Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.022 0.016 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.084 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.033 0.028 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.002 0.041 -9999.0 0.0 -0.309 5.0 5.0 EPHA2 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.074 0.037 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.102 0.131 -9999.0 0.0 -0.457 35.0 35.0 CTNND1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.073 0.037 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.079 0.048 -9999.0 0.0 -0.243 10.0 10.0 EGF -0.013 0.088 -9999.0 0.0 -0.4 15.0 15.0 NCKAP1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.058 0.029 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization -0.084 0.033 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.069 0.035 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.085 0.033 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.054 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.059 0.034 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.074 0.037 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.215 0.086 -9999.0 0.0 -0.248 264.0 264.0 EGFR/EGFR/EGF/EGF -0.081 0.049 -9999.0 0.0 -0.255 15.0 15.0 RhoA/GDP -0.076 0.03 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.062 0.034 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.005 0.033 -9999.0 0.0 -0.399 2.0 2.0 GIT1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.005 0.033 -9999.0 0.0 -0.4 2.0 2.0 IGF1 -0.12 0.189 -9999.0 0.0 -0.4 95.0 95.0 DIAPH1 0.01 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.084 0.033 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.054 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.063 0.034 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.066 0.036 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.07 0.027 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.059 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.08 0.048 -9999.0 0.0 -0.246 10.0 10.0 HGF/MET -0.095 0.07 -9999.0 0.0 -0.263 38.0 38.0 HGF -0.049 0.139 -9999.0 0.0 -0.396 42.0 42.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.022 0.016 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation -0.022 0.027 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.162 0.05 -9999.0 0.0 -0.186 241.0 241.0 KIFC3 -0.074 0.037 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.074 0.037 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.084 0.033 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.074 0.037 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.074 0.037 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.046 0.018 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.102 0.038 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.128 0.092 -9999.0 0.0 -0.267 85.0 85.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.074 0.037 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.05 0.034 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.022 0.016 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.062 0.034 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.022 0.016 -9999.0 0.0 -9999.0 0.0 0.0