNB1(3), CACNB3(4), CALM2(1), CALR(1), CAMK1(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), CASQ1(2), CASQ2(6), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), GJA1(4), GJA4(1), GJA5(4), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GNA11(3), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), ITPR1(15), ITPR2(18), ITPR3(14), KCNB1(7), KCNJ3(2), KCNJ5(1), MIB1(7), NME7(4), PEA15(1), PKIA(1), PKIG(2), PLCB3(2), PLN(1), PRKACA(3), PRKACB(1), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(8), PRKCZ(2), PRKD1(5), RGS1(2), RGS10(1), RGS11(1), RGS14(4), RGS16(3), RGS17(3), RGS20(4), RGS3(7), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(30), RYR2(53), RYR3(43), SFN(1), SLC8A1(10), SLC8A3(4), USP5(7), YWHAB(2)	274371255	648	336	645	232	150	150	115	130	101	2	0.944	1.000	1.000
288	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	232	ADCYAP1R1(4), ADORA1(3), ADORA2A(3), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2B(4), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), C5AR1(3), CALCR(2), CALCRL(3), CCKAR(3), CCKBR(2), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CNR1(1), CNR2(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GABBR1(4), GABBR2(4), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(5), GABRB1(3), GABRB2(5), GABRB3(1), GABRD(1), GABRE(2), GABRG1(7), GABRG2(3), GABRG3(4), GABRP(1), GABRQ(5), GABRR1(2), GALR1(1), GALR2(2), GALR3(1), GH2(2), GHR(5), GHRHR(4), GHSR(2), GIPR(1), GLP1R(2), GLP2R(3), GLRA2(2), GLRA3(2), GLRB(1), GPR156(4), GPR35(1), GPR50(4), GPR63(3), GPR83(5), GRIA1(9), GRIA2(3), GRIA3(16), GRIA4(7), GRID1(12), GRID2(10), GRIK1(11), GRIK2(12), GRIK3(6), GRIK4(3), GRIK5(5), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRIN3A(10), GRIN3B(3), GRM1(9), GRM2(3), GRM3(9), GRM4(3), GRM5(4), GRM6(2), GRM7(2), GRM8(5), GRPR(3), GZMA(3), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HRH4(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(5), HTR5A(4), LEP(1), LEPR(7), LHCGR(10), MAS1(2), MC1R(1), MC2R(2), MC3R(3), MC4R(2), MCHR1(1), MCHR2(3), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPBWR1(3), NPFFR2(7), NPY1R(5), NPY2R(3), NR3C1(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(3), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), P2RY1(4), P2RY10(7), P2RY11(1), P2RY13(4), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(8), PRLHR(2), PRLR(4), PRSS3(3), PTAFR(1), PTGDR(2), PTGER3(2), PTGER4(1), PTGFR(1), PTH2R(2), RXFP1(4), RXFP2(3), SSTR2(1), SSTR3(2), SSTR4(1), SSTR5(1), TAAR1(3), TAAR2(4), TAAR5(4), TAAR6(2), TAAR8(1), TACR1(2), TACR2(4), TACR3(2), THRA(3), THRB(2), TRPV1(1), TSHR(7), VIPR1(1), VIPR2(3)	304644677	674	331	673	232	148	162	130	155	77	2	0.456	1.000	1.000
289	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTB(5), ACTG1(8), ACTN1(5), ACTN2(10), ACTN4(7), AKT1(2), AKT2(4), AKT3(5), AMOTL1(6), ASH1L(19), CASK(10), CDK4(1), CGN(7), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CRB3(1), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTTN(2), EPB41(5), EPB41L1(6), EPB41L2(7), EPB41L3(10), EXOC3(4), EXOC4(9), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), HCLS1(2), HRAS(2), IGSF5(3), INADL(11), LLGL1(5), LLGL2(2), MAGI1(15), MAGI2(9), MAGI3(7), MLLT4(19), MPDZ(13), MPP5(3), MRAS(2), MYH1(13), MYH10(14), MYH11(12), MYH13(12), MYH14(13), MYH15(16), MYH2(10), MYH3(5), MYH4(8), MYH6(11), MYH7(20), MYH7B(11), MYH8(15), MYH9(21), MYL5(3), MYL7(1), MYL9(1), NRAS(2), OCLN(3), PARD3(8), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(4), PPP2R3B(3), PPP2R4(4), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(8), PRKCZ(2), RAB13(3), RAB3B(1), RHOA(6), SPTAN1(12), SRC(1), SYMPK(8), TJAP1(2), TJP1(8), TJP2(4), TJP3(4), VAPA(2), YES1(2), ZAK(4)	276748043	609	316	599	177	120	156	87	116	126	4	0.790	1.000	1.000
290	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(7), CD36(4), CD44(3), CD47(2), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(10), COL4A2(10), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(12), COL6A1(3), COL6A2(3), COL6A3(15), COL6A6(14), DAG1(2), FN1(9), FNDC1(10), FNDC3A(5), GP5(3), GP6(1), HMMR(4), HSPG2(14), IBSP(5), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(2), ITGB6(6), ITGB7(5), ITGB8(4), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(3), RELN(26), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SPP1(2), SV2A(4), SV2B(4), SV2C(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(8), TNN(10), TNR(10), TNXB(16), VTN(3), VWF(11)	313136894	576	306	568	201	103	135	116	105	114	3	0.989	1.000	1.000
291	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(3), ACTA2(3), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ARRB1(1), ARRB2(1), ATF1(3), ATF2(4), ATF3(2), ATF4(3), ATF5(1), ATP2A2(3), ATP2A3(1), CACNB3(4), CALCA(1), CALM2(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CNN1(3), CNN2(1), CORIN(6), CRHR1(3), DGKZ(1), ETS2(7), GABPA(1), GABPB2(2), GBA2(4), GJA1(4), GNAQ(1), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), GSTO1(1), GUCY1A3(2), IGFBP2(1), IGFBP4(1), IGFBP6(1), IL6(1), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), MIB1(7), MYLK2(5), NFKB1(5), NOS1(13), NOS3(3), OXTR(1), PDE4B(10), PDE4D(8), PKIA(1), PKIG(2), PLCB3(2), PLCD1(3), PLCG1(8), PLCG2(8), PRKACA(3), PRKACB(1), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCH(3), PRKCQ(8), PRKCZ(2), PRKD1(5), RAMP3(1), RGS1(2), RGS10(1), RGS11(1), RGS14(4), RGS16(3), RGS17(3), RGS20(4), RGS3(7), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(30), RYR2(53), RYR3(43), SFN(1), SLC8A1(10), SP1(6), TNXB(16), USP5(7), YWHAB(2)	244957224	549	297	546	201	127	131	91	105	92	3	0.987	1.000	1.000
292	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(6), ABLIM1(2), ABLIM2(3), ABLIM3(6), ARHGEF12(11), CDK5(2), CFL1(1), CFL2(1), CXCR4(3), DCC(14), DPYSL2(2), DPYSL5(4), EFNA1(2), EFNA3(3), EFNA4(1), EFNA5(1), EFNB1(1), EFNB2(2), EFNB3(3), EPHA1(8), EPHA2(3), EPHA3(7), EPHA4(5), EPHA5(7), EPHA6(6), EPHA7(8), EPHA8(2), EPHB1(12), EPHB2(5), EPHB3(5), EPHB4(4), EPHB6(5), FES(4), GNAI1(2), GNAI2(2), GNAI3(1), GSK3B(2), HRAS(2), ITGB1(5), L1CAM(10), LIMK1(7), LIMK2(3), LRRC4C(4), MAPK1(1), MAPK3(1), MET(10), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NGEF(3), NRAS(2), NRP1(7), NTN1(1), NTN4(1), NTNG1(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PLXNA1(12), PLXNA2(12), PLXNA3(9), PLXNB1(4), PLXNB2(8), PLXNB3(5), PLXNC1(6), PPP3CA(5), PPP3CB(2), PPP3R1(1), PTK2(7), RASA1(2), RGS3(7), RHOA(6), RND1(2), ROBO1(13), ROBO2(11), ROBO3(6), ROCK1(8), ROCK2(9), SEMA3A(5), SEMA3C(6), SEMA3D(4), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(4), SEMA4C(2), SEMA4D(8), SEMA4F(9), SEMA4G(6), SEMA5A(12), SEMA5B(5), SEMA6A(9), SEMA6C(5), SEMA6D(4), SEMA7A(2), SLIT1(2), SLIT2(11), SLIT3(5), SRGAP1(10), SRGAP2(9), SRGAP3(4), UNC5A(1), UNC5B(5), UNC5C(3), UNC5D(14)	271540218	554	286	550	185	104	139	113	98	100	0	0.912	1.000	1.000
293	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	ACVR1B(8), ACVR2A(8), ACVR2B(1), AMHR2(3), BMP2(3), BMPR1A(1), BMPR1B(6), BMPR2(8), CCL11(1), CCL13(2), CCL15(1), CCL19(1), CCL2(1), CCL20(1), CCL21(1), CCL23(1), CCL26(1), CCL28(1), CCR1(3), CCR2(4), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CD40(2), CD40LG(1), CD70(1), CLCF1(1), CNTFR(2), CRLF2(1), CSF1(5), CSF1R(3), CSF2RA(2), CSF2RB(4), CSF3(2), CSF3R(6), CX3CL1(2), CX3CR1(2), CXCL10(1), CXCL2(1), CXCL6(3), CXCR3(6), CXCR4(3), CXCR6(1), EDA(2), EDA2R(3), EDAR(4), EGF(5), EGFR(5), EPO(1), EPOR(4), FAS(1), FASLG(2), FLT1(5), FLT3(4), FLT3LG(1), FLT4(3), GDF5(2), GH2(2), GHR(5), HGF(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL15(3), IL17A(1), IL17B(2), IL17RA(2), IL17RB(3), IL18(2), IL18R1(4), IL18RAP(1), IL19(1), IL1A(1), IL1R1(1), IL1R2(4), IL1RAP(10), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL25(2), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(1), IL6R(4), IL6ST(9), IL7(1), IL7R(4), IL9R(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), KDR(8), KIT(8), KITLG(3), LEP(1), LEPR(7), LIF(1), LIFR(9), LTA(2), LTBR(1), MET(10), MPL(2), NGFR(1), OSM(1), OSMR(5), PDGFB(2), PDGFRA(6), PDGFRB(7), PF4(1), PLEKHO2(1), PPBP(1), PRLR(4), RELT(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(3), TNFRSF13B(2), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(2), TNFSF12(3), TNFSF13(3), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF9(1), TPO(7), TSLP(1), VEGFA(1), VEGFC(2), XCL1(2), XCR1(3)	251235019	498	278	493	129	69	130	99	106	92	2	0.102	1.000	1.000
294	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(3), ACTN2(10), ACTN4(7), DMD(48), MYBPC1(4), MYBPC2(11), MYBPC3(3), MYH3(5), MYH6(11), MYH7(20), MYH8(15), MYL1(1), MYL9(1), MYOM1(7), NEB(38), TMOD1(1), TNNC2(2), TNNI3(5), TNNT1(2), TNNT3(3), TPM1(4), TPM2(2), TPM3(2), TTN(250), VIM(2)	206211095	460	265	458	123	77	147	66	96	70	4	0.534	1.000	1.000
295	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(4), AKT3(5), BCL2L1(1), CBL(4), CBLB(14), CBLC(7), CCND1(1), CCND2(2), CCND3(4), CISH(2), CLCF1(1), CNTFR(2), CREBBP(15), CRLF2(1), CSF2RA(2), CSF2RB(4), CSF3(2), CSF3R(6), EP300(13), EPO(1), EPOR(4), GH2(2), GHR(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL13RA2(5), IL15(3), IL19(1), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(1), IL6R(4), IL6ST(9), IL7(1), IL7R(4), IL9R(2), IRF9(4), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), LIF(1), LIFR(9), MPL(2), MYC(1), OSM(1), OSMR(5), PIAS1(3), PIAS2(7), PIAS3(2), PIAS4(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRLR(4), PTPN11(1), SOCS2(1), SOCS4(2), SOCS5(1), SOS1(5), SOS2(6), SPRED1(7), SPRED2(1), SPRY1(7), SPRY2(2), SPRY3(6), STAM(3), STAM2(4), STAT1(4), STAT2(5), STAT3(5), STAT4(8), STAT5A(6), STAT5B(5), STAT6(7), TPO(7), TSLP(1), TYK2(7)	201501193	450	258	446	103	58	112	89	97	92	2	0.0387	1.000	1.000
296	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	125	ACACA(12), ACACB(10), AKT1(2), AKT2(4), AKT3(5), ARAF(5), BAD(1), BRAF(5), CALM2(1), CALML6(1), CBL(4), CBLB(14), CBLC(7), CRK(1), CRKL(1), ELK1(4), EXOC7(6), FASN(14), FBP1(2), FLOT1(2), FLOT2(2), FOXO1(2), G6PC(2), G6PC2(3), GCK(3), GSK3B(2), GYS1(8), GYS2(1), HRAS(2), IKBKB(5), INPP5D(4), INSR(11), IRS1(4), IRS4(7), LIPE(5), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MKNK1(2), MKNK2(4), NRAS(2), PCK1(5), PCK2(4), PDE3A(12), PDE3B(4), PDPK1(2), PFKL(1), PFKM(8), PFKP(6), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PKLR(5), PPARGC1A(6), PPP1CB(1), PPP1R3A(13), PPP1R3B(2), PPP1R3C(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCI(1), PRKCZ(2), PRKX(5), PTPRF(10), PYGB(4), PYGL(3), PYGM(5), RAF1(4), RAPGEF1(5), RHEB(1), RHOQ(2), RPS6(4), RPS6KB1(4), RPS6KB2(5), SH2B2(1), SHC1(2), SHC2(2), SHC3(1), SHC4(5), SLC2A4(1), SOCS2(1), SOCS4(2), SORBS1(7), SOS1(5), SOS2(6), SREBF1(3), TRIP10(4), TSC1(5), TSC2(6)	215973931	450	254	446	150	68	129	62	106	85	0	0.927	1.000	1.000
297	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	122	ALCAM(5), CADM1(2), CADM3(2), CD2(4), CD22(5), CD226(2), CD274(2), CD276(1), CD28(2), CD34(2), CD4(4), CD40(2), CD40LG(1), CD58(2), CD86(4), CD8A(3), CD8B(3), CD99(4), CDH15(2), CDH2(2), CDH3(1), CDH4(6), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CNTN1(12), CNTN2(8), CNTNAP1(11), CNTNAP2(11), CTLA4(1), ESAM(3), F11R(4), GLG1(6), HLA-A(3), HLA-B(3), HLA-C(6), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-F(3), HLA-G(1), ICAM1(2), ICAM2(1), ICAM3(3), ICOS(3), ICOSLG(6), ITGA4(6), ITGA6(4), ITGA8(10), ITGA9(7), ITGAL(4), ITGAM(6), ITGAV(7), ITGB1(5), ITGB2(7), ITGB7(5), ITGB8(4), L1CAM(10), MADCAM1(1), MAG(3), MPZ(1), MPZL1(3), NCAM1(7), NCAM2(4), NEGR1(2), NEO1(6), NFASC(10), NLGN1(7), NLGN2(7), NLGN3(11), NRCAM(12), NRXN1(11), NRXN2(12), NRXN3(10), OCLN(3), PDCD1(2), PTPRC(8), PTPRF(10), PTPRM(7), PVR(3), PVRL1(3), PVRL2(5), PVRL3(4), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SELE(2), SELL(6), SELP(10), SELPLG(2), SIGLEC1(6), SPN(2), VCAM1(7), VCAN(22)	198591378	484	252	478	161	75	130	91	99	87	2	0.857	1.000	1.000
298	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADK(2), ADSL(3), ADSS(3), ADSSL1(1), AK1(1), AK2(1), AK5(4), AK7(4), ALLC(4), AMPD1(10), AMPD2(1), AMPD3(7), ATIC(3), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(5), ENTPD1(4), ENTPD2(3), ENTPD3(1), ENTPD4(4), ENTPD5(5), ENTPD6(3), ENTPD8(1), FHIT(2), GART(3), GDA(2), GMPR2(1), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), ITPA(1), NME6(1), NME7(4), NPR1(4), NPR2(10), NT5C1A(2), NT5C1B(4), NT5C2(2), NT5E(4), NUDT2(1), NUDT5(1), NUDT9(2), PAICS(3), PAPSS1(2), PAPSS2(2), PDE10A(8), PDE11A(5), PDE1A(5), PDE1C(5), PDE2A(4), PDE3B(4), PDE4A(1), PDE4B(10), PDE4C(5), PDE4D(8), PDE5A(6), PDE7B(1), PDE8A(1), PDE8B(1), PDE9A(5), PFAS(6), PKLR(5), PNPT1(5), POLA1(15), POLA2(5), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(4), POLR3H(1), POLR3K(1), PPAT(5), PRIM1(1), PRPS2(1), PRUNE(4), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), XDH(9)	233113832	438	241	434	152	82	117	82	83	73	1	0.972	1.000	1.000
299	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC(23), AXIN1(5), AXIN2(5), BTRC(4), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CCND1(1), CCND2(2), CCND3(4), CER1(2), CHD8(15), CREBBP(15), CSNK1A1(3), CSNK1A1L(4), CSNK1E(4), CSNK2A1(3), CSNK2A2(1), CTBP1(1), CTBP2(1), CTNNB1(2), CUL1(2), DAAM1(8), DAAM2(5), DKK2(1), DKK4(4), DVL1(2), DVL3(1), EP300(13), FZD1(3), FZD10(2), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LRP5(4), LRP6(6), MAP3K7(3), MAPK10(4), MAPK8(2), MAPK9(1), MYC(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NKD1(1), NKD2(2), NLK(1), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PORCN(4), PPARD(2), PPP2CA(3), PPP2CB(2), PPP2R1A(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRICKLE1(2), PRICKLE2(6), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PSEN1(2), RHOA(6), ROCK1(8), ROCK2(9), RUVBL1(2), SENP2(1), SFRP1(3), SFRP2(2), SFRP4(2), SIAH1(3), SKP1(1), SMAD2(7), SMAD3(4), SMAD4(7), TBL1X(5), TCF7(3), TCF7L1(2), TCF7L2(3), VANGL1(2), VANGL2(8), WIF1(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1)	218343614	426	228	423	145	94	104	64	78	82	4	0.976	1.000	1.000
300	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ATF4(3), CACNA1C(17), CACNA1D(17), CACNA1F(16), CACNA1S(8), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), EGFR(5), ELK1(4), GNA11(3), GNAQ(1), GNAS(11), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(4), MMP2(3), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLD1(7), PLD2(2), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(5), PRKX(5), PTK2B(6), RAF1(4), SOS1(5), SOS2(6), SRC(1)	178896308	365	218	361	127	76	94	52	75	68	0	0.936	1.000	1.000
301	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	105	ACTN1(5), ACTN2(10), ACTN4(7), ARHGAP5(12), BCAR1(6), CD99(4), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(5), CXCR4(3), CYBB(2), ESAM(3), EZR(1), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), ICAM1(2), ITGA4(6), ITGAL(4), ITGAM(6), ITGB1(5), ITGB2(7), ITK(7), MAPK13(1), MAPK14(1), MLLT4(19), MMP2(3), MMP9(3), MSN(4), MYL5(3), MYL7(1), MYL9(1), NCF1(1), NCF2(7), NCF4(3), NOX1(4), NOX3(2), OCLN(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), PTK2B(6), PTPN11(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(5), RASSF5(4), RHOA(6), ROCK1(8), ROCK2(9), SIPA1(5), TXK(3), VAV1(6), VAV2(3), VAV3(7), VCAM1(7), VCL(6)	170332976	356	216	353	119	60	80	58	76	81	1	0.940	1.000	1.000
302	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), DRD1(1), DRD2(3), EGF(5), EGFR(5), GJA1(4), GJD2(2), GNA11(3), GNAI1(2), GNAI2(2), GNAI3(1), GNAQ(1), GNAS(11), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), HTR2A(5), HTR2C(5), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAP2K2(2), MAP2K5(1), MAP3K2(3), MAPK1(1), MAPK3(1), MAPK7(4), NPR1(4), NPR2(10), NRAS(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKG1(4), PRKG2(7), PRKX(5), RAF1(4), SOS1(5), SOS2(6), SRC(1), TJP1(8), TUBA1A(2), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(4)	186070990	379	215	375	123	87	96	55	81	60	0	0.723	1.000	1.000
303	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(5), BRAF(5), CACNA1A(16), CRHR1(3), GNA11(3), GNA12(2), GNA13(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GNAZ(3), GRIA1(9), GRIA2(3), GRIA3(16), GRID2(10), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), IGF1R(7), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NOS1(13), NOS3(3), NPR1(4), NPR2(10), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PPP2CA(3), PPP2CB(2), PPP2R1A(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(4), PRKCG(3), PRKG1(4), PRKG2(7), RAF1(4), RYR1(30)	157441078	359	212	357	93	78	93	63	67	57	1	0.0834	1.000	1.000
304	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(6), AMY2A(4), AMY2B(1), ASCC3(7), ATP13A2(3), DDX18(3), DDX23(4), DDX4(5), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(1), DDX54(2), DDX55(7), DDX56(2), DHX58(4), ENPP1(7), ENPP3(5), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(4), G6PC(2), G6PC2(3), GAA(2), GANC(4), GBA(2), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), IFIH1(4), LYZL1(1), MGAM(14), MOV10L1(6), NUDT5(1), NUDT8(1), PGM1(5), PGM3(2), PYGB(4), PYGL(3), PYGM(5), RAD54B(10), RAD54L(3), RUVBL2(1), SETX(18), SI(18), SKIV2L2(4), SMARCA2(11), SMARCA5(5), TREH(2), UGDH(1), UGP2(4), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UXS1(3)	178094313	324	207	323	104	42	89	52	86	55	0	0.909	1.000	1.000
305	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACTB(5), ACTG1(8), ACTN1(5), ACTN2(10), ACTN4(7), ACVR1B(8), ACVR1C(3), BAIAP2(2), CREBBP(15), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(5), EGFR(5), EP300(13), FARP2(9), FER(5), FGFR1(3), IGF1R(7), INSR(11), IQGAP1(7), LMO7(5), MAP3K7(3), MAPK1(1), MAPK3(1), MET(10), MLLT4(19), NLK(1), PARD3(8), PTPRB(11), PTPRF(10), PTPRJ(7), PTPRM(7), PVRL1(3), PVRL2(5), PVRL3(4), PVRL4(2), RHOA(6), SMAD2(7), SMAD3(4), SMAD4(7), SNAI1(2), SORBS1(7), SRC(1), SSX2IP(4), TCF7(3), TCF7L1(2), TCF7L2(3), TGFBR1(4), TGFBR2(4), TJP1(8), VCL(6), WAS(7), WASF1(6), WASF2(3), WASF3(5), WASL(4), YES1(2)	166770577	353	207	347	103	67	97	49	61	79	0	0.717	1.000	1.000
306	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(8), ACVRL1(1), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(8), BUB1(3), CDKL1(4), CDKL2(1), CDS1(3), CDS2(3), CLK1(2), CLK2(6), CLK4(3), COL4A3BP(4), CSNK2A1(3), CSNK2A2(1), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKQ(1), DGKZ(1), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(1), INPPL1(6), ITPKA(1), ITPKB(8), MAP3K10(3), MOS(3), NEK1(6), NEK3(3), OCRL(8), PAK4(3), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CB(8), PIK3CG(5), PIM2(4), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCG1(8), PLCG2(8), PLK3(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(8), PRKCZ(2), PRKD1(5), PRKG1(4), RAF1(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KB1(4), STK11(2), TGFBR1(4), VRK1(2)	159479586	335	206	331	93	58	81	42	68	83	3	0.626	1.000	1.000
307	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALM2(1), CALML6(1), CDS1(3), CDS2(3), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(1), DGKZ(1), FN3K(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(1), INPP5B(7), INPP5D(4), INPP5E(1), INPPL1(6), ITPK1(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), OCRL(8), PI4KA(9), PI4KB(5), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3C3(6), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(10), PRKCA(4), PRKCG(3), SYNJ1(3), SYNJ2(3)	172655949	350	204	346	107	62	90	47	74	76	1	0.790	1.000	1.000
308	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADK(2), ADSL(3), ADSS(3), AK1(1), AK2(1), AK5(4), ALLC(4), AMPD1(10), AMPD2(1), AMPD3(7), ATIC(3), ATP1B1(3), ATP5A1(3), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(5), ENTPD1(4), ENTPD2(3), FHIT(2), GART(3), GDA(2), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), ITPA(1), NPR1(4), NPR2(10), NT5E(4), NUDT2(1), PAICS(3), PAPSS1(2), PAPSS2(2), PDE1A(5), PDE4A(1), PDE4B(10), PDE4C(5), PDE4D(8), PDE5A(6), PDE6B(3), PDE6C(7), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(6), PKLR(5), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(2), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), PPAT(5), PRPS2(1), PRUNE(4), RRM1(4), RRM2(1)	181462803	342	204	338	117	63	91	61	65	61	1	0.942	1.000	1.000
309	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), AKAP1(3), AKAP10(1), AKAP11(13), AKAP12(10), AKAP2(6), AKAP3(6), AKAP4(8), AKAP6(16), AKAP7(1), AKAP8(4), AKAP9(24), ARHGEF1(10), CALM2(1), GNA11(3), GNA12(2), GNA13(1), GNA14(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GNG10(1), HRAS(2), IL18BP(2), ITPR1(15), KCNJ3(2), NRAS(2), PALM2(3), PDE1A(5), PDE1B(5), PDE1C(5), PDE4A(1), PDE4B(10), PDE4C(5), PDE4D(8), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(5), PRKACA(3), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(8), PRKCZ(2), PRKD1(5), PRKD3(6), RHOA(6), SLC9A1(4), USP5(7)	166760338	340	201	339	111	62	95	55	67	59	2	0.893	1.000	1.000
310	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(6), ANAPC1(9), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(4), ATM(23), ATR(13), BUB1(3), BUB1B(4), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND1(1), CCND2(2), CCND3(4), CCNE1(2), CCNE2(3), CCNH(2), CDC14A(3), CDC14B(1), CDC16(3), CDC20(1), CDC23(1), CDC25A(1), CDC25B(3), CDC25C(4), CDC6(4), CDC7(2), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(5), CREBBP(15), CUL1(2), E2F1(5), E2F2(1), E2F3(3), EP300(13), ESPL1(13), GSK3B(2), HDAC1(6), HDAC2(2), MAD1L1(4), MAD2L1(4), MAD2L2(2), MCM2(3), MCM3(3), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(24), PTTG1(1), RBL1(6), SFN(1), SKP1(1), SKP2(2), SMAD2(7), SMAD3(4), SMAD4(7), SMC1A(10), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), WEE1(4), YWHAB(2), YWHAG(1), YWHAZ(3)	189570521	340	199	336	83	47	100	46	67	79	1	0.473	1.000	1.000
311	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(11), ABCA10(15), ABCA12(12), ABCA13(32), ABCA2(4), ABCA3(10), ABCA4(12), ABCA5(8), ABCA6(9), ABCA7(10), ABCA8(14), ABCA9(13), ABCB1(9), ABCB10(9), ABCB11(13), ABCB4(10), ABCB5(5), ABCB6(7), ABCB7(7), ABCB8(6), ABCB9(1), ABCC1(8), ABCC10(7), ABCC11(7), ABCC12(10), ABCC2(7), ABCC3(8), ABCC4(10), ABCC5(10), ABCC6(5), ABCC8(12), ABCC9(13), ABCD1(4), ABCD2(4), ABCD3(4), ABCD4(2), ABCG1(3), ABCG2(1), ABCG4(7), ABCG5(2), ABCG8(3), CFTR(14), TAP1(2)	168107572	360	198	358	118	48	107	64	78	61	2	0.660	1.000	1.000
312	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	148	ADORA1(3), ADORA2A(3), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(4), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CCRL2(4), CHML(4), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CMKLR1(4), CNR1(1), CNR2(1), CX3CR1(2), CXCR3(6), CXCR4(3), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(1), GHSR(2), GNB2L1(2), GPR17(2), GPR173(1), GPR174(4), GPR3(2), GPR35(1), GPR37(5), GPR37L1(1), GPR50(4), GPR6(2), GPR63(3), GPR83(5), GPR85(2), GPR87(2), GRPR(3), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(5), HTR5A(4), LHCGR(10), MAS1(2), MC1R(1), MC3R(3), MC4R(2), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPY1R(5), NPY2R(3), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(3), OXTR(1), P2RY1(4), P2RY10(7), P2RY11(1), P2RY13(4), P2RY2(1), P2RY6(1), PTAFR(1), PTGDR(2), PTGER4(1), PTGFR(1), RGR(1), RHO(2), RRH(1), SSTR2(1), SSTR3(2), SSTR4(1)	154328412	321	197	322	124	77	66	55	90	32	1	0.671	1.000	1.000
313	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(5), BCAR1(6), CAPN1(8), CAPN10(4), CAPN11(3), CAPN2(8), CAPN3(2), CAPN6(3), CAPN7(2), CAPN9(1), CAV1(4), CRK(1), DOCK1(8), GIT2(1), ILK(3), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(4), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(7), ITGB3(4), ITGB4(8), ITGB5(2), ITGB6(6), ITGB7(5), ITGB8(4), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK10(4), MAPK4(6), MAPK6(6), MAPK7(4), MYLK2(5), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PDPK1(2), PIK3R2(4), PTK2(7), RAP1B(1), RAPGEF1(5), RHO(2), ROCK1(8), ROCK2(9), SDCCAG8(6), SEPP1(2), SHC1(2), SHC3(1), SORBS1(7), SOS1(5), SRC(1), TLN1(15), TNS1(6), VAV2(3), VAV3(7), VCL(6), ZYX(1)	192659698	347	196	346	120	63	94	55	70	63	2	0.951	1.000	1.000
314	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CREB1(1), CREB3L1(3), CREB3L2(3), CREB3L3(6), CREB3L4(2), CREBBP(15), CTNNB1(2), DCT(4), DVL1(2), DVL3(1), EDN1(5), EDNRB(2), EP300(13), FZD1(3), FZD10(2), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GSK3B(2), HRAS(2), KIT(8), KITLG(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MC1R(1), MITF(3), NRAS(2), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), TCF7(3), TCF7L1(2), TCF7L2(3), TYR(5), TYRP1(7), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1)	147930181	314	192	311	110	74	69	54	59	58	0	0.942	1.000	1.000
315	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(2), AKT2(4), AKT3(5), BCL10(3), CARD11(7), CBL(4), CBLB(14), CBLC(7), CD28(2), CD3E(3), CD3G(3), CD4(4), CD40LG(1), CD8A(3), CD8B(3), CDK4(1), CHUK(7), CTLA4(1), GRAP2(2), HRAS(2), ICOS(3), IFNG(2), IKBKB(5), IL4(1), ITK(7), JUN(3), LAT(1), LCK(2), LCP2(2), MALT1(3), MAP3K8(4), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NRAS(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PDCD1(2), PDK1(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKCQ(8), PTPRC(8), RHOA(6), SOS1(5), SOS2(6), TEC(6), VAV1(6), VAV2(3), VAV3(7), ZAP70(3)	135703938	291	188	290	92	44	79	51	56	60	1	0.900	1.000	1.000
316	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(5), ADCY8(6), ARAF(5), ATF4(3), BRAF(5), CACNA1C(17), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), CREBBP(15), EP300(13), GNAQ(1), GRIA1(9), GRIA2(3), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NRAS(2), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PPP1CB(1), PPP1R12A(7), PPP1R1A(5), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6)	144713447	323	186	320	99	69	86	50	65	53	0	0.535	1.000	1.000
317	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(6), BDKRB1(4), BDKRB2(4), C1QA(1), C1QB(1), C1R(6), C1S(1), C2(3), C3(8), C3AR1(3), C4BPA(4), C4BPB(1), C5(5), C5AR1(3), C6(8), C7(8), C8A(2), C8B(3), C8G(1), C9(5), CD46(2), CD55(3), CD59(1), CFB(1), CFH(13), CFI(1), CPB2(4), CR1(12), CR2(5), F10(5), F12(2), F13A1(5), F13B(5), F2(2), F2R(4), F5(25), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(2), KNG1(4), MASP1(4), MASP2(2), MBL2(2), PLAT(6), PLAUR(2), PLG(7), PROC(3), PROS1(4), SERPINA1(4), SERPINA5(5), SERPINC1(6), SERPIND1(1), SERPINE1(5), SERPINF2(2), SERPING1(3), TFPI(3), THBD(2), VWF(11)	128452543	283	184	281	82	42	68	65	58	49	1	0.610	1.000	1.000
318	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(5), BID(3), BRAF(5), CASP3(1), CD244(3), CD48(2), FAS(1), FASLG(2), FCGR3A(3), HLA-A(3), HLA-B(3), HLA-C(6), HLA-G(1), HRAS(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), ITGAL(4), ITGB2(7), KIR2DL3(2), KIR3DL1(3), KIR3DL2(6), KLRC1(5), KLRC3(1), KLRD1(1), KLRK1(2), LAT(1), LCK(2), LCP2(2), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MICA(3), MICB(2), NCR1(3), NCR2(2), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NRAS(2), PAK1(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRF1(2), PRKCA(4), PRKCG(3), PTK2B(6), PTPN11(1), RAF1(4), SHC1(2), SHC2(2), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SYK(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(6), VAV2(3), VAV3(7), ZAP70(3)	151677324	298	184	296	103	38	93	53	61	52	1	0.923	1.000	1.000
319	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(6), ACTN1(5), ACTR2(2), ACTR3(2), AKT1(2), AKT2(4), AKT3(5), ANGPTL2(1), ARHGEF6(6), ARHGEF7(8), BCAR1(6), BRAF(5), CAV1(4), CDKN2A(1), CRK(1), CSE1L(6), DOCK1(8), EPHB2(5), GRB7(4), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGB3BP(3), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MRAS(2), MYLK(11), MYLK2(5), P4HB(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PIK3CB(8), PKLR(5), PLCG1(8), PLCG2(8), PTK2(7), RAF1(4), RALA(1), RHO(2), ROCK1(8), ROCK2(9), SHC1(2), SOS1(5), SOS2(6), SRC(1), TERF2IP(3), TLN1(15), TLN2(14), WAS(7), ZYX(1)	168408469	325	184	325	92	62	83	44	75	59	2	0.395	1.000	1.000
320	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(6), ATM(23), BUB1(3), BUB1B(4), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND2(2), CCND3(4), CCNE1(2), CCNE2(3), CCNH(2), CDAN1(2), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(1), CDC25B(3), CDC25C(4), CDC6(4), CDC7(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(5), DTX4(2), E2F1(5), E2F2(1), E2F3(3), E2F4(2), E2F6(2), EP300(13), ESPL1(13), GSK3B(2), HDAC1(6), HDAC2(2), HDAC3(1), HDAC4(5), HDAC5(6), HDAC6(16), HDAC8(3), MAD1L1(4), MAD2L1(4), MAD2L2(2), MCM2(3), MCM3(3), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MPEG1(4), MPL(2), PLK1(2), PRKDC(24), PTPRA(6), PTTG1(1), RBL1(6), SKP2(2), SMAD4(7), TBC1D8(7), TFDP1(3), TGFB1(2), WEE1(4)	154075347	296	183	293	78	37	86	44	56	72	1	0.632	1.000	1.000
321	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	79	ABL1(6), ABL2(6), AKT1(2), AKT2(4), AKT3(5), ARAF(5), AREG(1), BAD(1), BRAF(5), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CBL(4), CBLB(14), CBLC(7), CDKN1A(1), CRK(1), CRKL(1), EGF(5), EGFR(5), ELK1(4), ERBB3(17), ERBB4(13), GAB1(2), GSK3B(2), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NCK2(1), NRAS(2), NRG1(2), NRG2(4), NRG3(6), NRG4(1), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), RAF1(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SHC2(2), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SRC(1), STAT5A(6), STAT5B(5), TGFA(1)	132969148	292	181	290	85	49	78	44	68	53	0	0.625	1.000	1.000
322	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG1(2), ALG10(3), ALG10B(5), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG6(2), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT5(4), B4GALT7(1), C1GALT1(3), C1GALT1C1(3), CHPF(2), CHST1(4), CHST11(1), CHST2(4), CHST3(1), CHST4(1), CHST7(1), CHSY1(3), DAD1(1), DDOST(2), DPAGT1(3), EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), FUT11(3), FUT8(3), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(4), GALNT8(5), GALNT9(5), GALNTL5(7), GANAB(10), GCNT3(1), GCNT4(3), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), MAN1A1(6), MAN1A2(2), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(3), MGAT4B(4), MGAT5(3), MGAT5B(8), NDST1(4), NDST2(1), NDST3(5), OGT(5), RPN1(4), RPN2(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(4), ST3GAL4(2), ST6GAL1(3), ST6GALNAC1(5), STT3B(3), UST(2), WBSCR17(7), XYLT1(4), XYLT2(5)	151831110	303	180	301	101	59	73	46	69	53	3	0.880	1.000	1.000
323	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1B(8), ACVR1C(3), ACVR2A(8), ACVR2B(1), ACVRL1(1), AMHR2(3), BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(1), BMPR1A(1), BMPR1B(6), BMPR2(8), CHRD(5), COMP(5), CREBBP(15), CUL1(2), DCN(2), E2F4(2), EP300(13), FST(3), GDF5(2), GDF6(1), ID1(1), ID2(2), ID3(1), IFNG(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), LEFTY2(1), LTBP1(9), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), NOG(1), PITX2(5), PPP2CA(3), PPP2CB(2), PPP2R1A(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(6), RHOA(6), ROCK1(8), ROCK2(9), RPS6KB1(4), RPS6KB2(5), SKP1(1), SMAD1(1), SMAD2(7), SMAD3(4), SMAD4(7), SMAD5(2), SMAD7(1), SMAD9(4), SMURF1(3), SMURF2(5), SP1(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), THBS1(8), THBS2(2), THBS3(5), THBS4(4), ZFYVE16(4), ZFYVE9(4)	138057261	268	177	263	70	51	64	28	59	66	0	0.486	1.000	1.000
324	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(19), ASH2L(4), CARM1(4), CTCFL(5), DOT1L(8), EED(4), EHMT1(9), EHMT2(5), EZH1(3), EZH2(3), FBXO11(5), HCFC1(18), HSF4(1), JMJD6(2), KDM6A(16), MEN1(4), NSD1(13), OGT(5), PAXIP1(6), PPP1CB(1), PRDM2(8), PRDM6(1), PRDM7(2), PRDM9(6), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(3), SATB1(8), SETD1A(4), SETD1B(9), SETD2(18), SETD7(5), SETD8(3), SETDB1(11), SETDB2(2), SETMAR(2), SMYD3(5), STK38(4), SUV39H1(2), SUV39H2(1), SUV420H1(9), SUV420H2(2), SUZ12(7), WHSC1(6), WHSC1L1(5)	174527691	272	176	267	60	38	71	47	54	62	0	0.286	1.000	1.000
325	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(4), BRAF(5), CHUK(7), CREB1(1), DAXX(2), ELK1(4), HRAS(2), IKBKB(5), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP3K9(5), MAP4K1(6), MAP4K2(2), MAP4K3(2), MAP4K4(7), MAP4K5(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(6), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MKNK2(4), MYC(1), NFKB1(5), NFKBIA(3), PAK1(3), PAK2(2), RAF1(4), RELA(3), RIPK1(5), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SP1(6), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1)	131717665	255	166	251	64	50	75	27	48	55	0	0.213	1.000	1.000
326	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(5), BAD(1), CABIN1(8), CALM2(1), CAMK2B(2), CAMK4(5), CD3E(3), CD3G(3), CD69(2), CDKN1A(1), CNR1(1), CREBBP(15), CSNK2A1(3), CTLA4(1), EGR2(3), EGR3(4), EP300(13), FCER1A(4), FCGR3A(3), GATA4(2), GSK3A(5), GSK3B(2), HRAS(2), ICOS(3), IFNA1(1), IFNG(2), IL2RA(2), IL3(1), IL4(1), IL6(1), ITK(7), KPNA5(5), MAP2K7(1), MAPK14(1), MAPK8(2), MAPK9(1), MEF2A(6), MEF2D(3), MYF5(4), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB2(5), NFKBIB(1), NFKBIE(2), NUP214(11), OPRD1(3), P2RX7(3), PAK1(3), PPP3CB(2), PPP3R1(1), PTPRC(8), RELA(3), RPL13A(4), SFN(1), SLA(1), SP1(6), SP3(7), TGFB1(2), TRAF2(1), TRPV6(5), VAV1(6), VAV2(3), VAV3(7), XPO5(7)	126253940	252	162	251	69	33	61	44	55	59	0	0.523	1.000	1.000
327	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(8), CD14(1), CD19(6), CD1A(2), CD1B(5), CD1C(4), CD1D(3), CD1E(7), CD2(4), CD22(5), CD33(3), CD34(2), CD36(4), CD37(2), CD38(3), CD3E(3), CD3G(3), CD4(4), CD44(3), CD5(3), CD55(3), CD59(1), CD7(1), CD8A(3), CD8B(3), CD9(2), CR1(12), CR2(5), CSF1(5), CSF1R(3), CSF2RA(2), CSF3(2), CSF3R(6), DNTT(6), EPO(1), EPOR(4), FCER2(1), FCGR1A(5), FLT3(4), FLT3LG(1), GP5(3), HLA-DRB1(10), IL11(1), IL11RA(5), IL1A(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(1), IL6R(4), IL7(1), IL7R(4), IL9R(2), ITGA1(6), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGAM(6), ITGB3(4), KIT(8), KITLG(3), MME(1), MS4A1(1), TFRC(2), THPO(3), TPO(7)	116584579	261	160	261	81	35	68	53	57	47	1	0.743	1.000	1.000
328	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT1(2), AKT2(4), AKT3(5), CD14(1), CD40(2), CD86(4), CHUK(7), CXCL10(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(5), IKBKE(6), IL12B(2), IL6(1), IRAK1(3), IRAK4(3), IRF3(6), IRF5(2), JUN(3), LBP(1), LY96(1), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K7(3), MAP3K8(4), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), RELA(3), RIPK1(5), SPP1(2), STAT1(4), TBK1(1), TICAM1(2), TIRAP(1), TLR1(3), TLR2(3), TLR3(7), TLR4(15), TLR5(4), TLR7(9), TLR8(13), TLR9(2), TRAF3(3), TRAF6(4)	116916480	247	158	246	63	30	73	42	54	46	2	0.223	1.000	1.000
329	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(3), AKT1(2), AKT2(4), AKT3(5), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(3), BIRC2(3), BIRC3(4), CAPN1(8), CAPN2(8), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP9(2), CFLAR(1), CHUK(7), CSF2RB(4), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKB(5), IL1A(1), IL1R1(1), IL1RAP(10), IL3(1), IL3RA(3), IRAK1(3), IRAK2(4), IRAK3(2), IRAK4(3), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), NTRK1(8), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RELA(3), RIPK1(5), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(4), TRAF2(1)	110534671	234	153	231	52	31	74	41	39	49	0	0.0803	1.000	1.000
330	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(1), CDC40(3), CLK2(6), CLK3(4), CLK4(3), COL2A1(4), CPSF1(11), CPSF2(1), CPSF3(6), CPSF4(3), CSTF1(2), CSTF2(2), CSTF2T(4), CSTF3(8), DDX1(3), DDX20(4), DHX15(9), DHX16(2), DHX38(4), DHX8(7), DHX9(8), DICER1(8), DNAJC8(1), FUS(3), GIPC1(1), METTL3(2), NCBP1(1), NCBP2(1), NONO(2), NUDT21(1), NXF1(7), PABPN1(1), PAPOLA(4), POLR2A(6), PPM1G(2), PRPF18(2), PRPF3(5), PRPF4(3), PRPF4B(9), PRPF8(12), PSKH1(3), PTBP1(4), PTBP2(3), RBM17(1), RBM5(5), RNGTT(2), RNMT(1), RNPS1(2), SF3A1(2), SF3A2(1), SF3A3(1), SF3B2(5), SF3B4(3), SF3B5(1), SNRPA(1), SNRPB(2), SNRPD2(1), SNRPG(2), SNRPN(3), SPOP(5), SRPK1(3), SRPK2(5), SRRM1(5), SUPT5H(12), TXNL4A(1), U2AF1(1), U2AF2(1), XRN2(4)	145888031	246	149	246	60	31	69	43	54	47	2	0.454	1.000	1.000
331	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(10), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADIPOR1(1), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(4), AKT3(5), CAMKK1(3), CAMKK2(3), CD36(4), CHUK(7), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), G6PC(2), G6PC2(3), IKBKB(5), IRS1(4), IRS4(7), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), MAPK10(4), MAPK8(2), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NPY(1), PCK1(5), PCK2(4), PPARA(4), PPARGC1A(6), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(1), RELA(3), RXRA(2), RXRG(2), SLC2A4(1), STAT3(5), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1), TYK2(7)	113587289	234	148	231	77	44	52	39	43	54	2	0.864	1.000	1.000
332	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(1), INPP5B(7), INPP5E(1), INPPL1(6), IPMK(1), ISYNA1(1), ITPK1(1), ITPKA(1), ITPKB(8), MINPP1(3), OCRL(8), PI4KA(9), PI4KB(5), PIK3C3(6), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(10), SYNJ1(3), SYNJ2(3)	100192795	212	139	211	56	40	55	31	36	49	1	0.353	1.000	1.000
333	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(1), ALG6(2), CCKBR(2), CCR2(4), CCR3(2), CCR5(1), CELSR1(11), CELSR2(14), CELSR3(12), CHRM2(6), CHRM3(3), CIDEB(2), CXCR3(6), EDNRA(3), EMR2(8), EMR3(7), F2R(4), FSHR(9), GHRHR(4), GPR116(7), GPR132(1), GPR133(6), GPR135(1), GPR143(4), GPR17(2), GPR55(3), GPR56(1), GPR61(2), GPR84(7), GRM1(9), GRPR(3), HRH4(2), LGR6(4), LPHN2(11), LPHN3(6), P2RY11(1), P2RY13(4), PTGFR(1), SMO(5), SSTR2(1), TAAR5(4), TSHR(7), VN1R1(1)	87337491	194	138	195	70	28	48	32	55	31	0	0.740	1.000	1.000
334	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(2), AKT2(4), AKT3(5), BCL10(3), BLNK(1), BTK(7), CARD11(7), CD19(6), CD22(5), CD72(4), CD79B(2), CHUK(7), CR2(5), GSK3B(2), HRAS(2), IFITM1(1), IKBKB(5), INPP5D(4), JUN(3), LILRB3(4), LYN(6), MALT1(3), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NRAS(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG2(8), PPP3CA(5), PPP3CB(2), PPP3R1(1), RASGRP3(2), SYK(4), VAV1(6), VAV2(3), VAV3(7)	98141311	204	138	203	69	37	54	33	42	38	0	0.877	1.000	1.000
335	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), AKT2(4), AKT3(5), BTK(7), FCER1A(4), GAB2(5), HRAS(2), IL3(1), IL4(1), INPP5D(4), LAT(1), LCP2(2), LYN(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(3), NRAS(2), PDK1(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCG1(8), PLCG2(8), PRKCA(4), PRKCD(5), PRKCE(8), RAF1(4), SOS1(5), SOS2(6), SYK(4), VAV1(6), VAV2(3), VAV3(7)	94267233	192	135	192	45	33	47	30	42	40	0	0.131	1.000	1.000
336	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	AK3(2), CAD(15), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(1), DUT(1), ENTPD1(4), ENTPD3(1), ENTPD4(4), ENTPD5(5), ENTPD6(3), ENTPD8(1), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(4), NT5C2(2), NT5E(4), NUDT2(1), PNPT1(5), POLA1(15), POLA2(5), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(4), POLR3H(1), POLR3K(1), PRIM1(1), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), TK1(1), TK2(1), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(2), UPP1(3), UPRT(3)	115898658	198	132	196	75	33	55	31	42	36	1	0.987	1.000	1.000
337	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), AKT2(4), AKT3(5), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), CD22(5), CR2(5), DAG1(2), FLOT1(2), FLOT2(2), GSK3A(5), GSK3B(2), INPP5D(4), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), MAP4K1(6), MAPK1(1), MAPK3(1), NFATC1(5), NFATC2(4), NR0B2(2), PDK1(2), PIK3CD(6), PLCG2(8), PPP1R13B(4), PPP3CA(5), PPP3CB(2), PTPRC(8), RAF1(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6)	97846862	190	128	189	56	35	50	26	53	26	0	0.445	1.000	1.000
338	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(4), ADCY6(2), ADCY8(6), CACNA1A(16), CACNA1B(14), GNAS(11), GNAT3(1), GNB1(2), GNB3(3), GRM4(3), ITPR3(14), KCNB1(7), PDE1A(5), PLCB2(7), PRKACA(3), PRKACB(1), PRKACG(3), PRKX(5), SCNN1A(3), SCNN1B(2), SCNN1G(1), TAS1R1(2), TAS1R2(4), TAS1R3(1), TAS2R1(4), TAS2R10(4), TAS2R13(2), TAS2R14(2), TAS2R16(5), TAS2R3(3), TAS2R38(2), TAS2R39(1), TAS2R40(2), TAS2R41(2), TAS2R42(2), TAS2R43(4), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R8(2), TAS2R9(2), TRPM5(10)	80499015	172	127	170	51	34	43	31	34	30	0	0.341	1.000	1.000
339	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(28), B3GALT4(2), CDR1(2), DGKI(7), IL6ST(9), RPL10(2), RPL12(1), RPL13A(4), RPL15(1), RPL17(1), RPL18(1), RPL18A(4), RPL19(2), RPL23(1), RPL24(1), RPL26(1), RPL3(2), RPL31(1), RPL32(1), RPL35(1), RPL36(1), RPL3L(3), RPL4(1), RPL41(1), RPL5(2), RPL7(1), RPL8(2), RPL9(1), RPLP0(3), RPLP2(1), RPS10(1), RPS12(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS29(1), RPS4X(2), RPS5(6), RPS6(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), RPS8(1), SLC36A2(5), TBC1D10C(4), TSPAN9(3), UBA52(2), UBC(12)	75185541	168	124	166	50	36	47	32	27	25	1	0.672	1.000	1.000
340	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(11), ATM(23), ATR(13), BAI1(10), BAX(3), BBC3(1), BID(3), CASP3(1), CASP9(2), CCNB1(3), CCNB3(14), CCND1(1), CCND2(2), CCND3(4), CCNE1(2), CCNE2(3), CCNG2(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(5), DDB2(2), EI24(3), FAS(1), GTSE1(10), MDM2(3), MDM4(3), PERP(1), PPM1D(2), RCHY1(2), RFWD2(2), RPRM(1), RRM2(1), RRM2B(1), SERPINE1(5), SESN2(2), SESN3(1), SFN(1), SIAH1(3), STEAP3(2), THBS1(8), TNFRSF10B(1), TP53I3(5), TP73(2), TSC2(6)	87208513	180	123	176	44	24	52	23	30	50	1	0.455	1.000	1.000
341	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	APH1A(2), CREBBP(15), CTBP1(1), CTBP2(1), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(3), DTX3(3), DTX3L(4), DTX4(2), DVL1(2), DVL3(1), EP300(13), HDAC1(6), HDAC2(2), HES1(1), JAG1(9), JAG2(1), MAML1(3), MAML2(4), MAML3(7), NCOR2(8), NCSTN(6), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), NUMB(5), NUMBL(3), PSEN1(2), PSEN2(4), PSENEN(2), PTCRA(3), RBPJL(5), RFNG(2), SNW1(2)	90168295	185	123	184	67	41	34	40	29	41	0	0.958	1.000	1.000
342	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(2), AKT2(4), AKT3(5), BAD(1), BCL2L1(1), CDK2(2), CDKN2A(1), CREB1(1), CREB5(5), EBP(1), ERBB4(13), F2RL2(2), GAB1(2), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), MET(10), MYC(1), NOLC1(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PARD3(8), PARD6A(1), PDK1(2), PIK3CD(6), PPP1R13B(4), PREX1(9), PTK2(7), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SLC2A4(1), SOS1(5), SOS2(6), TSC1(5), TSC2(6), YWHAB(2), YWHAG(1), YWHAZ(3)	100576045	190	123	189	62	33	54	27	36	39	1	0.872	1.000	1.000
343	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(2), AKT2(4), AKT3(5), BAD(1), CASP9(2), HRAS(2), KDR(8), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(2), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NOS3(3), NRAS(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKCA(4), PRKCG(3), PTGS2(6), PTK2(7), RAF1(4), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(2), SRC(1), VEGFA(1)	93264695	180	122	180	63	31	49	36	35	29	0	0.878	1.000	1.000
344	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	60	ATM(23), CCNB1(3), CCND1(1), CCND2(2), CCND3(4), CCNE1(2), CCNE2(3), CCNG2(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK7(3), CDKN1A(1), CDKN2A(1), CREB3L1(3), CREB3L3(6), CREB3L4(2), E2F1(5), E2F2(1), E2F3(3), E2F4(2), E2F6(2), GBA2(4), MCM2(3), MCM3(3), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MNAT1(2), MYC(1), MYT1(10), NACA(8), POLA2(5), POLE(10), POLE2(2), PRIM1(1), RBL1(6), RPA1(1), RPA2(1), RPA3(2), TFDP1(3), TFDP2(4), TNXB(16), WEE1(4)	100735042	183	121	180	51	29	57	21	39	36	1	0.645	1.000	1.000
345	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), ACTR3(2), AKT1(2), AKT2(4), AKT3(5), ANGPTL2(1), ARHGAP1(2), ARHGAP4(4), ARHGEF11(6), BTK(7), CFL1(1), CFL2(1), GDI1(4), GDI2(2), INPPL1(6), ITPR1(15), ITPR2(18), ITPR3(14), LIMK1(7), MYLK(11), MYLK2(5), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PDK1(2), PIK3CD(6), PIK3CG(5), PITX2(5), PPP1R13B(4), RACGAP1(2), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), SAG(3), WASF1(6), WASL(4)	93612265	198	120	196	68	36	49	31	41	40	1	0.915	1.000	1.000
346	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(1), ACADL(1), ACOX1(3), ACOX2(4), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ANGPTL4(1), APOA1(3), APOA5(3), CD36(4), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP27A1(1), CYP4A11(7), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(4), FABP1(2), FABP2(1), FABP3(1), FABP6(1), FABP7(1), FADS2(7), GK(5), GK2(4), HMGCS2(3), ILK(3), LPL(1), MMP1(2), NR1H3(2), OLR1(2), PCK1(5), PCK2(4), PDPK1(2), PLTP(3), PPARA(4), PPARD(2), PPARG(5), RXRA(2), RXRG(2), SCD(1), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A4(5), SLC27A5(4), SORBS1(7), UBC(12)	91519820	186	119	185	66	31	46	33	39	35	2	0.904	1.000	1.000
347	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(2), AKT2(4), AKT3(5), BCR(3), BTK(7), CD19(6), CDKN2A(1), DAPP1(2), FLOT1(2), FLOT2(2), GAB1(2), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), NR0B2(2), PDK1(2), PHF11(3), PITX2(5), PLCG2(8), PPP1R13B(4), PREX1(9), PTPRC(8), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SAG(3), SYK(4), TEC(6), VAV1(6)	74704039	172	118	170	39	36	42	24	41	29	0	0.0591	1.000	1.000
348	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AANAT(1), ACAT1(2), AFMID(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CARM1(4), CAT(2), CYP1A1(1), CYP1A2(2), CYP1B1(2), DDC(3), EHHADH(4), GCDH(2), HAAO(2), HADH(2), HADHA(2), HEMK1(2), HSD17B10(1), HSD17B4(8), INMT(4), KMO(7), KYNU(3), LCMT1(1), LCMT2(10), LNX1(6), MAOA(2), MAOB(4), METTL2B(4), NFX1(4), OGDH(7), OGDHL(6), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(2), TPH1(2), TPH2(3), WARS2(2), WBSCR22(2)	86508648	161	117	160	59	20	50	40	28	21	2	0.947	1.000	1.000
349	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(23), AXIN1(5), CCND1(1), CCND2(2), CCND3(4), CSNK1E(4), CTNNB1(2), DVL1(2), DVL3(1), FBXW2(4), FZD1(3), FZD10(2), FZD2(4), FZD3(5), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LDLR(4), MAPK10(4), MAPK9(1), MYC(1), PAFAH1B1(3), PPP2R5C(6), PPP2R5E(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(8), PRKCZ(2), PRKD1(5), RHOA(6), SFRP4(2), TCF7(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1)	80149103	173	117	172	56	38	39	27	32	33	4	0.832	1.000	1.000
350	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AGK(4), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AKR1A1(1), AKR1B1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), CEL(4), DAK(4), DGAT1(2), DGAT2(2), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(1), DGKZ(1), GK(5), GK2(4), GLA(5), GLB1(4), GPAM(6), LCT(17), LIPA(3), LIPC(2), LIPF(1), LIPG(3), LPL(1), PNLIP(5), PNLIPRP1(4), PNPLA3(3), PPAP2A(2), PPAP2C(1)	83773054	162	116	160	48	32	36	35	28	29	2	0.436	1.000	1.000
351	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(3), ATP6AP1(2), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CHUK(7), EGFR(5), F11R(4), GIT1(3), IGSF5(3), IKBKB(5), JUN(3), LYN(6), MAPK10(4), MAPK13(1), MAPK14(1), MAPK8(2), MAPK9(1), MET(10), NFKB1(5), NFKB2(5), NFKBIA(3), NOD1(6), PAK1(3), PLCG1(8), PLCG2(8), PTPN11(1), PTPRZ1(11), RELA(3), SRC(1), TCIRG1(2), TJP1(8)	100463456	168	116	166	55	33	49	26	22	38	0	0.829	1.000	1.000
352	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(4), AKT3(5), ASAH1(1), BRAF(5), DAG1(2), DRD2(3), EGFR(5), EPHB2(5), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(8), PITX2(5), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), RAF1(4), RGS20(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT3(5), TERF2IP(3)	83391667	173	116	171	42	30	46	18	47	32	0	0.154	1.000	1.000
353	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(6), AMY2A(4), AMY2B(1), ENPP1(7), ENPP3(5), G6PC(2), GAA(2), GANAB(10), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), MGAM(14), PGM1(5), PGM3(2), PYGB(4), PYGL(3), PYGM(5), RNPC3(2), SI(18), UCHL3(2), UGDH(1), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(5), UGT2B4(3), UXS1(3)	83062445	165	115	164	61	24	36	29	47	29	0	0.964	1.000	1.000
354	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(1), BTRC(4), CSNK1A1(3), CSNK1A1L(4), CSNK1E(4), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), GLI1(5), GLI2(12), GLI3(11), GSK3B(2), HHIP(1), IHH(2), LRP2(33), PRKACA(3), PRKACB(1), PRKACG(3), PRKX(5), PTCH1(11), PTCH2(2), SHH(1), SMO(5), STK36(1), SUFU(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1), ZIC2(1)	80696078	159	114	158	56	47	36	24	30	22	0	0.839	1.000	1.000
355	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPL(1), ALPP(3), ALPPL2(2), ASCC3(7), ATP13A2(3), DDX18(3), DDX23(4), DDX4(5), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(1), DDX54(2), DDX55(7), DDX56(2), DHX58(4), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(4), FPGS(4), GCH1(1), IFIH1(4), MOV10L1(6), NUDT5(1), NUDT8(1), QDPR(1), RAD54B(10), RAD54L(3), RUVBL2(1), SETX(18), SKIV2L2(4), SMARCA2(11), SMARCA5(5)	88749867	153	113	153	42	23	46	28	31	25	0	0.499	1.000	1.000
356	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(4), CHPT1(4), CRLS1(3), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(1), DGKZ(1), ESCO1(4), ESCO2(1), ETNK1(2), ETNK2(3), GNPAT(5), GPAM(6), GPD1(5), GPD2(3), LCAT(1), PCYT1A(2), PCYT1B(6), PEMT(1), PHOSPHO1(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLD1(7), PLD2(2), PNPLA3(3), PPAP2A(2), PPAP2C(1), PTDSS1(5), PTDSS2(3), SH3GLB1(2)	92770118	155	111	154	47	25	42	26	39	22	1	0.569	1.000	1.000
357	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	69	B2M(3), CALR(1), CANX(3), CD4(4), CD74(2), CD8A(3), CD8B(3), CIITA(5), CREB1(1), CTSB(2), CTSS(3), HLA-A(3), HLA-B(3), HLA-C(6), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-F(3), HLA-G(1), HSP90AA1(3), HSP90AB1(3), HSPA5(5), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), KIR2DL3(2), KIR3DL1(3), KIR3DL2(6), KIR3DL3(3), KLRC1(5), KLRC3(1), KLRD1(1), LGMN(2), LTA(2), NFYB(1), NFYC(3), RFX5(3), RFXANK(4), RFXAP(1), TAP1(2)	56506137	144	110	143	50	12	45	38	26	22	1	0.901	1.000	1.000
358	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(10), COL4A2(10), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), F10(5), F12(2), F2(2), F2R(4), F5(25), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(2), PROC(3), PROS1(4), SERPINC1(6), SERPING1(3)	64658603	149	109	149	38	22	34	39	27	27	0	0.331	1.000	1.000
359	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	53	ALG2(2), BAK1(3), BAX(3), BFAR(3), BTK(7), CAD(15), CASP10(2), CASP3(1), CD7(1), CSNK1A1(3), DAXX(2), DEDD(1), DEDD2(1), DFFA(4), DIABLO(1), EGFR(5), EPHB2(5), FAF1(7), IL1A(1), MAP2K7(1), MAP3K5(12), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MET(10), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NR0B2(2), PTPN13(16), RALBP1(3), RIPK1(5), ROCK1(8), SMPD1(2), TNFRSF6B(1), TPX2(2), TRAF2(1), TUFM(1)	89314427	173	109	170	46	33	50	26	30	33	1	0.457	1.000	1.000
360	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(4), AASS(5), ACAT1(2), AKR1B10(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), BBOX1(2), DLST(3), DOT1L(8), EHHADH(4), EHMT1(9), EHMT2(5), GCDH(2), HADH(2), HADHA(2), HSD17B10(1), HSD17B4(8), HSD3B7(1), NSD1(13), OGDH(7), OGDHL(6), PIPOX(2), PLOD1(2), PLOD2(2), PLOD3(5), RDH11(3), RDH12(2), RDH13(2), RDH14(2), SETD1A(4), SETD7(5), SETDB1(11), SHMT1(1), SHMT2(3), SPCS3(1), SUV39H1(2), SUV39H2(1), TMLHE(1)	79178595	149	108	147	54	23	38	32	32	24	0	0.927	1.000	1.000
361	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(5), CPEB1(7), EGFR(5), ERBB4(13), ETS1(3), ETS2(7), ETV6(4), ETV7(3), FMN2(17), MAP2K1(5), MAPK1(1), MAPK3(1), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), PIWIL2(5), PIWIL3(6), PIWIL4(4), RAF1(4), SOS1(5), SOS2(6), SPIRE1(2)	62473714	153	108	150	45	14	39	33	38	28	1	0.766	1.000	1.000
362	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(6), ACTB(5), ACTG1(8), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), LY96(1), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(2), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(4), WAS(7), WASL(4), YWHAZ(3)	70405203	158	108	154	54	27	48	23	32	28	0	0.907	1.000	1.000
363	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(6), ACTB(5), ACTG1(8), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), LY96(1), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(2), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(4), WAS(7), WASL(4), YWHAZ(3)	70405203	158	108	154	54	27	48	23	32	28	0	0.907	1.000	1.000
364	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(4), AGTR2(2), ATP8A1(4), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(4), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CX3CR1(2), CXCR3(6), CXCR4(3), CXCR6(1), EDNRA(3), EDNRB(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(1), GHSR(2), GNB2L1(2), GRPR(3), LHCGR(10), MC1R(1), MC2R(2), MC3R(3), MC4R(2), NMBR(3), NPY1R(5), NPY2R(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(3), OXTR(1), SSTR2(1), SSTR3(2), SSTR4(1), TACR1(2), TACR2(4), TACR3(2), TSHR(7)	71700849	158	108	158	53	30	39	25	48	15	1	0.409	1.000	1.000
365	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), CARM1(4), DBH(6), DCT(4), DDC(3), ECH1(1), ESCO1(4), ESCO2(1), FAH(2), GOT1(2), GOT2(1), GSTZ1(1), HEMK1(2), HGD(4), HPD(4), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), PNMT(1), PNPLA3(3), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(3), TH(2), TPO(7), TYR(5), TYRP1(7), WBSCR22(2)	82742512	154	107	151	40	26	37	38	24	27	2	0.402	1.000	1.000
366	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(2), AKT2(4), AKT3(5), BRAF(5), CAB39(1), DDIT4(1), EIF4B(2), FIGF(3), HIF1A(4), MAPK1(1), MAPK3(1), PDPK1(2), PGF(5), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRKAA1(3), PRKAA2(2), RHEB(1), RICTOR(7), RPS6(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), STK11(2), TSC1(5), TSC2(6), ULK1(4), ULK2(5), ULK3(4), VEGFA(1), VEGFC(2)	68339208	147	107	146	38	23	46	19	26	33	0	0.457	1.000	1.000
367	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(2), APC(23), AR(6), ASAH1(1), BRAF(5), CCL13(2), CCL15(1), DAG1(2), EGFR(5), GNA11(3), GNAI1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), MAPK10(4), MAPK14(1), PHKA2(13), PIK3CD(6), PITX2(5), PTX3(1), RAF1(4), SRC(1)	70670208	149	106	147	42	23	39	15	43	28	1	0.465	1.000	1.000
368	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(13), CARM1(4), CCND1(1), CREBBP(15), EP300(13), ERCC3(4), ESR1(5), GRIP1(6), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC1(6), HDAC2(2), HDAC3(1), HDAC4(5), HDAC5(6), HDAC6(16), MEF2C(4), NCOR2(8), NRIP1(10), PELP1(6), POLR2A(6), TBP(2)	66601673	138	104	137	47	18	33	27	26	34	0	0.952	1.000	1.000
369	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(4), CD28(2), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(5), GRAP2(2), ITK(7), ITPKA(1), ITPKB(8), LAT(1), LCK(2), LCP2(2), MAPK1(1), NCK1(2), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PLCG1(8), PTPRC(8), RAF1(4), RASGRP2(5), RASGRP3(2), RASGRP4(5), SOS1(5), SOS2(6), VAV1(6), ZAP70(3)	75728837	137	104	137	58	25	35	20	32	25	0	0.996	1.000	1.000
370	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(2), BDKRB2(4), CALM2(1), CAV1(4), CHRM1(4), CHRNA1(4), FLT1(5), FLT4(3), KDR(8), NOS3(3), PDE2A(4), PDE3A(12), PDE3B(4), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKG1(4), PRKG2(7), RYR2(53), SYT1(1)	58928406	138	103	137	65	19	42	26	30	19	2	0.999	1.000	1.000
371	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	45	ACOX1(3), APOA1(3), CD36(4), CITED2(2), CPT1B(4), CREBBP(15), DUSP1(1), DUT(1), EHHADH(4), EP300(13), FABP1(2), HSD17B4(8), JUN(3), LPL(1), MAPK1(1), MAPK3(1), MRPL11(1), MYC(1), NCOA1(5), NCOR2(8), NFKBIA(3), NR0B2(2), NR1H3(2), NR2F1(1), NRIP1(10), PPARA(4), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PTGS2(6), RELA(3), RXRA(2), SP1(6), STAT5A(6), STAT5B(5)	72960354	147	103	147	39	26	33	22	26	39	1	0.494	1.000	1.000
372	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1C1(5), AKR1C2(3), AKR1C3(1), AKR1C4(3), ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), CYP1A1(1), CYP1A2(2), CYP1B1(2), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2F1(5), CYP2S1(6), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHDH(1), EPHX1(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), MGST3(2), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3)	81732469	157	102	155	55	15	45	32	44	21	0	0.844	1.000	1.000
373	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(1), ACSS2(2), ACYP1(2), ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), G6PC2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(2), LDHC(4), PDHA1(3), PDHA2(4), PDHB(1), PFKL(1), PFKM(8), PFKP(6), PGAM2(1), PGAM4(2), PGK1(7), PGK2(1), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	82063278	140	101	137	33	18	36	32	27	27	0	0.0866	1.000	1.000
374	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(8), ACTG2(4), ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), CFL1(1), CFL2(1), FLNA(17), FLNC(21), FSCN1(1), FSCN3(1), GDI1(4), GDI2(2), LIMK1(7), MYH2(10), MYLK(11), MYLK2(5), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), WASF1(6), WASL(4)	65487837	152	101	151	52	31	30	27	29	34	1	0.896	1.000	1.000
375	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(2), CAD(15), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(1), DUT(1), ENTPD1(4), ITPA(1), NT5E(4), NUDT2(1), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(2), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), RRM1(4), RRM2(1), TK1(1), TK2(1), TXNRD1(6), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(2), UPP1(3)	81059720	132	100	130	53	21	37	19	27	27	1	0.990	1.000	1.000
376	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	36	AKT1(2), AKT2(4), AKT3(5), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), DAG1(2), EPHB2(5), ITPKA(1), ITPKB(8), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PI3(1), PIK3CD(6), PLCG2(8), PPP1R13B(4), RAF1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6)	66895083	132	100	132	34	26	35	20	29	22	0	0.276	1.000	1.000
377	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(3), AKR1D1(1), ARSE(4), CARM1(4), CYP11B1(5), CYP11B2(4), HEMK1(2), HSD11B1(3), HSD11B2(2), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD3B1(3), HSD3B2(4), LCMT1(1), LCMT2(10), METTL2B(4), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), SRD5A1(4), STS(1), SULT1E1(3), SULT2B1(2), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), WBSCR22(2)	69316391	135	99	134	49	12	44	31	27	20	1	0.912	1.000	1.000
378	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(23), ATR(13), BRCA1(13), BRCA2(14), CHEK1(2), CHEK2(5), FANCA(8), FANCC(4), FANCD2(9), FANCE(2), FANCF(2), FANCG(4), HUS1(1), MRE11A(7), RAD1(1), RAD17(3), RAD50(6), RAD51(2), RAD9A(1)	62527157	120	97	119	24	12	50	10	21	27	0	0.368	1.000	1.000
379	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F12(2), F13B(5), F2(2), F5(25), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), LPA(16), PLAT(6), PLG(7), SERPINB2(1), SERPINE1(5), SERPINF2(2), VWF(11)	50018893	125	96	123	35	19	24	33	25	24	0	0.485	1.000	1.000
380	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	CHUK(7), DAXX(2), EGF(5), EGFR(5), ETS1(3), ETS2(7), HRAS(2), IKBKB(5), JUN(3), MAP2K1(5), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K5(12), MAPK1(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(5), NFKBIA(3), PPP2CA(3), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(8), RAF1(4), RELA(3), RIPK1(5), SP1(6), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	63850286	134	96	131	38	29	32	18	29	25	1	0.575	1.000	1.000
381	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(3), AGT(3), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CAMK1G(5), CAMK4(5), CREBBP(15), CSNK1A1(3), EDN1(5), F2(2), GATA4(2), GSK3B(2), HAND2(3), HRAS(2), LIF(1), MAP2K1(5), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(4), MYH2(10), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NKX2-5(1), NPPA(1), PPP3CA(5), PPP3CB(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RAF1(4), RPS6KB1(4), SYT1(1)	65465610	132	96	132	49	20	39	25	28	19	1	0.922	1.000	1.000
382	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(8), ATP4B(3), ATP5A1(3), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), ATP5L(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(7), COX15(3), COX17(1), COX4I2(2), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(1), COX7B2(3), NDUFA1(2), NDUFA10(1), NDUFA2(1), NDUFA4(1), NDUFA4L2(1), NDUFA6(1), NDUFA7(1), NDUFA9(2), NDUFB1(2), NDUFB10(1), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB8(1), NDUFB9(3), NDUFS1(1), NDUFS2(7), NDUFS3(1), NDUFS5(1), NDUFS7(2), NDUFS8(1), NDUFV1(5), NDUFV2(1), NDUFV3(1), PPA1(4), PPA2(2), SDHB(2), TCIRG1(2), UQCRB(1), UQCRC1(1), UQCRC2(4), UQCRFS1(1)	80724127	153	95	153	45	26	45	26	29	27	0	0.485	1.000	1.000
383	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(2), ARHGAP4(4), ARHGAP5(12), ARHGAP6(5), ARHGEF1(10), ARHGEF11(6), ARHGEF5(10), ARPC1A(3), ARPC1B(2), ARPC2(5), BAIAP2(2), CFL1(1), DIAPH1(5), GSN(2), LIMK1(7), MYLK(11), OPHN1(4), PIP5K1A(6), PIP5K1B(2), PPP1R12B(4), ROCK1(8), SRC(1), TLN1(15), VCL(6)	65907665	137	95	134	54	20	33	22	21	41	0	0.991	1.000	1.000
384	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	AKT1(2), ASAH1(1), ATF1(3), BRAF(5), CREB1(1), CREB5(5), CREBBP(15), CRKL(1), DAG1(2), EGR1(3), EGR2(3), EGR3(4), ELK1(4), FRS2(1), GNAQ(1), JUN(3), MAP1B(8), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NTRK1(8), OPN1LW(3), PIK3C2G(8), PIK3CD(6), PTPN11(1), RPS6KA3(8), SHC1(2), SRC(1), TERF2IP(3), TH(2)	65109636	125	95	123	33	33	27	15	22	28	0	0.379	1.000	1.000
385	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(2), LDHC(4), PDHA1(3), PDHA2(4), PDHB(1), PFKM(8), PFKP(6), PGK1(7), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	68900192	126	94	123	30	18	30	29	22	27	0	0.125	1.000	1.000
386	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(2), LDHC(4), PDHA1(3), PDHA2(4), PDHB(1), PFKM(8), PFKP(6), PGK1(7), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	68900192	126	94	123	30	18	30	29	22	27	0	0.125	1.000	1.000
387	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(8), AARS2(5), CARS(4), CARS2(5), DARS(3), DARS2(2), EARS2(3), EPRS(11), FARS2(4), FARSA(3), FARSB(5), GARS(2), HARS(2), IARS(8), IARS2(5), LARS(5), LARS2(3), MARS(9), MARS2(1), NARS(1), NARS2(2), PARS2(2), QARS(10), RARS(5), RARS2(3), SARS(4), SARS2(2), TARS(8), TARS2(9), VARS(2), VARS2(1), WARS2(2), YARS(4), YARS2(1)	74385289	144	94	142	39	18	52	19	30	25	0	0.500	1.000	1.000
388	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(5), ACTN2(10), BCAR1(6), BCR(3), CAPN1(8), CAV1(4), CRKL(1), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(4), PTK2(7), RAF1(4), RAP1A(2), ROCK1(8), SHC1(2), SOS1(5), SRC(1), TLN1(15), VCL(6), ZYX(1)	66725288	122	94	122	41	26	29	15	25	25	2	0.845	1.000	1.000
389	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(2), AKT2(4), AKT3(5), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(13), PIK3CB(8), PITX2(5), PLD1(7), PLD2(2), PLD3(2), VN1R1(1)	63239153	132	94	131	35	22	39	12	34	25	0	0.289	1.000	1.000
390	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(4), CLC(1), CPT1B(4), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKQ(1), DGKZ(1), ETNK1(2), GNPAT(5), GPD1(5), GPD2(3), LCAT(1), LGALS13(3), PAFAH1B1(3), PCYT1A(2), PCYT1B(6), PEMT(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCB2(7), PLCG1(8), PLCG2(8), PPAP2A(2), PPAP2C(1)	70156202	130	93	129	42	22	34	20	30	23	1	0.693	1.000	1.000
391	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(8), AR(6), ESR1(5), ESR2(4), HNF4A(2), NR1D1(5), NR1D2(2), NR1H2(7), NR1H3(2), NR1I2(2), NR1I3(2), NR2C2(1), NR2E1(3), NR2F1(1), NR2F2(1), NR3C1(3), NR4A1(2), NR4A2(3), NR5A1(1), NR5A2(7), PGR(6), PPARA(4), PPARD(2), PPARG(5), RARA(1), RARB(6), RARG(3), ROR1(9), RORA(1), RORC(2), RXRA(2), RXRG(2), THRA(3), THRB(2)	56536967	115	93	114	42	28	18	19	21	29	0	0.914	1.000	1.000
392	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AGPAT1(1), AGPAT3(2), AGPAT4(2), AKR1A1(1), AKR1B1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), CEL(4), DGAT1(2), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKQ(1), DGKZ(1), GK(5), GLA(5), GLB1(4), LCT(17), LIPC(2), LIPF(1), LIPG(3), LPL(1), PNLIP(5), PNLIPRP1(4), PPAP2A(2), PPAP2C(1)	68535641	126	92	124	43	26	26	26	21	26	1	0.759	1.000	1.000
393	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), DAG1(2), DGKA(2), ITGA9(7), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAPK1(1), MAPK3(1), NR1I3(2), PAK1(3), PDE3A(12), PDE3B(4), PI3(1), PIK3C2G(8), PIK3CD(6), RIPK3(4), RPS4X(2), SGCB(2)	64897989	125	92	123	40	19	38	13	33	22	0	0.750	1.000	1.000
394	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP51A1(2), DDC(3), EHHADH(4), GCDH(2), HAAO(2), HADHA(2), KMO(7), KYNU(3), MAOA(2), MAOB(4), TDO2(2), TPH1(2), WARS2(2)	79049771	136	92	135	54	14	38	24	36	23	1	0.970	1.000	1.000
395	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACADVL(4), ACAT1(2), ACOX1(3), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP4A11(7), CYP4A22(2), EHHADH(4), GCDH(2), HADH(2), HADHA(2), HADHB(3), HSD17B10(1), HSD17B4(8)	70280258	126	91	125	36	21	32	30	27	15	1	0.418	1.000	1.000
396	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(2), AKT2(4), AKT3(5), BRD4(3), CAP1(2), CBL(4), CDKN2A(1), F2RL2(2), FLOT1(2), FLOT2(2), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(8), PARD6A(1), PDK1(2), PIK3CD(6), RAF1(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SERPINB6(2), SFN(1), SHC1(2), SLC2A4(1), SORBS1(7), SOS1(5), SOS2(6), YWHAB(2), YWHAG(1), YWHAZ(3)	73607589	129	90	128	44	26	39	11	27	25	1	0.863	1.000	1.000
397	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(5), ABAT(7), ACADS(2), ACAT1(2), ACSM1(2), AKR1B10(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH5A1(2), ALDH9A1(1), BDH1(1), DDHD1(4), EHHADH(4), GAD1(3), GAD2(3), HADH(2), HADHA(2), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), HSD3B7(1), ILVBL(5), L2HGDH(2), OXCT1(5), OXCT2(5), PDHA1(3), PDHA2(4), PDHB(1), PLA1A(3), PPME1(2), RDH11(3), RDH12(2), RDH13(2), RDH14(2)	58240062	117	89	114	30	19	29	21	28	20	0	0.251	1.000	1.000
398	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	32	AKT1(2), AKT2(4), AKT3(5), ARHGEF11(6), DLG4(1), GNA13(1), LPA(16), MAP3K5(12), MAPK8(2), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(13), PI3(1), PIK3CB(8), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RDX(3), ROCK1(8), ROCK2(9), SERPINA4(4), SRF(1)	64362666	132	89	131	37	29	38	15	21	29	0	0.488	1.000	1.000
399	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	35	AKT1(2), ATF2(4), DLD(1), DUSP10(9), DUSP4(1), GAB1(2), GCK(3), IL1R1(1), JUN(3), MAP2K5(1), MAP2K7(1), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAP3K9(5), MAPK10(4), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(7), NR2C2(1), PAPPA(13), SHC1(2), TRAF6(4), ZAK(4)	64341720	125	89	123	29	21	28	14	25	37	0	0.329	1.000	1.000
400	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(4), AKT3(5), ANKRD6(5), APC(23), AXIN1(5), AXIN2(5), CER1(2), CSNK1A1(3), CTNNB1(2), DACT1(2), DKK2(1), DKK3(4), DKK4(4), DVL1(2), FSTL1(1), GSK3A(5), GSK3B(2), LRP1(27), MVP(1), NKD1(1), NKD2(2), PSEN1(2), PTPRA(6), SENP2(1), SFRP1(3), WIF1(3)	56840163	123	89	123	37	23	33	15	25	24	3	0.745	1.000	1.000
401	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(2), CDK2(2), CDT1(1), DIAPH2(9), GMNN(2), MCM10(7), MCM2(3), MCM3(3), MCM4(5), MCM5(3), MCM6(4), MCM7(7), NACA(8), POLA2(5), POLD1(5), POLD2(1), POLE(10), POLE2(2), PRIM1(1), RFC1(7), RFC4(3), RFC5(1), RPA1(1), RPA2(1), RPA3(2), RPA4(3), UBA52(2), UBC(12)	72275642	116	87	115	40	14	40	15	25	21	1	0.960	1.000	1.000
402	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(23), ASAH1(1), DAG1(2), DLG4(1), EPHB2(5), GNAI1(2), GNAQ(1), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PITX2(5), PTX3(1), RHO(2), RYR1(30)	65570823	127	87	126	46	25	28	16	38	19	1	0.888	1.000	1.000
403	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(1), B4GALT1(3), G6PC(2), G6PC2(3), GAA(2), GALK2(3), GALT(1), GANC(4), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), HSD3B7(1), LALBA(1), LCT(17), MGAM(14), PFKL(1), PFKM(8), PFKP(6), PGM1(5), PGM3(2), RDH11(3), RDH12(2), RDH13(2), RDH14(2), UGP2(4)	54230601	114	86	111	32	12	21	23	35	23	0	0.407	1.000	1.000
404	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(7), ACAA1(1), ACAA2(2), ACADS(2), ACAT1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH6A1(1), ALDH9A1(1), AOX1(7), AUH(1), BCAT1(4), BCAT2(5), BCKDHA(4), BCKDHB(1), DBT(1), DLD(1), EHHADH(4), HADH(2), HADHA(2), HADHB(3), HIBADH(2), HIBCH(2), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), OXCT2(5), PCCA(4), PCCB(2)	62262318	114	86	111	29	20	31	18	24	21	0	0.358	1.000	1.000
405	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BTK(7), CALM2(1), ELK1(4), FCER1A(4), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP2K7(1), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), PAK2(2), PLA2G4A(7), PLCG1(8), PPP3CA(5), PPP3CB(2), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(1), VAV1(6)	49334837	105	85	105	30	21	30	16	22	16	0	0.496	1.000	1.000
406	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CALM2(1), CD3E(3), CD3G(3), ELK1(4), HRAS(2), JUN(3), LAT(1), LCK(2), MAP2K1(5), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB1(5), NFKBIA(3), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKCA(4), PTPN7(2), RAF1(4), RASA1(2), RELA(3), SHC1(2), SOS1(5), SYT1(1), VAV1(6), ZAP70(3)	56444855	104	85	104	41	22	27	15	21	19	0	0.948	1.000	1.000
407	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(12), EEF1A2(3), EEF1B2(2), EEF1D(1), EEF1G(1), EEF2(5), EEF2K(6), EIF1AX(3), EIF2AK1(5), EIF2AK2(3), EIF2AK3(4), EIF2B1(2), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G3(5), EIF5(2), EIF5B(5), ETF1(3), GSPT2(5), PABPC1(2), PABPC3(8)	63092641	117	85	116	30	21	41	16	16	23	0	0.483	1.000	1.000
408	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(4), AKT3(5), CISH(2), IARS(8), IL13RA1(1), IL2RG(2), IL4(1), IL4R(6), INPP5D(4), JAK1(11), JAK2(7), JAK3(8), NR0B2(2), PI3(1), PPP1R13B(4), RPS6KB1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT6(7), TYK2(7)	48938796	104	84	102	26	16	23	19	17	28	1	0.393	1.000	1.000
409	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH4A1(3), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), GAMT(1), GATM(3), GLUD1(2), GOT1(2), GOT2(1), MAOA(2), MAOB(4), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(4), P4HA3(3), P4HB(2), RARS(5)	62290750	122	83	121	35	20	29	38	20	15	0	0.381	1.000	1.000
410	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(1), ALOX12(7), ALOX12B(1), ALOX15(4), ALOX15B(5), ALOX5(3), CBR1(3), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2U1(1), CYP4A11(7), CYP4A22(2), CYP4F2(3), CYP4F3(2), DHRS4(1), EPHX2(2), GGT1(4), GPX2(1), GPX5(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PTGDS(2), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(6), TBXAS1(3)	55464863	112	83	112	29	16	30	27	23	16	0	0.156	1.000	1.000
411	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(8), ACTG2(4), ADCY3(5), ADCY9(14), AK1(1), ARF1(2), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(3), GNAS(11), PDIA4(7), PLCG1(8), PLCG2(8), PRKCA(4), SEC61A1(4), SEC61A2(3), TRIM23(4)	53014253	122	83	121	31	23	35	19	19	26	0	0.274	1.000	1.000
412	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(2), CALM2(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CDK5(2), F2(2), GNA11(3), GNAI1(2), GNB1(2), HRAS(2), JAK2(7), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(3), MYLK(11), PLCG1(8), PRKCA(4), PTK2B(6), RAF1(4), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), SYT1(1)	59913509	108	82	108	36	18	30	16	22	22	0	0.760	1.000	1.000
413	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(1), CAMK1(1), CAMK1G(5), ELK1(4), FPR1(3), GNB1(2), HRAS(2), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK1(1), MAPK14(1), MAPK3(1), NCF1(1), NCF2(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB1(5), NFKBIA(3), PAK1(3), PIK3C2G(8), PLCB1(12), PPP3CA(5), PPP3CB(2), RAF1(4), RELA(3), SYT1(1)	50391653	108	82	107	30	17	33	18	23	17	0	0.442	1.000	1.000
414	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(2), AKR1B10(1), ALAS1(5), ALAS2(7), AMT(1), AOC2(6), AOC3(3), BHMT(1), CBS(1), CHKA(1), CHKB(4), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(3), GLDC(8), HSD3B7(1), MAOA(2), MAOB(4), PEMT(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(1), RDH11(3), RDH12(2), RDH13(2), RDH14(2), SARDH(5), SARS(4), SARS2(2), SHMT1(1), SHMT2(3), TARS(8), TARS2(9)	61084948	116	82	116	41	12	28	21	35	20	0	0.825	1.000	1.000
415	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	ARSB(3), FUCA1(1), FUCA2(3), GALNS(2), GBA(2), GLB1(4), GNS(2), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(2), IDUA(1), LCT(17), MAN2B1(6), MAN2B2(6), MAN2C1(6), MANBA(5), NAGLU(1), NEU1(1), NEU3(2), SPAM1(4)	46846410	100	82	101	33	16	30	16	20	18	0	0.709	1.000	1.000
416	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(2), ALAS1(5), ALAS2(7), AMT(1), AOC2(6), AOC3(3), ATP6V0C(1), BHMT(1), CBS(1), CHKA(1), CHKB(4), CPT1B(4), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(3), GLDC(8), MAOA(2), MAOB(4), PEMT(1), PLCB2(7), PLCG1(8), PLCG2(8), PSPH(1), SARDH(5), SARS(4), SHMT1(1), SHMT2(3), TARS(8)	59912989	118	81	118	45	18	24	20	32	23	1	0.938	1.000	1.000
417	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFAT5(7), PDE6A(7), PDE6B(3), PDE6C(7), SLC6A13(3), TF(5)	51487665	101	81	100	34	14	30	15	27	15	0	0.789	1.000	1.000
418	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(7), CALM2(1), CD79B(2), ELK1(4), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAPK14(1), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKCA(4), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(1), VAV1(6)	49272121	98	80	98	36	19	25	16	23	15	0	0.895	1.000	1.000
419	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CALM2(1), CREB1(1), ELK1(4), GNAI1(2), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), JUN(3), MAP2K1(5), MAPK3(1), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), RAF1(4), RPS6KA3(8), SYT1(1)	47348095	104	80	104	38	26	27	14	18	19	0	0.905	1.000	1.000
420	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ACY3(3), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), AMDHD1(4), AOC2(6), AOC3(3), ASPA(4), CARM1(4), CNDP1(7), DDC(3), HAL(7), HARS(2), HEMK1(2), HNMT(2), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), PRPS2(1), UROC1(4), WBSCR22(2)	54757353	113	80	112	27	18	30	26	13	25	1	0.201	1.000	1.000
421	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(3), ALG10B(5), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG5(5), ALG6(2), ALG8(1), ALG9(2), B4GALT1(3), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(3), DOLPP1(2), DPAGT1(3), DPM1(4), FUT8(3), GANAB(10), MAN1A1(6), MAN1A2(2), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(3), MGAT4B(4), MGAT5(3), MGAT5B(8), RPN1(4), RPN2(2), ST6GAL1(3), STT3B(3)	59309899	117	79	117	35	12	31	28	23	22	1	0.632	1.000	1.000
422	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(3), CRK(1), CRKL(1), DOCK1(8), ELK1(4), GAB1(2), HGF(5), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAP4K1(6), MAPK1(1), MAPK3(1), MAPK8(2), MET(10), PAK1(3), PTK2(7), PTK2B(6), PTPN11(1), RAF1(4), RAP1A(2), RAP1B(1), RASA1(2), SOS1(5), SRC(1), STAT3(5)	58690989	104	79	104	35	23	29	18	18	15	1	0.817	1.000	1.000
423	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(5), ALAS2(7), BLVRA(4), BLVRB(1), COX10(7), COX15(3), CP(7), EARS2(3), EPRS(11), FTMT(2), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), MMAB(1), PPOX(5), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UROD(2), UROS(2)	59796273	118	78	117	42	9	36	20	35	17	1	0.936	1.000	1.000
424	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(8), CAPN2(8), CXCR3(6), EGF(5), EGFR(5), HRAS(2), ITGA1(6), ITGB1(5), MAPK1(1), MAPK3(1), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PTK2(7), TLN1(15)	47804254	95	77	94	34	19	23	21	17	14	1	0.824	1.000	1.000
425	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(3), G6PC(2), GAA(2), GALK2(3), GALT(1), GANAB(10), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), LALBA(1), LCT(17), MGAM(14), PFKM(8), PFKP(6), PGM1(5), PGM3(2)	46025028	101	76	98	28	13	18	22	28	20	0	0.402	1.000	1.000
426	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(12), ACACB(10), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), ACYP1(2), AKR1B1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(2), LDHA(2), LDHC(4), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PCK2(4), PDHA1(3), PDHA2(4), PDHB(1), PKLR(5)	66013581	97	76	96	33	21	24	20	18	14	0	0.697	1.000	1.000
427	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(1), B3GALNT1(1), B3GALT1(3), B3GALT2(2), B3GALT4(2), B3GALT5(2), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT6(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GBGT1(2), GCNT2(1), PIGA(5), PIGB(2), PIGG(6), PIGL(1), PIGM(3), PIGN(4), PIGO(3), PIGQ(3), PIGS(2), PIGT(4), PIGV(2), PIGZ(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(4), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(1), ST8SIA1(1), UGCG(1)	67007294	101	76	101	33	14	27	27	21	12	0	0.615	1.000	1.000
428	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(5), ELK1(4), GNAS(11), GNB1(2), HRAS(2), IGF1R(7), ITGB1(5), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MYC(1), NGFR(1), PDGFRA(6), PPP2CA(3), PTPRR(4), RAF1(4), RPS6KA1(6), RPS6KA5(4), SHC1(2), SOS1(5), SRC(1), STAT3(5)	46623727	96	75	94	24	19	26	11	26	14	0	0.332	1.000	1.000
429	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(9), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(4), BTRC(4), CDC16(3), CDC20(1), CDC23(1), CUL1(2), CUL2(4), CUL3(4), ITCH(4), SKP1(1), SKP2(2), SMURF1(3), SMURF2(5), TCEB1(1), UBA1(8), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), WWP1(6), WWP2(12)	53409462	93	74	90	26	13	35	15	17	12	1	0.681	1.000	1.000
430	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), CHUK(7), ELK1(4), IKBKB(5), IRAK1(3), JUN(3), LY96(1), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(1), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), PPARA(4), RELA(3), TIRAP(1), TLR10(3), TLR2(3), TLR3(7), TLR4(15), TLR7(9), TLR9(2), TRAF6(4)	46790168	94	74	93	24	15	29	16	15	19	0	0.345	1.000	1.000
431	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(23), ATF2(4), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(4), BMPR1A(1), BMPR2(8), CHRD(5), CTNNB1(2), DVL1(2), FZD1(3), GATA4(2), GSK3B(2), MAP3K7(3), MEF2C(4), NKX2-5(1), NOG(1), NPPA(1), RFC1(7), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4)	50609216	100	72	99	30	13	26	13	28	18	2	0.746	1.000	1.000
432	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(3), ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(13), ATP7B(6), COX10(7), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(1), NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(3), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1), PPA2(2), SDHB(2), SHMT1(1), UQCRB(1), UQCRC1(1), UQCRFS1(1)	55743348	106	72	106	37	21	33	15	20	17	0	0.822	1.000	1.000
433	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(2), ARSE(4), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(4), DEGS2(1), ENPP7(5), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS1(2), SGMS2(2), SGPP1(2), SGPP2(1), SMPD1(2), SMPD3(1), SMPD4(2), SPHK1(1), SPHK2(2), SPTLC1(4), SPTLC2(6), UGCG(1), UGT8(5)	47142244	92	71	90	26	18	26	14	22	12	0	0.419	1.000	1.000
434	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	23	AKT1(2), AKT2(4), AKT3(5), BAD(1), GSK3A(5), GSK3B(2), IL4R(6), IRS1(4), JAK1(11), JAK3(8), MAP4K1(6), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(6), PPP1R13B(4), RAF1(4), SHC1(2), SOS1(5), SOS2(6), STAT6(7)	43588393	92	71	92	24	14	21	16	20	21	0	0.391	1.000	1.000
435	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(1), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), FUK(4), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), HSD3B7(1), KHK(4), MPI(2), MTMR1(1), MTMR2(2), MTMR6(3), PFKFB2(1), PFKFB3(4), PFKFB4(3), PFKL(1), PFKM(8), PFKP(6), PGM2(5), PMM1(2), RDH11(3), RDH12(2), RDH13(2), RDH14(2), SORD(2), TPI1(2), TSTA3(2)	53080385	94	69	92	31	14	19	14	25	22	0	0.734	1.000	1.000
436	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(6), AASDHPPT(4), AASS(5), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), ATP6V0C(1), BBOX1(2), DLST(3), DOT1L(8), EHHADH(4), EHMT1(9), EHMT2(5), GCDH(2), HADHA(2), PLOD1(2), PLOD2(2), PLOD3(5), SHMT1(1), SHMT2(3), TMLHE(1)	49170055	87	69	86	40	10	19	21	18	19	0	0.995	1.000	1.000
437	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(4), C1GALT1(3), C1GALT1C1(3), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(4), GALNT8(5), GALNT9(5), GALNTL5(7), GCNT3(1), GCNT4(3), OGT(5), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(5), WBSCR17(7)	46750268	93	68	93	37	15	23	14	26	13	2	0.959	1.000	1.000
438	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A1L(2), GTF2E1(2), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H3(2), GTF2I(4), GTF2IRD1(1), STON1(5), TAF1(14), TAF13(1), TAF1L(19), TAF2(6), TAF4(3), TAF4B(6), TAF5(4), TAF5L(5), TAF6(3), TAF6L(2), TAF7(1), TAF7L(6), TAF9(1), TBPL2(2)	50925521	98	68	97	23	18	31	15	17	17	0	0.296	1.000	1.000
439	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(15), POLA2(5), POLB(1), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLG(7), POLG2(2), POLH(3), POLI(2), POLK(2), POLL(2), POLM(3), POLQ(12), PRIM1(1), REV1(6), REV3L(17), RFC5(1)	58375671	98	68	96	26	10	23	21	24	19	1	0.650	1.000	1.000
440	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(12), DIAPH1(5), GSN(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), MYLK(11), PTK2(7), RAF1(4), ROCK1(8), SHC1(2), SRC(1), TLN1(15)	49093717	87	67	87	26	14	24	15	15	19	0	0.677	1.000	1.000
441	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(12), ACAT1(2), ACYP1(2), ADH5(5), AKR1B1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(2), LDHA(2), LDHC(4), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PDHA1(3), PDHA2(4), PDHB(1), PKLR(5)	52005884	89	67	88	28	16	25	18	15	15	0	0.600	1.000	1.000
442	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(2), ATF1(3), CREB1(1), CREB5(5), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(4), IL1R1(1), MAP2K3(3), MAP2K6(1), MAP3K10(3), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAPK1(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(2), MKNK2(4), MYEF2(3), NFKB1(5), NR2C2(1), SRF(1), TRAF6(4)	46222859	86	67	84	35	14	20	11	22	19	0	0.972	1.000	1.000
443	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(2), AZIN1(3), CBX3(1), CLOCK(3), CRY1(2), CRY2(3), DNAJA1(2), EIF4G2(2), ETV6(4), GSTP1(1), HSPA8(6), IDI1(5), MYF6(5), NCKAP1(9), NR1D2(2), PER1(9), PER2(8), PPP1R3C(3), PPP2CB(2), SF3A3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(4), VAPA(2), ZFR(7)	51630583	92	66	92	32	13	37	15	12	14	1	0.945	1.000	1.000
444	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(3), EGF(5), EGFR(5), ELK1(4), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6)	43247897	82	65	81	24	15	17	11	21	18	0	0.632	1.000	1.000
445	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(3), DDX20(4), E2F1(5), E2F4(2), ETS1(3), ETS2(7), ETV3(4), HDAC2(2), HDAC5(6), HRAS(2), JUN(3), NCOR2(8), RBL1(6), SIN3A(10), SIN3B(7)	37499800	77	65	77	21	14	21	8	13	21	0	0.663	1.000	1.000
446	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(1), ARRB2(1), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CLCA1(6), CLCA2(5), CLCA4(4), CNGA3(4), CNGA4(5), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(5), PRKACA(3), PRKACB(1), PRKACG(3), PRKG1(4), PRKG2(7), PRKX(5)	44151063	83	65	82	41	12	21	15	22	13	0	0.997	1.000	1.000
447	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(6), AP2M1(1), ARF1(2), BAD(1), BTK(7), EEA1(10), GRASP(2), GSK3A(5), GSK3B(2), LYN(6), PDPK1(2), PFKL(1), PFKM(8), PFKP(6), PLCG1(8), PRKCE(8), PRKCZ(2), RPS6KB1(4), VAV2(3)	35611850	86	65	84	31	17	19	12	19	19	0	0.907	1.000	1.000
448	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(5), ACTN2(10), CAPN1(8), ITGA1(6), ITGB1(5), ITGB3(4), PTK2(7), SPTAN1(12), SRC(1), TLN1(15)	41420721	76	65	76	25	17	16	12	16	14	1	0.793	1.000	1.000
449	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(1), ACAA2(2), ACAD8(1), ACAD9(4), ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1B10(1), AKR1C4(3), AKR1D1(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), HSD3B7(1), LIPA(3), RDH11(3), RDH12(2), RDH13(2), RDH14(2), SLC27A5(4), SOAT1(2), SOAT2(2), SRD5A1(4)	44833176	83	64	82	28	13	15	23	14	18	0	0.698	1.000	1.000
450	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	AKT1(2), BAD(1), BCL2L1(1), CBL(4), CFLAR(1), CRKL(1), E2F1(5), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), IRS1(4), JAK1(11), JAK3(8), MAPK1(1), MAPK3(1), MYC(1), NMI(2), RAF1(4), RPS6KB1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4)	44336565	82	64	82	21	15	20	13	18	16	0	0.354	1.000	1.000
451	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(23), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), EP300(13), FZD1(3), GSK3B(2), HDAC1(6), LDB1(1), PITX2(5), TRRAP(12)	46576853	89	64	89	32	13	17	14	25	18	2	0.933	1.000	1.000
452	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	31	AGT(3), AGTR1(4), ATF2(4), CALM2(1), EGFR(5), ELK1(4), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(6), MEF2C(4), MEF2D(3), PAK1(3), PRKCA(4), PTK2(7), PTK2B(6), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(1)	44015056	84	63	83	22	14	26	11	19	14	0	0.350	1.000	1.000
453	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GHR(5), HRAS(2), INSR(11), IRS1(4), JAK2(7), MAP2K1(5), MAPK1(1), MAPK3(1), PLCG1(8), PRKCA(4), RAF1(4), RPS6KA1(6), SHC1(2), SLC2A4(1), SOS1(5), SRF(1), STAT5A(6), STAT5B(5)	40965818	78	63	77	20	14	27	6	13	18	0	0.356	1.000	1.000
454	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(2), APC(23), AXIN1(5), CCND1(1), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(4), GNAI1(2), GSK3B(2), IRAK1(3), LBP(1), LY96(1), MYD88(1), NFKB1(5), PDPK1(2), PPP2CA(3), RELA(3), TIRAP(1), TLR4(15)	36424565	82	63	81	27	9	25	10	24	12	2	0.864	1.000	1.000
455	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(3), CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(7), MYLK(11), NCF2(7), PAK1(3), PDGFRA(6), PLD1(7), PPP1R12B(4), RALBP1(3), RPS6KB1(4), TRIO(13), VAV1(6), WASF1(6)	41249139	88	63	87	32	9	25	20	16	18	0	0.896	1.000	1.000
456	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(23), AXIN1(5), BTRC(4), CCND1(1), CREBBP(15), CSNK1A1(3), CSNK2A1(3), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(2), HDAC1(6), MAP3K7(3), MYC(1), NLK(1), PPARD(2), PPP2CA(3), TLE1(4), WIF1(3)	41401703	87	63	87	26	17	25	9	17	17	2	0.754	1.000	1.000
457	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(8), CARS(4), DARS(3), EPRS(11), FARS2(4), GARS(2), HARS(2), IARS(8), LARS(5), LARS2(3), MARS(9), MARS2(1), NARS(1), QARS(10), RARS(5), SARS(4), TARS(8), WARS2(2), YARS(4)	46252360	94	62	93	26	10	34	12	22	16	0	0.517	1.000	1.000
458	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(7), ACACA(12), ACACB(10), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(2), HIBCH(2), LDHA(2), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1)	57188767	79	62	78	33	8	23	16	19	13	0	0.965	1.000	1.000
459	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), NOS1(13), PPP3CA(5), PPP3CB(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), SYT1(1)	36138763	79	62	79	35	17	21	17	13	11	0	0.938	1.000	1.000
460	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	36	ATF2(4), CREB1(1), DAXX(2), ELK1(4), HMGN1(1), HRAS(2), MAP2K6(1), MAP3K5(12), MAP3K7(3), MAP3K9(5), MAPK14(1), MAPKAPK2(1), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MYC(1), PLA2G4A(7), RIPK1(5), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1)	47664274	86	62	85	23	16	28	9	22	11	0	0.417	1.000	1.000
461	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PTPRC(8), ZAP70(3)	30964507	78	61	78	29	15	18	17	13	15	0	0.906	1.000	1.000
462	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PTPRC(8), ZAP70(3)	30964507	78	61	78	29	15	18	17	13	15	0	0.906	1.000	1.000
463	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(3), ELK1(4), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PDGFRA(6), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6)	39555739	78	61	78	21	15	20	9	17	17	0	0.455	1.000	1.000
464	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH6A1(1), ALDH9A1(1), AOX1(7), BCAT1(4), BCKDHA(4), BCKDHB(1), EHHADH(4), HADHA(2), HADHB(3), HIBADH(2), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), PCCA(4), PCCB(2)	51915745	82	60	81	24	12	19	14	19	18	0	0.639	1.000	1.000
465	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	28	AKR1C4(3), AKR1D1(1), ARSB(3), ARSE(4), CYP11B1(5), CYP11B2(4), HSD11B1(3), HSD11B2(2), HSD17B2(4), HSD17B3(2), HSD3B1(3), HSD3B2(4), SRD5A1(4), STS(1), SULT1E1(3), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(5), UGT2B4(3)	38157768	77	59	76	26	7	23	19	19	9	0	0.646	1.000	1.000
466	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(7), IFNA1(1), IKBKB(5), IL1A(1), IL1R1(1), IL1RAP(10), IL1RN(2), IL6(1), IRAK1(3), IRAK2(4), IRAK3(2), JUN(3), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(1), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), TGFB1(2), TGFB2(1), TGFB3(1), TRAF6(4)	38357131	70	59	70	20	13	19	14	11	13	0	0.603	1.000	1.000
467	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(4), EIF2B1(2), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), ELAVL1(4), FLT1(5), FLT4(3), HIF1A(4), HRAS(2), KDR(8), NOS3(3), PLCG1(8), PRKCA(4), PTK2(7), SHC1(2)	42893898	75	58	75	25	12	26	13	12	11	1	0.768	1.000	1.000
468	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(5), AKT1(2), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CREB1(1), GNAS(11), HRAS(2), MAPK1(1), MAPK14(1), MAPK3(1), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), RPS6KA1(6), RPS6KA5(4), SOS1(5)	35301384	66	57	65	24	16	15	11	12	12	0	0.920	1.000	1.000
469	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), ACP5(3), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP51A1(2), PON1(4)	41449158	80	57	79	26	12	20	13	25	10	0	0.586	1.000	1.000
470	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(5), C6(8), C7(8), ICAM1(2), IL1A(1), IL6(1), ITGA4(6), ITGAL(4), ITGB1(5), ITGB2(7), SELP(10), SELPLG(2), VCAM1(7)	35595483	74	57	74	27	8	21	16	20	9	0	0.865	1.000	1.000
471	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), HRH1(4), HRH2(4), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(5), HTR5A(4)	35177144	76	57	76	33	25	11	11	20	9	0	0.773	1.000	1.000
472	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(7), ACACA(12), ACADL(1), ACADSB(4), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(2), LDHA(2), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1)	47786853	74	57	73	30	5	24	13	17	15	0	0.964	1.000	1.000
473	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(3), ERCC3(4), GTF2E1(2), GTF2E2(3), GTF2F2(1), GTF2H1(2), ILK(3), MNAT1(2), POLR1A(10), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLR3B(2), POLR3D(2), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(1), TAF5(4), TAF6(3), TAF7(1), TAF9(1), TBP(2)	49412064	76	57	75	31	10	19	12	16	19	0	0.982	1.000	1.000
474	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CALM2(1), CHUK(7), EGR2(3), EGR3(4), GNAQ(1), MYC(1), NFATC1(5), NFATC2(4), NFKB1(5), NFKBIA(3), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RELA(3), SYT1(1), VIP(1), VIPR2(3)	34333242	69	57	69	26	14	22	10	10	13	0	0.871	1.000	1.000
475	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(7), ACADL(1), ACADSB(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(2), MLYCD(4), UPB1(2)	41065561	71	56	70	26	7	19	17	14	14	0	0.867	1.000	1.000
476	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	26	AKT1(2), CABIN1(8), CALM2(1), CAMK1(1), CAMK1G(5), HDAC5(6), IGF1R(7), INSR(11), MAP2K6(1), MAPK14(1), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NFATC1(5), NFATC2(4), PPP3CA(5), PPP3CB(2), SYT1(1)	42362073	77	56	77	26	7	27	8	21	14	0	0.747	1.000	1.000
477	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(7), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(2), HIBCH(2), MLYCD(4), SRM(4), UPB1(2)	37895293	67	56	66	20	7	16	18	13	13	0	0.591	1.000	1.000
478	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(1), EPHB2(5), F2(2), F2RL1(1), F2RL2(2), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(4), MAPK8(2), MYEF2(3), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RAF1(4), RASAL1(5), SRC(1), TEC(6), VAV1(6)	39256202	72	56	72	20	20	19	11	12	10	0	0.369	1.000	1.000
479	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(7), ACADS(2), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH5A1(2), ALDH9A1(1), EHHADH(4), GAD1(3), GAD2(3), HADHA(2), L2HGDH(2), OXCT1(5), PDHA1(3), PDHA2(4), PDHB(1), SDHB(2)	36754818	66	55	65	23	11	15	13	15	12	0	0.760	1.000	1.000
480	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(4), ALOX5(3), CYP1A2(2), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), HSD3B7(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), RDH11(3), RDH12(2), RDH13(2), RDH14(2)	34402529	69	55	69	20	7	19	14	18	11	0	0.478	1.000	1.000
481	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(4), BLVRB(1), CP(7), EPRS(11), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), PPOX(5), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(5), UGT2B4(3), UROD(2), UROS(2)	39440600	74	55	73	30	5	23	15	20	10	1	0.963	1.000	1.000
482	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	BCAR1(6), CALM2(1), CRKL(1), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(3), PLCG1(8), PRKCA(4), PTK2B(6), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(1)	35151529	63	55	63	16	11	18	7	12	14	1	0.403	1.000	1.000
483	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(23), ASAH1(1), CASP3(1), CERK(2), CREB1(1), CREB5(5), CXCL2(1), DAG1(2), EPHB2(5), GNAQ(1), ITPKA(1), ITPKB(8), JUN(3), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1)	37629355	74	55	74	19	15	17	9	14	18	1	0.460	1.000	1.000
484	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(4), CD33(3), CD5(3), CD7(1), IFNA1(1), IFNG(2), IL12B(2), IL3(1), IL4(1), ITGAX(10), TLR2(3), TLR4(15), TLR7(9), TLR9(2)	26584788	65	54	64	23	7	15	17	13	13	0	0.741	1.000	1.000
485	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(3), CHIT1(3), CMAS(3), CTBS(1), CYB5R1(4), GFPT1(3), GFPT2(9), GNE(5), GNPDA2(2), GNPNAT1(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(3), NAGK(1), NPL(2), PGM3(2), UAP1(3)	41308047	69	54	68	17	11	22	13	14	9	0	0.340	1.000	1.000
486	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), GLCE(4), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), NDST1(4), NDST2(1), NDST3(5)	29037267	66	54	64	20	15	17	3	17	14	0	0.688	1.000	1.000
487	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(11), APOA1(3), APOA4(1), CETP(4), CYP7A1(3), DGAT1(2), HMGCR(4), LCAT(1), LDLR(4), LIPC(2), LPL(1), LRP1(27), SCARB1(4), SOAT1(2)	38209010	69	54	69	24	16	8	17	13	14	1	0.803	1.000	1.000
488	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(8), CALM2(1), CAPN2(8), EP300(13), HDAC1(6), HDAC2(2), MEF2D(3), NFATC1(5), NFATC2(4), PPP3CA(5), PPP3CB(2), PRKCA(4), SYT1(1)	33507887	62	53	62	23	8	15	9	13	17	0	0.933	1.000	1.000
489	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(23), CREBBP(15), EP300(13), MAP2K1(5), MAP3K7(3), MAPK3(1), SKIL(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4)	34676225	75	53	75	17	12	19	11	16	16	1	0.422	1.000	1.000
490	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(3), EPX(4), ESCO1(4), ESCO2(1), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PNPLA3(3), SH3GLB1(2), TAT(3), TPO(7)	47346097	71	52	70	19	14	16	11	15	14	1	0.483	1.000	1.000
491	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(4), AGT(3), AGTR1(4), AGTR2(2), COL4A1(10), COL4A2(10), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), REN(1)	37378954	71	51	71	20	12	16	15	13	15	0	0.391	1.000	1.000
492	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKCA(4), SP1(6), SP3(7), SYT1(1)	28045254	58	51	57	21	7	16	8	13	14	0	0.895	1.000	1.000
493	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(5), ARHGEF1(10), F2(2), F2R(4), GNA12(2), GNA13(1), GNAI1(2), GNAQ(1), GNB1(2), MAP3K7(3), PLCB1(12), PPP1R12B(4), PRKCA(4), PTK2B(6), ROCK1(8)	31056265	66	51	66	19	14	14	13	9	16	0	0.564	1.000	1.000
494	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	29	DUSP1(1), GORASP1(1), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PIK3CD(6), SYT1(1), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4)	38465136	59	51	59	15	16	11	8	11	12	1	0.357	1.000	1.000
495	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(10), COL4A2(10), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), P4HB(2), SLC23A1(1), SLC23A2(7), SLC2A3(3)	37265734	70	51	70	25	12	15	17	10	16	0	0.790	1.000	1.000
496	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2B1(6), MAN2B2(6), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2)	26889461	57	50	57	18	8	19	10	10	10	0	0.596	1.000	1.000
497	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AGPS(1), CHPT1(4), ENPP2(10), ENPP6(2), PAFAH1B1(3), PAFAH1B3(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLD1(7), PLD2(2), PPAP2A(2), PPAP2C(1)	33197621	60	50	60	16	6	18	13	13	10	0	0.394	1.000	1.000
498	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(7), AGT(3), AGTR2(2), EDN1(5), EDNRA(3), EDNRB(2), EGF(5), EGFR(5), HRAS(2), JUN(3), MYC(1), NFKB1(5), PLCG1(8), PRKCA(4), RELA(3)	29232806	58	49	57	20	10	15	6	16	11	0	0.814	1.000	1.000
499	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(5), EGFR(5), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), PTPRB(11), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SPRY1(7), SPRY2(2), SPRY3(6), SRC(1)	36128690	63	49	62	25	14	14	8	18	9	0	0.897	1.000	1.000
500	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(2), MRPS7(2), RPL10L(1), RPL12(1), RPL13A(4), RPL18(1), RPL18A(4), RPL19(2), RPL22L1(1), RPL24(1), RPL26(1), RPL3(2), RPL31(1), RPL32(1), RPL35(1), RPL36A(1), RPL37A(1), RPL3L(3), RPL41(1), RPL7(1), RPL8(2), RPL9(1), RPS10(1), RPS12(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS29(1), RPS5(6), RPS6(4), RPS8(1)	32180945	53	48	53	17	12	12	12	11	6	0	0.715	1.000	1.000
501	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(2), EIF4A1(2), EIF4A2(10), EIF4B(2), EIF4G1(9), EIF4G2(2), EIF4G3(5), MKNK1(2), PDK2(1), PDPK1(2), PPP2CA(3), RPS6(4), RPS6KB1(4), TSC1(5), TSC2(6)	32813847	59	48	58	15	11	25	4	10	9	0	0.460	1.000	1.000
502	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(1), ACAA2(2), ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), SOAT2(2), SRD5A1(4)	32771223	58	47	57	25	10	10	17	7	14	0	0.931	1.000	1.000
503	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(5), ACTN2(10), BCAR1(6), CTNNA1(7), CTNNA2(14), CTNNB1(2), PTK2(7), SRC(1), VCL(6)	27071688	58	47	57	19	15	11	4	13	14	1	0.729	1.000	1.000
504	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(3), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5), MASP1(4), MASP2(2), MBL2(2)	30356054	56	46	56	16	7	16	13	9	11	0	0.646	1.000	1.000
505	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(2), BHMT(1), CBS(1), CTH(3), DNMT1(8), DNMT3A(8), DNMT3B(3), MARS(9), MARS2(1), MAT1A(2), MAT2B(2), MTAP(1), MTR(5), SRM(4), TAT(3)	29405651	56	46	55	17	10	13	13	10	9	1	0.564	1.000	1.000
506	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(12), ARHGEF1(10), GNA12(2), GNA13(1), GNAQ(1), GNB1(2), MYLK(11), PLCB1(12), PPP1R12B(4), PRKCA(4), ROCK1(8)	29905414	67	46	67	17	9	10	14	12	22	0	0.515	1.000	1.000
507	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(9), AKT1(2), ATM(23), BAX(3), CDKN1A(1), CPB2(4), CSNK1A1(3), FHL2(2), HIF1A(4), MAPK8(2), MDM2(3), NFKBIB(1), NQO1(1)	27246646	58	46	57	22	8	19	6	11	14	0	0.971	1.000	1.000
508	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(24), MAP2(17), PPP2CA(3), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(2), PRKAR2B(2), PRKCE(8)	26168027	62	45	62	19	7	23	9	11	11	1	0.867	1.000	1.000
509	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(5), AKT1(2), ASAH1(1), GNAI1(2), GNB1(2), ITGAV(7), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(6), PLCB1(12), PRKCA(4), PTK2(7), SMPD1(2), SPHK1(1), SRC(1)	33331861	58	45	58	16	17	13	5	12	11	0	0.537	1.000	1.000
510	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), AOC2(6), AOC3(3), ASPA(4), CNDP1(7), DDC(3), HAL(7), HARS(2), HNMT(2), MAOA(2), MAOB(4), PRPS2(1)	33834606	65	45	64	20	11	13	15	10	16	0	0.589	1.000	1.000
511	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BNIP1(1), GOSR1(2), SNAP23(2), SNAP25(3), SNAP29(1), STX10(2), STX11(2), STX12(1), STX16(1), STX17(3), STX19(3), STX2(2), STX3(3), STX4(2), STX6(4), STX8(1), TSNARE1(4), USE1(2), VAMP1(1), VAMP2(1), VAMP3(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1A(1), VTI1B(2)	23423311	51	45	51	14	8	19	8	6	10	0	0.505	1.000	1.000
512	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(6), AP2A1(6), AP2M1(1), BIN1(2), CALM2(1), DNM1(6), EPN1(3), EPS15(6), PICALM(3), PPP3CA(5), PPP3CB(2), SYNJ1(3), SYNJ2(3), SYT1(1)	32308285	48	45	48	24	9	13	12	6	8	0	0.987	1.000	1.000
513	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(4), CREB1(1), CREBBP(15), EP300(13), NCOA3(10), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RARA(1), RXRA(2)	29330246	58	44	58	22	9	16	10	10	13	0	0.926	1.000	1.000
514	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(5), EPHB1(12), ITGA1(6), ITGB1(5), L1CAM(10), LYN(6), RAP1B(1), SELP(10)	22820566	58	44	58	22	15	10	12	16	4	1	0.850	1.000	1.000
515	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(4), POLR3H(1), POLR3K(1)	33367709	52	44	52	23	9	12	5	12	14	0	0.984	1.000	1.000
516	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(10), AMT(1), ATIC(3), ATP6V0C(1), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(3), TYMS(1)	25970247	50	44	49	17	4	17	9	6	14	0	0.794	1.000	1.000
517	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(23), AXIN1(5), BTRC(4), CTNNB1(2), DLL1(5), DVL1(2), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(2)	27714750	56	44	56	19	7	15	11	13	8	2	0.896	1.000	1.000
518	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(8), DYRK1B(1), GLI2(12), GLI3(11), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), SHH(1), SMO(5), SUFU(3)	21796902	55	44	55	18	11	18	10	8	8	0	0.626	1.000	1.000
519	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(3), C3(8), C5(5), C6(8), C7(8), C8A(2), C8B(3), C9(5), MASP1(4)	29518673	55	43	55	15	6	17	13	8	11	0	0.605	1.000	1.000
520	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(6), UGDH(1), UGP2(4), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), XYLB(2)	38241631	62	43	62	27	3	20	10	20	9	0	0.977	1.000	1.000
521	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(10), AMT(1), ATIC(3), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(3), TYMS(1)	27306571	49	43	48	17	3	17	9	6	14	0	0.834	1.000	1.000
522	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(7), BST1(2), CD38(3), ENPP1(7), ENPP3(5), NADK(1), NADSYN1(2), NMNAT1(2), NMNAT2(3), NNT(6), NT5C1A(2), NT5C1B(4), NT5C2(2), NT5E(4), NUDT12(2), QPRT(1)	30248575	53	43	53	21	5	15	7	17	9	0	0.928	1.000	1.000
523	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(8), ABCC2(7), ABCG2(1), BCHE(6), CES1(4), CES2(2), CYP3A4(4), CYP3A5(2), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2)	33210071	57	43	57	27	5	13	11	21	7	0	0.967	1.000	1.000
524	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(3), ICAM1(2), ITGA4(6), ITGAL(4), ITGAM(6), ITGB1(5), ITGB2(7), SELE(2), SELL(6), SELP(10)	23582555	51	43	51	20	5	11	11	14	10	0	0.915	1.000	1.000
525	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), HDAC5(6), MEF2A(6), MEF2C(4), MEF2D(3), PPARA(4), PPP3CA(5), PPP3CB(2), SLC2A4(1), SYT1(1)	29850433	55	43	55	20	4	16	8	17	10	0	0.850	1.000	1.000
526	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(2), EGFR(5), IGF1R(7), MYC(1), POLR2A(6), PPP2CA(3), PRKCA(4), TEP1(16), TERT(2), TNKS(5), XRCC5(3)	36196343	54	43	53	21	6	13	7	16	11	1	0.928	1.000	1.000
527	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CR1(12), CR2(5), HLA-DRB1(10), ICAM1(2), ITGAL(4), ITGB2(7), PTPRC(8)	21088677	48	42	48	24	3	16	12	10	6	1	0.983	1.000	1.000
528	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(5), F2(2), F2R(4), FGA(7), FGB(1), FGG(7), PLAT(6), PLG(7), SERPINB2(1), SERPINE1(5)	19628684	49	42	49	19	5	12	10	12	10	0	0.913	1.000	1.000
529	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(5), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(5), ILVBL(5), PANK1(2), PANK2(1), PANK4(5), UPB1(2), VNN1(3)	24239723	48	42	48	18	8	10	10	11	9	0	0.867	1.000	1.000
530	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), CYP2C19(6), CYP2C9(3), DHRS2(4), DHRS3(1), DHRS7(1), EHHADH(4), ESCO1(4), ESCO2(1), HADHA(2), PNPLA3(3), SH3GLB1(2), YOD1(1)	44048137	50	42	49	17	8	12	9	13	7	1	0.797	1.000	1.000
531	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(3), ELK1(4), HRAS(2), INSR(11), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SLC2A4(1), SOS1(5), SRF(1)	30098062	51	42	51	17	8	17	4	11	11	0	0.780	1.000	1.000
532	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), NCK1(2), NCKAP1(9), NTRK1(8), PIR(2), PSMA7(1), WASF1(6), WASF2(3), WASF3(5), WASL(4)	22194844	57	41	57	18	6	22	11	6	11	1	0.785	1.000	1.000
533	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(4), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2)	20795371	48	41	48	16	5	18	11	6	7	1	0.719	1.000	1.000
534	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME2(2), ME3(4), PGK1(7), PKLR(5), TKT(3), TPI1(2)	25442444	44	40	44	14	9	16	6	7	6	0	0.464	1.000	1.000
535	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(3), ELK1(4), HRAS(2), IGF1R(7), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1)	29048799	46	40	46	15	7	14	5	9	11	0	0.782	1.000	1.000
536	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(5), NCOA3(10), NCOR2(8), POLR2A(6), RARA(1), RXRA(2), TBP(2)	35597057	49	40	49	29	5	9	10	13	12	0	1.000	1.000	1.000
537	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CHUK(7), ELK1(4), HRAS(2), MAP2K1(5), MAPK3(1), NFKB1(5), RAF1(4), RALA(1), RALBP1(3), RALGDS(1), RELA(3), RHOA(6)	21978789	48	40	47	15	12	16	5	12	3	0	0.628	1.000	1.000
538	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(3), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5)	24715528	48	39	48	13	6	15	11	6	10	0	0.605	1.000	1.000
539	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(6), GABARAP(1), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(5), GPHN(5), NSF(2), SRC(1), UBQLN1(2)	17332649	46	39	46	14	8	16	10	8	4	0	0.554	1.000	1.000
540	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(5), IARS(8), IARS2(5), ILVBL(5), LARS(5), LARS2(3), PDHA1(3), PDHA2(4), PDHB(1), VARS(2), VARS2(1)	22951995	46	39	46	13	8	13	9	8	8	0	0.536	1.000	1.000
541	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	24	BAG4(1), BIRC2(3), BIRC3(4), CASP3(1), CFLAR(1), JUN(3), MAP3K3(1), MAP3K7(3), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NR2C2(1), RALBP1(3), RIPK1(5), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	33703170	52	39	51	19	11	17	7	5	12	0	0.856	1.000	1.000
542	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP1(3), ARFGAP3(1), ARFGEF2(9), COPA(8), GBF1(8), GPLD1(5), KDELR1(2), KDELR2(1), KDELR3(2)	23466812	41	38	41	12	6	17	6	5	5	2	0.552	1.000	1.000
543	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(9), ABCB11(13), ABCB4(10), ABCC1(8), ABCC3(8), GSTP1(1)	21341781	49	38	49	23	7	12	11	10	9	0	0.926	1.000	1.000
544	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(5), GALNT2(2), GALNT3(3), GALNT4(1), GALNT6(3), GALNT7(4), GALNT8(5), GALNT9(5), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), WBSCR17(7)	21154623	44	38	44	16	9	6	8	14	6	1	0.828	1.000	1.000
545	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(15), EP300(13), LPL(1), NCOA1(5), NCOA2(5), PPARG(5), RXRA(2)	26480845	46	38	45	18	9	8	9	9	11	0	0.948	1.000	1.000
546	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(3), EGF(5), EGFR(5), MET(10), PDGFRA(6), PRKCA(4), SH3GLB1(2), SH3GLB2(1), SH3KBP1(8), SRC(1)	28209889	49	37	48	24	9	13	6	14	7	0	0.989	1.000	1.000
547	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(4), ASPH(7), CREB1(1), EDN1(5), EP300(13), EPO(1), HIF1A(4), JUN(3), LDHA(2), NOS3(3), P4HB(2)	24048374	45	37	45	12	4	12	8	10	11	0	0.712	1.000	1.000
548	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(11), PTPRU(10), REG1A(1), STAT1(4), STAT2(5), TYK2(7)	17667029	40	37	38	13	6	5	11	8	10	0	0.767	1.000	1.000
549	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(11), ACE2(4), AGT(3), AGTR1(4), AGTR2(2), ANPEP(8), CPA3(1), CTSA(3), CTSG(1), ENPEP(9), LNPEP(2), MAS1(2), MME(1), NLN(1), REN(1), THOP1(1)	30097506	54	36	54	15	8	16	7	15	8	0	0.501	1.000	1.000
550	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), NPAS2(5), NR1D1(5), PER1(9), PER2(8), PER3(9)	23726746	50	36	50	20	11	11	7	12	9	0	0.955	1.000	1.000
551	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(4), CSF1(5), CSF3(2), HLA-DRB1(10), IFNA1(1), IFNG(2), IL11(1), IL12B(2), IL15(3), IL1A(1), IL3(1), IL4(1), IL6(1), IL7(1), LTA(2), TGFB1(2), TGFB2(1), TGFB3(1)	17969125	41	36	41	16	5	8	10	11	7	0	0.871	1.000	1.000
552	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(1), CBS(1), CTH(3), DNMT1(8), DNMT3A(8), DNMT3B(3), MARS(9), MARS2(1), MAT1A(2), MAT2B(2), MTR(5)	24760845	46	36	45	16	9	11	9	9	7	1	0.716	1.000	1.000
553	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(3), ELK1(4), HRAS(2), JUN(3), KLK2(3), MAP2K1(5), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(8), RAF1(4), SHC1(2), SOS1(5)	21265063	43	36	43	14	10	10	3	10	10	0	0.699	1.000	1.000
554	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(12), ACACB(10), FASN(14), MCAT(2), OLAH(1), OXSM(3)	21698172	42	35	42	17	7	12	7	8	8	0	0.883	1.000	1.000
555	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(5), ATP6V0C(1), CAT(2), EPX(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), SHMT1(1), SHMT2(3), TPO(7)	16857361	40	35	40	12	10	9	5	8	8	0	0.546	1.000	1.000
556	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(1), DRD1(1), DRD2(3), GRM1(9), PLCB1(12), PPP2CA(3), PPP3CA(5), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2)	22615585	48	34	48	14	7	17	7	8	9	0	0.462	1.000	1.000
557	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(2), DHCR24(4), DHCR7(1), EBP(1), FDFT1(4), FDPS(5), GGCX(3), GGPS1(2), HMGCR(4), IDI1(5), IDI2(1), LSS(2), NQO1(1), NSDHL(3), PMVK(2), SQLE(2)	27394456	45	34	44	22	7	16	5	12	5	0	0.979	1.000	1.000
558	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(2), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), GSK3B(2), IGF1R(7), INPPL1(6), PDK2(1), PDPK1(2), PPP2CA(3), RPS6(4), RPS6KB1(4)	21419127	43	34	43	15	6	19	6	4	7	1	0.788	1.000	1.000
559	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(3), ENPP1(7), ENPP3(5), NADSYN1(2), NMNAT1(2), NMNAT2(3), NNT(6), NT5E(4), QPRT(1)	20939180	40	34	40	18	3	13	6	11	7	0	0.956	1.000	1.000
560	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(5), AKT1(2), BAD(1), BAX(3), BCL2L1(1), CSF2RB(4), IGF1R(7), IL3(1), IL3RA(3), KIT(8), KITLG(3), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2)	25384437	50	33	50	16	8	19	7	5	11	0	0.530	1.000	1.000
561	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(11), GNB1(2), PPP2CA(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2)	21157763	44	33	44	17	11	10	7	8	8	0	0.925	1.000	1.000
562	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(2), POLQ(12)	23714375	38	33	37	12	6	7	6	9	9	1	0.798	1.000	1.000
563	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(5), PRKCE(8), SOD1(1)	11343299	38	33	38	15	5	12	10	7	4	0	0.865	1.000	1.000
564	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(1), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST3(1), CHST7(1), CHSY1(3), DSE(11), UST(2), XYLT1(4), XYLT2(5)	17166208	35	33	35	16	15	8	3	5	4	0	0.890	1.000	1.000
565	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(6), UCHL3(2), UGDH(1), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(5), UGT2B4(3)	25354389	42	33	42	21	2	11	8	16	5	0	0.979	1.000	1.000
566	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(12), CPT1A(6), LEP(1), LEPR(7), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2)	21055991	37	32	37	16	4	8	6	8	11	0	0.963	1.000	1.000
567	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGA4(6), ITGAL(4), ITGB1(5), ITGB2(7), SELE(2), SELL(6)	17677159	35	32	35	16	2	9	5	12	7	0	0.958	1.000	1.000
568	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	14	CD28(2), CD3E(3), CD3G(3), CD86(4), CTLA4(1), HLA-DRB1(10), ICOS(3), ITK(7), LCK(2), PTPN11(1)	12283086	36	31	36	13	2	14	9	7	4	0	0.815	1.000	1.000
569	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(4), ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2)	35859756	35	31	35	12	3	11	9	9	2	1	0.804	1.000	1.000
570	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(5), PANK1(2), PANK2(1), PANK4(5), UPB1(2)	19335387	35	31	35	15	4	8	7	9	7	0	0.942	1.000	1.000
571	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), HRAS(2), KLK2(3), NTRK1(8), PLCG1(8), PRKCA(4), SHC1(2), SOS1(5)	16733988	34	31	34	10	6	7	5	8	8	0	0.598	1.000	1.000
572	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5)	18645496	36	30	36	10	4	15	6	6	5	0	0.633	1.000	1.000
573	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(1), FDFT1(4), FDPS(5), HMGCR(4), HMGCS1(6), IDI1(5), LSS(2), NSDHL(3), PMVK(2), SQLE(2)	18751129	36	30	35	14	5	12	4	9	6	0	0.882	1.000	1.000
574	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(5), EGFR(5), MAP2K1(5), MAPK14(1), NCOR2(8), RARA(1), RXRA(2), THRA(3), THRB(2)	20030957	32	30	31	13	4	5	7	7	9	0	0.934	1.000	1.000
575	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACOT11(3), ACYP1(2), DHRS2(4), DHRS3(1), DHRS7(1), EHHADH(4), ESCO1(4), ESCO2(1), FN3K(3), GCDH(2), HADHA(2), PNPLA3(3), SH3GLB1(2), YOD1(1)	36932324	35	30	35	16	6	10	4	11	3	1	0.965	1.000	1.000
576	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(5), CAT(2), EPX(4), LPO(4), MPO(5), MTHFR(6), SHMT1(1), SHMT2(3), TPO(7)	16471638	37	30	37	11	10	11	3	7	6	0	0.487	1.000	1.000
577	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(15), DAXX(2), HRAS(2), PAX3(3), PML(1), RARA(1), SIRT1(2), SP100(7), TNFRSF1A(4), TNFRSF1B(2)	22091576	39	30	38	12	10	11	6	7	5	0	0.640	1.000	1.000
578	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(2), CD3E(3), CD3G(3), CD8A(3), ICAM1(2), ITGAL(4), ITGB2(7), PTPRC(8)	15067559	36	30	36	12	2	12	8	8	6	0	0.636	1.000	1.000
579	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(2), CD3E(3), CD3G(3), CD4(4), ICAM1(2), ITGAL(4), ITGB2(7), PTPRC(8)	16070091	37	30	37	15	2	11	8	8	8	0	0.844	1.000	1.000
580	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CCR5(1), CXCR4(3), GNAQ(1), JUN(3), MAPK14(1), MAPK8(2), PLCG1(8), PRKCA(4), PTK2B(6), SYT1(1)	19447194	32	29	32	14	5	7	5	4	11	0	0.953	1.000	1.000
581	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(3), ICAM1(2), ITGAL(4), ITGAM(6), ITGB2(7), SELE(2), SELL(6)	15584377	30	29	30	13	2	8	5	6	9	0	0.899	1.000	1.000
582	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(1), SHMT1(1)	23193960	40	29	40	19	7	13	7	4	9	0	0.943	1.000	1.000
583	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22104455	39	28	39	19	7	13	7	3	9	0	0.953	1.000	1.000
584	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(10), EGF(5), EGFR(5), HGS(6), TF(5), TFRC(2)	18331243	33	28	32	11	6	9	6	6	6	0	0.830	1.000	1.000
585	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22104455	39	28	39	19	7	13	7	3	9	0	0.953	1.000	1.000
586	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(1), JAK1(11), STAT1(4), STAT2(5), TYK2(7)	15421853	31	28	29	10	3	4	8	7	9	0	0.820	1.000	1.000
587	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(3), CD3G(3), CD4(4), HLA-DRB1(10), LCK(2), PTPRC(8), ZAP70(3)	12017733	33	28	33	18	2	8	9	7	7	0	0.989	1.000	1.000
588	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22104455	39	28	39	19	7	13	7	3	9	0	0.953	1.000	1.000
589	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), AOC2(6), AOC3(3), CES1(4), DDHD1(4), ESCO1(4), ESCO2(1), LIPA(3), PLA1A(3), PNPLA3(3), PPME1(2), SH3GLB1(2)	35979390	40	27	40	11	5	9	11	9	5	1	0.581	1.000	1.000
590	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(6), LDLR(4), MBTPS1(3), MBTPS2(6), SCAP(1), SREBF1(3), SREBF2(5)	15977732	28	27	28	16	3	6	11	4	4	0	0.955	1.000	1.000
591	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), CAMKK1(3), CAMKK2(3), CREB1(1), SYT1(1)	16476670	31	26	31	13	6	9	5	6	5	0	0.903	1.000	1.000
592	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(3), CD3G(3), HLA-A(3), ICAM1(2), ITGAL(4), ITGB2(7), PRF1(2)	11914239	27	26	26	15	3	8	3	9	4	0	0.963	1.000	1.000
593	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(9), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF5(2), GSK3B(2)	16407253	29	26	29	12	3	12	4	6	4	0	0.935	1.000	1.000
594	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(4), FDPS(5), HMGCR(4), IDI1(5), LSS(2), NQO1(1), NQO2(2), PMVK(2), SQLE(2)	15596846	28	25	27	13	4	9	4	7	4	0	0.947	1.000	1.000
595	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	14	IL4(1), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(5), NFATC2(4), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2)	13987299	27	25	27	12	3	10	7	3	4	0	0.837	1.000	1.000
596	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(16), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(2), PRKAR2B(2)	14388556	28	24	28	12	3	11	7	5	1	1	0.914	1.000	1.000
597	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALT1(3), B4GALT3(2), B4GALT4(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GCNT2(1), ST8SIA1(1)	20208777	27	24	27	12	5	8	4	7	3	0	0.879	1.000	1.000
598	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), EHHADH(4), HADHA(2)	17325132	26	24	25	12	3	4	8	4	7	0	0.930	1.000	1.000
599	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(2), JUN(3), MAPK3(1), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2)	18234872	27	23	27	18	4	7	6	5	5	0	0.998	1.000	1.000
600	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5)	18100668	28	22	28	16	6	8	1	7	6	0	0.994	1.000	1.000
601	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(11), CASP3(1), CASP9(2), DAXX(2), FAS(1), FASLG(2), IL1A(1), MAPKAPK2(1), MAPKAPK3(2)	15469859	26	21	26	10	3	11	5	3	3	1	0.846	1.000	1.000
602	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(3), ANKRD1(2), ATF3(2), CYR61(3), IFNG(2), IFRD1(2), IL18(2), IL1A(1), IL1R1(1), NR4A3(3), WDR1(1)	15407183	22	21	22	12	3	7	4	7	1	0	0.967	1.000	1.000
603	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(2), CD4(4), HLA-DRB1(10), IL4(1), IL5RA(4), IL6(1)	6929695	23	21	23	10	1	4	6	6	6	0	0.915	1.000	1.000
604	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), WASF1(6), WASL(4)	11863193	27	21	27	13	3	12	6	0	5	1	0.960	1.000	1.000
605	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(1), GPR161(6), GPR34(4), GPR39(3), GPR45(2), GPR65(1), GPR75(3)	14277703	25	20	25	11	2	4	2	13	4	0	0.894	1.000	1.000
606	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), IFNAR1(2), IFNAR2(1), MAPK8(2), NFKB1(5), RELA(3), TNFRSF11A(2), TRAF6(4)	15304799	20	20	20	10	5	4	3	4	4	0	0.950	1.000	1.000
607	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(3), SNCA(1), SNCAIP(7), UBE2F(1), UBE2L3(1), UBE2L6(2)	9052388	20	19	20	10	3	8	4	4	1	0	0.955	1.000	1.000
608	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), PAK1(3), PDGFRA(6), WASL(4)	14124386	27	18	27	11	4	15	2	0	6	0	0.843	1.000	1.000
609	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(4), JUN(3), MAPK14(1), THBS1(8)	10280621	17	14	16	10	3	0	1	2	11	0	0.997	1.000	1.000
610	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACYP1(2), EHHADH(4), GCDH(2), HADHA(2), SDHB(2)	11272198	14	13	14	6	2	5	2	5	0	0	0.815	1.000	1.000
611	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(3), ADORA3(1), P2RY1(4), P2RY2(1), P2RY6(1)	7788787	13	13	13	6	5	0	5	3	0	0	0.722	1.000	1.000
612	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(3), NDUFA1(2), SDHB(2), UQCRC1(1)	9419011	11	10	11	6	2	1	2	6	0	0	0.921	1.000	1.000
613	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADS(2), ACAT1(2), HADHA(2)	7615747	7	7	7	4	1	2	1	3	0	0	0.905	1.000	1.000
614	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(2), FMOD(1), KERA(3), LUM(2)	5259739	10	7	10	7	2	5	2	1	0	0	0.955	1.000	1.000
615	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	B3GNT1(1), FUT1(1), GCNT2(1), ST8SIA1(1)	7756482	4	4	4	6	0	1	0	3	0	0	0.998	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(1)	2220249	2	2	2	2	0	1	0	1	0	0	0.973	1.000	1.000