Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.012 0.041 -9999.0 0.0 -0.259 19.0 19.0 epithelial cell differentiation 0.037 0.052 -9999.0 0.0 -0.309 18.0 18.0 CYFIP2 0.028 0.048 0.255 26.0 -0.566 3.0 29.0 ENAH -0.003 0.059 0.295 11.0 -9999.0 0.0 11.0 EGFR -0.191 0.284 -9999.0 0.0 -0.566 390.0 390.0 EPHA2 0.02 0.04 -9999.0 0.0 -0.566 5.0 5.0 MYO6 -0.011 0.05 0.361 1.0 -0.3 19.0 20.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.034 -9999.0 0.0 -0.361 3.0 3.0 AQP5 -0.181 0.257 0.308 2.0 -0.495 419.0 421.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.011 0.049 0.358 1.0 -0.295 18.0 19.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.074 0.358 1.0 -0.294 62.0 63.0 EGF -0.082 0.227 0.255 2.0 -0.566 194.0 196.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.015 0.117 0.287 1.0 -0.466 55.0 56.0 cortical microtubule organization 0.037 0.052 -9999.0 0.0 -0.309 18.0 18.0 GO:0000145 -0.011 0.046 0.351 1.0 -0.282 18.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.041 0.053 -9999.0 0.0 -0.312 18.0 18.0 MLLT4 0.021 0.032 0.255 1.0 -0.566 3.0 4.0 ARF6/GDP -0.02 0.037 -9999.0 0.0 -0.273 18.0 18.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.038 -9999.0 0.0 -0.328 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.0 0.048 -9999.0 0.0 -0.282 18.0 18.0 PVRL2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.011 0.049 0.361 1.0 -0.299 18.0 19.0 ARF6/GTP 0.049 0.04 -9999.0 0.0 -0.308 5.0 5.0 CDH1 0.012 0.076 -9999.0 0.0 -0.566 18.0 18.0 EGFR/EGFR/EGF/EGF -0.141 0.195 -9999.0 0.0 -0.329 519.0 519.0 RhoA/GDP 0.038 0.051 -9999.0 0.0 -0.296 18.0 18.0 actin cytoskeleton organization -0.012 0.047 0.343 1.0 -0.292 19.0 20.0 IGF-1R heterotetramer 0.013 0.079 0.255 3.0 -0.565 19.0 22.0 GIT1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.079 0.255 3.0 -0.566 19.0 22.0 IGF1 -0.104 0.243 -9999.0 0.0 -0.566 233.0 233.0 DIAPH1 0.026 0.1 -9999.0 0.0 -0.554 15.0 15.0 Wnt receptor signaling pathway -0.037 0.052 0.309 18.0 -9999.0 0.0 18.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.037 -9999.0 0.0 -0.275 15.0 15.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.013 0.048 0.346 1.0 -0.298 19.0 20.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.014 0.052 -9999.0 0.0 -0.289 25.0 25.0 Ephrin A1/EPHA2 0.026 0.051 -9999.0 0.0 -0.291 20.0 20.0 SEC6/SEC8 -0.021 0.04 -9999.0 0.0 -0.295 19.0 19.0 MGAT3 -0.022 0.075 0.361 1.0 -0.299 62.0 63.0 HGF/MET -0.039 0.152 -9999.0 0.0 -0.316 232.0 232.0 HGF -0.011 0.141 0.255 2.0 -0.566 65.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.012 0.042 -9999.0 0.0 -0.261 19.0 19.0 actin cable formation 0.042 0.094 0.323 34.0 -0.291 1.0 35.0 KIAA1543 -0.012 0.053 0.354 1.0 -0.33 18.0 19.0 KIFC3 -0.012 0.047 0.361 1.0 -0.299 18.0 19.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.011 0.048 -9999.0 0.0 -0.299 18.0 18.0 NCK1/GIT1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.037 0.052 -9999.0 0.0 -0.309 18.0 18.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.011 0.047 0.361 1.0 -0.299 17.0 18.0 PIP5K1C -0.011 0.05 0.361 1.0 -0.299 18.0 19.0 LIMA1 0.024 0.018 -9999.0 0.0 -0.566 1.0 1.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.017 0.088 0.311 26.0 -9999.0 0.0 26.0 adherens junction assembly -0.021 0.102 0.298 3.0 -0.629 16.0 19.0 IGF-1R heterotetramer/IGF1 -0.041 0.147 -9999.0 0.0 -0.307 234.0 234.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.029 -9999.0 0.0 -0.295 6.0 6.0 MET -0.073 0.219 -9999.0 0.0 -0.566 177.0 177.0 PLEKHA7 -0.012 0.056 0.361 1.0 -0.346 18.0 19.0 mol:GTP 0.043 0.037 -9999.0 0.0 -0.326 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.007 0.066 0.367 7.0 -0.513 1.0 8.0 cortical actin cytoskeleton stabilization 0.012 0.041 -9999.0 0.0 -0.259 19.0 19.0 regulation of cell-cell adhesion -0.012 0.047 0.343 1.0 -0.292 19.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.012 0.042 -9999.0 0.0 -0.261 19.0 19.0