Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.0 0.117 -9999.0 0.0 -0.748 1.0 1.0 epithelial cell differentiation -0.013 0.065 -9999.0 0.0 -0.395 1.0 1.0 CYFIP2 0.004 0.091 -9999.0 0.0 -0.64 3.0 3.0 ENAH 0.071 0.087 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.001 0.109 -9999.0 0.0 -0.665 4.0 4.0 EPHA2 -0.018 0.158 -9999.0 0.0 -0.74 7.0 7.0 MYO6 0.039 0.071 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.061 -9999.0 0.0 -0.74 1.0 1.0 ABI1/Sra1/Nap1 -0.011 0.066 -9999.0 0.0 -0.47 1.0 1.0 AQP5 -0.037 0.094 -9999.0 0.0 -0.59 1.0 1.0 CTNND1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.039 0.07 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.018 0.112 -9999.0 0.0 -0.623 1.0 1.0 EGF -0.207 0.327 -9999.0 0.0 -0.681 49.0 49.0 NCKAP1 0.012 0.061 -9999.0 0.0 -0.74 1.0 1.0 AQP3 -0.03 0.081 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization -0.013 0.065 -9999.0 0.0 -0.395 1.0 1.0 GO:0000145 0.038 0.067 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.013 0.066 -9999.0 0.0 -0.399 1.0 1.0 MLLT4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.024 0.091 -9999.0 0.0 -0.578 2.0 2.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.019 0.088 -9999.0 0.0 -0.422 7.0 7.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.053 0.071 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.036 0.078 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.018 0.08 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.005 0.117 -9999.0 0.0 -0.64 5.0 5.0 EGFR/EGFR/EGF/EGF -0.12 0.161 -9999.0 0.0 -0.644 2.0 2.0 RhoA/GDP -0.012 0.06 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.048 0.068 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.361 0.325 -9999.0 0.0 -0.64 88.0 88.0 DIAPH1 -0.014 0.096 -9999.0 0.0 -0.671 3.0 3.0 Wnt receptor signaling pathway 0.013 0.065 0.395 1.0 -9999.0 0.0 1.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.023 0.09 -9999.0 0.0 -0.578 2.0 2.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.048 0.07 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.047 0.073 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.028 0.108 -9999.0 0.0 -0.675 2.0 2.0 SEC6/SEC8 -0.01 0.05 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.018 0.114 -9999.0 0.0 -0.637 1.0 1.0 HGF/MET -0.183 0.183 -9999.0 0.0 -0.675 2.0 2.0 HGF 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.0 0.118 -9999.0 0.0 -0.758 1.0 1.0 actin cable formation 0.092 0.081 -9999.0 0.0 -0.414 1.0 1.0 KIAA1543 0.047 0.082 -9999.0 0.0 -0.606 1.0 1.0 KIFC3 0.036 0.078 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.039 0.071 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.013 0.065 -9999.0 0.0 -0.395 1.0 1.0 EXOC4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.039 0.071 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.039 0.071 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.048 0.195 -9999.0 0.0 -0.64 15.0 15.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.02 0.077 -9999.0 0.0 -0.487 2.0 2.0 adherens junction assembly 0.067 0.086 -9999.0 0.0 -0.627 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.175 0.156 -9999.0 0.0 -0.625 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.349 0.378 -9999.0 0.0 -0.74 74.0 74.0 PLEKHA7 0.039 0.071 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.019 0.087 -9999.0 0.0 -0.419 7.0 7.0 establishment of epithelial cell apical/basal polarity 0.075 0.064 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.0 0.117 -9999.0 0.0 -0.748 1.0 1.0 regulation of cell-cell adhesion 0.048 0.068 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.0 0.118 -9999.0 0.0 -0.758 1.0 1.0