Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.043 0.142 -9999.0 0.0 -0.3 9.0 9.0 epithelial cell differentiation -0.047 0.132 -9999.0 0.0 -0.297 9.0 9.0 CYFIP2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.002 0.11 -9999.0 0.0 -0.407 1.0 1.0 EGFR -0.061 0.172 -9999.0 0.0 -0.438 8.0 8.0 EPHA2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.06 0.14 -9999.0 0.0 -0.296 10.0 10.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.013 0.077 -9999.0 0.0 -0.357 2.0 2.0 AQP5 -0.061 0.097 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.037 0.125 -9999.0 0.0 -0.274 9.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.056 0.149 -9999.0 0.0 -0.301 11.0 11.0 EGF -0.019 0.096 -9999.0 0.0 -0.388 3.0 3.0 NCKAP1 -0.011 0.121 -9999.0 0.0 -0.59 2.0 2.0 AQP3 -0.07 0.119 -9999.0 0.0 -0.393 3.0 3.0 cortical microtubule organization -0.047 0.132 -9999.0 0.0 -0.297 9.0 9.0 GO:0000145 -0.036 0.119 -9999.0 0.0 -0.262 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.045 0.134 -9999.0 0.0 -0.3 9.0 9.0 MLLT4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.051 0.087 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.027 0.13 -9999.0 0.0 -0.44 1.0 1.0 PVRL2 0.006 0.057 -9999.0 0.0 -0.388 1.0 1.0 ZYX -0.038 0.127 -9999.0 0.0 -0.278 9.0 9.0 ARF6/GTP 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.132 0.246 -9999.0 0.0 -0.528 13.0 13.0 EGFR/EGFR/EGF/EGF -0.101 0.132 -9999.0 0.0 -0.312 10.0 10.0 RhoA/GDP -0.064 0.109 -9999.0 0.0 -0.275 9.0 9.0 actin cytoskeleton organization -0.054 0.134 -9999.0 0.0 -0.279 10.0 10.0 IGF-1R heterotetramer 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.028 0.142 -9999.0 0.0 -0.489 4.0 4.0 DIAPH1 -0.022 0.128 -9999.0 0.0 -0.632 2.0 2.0 Wnt receptor signaling pathway 0.047 0.132 0.297 9.0 -9999.0 0.0 9.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.088 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.056 0.137 -9999.0 0.0 -0.286 10.0 10.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.035 0.139 -9999.0 0.0 -0.554 1.0 1.0 Ephrin A1/EPHA2 -0.061 0.104 -9999.0 0.0 -0.263 9.0 9.0 SEC6/SEC8 -0.057 0.094 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.057 0.151 -9999.0 0.0 -0.306 11.0 11.0 HGF/MET -0.134 0.178 -9999.0 0.0 -0.352 15.0 15.0 HGF -0.04 0.163 -9999.0 0.0 -0.509 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.044 0.143 -9999.0 0.0 -0.302 9.0 9.0 actin cable formation 0.013 0.112 -9999.0 0.0 -0.409 1.0 1.0 KIAA1543 -0.098 0.185 -9999.0 0.0 -0.35 14.0 14.0 KIFC3 -0.044 0.131 -9999.0 0.0 -0.278 10.0 10.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.038 0.127 -9999.0 0.0 -0.278 9.0 9.0 NCK1/GIT1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.047 0.132 -9999.0 0.0 -0.297 9.0 9.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.038 0.127 -9999.0 0.0 -0.278 9.0 9.0 PIP5K1C -0.038 0.127 -9999.0 0.0 -0.278 9.0 9.0 LIMA1 -0.007 0.103 -9999.0 0.0 -0.489 2.0 2.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.0 0.103 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.083 0.192 -9999.0 0.0 -0.486 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.079 0.133 -9999.0 0.0 -0.498 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.015 0.04 -9999.0 0.0 -0.261 1.0 1.0 MET -0.103 0.209 -9999.0 0.0 -0.455 12.0 12.0 PLEKHA7 -0.069 0.146 -9999.0 0.0 -0.294 12.0 12.0 mol:GTP 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.011 0.114 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.043 0.142 -9999.0 0.0 -0.3 9.0 9.0 regulation of cell-cell adhesion -0.054 0.134 -9999.0 0.0 -0.279 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.044 0.143 -9999.0 0.0 -0.302 9.0 9.0