Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.028 0.061 0.301 14.0 -0.237 1.0 15.0 KIRREL 0.022 0.047 -9999.0 0.0 -0.407 5.0 5.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.028 0.061 0.238 1.0 -0.301 14.0 15.0 PLCG1 0.016 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.044 0.075 -9999.0 0.0 -0.242 18.0 18.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.032 -9999.0 0.0 -0.21 3.0 3.0 FYN 0.012 0.061 0.272 11.0 -0.242 4.0 15.0 mol:Ca2+ 0.028 0.056 -9999.0 0.0 -0.232 12.0 12.0 mol:DAG 0.029 0.056 -9999.0 0.0 -0.232 12.0 12.0 NPHS2 0.014 0.045 -9999.0 0.0 -0.423 4.0 4.0 mol:IP3 0.029 0.056 -9999.0 0.0 -0.232 12.0 12.0 regulation of endocytosis 0.036 0.05 0.211 1.0 -0.334 1.0 2.0 Nephrin/NEPH1/podocin/Cholesterol 0.036 0.054 0.212 1.0 -0.227 16.0 17.0 establishment of cell polarity 0.028 0.061 0.237 1.0 -0.301 14.0 15.0 Nephrin/NEPH1/podocin/NCK1-2 0.065 0.058 -9999.0 0.0 -0.381 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 0.038 0.051 0.219 1.0 -0.338 1.0 2.0 NPHS1 0.015 0.068 0.329 1.0 -0.429 9.0 10.0 Nephrin/NEPH1/podocin 0.038 0.049 0.215 1.0 -0.235 5.0 6.0 TJP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.03 0.057 -9999.0 0.0 -0.233 12.0 12.0 CD2AP 0.016 0.068 -9999.0 0.0 -0.395 12.0 12.0 Nephrin/NEPH1/podocin/GRB2 0.051 0.059 0.231 1.0 -0.23 15.0 16.0 GRB2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.012 0.078 0.281 9.0 -0.251 14.0 23.0 cytoskeleton organization 0.01 0.042 0.196 5.0 -0.279 1.0 6.0 Nephrin/NEPH1 0.025 0.043 0.195 1.0 -0.205 14.0 15.0 Nephrin/NEPH1/ZO-1 0.04 0.053 0.226 1.0 -0.234 14.0 15.0