Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.054 0.299 -9999.0 0.0 -0.814 131.0 131.0 IHH -0.014 0.082 -9999.0 0.0 -0.417 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.032 0.117 -9999.0 0.0 -0.488 66.0 66.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.032 0.116 0.484 66.0 -9999.0 0.0 66.0 SMO/beta Arrestin2 -0.076 0.232 -9999.0 0.0 -0.844 82.0 82.0 SMO -0.036 0.265 -9999.0 0.0 -0.855 91.0 91.0 AKT1 0.006 0.121 -9999.0 0.0 -0.448 28.0 28.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.058 0.206 -9999.0 0.0 -0.787 81.0 81.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.035 0.257 -9999.0 0.0 -0.831 91.0 91.0 STIL -0.039 0.21 -9999.0 0.0 -0.696 86.0 86.0 DHH N/PTCH2 -0.061 0.19 -9999.0 0.0 -0.633 104.0 104.0 DHH N/PTCH1 -0.09 0.241 -9999.0 0.0 -0.739 116.0 116.0 PIK3CA -0.0 0.009 -9999.0 0.0 -0.293 1.0 1.0 DHH -0.022 0.129 -9999.0 0.0 -0.756 32.0 32.0 PTHLH -0.081 0.38 -9999.0 0.0 -1.06 131.0 131.0 determination of left/right symmetry -0.035 0.257 -9999.0 0.0 -0.831 91.0 91.0 PIK3R1 -0.01 0.089 -9999.0 0.0 -0.787 14.0 14.0 skeletal system development -0.079 0.371 -9999.0 0.0 -1.036 131.0 131.0 IHH N/Hhip -0.009 0.051 -9999.0 0.0 -0.532 3.0 3.0 DHH N/Hhip -0.019 0.104 -9999.0 0.0 -0.61 32.0 32.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.035 0.257 -9999.0 0.0 -0.831 91.0 91.0 pancreas development -0.003 0.041 -9999.0 0.0 -0.402 9.0 9.0 HHAT -0.001 0.024 -9999.0 0.0 -0.787 1.0 1.0 PI3K -0.008 0.068 -9999.0 0.0 -0.6 14.0 14.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.047 0.186 -9999.0 0.0 -0.787 65.0 65.0 somite specification -0.035 0.257 -9999.0 0.0 -0.831 91.0 91.0 SHH Np/Cholesterol/PTCH1 -0.071 0.205 -9999.0 0.0 -0.712 91.0 91.0 SHH Np/Cholesterol/PTCH2 -0.039 0.128 -9999.0 0.0 -0.485 82.0 82.0 SHH Np/Cholesterol/Megalin -0.135 0.213 -9999.0 0.0 -0.485 292.0 292.0 SHH 0.01 0.035 -9999.0 0.0 -0.609 1.0 1.0 catabolic process -0.047 0.258 -9999.0 0.0 -0.819 97.0 97.0 SMO/Vitamin D3 -0.075 0.225 -9999.0 0.0 -0.813 83.0 83.0 SHH Np/Cholesterol/Hhip -0.005 0.035 -9999.0 0.0 -0.38 6.0 6.0 LRP2 -0.217 0.347 -9999.0 0.0 -0.745 318.0 318.0 receptor-mediated endocytosis -0.149 0.252 -9999.0 0.0 -0.821 99.0 99.0 SHH Np/Cholesterol/BOC -0.039 0.129 -9999.0 0.0 -0.487 82.0 82.0 SHH Np/Cholesterol/CDO -0.009 0.059 -9999.0 0.0 -0.48 15.0 15.0 mesenchymal cell differentiation 0.005 0.035 0.378 6.0 -9999.0 0.0 6.0 mol:Vitamin D3 -0.03 0.221 -9999.0 0.0 -0.716 91.0 91.0 IHH N/PTCH2 -0.055 0.179 -9999.0 0.0 -0.673 81.0 81.0 CDON -0.01 0.089 -9999.0 0.0 -0.787 14.0 14.0 IHH N/PTCH1 -0.045 0.261 -9999.0 0.0 -0.826 97.0 97.0 Megalin/LRPAP1 -0.164 0.264 -9999.0 0.0 -0.6 291.0 291.0 PTCH2 -0.058 0.206 -9999.0 0.0 -0.787 81.0 81.0 SHH Np/Cholesterol -0.003 0.025 -9999.0 0.0 -0.492 1.0 1.0 PTCH1 -0.047 0.259 -9999.0 0.0 -0.824 97.0 97.0 HHIP -0.003 0.041 -9999.0 0.0 -0.403 9.0 9.0