Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.043 0.121 -9999.0 0.0 -0.413 9.0 9.0 IHH -0.122 0.198 -9999.0 0.0 -0.415 94.0 94.0 SHH Np/Cholesterol/GAS1 -0.096 0.104 -9999.0 0.0 -0.207 139.0 139.0 LRPAP1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.096 0.103 0.206 139.0 -9999.0 0.0 139.0 SMO/beta Arrestin2 -0.08 0.167 -9999.0 0.0 -0.306 94.0 94.0 SMO -0.088 0.175 -9999.0 0.0 -0.325 94.0 94.0 AKT1 -0.032 0.087 -9999.0 0.0 -0.254 9.0 9.0 ARRB2 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.085 0.171 -9999.0 0.0 -0.4 69.0 69.0 ADRBK1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.086 0.173 -9999.0 0.0 -0.321 94.0 94.0 STIL -0.038 0.095 -9999.0 0.0 -0.256 12.0 12.0 DHH N/PTCH2 -0.02 0.071 -9999.0 0.0 -0.275 22.0 22.0 DHH N/PTCH1 -0.045 0.109 -9999.0 0.0 -0.203 96.0 96.0 PIK3CA 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.007 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.071 0.167 -9999.0 0.0 -0.544 9.0 9.0 determination of left/right symmetry -0.086 0.173 -9999.0 0.0 -0.321 94.0 94.0 PIK3R1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.071 0.166 -9999.0 0.0 -0.54 9.0 9.0 IHH N/Hhip -0.069 0.128 -9999.0 0.0 -0.253 94.0 94.0 DHH N/Hhip -0.008 0.045 -9999.0 0.0 -0.262 9.0 9.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.086 0.173 -9999.0 0.0 -0.321 94.0 94.0 pancreas development -0.006 0.066 -9999.0 0.0 -0.382 9.0 9.0 HHAT 0.006 0.023 -9999.0 0.0 -0.4 1.0 1.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.178 0.203 -9999.0 0.0 -0.4 138.0 138.0 somite specification -0.086 0.173 -9999.0 0.0 -0.321 94.0 94.0 SHH Np/Cholesterol/PTCH1 -0.039 0.099 -9999.0 0.0 -0.268 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.019 0.056 -9999.0 0.0 -0.204 23.0 23.0 SHH Np/Cholesterol/Megalin -0.006 0.028 -9999.0 0.0 -0.218 2.0 2.0 SHH 0.004 0.033 -9999.0 0.0 -0.171 10.0 10.0 catabolic process -0.056 0.125 -9999.0 0.0 -0.237 96.0 96.0 SMO/Vitamin D3 -0.059 0.132 -9999.0 0.0 -0.243 95.0 95.0 SHH Np/Cholesterol/Hhip -0.01 0.039 -9999.0 0.0 -0.204 9.0 9.0 LRP2 0.001 0.035 -9999.0 0.0 -0.248 6.0 6.0 receptor-mediated endocytosis -0.074 0.107 -9999.0 0.0 -0.327 17.0 17.0 SHH Np/Cholesterol/BOC -0.05 0.089 -9999.0 0.0 -0.209 69.0 69.0 SHH Np/Cholesterol/CDO -0.022 0.061 -9999.0 0.0 -0.203 28.0 28.0 mesenchymal cell differentiation 0.01 0.039 0.203 9.0 -9999.0 0.0 9.0 mol:Vitamin D3 -0.038 0.1 -9999.0 0.0 -0.27 10.0 10.0 IHH N/PTCH2 -0.081 0.139 -9999.0 0.0 -0.263 105.0 105.0 CDON -0.029 0.116 -9999.0 0.0 -0.4 27.0 27.0 IHH N/PTCH1 -0.055 0.128 -9999.0 0.0 -0.239 96.0 96.0 Megalin/LRPAP1 -0.003 0.022 -9999.0 0.0 -0.158 6.0 6.0 PTCH2 -0.022 0.105 -9999.0 0.0 -0.4 22.0 22.0 SHH Np/Cholesterol -0.004 0.023 -9999.0 0.0 -0.21 1.0 1.0 PTCH1 -0.056 0.125 -9999.0 0.0 -0.238 96.0 96.0 HHIP -0.006 0.066 -9999.0 0.0 -0.383 9.0 9.0