Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.019 0.139 -9999.0 0.0 -0.602 19.0 19.0 IHH 0.004 0.088 -9999.0 0.0 -0.489 13.0 13.0 SHH Np/Cholesterol/GAS1 -0.098 0.202 -9999.0 0.0 -0.479 88.0 88.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.098 0.201 0.475 88.0 -9999.0 0.0 88.0 SMO/beta Arrestin2 0.014 0.096 -9999.0 0.0 -0.539 5.0 5.0 SMO 0.009 0.101 -9999.0 0.0 -0.542 6.0 6.0 AKT1 0.024 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.003 0.062 -9999.0 0.0 -0.436 9.0 9.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.009 0.1 -9999.0 0.0 -0.533 6.0 6.0 STIL -0.042 0.168 -9999.0 0.0 -0.471 11.0 11.0 DHH N/PTCH2 0.003 0.069 -9999.0 0.0 -0.313 20.0 20.0 DHH N/PTCH1 0.014 0.099 -9999.0 0.0 -0.52 6.0 6.0 PIK3CA 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.007 0.089 -9999.0 0.0 -0.436 19.0 19.0 PTHLH 0.016 0.16 -9999.0 0.0 -0.843 10.0 10.0 determination of left/right symmetry 0.009 0.1 -9999.0 0.0 -0.533 6.0 6.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.017 0.158 -9999.0 0.0 -0.831 10.0 10.0 IHH N/Hhip -0.062 0.157 -9999.0 0.0 -0.349 100.0 100.0 DHH N/Hhip -0.063 0.151 -9999.0 0.0 -0.329 106.0 106.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.009 0.1 -9999.0 0.0 -0.533 6.0 6.0 pancreas development -0.084 0.184 -9999.0 0.0 -0.435 98.0 98.0 HHAT 0.008 0.042 -9999.0 0.0 -0.436 4.0 4.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.055 0.167 -9999.0 0.0 -0.459 65.0 65.0 somite specification 0.009 0.1 -9999.0 0.0 -0.533 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.049 0.176 -9999.0 0.0 -0.393 87.0 87.0 SHH Np/Cholesterol/PTCH2 -0.064 0.176 -9999.0 0.0 -0.435 83.0 83.0 SHH Np/Cholesterol/Megalin -0.105 0.217 -9999.0 0.0 -0.469 113.0 113.0 SHH -0.086 0.22 -9999.0 0.0 -0.541 86.0 86.0 catabolic process 0.021 0.092 -9999.0 0.0 -0.547 5.0 5.0 SMO/Vitamin D3 -0.039 0.17 -9999.0 0.0 -0.512 10.0 10.0 SHH Np/Cholesterol/Hhip -0.114 0.19 -9999.0 0.0 -0.455 85.0 85.0 LRP2 -0.058 0.208 -9999.0 0.0 -0.731 40.0 40.0 receptor-mediated endocytosis -0.053 0.178 -9999.0 0.0 -0.544 19.0 19.0 SHH Np/Cholesterol/BOC -0.067 0.179 -9999.0 0.0 -0.44 82.0 82.0 SHH Np/Cholesterol/CDO -0.062 0.175 -9999.0 0.0 -0.435 82.0 82.0 mesenchymal cell differentiation 0.113 0.188 0.452 85.0 -9999.0 0.0 85.0 mol:Vitamin D3 -0.047 0.177 -9999.0 0.0 -0.391 87.0 87.0 IHH N/PTCH2 0.013 0.06 -9999.0 0.0 -0.394 5.0 5.0 CDON 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.022 0.093 -9999.0 0.0 -0.552 5.0 5.0 Megalin/LRPAP1 -0.036 0.16 -9999.0 0.0 -0.551 40.0 40.0 PTCH2 0.011 0.035 -9999.0 0.0 -0.731 1.0 1.0 SHH Np/Cholesterol -0.07 0.175 -9999.0 0.0 -0.431 86.0 86.0 PTCH1 0.021 0.093 -9999.0 0.0 -0.549 5.0 5.0 HHIP -0.084 0.184 -9999.0 0.0 -0.436 98.0 98.0