Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.014 0.139 0.42 85.0 -0.244 2.0 87.0 KIRREL -0.024 0.163 -9999.0 0.0 -0.571 87.0 87.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.014 0.14 0.244 2.0 -0.421 85.0 87.0 PLCG1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.034 0.117 0.289 3.0 -0.319 84.0 87.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.008 0.088 0.236 1.0 -0.28 70.0 71.0 FYN 0.013 0.128 0.27 110.0 -0.305 83.0 193.0 mol:Ca2+ 0.031 0.113 0.278 3.0 -0.317 79.0 82.0 mol:DAG 0.032 0.114 0.283 3.0 -0.318 79.0 82.0 NPHS2 0.014 0.032 0.262 5.0 -9999.0 0.0 5.0 mol:IP3 0.032 0.114 0.283 3.0 -0.318 79.0 82.0 regulation of endocytosis 0.023 0.104 0.244 4.0 -0.289 83.0 87.0 Nephrin/NEPH1/podocin/Cholesterol 0.023 0.112 0.25 9.0 -0.317 84.0 93.0 establishment of cell polarity 0.014 0.139 0.244 2.0 -0.42 85.0 87.0 Nephrin/NEPH1/podocin/NCK1-2 0.043 0.113 0.317 1.0 -0.295 82.0 83.0 Nephrin/NEPH1/beta Arrestin2 0.026 0.107 0.252 4.0 -0.292 83.0 87.0 NPHS1 0.058 0.09 0.257 166.0 -9999.0 0.0 166.0 Nephrin/NEPH1/podocin 0.024 0.11 0.303 4.0 -0.307 83.0 87.0 TJP1 0.023 0.019 -9999.0 0.0 -0.566 1.0 1.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.033 0.115 0.288 3.0 -0.319 79.0 82.0 CD2AP 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.031 0.115 0.324 2.0 -0.319 81.0 83.0 GRB2 0.023 0.009 0.255 1.0 -9999.0 0.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.012 0.132 0.286 97.0 -0.306 89.0 186.0 cytoskeleton organization 0.003 0.108 0.289 12.0 -0.331 66.0 78.0 Nephrin/NEPH1 0.016 0.103 0.2 2.0 -0.298 85.0 87.0 Nephrin/NEPH1/ZO-1 0.025 0.121 -9999.0 0.0 -0.343 85.0 85.0