E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.036 0.148 -9999.0 0.0 -0.45 35.0 35.0 KLHL20 0.042 0.114 0.301 42.0 -0.258 14.0 56.0 CYFIP2 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.003 0.117 0.318 6.0 -0.348 6.0 12.0 ENAH -0.03 0.143 -9999.0 0.0 -0.448 31.0 31.0 AP1M1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.052 -9999.0 0.0 -0.543 4.0 4.0 CDC42/GTP 0.009 0.075 -9999.0 0.0 -0.29 2.0 2.0 ABI1/Sra1/Nap1 -0.015 0.04 -9999.0 0.0 -0.181 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.095 -9999.0 0.0 -0.314 25.0 25.0 RAPGEF1 -0.029 0.142 0.335 1.0 -0.403 37.0 38.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.164 -9999.0 0.0 -0.447 47.0 47.0 CRK -0.026 0.145 0.346 1.0 -0.432 38.0 39.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.089 -9999.0 0.0 -0.343 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.054 0.042 -9999.0 0.0 -0.309 3.0 3.0 DLG1 -0.038 0.158 -9999.0 0.0 -0.453 40.0 40.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.218 6.0 6.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.542 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.08 -9999.0 0.0 -0.29 5.0 5.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.021 0.095 -9999.0 0.0 -0.399 21.0 21.0 TIAM1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.047 0.089 -9999.0 0.0 -0.295 25.0 25.0 AKT1 -0.007 0.056 -9999.0 0.0 -0.197 1.0 1.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.543 47.0 47.0 CDH1 0.007 0.118 -9999.0 0.0 -0.542 22.0 22.0 RhoA/GDP 0.002 0.116 0.326 4.0 -0.349 6.0 10.0 actin cytoskeleton organization 0.037 0.093 0.253 44.0 -0.19 12.0 56.0 CDC42/GDP 0.001 0.116 0.326 4.0 -0.347 6.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.005 0.066 -9999.0 0.0 -0.251 23.0 23.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.051 0.095 -9999.0 0.0 -0.314 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.082 -9999.0 0.0 -0.29 26.0 26.0 mol:GDP -0.017 0.123 0.331 4.0 -0.348 25.0 29.0 CDC42/GTP/IQGAP1 0.043 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.008 0.12 0.341 3.0 -0.369 5.0 8.0 RAC1/GTP/IQGAP1 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.067 0.216 20.0 -0.225 11.0 31.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.157 -9999.0 0.0 -0.461 39.0 39.0 regulation of cell-cell adhesion -0.001 0.061 -9999.0 0.0 -0.255 2.0 2.0 WASF2 0.02 0.043 0.118 32.0 -0.119 2.0 34.0 Rap1/GTP 0.013 0.087 0.281 1.0 -0.327 2.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.092 -9999.0 0.0 -0.299 21.0 21.0 CCND1 0.017 0.079 0.244 20.0 -0.283 11.0 31.0 VAV2 -0.018 0.192 0.413 1.0 -0.662 16.0 17.0 RAP1/GDP 0.012 0.101 0.311 3.0 -0.349 4.0 7.0 adherens junction assembly -0.034 0.154 -9999.0 0.0 -0.445 39.0 39.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.045 0.088 -9999.0 0.0 -0.288 24.0 24.0 E-cadherin/beta catenin -0.006 0.089 -9999.0 0.0 -0.335 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.036 0.157 -9999.0 0.0 -0.45 41.0 41.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.013 0.144 0.279 59.0 -0.423 17.0 76.0 E-cadherin/beta catenin/alpha catenin 0.036 0.095 -9999.0 0.0 -0.339 26.0 26.0 ITGAE 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.167 -9999.0 0.0 -0.457 47.0 47.0