Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.237 0.588 2.0 -0.556 74.0 76.0 IHH 0.021 0.074 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.068 0.148 -9999.0 0.0 -0.314 128.0 128.0 LRPAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.068 0.147 0.312 128.0 -9999.0 0.0 128.0 SMO/beta Arrestin2 -0.001 0.185 0.41 2.0 -0.485 28.0 30.0 SMO -0.016 0.183 0.441 2.0 -0.502 29.0 31.0 AKT1 -0.02 0.191 0.306 1.0 -0.593 37.0 38.0 ARRB2 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.091 0.237 -9999.0 0.0 -0.543 111.0 111.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.015 0.181 0.44 2.0 -0.494 29.0 31.0 STIL 0.041 0.149 0.386 16.0 -0.341 7.0 23.0 DHH N/PTCH2 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.006 0.161 0.377 2.0 -0.435 23.0 25.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.111 0.392 0.664 2.0 -0.902 94.0 96.0 determination of left/right symmetry -0.015 0.181 0.44 2.0 -0.494 29.0 31.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.543 47.0 47.0 skeletal system development -0.109 0.387 0.663 2.0 -0.89 94.0 96.0 IHH N/Hhip 0.038 0.052 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.05 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.015 0.181 0.44 2.0 -0.494 29.0 31.0 pancreas development 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.024 0.059 -9999.0 0.0 -0.543 5.0 5.0 PI3K 0.005 0.127 -9999.0 0.0 -0.399 44.0 44.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.144 0.266 -9999.0 0.0 -0.543 158.0 158.0 somite specification -0.015 0.181 0.44 2.0 -0.494 29.0 31.0 SHH Np/Cholesterol/PTCH1 -0.009 0.122 -9999.0 0.0 -0.379 8.0 8.0 SHH Np/Cholesterol/PTCH2 0.024 0.037 -9999.0 0.0 -0.311 5.0 5.0 SHH Np/Cholesterol/Megalin -0.055 0.145 -9999.0 0.0 -0.319 110.0 110.0 SHH 0.011 0.043 -9999.0 0.0 -0.399 5.0 5.0 catabolic process -0.009 0.174 0.462 2.0 -0.359 82.0 84.0 SMO/Vitamin D3 0.01 0.171 0.408 15.0 -0.463 12.0 27.0 SHH Np/Cholesterol/Hhip 0.025 0.038 -9999.0 0.0 -0.311 5.0 5.0 LRP2 -0.119 0.254 -9999.0 0.0 -0.543 136.0 136.0 receptor-mediated endocytosis -0.061 0.195 0.347 8.0 -0.513 37.0 45.0 SHH Np/Cholesterol/BOC -0.038 0.13 -9999.0 0.0 -0.312 87.0 87.0 SHH Np/Cholesterol/CDO 0.02 0.049 -9999.0 0.0 -0.351 7.0 7.0 mesenchymal cell differentiation -0.025 0.038 0.309 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.027 0.158 0.412 16.0 -0.38 8.0 24.0 IHH N/PTCH2 0.038 0.051 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.027 0.045 -9999.0 0.0 -0.543 3.0 3.0 IHH N/PTCH1 -0.0 0.179 0.465 2.0 -0.36 84.0 86.0 Megalin/LRPAP1 -0.071 0.198 -9999.0 0.0 -0.397 137.0 137.0 PTCH2 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.034 -9999.0 0.0 -0.309 5.0 5.0 PTCH1 -0.009 0.174 0.463 2.0 -0.361 82.0 84.0 HHIP 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0