Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.027 0.094 -9999.0 0.0 -0.726 1.0 1.0 IHH 0.032 0.062 -9999.0 0.0 -0.629 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.058 0.151 -9999.0 0.0 -0.321 31.0 31.0 LRPAP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.058 0.15 0.319 31.0 -9999.0 0.0 31.0 SMO/beta Arrestin2 0.04 0.079 -9999.0 0.0 -0.539 1.0 1.0 SMO 0.026 0.071 -9999.0 0.0 -0.565 1.0 1.0 AKT1 0.014 0.106 -9999.0 0.0 -0.37 2.0 2.0 ARRB2 0.027 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.026 0.07 -9999.0 0.0 -0.556 1.0 1.0 STIL -0.013 0.12 -9999.0 0.0 -0.365 7.0 7.0 DHH N/PTCH2 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.044 0.07 -9999.0 0.0 -0.5 1.0 1.0 PIK3CA 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.026 0.1 -9999.0 0.0 -0.888 1.0 1.0 determination of left/right symmetry 0.026 0.07 -9999.0 0.0 -0.556 1.0 1.0 PIK3R1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.026 0.099 -9999.0 0.0 -0.877 1.0 1.0 IHH N/Hhip -0.049 0.193 -9999.0 0.0 -0.417 31.0 31.0 DHH N/Hhip -0.042 0.171 -9999.0 0.0 -0.372 31.0 31.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.026 0.07 -9999.0 0.0 -0.556 1.0 1.0 pancreas development -0.083 0.222 -9999.0 0.0 -0.512 31.0 31.0 HHAT -0.02 0.16 -9999.0 0.0 -0.513 14.0 14.0 PI3K 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.075 0.207 -9999.0 0.0 -0.46 32.0 32.0 somite specification 0.026 0.07 -9999.0 0.0 -0.556 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.006 0.101 -9999.0 0.0 -0.379 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.0 0.095 -9999.0 0.0 -0.285 14.0 14.0 SHH Np/Cholesterol/Megalin 0.0 0.095 -9999.0 0.0 -0.286 14.0 14.0 SHH -0.019 0.118 0.229 1.0 -0.362 15.0 16.0 catabolic process 0.03 0.072 -9999.0 0.0 -0.552 1.0 1.0 SMO/Vitamin D3 0.008 0.101 -9999.0 0.0 -0.499 1.0 1.0 SHH Np/Cholesterol/Hhip -0.062 0.161 -9999.0 0.0 -0.324 37.0 37.0 LRP2 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.005 0.1 -9999.0 0.0 -0.461 1.0 1.0 SHH Np/Cholesterol/BOC 0.002 0.093 -9999.0 0.0 -0.286 13.0 13.0 SHH Np/Cholesterol/CDO -0.0 0.095 -9999.0 0.0 -0.286 14.0 14.0 mesenchymal cell differentiation 0.061 0.16 0.322 37.0 -9999.0 0.0 37.0 mol:Vitamin D3 0.013 0.108 -9999.0 0.0 -0.38 3.0 3.0 IHH N/PTCH2 0.047 0.039 -9999.0 0.0 -0.393 1.0 1.0 CDON 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.038 0.075 -9999.0 0.0 -0.559 1.0 1.0 Megalin/LRPAP1 0.046 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.091 -9999.0 0.0 -0.286 14.0 14.0 PTCH1 0.03 0.072 -9999.0 0.0 -0.554 1.0 1.0 HHIP -0.083 0.222 -9999.0 0.0 -0.513 31.0 31.0