Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.123 0.257 -9999.0 0.0 -0.916 3.0 3.0 IHH -0.117 0.373 -9999.0 0.0 -1.35 3.0 3.0 SHH Np/Cholesterol/GAS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 -0.093 0.241 -9999.0 0.0 -0.843 3.0 3.0 SMO -0.1 0.257 -9999.0 0.0 -0.9 3.0 3.0 AKT1 -0.032 0.09 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.085 0.257 -9999.0 0.0 -0.877 3.0 3.0 STIL -0.064 0.211 -9999.0 0.0 -0.779 2.0 2.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.093 0.239 -9999.0 0.0 -0.875 3.0 3.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.136 0.272 -9999.0 0.0 -1.058 2.0 2.0 determination of left/right symmetry -0.085 0.257 -9999.0 0.0 -0.877 3.0 3.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.135 0.268 -9999.0 0.0 -0.969 3.0 3.0 IHH N/Hhip -0.459 0.594 -9999.0 0.0 -1.187 14.0 14.0 DHH N/Hhip -0.362 0.512 -9999.0 0.0 -1.087 12.0 12.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.085 0.257 -9999.0 0.0 -0.877 3.0 3.0 pancreas development -0.434 0.614 -9999.0 0.0 -1.302 12.0 12.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 somite specification -0.085 0.257 -9999.0 0.0 -0.877 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.08 0.218 -9999.0 0.0 -0.794 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.182 0.365 -9999.0 0.0 -0.925 7.0 7.0 SHH 0.022 0.002 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.099 0.262 -9999.0 0.0 -0.948 3.0 3.0 SMO/Vitamin D3 -0.085 0.228 -9999.0 0.0 -0.821 3.0 3.0 SHH Np/Cholesterol/Hhip -0.308 0.436 -9999.0 0.0 -0.925 12.0 12.0 LRP2 -0.259 0.515 -9999.0 0.0 -1.306 7.0 7.0 receptor-mediated endocytosis -0.164 0.314 -9999.0 0.0 -1.188 2.0 2.0 SHH Np/Cholesterol/BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.304 0.43 0.912 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 -0.068 0.229 -9999.0 0.0 -0.813 3.0 3.0 IHH N/PTCH2 -0.082 0.282 -9999.0 0.0 -1.015 3.0 3.0 CDON 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.099 0.27 -9999.0 0.0 -0.973 3.0 3.0 Megalin/LRPAP1 -0.214 0.428 -9999.0 0.0 -1.084 7.0 7.0 PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.1 0.264 -9999.0 0.0 -0.954 3.0 3.0 HHIP -0.435 0.616 -9999.0 0.0 -1.306 12.0 12.0