Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.004 0.102 -9999.0 0.0 -0.254 19.0 19.0 epithelial cell differentiation 0.054 0.065 -9999.0 0.0 -0.268 5.0 5.0 CYFIP2 0.021 0.077 -9999.0 0.0 -0.513 3.0 3.0 ENAH -0.003 0.053 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.019 0.077 -9999.0 0.0 -0.513 3.0 3.0 EPHA2 0.013 0.076 -9999.0 0.0 -0.325 7.0 7.0 MYO6 0.01 0.052 -9999.0 0.0 -0.258 5.0 5.0 CTNNB1 0.03 0.03 -9999.0 0.0 -0.325 1.0 1.0 ABI1/Sra1/Nap1 0.055 0.058 -9999.0 0.0 -0.316 3.0 3.0 AQP5 0.006 0.054 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.01 0.052 -9999.0 0.0 -0.254 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.002 0.079 -9999.0 0.0 -0.28 10.0 10.0 EGF -0.111 0.224 -9999.0 0.0 -0.446 44.0 44.0 NCKAP1 0.03 0.029 -9999.0 0.0 -0.325 1.0 1.0 AQP3 0.008 0.055 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization 0.054 0.065 -9999.0 0.0 -0.268 5.0 5.0 GO:0000145 -0.004 0.047 -9999.0 0.0 -0.243 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.06 0.067 -9999.0 0.0 -0.27 5.0 5.0 MLLT4 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.009 0.059 -9999.0 0.0 -0.352 2.0 2.0 ARF6 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.058 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.005 0.046 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.009 0.054 -9999.0 0.0 -0.258 5.0 5.0 ARF6/GTP 0.063 0.061 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.014 0.099 -9999.0 0.0 -0.513 5.0 5.0 EGFR/EGFR/EGF/EGF -0.037 0.135 -9999.0 0.0 -0.49 1.0 1.0 RhoA/GDP 0.056 0.063 -9999.0 0.0 -0.255 5.0 5.0 actin cytoskeleton organization 0.003 0.05 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.29 0.268 -9999.0 0.0 -0.513 87.0 87.0 DIAPH1 0.045 0.13 -9999.0 0.0 -0.655 3.0 3.0 Wnt receptor signaling pathway -0.054 0.065 0.268 5.0 -9999.0 0.0 5.0 RHOA 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.009 0.059 -9999.0 0.0 -0.353 2.0 2.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.003 0.051 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.001 0.048 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.035 0.079 -9999.0 0.0 -0.386 2.0 2.0 SEC6/SEC8 0.007 0.048 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.002 0.08 -9999.0 0.0 -0.284 10.0 10.0 HGF/MET -0.046 0.109 -9999.0 0.0 -0.386 2.0 2.0 HGF 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.004 0.103 -9999.0 0.0 -0.256 19.0 19.0 actin cable formation 0.014 0.072 0.264 3.0 -0.308 1.0 4.0 KIAA1543 -0.004 0.047 -9999.0 0.0 -0.246 5.0 5.0 KIFC3 0.01 0.054 -9999.0 0.0 -0.258 5.0 5.0 NCK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.009 0.052 -9999.0 0.0 -0.258 5.0 5.0 NCK1/GIT1 0.045 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.054 0.065 -9999.0 0.0 -0.268 5.0 5.0 EXOC4 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.01 0.052 -9999.0 0.0 -0.258 5.0 5.0 PIP5K1C 0.01 0.052 -9999.0 0.0 -0.258 5.0 5.0 LIMA1 -0.023 0.165 -9999.0 0.0 -0.513 15.0 15.0 ABI1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.004 0.067 0.308 1.0 -0.314 2.0 3.0 adherens junction assembly 0.008 0.049 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.133 0.16 -9999.0 0.0 -0.465 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.132 0.177 -9999.0 0.0 -0.326 67.0 67.0 PLEKHA7 0.01 0.052 -9999.0 0.0 -0.258 5.0 5.0 mol:GTP 0.058 0.057 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.023 0.071 0.336 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.004 0.102 -9999.0 0.0 -0.254 19.0 19.0 regulation of cell-cell adhesion 0.003 0.05 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.004 0.103 -9999.0 0.0 -0.256 19.0 19.0