E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.016 0.092 -9999.0 0.0 -0.577 28.0 28.0 KLHL20 -0.008 0.031 -9999.0 0.0 -0.24 3.0 3.0 CYFIP2 -0.01 0.065 -9999.0 0.0 -0.357 31.0 31.0 Rac1/GDP 0.05 0.065 -9999.0 0.0 -0.341 28.0 28.0 ENAH -0.015 0.091 -9999.0 0.0 -0.573 28.0 28.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.008 0.045 -9999.0 0.0 -0.491 1.0 1.0 ABI1/Sra1/Nap1 -0.006 0.023 -9999.0 0.0 -0.186 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.016 0.078 -9999.0 0.0 -0.468 30.0 30.0 RAPGEF1 0.04 0.085 -9999.0 0.0 -0.478 28.0 28.0 CTNND1 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.095 -9999.0 0.0 -0.596 28.0 28.0 CRK 0.032 0.092 -9999.0 0.0 -0.528 28.0 28.0 E-cadherin/gamma catenin/alpha catenin -0.014 0.083 -9999.0 0.0 -0.516 29.0 29.0 alphaE/beta7 Integrin -0.006 0.04 -9999.0 0.0 -0.6 2.0 2.0 IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.003 0.035 -9999.0 0.0 -0.476 6.0 6.0 DLG1 -0.015 0.091 -9999.0 0.0 -0.573 28.0 28.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.039 -9999.0 0.0 -0.311 2.0 2.0 MLLT4 -0.005 0.059 -9999.0 0.0 -0.717 7.0 7.0 ARF6/GTP/NME1/Tiam1 -0.007 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.01 0.051 -9999.0 0.0 -0.421 2.0 2.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.016 0.097 -9999.0 0.0 -0.6 29.0 29.0 TIAM1 -0.001 0.018 -9999.0 0.0 -0.293 4.0 4.0 E-cadherin(dimer)/Ca2+ -0.011 0.07 -9999.0 0.0 -0.444 28.0 28.0 AKT1 -0.006 0.028 -9999.0 0.0 -0.22 2.0 2.0 PIK3R1 -0.01 0.089 -9999.0 0.0 -0.787 14.0 14.0 CDH1 -0.02 0.124 -9999.0 0.0 -0.787 28.0 28.0 RhoA/GDP 0.05 0.065 -9999.0 0.0 -0.342 28.0 28.0 actin cytoskeleton organization -0.006 0.023 -9999.0 0.0 -0.174 3.0 3.0 CDC42/GDP 0.05 0.065 -9999.0 0.0 -0.342 28.0 28.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.009 0.054 -9999.0 0.0 -0.333 29.0 29.0 ITGB7 -0.009 0.058 -9999.0 0.0 -0.324 32.0 32.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.012 0.074 -9999.0 0.0 -0.468 28.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.012 0.071 -9999.0 0.0 -0.452 28.0 28.0 mol:GDP 0.047 0.075 -9999.0 0.0 -0.408 28.0 28.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.001 0.025 -9999.0 0.0 -0.54 2.0 2.0 p120 catenin/RhoA/GDP -0.009 0.056 -9999.0 0.0 -0.444 2.0 2.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.029 -9999.0 0.0 -0.215 7.0 7.0 NME1 -0.015 0.065 -9999.0 0.0 -0.293 56.0 56.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.015 0.092 -9999.0 0.0 -0.567 29.0 29.0 regulation of cell-cell adhesion -0.007 0.04 -9999.0 0.0 -0.416 1.0 1.0 WASF2 -0.003 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.009 0.053 -9999.0 0.0 -0.583 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.015 0.074 -9999.0 0.0 -0.436 31.0 31.0 CCND1 -0.009 0.035 -9999.0 0.0 -0.27 7.0 7.0 VAV2 0.036 0.089 -9999.0 0.0 -0.506 28.0 28.0 RAP1/GDP -0.009 0.053 -9999.0 0.0 -0.561 1.0 1.0 adherens junction assembly -0.015 0.088 -9999.0 0.0 -0.546 29.0 29.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.014 0.07 -9999.0 0.0 -0.413 31.0 31.0 E-cadherin/beta catenin -0.012 0.077 -9999.0 0.0 -0.487 28.0 28.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.015 0.091 -9999.0 0.0 -0.573 28.0 28.0 PIK3CA -0.0 0.009 -9999.0 0.0 -0.293 1.0 1.0 Rac1/GTP -0.01 0.051 -9999.0 0.0 -0.353 6.0 6.0 E-cadherin/beta catenin/alpha catenin -0.013 0.082 -9999.0 0.0 -0.516 28.0 28.0 ITGAE 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.016 0.097 -9999.0 0.0 -0.613 28.0 28.0