Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.011 0.098 -9999.0 0.0 -0.265 5.0 5.0 epithelial cell differentiation 0.016 0.097 -9999.0 0.0 -0.21 7.0 7.0 CYFIP2 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.019 0.076 0.422 1.0 -9999.0 0.0 1.0 EGFR 0.0 0.09 -9999.0 0.0 -0.408 2.0 2.0 EPHA2 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.024 0.096 0.245 3.0 -0.192 7.0 10.0 CTNNB1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.063 -9999.0 0.0 -0.247 2.0 2.0 AQP5 -0.01 0.053 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.027 0.097 0.238 3.0 -0.201 7.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.042 0.107 0.263 2.0 -0.221 9.0 11.0 EGF -0.002 0.027 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.012 0.088 -9999.0 0.0 -0.408 2.0 2.0 AQP3 -0.016 0.088 -9999.0 0.0 -0.442 1.0 1.0 cortical microtubule organization 0.016 0.097 -9999.0 0.0 -0.21 7.0 7.0 GO:0000145 -0.026 0.093 0.227 3.0 -0.192 7.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.021 0.1 -9999.0 0.0 -0.211 7.0 7.0 MLLT4 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.045 0.061 -9999.0 0.0 -0.19 7.0 7.0 ARF6 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.067 0.028 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.019 0.065 0.187 1.0 -0.201 1.0 2.0 PVRL2 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.026 0.09 0.271 2.0 -0.203 6.0 8.0 ARF6/GTP 0.073 0.03 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.045 0.153 -9999.0 0.0 -0.408 7.0 7.0 EGFR/EGFR/EGF/EGF 0.005 0.103 -9999.0 0.0 -0.23 7.0 7.0 RhoA/GDP 0.017 0.093 -9999.0 0.0 -0.199 7.0 7.0 actin cytoskeleton organization -0.022 0.087 0.22 3.0 -0.188 6.0 9.0 IGF-1R heterotetramer 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.009 0.088 -9999.0 0.0 -0.408 2.0 2.0 DIAPH1 0.018 0.148 -9999.0 0.0 -0.572 1.0 1.0 Wnt receptor signaling pathway -0.016 0.097 0.21 7.0 -9999.0 0.0 7.0 RHOA 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.045 0.061 -9999.0 0.0 -0.192 6.0 6.0 CTNNA1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.022 0.089 0.222 3.0 -0.191 6.0 9.0 EFNA1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.034 0.068 0.185 1.0 -0.197 5.0 6.0 Ephrin A1/EPHA2 0.01 0.09 -9999.0 0.0 -0.2 7.0 7.0 SEC6/SEC8 -0.034 0.046 -9999.0 0.0 -0.181 4.0 4.0 MGAT3 -0.043 0.109 0.265 2.0 -0.224 9.0 11.0 HGF/MET 0.004 0.097 -9999.0 0.0 -0.203 8.0 8.0 HGF 0.006 0.089 -9999.0 0.0 -0.408 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.011 0.099 -9999.0 0.0 -0.267 5.0 5.0 actin cable formation 0.013 0.113 0.486 2.0 -9999.0 0.0 2.0 KIAA1543 -0.038 0.103 0.229 3.0 -0.197 10.0 13.0 KIFC3 -0.042 0.078 0.176 1.0 -0.204 8.0 9.0 NCK1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.027 0.098 0.24 3.0 -0.203 7.0 10.0 NCK1/GIT1 0.042 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.016 0.097 -9999.0 0.0 -0.21 7.0 7.0 EXOC4 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.034 0.081 0.182 2.0 -0.203 7.0 9.0 PIP5K1C -0.027 0.098 0.24 3.0 -0.203 7.0 10.0 LIMA1 0.016 0.064 -9999.0 0.0 -0.408 1.0 1.0 ABI1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.001 0.116 0.392 3.0 -9999.0 0.0 3.0 adherens junction assembly -0.048 0.154 0.459 1.0 -0.574 2.0 3.0 IGF-1R heterotetramer/IGF1 0.008 0.103 -9999.0 0.0 -0.226 7.0 7.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.011 0.107 -9999.0 0.0 -0.408 3.0 3.0 PLEKHA7 -0.039 0.108 0.24 3.0 -0.206 10.0 13.0 mol:GTP 0.064 0.027 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.017 0.081 0.313 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.011 0.098 -9999.0 0.0 -0.265 5.0 5.0 regulation of cell-cell adhesion -0.022 0.087 0.22 3.0 -0.188 6.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.011 0.099 -9999.0 0.0 -0.267 5.0 5.0