E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.019 0.11 -9999.0 0.0 -0.426 34.0 34.0 KLHL20 0.016 0.064 0.242 8.0 -0.222 13.0 21.0 CYFIP2 0.028 0.048 0.255 26.0 -0.566 3.0 29.0 Rac1/GDP 0.001 0.084 0.26 8.0 -0.308 17.0 25.0 ENAH -0.015 0.103 -9999.0 0.0 -0.449 24.0 24.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.046 -9999.0 0.0 -0.325 2.0 2.0 ABI1/Sra1/Nap1 -0.012 0.031 -9999.0 0.0 -0.158 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.064 -9999.0 0.0 -0.331 20.0 20.0 RAPGEF1 -0.018 0.105 0.258 2.0 -0.393 28.0 30.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.122 -9999.0 0.0 -0.41 50.0 50.0 CRK -0.015 0.099 -9999.0 0.0 -0.417 30.0 30.0 E-cadherin/gamma catenin/alpha catenin 0.033 0.057 -9999.0 0.0 -0.361 18.0 18.0 alphaE/beta7 Integrin 0.036 0.034 -9999.0 0.0 -0.419 2.0 2.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.027 -9999.0 0.0 -0.329 3.0 3.0 DLG1 -0.023 0.116 -9999.0 0.0 -0.443 32.0 32.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.031 -9999.0 0.0 -0.211 4.0 4.0 MLLT4 0.021 0.032 0.255 1.0 -0.566 3.0 4.0 ARF6/GTP/NME1/Tiam1 0.044 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.003 0.045 -9999.0 0.0 -0.288 3.0 3.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.021 0.062 -9999.0 0.0 -0.419 18.0 18.0 TIAM1 0.025 0.015 0.255 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.041 0.054 -9999.0 0.0 -0.312 18.0 18.0 AKT1 -0.007 0.035 0.137 1.0 -0.209 1.0 2.0 PIK3R1 0.016 0.065 -9999.0 0.0 -0.566 13.0 13.0 CDH1 0.012 0.076 -9999.0 0.0 -0.566 18.0 18.0 RhoA/GDP 0.002 0.083 0.259 8.0 -0.31 16.0 24.0 actin cytoskeleton organization 0.015 0.052 0.184 18.0 -0.164 11.0 29.0 CDC42/GDP 0.002 0.082 0.257 9.0 -0.31 16.0 25.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.04 -9999.0 0.0 -0.265 18.0 18.0 ITGB7 0.03 0.046 0.255 30.0 -0.566 2.0 32.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.045 0.057 -9999.0 0.0 -0.331 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.03 0.049 -9999.0 0.0 -0.31 18.0 18.0 mol:GDP -0.012 0.09 0.264 9.0 -0.356 17.0 26.0 CDC42/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.006 0.085 0.261 7.0 -0.318 16.0 23.0 RAC1/GTP/IQGAP1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.047 0.175 39.0 -0.238 4.0 43.0 NME1 0.026 0.031 0.255 18.0 -9999.0 0.0 18.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.114 -9999.0 0.0 -0.447 31.0 31.0 regulation of cell-cell adhesion 0.004 0.039 -9999.0 0.0 -0.282 2.0 2.0 WASF2 0.008 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.014 0.056 0.237 3.0 -0.367 2.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.054 0.064 -9999.0 0.0 -0.315 19.0 19.0 CCND1 0.015 0.054 0.198 38.0 -0.3 4.0 42.0 VAV2 -0.018 0.147 -9999.0 0.0 -0.55 36.0 36.0 RAP1/GDP 0.008 0.069 0.261 4.0 -0.347 3.0 7.0 adherens junction assembly -0.02 0.111 -9999.0 0.0 -0.432 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.061 -9999.0 0.0 -0.305 19.0 19.0 E-cadherin/beta catenin 0.001 0.057 -9999.0 0.0 -0.34 28.0 28.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.022 0.115 -9999.0 0.0 -0.436 32.0 32.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.004 0.089 0.255 34.0 -0.338 25.0 59.0 E-cadherin/beta catenin/alpha catenin 0.034 0.057 -9999.0 0.0 -0.361 18.0 18.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.124 -9999.0 0.0 -0.419 50.0 50.0