Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.009 0.052 -9999.0 0.0 -0.323 29.0 29.0 epithelial cell differentiation -0.011 0.069 -9999.0 0.0 -0.439 28.0 28.0 CYFIP2 -0.01 0.065 -9999.0 0.0 -0.357 31.0 31.0 ENAH 0.058 0.057 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.293 0.38 -9999.0 0.0 -0.781 410.0 410.0 EPHA2 -0.004 0.058 -9999.0 0.0 -0.787 6.0 6.0 MYO6 -0.011 0.067 -9999.0 0.0 -0.415 29.0 29.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.038 -9999.0 0.0 -0.516 4.0 4.0 AQP5 -0.231 0.288 -9999.0 0.0 -0.582 428.0 428.0 CTNND1 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.011 0.065 -9999.0 0.0 -0.408 28.0 28.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.111 -9999.0 0.0 -0.414 85.0 85.0 EGF -0.153 0.311 -9999.0 0.0 -0.783 214.0 214.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.037 0.14 -9999.0 0.0 -0.587 56.0 56.0 cortical microtubule organization -0.011 0.069 -9999.0 0.0 -0.439 28.0 28.0 GO:0000145 0.027 0.068 -9999.0 0.0 -0.39 28.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.011 0.07 -9999.0 0.0 -0.444 28.0 28.0 MLLT4 -0.005 0.059 -9999.0 0.0 -0.717 7.0 7.0 ARF6/GDP -0.011 0.059 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.036 -9999.0 0.0 -0.468 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.037 0.071 -9999.0 0.0 -0.381 28.0 28.0 PVRL2 -0.001 0.015 -9999.0 0.0 -0.293 3.0 3.0 ZYX -0.011 0.066 -9999.0 0.0 -0.415 28.0 28.0 ARF6/GTP -0.003 0.033 -9999.0 0.0 -0.429 6.0 6.0 CDH1 -0.02 0.124 -9999.0 0.0 -0.787 28.0 28.0 EGFR/EGFR/EGF/EGF -0.238 0.256 -9999.0 0.0 -0.463 562.0 562.0 RhoA/GDP -0.011 0.065 -9999.0 0.0 -0.41 28.0 28.0 actin cytoskeleton organization 0.033 0.07 -9999.0 0.0 -0.391 29.0 29.0 IGF-1R heterotetramer -0.02 0.115 -9999.0 0.0 -0.594 36.0 36.0 GIT1 -0.001 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.02 0.115 -9999.0 0.0 -0.595 36.0 36.0 IGF1 -0.178 0.329 -9999.0 0.0 -0.787 247.0 247.0 DIAPH1 -0.002 0.043 -9999.0 0.0 -0.692 4.0 4.0 Wnt receptor signaling pathway 0.011 0.069 0.439 28.0 -9999.0 0.0 28.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.011 0.06 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.033 0.072 -9999.0 0.0 -0.401 29.0 29.0 EFNA1 -0.0 0.009 -9999.0 0.0 -0.293 1.0 1.0 LPP 0.031 0.078 -9999.0 0.0 -0.392 36.0 36.0 Ephrin A1/EPHA2 -0.012 0.069 -9999.0 0.0 -0.397 34.0 34.0 SEC6/SEC8 -0.012 0.065 -9999.0 0.0 -0.744 1.0 1.0 MGAT3 -0.033 0.113 -9999.0 0.0 -0.421 85.0 85.0 HGF/MET -0.107 0.2 -9999.0 0.0 -0.445 262.0 262.0 HGF -0.053 0.197 -9999.0 0.0 -0.787 73.0 73.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.009 0.052 -9999.0 0.0 -0.325 29.0 29.0 actin cable formation 0.072 0.055 -9999.0 0.0 -0.321 1.0 1.0 KIAA1543 0.032 0.087 -9999.0 0.0 -0.458 29.0 29.0 KIFC3 -0.011 0.068 -9999.0 0.0 -0.416 30.0 30.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.011 0.067 -9999.0 0.0 -0.415 29.0 29.0 NCK1/GIT1 -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.011 0.069 -9999.0 0.0 -0.439 28.0 28.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.011 0.066 -9999.0 0.0 -0.415 28.0 28.0 PIP5K1C -0.011 0.066 -9999.0 0.0 -0.415 28.0 28.0 LIMA1 -0.001 0.024 -9999.0 0.0 -0.787 1.0 1.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.053 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.048 0.083 -9999.0 0.0 -0.621 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.11 0.194 -9999.0 0.0 -0.429 279.0 279.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.004 0.046 -9999.0 0.0 -0.6 6.0 6.0 MET -0.136 0.297 -9999.0 0.0 -0.785 189.0 189.0 PLEKHA7 -0.012 0.076 -9999.0 0.0 -0.461 28.0 28.0 mol:GTP -0.003 0.035 -9999.0 0.0 -0.465 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.011 0.061 -9999.0 0.0 -0.699 1.0 1.0 cortical actin cytoskeleton stabilization -0.009 0.052 -9999.0 0.0 -0.323 29.0 29.0 regulation of cell-cell adhesion 0.033 0.07 -9999.0 0.0 -0.391 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.009 0.052 -9999.0 0.0 -0.325 29.0 29.0