Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	11.0	405.0	34.0	-0.116	0.03	1000.0	-1000.0	-0.024	-1000.0
IL4-mediated signaling events	9.0	904.0	91.0	-0.749	0.685	1000.0	-1000.0	-0.079	-1000.0
IL23-mediated signaling events	7.0	436.0	60.0	-0.425	0.03	1000.0	-1000.0	-0.077	-1000.0
Syndecan-1-mediated signaling events	6.0	218.0	34.0	-0.094	0.03	1000.0	-1000.0	-0.021	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	560.0	93.0	-0.189	0.042	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.028	-1000.0	1000.0	-1000.0	-0.011	-1000.0
Osteopontin-mediated events	5.0	198.0	38.0	-0.132	0.03	1000.0	-1000.0	-0.015	-1000.0
Glucocorticoid receptor regulatory network	5.0	668.0	114.0	-0.433	0.268	1000.0	-1000.0	-0.043	-1000.0
Endothelins	5.0	573.0	96.0	-0.134	0.032	1000.0	-1000.0	-0.033	-1000.0
IL12-mediated signaling events	4.0	427.0	87.0	-0.255	0.077	1000.0	-1000.0	-0.043	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	348.0	82.0	-0.125	0.03	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	218.0	44.0	-0.084	0.03	1000.0	-1000.0	-0.018	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	142.0	31.0	-0.158	0.03	1000.0	-1000.0	-0.034	-1000.0
LPA receptor mediated events	4.0	447.0	102.0	-0.12	0.03	1000.0	-1000.0	-0.06	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	301.0	68.0	-0.253	0.054	1000.0	-1000.0	-0.06	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	300.0	74.0	-0.048	0.073	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling events	4.0	24.0	5.0	-0.045	0.029	1000.0	-1000.0	0.011	-1000.0
ErbB2/ErbB3 signaling events	3.0	212.0	65.0	-0.116	0.042	1000.0	-1000.0	-0.039	-1000.0
Caspase cascade in apoptosis	3.0	253.0	74.0	-0.095	0.063	1000.0	-1000.0	-0.032	-1000.0
BARD1 signaling events	3.0	199.0	57.0	-0.066	0.054	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by the Hedgehog family	3.0	192.0	52.0	-0.103	0.041	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	64.0	17.0	-0.141	0.037	1000.0	-1000.0	-0.028	-1000.0
Noncanonical Wnt signaling pathway	3.0	93.0	26.0	-0.055	0.03	1000.0	-1000.0	-0.031	-1000.0
Thromboxane A2 receptor signaling	3.0	407.0	105.0	-0.065	0.031	1000.0	-1000.0	-0.025	-1000.0
HIF-1-alpha transcription factor network	3.0	280.0	76.0	-0.185	0.037	1000.0	-1000.0	-0.037	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	257.0	85.0	-0.081	0.044	1000.0	-1000.0	-0.045	-1000.0
Arf6 downstream pathway	3.0	152.0	43.0	-0.081	0.04	1000.0	-1000.0	-0.025	-1000.0
amb2 Integrin signaling	3.0	262.0	82.0	-0.105	0.054	1000.0	-1000.0	-0.027	-1000.0
Ephrin B reverse signaling	3.0	156.0	48.0	-0.067	0.031	1000.0	-1000.0	-0.027	-1000.0
FAS signaling pathway (CD95)	3.0	178.0	47.0	-0.137	0.043	1000.0	-1000.0	-0.025	-1000.0
EPHB forward signaling	3.0	260.0	85.0	-0.125	0.055	1000.0	-1000.0	-0.046	-1000.0
Wnt signaling	3.0	23.0	7.0	-0.033	0.027	1000.0	-1000.0	-0.01	-1000.0
IL6-mediated signaling events	3.0	292.0	75.0	-0.167	0.043	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	258.0	76.0	-0.058	0.048	1000.0	-1000.0	-0.037	-1000.0
BCR signaling pathway	3.0	336.0	99.0	-0.07	0.073	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in keratinocytes	3.0	155.0	43.0	-0.058	0.031	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	310.0	78.0	-0.097	0.044	1000.0	-1000.0	-0.032	-1000.0
Coregulation of Androgen receptor activity	2.0	156.0	76.0	-0.258	0.081	1000.0	-1000.0	-0.015	-1000.0
Syndecan-2-mediated signaling events	2.0	151.0	69.0	-0.084	0.059	1000.0	-1000.0	-0.031	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	11.0	5.0	0.001	0.022	1000.0	-1000.0	0.009	-1000.0
Arf6 signaling events	2.0	149.0	62.0	-0.038	0.067	1000.0	-1000.0	-0.014	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	142.0	61.0	-0.079	0.076	1000.0	-1000.0	-0.037	-1000.0
p75(NTR)-mediated signaling	2.0	339.0	125.0	-0.051	0.075	1000.0	-1000.0	-0.055	-1000.0
BMP receptor signaling	2.0	172.0	81.0	-0.061	0.054	1000.0	-1000.0	-0.027	-1000.0
Glypican 1 network	2.0	101.0	48.0	-0.11	0.056	1000.0	-1000.0	-0.015	-1000.0
Nectin adhesion pathway	2.0	168.0	63.0	-0.055	0.052	1000.0	-1000.0	-0.024	-1000.0
Ceramide signaling pathway	2.0	175.0	76.0	-0.062	0.061	1000.0	-1000.0	-0.032	-1000.0
Reelin signaling pathway	2.0	133.0	56.0	-0.035	0.043	1000.0	-1000.0	-0.019	-1000.0
IL1-mediated signaling events	2.0	129.0	62.0	-0.052	0.061	1000.0	-1000.0	-0.023	-1000.0
S1P5 pathway	2.0	47.0	17.0	-0.047	0.03	1000.0	-1000.0	-0.005	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	30.0	15.0	-0.031	0.03	1000.0	-1000.0	-0.027	-1000.0
Integrins in angiogenesis	2.0	235.0	84.0	-0.081	0.05	1000.0	-1000.0	-0.032	-1000.0
Canonical Wnt signaling pathway	2.0	126.0	51.0	-0.119	0.036	1000.0	-1000.0	-0.04	-1000.0
IL27-mediated signaling events	2.0	140.0	51.0	-0.135	0.07	1000.0	-1000.0	-0.038	-1000.0
TCGA08_retinoblastoma	2.0	21.0	8.0	-0.004	0.036	1000.0	-1000.0	-0.002	-1000.0
Syndecan-4-mediated signaling events	2.0	172.0	67.0	-0.1	0.039	1000.0	-1000.0	-0.028	-1000.0
Plasma membrane estrogen receptor signaling	2.0	252.0	86.0	-0.12	0.07	1000.0	-1000.0	-0.034	-1000.0
S1P3 pathway	2.0	93.0	42.0	-0.047	0.042	1000.0	-1000.0	-0.016	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	268.0	120.0	-0.077	0.077	1000.0	-1000.0	-0.033	-1000.0
Visual signal transduction: Rods	2.0	111.0	52.0	-0.051	0.033	1000.0	-1000.0	-0.014	-1000.0
S1P4 pathway	2.0	71.0	25.0	-0.047	0.036	1000.0	-1000.0	-0.015	-1000.0
Regulation of Androgen receptor activity	2.0	176.0	70.0	-0.262	0.034	1000.0	-1000.0	-0.037	-1000.0
LPA4-mediated signaling events	1.0	20.0	12.0	-0.04	0.01	1000.0	-1000.0	-0.02	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	163.0	136.0	-0.115	0.113	1000.0	-1000.0	-0.037	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	23.0	23.0	-0.071	0.05	1000.0	-1000.0	-0.016	-1000.0
ErbB4 signaling events	1.0	69.0	69.0	-0.038	0.041	1000.0	-1000.0	-0.025	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	41.0	28.0	-0.047	0.036	1000.0	-1000.0	-0.011	-1000.0
Visual signal transduction: Cones	1.0	40.0	38.0	-0.033	0.051	1000.0	-1000.0	-0.007	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	88.0	54.0	-0.033	0.043	1000.0	-1000.0	-0.022	-1000.0
Ephrin A  reverse signaling	1.0	7.0	7.0	-0.015	0.028	1000.0	-1000.0	-0.006	-1000.0
Cellular roles of Anthrax toxin	1.0	75.0	39.0	-0.035	0.03	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by PTP1B	1.0	111.0	76.0	-0.101	0.042	1000.0	-1000.0	-0.023	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	100.0	65.0	-0.097	0.064	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	1.0	8.0	7.0	-0.0	0.026	1000.0	-1000.0	-0.003	-1000.0
FOXA2 and FOXA3 transcription factor networks	1.0	51.0	46.0	-0.121	0.034	1000.0	-1000.0	-0.062	-1000.0
EPO signaling pathway	1.0	87.0	55.0	-0.027	0.065	1000.0	-1000.0	-0.023	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	176.0	97.0	-0.082	0.058	1000.0	-1000.0	-0.045	-1000.0
PLK1 signaling events	1.0	114.0	85.0	-0.044	0.046	1000.0	-1000.0	-0.029	-1000.0
PDGFR-alpha signaling pathway	1.0	56.0	44.0	-0.072	0.061	1000.0	-1000.0	-0.034	-1000.0
mTOR signaling pathway	1.0	103.0	53.0	-0.077	0.048	1000.0	-1000.0	-0.024	-1000.0
IFN-gamma pathway	1.0	118.0	68.0	-0.043	0.046	1000.0	-1000.0	-0.037	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	69.0	37.0	-0.069	0.053	1000.0	-1000.0	-0.019	-1000.0
ceramide signaling pathway	1.0	57.0	49.0	-0.011	0.05	1000.0	-1000.0	-0.028	-1000.0
HIF-2-alpha transcription factor network	1.0	50.0	43.0	-0.069	0.071	1000.0	-1000.0	-0.034	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	100.0	83.0	-0.054	0.054	1000.0	-1000.0	-0.021	-1000.0
S1P1 pathway	1.0	69.0	36.0	-0.09	0.029	1000.0	-1000.0	-0.02	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.008	0.028	1000.0	-1000.0	-0.004	-1000.0
Retinoic acid receptors-mediated signaling	1.0	85.0	58.0	-0.043	0.06	1000.0	-1000.0	-0.031	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	43.0	36.0	-0.041	0.047	1000.0	-1000.0	-0.022	-1000.0
Syndecan-3-mediated signaling events	1.0	39.0	35.0	-0.069	0.075	1000.0	-1000.0	-0.019	-1000.0
IL2 signaling events mediated by PI3K	1.0	81.0	58.0	-0.044	0.043	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	68.0	45.0	-0.059	0.065	1000.0	-1000.0	-0.029	-1000.0
Regulation of p38-alpha and p38-beta	1.0	87.0	54.0	-0.072	0.063	1000.0	-1000.0	-0.039	-1000.0
Effects of Botulinum toxin	1.0	49.0	26.0	-0.054	0.044	1000.0	-1000.0	-0.002	-1000.0
Nongenotropic Androgen signaling	1.0	77.0	52.0	-0.054	0.045	1000.0	-1000.0	-0.023	-1000.0
Class I PI3K signaling events	1.0	100.0	73.0	-0.065	0.053	1000.0	-1000.0	-0.026	-1000.0
EGFR-dependent Endothelin signaling events	1.0	23.0	21.0	-0.025	0.06	1000.0	-1000.0	-0.031	-1000.0
IGF1 pathway	1.0	107.0	57.0	-0.016	0.067	1000.0	-1000.0	-0.032	-1000.0
Insulin Pathway	1.0	116.0	74.0	-0.135	0.067	1000.0	-1000.0	-0.035	-1000.0
VEGFR1 specific signals	1.0	59.0	56.0	-0.029	0.05	1000.0	-1000.0	-0.034	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	138.0	88.0	-0.125	0.039	1000.0	-1000.0	-0.059	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	47.0	33.0	-0.012	0.077	1000.0	-1000.0	-0.022	-1000.0
Rapid glucocorticoid signaling	1.0	21.0	20.0	-0.035	0.027	1000.0	-1000.0	-0.001	-1000.0
PDGFR-beta signaling pathway	1.0	182.0	97.0	-0.125	0.065	1000.0	-1000.0	-0.042	-1000.0
FOXM1 transcription factor network	1.0	59.0	51.0	-0.072	0.058	1000.0	-1000.0	-0.063	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	31.0	17.0	-0.015	0.05	1000.0	-1000.0	-0.015	-1000.0
Aurora B signaling	1.0	75.0	67.0	-0.166	0.066	1000.0	-1000.0	-0.029	-1000.0
Canonical NF-kappaB pathway	0.0	23.0	39.0	-0.0	0.064	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class II	0.0	50.0	75.0	-0.054	0.066	1000.0	-1000.0	-0.026	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.006	-1000.0	1000.0	-1000.0	-0.01	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.009	0.063	1000.0	-1000.0	-0.034	-1000.0
Aurora A signaling	0.0	10.0	60.0	-0.002	0.06	1000.0	-1000.0	-0.015	-1000.0
Insulin-mediated glucose transport	0.0	18.0	32.0	-0.035	0.054	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	62.0	68.0	-0.035	0.056	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class III	0.0	13.0	40.0	-0.05	0.051	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	0.0	30.0	48.0	-0.005	0.063	1000.0	-1000.0	-0.019	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	0.0	27.0	52.0	-0.011	0.085	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class I	0.0	43.0	104.0	-0.053	0.064	1000.0	-1000.0	-0.033	-1000.0
FoxO family signaling	0.0	60.0	64.0	-0.111	0.052	1000.0	-1000.0	-0.046	-1000.0
Atypical NF-kappaB pathway	0.0	17.0	31.0	-0.0	0.041	1000.0	-1000.0	-0.008	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.021	0.041	1000.0	-1000.0	0.007	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	98.0	125.0	-0.028	0.068	1000.0	-1000.0	-0.028	-1000.0
TCGA08_rtk_signaling	0.0	14.0	26.0	-0.02	0.057	1000.0	-1000.0	-0.008	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	5.0	27.0	-0.0	0.06	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by STAT5	0.0	21.0	22.0	-0.025	0.031	1000.0	-1000.0	-0.024	-1000.0
Arf6 trafficking events	0.0	16.0	71.0	-0.046	0.055	1000.0	-1000.0	-0.03	-1000.0
Regulation of Telomerase	0.0	71.0	102.0	-0.035	0.069	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by PRL	0.0	31.0	34.0	-0.04	0.044	1000.0	-1000.0	-0.037	-1000.0
p38 MAPK signaling pathway	0.0	30.0	44.0	-0.024	0.049	1000.0	-1000.0	-0.016	-1000.0
Arf1 pathway	0.0	11.0	54.0	-0.004	0.054	1000.0	-1000.0	-0.014	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.079	1000.0	-1000.0	-0.0	-1000.0
Total	247	18039	7203	-10.5036644364	-1992.71038059	131000	-131000	-3.51753809222	-131000