Correlation between copy number variations of arm-level result and selected clinical features
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (Primary solid tumor)
28 January 2016  |  analyses__2016_01_28
Maintainer Information
Citation Information
doi:10.7908/C12N51N2
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2016): Correlation between copy number variations of arm-level result and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C12N51N2
Overview
Introduction

This pipeline computes the correlation between significant arm-level copy number variations (cnvs) and selected clinical features.

Summary

Testing the association between copy number variation 82 arm-level events and 39 clinical features across 295 patients, 15 significant findings detected with Q value < 0.25.

  • 9q gain cnv correlated to 'PREGNANCIES_COUNT_LIVE_BIRTH'.

  • xp gain cnv correlated to 'PREGNANCIES_COUNT_LIVE_BIRTH'.

  • 4p loss cnv correlated to 'NUMBER_OF_LYMPH_NODES' and 'LYMPH_NODES_EXAMINED_HE_COUNT'.

  • 4q loss cnv correlated to 'RADIATION_THERAPY'.

  • 8p loss cnv correlated to 'TOBACCO_SMOKING_YEAR_STOPPED'.

  • 9q loss cnv correlated to 'YEARS_TO_BIRTH'.

  • 10q loss cnv correlated to 'NEOPLASM_HISTOLOGIC_GRADE'.

  • 11p loss cnv correlated to 'YEARS_TO_BIRTH' and 'AGE_AT_DIAGNOSIS'.

  • 11q loss cnv correlated to 'YEARS_TO_BIRTH' and 'AGE_AT_DIAGNOSIS'.

  • 16q loss cnv correlated to 'HISTOLOGICAL_TYPE'.

  • 18q loss cnv correlated to 'HISTOLOGICAL_TYPE'.

  • 19p loss cnv correlated to 'Time to Death'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 82 arm-level events and 39 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 15 significant findings detected.

Clinical
Features 		Time
to
Death 		YEARS
TO
BIRTH 		PATHOLOGY
T
STAGE 		PATHOLOGY
N
STAGE 		PATHOLOGY
M
STAGE 		RADIATION
THERAPY 		HISTOLOGICAL
TYPE 		NUMBER
PACK
YEARS
SMOKED 		NUMBER
OF
LYMPH
NODES 		RACE ETHNICITY WEIGHT
KG
AT
DIAGNOSIS 		TUMOR
STATUS 		NEOPLASM
HISTOLOGIC
GRADE 		TOBACCO
SMOKING
YEAR
STOPPED 		TOBACCO
SMOKING
PACK
YEARS
SMOKED 		TOBACCO
SMOKING
HISTORY 		AGEBEGANSMOKINGINYEARS RADIATION
THERAPY
STATUS 		PREGNANCIES
COUNT
TOTAL 		PREGNANCIES
COUNT
STILLBIRTH 		PREGNANCY
SPONTANEOUS
ABORTION
COUNT 		PREGNANCIES
COUNT
LIVE
BIRTH 		PREGNANCY
THERAPEUTIC
ABORTION
COUNT 		PREGNANCIES
COUNT
ECTOPIC 		POS
LYMPH
NODE
LOCATION 		MENOPAUSE
STATUS 		LYMPHOVASCULAR
INVOLVEMENT 		LYMPH
NODES
EXAMINED
HE
COUNT 		LYMPH
NODES
EXAMINED 		KERATINIZATION
SQUAMOUS
CELL 		INITIAL
PATHOLOGIC
DX
YEAR 		HISTORY
HORMONAL
CONTRACEPTIVES
USE 		HEIGHT
CM
AT
DIAGNOSIS 		CORPUS
INVOLVEMENT 		CHEMO
CONCURRENT
TYPE 		CERVIX
SUV
RESULTS 		AGE
AT
DIAGNOSIS 		CLINICAL
STAGE
nCNV (%) nWild-Type logrank test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Fisher's exact test Wilcoxon-test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Fisher's exact test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test
4p loss 130 (44%) 165 0.379
(0.981) 		0.542
(1.00) 		0.136
(0.799) 		0.00585
(0.513) 		0.525
(1.00) 		0.014
(0.58) 		0.00172
(0.306) 		0.36
(0.98) 		0.0011
(0.246) 		0.518
(1.00) 		0.261
(0.908) 		0.0882
(0.744) 		1
(1.00) 		0.168
(0.846) 		0.368
(0.981) 		0.36
(0.98) 		0.246
(0.906) 		0.805
(1.00) 		0.583
(1.00) 		0.217
(0.887) 		0.278
(0.923) 		0.957
(1.00) 		0.113
(0.774) 		0.186
(0.854) 		0.48
(1.00) 		0.665
(1.00) 		0.659
(1.00) 		0.237
(0.903) 		0.0011
(0.246) 		0.344
(0.977) 		0.307
(0.948) 		0.13
(0.787) 		0.659
(1.00) 		0.501
(1.00) 		0.795
(1.00) 		0.0582
(0.682) 		0.885
(1.00) 		0.543
(1.00) 		0.463
(1.00)
11p loss 100 (34%) 195 0.598
(1.00) 		0.000512
(0.225) 		0.348
(0.978) 		0.86
(1.00) 		0.497
(1.00) 		1
(1.00) 		0.0672
(0.733) 		0.26
(0.907) 		0.853
(1.00) 		0.187
(0.857) 		0.814
(1.00) 		0.863
(1.00) 		0.0318
(0.603) 		0.11
(0.774) 		0.387
(0.981) 		0.26
(0.907) 		0.525
(1.00) 		0.365
(0.981) 		0.551
(1.00) 		0.00611
(0.515) 		0.0382
(0.626) 		0.512
(1.00) 		0.018
(0.58) 		0.386
(0.981) 		0.0341
(0.609) 		0.624
(1.00) 		0.0152
(0.58) 		0.357
(0.98) 		0.853
(1.00) 		0.574
(1.00) 		0.719
(1.00) 		0.29
(0.933) 		0.127
(0.78) 		0.0209
(0.58) 		0.405
(0.983) 		0.196
(0.872) 		0.225
(0.898) 		0.000436
(0.225) 		0.0353
(0.614)
11q loss 115 (39%) 180 0.635
(1.00) 		8.58e-05
(0.217) 		0.553
(1.00) 		0.867
(1.00) 		1
(1.00) 		0.741
(1.00) 		0.167
(0.845) 		0.805
(1.00) 		0.474
(1.00) 		0.174
(0.851) 		0.356
(0.98) 		0.732
(1.00) 		0.0262
(0.58) 		0.754
(1.00) 		0.641
(1.00) 		0.805
(1.00) 		0.455
(1.00) 		0.0516
(0.666) 		1
(1.00) 		0.0275
(0.584) 		0.0531
(0.667) 		0.209
(0.877) 		0.0773
(0.739) 		0.0794
(0.739) 		0.0102
(0.58) 		0.597
(1.00) 		0.00143
(0.269) 		0.389
(0.981) 		0.474
(1.00) 		0.286
(0.929) 		0.861
(1.00) 		0.622
(1.00) 		0.608
(1.00) 		0.19
(0.857) 		0.283
(0.927) 		0.563
(1.00) 		0.225
(0.898) 		0.000136
(0.217) 		0.269
(0.916)
9q gain 50 (17%) 245 0.688
(1.00) 		0.0928
(0.744) 		0.122
(0.774) 		0.127
(0.78) 		1
(1.00) 		1
(1.00) 		0.579
(1.00) 		0.128
(0.781) 		0.168
(0.846) 		0.0895
(0.744) 		0.521
(1.00) 		0.545
(1.00) 		1
(1.00) 		0.527
(1.00) 		0.145
(0.819) 		0.128
(0.781) 		0.832
(1.00) 		0.949
(1.00) 		1
(1.00) 		0.15
(0.827) 		0.983
(1.00) 		0.0512
(0.666) 		0.000817
(0.246) 		0.997
(1.00) 		0.108
(0.77) 		0.757
(1.00) 		0.396
(0.981) 		0.808
(1.00) 		0.168
(0.846) 		0.935
(1.00) 		0.112
(0.774) 		0.535
(1.00) 		0.675
(1.00) 		0.57
(1.00) 		0.363
(0.981) 		0.272
(0.921) 		0.692
(1.00) 		0.124
(0.774) 		0.247
(0.906)
xp gain 40 (14%) 255 0.595
(1.00) 		0.248
(0.906) 		0.116
(0.774) 		0.492
(1.00) 		0.179
(0.853) 		0.513
(1.00) 		0.656
(1.00) 		0.125
(0.774) 		0.647
(1.00) 		0.587
(1.00) 		1
(1.00) 		0.134
(0.796) 		0.437
(1.00) 		0.733
(1.00) 		0.125
(0.774) 		0.125
(0.774) 		0.44
(1.00) 		0.395
(0.981) 		0.298
(0.936) 		0.0077
(0.521) 		0.0397
(0.633) 		0.235
(0.903) 		0.00113
(0.246) 		0.292
(0.933) 		0.816
(1.00) 		0.616
(1.00) 		0.66
(1.00) 		0.608
(1.00) 		0.647
(1.00) 		0.7
(1.00) 		0.497
(1.00) 		0.911
(1.00) 		0.243
(0.906) 		0.16
(0.83) 		0.121
(0.774) 		0.452
(1.00) 		0.268
(0.913) 		0.726
(1.00)
4q loss 95 (32%) 200 0.326
(0.961) 		0.786
(1.00) 		0.0467
(0.65) 		0.0507
(0.666) 		0.295
(0.935) 		0.000851
(0.246) 		0.199
(0.874) 		0.663
(1.00) 		0.0185
(0.58) 		0.476
(1.00) 		0.226
(0.898) 		0.0274
(0.584) 		0.469
(1.00) 		0.00385
(0.456) 		0.42
(0.992) 		0.663
(1.00) 		0.909
(1.00) 		0.405
(0.983) 		0.543
(1.00) 		0.421
(0.992) 		0.687
(1.00) 		0.278
(0.923) 		0.34
(0.972) 		0.181
(0.853) 		0.99
(1.00) 		0.345
(0.977) 		0.883
(1.00) 		0.274
(0.922) 		0.0185
(0.58) 		0.641
(1.00) 		0.856
(1.00) 		0.239
(0.903) 		0.74
(1.00) 		0.935
(1.00) 		0.762
(1.00) 		0.83
(1.00) 		0.157
(0.829) 		0.809
(1.00) 		0.781
(1.00)
8p loss 82 (28%) 213 0.0248
(0.58) 		0.435
(1) 		0.94
(1.00) 		0.588
(1.00) 		0.0611
(0.706) 		0.579
(1.00) 		0.612
(1.00) 		0.517
(1.00) 		0.486
(1.00) 		0.247
(0.906) 		1
(1.00) 		0.82
(1.00) 		0.0525
(0.667) 		0.173
(0.848) 		0.000626
(0.225) 		0.517
(1.00) 		0.604
(1.00) 		0.24
(0.903) 		0.543
(1.00) 		0.923
(1.00) 		0.583
(1.00) 		0.531
(1.00) 		0.558
(1.00) 		0.644
(1.00) 		0.99
(1.00) 		0.698
(1.00) 		0.752
(1.00) 		0.124
(0.774) 		0.486
(1.00) 		0.584
(1.00) 		0.447
(1.00) 		0.501
(1.00) 		0.8
(1.00) 		0.864
(1.00) 		0.775
(1.00) 		0.522
(1.00) 		0.393
(0.981) 		0.397
(0.982) 		0.386
(0.981)
9q loss 48 (16%) 247 0.0962
(0.753) 		0.00115
(0.246) 		0.222
(0.896) 		0.809
(1.00) 		0.407
(0.986) 		1
(1.00) 		0.55
(1.00) 		0.642
(1.00) 		0.931
(1.00) 		0.321
(0.96) 		1
(1.00) 		0.716
(1.00) 		0.0413
(0.633) 		0.916
(1.00) 		0.382
(0.981) 		0.642
(1.00) 		0.282
(0.924) 		0.863
(1.00) 		1
(1.00) 		0.0614
(0.706) 		0.354
(0.98) 		0.696
(1.00) 		0.238
(0.903) 		0.0769
(0.739) 		0.19
(0.857) 		1
(1.00) 		0.0624
(0.708) 		0.64
(1.00) 		0.931
(1.00) 		0.465
(1.00) 		0.155
(0.827) 		0.354
(0.98) 		0.556
(1.00) 		0.318
(0.96) 		1
(1.00) 		1
(1.00) 		0.00137
(0.269) 		0.544
(1.00)
10q loss 73 (25%) 222 0.58
(1.00) 		0.0131
(0.58) 		0.543
(1.00) 		0.0559
(0.678) 		0.686
(1.00) 		1
(1.00) 		0.364
(0.981) 		0.961
(1.00) 		0.0222
(0.58) 		0.0419
(0.634) 		0.801
(1.00) 		0.782
(1.00) 		0.12
(0.774) 		0.00056
(0.225) 		0.681
(1.00) 		0.961
(1.00) 		0.0424
(0.634) 		0.445
(1.00) 		1
(1.00) 		0.149
(0.827) 		0.67
(1.00) 		0.244
(0.906) 		0.0747
(0.739) 		0.77
(1.00) 		0.476
(1.00) 		0.00594
(0.513) 		0.154
(0.827) 		0.0537
(0.67) 		0.0222
(0.58) 		0.575
(1.00) 		0.56
(1.00) 		0.251
(0.906) 		0.807
(1.00) 		0.0968
(0.753) 		1
(1.00) 		0.803
(1.00) 		0.526
(1.00) 		0.0162
(0.58) 		0.568
(1.00)
16q loss 43 (15%) 252 0.556
(1.00) 		0.234
(0.903) 		0.733
(1.00) 		0.0222
(0.58) 		1
(1.00) 		1
(1.00) 		0.00026
(0.225) 		0.382
(0.981) 		0.0921
(0.744) 		0.215
(0.887) 		0.744
(1.00) 		0.689
(1.00) 		0.558
(1.00) 		0.153
(0.827) 		0.846
(1.00) 		0.382
(0.981) 		0.793
(1.00) 		0.423
(0.992) 		1
(1.00) 		0.145
(0.819) 		0.874
(1.00) 		0.864
(1.00) 		0.446
(1.00) 		0.144
(0.816) 		0.149
(0.827) 		0.926
(1.00) 		0.569
(1.00) 		0.634
(1.00) 		0.0921
(0.744) 		0.465
(1.00) 		0.0561
(0.678) 		0.345
(0.977) 		1
(1.00) 		0.366
(0.981) 		0.458
(1.00) 		0.663
(1.00) 		0.185
(0.854) 		0.904
(1.00)
18q loss 73 (25%) 222 0.662
(1.00) 		0.875
(1.00) 		0.619
(1.00) 		0.124
(0.774) 		0.456
(1.00) 		0.849
(1.00) 		0.00034
(0.225) 		0.263
(0.908) 		0.04
(0.633) 		0.987
(1.00) 		0.789
(1.00) 		0.222
(0.896) 		0.345
(0.977) 		0.572
(1.00) 		0.429
(0.996) 		0.263
(0.908) 		0.0385
(0.627) 		0.475
(1.00) 		1
(1.00) 		0.0966
(0.753) 		0.166
(0.844) 		0.845
(1.00) 		0.131
(0.79) 		0.925
(1.00) 		0.864
(1.00) 		0.597
(1.00) 		0.595
(1.00) 		0.101
(0.759) 		0.04
(0.633) 		0.364
(0.981) 		1
(1.00) 		0.0364
(0.615) 		0.264
(0.909) 		0.645
(1.00) 		0.0113
(0.58) 		0.0821
(0.744) 		0.824
(1.00) 		0.0823
(0.744)
19p loss 60 (20%) 235 0.000634
(0.225) 		0.354
(0.98) 		0.266
(0.909) 		0.199
(0.874) 		1
(1.00) 		1
(1.00) 		0.702
(1.00) 		0.224
(0.897) 		0.181
(0.853) 		0.336
(0.97) 		0.258
(0.906) 		0.741
(1.00) 		0.028
(0.584) 		0.198
(0.874) 		0.428
(0.995) 		0.224
(0.897) 		0.826
(1.00) 		0.122
(0.774) 		1
(1.00) 		0.702
(1.00) 		0.23
(0.903) 		0.971
(1.00) 		0.713
(1.00) 		0.959
(1.00) 		0.351
(0.98) 		0.926
(1.00) 		0.0322
(0.603) 		0.389
(0.981) 		0.181
(0.853) 		0.864
(1.00) 		1
(1.00) 		0.234
(0.903) 		0.558
(1.00) 		0.0366
(0.615) 		0.331
(0.966) 		0.256
(0.906) 		0.282
(0.924) 		0.386
(0.981) 		0.988
(1.00)
1p gain 92 (31%) 203 0.789
(1.00) 		0.0206
(0.58) 		0.125
(0.774) 		0.599
(1.00) 		1
(1.00) 		0.719
(1.00) 		0.0678
(0.733) 		0.321
(0.96) 		0.094
(0.744) 		0.0948
(0.747) 		1
(1.00) 		0.491
(1.00) 		0.773
(1.00) 		0.124
(0.774) 		0.869
(1.00) 		0.321
(0.96) 		0.472
(1.00) 		0.706
(1.00) 		1
(1.00) 		0.0884
(0.744) 		0.327
(0.961) 		0.917
(1.00) 		0.185
(0.854) 		0.626
(1.00) 		0.465
(1.00) 		0.477
(1.00) 		0.0285
(0.584) 		0.593
(1.00) 		0.094
(0.744) 		0.671
(1.00) 		1
(1.00) 		0.594
(1.00) 		0.105
(0.77) 		0.0279
(0.584) 		0.405
(0.983) 		1
(1.00) 		0.0606
(0.706) 		0.0174
(0.58) 		0.208
(0.877)
1q gain 141 (48%) 154 0.438
(1.00) 		0.291
(0.933) 		0.0832
(0.744) 		1
(1.00) 		0.323
(0.961) 		1
(1.00) 		0.128
(0.781) 		0.546
(1.00) 		0.646
(1.00) 		0.0132
(0.58) 		0.825
(1.00) 		0.186
(0.854) 		0.893
(1.00) 		0.307
(0.947) 		0.85
(1.00) 		0.546
(1.00) 		0.719
(1.00) 		0.993
(1.00) 		1
(1.00) 		0.393
(0.981) 		0.256
(0.906) 		0.293
(0.933) 		0.624
(1.00) 		0.918
(1.00) 		0.116
(0.774) 		0.218
(0.887) 		0.312
(0.955) 		0.405
(0.983) 		0.646
(1.00) 		0.819
(1.00) 		0.395
(0.981) 		0.961
(1.00) 		0.415
(0.989) 		0.0307
(0.603) 		0.8
(1.00) 		0.219
(0.888) 		0.291
(0.933) 		0.237
(0.903) 		0.745
(1.00)
2p gain 65 (22%) 230 0.704
(1.00) 		0.325
(0.961) 		0.62
(1.00) 		1
(1.00) 		0.44
(1.00) 		0.121
(0.774) 		0.787
(1.00) 		0.171
(0.848) 		1
(1.00) 		0.541
(1.00) 		1
(1.00) 		0.0229
(0.58) 		0.101
(0.759) 		0.48
(1.00) 		0.284
(0.927) 		0.171
(0.848) 		0.667
(1.00) 		0.595
(1.00) 		1
(1.00) 		0.58
(1.00) 		0.245
(0.906) 		0.565
(1.00) 		0.356
(0.98) 		0.569
(1.00) 		0.109
(0.77) 		0.816
(1.00) 		0.96
(1.00) 		0.532
(1.00) 		1
(1.00) 		0.88
(1.00) 		0.826
(1.00) 		0.62
(1.00) 		0.62
(1.00) 		0.673
(1.00) 		0.107
(0.77) 		0.365
(0.981) 		0.299
(0.936) 		0.34
(0.972)
2q gain 38 (13%) 257 0.539
(1.00) 		0.701
(1.00) 		0.587
(1.00) 		0.136
(0.799) 		0.624
(1.00) 		0.0863
(0.744) 		0.682
(1.00) 		0.473
(1.00) 		0.0937
(0.744) 		1
(1.00) 		1
(1.00) 		0.0726
(0.739) 		0.317
(0.96) 		0.426
(0.993) 		0.0529
(0.667) 		0.473
(1.00) 		0.947
(1.00) 		0.434
(1) 		1
(1.00) 		0.0542
(0.67) 		0.377
(0.981) 		0.605
(1.00) 		0.151
(0.827) 		0.57
(1.00) 		0.0852
(0.744) 		0.418
(0.992) 		0.945
(1.00) 		0.0769
(0.739) 		0.0937
(0.744) 		0.687
(1.00) 		0.796
(1.00) 		0.49
(1.00) 		0.428
(0.995) 		0.55
(1.00) 		0.107
(0.77) 		0.401
(0.983) 		0.625
(1.00) 		0.71
(1.00)
3p gain 78 (26%) 217 0.00236
(0.354) 		0.495
(1.00) 		0.389
(0.981) 		1
(1.00) 		0.258
(0.906) 		0.577
(1.00) 		0.943
(1.00) 		0.155
(0.827) 		0.51
(1.00) 		0.568
(1.00) 		0.789
(1.00) 		0.254
(0.906) 		0.00736
(0.521) 		0.0921
(0.744) 		0.989
(1.00) 		0.155
(0.827) 		0.929
(1.00) 		0.476
(1.00) 		0.53
(1.00) 		0.521
(1.00) 		0.612
(1.00) 		0.777
(1.00) 		0.323
(0.961) 		0.575
(1.00) 		0.55
(1.00) 		0.402
(0.983) 		0.297
(0.936) 		0.843
(1.00) 		0.51
(1.00) 		0.526
(1.00) 		0.844
(1.00) 		0.0561
(0.678) 		1
(1.00) 		0.965
(1.00) 		0.537
(1.00) 		0.373
(0.981) 		0.209
(0.877) 		0.536
(1.00) 		0.748
(1.00)
3q gain 176 (60%) 119 0.271
(0.919) 		0.817
(1.00) 		0.498
(1.00) 		0.0218
(0.58) 		1
(1.00) 		0.317
(0.96) 		0.00847
(0.521) 		0.17
(0.848) 		0.0173
(0.58) 		0.234
(0.903) 		0.374
(0.981) 		0.0676
(0.733) 		0.41
(0.987) 		0.702
(1.00) 		0.807
(1.00) 		0.17
(0.848) 		0.837
(1.00) 		0.426
(0.993) 		1
(1.00) 		0.352
(0.98) 		0.617
(1.00) 		0.907
(1.00) 		0.67
(1.00) 		0.488
(1.00) 		0.928
(1.00) 		0.253
(0.906) 		0.493
(1.00) 		0.241
(0.904) 		0.0173
(0.58) 		0.965
(1.00) 		0.733
(1.00) 		0.221
(0.894) 		0.576
(1.00) 		0.654
(1.00) 		0.796
(1.00) 		0.0156
(0.58) 		0.155
(0.827) 		0.899
(1.00) 		0.279
(0.923)
4p gain 11 (4%) 284 0.93
(1.00) 		0.349
(0.978) 		0.679
(1.00) 		0.677
(1.00) 		1
(1.00) 		1
(1.00) 		0.451
(1.00) 		0.605
(1.00) 		0.338
(0.972) 		0.241
(0.903) 		1
(1.00) 		0.967
(1.00) 		1
(1.00) 		0.39
(0.981) 		0.605
(1.00) 		0.66
(1.00) 		1
(1.00) 		0.44
(1.00) 		0.686
(1.00) 		0.216
(0.887) 		0.263
(0.908) 		0.724
(1.00) 		0.552
(1.00) 		0.882
(1.00) 		1
(1.00) 		0.338
(0.972) 		0.494
(1.00) 		1
(1.00) 		0.222
(0.896) 		1
(1.00) 		0.8
(1.00) 		1
(1.00) 		0.185
(0.854) 		0.354
(0.98) 		0.551
(1.00)
4q gain 14 (5%) 281 0.633
(1.00) 		0.778
(1.00) 		0.756
(1.00) 		0.737
(1.00) 		0.419
(0.992) 		1
(1.00) 		0.388
(0.981) 		0.581
(1.00) 		0.712
(1.00) 		0.395
(0.981) 		1
(1.00) 		0.695
(1.00) 		1
(1.00) 		0.374
(0.981) 		0.581
(1.00) 		0.659
(1.00) 		0.809
(1.00) 		0.791
(1.00) 		0.686
(1.00) 		0.216
(0.887) 		0.825
(1.00) 		0.724
(1.00) 		0.552
(1.00) 		0.741
(1.00) 		0.437
(1.00) 		0.719
(1.00) 		0.712
(1.00) 		0.956
(1.00) 		0.107
(0.77) 		0.454
(1.00) 		0.68
(1.00) 		0.603
(1.00) 		0.589
(1.00) 		1
(1.00) 		0.765
(1.00) 		0.752
(1.00)
5p gain 115 (39%) 180 0.81
(1.00) 		0.859
(1.00) 		0.0765
(0.739) 		0.867
(1.00) 		0.0467
(0.65) 		0.181
(0.853) 		0.0181
(0.58) 		0.079
(0.739) 		0.849
(1.00) 		0.377
(0.981) 		0.063
(0.709) 		0.988
(1.00) 		0.678
(1.00) 		0.0914
(0.744) 		0.813
(1.00) 		0.079
(0.739) 		0.656
(1.00) 		0.831
(1.00) 		0.53
(1.00) 		0.0784
(0.739) 		0.386
(0.981) 		0.807
(1.00) 		0.0157
(0.58) 		0.123
(0.774) 		0.285
(0.929) 		0.771
(1.00) 		0.663
(1.00) 		1
(1.00) 		0.849
(1.00) 		0.0419
(0.634) 		0.299
(0.936) 		0.497
(1.00) 		0.967
(1.00) 		0.86
(1.00) 		0.777
(1.00) 		0.056
(0.678) 		0.665
(1.00) 		0.747
(1.00) 		0.0104
(0.58)
5q gain 48 (16%) 247 0.835
(1.00) 		0.383
(0.981) 		0.0348
(0.612) 		1
(1.00) 		0.208
(0.877) 		0.371
(0.981) 		0.523
(1.00) 		0.334
(0.969) 		0.38
(0.981) 		0.578
(1.00) 		1
(1.00) 		0.884
(1.00) 		0.853
(1.00) 		0.759
(1.00) 		0.834
(1.00) 		0.334
(0.969) 		0.398
(0.983) 		0.728
(1.00) 		1
(1.00) 		0.239
(0.903) 		0.874
(1.00) 		0.436
(1.00) 		0.169
(0.848) 		0.455
(1.00) 		0.149
(0.827) 		0.698
(1.00) 		0.0629
(0.709) 		0.62
(1.00) 		0.38
(0.981) 		0.837
(1.00) 		0.637
(1.00) 		0.134
(0.795) 		0.596
(1.00) 		0.823
(1.00) 		0.12
(0.774) 		1
(1.00) 		0.571
(1.00) 		0.414
(0.988) 		0.82
(1.00)
6p gain 52 (18%) 243 0.291
(0.933) 		0.247
(0.906) 		0.934
(1.00) 		0.201
(0.874) 		0.677
(1.00) 		0.834
(1.00) 		0.703
(1.00) 		0.293
(0.933) 		0.32
(0.96) 		0.883
(1.00) 		1
(1.00) 		0.603
(1.00) 		0.122
(0.774) 		0.0257
(0.58) 		0.876
(1.00) 		0.293
(0.933) 		0.61
(1.00) 		0.523
(1.00) 		0.53
(1.00) 		0.54
(1.00) 		0.843
(1.00) 		0.405
(0.983) 		0.257
(0.906) 		0.968
(1.00) 		0.602
(1.00) 		0.886
(1.00) 		0.51
(1.00) 		0.375
(0.981) 		0.32
(0.96) 		0.729
(1.00) 		1
(1.00) 		0.118
(0.774) 		0.138
(0.799) 		0.393
(0.981) 		0.294
(0.933) 		0.23
(0.903) 		0.562
(1.00) 		0.268
(0.913) 		0.138
(0.799)
6q gain 35 (12%) 260 0.0266
(0.58) 		0.449
(1.00) 		0.148
(0.827) 		0.618
(1.00) 		1
(1.00) 		1
(1.00) 		0.342
(0.977) 		0.264
(0.908) 		0.916
(1.00) 		0.98
(1.00) 		0.302
(0.937) 		0.244
(0.906) 		0.0251
(0.58) 		0.118
(0.774) 		0.44
(1.00) 		0.264
(0.908) 		0.57
(1.00) 		0.41
(0.987) 		0.551
(1.00) 		0.176
(0.853) 		0.983
(1.00) 		0.782
(1.00) 		0.281
(0.924) 		0.919
(1.00) 		0.411
(0.987) 		0.875
(1.00) 		0.973
(1.00) 		0.789
(1.00) 		0.916
(1.00) 		0.449
(1.00) 		0.583
(1.00) 		0.366
(0.981) 		0.351
(0.98) 		0.614
(1.00) 		0.209
(0.877) 		0.371
(0.981) 		0.958
(1.00) 		0.475
(1.00) 		0.444
(1.00)
7p gain 37 (13%) 258 0.731
(1.00) 		0.15
(0.827) 		0.00286
(0.381) 		1
(1.00) 		0.0508
(0.666) 		0.156
(0.827) 		0.918
(1.00) 		0.0258
(0.58) 		0.25
(0.906) 		0.76
(1.00) 		0.486
(1.00) 		0.907
(1.00) 		0.163
(0.839) 		0.555
(1.00) 		0.834
(1.00) 		0.0258
(0.58) 		0.634
(1.00) 		0.0757
(0.739) 		0.382
(0.981) 		0.117
(0.774) 		0.69
(1.00) 		0.689
(1.00) 		0.0364
(0.615) 		0.536
(1.00) 		0.763
(1.00) 		0.107
(0.77) 		0.359
(0.98) 		0.13
(0.787) 		0.25
(0.906) 		0.903
(1.00) 		0.795
(1.00) 		0.528
(1.00) 		0.912
(1.00) 		0.466
(1.00) 		0.667
(1.00) 		1
(1.00) 		0.164
(0.839) 		0.0243
(0.58)
7q gain 38 (13%) 257 0.668
(1.00) 		0.051
(0.666) 		0.00261
(0.363) 		0.594
(1.00) 		0.08
(0.739) 		0.156
(0.827) 		0.704
(1.00) 		0.16
(0.829) 		0.552
(1.00) 		0.498
(1.00) 		0.719
(1.00) 		0.684
(1.00) 		0.842
(1.00) 		0.571
(1.00) 		0.253
(0.906) 		0.16
(0.829) 		0.442
(1.00) 		0.256
(0.906) 		0.53
(1.00) 		0.671
(1.00) 		0.816
(1.00) 		0.436
(1.00) 		0.25
(0.906) 		0.321
(0.96) 		0.166
(0.844) 		0.605
(1.00) 		0.447
(1.00) 		0.368
(0.981) 		0.552
(1.00) 		0.843
(1.00) 		0.798
(1.00) 		0.0692
(0.736) 		1
(1.00) 		0.981
(1.00) 		1
(1.00) 		1
(1.00) 		0.057
(0.678) 		0.527
(1.00)
8p gain 53 (18%) 242 0.461
(1.00) 		0.157
(0.829) 		0.0126
(0.58) 		0.548
(1.00) 		0.0237
(0.58) 		0.0372
(0.619) 		0.251
(0.906) 		0.3
(0.936) 		0.619
(1.00) 		0.548
(1.00) 		1
(1.00) 		0.854
(1.00) 		0.717
(1.00) 		0.901
(1.00) 		0.617
(1.00) 		0.3
(0.936) 		0.485
(1.00) 		0.482
(1.00) 		1
(1.00) 		0.214
(0.887) 		0.983
(1.00) 		0.785
(1.00) 		0.483
(1.00) 		0.08
(0.739) 		0.473
(1.00) 		0.387
(0.981) 		0.384
(0.981) 		0.267
(0.91) 		0.619
(1.00) 		0.216
(0.887) 		0.833
(1.00) 		0.399
(0.983) 		0.0869
(0.744) 		0.404
(0.983) 		1
(1.00) 		1
(1.00) 		0.61
(1.00) 		0.139
(0.801) 		0.895
(1.00)
8q gain 91 (31%) 204 0.922
(1.00) 		0.113
(0.774) 		0.00201
(0.338) 		0.604
(1.00) 		0.0741
(0.739) 		0.17
(0.848) 		0.0124
(0.58) 		0.759
(1.00) 		0.871
(1.00) 		0.571
(1.00) 		0.81
(1.00) 		0.584
(1.00) 		0.459
(1.00) 		0.913
(1.00) 		0.336
(0.97) 		0.759
(1.00) 		0.376
(0.981) 		0.792
(1.00) 		0.53
(1.00) 		0.768
(1.00) 		0.627
(1.00) 		0.249
(0.906) 		0.767
(1.00) 		0.181
(0.853) 		0.53
(1.00) 		0.403
(0.983) 		0.774
(1.00) 		0.451
(1.00) 		0.871
(1.00) 		0.23
(0.903) 		0.592
(1.00) 		0.107
(0.77) 		0.12
(0.774) 		0.849
(1.00) 		1
(1.00) 		0.545
(1.00) 		0.961
(1.00) 		0.108
(0.77) 		0.44
(1.00)
9p gain 51 (17%) 244 0.594
(1.00) 		0.134
(0.795) 		0.114
(0.774) 		0.127
(0.78) 		1
(1.00) 		0.681
(1.00) 		0.948
(1.00) 		0.18
(0.853) 		0.159
(0.829) 		0.117
(0.774) 		0.507
(1.00) 		0.743
(1.00) 		0.465
(1.00) 		0.685
(1.00) 		0.171
(0.848) 		0.18
(0.853) 		0.74
(1.00) 		0.58
(1.00) 		1
(1.00) 		0.747
(1.00) 		0.888
(1.00) 		0.0977
(0.754) 		0.0341
(0.609) 		0.47
(1.00) 		0.0865
(0.744) 		0.649
(1.00) 		0.527
(1.00) 		0.818
(1.00) 		0.159
(0.829) 		0.394
(0.981) 		0.0985
(0.756) 		0.33
(0.965) 		0.808
(1.00) 		0.925
(1.00) 		0.21
(0.877) 		0.246
(0.906) 		0.85
(1.00) 		0.121
(0.774) 		0.299
(0.936)
10p gain 25 (8%) 270 0.386
(0.981) 		0.748
(1.00) 		0.0772
(0.739) 		0.0892
(0.744) 		1
(1.00) 		0.78
(1.00) 		0.659
(1.00) 		0.721
(1.00) 		0.0325
(0.603) 		0.937
(1.00) 		0.471
(1.00) 		0.195
(0.868) 		0.805
(1.00) 		0.84
(1.00) 		0.39
(0.981) 		0.721
(1.00) 		0.0515
(0.666) 		0.0429
(0.636) 		1
(1.00) 		0.915
(1.00) 		0.515
(1.00) 		0.91
(1.00) 		0.414
(0.988) 		0.423
(0.992) 		0.271
(0.919) 		0.872
(1.00) 		0.954
(1.00) 		0.368
(0.981) 		0.0325
(0.603) 		0.691
(1.00) 		0.144
(0.816) 		0.207
(0.877) 		0.651
(1.00) 		0.361
(0.981) 		0.688
(1.00) 		0.383
(0.981) 		0.775
(1.00) 		0.768
(1.00)
10q gain 17 (6%) 278 0.959
(1.00) 		0.889
(1.00) 		0.218
(0.887) 		0.19
(0.857) 		1
(1.00) 		0.51
(1.00) 		0.468
(1.00) 		0.184
(0.854) 		0.256
(0.906) 		0.932
(1.00) 		0.172
(0.848) 		0.246
(0.906) 		0.763
(1.00) 		0.532
(1.00) 		0.633
(1.00) 		0.184
(0.854) 		0.133
(0.795) 		0.352
(0.98) 		1
(1.00) 		0.68
(1.00) 		0.589
(1.00) 		0.697
(1.00) 		0.435
(1) 		0.613
(1.00) 		0.132
(0.794) 		0.805
(1.00) 		0.661
(1.00) 		1
(1.00) 		0.256
(0.906) 		0.851
(1.00) 		0.724
(1.00) 		0.37
(0.981) 		0.27
(0.917) 		0.0518
(0.666) 		1
(1.00) 		1
(1.00) 		0.871
(1.00) 		0.763
(1.00)
11p gain 9 (3%) 286 0.977
(1.00) 		0.116
(0.774) 		0.177
(0.853) 		0.639
(1.00) 		0.302
(0.937) 		1
(1.00) 		0.521
(1.00) 		0.204
(0.877) 		1
(1.00) 		0.413
(0.988) 		0.209
(0.877) 		0.691
(1.00) 		0.743
(1.00) 		0.978
(1.00) 		1
(1.00) 		0.421
(0.992) 		0.766
(1.00) 		0.967
(1.00) 		0.572
(1.00) 		0.183
(0.854) 		0.677
(1.00) 		0.204
(0.877) 		0.754
(1.00) 		1
(1.00) 		0.496
(1.00) 		0.0406
(0.633) 		0.741
(1.00) 		1
(1.00) 		0.0832
(0.744) 		0.112
(0.774) 		0.504
(1.00)
11q gain 8 (3%) 287 0.518
(1.00) 		0.326
(0.961) 		0.659
(1.00) 		0.369
(0.981) 		0.302
(0.937) 		1
(1.00) 		0.468
(1.00) 		0.033
(0.603) 		0.78
(1.00) 		0.487
(1.00) 		0.693
(1.00) 		0.677
(1.00) 		0.0349
(0.612) 		0.648
(1.00) 		1
(1.00) 		0.332
(0.969) 		0.789
(1.00) 		0.496
(1.00) 		0.572
(1.00) 		0.201
(0.874) 		1
(1.00) 		0.033
(0.603) 		0.347
(0.978) 		1
(1.00) 		0.252
(0.906) 		0.792
(1.00) 		1
(1.00) 		0.106
(0.77) 		0.317
(0.96) 		0.591
(1.00)
12p gain 53 (18%) 242 0.849
(1.00) 		0.0794
(0.739) 		0.136
(0.799) 		1
(1.00) 		0.117
(0.774) 		0.53
(1.00) 		0.941
(1.00) 		0.023
(0.58) 		0.845
(1.00) 		0.715
(1.00) 		0.771
(1.00) 		0.398
(0.983) 		0.861
(1.00) 		0.493
(1.00) 		0.792
(1.00) 		0.023
(0.58) 		0.39
(0.981) 		0.486
(1.00) 		0.551
(1.00) 		0.0407
(0.633) 		0.888
(1.00) 		0.676
(1.00) 		0.0652
(0.72) 		0.404
(0.983) 		0.198
(0.874) 		0.896
(1.00) 		0.642
(1.00) 		0.524
(1.00) 		0.845
(1.00) 		0.358
(0.98) 		0.0294
(0.598) 		0.73
(1.00) 		0.69
(1.00) 		0.858
(1.00) 		1
(1.00) 		1
(1.00) 		0.692
(1.00) 		0.0916
(0.744) 		0.434
(1)
12q gain 50 (17%) 245 0.796
(1.00) 		0.0938
(0.744) 		0.345
(0.977) 		0.688
(1.00) 		0.407
(0.986) 		1
(1.00) 		0.84
(1.00) 		0.157
(0.829) 		0.979
(1.00) 		0.767
(1.00) 		0.763
(1.00) 		0.238
(0.903) 		0.591
(1.00) 		0.0398
(0.633) 		0.684
(1.00) 		0.157
(0.829) 		0.233
(0.903) 		0.443
(1.00) 		0.536
(1.00) 		0.0109
(0.58) 		0.983
(1.00) 		0.938
(1.00) 		0.0243
(0.58) 		0.709
(1.00) 		0.0208
(0.58) 		1
(1.00) 		0.327
(0.961) 		1
(1.00) 		0.979
(1.00) 		0.973
(1.00) 		0.088
(0.744) 		0.946
(1.00) 		0.745
(1.00) 		0.549
(1.00) 		0.51
(1.00) 		0.732
(1.00) 		0.225
(0.898) 		0.109
(0.77) 		0.527
(1.00)
13q gain 25 (8%) 270 0.0252
(0.58) 		0.744
(1.00) 		0.624
(1.00) 		0.782
(1.00) 		0.599
(1.00) 		0.568
(1.00) 		0.0543
(0.67) 		0.624
(1.00) 		0.587
(1.00) 		0.916
(1.00) 		0.227
(0.902) 		0.617
(1.00) 		0.215
(0.887) 		0.894
(1.00) 		0.624
(1.00) 		0.0429
(0.636) 		0.312
(0.955) 		1
(1.00) 		0.635
(1.00) 		0.453
(1.00) 		0.451
(1.00) 		0.929
(1.00) 		0.229
(0.903) 		1
(1.00) 		1
(1.00) 		0.96
(1.00) 		1
(1.00) 		0.587
(1.00) 		0.198
(0.874) 		1
(1.00) 		0.395
(0.981) 		0.552
(1.00) 		0.727
(1.00) 		0.351
(0.98) 		0.133
(0.795) 		0.77
(1.00) 		0.258
(0.906)
14q gain 47 (16%) 248 0.811
(1.00) 		0.572
(1.00) 		0.333
(0.969) 		0.821
(1.00) 		1
(1.00) 		0.823
(1.00) 		0.724
(1.00) 		0.173
(0.848) 		0.383
(0.981) 		0.568
(1.00) 		0.567
(1.00) 		0.125
(0.774) 		0.467
(1.00) 		0.652
(1.00) 		0.343
(0.977) 		0.173
(0.848) 		0.786
(1.00) 		0.933
(1.00) 		1
(1.00) 		0.0617
(0.706) 		0.277
(0.923) 		0.367
(0.981) 		0.104
(0.77) 		0.123
(0.774) 		0.411
(0.987) 		0.872
(1.00) 		0.405
(0.983) 		1
(1.00) 		0.383
(0.981) 		0.781
(1.00) 		0.49
(1.00) 		0.279
(0.923) 		0.0452
(0.649) 		0.974
(1.00) 		0.734
(1.00) 		0.715
(1.00) 		0.95
(1.00) 		0.534
(1.00) 		0.758
(1.00)
15q gain 52 (18%) 243 0.955
(1.00) 		0.0581
(0.682) 		0.0445
(0.645) 		0.832
(1.00) 		0.205
(0.877) 		0.0841
(0.744) 		0.0507
(0.666) 		0.119
(0.774) 		0.872
(1.00) 		0.292
(0.933) 		0.776
(1.00) 		0.518
(1.00) 		0.479
(1.00) 		0.375
(0.981) 		0.291
(0.933) 		0.119
(0.774) 		0.986
(1.00) 		0.865
(1.00) 		1
(1.00) 		0.057
(0.678) 		0.461
(1.00) 		0.543
(1.00) 		0.123
(0.774) 		0.832
(1.00) 		0.734
(1.00) 		0.785
(1.00) 		0.303
(0.939) 		0.83
(1.00) 		0.872
(1.00) 		0.926
(1.00) 		0.64
(1.00) 		0.729
(1.00) 		0.485
(1.00) 		0.837
(1.00) 		1
(1.00) 		1
(1.00) 		0.0505
(0.666) 		0.276
(0.923)
16p gain 45 (15%) 250 0.964
(1.00) 		0.863
(1.00) 		0.204
(0.877) 		0.277
(0.923) 		0.686
(1.00) 		0.493
(1.00) 		0.96
(1.00) 		0.873
(1.00) 		0.0698
(0.736) 		0.397
(0.982) 		0.538
(1.00) 		0.511
(1.00) 		0.447
(1.00) 		0.624
(1.00) 		0.107
(0.77) 		0.873
(1.00) 		0.946
(1.00) 		0.906
(1.00) 		1
(1.00) 		0.023
(0.58) 		0.93
(1.00) 		0.391
(0.981) 		0.187
(0.857) 		0.874
(1.00) 		0.00706
(0.521) 		0.872
(1.00) 		0.809
(1.00) 		1
(1.00) 		0.0698
(0.736) 		0.567
(1.00) 		0.175
(0.852) 		0.53
(1.00) 		0.531
(1.00) 		0.915
(1.00) 		0.24
(0.903) 		0.422
(0.992) 		0.911
(1.00) 		0.716
(1.00)
16q gain 40 (14%) 255 0.635
(1.00) 		0.825
(1.00) 		0.101
(0.759) 		0.647
(1.00) 		0.208
(0.877) 		0.639
(1.00) 		0.795
(1.00) 		0.819
(1.00) 		0.28
(0.923) 		0.293
(0.933) 		1
(1.00) 		0.316
(0.96) 		0.229
(0.903) 		0.356
(0.98) 		0.107
(0.77) 		0.819
(1.00) 		0.987
(1.00) 		0.613
(1.00) 		1
(1.00) 		0.0172
(0.58) 		0.754
(1.00) 		0.434
(1) 		0.0373
(0.619) 		0.914
(1.00) 		0.0267
(0.58) 		0.888
(1.00) 		0.796
(1.00) 		0.625
(1.00) 		0.28
(0.923) 		0.354
(0.98) 		0.249
(0.906) 		0.479
(1.00) 		1
(1.00) 		0.698
(1.00) 		1
(1.00) 		0.371
(0.981) 		0.783
(1.00) 		0.0799
(0.739)
17p gain 22 (7%) 273 0.539
(1.00) 		0.18
(0.853) 		0.00233
(0.354) 		0.173
(0.848) 		0.235
(0.903) 		0.0678
(0.733) 		0.768
(1.00) 		0.0776
(0.739) 		0.0439
(0.641) 		0.605
(1.00) 		0.357
(0.98) 		0.593
(1.00) 		0.453
(1.00) 		0.537
(1.00) 		0.304
(0.941) 		0.0776
(0.739) 		0.864
(1.00) 		0.1
(0.759) 		1
(1.00) 		0.0113
(0.58) 		0.515
(1.00) 		0.468
(1.00) 		0.21
(0.878) 		0.11
(0.774) 		0.1
(0.759) 		0.516
(1.00) 		0.288
(0.933) 		0.495
(1.00) 		0.0439
(0.641) 		0.168
(0.846) 		0.452
(1.00) 		0.99
(1.00) 		0.649
(1.00) 		0.421
(0.992) 		0.615
(1.00) 		1
(1.00) 		0.194
(0.867) 		0.152
(0.827)
17q gain 43 (15%) 252 0.676
(1.00) 		0.411
(0.987) 		0.0283
(0.584) 		0.812
(1.00) 		1
(1.00) 		0.82
(1.00) 		0.178
(0.853) 		0.0477
(0.652) 		0.274
(0.922) 		0.713
(1.00) 		0.33
(0.966) 		0.321
(0.96) 		1
(1.00) 		0.0177
(0.58) 		0.258
(0.906) 		0.0477
(0.652) 		0.0824
(0.744) 		0.466
(1.00) 		1
(1.00) 		0.00734
(0.521) 		0.377
(0.981) 		0.121
(0.774) 		0.0573
(0.679) 		0.243
(0.906) 		0.119
(0.774) 		0.715
(1.00) 		0.685
(1.00) 		0.473
(1.00) 		0.274
(0.922) 		0.522
(1.00) 		0.795
(1.00) 		0.48
(1.00) 		0.887
(1.00) 		0.0492
(0.661) 		0.294
(0.933) 		1
(1.00) 		0.396
(0.981) 		0.44
(1.00) 		0.113
(0.774)
18p gain 49 (17%) 246 0.355
(0.98) 		0.0178
(0.58) 		0.0462
(0.65) 		0.179
(0.853) 		1
(1.00) 		0.218
(0.887) 		0.0935
(0.744) 		0.84
(1.00) 		0.314
(0.958) 		0.97
(1.00) 		0.352
(0.98) 		0.124
(0.774) 		1
(1.00) 		0.105
(0.77) 		0.708
(1.00) 		0.84
(1.00) 		0.266
(0.909) 		0.391
(0.981) 		1
(1.00) 		0.0874
(0.744) 		0.178
(0.853) 		0.155
(0.827) 		0.0259
(0.58) 		0.751
(1.00) 		0.52
(1.00) 		0.325
(0.961) 		0.842
(1.00) 		1
(1.00) 		0.314
(0.958) 		0.569
(1.00) 		1
(1.00) 		0.152
(0.827) 		0.364
(0.981) 		0.523
(1.00) 		0.709
(1.00) 		0.731
(1.00) 		0.61
(1.00) 		0.021
(0.58) 		0.327
(0.961)
18q gain 32 (11%) 263 0.872
(1.00) 		0.0367
(0.615) 		0.0192
(0.58) 		0.797
(1.00) 		1
(1.00) 		0.316
(0.96) 		0.215
(0.887) 		0.747
(1.00) 		0.99
(1.00) 		0.621
(1.00) 		0.263
(0.908) 		0.194
(0.868) 		0.819
(1.00) 		0.152
(0.827) 		0.833
(1.00) 		0.747
(1.00) 		0.0532
(0.667) 		0.274
(0.922) 		1
(1.00) 		0.164
(0.841) 		0.553
(1.00) 		0.26
(0.908) 		0.101
(0.759) 		0.954
(1.00) 		0.839
(1.00) 		0.26
(0.907) 		0.718
(1.00) 		0.777
(1.00) 		0.99
(1.00) 		0.675
(1.00) 		0.798
(1.00) 		0.21
(0.877) 		1
(1.00) 		0.565
(1.00) 		0.639
(1.00) 		1
(1.00) 		0.61
(1.00) 		0.0414
(0.633) 		0.509
(1.00)
19p gain 45 (15%) 250 0.285
(0.929) 		0.627
(1.00) 		0.155
(0.827) 		0.124
(0.774) 		1
(1.00) 		0.276
(0.923) 		0.853
(1.00) 		0.293
(0.933) 		0.0979
(0.754) 		0.608
(1.00) 		0.209
(0.877) 		0.93
(1.00) 		0.853
(1.00) 		0.817
(1.00) 		0.498
(1.00) 		0.293
(0.933) 		0.349
(0.978) 		0.858
(1.00) 		1
(1.00) 		0.152
(0.827) 		0.874
(1.00) 		0.192
(0.862) 		0.0852
(0.744) 		0.39
(0.981) 		0.573
(1.00) 		0.699
(1.00) 		1
(1.00) 		0.106
(0.77) 		0.0979
(0.754) 		0.0909
(0.744) 		0.0276
(0.584) 		0.554
(1.00) 		1
(1.00) 		0.858
(1.00) 		0.12
(0.774) 		1
(1.00) 		0.571
(1.00) 		0.568
(1.00) 		0.323
(0.961)
19q gain 72 (24%) 223 0.705
(1.00) 		0.275
(0.923) 		0.0303
(0.602) 		0.574
(1.00) 		0.114
(0.774) 		0.44
(1.00) 		0.259
(0.907) 		0.17
(0.848) 		0.689
(1.00) 		0.574
(1.00) 		0.0177
(0.58) 		0.682
(1.00) 		1
(1.00) 		0.586
(1.00) 		0.135
(0.798) 		0.17
(0.848) 		0.866
(1.00) 		0.651
(1.00) 		0.543
(1.00) 		0.0256
(0.58) 		0.54
(1.00) 		0.175
(0.852) 		0.00351
(0.44) 		0.44
(1.00) 		0.233
(0.903) 		0.792
(1.00) 		0.701
(1.00) 		0.239
(0.903) 		0.689
(1.00) 		0.498
(1.00) 		0.0806
(0.739) 		0.217
(0.887) 		0.527
(1.00) 		0.251
(0.906) 		0.755
(1.00) 		1
(1.00) 		0.753
(1.00) 		0.308
(0.948) 		0.139
(0.799)
20p gain 101 (34%) 194 0.857
(1.00) 		0.108
(0.77) 		0.00452
(0.498) 		0.0846
(0.744) 		0.494
(1.00) 		0.163
(0.839) 		0.762
(1.00) 		0.42
(0.992) 		0.0134
(0.58) 		0.152
(0.827) 		0.245
(0.906) 		0.329
(0.964) 		0.669
(1.00) 		0.61
(1.00) 		0.737
(1.00) 		0.42
(0.992) 		0.813
(1.00) 		0.827
(1.00) 		0.53
(1.00) 		0.292
(0.933) 		0.359
(0.98) 		0.426
(0.993) 		0.363
(0.981) 		0.818
(1.00) 		0.588
(1.00) 		0.883
(1.00) 		0.863
(1.00) 		1
(1.00) 		0.0134
(0.58) 		0.984
(1.00) 		0.581
(1.00) 		0.34
(0.972) 		0.677
(1.00) 		0.258
(0.906) 		0.786
(1.00) 		0.266
(0.909) 		0.95
(1.00) 		0.105
(0.77) 		0.767
(1.00)
20q gain 114 (39%) 181 0.291
(0.933) 		0.0568
(0.678) 		0.079
(0.739) 		0.74
(1.00) 		0.738
(1.00) 		0.179
(0.853) 		0.606
(1.00) 		0.805
(1.00) 		0.236
(0.903) 		0.114
(0.774) 		0.358
(0.98) 		0.0859
(0.744) 		0.486
(1.00) 		0.592
(1.00) 		0.913
(1.00) 		0.805
(1.00) 		0.881
(1.00) 		0.533
(1.00) 		0.543
(1.00) 		0.668
(1.00) 		0.449
(1.00) 		0.313
(0.958) 		0.893
(1.00) 		0.527
(1.00) 		0.224
(0.897) 		0.752
(1.00) 		0.31
(0.954) 		0.611
(1.00) 		0.236
(0.903) 		0.95
(1.00) 		0.281
(0.924) 		0.492
(1.00) 		0.757
(1.00) 		0.651
(1.00) 		1
(1.00) 		0.238
(0.903) 		0.396
(0.981) 		0.041
(0.633) 		0.304
(0.941)
21q gain 37 (13%) 258 0.348
(0.978) 		0.0788
(0.739) 		0.317
(0.96) 		1
(1.00) 		0.614
(1.00) 		0.8
(1.00) 		0.728
(1.00) 		0.265
(0.909) 		0.825
(1.00) 		0.844
(1.00) 		0.729
(1.00) 		0.543
(1.00) 		0.0893
(0.744) 		0.475
(1.00) 		0.882
(1.00) 		0.265
(0.909) 		0.557
(1.00) 		0.421
(0.992) 		0.382
(0.981) 		0.646
(1.00) 		0.25
(0.906) 		0.952
(1.00) 		0.842
(1.00) 		0.534
(1.00) 		0.921
(1.00) 		0.182
(0.853) 		0.0637
(0.713) 		0.62
(1.00) 		0.825
(1.00) 		0.828
(1.00) 		0.0455
(0.649) 		0.454
(1.00) 		0.816
(1.00) 		0.639
(1.00) 		0.688
(1.00) 		0.574
(1.00) 		0.712
(1.00) 		0.0846
(0.744) 		0.369
(0.981)
22q gain 29 (10%) 266 0.25
(0.906) 		0.62
(1.00) 		0.71
(1.00) 		0.775
(1.00) 		1
(1.00) 		0.0319
(0.603) 		0.92
(1.00) 		0.778
(1.00) 		0.555
(1.00) 		0.199
(0.874) 		1
(1.00) 		0.389
(0.981) 		0.274
(0.922) 		0.626
(1.00) 		0.519
(1.00) 		0.778
(1.00) 		0.485
(1.00) 		0.348
(0.978) 		1
(1.00) 		0.544
(1.00) 		0.553
(1.00) 		0.391
(0.981) 		0.714
(1.00) 		0.765
(1.00) 		0.923
(1.00) 		0.806
(1.00) 		0.925
(1.00) 		1
(1.00) 		0.555
(1.00) 		0.725
(1.00) 		0.557
(1.00) 		0.834
(1.00) 		0.279
(0.923) 		1
(1.00) 		0.597
(1.00) 		1
(1.00) 		0.336
(0.97) 		0.589
(1.00) 		0.686
(1.00)
xq gain 43 (15%) 252 0.235
(0.903) 		0.958
(1.00) 		0.0518
(0.666) 		0.82
(1.00) 		0.358
(0.98) 		0.0702
(0.736) 		0.594
(1.00) 		0.392
(0.981) 		0.953
(1.00) 		0.14
(0.804) 		0.319
(0.96) 		0.618
(1.00) 		1
(1.00) 		0.674
(1.00) 		0.0579
(0.682) 		0.392
(0.981) 		0.597
(1.00) 		0.581
(1.00) 		0.298
(0.936) 		0.148
(0.827) 		0.816
(1.00) 		0.0982
(0.755) 		0.0101
(0.58) 		0.399
(0.983) 		0.573
(1.00) 		0.56
(1.00) 		0.628
(1.00) 		0.625
(1.00) 		0.953
(1.00) 		0.501
(1.00) 		0.624
(1.00) 		0.258
(0.906) 		0.0946
(0.747) 		0.474
(1.00) 		0.458
(1.00) 		1
(1.00) 		0.995
(1.00) 		0.771
(1.00)
1p loss 13 (4%) 282 0.446
(1.00) 		0.943
(1.00) 		0.114
(0.774) 		0.639
(1.00) 		0.081
(0.739) 		0.283
(0.927) 		0.915
(1.00) 		0.919
(1.00) 		0.865
(1.00) 		0.91
(1.00) 		0.258
(0.906) 		0.434
(1) 		0.302
(0.937) 		0.857
(1.00) 		0.919
(1.00) 		0.723
(1.00) 		0.744
(1.00) 		1
(1.00) 		0.0647
(0.718) 		0.589
(1.00) 		0.189
(0.857) 		0.166
(0.844) 		0.201
(0.874) 		0.524
(1.00) 		1
(1.00) 		0.36
(0.98) 		0.865
(1.00) 		0.794
(1.00) 		0.0776
(0.739) 		0.0727
(0.739) 		0.38
(0.981) 		0.894
(1.00) 		1
(1.00) 		0.158
(0.829) 		0.962
(1.00) 		0.402
(0.983)
1q loss 9 (3%) 286 0.511
(1.00) 		0.538
(1.00) 		0.385
(0.981) 		0.369
(0.981) 		0.302
(0.937) 		0.324
(0.961) 		0.705
(1.00) 		0.311
(0.955) 		0.257
(0.906) 		0.238
(0.903) 		1
(1.00) 		0.41
(0.987) 		0.715
(1.00) 		0.884
(1.00) 		0.311
(0.955) 		0.824
(1.00) 		0.664
(1.00) 		1
(1.00) 		0.0264
(0.58) 		0.55
(1.00) 		0.491
(1.00) 		0.235
(0.903) 		0.0511
(0.666) 		0.661
(1.00) 		1
(1.00) 		0.486
(1.00) 		0.677
(1.00) 		0.257
(0.906) 		0.12
(0.774) 		0.153
(0.827) 		0.0296
(0.599) 		0.216
(0.887) 		0.163
(0.839) 		1
(1.00) 		0.158
(0.829) 		0.523
(1.00) 		0.694
(1.00)
2p loss 18 (6%) 277 0.993
(1.00) 		0.759
(1.00) 		0.593
(1.00) 		0.516
(1.00) 		1
(1.00) 		1
(1.00) 		0.865
(1.00) 		0.977
(1.00) 		0.756
(1.00) 		0.88
(1.00) 		0.665
(1.00) 		0.237
(0.903) 		0.579
(1.00) 		0.771
(1.00) 		0.977
(1.00) 		0.988
(1.00) 		0.894
(1.00) 		1
(1.00) 		0.0307
(0.603) 		0.325
(0.961) 		0.115
(0.774) 		0.32
(0.96) 		0.0811
(0.739) 		0.197
(0.874) 		0.608
(1.00) 		0.895
(1.00) 		0.527
(1.00) 		0.756
(1.00) 		0.0176
(0.58) 		0.557
(1.00) 		0.743
(1.00) 		0.465
(1.00) 		0.806
(1.00) 		0.587
(1.00) 		1
(1.00) 		0.789
(1.00) 		0.539
(1.00)
2q loss 34 (12%) 261 0.411
(0.987) 		0.424
(0.993) 		0.367
(0.981) 		1
(1.00) 		0.358
(0.98) 		1
(1.00) 		0.883
(1.00) 		0.803
(1.00) 		0.835
(1.00) 		0.907
(1.00) 		0.744
(1.00) 		0.201
(0.874) 		1
(1.00) 		0.509
(1.00) 		0.981
(1.00) 		0.803
(1.00) 		0.167
(0.845) 		0.872
(1.00) 		1
(1.00) 		0.152
(0.827) 		0.69
(1.00) 		0.339
(0.972) 		0.312
(0.955) 		0.129
(0.784) 		0.601
(1.00) 		0.819
(1.00) 		0.639
(1.00) 		0.62
(1.00) 		0.835
(1.00) 		0.00658
(0.521) 		0.805
(1.00) 		0.706
(1.00) 		1
(1.00) 		0.334
(0.969) 		0.206
(0.877) 		0.637
(1.00) 		0.453
(1.00) 		0.295
(0.935)
3p loss 77 (26%) 218 0.861
(1.00) 		0.641
(1.00) 		0.321
(0.96) 		0.0246
(0.58) 		0.449
(1.00) 		0.568
(1.00) 		0.00679
(0.521) 		0.453
(1.00) 		0.00532
(0.509) 		0.632
(1.00) 		0.811
(1.00) 		0.966
(1.00) 		0.878
(1.00) 		0.737
(1.00) 		0.158
(0.829) 		0.453
(1.00) 		0.00648
(0.521) 		0.234
(0.903) 		1
(1.00) 		0.816
(1.00) 		0.583
(1.00) 		0.916
(1.00) 		0.564
(1.00) 		0.503
(1.00) 		0.101
(0.759) 		0.299
(0.936) 		0.698
(1.00) 		0.00778
(0.521) 		0.00532
(0.509) 		0.401
(0.983) 		0.717
(1.00) 		0.0939
(0.744) 		0.215
(0.887) 		0.111
(0.774) 		0.767
(1.00) 		0.798
(1.00) 		0.0149
(0.58) 		0.592
(1.00) 		0.471
(1.00)
3q loss 14 (5%) 281 0.619
(1.00) 		0.409
(0.987) 		0.584
(1.00) 		0.434
(1) 		1
(1.00) 		1
(1.00) 		0.458
(1.00) 		0.0132
(0.58) 		0.789
(1.00) 		0.784
(1.00) 		1
(1.00) 		0.252
(0.906) 		0.08
(0.739) 		0.616
(1.00) 		0.503
(1.00) 		0.0132
(0.58) 		0.607
(1.00) 		0.798
(1.00) 		0.719
(1.00) 		0.686
(1.00) 		0.814
(1.00) 		0.592
(1.00) 		0.285
(0.929) 		0.375
(0.981) 		0.568
(1.00) 		0.367
(0.981) 		0.789
(1.00) 		0.638
(1.00) 		1
(1.00) 		0.664
(1.00) 		0.673
(1.00) 		0.0918
(0.744) 		0.418
(0.992) 		0.0331
(0.603) 		0.421
(0.992) 		0.442
(1.00)
5p loss 17 (6%) 278 0.0284
(0.584) 		0.87
(1.00) 		0.236
(0.903) 		0.19
(0.857) 		0.563
(1.00) 		0.426
(0.993) 		0.444
(1.00) 		0.331
(0.966) 		0.0939
(0.744) 		1
(1.00) 		1
(1.00) 		0.9
(1.00) 		0.137
(0.799) 		0.329
(0.964) 		0.331
(0.966) 		0.265
(0.909) 		0.596
(1.00) 		0.382
(0.981) 		0.19
(0.857) 		0.515
(1.00) 		0.91
(1.00) 		0.952
(1.00) 		0.0219
(0.58) 		0.786
(1.00) 		0.421
(0.992) 		0.62
(1.00) 		0.276
(0.923) 		0.0939
(0.744) 		0.425
(0.993) 		0.162
(0.837) 		0.221
(0.894) 		0.681
(1.00) 		0.432
(0.999) 		0.587
(1.00) 		0.133
(0.795) 		0.846
(1.00) 		0.249
(0.906)
5q loss 49 (17%) 246 0.134
(0.796) 		0.0787
(0.739) 		0.159
(0.829) 		1
(1.00) 		1
(1.00) 		0.484
(1.00) 		0.583
(1.00) 		0.479
(1.00) 		0.172
(0.848) 		0.699
(1.00) 		1
(1.00) 		0.345
(0.977) 		0.276
(0.923) 		0.414
(0.988) 		0.0487
(0.657) 		0.479
(1.00) 		0.233
(0.903) 		0.652
(1.00) 		1
(1.00) 		0.966
(1.00) 		0.23
(0.903) 		0.209
(0.877) 		0.287
(0.932) 		0.0618
(0.706) 		0.668
(1.00) 		0.936
(1.00) 		0.668
(1.00) 		0.0889
(0.744) 		0.172
(0.848) 		0.99
(1.00) 		0.667
(1.00) 		0.326
(0.961) 		0.336
(0.97) 		0.214
(0.887) 		1
(1.00) 		0.421
(0.992) 		0.0617
(0.706) 		0.0965
(0.753) 		0.158
(0.829)
6p loss 46 (16%) 249 0.364
(0.981) 		0.54
(1.00) 		0.218
(0.887) 		0.492
(1.00) 		0.208
(0.877) 		1
(1.00) 		0.126
(0.78) 		0.809
(1.00) 		0.506
(1.00) 		0.415
(0.989) 		0.747
(1.00) 		0.513
(1.00) 		0.849
(1.00) 		0.748
(1.00) 		0.166
(0.844) 		0.809
(1.00) 		0.754
(1.00) 		0.898
(1.00) 		1
(1.00) 		0.109
(0.77) 		0.0259
(0.58) 		0.424
(0.992) 		0.255
(0.906) 		0.498
(1.00) 		0.994
(1.00) 		0.491
(1.00) 		0.592
(1.00) 		1
(1.00) 		0.506
(1.00) 		0.447
(1.00) 		0.345
(0.977) 		0.0723
(0.739) 		0.356
(0.98) 		0.465
(1.00) 		0.297
(0.936) 		1
(1.00) 		0.576
(1.00) 		0.989
(1.00)
6q loss 74 (25%) 221 0.0569
(0.678) 		0.983
(1.00) 		0.947
(1.00) 		0.56
(1.00) 		0.447
(1.00) 		0.428
(0.995) 		0.0859
(0.744) 		0.144
(0.816) 		0.585
(1.00) 		0.161
(0.832) 		0.603
(1.00) 		0.685
(1.00) 		0.633
(1.00) 		0.771
(1.00) 		0.0263
(0.58) 		0.144
(0.816) 		0.851
(1.00) 		0.323
(0.961) 		1
(1.00) 		0.274
(0.922) 		0.461
(1.00) 		0.702
(1.00) 		0.194
(0.868) 		0.803
(1.00) 		0.799
(1.00) 		0.894
(1.00) 		0.256
(0.906) 		1
(1.00) 		0.585
(1.00) 		0.794
(1.00) 		0.689
(1.00) 		0.0476
(0.652) 		0.922
(1.00) 		0.237
(0.903) 		1
(1.00) 		0.719
(1.00) 		0.961
(1.00) 		0.771
(1.00)
7p loss 26 (9%) 269 0.241
(0.903) 		0.0952
(0.748) 		0.36
(0.98) 		0.775
(1.00) 		0.599
(1.00) 		1
(1.00) 		0.736
(1.00) 		0.0795
(0.739) 		0.442
(1.00) 		0.16
(0.829) 		0.141
(0.806) 		0.0424
(0.634) 		0.154
(0.827) 		0.327
(0.961) 		0.633
(1.00) 		0.0795
(0.739) 		0.347
(0.978) 		0.862
(1.00) 		1
(1.00) 		0.335
(0.97) 		0.377
(0.981) 		0.361
(0.981) 		0.292
(0.933) 		0.24
(0.903) 		0.763
(1.00) 		0.294
(0.933) 		0.551
(1.00) 		0.78
(1.00) 		0.442
(1.00) 		0.451
(1.00) 		0.38
(0.981) 		0.674
(1.00) 		0.279
(0.923) 		0.769
(1.00) 		0.69
(1.00) 		0.509
(1.00) 		0.104
(0.77) 		0.505
(1.00)
7q loss 36 (12%) 259 0.0747
(0.739) 		0.0261
(0.58) 		0.789
(1.00) 		0.452
(1.00) 		1
(1.00) 		0.787
(1.00) 		0.529
(1.00) 		0.206
(0.877) 		0.138
(0.799) 		0.587
(1.00) 		0.209
(0.877) 		0.402
(0.983) 		0.229
(0.903) 		0.345
(0.977) 		0.132
(0.795) 		0.206
(0.877) 		0.308
(0.948) 		0.425
(0.993) 		0.543
(1.00) 		0.2
(0.874) 		0.314
(0.958) 		0.339
(0.972) 		0.0864
(0.744) 		0.208
(0.877) 		0.573
(1.00) 		0.294
(0.933) 		0.924
(1.00) 		0.348
(0.978) 		0.138
(0.799) 		0.902
(1.00) 		0.459
(1.00) 		0.638
(1.00) 		0.646
(1.00) 		0.382
(0.981) 		0.458
(1.00) 		0.449
(1.00) 		0.955
(1.00) 		0.0238
(0.58) 		0.91
(1.00)
8q loss 25 (8%) 270 0.92
(1.00) 		0.228
(0.903) 		0.674
(1.00) 		0.78
(1.00) 		0.605
(1.00) 		0.0192
(0.58) 		0.145
(0.819) 		0.862
(1.00) 		0.673
(1.00) 		0.738
(1.00) 		1
(1.00) 		0.948
(1.00) 		0.473
(1.00) 		0.456
(1.00) 		0.862
(1.00) 		0.43
(0.996) 		0.835
(1.00) 		1
(1.00) 		0.793
(1.00) 		0.453
(1.00) 		0.965
(1.00) 		0.988
(1.00) 		0.654
(1.00) 		0.28
(0.923) 		0.885
(1.00) 		0.718
(1.00) 		0.777
(1.00) 		0.673
(1.00) 		0.648
(1.00) 		0.0845
(0.744) 		0.253
(0.906) 		0.0755
(0.739) 		0.551
(1.00) 		1
(1.00) 		1
(1.00) 		0.214
(0.887) 		0.219
(0.888)
9p loss 53 (18%) 242 0.501
(1.00) 		0.0105
(0.58) 		0.234
(0.903) 		1
(1.00) 		0.393
(0.981) 		0.829
(1.00) 		0.916
(1.00) 		0.744
(1.00) 		0.682
(1.00) 		0.761
(1.00) 		0.378
(0.981) 		0.18
(0.853) 		0.229
(0.903) 		0.697
(1.00) 		0.281
(0.924) 		0.744
(1.00) 		0.434
(1) 		0.99
(1.00) 		1
(1.00) 		0.0483
(0.656) 		0.333
(0.969) 		0.679
(1.00) 		0.298
(0.936) 		0.0153
(0.58) 		0.239
(0.903) 		1
(1.00) 		0.271
(0.919) 		0.811
(1.00) 		0.682
(1.00) 		0.0623
(0.708) 		0.654
(1.00) 		0.938
(1.00) 		0.494
(1.00) 		0.664
(1.00) 		0.724
(1.00) 		1
(1.00) 		0.00784
(0.521) 		0.0868
(0.744)
10p loss 66 (22%) 229 0.297
(0.936) 		0.0791
(0.739) 		0.0904
(0.744) 		0.0462
(0.65) 		0.686
(1.00) 		0.545
(1.00) 		0.765
(1.00) 		0.944
(1.00) 		0.0183
(0.58) 		0.155
(0.827) 		0.789
(1.00) 		0.536
(1.00) 		0.246
(0.906) 		0.0182
(0.58) 		0.606
(1.00) 		0.944
(1.00) 		0.00357
(0.44) 		0.46
(1.00) 		1
(1.00) 		0.188
(0.857) 		0.54
(1.00) 		0.343
(0.977) 		0.0926
(0.744) 		0.368
(0.981) 		0.287
(0.932) 		0.033
(0.603) 		0.349
(0.978) 		0.0381
(0.626) 		0.0183
(0.58) 		0.317
(0.96) 		0.0681
(0.733) 		0.123
(0.774) 		0.874
(1.00) 		0.0989
(0.756) 		0.738
(1.00) 		0.246
(0.906) 		0.262
(0.908) 		0.0909
(0.744) 		0.0699
(0.736)
12p loss 40 (14%) 255 0.595
(1.00) 		0.9
(1.00) 		0.581
(1.00) 		1
(1.00) 		0.358
(0.98) 		0.619
(1.00) 		0.936
(1.00) 		0.263
(0.908) 		0.887
(1.00) 		0.643
(1.00) 		0.318
(0.96) 		0.484
(1.00) 		0.696
(1.00) 		0.11
(0.772) 		0.692
(1.00) 		0.263
(0.908) 		0.479
(1.00) 		0.394
(0.981) 		1
(1.00) 		0.122
(0.774) 		0.277
(0.923) 		0.539
(1.00) 		0.111
(0.774) 		0.971
(1.00) 		0.472
(1.00) 		0.586
(1.00) 		0.637
(1.00) 		1
(1.00) 		0.887
(1.00) 		0.29
(0.933) 		0.605
(1.00) 		0.379
(0.981) 		0.433
(1) 		0.0401
(0.633) 		0.125
(0.774) 		0.664
(1.00) 		0.863
(1.00) 		0.182
(0.854)
12q loss 15 (5%) 280 0.482
(1.00) 		0.0521
(0.667) 		0.0223
(0.58) 		0.369
(0.981) 		1
(1.00) 		0.105
(0.77) 		0.34
(0.972) 		0.138
(0.799) 		0.205
(0.877) 		0.504
(1.00) 		0.615
(1.00) 		0.147
(0.826) 		0.329
(0.964) 		0.506
(1.00) 		0.138
(0.799) 		0.838
(1.00) 		0.666
(1.00) 		1
(1.00) 		0.12
(0.774) 		0.55
(1.00) 		0.665
(1.00) 		0.181
(0.853) 		0.608
(1.00) 		0.387
(0.981) 		0.509
(1.00) 		0.109
(0.77) 		1
(1.00) 		0.205
(0.877) 		0.946
(1.00) 		0.362
(0.981) 		0.164
(0.839) 		0.783
(1.00) 		0.0756
(0.739) 		1
(1.00) 		0.386
(0.981) 		0.055
(0.676) 		0.0332
(0.603)
13q loss 80 (27%) 215 0.848
(1.00) 		0.19
(0.857) 		0.0802
(0.739) 		0.0246
(0.58) 		0.456
(1.00) 		0.202
(0.874) 		0.00545
(0.509) 		0.415
(0.989) 		0.00815
(0.521) 		0.742
(1.00) 		0.202
(0.874) 		0.777
(1.00) 		0.88
(1.00) 		0.116
(0.774) 		0.119
(0.774) 		0.415
(0.989) 		0.119
(0.774) 		0.0324
(0.603) 		0.53
(1.00) 		0.0793
(0.739) 		0.803
(1.00) 		0.991
(1.00) 		0.0252
(0.58) 		0.621
(1.00) 		0.373
(0.981) 		0.808
(1.00) 		0.804
(1.00) 		0.0229
(0.58) 		0.00815
(0.521) 		0.823
(1.00) 		0.847
(1.00) 		0.0258
(0.58) 		0.593
(1.00) 		0.65
(1.00) 		0.0484
(0.656) 		0.301
(0.937) 		0.136
(0.799) 		0.078
(0.739)
14q loss 35 (12%) 260 0.759
(1.00) 		0.0106
(0.58) 		0.571
(1.00) 		0.81
(1.00) 		0.354
(0.98) 		0.101
(0.759) 		0.387
(0.981) 		0.0359
(0.615) 		0.661
(1.00) 		0.507
(1.00) 		1
(1.00) 		0.423
(0.992) 		0.825
(1.00) 		0.0413
(0.633) 		0.95
(1.00) 		0.0359
(0.615) 		0.212
(0.883) 		0.89
(1.00) 		1
(1.00) 		0.404
(0.983) 		0.483
(1.00) 		0.627
(1.00) 		0.776
(1.00) 		0.0931
(0.744) 		0.898
(1.00) 		1
(1.00) 		0.0178
(0.58) 		1
(1.00) 		0.661
(1.00) 		0.628
(1.00) 		0.436
(1.00) 		0.903
(1.00) 		0.144
(0.816) 		0.116
(0.774) 		1
(1.00) 		0.237
(0.903) 		0.012
(0.58) 		0.879
(1.00)
15q loss 47 (16%) 248 0.449
(1.00) 		0.00483
(0.498) 		0.0665
(0.728) 		0.493
(1.00) 		0.115
(0.774) 		0.513
(1.00) 		0.186
(0.854) 		0.376
(0.981) 		0.801
(1.00) 		0.0217
(0.58) 		0.538
(1.00) 		0.821
(1.00) 		0.579
(1.00) 		0.00846
(0.521) 		0.0723
(0.739) 		0.376
(0.981) 		0.739
(1.00) 		0.402
(0.983) 		1
(1.00) 		0.907
(1.00) 		0.69
(1.00) 		0.0753
(0.739) 		0.58
(1.00) 		0.535
(1.00) 		0.517
(1.00) 		1
(1.00) 		0.0783
(0.739) 		0.789
(1.00) 		0.801
(1.00) 		0.989
(1.00) 		1
(1.00) 		0.725
(1.00) 		0.755
(1.00) 		0.898
(1.00) 		1
(1.00) 		0.23
(0.903) 		1
(1.00) 		0.00557
(0.509) 		0.0938
(0.744)
16p loss 32 (11%) 263 0.405
(0.983) 		0.0867
(0.744) 		0.0477
(0.652) 		0.0635
(0.712) 		0.179
(0.853) 		1
(1.00) 		0.237
(0.903) 		0.777
(1.00) 		0.396
(0.981) 		0.977
(1.00) 		0.476
(1.00) 		0.386
(0.981) 		0.509
(1.00) 		0.113
(0.774) 		0.707
(1.00) 		0.777
(1.00) 		0.198
(0.874) 		0.983
(1.00) 		1
(1.00) 		0.277
(0.923) 		0.479
(1.00) 		0.802
(1.00) 		0.719
(1.00) 		0.232
(0.903) 		0.28
(0.923) 		0.482
(1.00) 		0.648
(1.00) 		1
(1.00) 		0.396
(0.981) 		0.826
(1.00) 		0.0455
(0.649) 		0.153
(0.827) 		0.925
(1.00) 		0.885
(1.00) 		1
(1.00) 		0.508
(1.00) 		0.0446
(0.645) 		0.729
(1.00)
17p loss 94 (32%) 201 0.201
(0.874) 		0.0738
(0.739) 		0.92
(1.00) 		1
(1.00) 		0.724
(1.00) 		0.733
(1.00) 		0.344
(0.977) 		0.569
(1.00) 		0.507
(1.00) 		0.255
(0.906) 		0.242
(0.906) 		0.218
(0.887) 		0.0202
(0.58) 		0.035
(0.612) 		0.734
(1.00) 		0.569
(1.00) 		0.412
(0.988) 		0.327
(0.961) 		1
(1.00) 		0.6
(1.00) 		0.488
(1.00) 		0.383
(0.981) 		0.423
(0.992) 		0.184
(0.854) 		0.681
(1.00) 		0.667
(1.00) 		0.919
(1.00) 		1
(1.00) 		0.507
(1.00) 		0.511
(1.00) 		0.48
(1.00) 		0.2
(0.874) 		0.369
(0.981) 		0.578
(1.00) 		0.577
(1.00) 		0.837
(1.00) 		0.429
(0.996) 		0.0873
(0.744) 		0.729
(1.00)
17q loss 34 (12%) 261 0.552
(1.00) 		0.0131
(0.58) 		0.471
(1.00) 		0.79
(1.00) 		1
(1.00) 		1
(1.00) 		0.232
(0.903) 		0.841
(1.00) 		0.686
(1.00) 		0.263
(0.908) 		0.318
(0.96) 		0.94
(1.00) 		0.137
(0.799) 		0.706
(1.00) 		0.0211
(0.58) 		0.841
(1.00) 		0.34
(0.972) 		0.632
(1.00) 		1
(1.00) 		0.915
(1.00) 		0.354
(0.98) 		0.408
(0.987) 		0.845
(1.00) 		0.296
(0.936) 		0.184
(0.854) 		0.491
(1.00) 		0.496
(1.00) 		0.422
(0.992) 		0.686
(1.00) 		0.97
(1.00) 		0.798
(1.00) 		0.0159
(0.58) 		1
(1.00) 		0.0997
(0.759) 		0.351
(0.98) 		0.422
(0.992) 		1
(1.00) 		0.0147
(0.58) 		0.373
(0.981)
18p loss 54 (18%) 241 0.64
(1.00) 		0.374
(0.981) 		0.924
(1.00) 		1
(1.00) 		1
(1.00) 		0.823
(1.00) 		0.0163
(0.58) 		0.192
(0.862) 		0.445
(1.00) 		0.934
(1.00) 		1
(1.00) 		0.621
(1.00) 		0.861
(1.00) 		0.455
(1.00) 		0.43
(0.997) 		0.192
(0.862) 		0.0331
(0.603) 		0.758
(1.00) 		0.536
(1.00) 		0.876
(1.00) 		0.23
(0.903) 		0.432
(0.999) 		0.71
(1.00) 		0.201
(0.874) 		0.88
(1.00) 		0.788
(1.00) 		0.669
(1.00) 		0.0741
(0.739) 		0.445
(1.00) 		0.537
(1.00) 		0.809
(1.00) 		0.155
(0.827) 		0.0683
(0.733) 		0.0607
(0.706) 		0.0694
(0.736) 		0.0261
(0.58) 		0.349
(0.978) 		0.368
(0.981)
19q loss 30 (10%) 265 0.138
(0.799) 		0.209
(0.877) 		0.235
(0.903) 		0.558
(1.00) 		0.563
(1.00) 		1
(1.00) 		0.0859
(0.744) 		0.25
(0.906) 		0.952
(1.00) 		0.448
(1.00) 		1
(1.00) 		0.708
(1.00) 		0.174
(0.851) 		0.255
(0.906) 		0.503
(1.00) 		0.25
(0.906) 		0.4
(0.983) 		0.184
(0.854) 		1
(1.00) 		0.499
(1.00) 		0.377
(0.981) 		0.962
(1.00) 		0.782
(1.00) 		0.415
(0.989) 		0.763
(1.00) 		0.887
(1.00) 		0.0653
(0.72) 		0.179
(0.853) 		0.952
(1.00) 		0.729
(1.00) 		0.724
(1.00) 		0.255
(0.906) 		0.78
(1.00) 		0.457
(1.00) 		0.21
(0.877) 		0.263
(0.908) 		0.659
(1.00) 		0.223
(0.897) 		0.632
(1.00)
20p loss 22 (7%) 273 0.535
(1.00) 		0.0409
(0.633) 		1
(1.00) 		1
(1.00) 		0.563
(1.00) 		0.418
(0.992) 		0.765
(1.00) 		0.0465
(0.65) 		0.972
(1.00) 		0.373
(0.981) 		0.646
(1.00) 		0.054
(0.67) 		0.617
(1.00) 		0.959
(1.00) 		0.414
(0.988) 		0.0465
(0.65) 		0.0437
(0.641) 		0.656
(1.00) 		0.107
(0.77) 		0.481
(1.00) 		0.28
(0.923) 		0.0362
(0.615) 		0.713
(1.00) 		0.627
(1.00) 		0.786
(1.00) 		1
(1.00) 		0.95
(1.00) 		1
(1.00) 		0.972
(1.00) 		0.983
(1.00) 		0.733
(1.00) 		0.911
(1.00) 		0.151
(0.827) 		0.611
(1.00) 		1
(1.00) 		1
(1.00) 		0.0759
(0.739) 		0.945
(1.00)
20q loss 12 (4%) 283 0.00244
(0.354) 		0.0146
(0.58) 		0.63
(1.00) 		0.677
(1.00) 		0.302
(0.937) 		1
(1.00) 		0.739
(1.00) 		0.03
(0.6) 		0.391
(0.981) 		0.319
(0.96) 		1
(1.00) 		0.0664
(0.728) 		0.104
(0.77) 		0.562
(1.00) 		0.03
(0.6) 		0.456
(1.00) 		0.858
(1.00) 		0.586
(1.00) 		0.686
(1.00) 		0.0273
(0.584) 		0.367
(0.981) 		0.724
(1.00) 		0.552
(1.00) 		0.0528
(0.667) 		1
(1.00) 		0.391
(0.981) 		0.706
(1.00) 		0.153
(0.827) 		0.405
(0.983) 		0.414
(0.988) 		0.656
(1.00) 		0.516
(1.00) 		1
(1.00) 		0.0137
(0.58) 		0.983
(1.00)
21q loss 49 (17%) 246 0.074
(0.739) 		0.482
(1.00) 		0.108
(0.77) 		1
(1.00) 		1
(1.00) 		0.493
(1.00) 		0.689
(1.00) 		0.537
(1.00) 		0.576
(1.00) 		0.119
(0.774) 		0.133
(0.795) 		0.0642
(0.716) 		0.717
(1.00) 		0.011
(0.58) 		0.537
(1.00) 		0.07
(0.736) 		0.00784
(0.521) 		0.382
(0.981) 		0.0184
(0.58) 		0.377
(0.981) 		0.717
(1.00) 		0.0348
(0.612) 		0.0332
(0.603) 		0.517
(1.00) 		0.459
(1.00) 		0.682
(1.00) 		0.822
(1.00) 		0.576
(1.00) 		0.193
(0.865) 		0.818
(1.00) 		0.201
(0.874) 		0.103
(0.77) 		0.303
(0.939) 		0.51
(1.00) 		0.711
(1.00) 		0.518
(1.00) 		0.217
(0.887)
22q loss 71 (24%) 224 0.224
(0.897) 		0.447
(1.00) 		0.436
(1.00) 		0.854
(1.00) 		0.721
(1.00) 		0.0868
(0.744) 		0.978
(1.00) 		0.78
(1.00) 		0.554
(1.00) 		0.763
(1.00) 		0.792
(1.00) 		0.614
(1.00) 		0.873
(1.00) 		0.798
(1.00) 		0.00433
(0.495) 		0.78
(1.00) 		0.249
(0.906) 		0.358
(0.98) 		0.53
(1.00) 		0.139
(0.801) 		0.19
(0.857) 		0.177
(0.853) 		0.399
(0.983) 		0.239
(0.903) 		0.864
(1.00) 		0.924
(1.00) 		0.0399
(0.633) 		0.459
(1.00) 		0.554
(1.00) 		0.336
(0.97) 		0.322
(0.961) 		0.111
(0.774) 		0.628
(1.00) 		0.245
(0.906) 		0.391
(0.981) 		0.246
(0.906) 		0.659
(1.00) 		0.49
(1.00) 		0.349
(0.978)
xp loss 65 (22%) 230 0.579
(1.00) 		0.165
(0.841) 		0.527
(1.00) 		0.703
(1.00) 		1
(1.00) 		0.683
(1.00) 		0.0807
(0.739) 		0.409
(0.987) 		0.828
(1.00) 		0.0836
(0.744) 		0.172
(0.848) 		0.715
(1.00) 		0.326
(0.961) 		0.651
(1.00) 		0.966
(1.00) 		0.409
(0.987) 		0.414
(0.988) 		0.728
(1.00) 		0.188
(0.857) 		0.0562
(0.678) 		0.216
(0.887) 		0.129
(0.784) 		0.019
(0.58) 		0.513
(1.00) 		0.756
(1.00) 		0.184
(0.854) 		0.337
(0.97) 		1
(1.00) 		0.828
(1.00) 		0.5
(1.00) 		0.0157
(0.58) 		0.0336
(0.607) 		0.183
(0.854) 		0.175
(0.853) 		0.519
(1.00) 		1
(1.00) 		0.95
(1.00) 		0.147
(0.826) 		0.657
(1.00)
xq loss 58 (20%) 237 0.16
(0.829) 		0.334
(0.969) 		0.698
(1.00) 		0.842
(1.00) 		0.179
(0.853) 		0.401
(0.983) 		0.178
(0.853) 		0.996
(1.00) 		0.628
(1.00) 		0.147
(0.826) 		0.789
(1.00) 		0.459
(1.00) 		0.128
(0.781) 		0.615
(1.00) 		0.377
(0.981) 		0.996
(1.00) 		0.772
(1.00) 		0.969
(1.00) 		0.188
(0.857) 		0.191
(0.862) 		0.54
(1.00) 		0.201
(0.874) 		0.0211
(0.58) 		0.497
(1.00) 		0.545
(1.00) 		0.0424
(0.634) 		0.464
(1.00) 		0.832
(1.00) 		0.628
(1.00) 		0.947
(1.00) 		0.00481
(0.498) 		0.289
(0.933) 		0.751
(1.00) 		0.573
(1.00) 		0.516
(1.00) 		0.0975
(0.754) 		0.95
(1.00) 		0.307
(0.947) 		0.533
(1.00)
'9q gain' versus 'PREGNANCIES_COUNT_LIVE_BIRTH'

P value = 0.000817 (Wilcoxon-test), Q value = 0.25

Table S1.  Gene #18: '9q gain' versus Clinical Feature #23: 'PREGNANCIES_COUNT_LIVE_BIRTH'

nPatients Mean (Std.Dev)
ALL 251 2.8 (2.0)
9Q GAIN MUTATED 41 3.6 (2.0)
9Q GAIN WILD-TYPE 210 2.7 (2.0)

Figure S1.  Get High-res Image Gene #18: '9q gain' versus Clinical Feature #23: 'PREGNANCIES_COUNT_LIVE_BIRTH'

'xp gain' versus 'PREGNANCIES_COUNT_LIVE_BIRTH'

P value = 0.00113 (Wilcoxon-test), Q value = 0.25

Table S2.  Gene #40: 'xp gain' versus Clinical Feature #23: 'PREGNANCIES_COUNT_LIVE_BIRTH'

nPatients Mean (Std.Dev)
ALL 251 2.8 (2.0)
XP GAIN MUTATED 37 3.9 (2.6)
XP GAIN WILD-TYPE 214 2.6 (1.9)

Figure S2.  Get High-res Image Gene #40: 'xp gain' versus Clinical Feature #23: 'PREGNANCIES_COUNT_LIVE_BIRTH'

'4p loss' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0011 (Wilcoxon-test), Q value = 0.25

Table S3.  Gene #48: '4p loss' versus Clinical Feature #9: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 150 0.9 (2.1)
4P LOSS MUTATED 59 1.4 (2.4)
4P LOSS WILD-TYPE 91 0.6 (1.7)

Figure S3.  Get High-res Image Gene #48: '4p loss' versus Clinical Feature #9: 'NUMBER_OF_LYMPH_NODES'

'4p loss' versus 'LYMPH_NODES_EXAMINED_HE_COUNT'

P value = 0.0011 (Wilcoxon-test), Q value = 0.25

Table S4.  Gene #48: '4p loss' versus Clinical Feature #29: 'LYMPH_NODES_EXAMINED_HE_COUNT'

nPatients Mean (Std.Dev)
ALL 150 0.9 (2.1)
4P LOSS MUTATED 59 1.4 (2.4)
4P LOSS WILD-TYPE 91 0.6 (1.7)

Figure S4.  Get High-res Image Gene #48: '4p loss' versus Clinical Feature #29: 'LYMPH_NODES_EXAMINED_HE_COUNT'

'4q loss' versus 'RADIATION_THERAPY'

P value = 0.000851 (Fisher's exact test), Q value = 0.25

Table S5.  Gene #49: '4q loss' versus Clinical Feature #6: 'RADIATION_THERAPY'

nPatients NO YES
ALL 53 125
4Q LOSS MUTATED 8 51
4Q LOSS WILD-TYPE 45 74

Figure S5.  Get High-res Image Gene #49: '4q loss' versus Clinical Feature #6: 'RADIATION_THERAPY'

'8p loss' versus 'TOBACCO_SMOKING_YEAR_STOPPED'

P value = 0.000626 (Wilcoxon-test), Q value = 0.23

Table S6.  Gene #56: '8p loss' versus Clinical Feature #15: 'TOBACCO_SMOKING_YEAR_STOPPED'

nPatients Mean (Std.Dev)
ALL 43 1999.7 (13.6)
8P LOSS MUTATED 12 2009.2 (4.3)
8P LOSS WILD-TYPE 31 1996.0 (14.3)

Figure S6.  Get High-res Image Gene #56: '8p loss' versus Clinical Feature #15: 'TOBACCO_SMOKING_YEAR_STOPPED'

'9q loss' versus 'YEARS_TO_BIRTH'

P value = 0.00115 (Wilcoxon-test), Q value = 0.25

Table S7.  Gene #59: '9q loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 293 48.1 (13.8)
9Q LOSS MUTATED 48 54.6 (15.1)
9Q LOSS WILD-TYPE 245 46.8 (13.2)

Figure S7.  Get High-res Image Gene #59: '9q loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'10q loss' versus 'NEOPLASM_HISTOLOGIC_GRADE'

P value = 0.00056 (Fisher's exact test), Q value = 0.23

Table S8.  Gene #61: '10q loss' versus Clinical Feature #14: 'NEOPLASM_HISTOLOGIC_GRADE'

nPatients G1 G2 G3 G4 GX
ALL 18 129 115 1 24
10Q LOSS MUTATED 3 20 43 1 6
10Q LOSS WILD-TYPE 15 109 72 0 18

Figure S8.  Get High-res Image Gene #61: '10q loss' versus Clinical Feature #14: 'NEOPLASM_HISTOLOGIC_GRADE'

'11p loss' versus 'YEARS_TO_BIRTH'

P value = 0.000512 (Wilcoxon-test), Q value = 0.23

Table S9.  Gene #62: '11p loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 293 48.1 (13.8)
11P LOSS MUTATED 99 52.3 (14.0)
11P LOSS WILD-TYPE 194 46.0 (13.2)

Figure S9.  Get High-res Image Gene #62: '11p loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'11p loss' versus 'AGE_AT_DIAGNOSIS'

P value = 0.000436 (Wilcoxon-test), Q value = 0.23

Table S10.  Gene #62: '11p loss' versus Clinical Feature #38: 'AGE_AT_DIAGNOSIS'

nPatients Mean (Std.Dev)
ALL 295 48.2 (13.8)
11P LOSS MUTATED 100 52.4 (14.0)
11P LOSS WILD-TYPE 195 46.1 (13.2)

Figure S10.  Get High-res Image Gene #62: '11p loss' versus Clinical Feature #38: 'AGE_AT_DIAGNOSIS'

'11q loss' versus 'YEARS_TO_BIRTH'

P value = 8.58e-05 (Wilcoxon-test), Q value = 0.22

Table S11.  Gene #63: '11q loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 293 48.1 (13.8)
11Q LOSS MUTATED 115 52.2 (13.8)
11Q LOSS WILD-TYPE 178 45.5 (13.1)

Figure S11.  Get High-res Image Gene #63: '11q loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'11q loss' versus 'AGE_AT_DIAGNOSIS'

P value = 0.000136 (Wilcoxon-test), Q value = 0.22

Table S12.  Gene #63: '11q loss' versus Clinical Feature #38: 'AGE_AT_DIAGNOSIS'

nPatients Mean (Std.Dev)
ALL 295 48.2 (13.8)
11Q LOSS MUTATED 115 52.2 (13.8)
11Q LOSS WILD-TYPE 180 45.6 (13.2)

Figure S12.  Get High-res Image Gene #63: '11q loss' versus Clinical Feature #38: 'AGE_AT_DIAGNOSIS'

'16q loss' versus 'HISTOLOGICAL_TYPE'

P value = 0.00026 (Fisher's exact test), Q value = 0.23

Table S13.  Gene #70: '16q loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

nPatients ADENOSQUAMOUS CERVICAL SQUAMOUS CELL CARCINOMA ENDOCERVICAL ADENOCARCINOMA OF THE USUAL TYPE ENDOCERVICAL TYPE OF ADENOCARCINOMA ENDOMETRIOID ADENOCARCINOMA OF ENDOCERVIX MUCINOUS ADENOCARCINOMA OF ENDOCERVICAL TYPE
ALL 6 242 6 21 3 17
16Q LOSS MUTATED 0 26 4 7 1 5
16Q LOSS WILD-TYPE 6 216 2 14 2 12

Figure S13.  Get High-res Image Gene #70: '16q loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

'18q loss' versus 'HISTOLOGICAL_TYPE'

P value = 0.00034 (Fisher's exact test), Q value = 0.23

Table S14.  Gene #74: '18q loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

nPatients ADENOSQUAMOUS CERVICAL SQUAMOUS CELL CARCINOMA ENDOCERVICAL ADENOCARCINOMA OF THE USUAL TYPE ENDOCERVICAL TYPE OF ADENOCARCINOMA ENDOMETRIOID ADENOCARCINOMA OF ENDOCERVIX MUCINOUS ADENOCARCINOMA OF ENDOCERVICAL TYPE
ALL 6 242 6 21 3 17
18Q LOSS MUTATED 0 50 1 12 2 8
18Q LOSS WILD-TYPE 6 192 5 9 1 9

Figure S14.  Get High-res Image Gene #74: '18q loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

'19p loss' versus 'Time to Death'

P value = 0.000634 (logrank test), Q value = 0.23

Table S15.  Gene #75: '19p loss' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 282 68 0.1 - 210.7 (22.6)
19P LOSS MUTATED 57 22 0.1 - 147.3 (20.9)
19P LOSS WILD-TYPE 225 46 0.1 - 210.7 (24.0)

Figure S15.  Get High-res Image Gene #75: '19p loss' versus Clinical Feature #1: 'Time to Death'

Methods & Data
Input

  • Copy number data file = broad_values_by_arm.txt from GISTIC pipeline

  • Processed Copy number data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/CESC-TP/22507939/transformed.cor.cli.txt

  • Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/CESC-TP/22489370/CESC-TP.merged_data.txt

  • Number of patients = 295

  • Number of significantly arm-level cnvs = 82

  • Number of selected clinical features = 39

  • Exclude regions that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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