Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.019 0.215 -9999.0 0.0 -0.663 12.0 12.0 IHH 0.019 0.072 -9999.0 0.0 -0.794 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.124 0.199 -9999.0 0.0 -0.53 15.0 15.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.123 0.198 0.526 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 0.047 0.105 -9999.0 0.0 -0.708 1.0 1.0 SMO 0.041 0.111 -9999.0 0.0 -0.756 1.0 1.0 AKT1 0.051 0.055 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.041 0.11 -9999.0 0.0 -0.74 1.0 1.0 STIL -0.046 0.214 -9999.0 0.0 -0.611 9.0 9.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.024 0.082 -9999.0 0.0 -0.704 1.0 1.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.027 0.207 -9999.0 0.0 -1.563 1.0 1.0 determination of left/right symmetry 0.041 0.11 -9999.0 0.0 -0.74 1.0 1.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.028 0.203 -9999.0 0.0 -1.509 1.0 1.0 IHH N/Hhip -0.092 0.232 -9999.0 0.0 -0.522 34.0 34.0 DHH N/Hhip -0.104 0.194 -9999.0 0.0 -0.466 34.0 34.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.041 0.11 -9999.0 0.0 -0.74 1.0 1.0 pancreas development -0.129 0.273 -9999.0 0.0 -0.639 34.0 34.0 HHAT -0.052 0.201 -9999.0 0.0 -0.64 16.0 16.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.131 0.282 -9999.0 0.0 -0.668 33.0 33.0 somite specification 0.041 0.11 -9999.0 0.0 -0.74 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.006 0.152 -9999.0 0.0 -0.545 4.0 4.0 SHH Np/Cholesterol/PTCH2 -0.043 0.117 -9999.0 0.0 -0.432 2.0 2.0 SHH Np/Cholesterol/Megalin -0.043 0.117 -9999.0 0.0 -0.432 2.0 2.0 SHH -0.028 0.164 -9999.0 0.0 -0.476 18.0 18.0 catabolic process 0.036 0.114 -9999.0 0.0 -0.777 1.0 1.0 SMO/Vitamin D3 0.017 0.151 -9999.0 0.0 -0.562 3.0 3.0 SHH Np/Cholesterol/Hhip -0.122 0.206 -9999.0 0.0 -0.688 9.0 9.0 LRP2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.049 0.112 -9999.0 0.0 -0.611 1.0 1.0 SHH Np/Cholesterol/BOC -0.043 0.117 -9999.0 0.0 -0.432 2.0 2.0 SHH Np/Cholesterol/CDO -0.043 0.117 -9999.0 0.0 -0.432 2.0 2.0 mesenchymal cell differentiation 0.121 0.204 0.681 9.0 -9999.0 0.0 9.0 mol:Vitamin D3 0.01 0.154 -9999.0 0.0 -0.547 4.0 4.0 IHH N/PTCH2 0.027 0.046 -9999.0 0.0 -0.511 1.0 1.0 CDON 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.035 0.115 -9999.0 0.0 -0.791 1.0 1.0 Megalin/LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.044 0.121 -9999.0 0.0 -0.375 18.0 18.0 PTCH1 0.036 0.115 -9999.0 0.0 -0.781 1.0 1.0 HHIP -0.129 0.273 -9999.0 0.0 -0.64 34.0 34.0